                         SEQUENCE LISTING

<110>  MacroGenics Inc.
       Moore, Paul A
       Johnson, Leslie S
       Li, Jonathan C.
       Shah, Kalpana
 
<120>  Multivalent Molecules Comprising DR5-Binding Domains

<130>  1301.0118PCT

<150>  62/149,139
<151>  2015-04-17

<150>  62/107,871
<151>  2015-01-26

<160>  168   

<170>  PatentIn version 3.5

<210>  1
<211>  217
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(218)
<223>  Human Wild-Type IgG CH2-CH3 Domain

<400>  1

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  2
<211>  440
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(440)
<223>  human Death Receptor 5 precursor protein

<220>
<221>  mat_peptide
<222>  (1)..(440)

<220>
<221>  SIGNAL
<222>  (1)..(55)

<400>  2

Met Glu Gln Arg Gly Gln Asn Ala Pro Ala Ala Ser Gly Ala Arg Lys 
1               5                   10                  15      


Arg His Gly Pro Gly Pro Arg Glu Ala Arg Gly Ala Arg Pro Gly Leu 
            20                  25                  30          


Arg Val Pro Lys Thr Leu Val Leu Val Val Ala Ala Val Leu Leu Leu 
        35                  40                  45              


Val Ser Ala Glu Ser Ala Leu Ile Thr Gln Gln Asp Leu Ala Pro Gln 
    50                  55                  60                  


Gln Arg Val Ala Pro Gln Gln Lys Arg Ser Ser Pro Ser Glu Gly Leu 
65                  70                  75                  80  


Cys Pro Pro Gly His His Ile Ser Glu Asp Gly Arg Asp Cys Ile Ser 
                85                  90                  95      


Cys Lys Tyr Gly Gln Asp Tyr Ser Thr His Trp Asn Asp Leu Leu Phe 
            100                 105                 110         


Cys Leu Arg Cys Thr Arg Cys Asp Ser Gly Glu Val Glu Leu Ser Pro 
        115                 120                 125             


Cys Thr Thr Thr Arg Asn Thr Val Cys Gln Cys Glu Glu Gly Thr Phe 
    130                 135                 140                 


Arg Glu Glu Asp Ser Pro Glu Met Cys Arg Lys Cys Arg Thr Gly Cys 
145                 150                 155                 160 


Pro Arg Gly Met Val Lys Val Gly Asp Cys Thr Pro Trp Ser Asp Ile 
                165                 170                 175     


Glu Cys Val His Lys Glu Ser Gly Thr Lys His Ser Gly Glu Ala Pro 
            180                 185                 190         


Ala Val Glu Glu Thr Val Thr Ser Ser Pro Gly Thr Pro Ala Ser Pro 
        195                 200                 205             


Cys Ser Leu Ser Gly Ile Ile Ile Gly Val Thr Val Ala Ala Val Val 
    210                 215                 220                 


Leu Ile Val Ala Val Phe Val Cys Lys Ser Leu Leu Trp Lys Lys Val 
225                 230                 235                 240 


Leu Pro Tyr Leu Lys Gly Ile Cys Ser Gly Gly Gly Gly Asp Pro Glu 
                245                 250                 255     


Arg Val Asp Arg Ser Ser Gln Arg Pro Gly Ala Glu Asp Asn Val Leu 
            260                 265                 270         


Asn Glu Ile Val Ser Ile Leu Gln Pro Thr Gln Val Pro Glu Gln Glu 
        275                 280                 285             


Met Glu Val Gln Glu Pro Ala Glu Pro Thr Gly Val Asn Met Leu Ser 
    290                 295                 300                 


Pro Gly Glu Ser Glu His Leu Leu Glu Pro Ala Glu Ala Glu Arg Ser 
305                 310                 315                 320 


Gln Arg Arg Arg Leu Leu Val Pro Ala Asn Glu Gly Asp Pro Thr Glu 
                325                 330                 335     


Thr Leu Arg Gln Cys Phe Asp Asp Phe Ala Asp Leu Val Pro Phe Asp 
            340                 345                 350         


Ser Trp Glu Pro Leu Met Arg Lys Leu Gly Leu Met Asp Asn Glu Ile 
        355                 360                 365             


Lys Val Ala Lys Ala Glu Ala Ala Gly His Arg Asp Thr Leu Tyr Thr 
    370                 375                 380                 


Met Leu Ile Lys Trp Val Asn Lys Thr Gly Arg Asp Ala Ser Val His 
385                 390                 395                 400 


Thr Leu Leu Asp Ala Leu Glu Thr Leu Gly Glu Arg Leu Ala Lys Gln 
                405                 410                 415     


Lys Ile Glu Asp His Leu Leu Ser Ser Gly Lys Phe Met Tyr Leu Glu 
            420                 425                 430         


Gly Asn Ala Asp Ser Ala Met Ser 
        435                 440 


<210>  3
<211>  111
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(111)
<223>  Anti-DR5 Antibody mAb 1 Light Chain Variable Region

<400>  3

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Ser Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Val Leu Ile Phe Leu Ser Ser Asn Leu Asp Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Asp Gly Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  4
<211>  15
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  Anti-DR5 Antibody mAb 1 Light Chain Variable Region CDRL1

<400>  4

Arg Ala Ser Lys Ser Val Ser Ser Ser Gly Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  5
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  Anti-DR5 Antibody mAb 1 Light Chain Variable Region CDRL2

<400>  5

Leu Ser Ser Asn Leu Asp Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  Anti-DR5 Antibody mAb 1 Light Chain Variable Region CDRL3

<400>  6

Gln His Ser Arg Asp Leu Pro Pro Thr 
1               5                   


<210>  7
<211>  333
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(333)
<223>  Polynucleotide Encoding Anti-DR5 Antibody mAb 1 Light Chain 
       Variable Region

<400>  7
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctcgggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt tcctctggct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaagtc ctcatctttc tttcatccaa cctagattct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg atggggatgc tgcaacctat tactgtcagc acagtaggga tcttcctccg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  8
<211>  121
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(121)
<223>  Anti-DR5 Antibody mAb 1 Heavy Chain Variable Region

<400>  8

Glu Val Lys Phe Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asp Ser Asn Thr Ile Asn Tyr Thr Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Arg Ala Tyr Tyr Gly Asn Pro Ala Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  9
<211>  10
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  Anti-DR5 Antibody mAb 1 Light Chain Variable Region CDRH1

<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  Anti-DR5 Antibody mAb 1 Heavy Chain Variable Region CDRH1

<400>  9

Gly Phe Asp Phe Ser Arg Tyr Trp Met Ser 
1               5                   10  


<210>  10
<211>  17
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  Anti-DR5 Antibody mAb 1 Heavy Chain Variable Region CDRH2

<400>  10

Glu Ile Asn Pro Asp Ser Asn Thr Ile Asn Tyr Thr Pro Ser Leu Lys 
1               5                   10                  15      


Asp 
    


<210>  11
<211>  12
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  Anti-DR5 Antibody mAb 1 Heavy Chain Variable Region CDRH3

<400>  11

Arg Ala Tyr Tyr Gly Asn Pro Ala Trp Phe Ala Tyr 
1               5                   10          


<210>  12
<211>  363
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Polynucleotide Encoding Anti-DR5 Antibody mAb 1 Heavy Chain 
       Variable Region

<400>  12
gaggtgaagt ttctcgagtc tggaggtggc ctggtgcagc ctggaggatc cctgaaactc       60

tcctgtgtag cctcaggatt cgattttagt agatactgga tgagttgggt ccggcaggct      120

ccagggaaag ggctagaatg gattggagaa attaatccag atagcaatac gataaactat      180

acgccatctc taaaggataa attcatcatc tccagagaca acgccaaaaa tacgctgtat      240

ctgcaaatga ccaaagtgag atctgaggac acagcccttt attattgtac aagaagggcc      300

tactatggta acccggcctg gtttgcttac tggggccaag ggactctggt cactgtctct      360

tcc                                                                    363


<210>  13
<211>  107
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Anti-DR5 Antibody mAb 2 Light Chain Variable Region

<400>  13

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Lys Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Thr Leu Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  14
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  Anti-DR5 Antibody mAb 2 Light Chain Variable Region CDRL1

<400>  14

Lys Ala Ser Gln Asp Val Asn Thr Ala Val Ala 
1               5                   10      


<210>  15
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  Anti-DR5 Antibody mAb 2 Light Chain Variable Region CDRL2

<400>  15

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  16
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  Anti-DR5 Antibody mAb 2 Light Chain Variable Region CDRL3

<400>  16

Gln Gln His Tyr Ile Thr Pro Trp Thr 
1               5                   


<210>  17
<211>  321
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Polynucleotide Encoding Anti-DR5 Antibody mAb 2 Light Chain 
       Variable Region

<400>  17
gacattgtga tgacccagtc tcacaaattc atgtccactt cagtaggaga cagggtcagc       60

atcacctgca aggccagtca ggatgtgaat actgctgtag cctggtatca acaaaaacca      120

gggcaatctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat tatacactca ccatcaaaag tgtgcaggct      240

gaagacctga cactttatta ctgtcagcaa cactatatca ctccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  18
<211>  119
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(119)
<223>  Anti-DR5 Antibody mAb 2 Heavy Chain Variable Region

<400>  18

Lys Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ile Leu His Trp Val Lys Gln Lys Ser Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe Tyr Pro Gly Asn Asn Asn Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Glu Gln Gly Pro Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  19
<211>  10
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  Anti-DR5 Antibody mAb 2 Heavy Chain Variable Region CDRH1

<400>  19

Gly Tyr Thr Phe Thr Glu Tyr Ile Leu His 
1               5                   10  


<210>  20
<211>  17
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  Anti-DR5 Antibody mAb 2 Heavy Chain Variable Region CDRH2

<400>  20

Trp Phe Tyr Pro Gly Asn Asn Asn Ile Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  21
<211>  10
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  Anti-DR5 Antibody mAb 2 Heavy Chain Variable Region CDRH3

<400>  21

His Glu Gln Gly Pro Gly Tyr Phe Asp Tyr 
1               5                   10  


<210>  22
<211>  357
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(357)
<223>  Polynucleotide Encoding Anti-DR5 Antibody mAb 2 Heavy Chain 
       Variable Region

<400>  22
aaggtccagc tgcagcagtc tggagctgaa ctggtgaaac ccggggcatc agtgaagctg       60

tcctgcaagg cttctgggta caccttcact gagtatattt tacactgggt aaagcagaag      120

tctggacagg gtcttgagtg gattgggtgg ttttatcctg gaaataataa tataaagtac      180

aatgagaaat tcaaggacaa ggccacactg actgcggaca aatcctccag cacagtctat      240

atggaactta gtagattgac atctgaagac tctgcggtct atttctgtgc aagacacgaa      300

caaggaccag gttactttga ctactggggc caaggcacca ctctcacagt ctcctcc         357


<210>  23
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-DR5 mAb 2 Light Chain Variable Region Variant 2

<400>  23

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  24
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding Humanized Anti-DR5 mAb 2 Light Chain 
       Variable Region Variant  2

<400>  24
gatattcaga tgacccagag tccctcattt ctgtccgcct ccgtcggtga ccgcgtgact       60

attacttgta aagcttctca ggatgtcaac accgccgtgg cttggtacca gcagaagccc      120

ggtaaagcac ctaagctgct gatctattgg gccagcactc ggcacaccgg agtcccatct      180

aggttctctg gcagtggatc agggacagac tttaccctga caattagctc cctgcagccc      240

gaggatgtgg ctacttacta ttgtcagcag cactacatca ctccttggac cttcggcggg      300

ggcacaaaac tggaaatcaa a                                                321


<210>  25
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-DR5 mAb 2 Light Chain Variable Region Variant 3

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  26
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding Humanized Anti-DR5 mAb 2 Light Chain 
       Variable Region Variant 3

<400>  26
gatattcaga tgacccagag tccctcattt ctgtccgcct ccgtcggtga ccgcgtgact       60

attacttgtc gggcttctca ggatgtcaac accgccgtgg cttggtacca gcagaagccc      120

ggtaaagcac ctaagctgct gatctattgg gccagcactc ggcacaccgg agtcccagat      180

aggttctctg gcagtggatc agggacagac tttaccctga caattagctc cctgcagccc      240

gaggatgtgg ctacttacta ttgtcagcag cactacatca ctccttggac cttcggcggg      300

ggcacaaaac tggaaatcaa a                                                321


<210>  27
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-DR5 mAb 2 Light Chain Variable Region Variant  4

<400>  27

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  28
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding Humanized Anti-DR5 mAb 2 Light Chain 
       Variable Region Variant 4

<400>  28
gatattcaga tgacccagag tccctcattt ctgtccgcct ccgtcggtga ccgcgtgact       60

attacttgtc gggcttctca ggatgtcaac accgccgtgg cttggtacca gcagaagccc      120

ggtaaagcac ctaagctgct gatctattgg gccagcactc ggcacaccgg agtcccatct      180

aggttctctg gcagtggatc agggacagac tttaccctga caattagctc cctgcagcca      240

gaggatatcg ctacatacta ttgtcagcag cactacatca ctccttggac cttcggcggg      300

ggcacaaaac tggaaatcaa a                                                321


<210>  29
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-DR5 mAb 2 Light Chain Variable Region Variant  5

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  30
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding Humanized Anti-DR5 mAb 2 Light Chain 
       Variable Region Variant 5

<400>  30
gatattcaga tgacccagag tccctcattt ctgtccgcct ccgtcggtga ccgcgtgact       60

attacttgtc gggcttctca ggatgtcaac accgccgtgg cttggtacca gcagaagccc      120

ggtaaagcac ctaagctgct gatctattgg gccagcactc ggcacaccgg agtcccagat      180

aggttctctg gcagtggatc agggacagac tttaccctga caattagctc cctgcagccc      240

gaggatatcg ctacttacta ttgtcagcag cactacatca ctccttggac cttcggcggg      300

ggcacaaaac tggaaatcaa a                                                321


<210>  31
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-DR5 mAb 2 Heavy Chain Variable Region Variant 2

<400>  31

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Ile Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Phe Tyr Pro Gly Asn Asn Asn Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Glu Gln Gly Pro Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  32
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding Humanized Anti-DR5 mAb 2 Heavy Chain 
       Variable Region Variant 2

<400>  32
caggtccagc tggtgcagag tggggcagag gtgaaaaagc caggggcatc agtgaaagtg       60

tcttgtaaag catcaggtta tacatttact gagtacatcc tgcactgggt gcgacaggca      120

ccaggacagg gactggaatg gatggggtgg ttctaccctg gcaacaacaa cattaagtac      180

aacgagaagt ttaaagaccg ggtgaccatc acagcggata agtctaccag tacagtctat      240

atggagctga gctccctgag aagcgaagac accgccgtct actattgcgc tcgccacgaa      300

cagggtccag gttactttga ttattggggg cagggaactc tggtcacagt cagctcc         357


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 1

<400>  33

Gly Gly Gly Ser Gly Gly Gly Gly 
1               5               


<210>  34
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine-Containing Domain ("Linker 2")

<400>  34

Gly Gly Cys Gly Gly Gly 
1               5       


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Cysteine-Containing Portion of Human IgG Hinge Domain

<400>  35

Gly Val Glu Pro Lys Ser Cys 
1               5           


<210>  36
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  Cysteine-Containing Portion of Human IgG Hinge Domain

<400>  36

Val Glu Pro Lys Ser Cys 
1               5       


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Cysteine-Containing Portion of Human CL Domain

<400>  37

Gly Phe Asn Arg Gly Glu Cys 
1               5           


<210>  38
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  Cysteine-Containing Portion of Human CL Domain

<400>  38

Phe Asn Arg Gly Glu Cys 
1               5       


<210>  39
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E-Coil Heterodimer-Promoting Domain

<400>  39

Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val 
1               5                   10                  15      


Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys 
            20                  25              


<210>  40
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K-Coil Heterodimer-Promoting Domain

<400>  40

Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val 
1               5                   10                  15      


Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu 
            20                  25              


<210>  41
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine-Containing E-Coil Heterodimer-Promoting Domain

<400>  41

Glu Val Ala Ala Cys Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val 
1               5                   10                  15      


Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys 
            20                  25              


<210>  42
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine-Containing K-Coil Heterodimer-Promoting Domain

<400>  42

Lys Val Ala Ala Cys Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val 
1               5                   10                  15      


Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu 
            20                  25              


<210>  43
<211>  46
<212>  PRT
<213>  Streptococcus dysgalactiae


<220>
<221>  MISC_FEATURE
<222>  (1)..(46)
<223>  Albumin-Binding Domain 3 (ABD3) of Protein G of Streptococcus

<400>  43

Leu Ala Glu Ala Lys Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly 
1               5                   10                  15      


Val Ser Asp Tyr Tyr Lys Asn Leu Ile Asp Asn Ala Lys Ser Ala Glu 
            20                  25                  30          


Gly Val Lys Ala Leu Ile Asp Glu Ile Leu Ala Ala Leu Pro 
        35                  40                  45      


<210>  44
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Deimmunized Albumin-Binding Domain 3 (ABD3) of Protein G 
       of Streptococcus Strain G148

<400>  44

Leu Ala Glu Ala Lys Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly 
1               5                   10                  15      


Val Ser Asp Tyr Tyr Lys Asn Ala Ala Asn Asn Ala Lys Thr Val Glu 
            20                  25                  30          


Gly Val Lys Ala Leu Ile Ala Glu Ile Leu Ala Ala Leu Pro 
        35                  40                  45      


<210>  45
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Deimmunized Albumin-Binding Domain 3 (ABD3) of Protein G 
       of Streptococcus Strain G148

<400>  45

Leu Ala Glu Ala Lys Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly 
1               5                   10                  15      


Val Ser Asp Tyr Tyr Lys Asn Leu Ile Ser Asn Ala Lys Ser Val Glu 
            20                  25                  30          


Gly Val Lys Ala Leu Ile Ala Glu Ile Leu Ala Ala Leu Pro 
        35                  40                  45      


<210>  46
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Linker

<400>  46

Gly Gly Gly Ser 
1               


<210>  47
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Linker

<400>  47

Ala Ser Thr Lys Gly 
1               5   


<210>  48
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine-Containing Peptide Linker ("Linker 3")

<400>  48

Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10  


<210>  49
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Linker ("Linker 3')

<400>  49

Leu Glu Pro Lys Ser Ser 
1               5       


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Linker ("Linker 3')

<400>  50

Ala Pro Ser Ser Ser Pro Met Glu 
1               5               


<210>  51
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative Cysteine-Containing Linker Peptide ("Linker 3")

<400>  51

Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


<210>  52
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  "Knob-Bearing" CH2-CH3 Domain

<400>  52

Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  53
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hole-Bearing" CH2-CH3 Domain

<400>  53

Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  54
<211>  108
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(108)
<223>  drozitumab anti-DR5 Antibody Light Chain Variable Region

<400>  54

Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
1               5                   10                  15      


Val Arg Ile Thr Cys Ser Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly 
        35                  40                  45              


Ala Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser 
    50                  55                  60                  


Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys Asn Ser Ala Asp Ser Ser Gly Asn His Val 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105             


<210>  55
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  drozitumab anti-DR5 Antibody Light Chain Variable Region CDRL1

<400>  55

Ser Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
1               5                   10      


<210>  56
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  drozitumab anti-DR5 Antibody Light Chain Variable Region CDRL2

<400>  56

Gly Ala Asn Asn Arg Pro Ser 
1               5           


<210>  57
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  drozitumab anti-DR5 Antibody Light Chain Variable Region CDRL3

<400>  57

Asn Ser Ala Asp Ser Ser Gly Asn His Val Val 
1               5                   10      


<210>  58
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(121)
<223>  drozitumab anti-DR5 Antibody Heavy Chain Variable Region

<400>  58

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Glu Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Gln Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ile Leu Gly Ala Gly Arg Gly Trp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  59
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  drozitumab anti-DR5 Antibody Heavy Chain Variable Region CDRH1

<400>  59

Gly Phe Thr Phe Asp Asp Tyr Ala Met Ser 
1               5                   10  


<210>  60
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  drozitumab anti-DR5 Antibody Heavy Chain Variable Region CDRH2

<400>  60

Ile Asn Trp Gln Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  61
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  drozitumab anti-DR5 Antibody Heavy Chain Variable Region CDRH3

<400>  61

Ile Leu Gly Ala Gly Arg Gly Trp Tyr Phe Asp Tyr 
1               5                   10          


<210>  62
<211>  108
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(108)
<223>  conatumumab anti-DR5 Antibody Light Chain Variable Region

<400>  62

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly Ile Ser Arg Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ser Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  63
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  conatumumab anti-DR5 Antibody Light Chain Variable Region CDRL1

<400>  63

Arg Ala Ser Gln Gly Ile Ser Arg Ser Tyr Leu Ala 
1               5                   10          


<210>  64
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  conatumumab anti-DR5 Antibody Light Chain Variable Region CDRL2

<400>  64

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  65
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  conatumumab anti-DR5 Antibody Light Chain Variable Region CDRL3

<400>  65

Gln Gln Phe Gly Ser Ser Pro Trp Thr 
1               5                   


<210>  66
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  conatumumab anti-DR5 Antibody Heavy Chain Variable Region

<400>  66

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Phe Trp Ser Trp Ile Arg Gln Leu Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile His Asn Ser Gly Thr Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Lys Gln Phe 
65                  70                  75                  80  


Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Gly Gly Asp Tyr Tyr Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  67
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  conatumumab anti-DR5 Antibody Heavy Chain Variable Region CDRH1

<400>  67

Gly Gly Ser Ile Ser Ser Gly Asp Tyr Phe Trp Ser 
1               5                   10          


<210>  68
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  conatumumab anti-DR5 Antibody Heavy Chain Variable Region CDRH2

<400>  68

His Ile His Asn Ser Gly Thr Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  69
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  conatumumab anti-DR5 Antibody Heavy Chain Variable Region CDRH3

<400>  69

Asp Arg Gly Gly Asp Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10          


<210>  70
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tigatumumab humanized anti-DR5 Antibody Light Chain Variable 
       Region

<400>  70

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Arg Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  71
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tigatumumab humanized anti-DR5 Antibody Light Chain Variable 
       Region CDRL1

<400>  71

Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  72
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tigatumumab humanized anti-DR5 Antibody Light Chain Variable 
       Region CDRL2

<400>  72

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  73
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tigatumumab humanized anti-DR5 Antibody Light Chain Variable 
       Region CDRL3

<400>  73

Gln Gln Tyr Ser Ser Tyr Arg Thr 
1               5               


<210>  74
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tigatumumab humanized anti-DR5 Antibody Heavy Chain Variable 
       Region

<400>  74

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Asp Ser Met Ile Thr Thr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  75
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tigatumumab humanized anti-DR5 Antibody Heavy Chain Variable 
       Region CDRH1

<400>  75

Gly Phe Thr Phe Ser Ser Tyr Val Met Ser 
1               5                   10  


<210>  76
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tigatumumab humanized anti-DR5 Antibody Heavy Chain Variable 
       Region CDRH3

<400>  76

Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  77
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tigatumumab humanized anti-DR5 Antibody Heavy Chain Variable 
       Region CDRH3

<400>  77

Arg Gly Asp Ser Met Ile Thr Thr Asp Tyr 
1               5                   10  


<210>  78
<211>  109
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(109)
<223>  LBY135-1 anti-DR5 Antibody Light Chain Variable Region

<400>  78

Asp Ile Ala Met Thr Gln Ser His Lys Phe Met Ser Thr Leu Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Tyr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Met Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala 
            100                 105                 


<210>  79
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  LBY135-1 anti-DR5 Antibody Light Chain Variable Region CDRL1

<400>  79

Gln Asp Val Asn Thr Ala Ile Ala 
1               5               


<210>  80
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  LBY135-1 anti-DR5 Antibody Light Chain Variable Region CDRL2

<400>  80

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  81
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  LBY135-1 anti-DR5 Antibody Light Chain Variable Region CDRL3

<400>  81

Gln Gln Trp Ser Ser Asn Pro Leu Thr 
1               5                   


<210>  82
<211>  118
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(118)
<223>  LBY135-1 anti-DR5 Antibody Heavy Chain Variable Region

<400>  82

Lys Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Arg Ser Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe Tyr Pro Gly Gly Gly Tyr Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Thr Ser Glu Gly Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Glu Glu Gly Ile Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  83
<211>  10
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  LBY135-1 anti-DR5 Antibody Heavy Chain Variable Region CDRH1

<400>  83

Gly Tyr Thr Phe Thr Asp Tyr Thr Ile His 
1               5                   10  


<210>  84
<211>  17
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  LBY135-1 anti-DR5 Antibody Heavy Chain Variable Region CDRH2

<400>  84

Trp Phe Tyr Pro Gly Gly Gly Tyr Ile Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  85
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  LBY135-1 anti-DR5 Antibody Heavy Chain Variable Region CDRH3

<400>  85

His Glu Glu Gly Ile Tyr Phe Asp Tyr 
1               5                   


<210>  86
<211>  104
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(104)
<223>  LBY135-2 anti-DR5 Antibody Light Chain Variable Region

<400>  86

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu 
            100                 


<210>  87
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  LBY135-2 anti-DR5 Antibody Light Chain Variable Region CDRL1

<400>  87

Lys Ala Ser Gln Asp Val Asn Thr Ala Ile Ala 
1               5                   10      


<210>  88
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  LBY135-2 anti-DR5 Antibody Light Chain Variable Region CDRL2

<400>  88

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  89
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  LBY135-2 anti-DR5 Antibody Light Chain Variable Region CDRL3

<400>  89

Gln Gln His Tyr Thr Thr Pro Phe Thr 
1               5                   


<210>  90
<211>  118
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(118)
<223>  LBY135-2 anti-DR5 Antibody Heavy Chain Variable Region

<400>  90

Lys Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Arg Ser Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe Tyr Pro Gly Gly Gly Tyr Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Glu Glu Gly Ile Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  91
<211>  10
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  LBY135-2 anti-DR5 Antibody Heavy Chain Variable Region CDRH1

<400>  91

Gly Tyr Thr Phe Thr Asp Tyr Thr Ile His 
1               5                   10  


<210>  92
<211>  17
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  LBY135-2 anti-DR5 Antibody Heavy Chain Variable Region CDRH2

<400>  92

Trp Phe Tyr Pro Gly Gly Gly Tyr Ile Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  93
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  LBY135-2 anti-DR5 Antibody Heavy Chain Variable Region CDRH3

<400>  93

His Glu Glu Gly Ile Tyr Phe Asp Tyr 
1               5                   


<210>  94
<211>  108
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(108)
<223>  KMTR2 anti-DR5 Antibody Light Chain Variable Region

<400>  94

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  95
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  KMTR2 anti-DR5 Antibody Light Chain Variable Region CDRL1

<400>  95

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  96
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  KMTR2 anti-DR5 Antibody Light Chain Variable Region CDRL2

<400>  96

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  97
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  KMTR2 anti-DR5 Antibody Light Chain Variable Region CDRL3

<400>  97

Gln Gln Arg Ser Asn Trp Pro Leu Thr 
1               5                   


<210>  98
<211>  126
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(126)
<223>  KMTR2 anti-DR5 Antibody Heavy Chain Variable Region

<400>  98

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Met Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Lys Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asp Thr Asp Ser Thr Gly Tyr Pro Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Tyr Gly Ser Gly Ser Tyr Tyr Arg Asp Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  99
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  KMTR2 anti-DR5 Antibody Heavy Chain Variable Region CDRH1

<400>  99

Gly Tyr Thr Phe Thr Asn Tyr Lys Ile Asn 
1               5                   10  


<210>  100
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  KMTR2 anti-DR5 Antibody Heavy Chain Variable Region CDRH2

<400>  100

Trp Met Asn Pro Asp Thr Asp Ser Thr Gly Tyr Pro Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  101
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  KMTR2 anti-DR5 Antibody Heavy Chain Variable Region CDRH3

<400>  101

Ser Tyr Gly Ser Gly Ser Tyr Tyr Arg Asp Tyr Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  102
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc Region L234A/L235A Variant

<400>  102

Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  103
<211>  217
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(217)
<223>  Human Wild-Type IgG4 CH2-CH3 Domain

<400>  103

Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    210                 215         


<210>  104
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-CD3 "mAb 2" Light Chain Variable Domain

<400>  104

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  105
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-CD3 "mAb 2" Light Chain Variable Domain CDRL1

<400>  105

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  106
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-CD3 "mAb 2" Light Chain Variable Domain CDRL2

<400>  106

Gly Thr Asn Lys Arg Ala Pro 
1               5           


<210>  107
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-CD3 "mAb 2" Light Chain Variable Domain CDRL3

<400>  107

Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210>  108
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-CD3 "mAb 2" Heavy Chain Variable Domain

<400>  108

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  109
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-CD3 "mAb 2" Heavy Chain Variable Domain CDRH1

<400>  109

Thr Tyr Ala Met Asn 
1               5   


<210>  110
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-CD3 "mAb 2" Heavy Chain Variable Domain CDRH2

<400>  110

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  111
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-CD3 "mAb 2" Heavy Chain Variable Domain CDRH3

<400>  111

His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  


<210>  112
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-CD3 "mAb 2" Heavy Chain Variable Domain D65G 
       Variant

<400>  112

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  113
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-CD3 "mAb 2" Heavy Chain Variable Domain D65G 
       Variant CDRH2

<400>  113

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  114
<211>  112
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(112)
<223>  Fluorescein antibody 4-4-20 Light Chain Variable Domain

<400>  114

Asp Val Val Met Thr Gln Thr Pro Phe Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Arg Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Val Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  115
<211>  118
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(118)
<223>  Fluorescein antibody 4-4-20 Heavy Chain Variable Domain

<400>  115

Glu Val Lys Leu Asp Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Pro Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gln Ile Arg Asn Lys Pro Tyr Asn Tyr Glu Thr Tyr Tyr Ser Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Val Glu Asp Met Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Gly Ser Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  116
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First Polypeptide Chain of an Exemplary DR5 mAb 1 x DR5 mAb 2 Fc 
       diabody

<400>  116

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Ser Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Val Leu Ile Phe Leu Ser Ser Asn Leu Asp Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Asp Gly Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Lys Val Gln Leu Gln Gln Ser Gly Ala 
        115                 120                 125             


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser 
    130                 135                 140                 


Gly Tyr Thr Phe Thr Glu Tyr Ile Leu His Trp Val Lys Gln Lys Ser 
145                 150                 155                 160 


Gly Gln Gly Leu Glu Trp Ile Gly Trp Phe Tyr Pro Gly Asn Asn Asn 
                165                 170                 175     


Ile Lys Tyr Asn Glu Lys Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp 
            180                 185                 190         


Lys Ser Ser Ser Thr Val Tyr Met Glu Leu Ser Arg Leu Thr Ser Glu 
        195                 200                 205             


Asp Ser Ala Val Tyr Phe Cys Ala Arg His Glu Gln Gly Pro Gly Tyr 
    210                 215                 220                 


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser 
225                 230                 235                 240 


Thr Lys Gly Glu Val Ala Ala Cys Glu Lys Glu Val Ala Ala Leu Glu 
                245                 250                 255     


Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Leu 
            260                 265                 270         


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        275                 280                 285             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    290                 295                 300                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
305                 310                 315                 320 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                325                 330                 335     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            340                 345                 350         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        355                 360                 365             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    370                 375                 380                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
385                 390                 395                 400 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
                405                 410                 415     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            420                 425                 430         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        435                 440                 445             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    450                 455                 460                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
465                 470                 475                 480 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                485                 490                 495     


Ser Leu Ser Leu Ser Pro Gly 
            500             


<210>  117
<211>  1509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding First Polypeptide Chain of an Exemplary 
       DR5 mAb 1 x DR5 mAb 2 Fc diabody

<400>  117
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctcgggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt tcctctggct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaagtc ctcatctttc tttcatccaa cctagattct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg atggggatgc tgcaacctat tactgtcagc acagtaggga tcttcctccg      300

acgttcggtg gaggcaccaa gctggaaatc aaaggaggcg gatccggcgg cggaggcaag      360

gtccagctgc agcagtctgg agctgaactg gtgaaacccg gggcatcagt gaagctgtcc      420

tgcaaggctt ctgggtacac cttcactgag tatattttac actgggtaaa gcagaagtct      480

ggacagggtc ttgagtggat tgggtggttt tatcctggaa ataataatat aaagtacaat      540

gagaaattca aggacaaggc cacactgact gcggacaaat cctccagcac agtctatatg      600

gaacttagta gattgacatc tgaagactct gcggtctatt tctgtgcaag acacgaacaa      660

ggaccaggtt actttgacta ctggggccaa ggcaccactc tcacagtctc ctccgcctcc      720

accaagggcg aagtggccgc atgtgagaaa gaggttgctg ctttggagaa ggaggtcgct      780

gcacttgaaa aggaggtcgc agccctggag aaactggagc ccaaatcttc tgacaaaact      840

cacacatgcc caccgtgccc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc      900

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      960

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     1020

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc     1080

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc     1140

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1200

cgagaaccac aggtgtacac cctgccccca tcccgggagg agatgaccaa gaaccaggtc     1260

agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     1320

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1380

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1440

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1500

tctccgggt                                                             1509


<210>  118
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second Polypeptide Chain of an Exemplary DR5 mAb 1 x DR5 mAb 2 Fc
       diabody

<400>  118

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Lys Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Thr Leu Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Glu Val Lys Phe Leu Glu Ser Gly Gly Gly Leu Val Gln 
        115                 120                 125             


Pro Gly Gly Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Asp Phe 
    130                 135                 140                 


Ser Arg Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
145                 150                 155                 160 


Glu Trp Ile Gly Glu Ile Asn Pro Asp Ser Asn Thr Ile Asn Tyr Thr 
                165                 170                 175     


Pro Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn 
            180                 185                 190         


Thr Leu Tyr Leu Gln Met Thr Lys Val Arg Ser Glu Asp Thr Ala Leu 
        195                 200                 205             


Tyr Tyr Cys Thr Arg Arg Ala Tyr Tyr Gly Asn Pro Ala Trp Phe Ala 
    210                 215                 220                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys 
225                 230                 235                 240 


Gly Lys Val Ala Ala Cys Lys Glu Lys Val Ala Ala Leu Lys Glu Lys 
                245                 250                 255     


Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu 
            260                 265                 


<210>  119
<211>  807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding Second Polypeptide Chain of an Exemplary 
       DR5 mAb 1 x DR5 mAb 2 Fc diabody

<400>  119
gacattgtga tgacccagtc tcacaaattc atgtccactt cagtaggaga cagggtcagc       60

atcacctgca aggccagtca ggatgtgaat actgctgtag cctggtatca acaaaaacca      120

gggcaatctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat tatacactca ccatcaaaag tgtgcaggct      240

gaagacctga cactttatta ctgtcagcaa cactatatca ctccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa aggaggcgga tccggcggcg gaggcgaggt gaagtttctc      360

gagtctggag gtggcctggt gcagcctgga ggatccctga aactctcctg tgtagcctca      420

ggattcgatt ttagtagata ctggatgagt tgggtccggc aggctccagg gaaagggcta      480

gaatggattg gagaaattaa tccagatagc aatacgataa actatacgcc atctctaaag      540

gataaattca tcatctccag agacaacgcc aaaaatacgc tgtatctgca aatgaccaaa      600

gtgagatctg aggacacagc cctttattat tgtacaagaa gggcctacta tggtaacccg      660

gcctggtttg cttactgggg ccaagggact ctggtcactg tctctgcagc ctccaccaag      720

ggcaaagtgg ccgcatgtaa ggagaaagtt gctgctttga aagagaaggt cgccgcactt      780

aaggaaaagg tcgcagccct gaaagag                                          807


<210>  120
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First Polypeptide Chain of an Exemplary DR5 mAb 1 x DR5 mAb 2 Fc 
       diabody L234A/L235A

<400>  120

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Ser Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Val Leu Ile Phe Leu Ser Ser Asn Leu Asp Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Asp Gly Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Lys Val Gln Leu Gln Gln Ser Gly Ala 
        115                 120                 125             


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser 
    130                 135                 140                 


Gly Tyr Thr Phe Thr Glu Tyr Ile Leu His Trp Val Lys Gln Lys Ser 
145                 150                 155                 160 


Gly Gln Gly Leu Glu Trp Ile Gly Trp Phe Tyr Pro Gly Asn Asn Asn 
                165                 170                 175     


Ile Lys Tyr Asn Glu Lys Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp 
            180                 185                 190         


Lys Ser Ser Ser Thr Val Tyr Met Glu Leu Ser Arg Leu Thr Ser Glu 
        195                 200                 205             


Asp Ser Ala Val Tyr Phe Cys Ala Arg His Glu Gln Gly Pro Gly Tyr 
    210                 215                 220                 


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser 
225                 230                 235                 240 


Thr Lys Gly Glu Val Ala Ala Cys Glu Lys Glu Val Ala Ala Leu Glu 
                245                 250                 255     


Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Leu 
            260                 265                 270         


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        275                 280                 285             


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    290                 295                 300                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
305                 310                 315                 320 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                325                 330                 335     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            340                 345                 350         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        355                 360                 365             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    370                 375                 380                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
385                 390                 395                 400 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
                405                 410                 415     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            420                 425                 430         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        435                 440                 445             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    450                 455                 460                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
465                 470                 475                 480 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                485                 490                 495     


Ser Leu Ser Leu Ser Pro Gly 
            500             


<210>  121
<211>  1509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding First Polypeptide Chain of an Exemplary 
       DR5 mAb 1 x DR5 mAb 2 Fc diabody L234A/L235A

<400>  121
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctcgggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt tcctctggct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaagtc ctcatctttc tttcatccaa cctagattct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg atggggatgc tgcaacctat tactgtcagc acagtaggga tcttcctccg      300

acgttcggtg gaggcaccaa gctggaaatc aaaggaggcg gatccggcgg cggaggcaag      360

gtccagctgc agcagtctgg agctgaactg gtgaaacccg gggcatcagt gaagctgtcc      420

tgcaaggctt ctgggtacac cttcactgag tatattttac actgggtaaa gcagaagtct      480

ggacagggtc ttgagtggat tgggtggttt tatcctggaa ataataatat aaagtacaat      540

gagaaattca aggacaaggc cacactgact gcggacaaat cctccagcac agtctatatg      600

gaacttagta gattgacatc tgaagactct gcggtctatt tctgtgcaag acacgaacaa      660

ggaccaggtt actttgacta ctggggccaa ggcaccactc tcacagtctc ctccgcctcc      720

accaagggcg aagtggccgc atgtgagaaa gaggttgctg ctttggagaa ggaggtcgct      780

gcacttgaaa aggaggtcgc agccctggag aaactggagc ccaaatcttc tgacaaaact      840

cacacatgcc caccgtgccc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc      900

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      960

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     1020

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc     1080

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc     1140

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1200

cgagaaccac aggtgtacac cctgccccca tcccgggagg agatgaccaa gaaccaggtc     1260

agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     1320

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1380

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1440

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1500

tctccgggt                                                             1509


<210>  122
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First Polypeptide Chain of an Exemplary DR5 mAb 2 x DR5 mAb 1 Fc 
       diabody

<400>  122

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Lys Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Thr Leu Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Glu Val Lys Phe Leu Glu Ser Gly Gly Gly Leu Val Gln 
        115                 120                 125             


Pro Gly Gly Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Asp Phe 
    130                 135                 140                 


Ser Arg Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
145                 150                 155                 160 


Glu Trp Ile Gly Glu Ile Asn Pro Asp Ser Asn Thr Ile Asn Tyr Thr 
                165                 170                 175     


Pro Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn 
            180                 185                 190         


Thr Leu Tyr Leu Gln Met Thr Lys Val Arg Ser Glu Asp Thr Ala Leu 
        195                 200                 205             


Tyr Tyr Cys Thr Arg Arg Ala Tyr Tyr Gly Asn Pro Ala Trp Phe Ala 
    210                 215                 220                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys 
225                 230                 235                 240 


Gly Glu Val Ala Ala Cys Glu Lys Glu Val Ala Ala Leu Glu Lys Glu 
                245                 250                 255     


Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Leu Glu Pro 
            260                 265                 270         


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    370                 375                 380                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Pro Gly 
            500     


<210>  123
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding First Polypeptide Chain of an Exemplary 
       DR5 mAb 2 x DR5 mAb 1 Fc diabody

<400>  123
gacattgtga tgacccagtc tcacaaattc atgtccactt cagtaggaga cagggtcagc       60

atcacctgca aggccagtca ggatgtgaat actgctgtag cctggtatca acaaaaacca      120

gggcaatctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat tatacactca ccatcaaaag tgtgcaggct      240

gaagacctga cactttatta ctgtcagcaa cactatatca ctccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa aggaggcgga tccggcggcg gaggcgaggt gaagtttctc      360

gagtctggag gtggcctggt gcagcctgga ggatccctga aactctcctg tgtagcctca      420

ggattcgatt ttagtagata ctggatgagt tgggtccggc aggctccagg gaaagggcta      480

gaatggattg gagaaattaa tccagatagc aatacgataa actatacgcc atctctaaag      540

gataaattca tcatctccag agacaacgcc aaaaatacgc tgtatctgca aatgaccaaa      600

gtgagatctg aggacacagc cctttattat tgtacaagaa gggcctacta tggtaacccg      660

gcctggtttg cttactgggg ccaagggact ctggtcactg tctctgcagc ctccaccaag      720

ggcgaagtgg ccgcatgtga gaaagaggtt gctgctttgg agaaggaggt cgctgcactt      780

gaaaaggagg tcgcagccct ggagaaactg gagcccaaat cttctgacaa aactcacaca      840

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca      900

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      960

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1020

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1080

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1140

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1200

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg     1260

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1320

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1380

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1440

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1500

ggt                                                                   1503


<210>  124
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second Polypeptide Chain of an Exemplary DR5 mAb 2 x DR5 mAb 1 Fc
       diabody

<400>  124

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Ser Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Val Leu Ile Phe Leu Ser Ser Asn Leu Asp Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Asp Gly Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Lys Val Gln Leu Gln Gln Ser Gly Ala 
        115                 120                 125             


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser 
    130                 135                 140                 


Gly Tyr Thr Phe Thr Glu Tyr Ile Leu His Trp Val Lys Gln Lys Ser 
145                 150                 155                 160 


Gly Gln Gly Leu Glu Trp Ile Gly Trp Phe Tyr Pro Gly Asn Asn Asn 
                165                 170                 175     


Ile Lys Tyr Asn Glu Lys Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp 
            180                 185                 190         


Lys Ser Ser Ser Thr Val Tyr Met Glu Leu Ser Arg Leu Thr Ser Glu 
        195                 200                 205             


Asp Ser Ala Val Tyr Phe Cys Ala Arg His Glu Gln Gly Pro Gly Tyr 
    210                 215                 220                 


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser 
225                 230                 235                 240 


Thr Lys Gly Lys Val Ala Ala Cys Lys Glu Lys Val Ala Ala Leu Lys 
                245                 250                 255     


Glu Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu 
            260                 265                 270     


<210>  125
<211>  813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding Second Polypeptide Chain of an Exemplary 
       DR5 mAb 2 x DR5 mAb 1 Fc diabody

<400>  125
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctcgggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt tcctctggct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaagtc ctcatctttc tttcatccaa cctagattct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg atggggatgc tgcaacctat tactgtcagc acagtaggga tcttcctccg      300

acgttcggtg gaggcaccaa gctggaaatc aaaggaggcg gatccggcgg cggaggcaag      360

gtccagctgc agcagtctgg agctgaactg gtgaaacccg gggcatcagt gaagctgtcc      420

tgcaaggctt ctgggtacac cttcactgag tatattttac actgggtaaa gcagaagtct      480

ggacagggtc ttgagtggat tgggtggttt tatcctggaa ataataatat aaagtacaat      540

gagaaattca aggacaaggc cacactgact gcggacaaat cctccagcac agtctatatg      600

gaacttagta gattgacatc tgaagactct gcggtctatt tctgtgcaag acacgaacaa      660

ggaccaggtt actttgacta ctggggccaa ggcaccactc tcacagtctc ctccgcctcc      720

accaagggca aagtggccgc atgtaaggag aaagttgctg ctttgaaaga gaaggtcgcc      780

gcacttaagg aaaaggtcgc agccctgaaa gag                                   813


<210>  126
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First Polypeptide Chain of an Exemplary DR5 mAb 2 x DR5 mAb 1 Fc 
       diabody L234A/L235A

<400>  126

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Lys Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Thr Leu Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Glu Val Lys Phe Leu Glu Ser Gly Gly Gly Leu Val Gln 
        115                 120                 125             


Pro Gly Gly Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Asp Phe 
    130                 135                 140                 


Ser Arg Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
145                 150                 155                 160 


Glu Trp Ile Gly Glu Ile Asn Pro Asp Ser Asn Thr Ile Asn Tyr Thr 
                165                 170                 175     


Pro Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn 
            180                 185                 190         


Thr Leu Tyr Leu Gln Met Thr Lys Val Arg Ser Glu Asp Thr Ala Leu 
        195                 200                 205             


Tyr Tyr Cys Thr Arg Arg Ala Tyr Tyr Gly Asn Pro Ala Trp Phe Ala 
    210                 215                 220                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys 
225                 230                 235                 240 


Gly Glu Val Ala Ala Cys Glu Lys Glu Val Ala Ala Leu Glu Lys Glu 
                245                 250                 255     


Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Leu Glu Pro 
            260                 265                 270         


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    370                 375                 380                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Pro Gly 
            500     


<210>  127
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding First Polypeptide Chain of an Exemplary 
       DR5 mAb 2 x DR5 mAb 1 Fc diabody L234A/L235A

<400>  127
gacattgtga tgacccagtc tcacaaattc atgtccactt cagtaggaga cagggtcagc       60

atcacctgca aggccagtca ggatgtgaat actgctgtag cctggtatca acaaaaacca      120

gggcaatctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat tatacactca ccatcaaaag tgtgcaggct      240

gaagacctga cactttatta ctgtcagcaa cactatatca ctccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa aggaggcgga tccggcggcg gaggcgaggt gaagtttctc      360

gagtctggag gtggcctggt gcagcctgga ggatccctga aactctcctg tgtagcctca      420

ggattcgatt ttagtagata ctggatgagt tgggtccggc aggctccagg gaaagggcta      480

gaatggattg gagaaattaa tccagatagc aatacgataa actatacgcc atctctaaag      540

gataaattca tcatctccag agacaacgcc aaaaatacgc tgtatctgca aatgaccaaa      600

gtgagatctg aggacacagc cctttattat tgtacaagaa gggcctacta tggtaacccg      660

gcctggtttg cttactgggg ccaagggact ctggtcactg tctctgcagc ctccaccaag      720

ggcgaagtgg ccgcatgtga gaaagaggtt gctgctttgg agaaggaggt cgctgcactt      780

gaaaaggagg tcgcagccct ggagaaactg gagcccaaat cttctgacaa aactcacaca      840

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca      900

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      960

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1020

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1080

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1140

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1200

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg     1260

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1320

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1380

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1440

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1500

ggt                                                                   1503


<210>  128
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First Polypeptide Chain of an Exemplary DR5 mAb 1 x DR5 mAb 1 Fc 
       diabody

<400>  128

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Ser Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Val Leu Ile Phe Leu Ser Ser Asn Leu Asp Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Asp Gly Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Glu Val Lys Phe Leu Glu Ser Gly Gly 
        115                 120                 125             


Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Val Ala Ser 
    130                 135                 140                 


Gly Phe Asp Phe Ser Arg Tyr Trp Met Ser Trp Val Arg Gln Ala Pro 
145                 150                 155                 160 


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Asn Pro Asp Ser Asn Thr 
                165                 170                 175     


Ile Asn Tyr Thr Pro Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp 
            180                 185                 190         


Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Thr Lys Val Arg Ser Glu 
        195                 200                 205             


Asp Thr Ala Leu Tyr Tyr Cys Thr Arg Arg Ala Tyr Tyr Gly Asn Pro 
    210                 215                 220                 


Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
225                 230                 235                 240 


Ala Ser Thr Lys Gly Glu Val Ala Ala Cys Glu Lys Glu Val Ala Ala 
                245                 250                 255     


Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu 
            260                 265                 270         


Lys Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
        275                 280                 285             


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    290                 295                 300                 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
305                 310                 315                 320 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
                325                 330                 335     


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
            340                 345                 350         


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
        355                 360                 365             


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
    370                 375                 380                 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
385                 390                 395                 400 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
                405                 410                 415     


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            420                 425                 430         


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        435                 440                 445             


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    450                 455                 460                 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
465                 470                 475                 480 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                485                 490                 495     


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            500                 505 


<210>  129
<211>  1515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding First Polypeptide Chain of an Exemplary 
       DR5 mAb 1 x DR5 mAb 1 Fc diabody

<400>  129
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctcgggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt tcctctggct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaagtc ctcatctttc tttcatccaa cctagattct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg atggggatgc tgcaacctat tactgtcagc acagtaggga tcttcctccg      300

acgttcggtg gaggcaccaa gctggaaatc aaaggaggcg gatccggcgg cggaggcgag      360

gtgaagtttc tcgagtctgg aggtggcctg gtgcagcctg gaggatccct gaaactctcc      420

tgtgtagcct caggattcga ttttagtaga tactggatga gttgggtccg gcaggctcca      480

gggaaagggc tagaatggat tggagaaatt aatccagata gcaatacgat aaactatacg      540

ccatctctaa aggataaatt catcatctcc agagacaacg ccaaaaatac gctgtatctg      600

caaatgacca aagtgagatc tgaggacaca gccctttatt attgtacaag aagggcctac      660

tatggtaacc cggcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      720

gcctccacca agggcgaagt ggccgcatgt gagaaagagg ttgctgcttt ggagaaggag      780

gtcgctgcac ttgaaaagga ggtcgcagcc ctggagaaac tggagcccaa atcttctgac      840

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc      900

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      960

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc     1020

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt     1080

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     1140

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     1200

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac     1260

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1320

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1380

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1440

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1500

tccctgtctc cgggt                                                      1515


<210>  130
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second Polypeptide Chain of an Exemplary DR5 mAb 1 x DR5 mAb 1 Fc
       diabody

<400>  130

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Ser Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Val Leu Ile Phe Leu Ser Ser Asn Leu Asp Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Asp Gly Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Glu Val Lys Phe Leu Glu Ser Gly Gly 
        115                 120                 125             


Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Val Ala Ser 
    130                 135                 140                 


Gly Phe Asp Phe Ser Arg Tyr Trp Met Ser Trp Val Arg Gln Ala Pro 
145                 150                 155                 160 


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Asn Pro Asp Ser Asn Thr 
                165                 170                 175     


Ile Asn Tyr Thr Pro Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp 
            180                 185                 190         


Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Thr Lys Val Arg Ser Glu 
        195                 200                 205             


Asp Thr Ala Leu Tyr Tyr Cys Thr Arg Arg Ala Tyr Tyr Gly Asn Pro 
    210                 215                 220                 


Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
225                 230                 235                 240 


Ala Ser Thr Lys Gly Lys Val Ala Ala Cys Lys Glu Lys Val Ala Ala 
                245                 250                 255     


Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys 
            260                 265                 270         


Glu 
    


<210>  131
<211>  819
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding Second Polypeptide Chain of an Exemplary 
       DR5 mAb 1 x DR5 mAb 1 Fc diabody

<400>  131
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctcgggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt tcctctggct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaagtc ctcatctttc tttcatccaa cctagattct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg atggggatgc tgcaacctat tactgtcagc acagtaggga tcttcctccg      300

acgttcggtg gaggcaccaa gctggaaatc aaaggaggcg gatccggcgg cggaggcgag      360

gtgaagtttc tcgagtctgg aggtggcctg gtgcagcctg gaggatccct gaaactctcc      420

tgtgtagcct caggattcga ttttagtaga tactggatga gttgggtccg gcaggctcca      480

gggaaagggc tagaatggat tggagaaatt aatccagata gcaatacgat aaactatacg      540

ccatctctaa aggataaatt catcatctcc agagacaacg ccaaaaatac gctgtatctg      600

caaatgacca aagtgagatc tgaggacaca gccctttatt attgtacaag aagggcctac      660

tatggtaacc cggcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      720

gcctccacca agggcaaagt ggccgcatgt aaggagaaag ttgctgcttt gaaagagaag      780

gtcgccgcac ttaaggaaaa ggtcgcagcc ctgaaagag                             819


<210>  132
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First Polypeptide Chain of an Exemplary DR5 mAb 1 x DR5 mAb 1 Fc 
       diabody L234A/L235A

<400>  132

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Ser Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Val Leu Ile Phe Leu Ser Ser Asn Leu Asp Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Asp Gly Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Glu Val Lys Phe Leu Glu Ser Gly Gly 
        115                 120                 125             


Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Val Ala Ser 
    130                 135                 140                 


Gly Phe Asp Phe Ser Arg Tyr Trp Met Ser Trp Val Arg Gln Ala Pro 
145                 150                 155                 160 


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Asn Pro Asp Ser Asn Thr 
                165                 170                 175     


Ile Asn Tyr Thr Pro Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp 
            180                 185                 190         


Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Thr Lys Val Arg Ser Glu 
        195                 200                 205             


Asp Thr Ala Leu Tyr Tyr Cys Thr Arg Arg Ala Tyr Tyr Gly Asn Pro 
    210                 215                 220                 


Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
225                 230                 235                 240 


Ala Ser Thr Lys Gly Glu Val Ala Ala Cys Glu Lys Glu Val Ala Ala 
                245                 250                 255     


Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu 
            260                 265                 270         


Lys Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
        275                 280                 285             


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    290                 295                 300                 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
305                 310                 315                 320 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
                325                 330                 335     


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
            340                 345                 350         


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
        355                 360                 365             


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
    370                 375                 380                 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
385                 390                 395                 400 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
                405                 410                 415     


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            420                 425                 430         


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        435                 440                 445             


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    450                 455                 460                 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
465                 470                 475                 480 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                485                 490                 495     


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            500                 505 


<210>  133
<211>  1515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding First Polypeptide Chain of an Exemplary 
       DR5 mAb 1 x DR5 mAb 1 Fc diabody L234A/L235A

<400>  133
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctcgggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt tcctctggct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaagtc ctcatctttc tttcatccaa cctagattct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg atggggatgc tgcaacctat tactgtcagc acagtaggga tcttcctccg      300

acgttcggtg gaggcaccaa gctggaaatc aaaggaggcg gatccggcgg cggaggcgag      360

gtgaagtttc tcgagtctgg aggtggcctg gtgcagcctg gaggatccct gaaactctcc      420

tgtgtagcct caggattcga ttttagtaga tactggatga gttgggtccg gcaggctcca      480

gggaaagggc tagaatggat tggagaaatt aatccagata gcaatacgat aaactatacg      540

ccatctctaa aggataaatt catcatctcc agagacaacg ccaaaaatac gctgtatctg      600

caaatgacca aagtgagatc tgaggacaca gccctttatt attgtacaag aagggcctac      660

tatggtaacc cggcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      720

gcctccacca agggcgaagt ggccgcatgt gagaaagagg ttgctgcttt ggagaaggag      780

gtcgctgcac ttgaaaagga ggtcgcagcc ctggagaaac tggagcccaa atcttctgac      840

aaaactcaca catgcccacc gtgcccagca cctgaagccg cggggggacc gtcagtcttc      900

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      960

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc     1020

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt     1080

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     1140

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     1200

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac     1260

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1320

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1380

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1440

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1500

tccctgtctc cgggt                                                      1515


<210>  134
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First Polypeptide Chain of an Exemplary DR5 mAb 2 x DR5 mAb 2 Fc 
       diabody

<400>  134

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Lys Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Thr Leu Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Lys Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys 
        115                 120                 125             


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    130                 135                 140                 


Thr Glu Tyr Ile Leu His Trp Val Lys Gln Lys Ser Gly Gln Gly Leu 
145                 150                 155                 160 


Glu Trp Ile Gly Trp Phe Tyr Pro Gly Asn Asn Asn Ile Lys Tyr Asn 
                165                 170                 175     


Glu Lys Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
            180                 185                 190         


Thr Val Tyr Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val 
        195                 200                 205             


Tyr Phe Cys Ala Arg His Glu Gln Gly Pro Gly Tyr Phe Asp Tyr Trp 
    210                 215                 220                 


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Glu 
225                 230                 235                 240 


Val Ala Ala Cys Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala 
                245                 250                 255     


Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Leu Glu Pro Lys Ser 
            260                 265                 270         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly 
            


<210>  135
<211>  1497
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding First Polypeptide Chain of an Exemplary 
       DR5 mAb 2 x DR5 mAb 2 Fc diabody

<400>  135
gacattgtga tgacccagtc tcacaaattc atgtccactt cagtaggaga cagggtcagc       60

atcacctgca aggccagtca ggatgtgaat actgctgtag cctggtatca acaaaaacca      120

gggcaatctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat tatacactca ccatcaaaag tgtgcaggct      240

gaagacctga cactttatta ctgtcagcaa cactatatca ctccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa aggaggcgga tccggcggcg gaggcaaggt ccagctgcag      360

cagtctggag ctgaactggt gaaacccggg gcatcagtga agctgtcctg caaggcttct      420

gggtacacct tcactgagta tattttacac tgggtaaagc agaagtctgg acagggtctt      480

gagtggattg ggtggtttta tcctggaaat aataatataa agtacaatga gaaattcaag      540

gacaaggcca cactgactgc ggacaaatcc tccagcacag tctatatgga acttagtaga      600

ttgacatctg aagactctgc ggtctatttc tgtgcaagac acgaacaagg accaggttac      660

tttgactact ggggccaagg caccactctc acagtctcct ccgcctccac caagggcgaa      720

gtggccgcat gtgagaaaga ggttgctgct ttggagaagg aggtcgctgc acttgaaaag      780

gaggtcgcag ccctggagaa actggagccc aaatcttctg acaaaactca cacatgccca      840

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc      900

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      960

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1020

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1080

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1140

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1200

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1260

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1320

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1380

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1440

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggt        1497


<210>  136
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second Polypeptide Chain of an Exemplary DR5 mAb 2 x DR5 mAb 2 Fc
       diabody

<400>  136

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Lys Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Thr Leu Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Lys Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys 
        115                 120                 125             


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    130                 135                 140                 


Thr Glu Tyr Ile Leu His Trp Val Lys Gln Lys Ser Gly Gln Gly Leu 
145                 150                 155                 160 


Glu Trp Ile Gly Trp Phe Tyr Pro Gly Asn Asn Asn Ile Lys Tyr Asn 
                165                 170                 175     


Glu Lys Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
            180                 185                 190         


Thr Val Tyr Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val 
        195                 200                 205             


Tyr Phe Cys Ala Arg His Glu Gln Gly Pro Gly Tyr Phe Asp Tyr Trp 
    210                 215                 220                 


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Lys 
225                 230                 235                 240 


Val Ala Ala Cys Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val Ala 
                245                 250                 255     


Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu 
            260                 265         


<210>  137
<211>  801
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding Second Polypeptide Chain of an Exemplary 
       DR5 mAb 2 x DR5 mAb 2 Fc diabody

<400>  137
gacattgtga tgacccagtc tcacaaattc atgtccactt cagtaggaga cagggtcagc       60

atcacctgca aggccagtca ggatgtgaat actgctgtag cctggtatca acaaaaacca      120

gggcaatctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat tatacactca ccatcaaaag tgtgcaggct      240

gaagacctga cactttatta ctgtcagcaa cactatatca ctccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa aggaggcgga tccggcggcg gaggcaaggt ccagctgcag      360

cagtctggag ctgaactggt gaaacccggg gcatcagtga agctgtcctg caaggcttct      420

gggtacacct tcactgagta tattttacac tgggtaaagc agaagtctgg acagggtctt      480

gagtggattg ggtggtttta tcctggaaat aataatataa agtacaatga gaaattcaag      540

gacaaggcca cactgactgc ggacaaatcc tccagcacag tctatatgga acttagtaga      600

ttgacatctg aagactctgc ggtctatttc tgtgcaagac acgaacaagg accaggttac      660

tttgactact ggggccaagg caccactctc acagtctcct ccgcctccac caagggcaaa      720

gtggccgcat gtaaggagaa agttgctgct ttgaaagaga aggtcgccgc acttaaggaa      780

aaggtcgcag ccctgaaaga g                                                801


<210>  138
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First Polypeptide Chain of an Exemplary DR5 mAb 2 x DR5 mAb 2 Fc 
       diabody L234A/L235A

<400>  138

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Lys Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Thr Leu Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Lys Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys 
        115                 120                 125             


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    130                 135                 140                 


Thr Glu Tyr Ile Leu His Trp Val Lys Gln Lys Ser Gly Gln Gly Leu 
145                 150                 155                 160 


Glu Trp Ile Gly Trp Phe Tyr Pro Gly Asn Asn Asn Ile Lys Tyr Asn 
                165                 170                 175     


Glu Lys Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
            180                 185                 190         


Thr Val Tyr Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val 
        195                 200                 205             


Tyr Phe Cys Ala Arg His Glu Gln Gly Pro Gly Tyr Phe Asp Tyr Trp 
    210                 215                 220                 


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Glu 
225                 230                 235                 240 


Val Ala Ala Cys Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala 
                245                 250                 255     


Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Leu Glu Pro Lys Ser 
            260                 265                 270         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly 
            


<210>  139
<211>  1497
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding First Polypeptide Chain of an Exemplary 
       DR5 mAb 2 x DR5 mAb 2 Fc diabody L234A/L235A

<400>  139
gacattgtga tgacccagtc tcacaaattc atgtccactt cagtaggaga cagggtcagc       60

atcacctgca aggccagtca ggatgtgaat actgctgtag cctggtatca acaaaaacca      120

gggcaatctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat tatacactca ccatcaaaag tgtgcaggct      240

gaagacctga cactttatta ctgtcagcaa cactatatca ctccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa aggaggcgga tccggcggcg gaggcaaggt ccagctgcag      360

cagtctggag ctgaactggt gaaacccggg gcatcagtga agctgtcctg caaggcttct      420

gggtacacct tcactgagta tattttacac tgggtaaagc agaagtctgg acagggtctt      480

gagtggattg ggtggtttta tcctggaaat aataatataa agtacaatga gaaattcaag      540

gacaaggcca cactgactgc ggacaaatcc tccagcacag tctatatgga acttagtaga      600

ttgacatctg aagactctgc ggtctatttc tgtgcaagac acgaacaagg accaggttac      660

tttgactact ggggccaagg caccactctc acagtctcct ccgcctccac caagggcgaa      720

gtggccgcat gtgagaaaga ggttgctgct ttggagaagg aggtcgctgc acttgaaaag      780

gaggtcgcag ccctggagaa actggagccc aaatcttctg acaaaactca cacatgccca      840

ccgtgcccag cacctgaagc cgcgggggga ccgtcagtct tcctcttccc cccaaaaccc      900

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      960

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1020

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1080

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1140

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1200

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1260

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1320

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1380

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1440

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggt        1497


<210>  140
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First Polypeptide Chain of an Exemplary hDR5 mAb 2.2 x hDR5 mAb 
       2.2 Fc diabody

<400>  140

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        115                 120                 125             


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    130                 135                 140                 


Thr Glu Tyr Ile Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
145                 150                 155                 160 


Glu Trp Met Gly Trp Phe Tyr Pro Gly Asn Asn Asn Ile Lys Tyr Asn 
                165                 170                 175     


Glu Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
            180                 185                 190         


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
        195                 200                 205             


Tyr Tyr Cys Ala Arg His Glu Gln Gly Pro Gly Tyr Phe Asp Tyr Trp 
    210                 215                 220                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Glu 
225                 230                 235                 240 


Val Ala Ala Cys Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala 
                245                 250                 255     


Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Leu Glu Pro Lys Ser 
            260                 265                 270         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly 
            


<210>  141
<211>  1497
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding First Polypeptide Chain of an Exemplary 
       hDR5 mAb 2.2 x hDR5 mAb 2.2 Fc diabody

<400>  141
gatattcaga tgacccagag tccctcattt ctgtccgcct ccgtcggtga ccgcgtgact       60

attacttgta aagcttctca ggatgtcaac accgccgtgg cttggtacca gcagaagccc      120

ggtaaagcac ctaagctgct gatctattgg gccagcactc ggcacaccgg agtcccatct      180

aggttctctg gcagtggatc agggacagac tttaccctga caattagctc cctgcagccc      240

gaggatgtgg ctacttacta ttgtcagcag cactacatca ctccttggac cttcggcggg      300

ggcacaaaac tggaaatcaa aggaggcgga tccggcggcg gaggccaggt ccagctggtg      360

cagagtgggg cagaggtgaa aaagccaggg gcatcagtga aagtgtcttg taaagcatca      420

ggttatacat ttactgagta catcctgcac tgggtgcgac aggcaccagg acagggactg      480

gaatggatgg ggtggttcta ccctggcaac aacaacatta agtacaacga gaagtttaaa      540

gaccgggtga ccatcacagc ggataagtct accagtacag tctatatgga gctgagctcc      600

ctgagaagcg aagacaccgc cgtctactat tgcgctcgcc acgaacaggg tccaggttac      660

tttgattatt gggggcaggg aactctggtc acagtcagct ccgcctccac caagggcgaa      720

gtggccgcat gtgagaaaga ggttgctgct ttggagaagg aggtcgctgc acttgaaaag      780

gaggtcgcag ccctggagaa actggagccc aaatcttctg acaaaactca cacatgccca      840

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc      900

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      960

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1020

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1080

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1140

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1200

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1260

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1320

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1380

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1440

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggt        1497


<210>  142
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second Polypeptide Chain of an Exemplary hDR5 mAb 2.2 x hDR5 mAb 
       2.2 Fc diabody

<400>  142

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        115                 120                 125             


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    130                 135                 140                 


Thr Glu Tyr Ile Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
145                 150                 155                 160 


Glu Trp Met Gly Trp Phe Tyr Pro Gly Asn Asn Asn Ile Lys Tyr Asn 
                165                 170                 175     


Glu Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
            180                 185                 190         


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
        195                 200                 205             


Tyr Tyr Cys Ala Arg His Glu Gln Gly Pro Gly Tyr Phe Asp Tyr Trp 
    210                 215                 220                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Lys 
225                 230                 235                 240 


Val Ala Ala Cys Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val Ala 
                245                 250                 255     


Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu 
            260                 265         


<210>  143
<211>  800
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding Second Polypeptide Chain of an Exemplary 
       hDR5 mAb 2.2 x hDR5 mAb 2.2 Fc diabody

<400>  143
gatattcaga tgacccagag tccctcattt ctgtccgcct ccgtcggtga ccgcgtgact       60

attacttgta aagcttctca ggatgtcaac accgccgtgg cttggtacca gcagaagccc      120

ggtaaagcac ctaagctgct gatctattgg gccagcactc ggcacaccgg agtcccatct      180

aggttctctg gcagtggatc agggacagac tttaccctga caattagctc cctgcagccc      240

gaggatgtgg ctacttacta ttgtcagcag cactacatca ctccttggac cttcggcggg      300

ggcacaaaac tggaaatcaa aggaggcgga tccggcggcg gaggccaggt ccagctggtg      360

cagagtgggg cagaggtgaa aaagccaggg gcatcagtga aagtgtcttg taaagcatca      420

ggttatacat ttactgagta catcctgcac tgggtgcgac aggcaccagg acagggactg      480

gaatggatgg ggtggttcta ccctggcaac aacaacatta agtacaacga gaagtttaaa      540

gaccgggtga ccatcacagc ggataagtct accagtacag tctatatgga gctgagctcc      600

ctgagaagcg aagacaccgc cgtctactat tgcgctcgcc acgaacaggg tccaggttac      660

tttgattatt gggggcaggg aactctggtc acagtcagct ccgcctccac caagggcaaa      720

gtggccgcat gtaaggagaa agttgctgct ttgaaagaga aggtcgccgc acttaaggaa      780

aaggtcgcag ccctgaaaga                                                  800


<210>  144
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First Polypeptide Chain of an Exemplary hDR5 mAb 2.2 x hDR5 mAb 
       2.2 Fc diabody L234A/L235A

<400>  144

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        115                 120                 125             


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    130                 135                 140                 


Thr Glu Tyr Ile Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
145                 150                 155                 160 


Glu Trp Met Gly Trp Phe Tyr Pro Gly Asn Asn Asn Ile Lys Tyr Asn 
                165                 170                 175     


Glu Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
            180                 185                 190         


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
        195                 200                 205             


Tyr Tyr Cys Ala Arg His Glu Gln Gly Pro Gly Tyr Phe Asp Tyr Trp 
    210                 215                 220                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Glu 
225                 230                 235                 240 


Val Ala Ala Cys Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala 
                245                 250                 255     


Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Leu Glu Pro Lys Ser 
            260                 265                 270         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly 
            


<210>  145
<211>  1497
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding First Polypeptide Chain of an Exemplary 
       hDR5 mAb 2.2 x hDR5 mAb 2.2 Fc diabody L234A/L235A

<400>  145
gatattcaga tgacccagag tccctcattt ctgtccgcct ccgtcggtga ccgcgtgact       60

attacttgta aagcttctca ggatgtcaac accgccgtgg cttggtacca gcagaagccc      120

ggtaaagcac ctaagctgct gatctattgg gccagcactc ggcacaccgg agtcccatct      180

aggttctctg gcagtggatc agggacagac tttaccctga caattagctc cctgcagccc      240

gaggatgtgg ctacttacta ttgtcagcag cactacatca ctccttggac cttcggcggg      300

ggcacaaaac tggaaatcaa aggaggcgga tccggcggcg gaggccaggt ccagctggtg      360

cagagtgggg cagaggtgaa aaagccaggg gcatcagtga aagtgtcttg taaagcatca      420

ggttatacat ttactgagta catcctgcac tgggtgcgac aggcaccagg acagggactg      480

gaatggatgg ggtggttcta ccctggcaac aacaacatta agtacaacga gaagtttaaa      540

gaccgggtga ccatcacagc ggataagtct accagtacag tctatatgga gctgagctcc      600

ctgagaagcg aagacaccgc cgtctactat tgcgctcgcc acgaacaggg tccaggttac      660

tttgattatt gggggcaggg aactctggtc acagtcagct ccgcctccac caagggcgaa      720

gtggccgcat gtgagaaaga ggttgctgct ttggagaagg aggtcgctgc acttgaaaag      780

gaggtcgcag ccctggagaa actggagccc aaatcttctg acaaaactca cacatgccca      840

ccgtgcccag cacctgaagc cgcgggggga ccgtcagtct tcctcttccc cccaaaaccc      900

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      960

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1020

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1080

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1140

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1200

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1260

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1320

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1380

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1440

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggt        1497


<210>  146
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First Polypeptide Chain of an Exemplary hDR5 mAb 2.3 x hDR5 mAb 
       2.3 Fc diabody

<400>  146

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        115                 120                 125             


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    130                 135                 140                 


Thr Glu Tyr Ile Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
145                 150                 155                 160 


Glu Trp Met Gly Trp Phe Tyr Pro Gly Asn Asn Asn Ile Lys Tyr Asn 
                165                 170                 175     


Glu Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
            180                 185                 190         


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
        195                 200                 205             


Tyr Tyr Cys Ala Arg His Glu Gln Gly Pro Gly Tyr Phe Asp Tyr Trp 
    210                 215                 220                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Glu 
225                 230                 235                 240 


Val Ala Ala Cys Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala 
                245                 250                 255     


Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Leu Glu Pro Lys Ser 
            260                 265                 270         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly 
            


<210>  147
<211>  1497
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding First Polypeptide Chain of an Exemplary 
       hDR5 mAb 2.3 x hDR5 mAb 2.3 Fc diabody

<400>  147
gatattcaga tgacccagag tccctcattt ctgtccgcct ccgtcggtga ccgcgtgact       60

attacttgtc gggcttctca ggatgtcaac accgccgtgg cttggtacca gcagaagccc      120

ggtaaagcac ctaagctgct gatctattgg gccagcactc ggcacaccgg agtcccagat      180

aggttctctg gcagtggatc agggacagac tttaccctga caattagctc cctgcagccc      240

gaggatgtgg ctacttacta ttgtcagcag cactacatca ctccttggac cttcggcggg      300

ggcacaaaac tggaaatcaa aggaggcgga tccggcggcg gaggccaggt ccagctggtg      360

cagagtgggg cagaggtgaa aaagccaggg gcatcagtga aagtgtcttg taaagcatca      420

ggttatacat ttactgagta catcctgcac tgggtgcgac aggcaccagg acagggactg      480

gaatggatgg ggtggttcta ccctggcaac aacaacatta agtacaacga gaagtttaaa      540

gaccgggtga ccatcacagc ggataagtct accagtacag tctatatgga gctgagctcc      600

ctgagaagcg aagacaccgc cgtctactat tgcgctcgcc acgaacaggg tccaggttac      660

tttgattatt gggggcaggg aactctggtc acagtcagct ccgcctccac caagggcgaa      720

gtggccgcat gtgagaaaga ggttgctgct ttggagaagg aggtcgctgc acttgaaaag      780

gaggtcgcag ccctggagaa actggagccc aaatcttctg acaaaactca cacatgccca      840

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc      900

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      960

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1020

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1080

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1140

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1200

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1260

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1320

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1380

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1440

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggt        1497


<210>  148
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second Polypeptide Chain of an Exemplary hDR5 mAb 2.3 x hDR5 mAb 
       2.3 Fc diabody

<400>  148

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        115                 120                 125             


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    130                 135                 140                 


Thr Glu Tyr Ile Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
145                 150                 155                 160 


Glu Trp Met Gly Trp Phe Tyr Pro Gly Asn Asn Asn Ile Lys Tyr Asn 
                165                 170                 175     


Glu Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
            180                 185                 190         


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
        195                 200                 205             


Tyr Tyr Cys Ala Arg His Glu Gln Gly Pro Gly Tyr Phe Asp Tyr Trp 
    210                 215                 220                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Lys 
225                 230                 235                 240 


Val Ala Ala Cys Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val Ala 
                245                 250                 255     


Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu 
            260                 265         


<210>  149
<211>  801
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding Second Polypeptide Chain of an Exemplary 
       hDR5 mAb 2.3 x hDR5 mAb 2.3 Fc diabody

<400>  149
gatattcaga tgacccagag tccctcattt ctgtccgcct ccgtcggtga ccgcgtgact       60

attacttgtc gggcttctca ggatgtcaac accgccgtgg cttggtacca gcagaagccc      120

ggtaaagcac ctaagctgct gatctattgg gccagcactc ggcacaccgg agtcccagat      180

aggttctctg gcagtggatc agggacagac tttaccctga caattagctc cctgcagccc      240

gaggatgtgg ctacttacta ttgtcagcag cactacatca ctccttggac cttcggcggg      300

ggcacaaaac tggaaatcaa aggaggcgga tccggcggcg gaggccaggt ccagctggtg      360

cagagtgggg cagaggtgaa aaagccaggg gcatcagtga aagtgtcttg taaagcatca      420

ggttatacat ttactgagta catcctgcac tgggtgcgac aggcaccagg acagggactg      480

gaatggatgg ggtggttcta ccctggcaac aacaacatta agtacaacga gaagtttaaa      540

gaccgggtga ccatcacagc ggataagtct accagtacag tctatatgga gctgagctcc      600

ctgagaagcg aagacaccgc cgtctactat tgcgctcgcc acgaacaggg tccaggttac      660

tttgattatt gggggcaggg aactctggtc acagtcagct ccgcctccac caagggcaaa      720

gtggccgcat gtaaggagaa agttgctgct ttgaaagaga aggtcgccgc acttaaggaa      780

aaggtcgcag ccctgaaaga g                                                801


<210>  150
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First Polypeptide Chain of an Exemplary hDR5 mAb 2.3 x hDR5 mAb 
       2.3 Fc diabody L234A/L235A

<400>  150

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        115                 120                 125             


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    130                 135                 140                 


Thr Glu Tyr Ile Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
145                 150                 155                 160 


Glu Trp Met Gly Trp Phe Tyr Pro Gly Asn Asn Asn Ile Lys Tyr Asn 
                165                 170                 175     


Glu Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
            180                 185                 190         


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
        195                 200                 205             


Tyr Tyr Cys Ala Arg His Glu Gln Gly Pro Gly Tyr Phe Asp Tyr Trp 
    210                 215                 220                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Glu 
225                 230                 235                 240 


Val Ala Ala Cys Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala 
                245                 250                 255     


Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Leu Glu Pro Lys Ser 
            260                 265                 270         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly 
            


<210>  151
<211>  1497
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding First Polypeptide Chain of an Exemplary 
       hDR5 mAb 2.3 x hDR5 mAb 2.3 Fc diabody L234A/L235A

<400>  151
gatattcaga tgacccagag tccctcattt ctgtccgcct ccgtcggtga ccgcgtgact       60

attacttgtc gggcttctca ggatgtcaac accgccgtgg cttggtacca gcagaagccc      120

ggtaaagcac ctaagctgct gatctattgg gccagcactc ggcacaccgg agtcccagat      180

aggttctctg gcagtggatc agggacagac tttaccctga caattagctc cctgcagccc      240

gaggatgtgg ctacttacta ttgtcagcag cactacatca ctccttggac cttcggcggg      300

ggcacaaaac tggaaatcaa aggaggcgga tccggcggcg gaggccaggt ccagctggtg      360

cagagtgggg cagaggtgaa aaagccaggg gcatcagtga aagtgtcttg taaagcatca      420

ggttatacat ttactgagta catcctgcac tgggtgcgac aggcaccagg acagggactg      480

gaatggatgg ggtggttcta ccctggcaac aacaacatta agtacaacga gaagtttaaa      540

gaccgggtga ccatcacagc ggataagtct accagtacag tctatatgga gctgagctcc      600

ctgagaagcg aagacaccgc cgtctactat tgcgctcgcc acgaacaggg tccaggttac      660

tttgattatt gggggcaggg aactctggtc acagtcagct ccgcctccac caagggcgaa      720

gtggccgcat gtgagaaaga ggttgctgct ttggagaagg aggtcgctgc acttgaaaag      780

gaggtcgcag ccctggagaa actggagccc aaatcttctg acaaaactca cacatgccca      840

ccgtgcccag cacctgaagc cgcgggggga ccgtcagtct tcctcttccc cccaaaaccc      900

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      960

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1020

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1080

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1140

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1200

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1260

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1320

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1380

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1440

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggt        1497


<210>  152
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First Polypeptide Chain of an Exemplary hDR5 mAb 2.4 x hDR5 mAb 
       2.4 Fc diabody

<400>  152

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        115                 120                 125             


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    130                 135                 140                 


Thr Glu Tyr Ile Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
145                 150                 155                 160 


Glu Trp Met Gly Trp Phe Tyr Pro Gly Asn Asn Asn Ile Lys Tyr Asn 
                165                 170                 175     


Glu Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
            180                 185                 190         


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
        195                 200                 205             


Tyr Tyr Cys Ala Arg His Glu Gln Gly Pro Gly Tyr Phe Asp Tyr Trp 
    210                 215                 220                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Glu 
225                 230                 235                 240 


Val Ala Ala Cys Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala 
                245                 250                 255     


Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Leu Glu Pro Lys Ser 
            260                 265                 270         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly 
            


<210>  153
<211>  1397
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding First Polypeptide Chain of an Exemplary 
       hDR5 mAb 2.4 x hDR5 mAb 2.4 Fc diabody

<400>  153
cttggtacca gcagaagccc ggtaaagcac ctaagctgct gatctattgg gccagcactc       60

ggcacaccgg agtcccatct aggttctctg gcagtggatc agggacagac tttaccctga      120

caattagctc cctgcagcca gaggatatcg ctacatacta ttgtcagcag cactacatca      180

ctccttggac cttcggcggg ggcacaaaac tggaaatcaa aggaggcgga tccggcggcg      240

gaggccaggt ccagctggtg cagagtgggg cagaggtgaa aaagccaggg gcatcagtga      300

aagtgtcttg taaagcatca ggttatacat ttactgagta catcctgcac tgggtgcgac      360

aggcaccagg acagggactg gaatggatgg ggtggttcta ccctggcaac aacaacatta      420

agtacaacga gaagtttaaa gaccgggtga ccatcacagc ggataagtct accagtacag      480

tctatatgga gctgagctcc ctgagaagcg aagacaccgc cgtctactat tgcgctcgcc      540

acgaacaggg tccaggttac tttgattatt gggggcaggg aactctggtc acagtcagct      600

ccgcctccac caagggcgaa gtggccgcat gtgagaaaga ggttgctgct ttggagaagg      660

aggtcgctgc acttgaaaag gaggtcgcag ccctggagaa actggagccc aaatcttctg      720

acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga ccgtcagtct      780

tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct gaggtcacat      840

gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg      900

gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac agcacgtacc      960

gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag gagtacaagt     1020

gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc aaagccaaag     1080

ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag atgaccaaga     1140

accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc gccgtggagt     1200

gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg ctggactccg     1260

acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg cagcagggga     1320

acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg cagaagagcc     1380

tctccctgtc tccgggt                                                    1397


<210>  154
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second Polypeptide Chain of an Exemplary hDR5 mAb 2.4 x hDR5 mAb 
       2.4 Fc diabody

<400>  154

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        115                 120                 125             


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    130                 135                 140                 


Thr Glu Tyr Ile Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
145                 150                 155                 160 


Glu Trp Met Gly Trp Phe Tyr Pro Gly Asn Asn Asn Ile Lys Tyr Asn 
                165                 170                 175     


Glu Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
            180                 185                 190         


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
        195                 200                 205             


Tyr Tyr Cys Ala Arg His Glu Gln Gly Pro Gly Tyr Phe Asp Tyr Trp 
    210                 215                 220                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Lys 
225                 230                 235                 240 


Val Ala Ala Cys Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val Ala 
                245                 250                 255     


Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu 
            260                 265         


<210>  155
<211>  801
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding Second Polypeptide Chain of an Exemplary 
       hDR5 mAb 2.4 x hDR5 mAb 2.4 Fc diabody

<400>  155
gatattcaga tgacccagag tccctcattt ctgtccgcct ccgtcggtga ccgcgtgact       60

attacttgtc gggcttctca ggatgtcaac accgccgtgg cttggtacca gcagaagccc      120

ggtaaagcac ctaagctgct gatctattgg gccagcactc ggcacaccgg agtcccatct      180

aggttctctg gcagtggatc agggacagac tttaccctga caattagctc cctgcagcca      240

gaggatatcg ctacatacta ttgtcagcag cactacatca ctccttggac cttcggcggg      300

ggcacaaaac tggaaatcaa aggaggcgga tccggcggcg gaggccaggt ccagctggtg      360

cagagtgggg cagaggtgaa aaagccaggg gcatcagtga aagtgtcttg taaagcatca      420

ggttatacat ttactgagta catcctgcac tgggtgcgac aggcaccagg acagggactg      480

gaatggatgg ggtggttcta ccctggcaac aacaacatta agtacaacga gaagtttaaa      540

gaccgggtga ccatcacagc ggataagtct accagtacag tctatatgga gctgagctcc      600

ctgagaagcg aagacaccgc cgtctactat tgcgctcgcc acgaacaggg tccaggttac      660

tttgattatt gggggcaggg aactctggtc acagtcagct ccgcctccac caagggcaaa      720

gtggccgcat gtaaggagaa agttgctgct ttgaaagaga aggtcgccgc acttaaggaa      780

aaggtcgcag ccctgaaaga g                                                801


<210>  156
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First Polypeptide Chain of an Exemplary hDR5 mAb 2.4 x hDR5 mAb 
       2.4 Fc diabody L234A/L235A

<400>  156

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        115                 120                 125             


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    130                 135                 140                 


Thr Glu Tyr Ile Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
145                 150                 155                 160 


Glu Trp Met Gly Trp Phe Tyr Pro Gly Asn Asn Asn Ile Lys Tyr Asn 
                165                 170                 175     


Glu Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
            180                 185                 190         


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
        195                 200                 205             


Tyr Tyr Cys Ala Arg His Glu Gln Gly Pro Gly Tyr Phe Asp Tyr Trp 
    210                 215                 220                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Glu 
225                 230                 235                 240 


Val Ala Ala Cys Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala 
                245                 250                 255     


Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Leu Glu Pro Lys Ser 
            260                 265                 270         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly 
            


<210>  157
<211>  1497
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding First Polypeptide Chain of an Exemplary 
       hDR5 mAb 2.4 x hDR5 mAb 2.4 Fc diabody L234A/L235A

<400>  157
gatattcaga tgacccagag tccctcattt ctgtccgcct ccgtcggtga ccgcgtgact       60

attacttgtc gggcttctca ggatgtcaac accgccgtgg cttggtacca gcagaagccc      120

ggtaaagcac ctaagctgct gatctattgg gccagcactc ggcacaccgg agtcccatct      180

aggttctctg gcagtggatc agggacagac tttaccctga caattagctc cctgcagcca      240

gaggatatcg ctacatacta ttgtcagcag cactacatca ctccttggac cttcggcggg      300

ggcacaaaac tggaaatcaa aggaggcgga tccggcggcg gaggccaggt ccagctggtg      360

cagagtgggg cagaggtgaa aaagccaggg gcatcagtga aagtgtcttg taaagcatca      420

ggttatacat ttactgagta catcctgcac tgggtgcgac aggcaccagg acagggactg      480

gaatggatgg ggtggttcta ccctggcaac aacaacatta agtacaacga gaagtttaaa      540

gaccgggtga ccatcacagc ggataagtct accagtacag tctatatgga gctgagctcc      600

ctgagaagcg aagacaccgc cgtctactat tgcgctcgcc acgaacaggg tccaggttac      660

tttgattatt gggggcaggg aactctggtc acagtcagct ccgcctccac caagggcgaa      720

gtggccgcat gtgagaaaga ggttgctgct ttggagaagg aggtcgctgc acttgaaaag      780

gaggtcgcag ccctggagaa actggagccc aaatcttctg acaaaactca cacatgccca      840

ccgtgcccag cacctgaagc cgcgggggga ccgtcagtct tcctcttccc cccaaaaccc      900

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      960

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1020

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1080

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1140

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1200

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1260

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1320

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1380

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1440

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggt        1497


<210>  158
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First Polypeptide Chain of an Exemplary hDR5 mAb 2.5 x hDR5 mAb 
       2.5 Fc diabody

<400>  158

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        115                 120                 125             


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    130                 135                 140                 


Thr Glu Tyr Ile Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
145                 150                 155                 160 


Glu Trp Met Gly Trp Phe Tyr Pro Gly Asn Asn Asn Ile Lys Tyr Asn 
                165                 170                 175     


Glu Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
            180                 185                 190         


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
        195                 200                 205             


Tyr Tyr Cys Ala Arg His Glu Gln Gly Pro Gly Tyr Phe Asp Tyr Trp 
    210                 215                 220                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Glu 
225                 230                 235                 240 


Val Ala Ala Cys Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala 
                245                 250                 255     


Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Leu Glu Pro Lys Ser 
            260                 265                 270         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly 
            


<210>  159
<211>  1497
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding First Polypeptide Chain of an Exemplary 
       hDR5 mAb 2.5 x hDR5 mAb 2.5 Fc diabody

<400>  159
gatattcaga tgacccagag tccctcattt ctgtccgcct ccgtcggtga ccgcgtgact       60

attacttgtc gggcttctca ggatgtcaac accgccgtgg cttggtacca gcagaagccc      120

ggtaaagcac ctaagctgct gatctattgg gccagcactc ggcacaccgg agtcccagat      180

aggttctctg gcagtggatc agggacagac tttaccctga caattagctc cctgcagccc      240

gaggatatcg ctacttacta ttgtcagcag cactacatca ctccttggac cttcggcggg      300

ggcacaaaac tggaaatcaa aggaggcgga tccggcggcg gaggccaggt ccagctggtg      360

cagagtgggg cagaggtgaa aaagccaggg gcatcagtga aagtgtcttg taaagcatca      420

ggttatacat ttactgagta catcctgcac tgggtgcgac aggcaccagg acagggactg      480

gaatggatgg ggtggttcta ccctggcaac aacaacatta agtacaacga gaagtttaaa      540

gaccgggtga ccatcacagc ggataagtct accagtacag tctatatgga gctgagctcc      600

ctgagaagcg aagacaccgc cgtctactat tgcgctcgcc acgaacaggg tccaggttac      660

tttgattatt gggggcaggg aactctggtc acagtcagct ccgcctccac caagggcgaa      720

gtggccgcat gtgagaaaga ggttgctgct ttggagaagg aggtcgctgc acttgaaaag      780

gaggtcgcag ccctggagaa actggagccc aaatcttctg acaaaactca cacatgccca      840

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc      900

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      960

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1020

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1080

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1140

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1200

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1260

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1320

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1380

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1440

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggt        1497


<210>  160
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second Polypeptide Chain of an Exemplary hDR5 mAb 2.5 x hDR5 mAb 
       2.5 Fc diabody

<400>  160

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        115                 120                 125             


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    130                 135                 140                 


Thr Glu Tyr Ile Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
145                 150                 155                 160 


Glu Trp Met Gly Trp Phe Tyr Pro Gly Asn Asn Asn Ile Lys Tyr Asn 
                165                 170                 175     


Glu Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
            180                 185                 190         


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
        195                 200                 205             


Tyr Tyr Cys Ala Arg His Glu Gln Gly Pro Gly Tyr Phe Asp Tyr Trp 
    210                 215                 220                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Lys 
225                 230                 235                 240 


Val Ala Ala Cys Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val Ala 
                245                 250                 255     


Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu 
            260                 265         


<210>  161
<211>  801
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding Second Polypeptide Chain of an Exemplary 
       hDR5 mAb 2.5 x hDR5 mAb 2.5 Fc diabody

<400>  161
gatattcaga tgacccagag tccctcattt ctgtccgcct ccgtcggtga ccgcgtgact       60

attacttgtc gggcttctca ggatgtcaac accgccgtgg cttggtacca gcagaagccc      120

ggtaaagcac ctaagctgct gatctattgg gccagcactc ggcacaccgg agtcccagat      180

aggttctctg gcagtggatc agggacagac tttaccctga caattagctc cctgcagccc      240

gaggatatcg ctacttacta ttgtcagcag cactacatca ctccttggac cttcggcggg      300

ggcacaaaac tggaaatcaa aggaggcgga tccggcggcg gaggccaggt ccagctggtg      360

cagagtgggg cagaggtgaa aaagccaggg gcatcagtga aagtgtcttg taaagcatca      420

ggttatacat ttactgagta catcctgcac tgggtgcgac aggcaccagg acagggactg      480

gaatggatgg ggtggttcta ccctggcaac aacaacatta agtacaacga gaagtttaaa      540

gaccgggtga ccatcacagc ggataagtct accagtacag tctatatgga gctgagctcc      600

ctgagaagcg aagacaccgc cgtctactat tgcgctcgcc acgaacaggg tccaggttac      660

tttgattatt gggggcaggg aactctggtc acagtcagct ccgcctccac caagggcaaa      720

gtggccgcat gtaaggagaa agttgctgct ttgaaagaga aggtcgccgc acttaaggaa      780

aaggtcgcag ccctgaaaga g                                                801


<210>  162
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First Polypeptide Chain of an Exemplary hDR5 mAb 2.5 x hDR5 mAb 
       2.5 Fc diabody L234A/L235A

<400>  162

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
        115                 120                 125             


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    130                 135                 140                 


Thr Glu Tyr Ile Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
145                 150                 155                 160 


Glu Trp Met Gly Trp Phe Tyr Pro Gly Asn Asn Asn Ile Lys Tyr Asn 
                165                 170                 175     


Glu Lys Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
            180                 185                 190         


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
        195                 200                 205             


Tyr Tyr Cys Ala Arg His Glu Gln Gly Pro Gly Tyr Phe Asp Tyr Trp 
    210                 215                 220                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Glu 
225                 230                 235                 240 


Val Ala Ala Cys Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val Ala 
                245                 250                 255     


Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Leu Glu Pro Lys Ser 
            260                 265                 270         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly 
            


<210>  163
<211>  1497
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding First Polypeptide Chain of an Exemplary 
       hDR5 mAb 2.5 x hDR5 mAb 2.5 Fc diabody L234A/L235A

<400>  163
gatattcaga tgacccagag tccctcattt ctgtccgcct ccgtcggtga ccgcgtgact       60

attacttgtc gggcttctca ggatgtcaac accgccgtgg cttggtacca gcagaagccc      120

ggtaaagcac ctaagctgct gatctattgg gccagcactc ggcacaccgg agtcccagat      180

aggttctctg gcagtggatc agggacagac tttaccctga caattagctc cctgcagccc      240

gaggatatcg ctacttacta ttgtcagcag cactacatca ctccttggac cttcggcggg      300

ggcacaaaac tggaaatcaa aggaggcgga tccggcggcg gaggccaggt ccagctggtg      360

cagagtgggg cagaggtgaa aaagccaggg gcatcagtga aagtgtcttg taaagcatca      420

ggttatacat ttactgagta catcctgcac tgggtgcgac aggcaccagg acagggactg      480

gaatggatgg ggtggttcta ccctggcaac aacaacatta agtacaacga gaagtttaaa      540

gaccgggtga ccatcacagc ggataagtct accagtacag tctatatgga gctgagctcc      600

ctgagaagcg aagacaccgc cgtctactat tgcgctcgcc acgaacaggg tccaggttac      660

tttgattatt gggggcaggg aactctggtc acagtcagct ccgcctccac caagggcgaa      720

gtggccgcat gtgagaaaga ggttgctgct ttggagaagg aggtcgctgc acttgaaaag      780

gaggtcgcag ccctggagaa actggagccc aaatcttctg acaaaactca cacatgccca      840

ccgtgcccag cacctgaagc cgcgggggga ccgtcagtct tcctcttccc cccaaaaccc      900

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      960

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1020

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1080

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1140

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1200

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1260

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1320

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1380

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1440

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggt        1497


<210>  164
<211>  216
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(216)
<223>  Human Wild-Type IgG2 CH2-CH3 Domain

<400>  164

Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            20                  25                  30          


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        35                  40                  45              


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    50                  55                  60                  


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
65                  70                  75                  80  


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                85                  90                  95      


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
            100                 105                 110         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        115                 120                 125             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    130                 135                 140                 


Asp Ile Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
145                 150                 155                 160 


Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                165                 170                 175     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            180                 185                 190         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        195                 200                 205             


Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215     


<210>  165
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-DR5 mAb 2 Light Chain Variable Region Variant 3, 
       4, 5 CDRL1

<400>  165

Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala 
1               5                   10      


<210>  166
<211>  107
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  OKT3 Anti-CD3 Antibody Light Chain Variable Domain

<400>  166

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Arg 
            100                 105         


<210>  167
<211>  192
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(192)
<223>  OKT3 Anti-CD3 Antibody Heavy Chain Variable Domain

<400>  167

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr 
        115                 120                 125             


Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp 
145                 150                 155                 160 


Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser 
            180                 185                 190         


<210>  168
<211>  217
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(217)
<223>  Human Wild-Type IgG3 CH2-CH3 Domain

<400>  168

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


