                         SEQUENCE LISTING

<110>  Temasek Life Sciences Laboratory Limited
 
<120>  Enterovirus 71 Animal Model

<130>  2577-243PCT

<150>  US 62/114,880
<151>  2015-02-11

<150>  US 62/108,828
<151>  2015-01-28

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  7438
<212>  DNA
<213>  Enterovirus 71:TLLm

<400>  1
ttcaaacagc ctgtgggttg cacccactca cagggcccac gtggcgctag cactctggtt       60

ctacggaacc tttgtgcgcc tgttttacgc cccttcccca atttgcaact tagaagcaat      120

acacaacact gatcaacagc gggcatggcg caccagctat gtcttgatca agcacttctg      180

tttccccgga ccgactatca atagactgct cacgcggttg aaggagaaag cgtccgttat      240

ccggctaact acttcgaaaa acctagtaac accattgaag ctgcagagtg tttcgctcgg      300

cacttccccc gtgtagatca ggtcgatgag tcactgcaat ccccacgggt gaccgtggca      360

gtggctgcgt tggcggcctg cctatggggc aacccatagg acgctctaat gcggacatgg      420

tgcgaagagt ctattgagct agttagtagt cctccggccc ctgaatgcgg ctaatcctaa      480

ctgcggagca catgccttca acccagaggg tagtgtgtcg taatgggcaa ctctgcagcg      540

gaaccgacta ctttgggtgt ccgtgtttcc ttttattctt atattggctg cttatggtga      600

caattacaga attgttacca tatagctatt ggattggcca tccggtgtgc aatagagcta      660

ttatatacct ttttttttgg ctttgtacca ctaaccttaa aatctataat caccctcgac      720

tttatattaa ccctcaacac agtcaagcat gggctcacag gtgtccactc agcgatccgg      780

ctcccacgag aactccaatt cagctacagg aggctccacc attaattaca ctaccatcaa      840

ctattacaaa gactcctatg ctgcgacagc gggcaaacag agcctcaaac aagaccctga      900

taagtttgct aaccctgtca aggacatttt cactgaaatg gctgcgccac tgaagtctcc      960

atccgctgaa gcttgtggtt acagtgatcg cgtggcacaa ctcaccattg gaaactccac     1020

cattactaca caggaggcgg caaacatcat agttggttac ggtgagtggc cctcatactg     1080

ctctgatgac gacgctacag cggtggacaa accaacgcgc ccagatgttt cagtgaatag     1140

gttttataca ctggacacta aactgtggga aaagtcatcc aaggggtggt attggaagtt     1200

tcctgatgtg ttgactgaga ccggagtctt tggccagaac gcacagtttc actatttgta     1260

taggtcaggg ttttgcattc atgtgcaatg taacgctagc aagttccatc aaggagcgct     1320

gttagtcgcc atacttccag agtatgttat agggacaata gcaggcggta caggaacaga     1380

ggacacccac cctccttaca tacaaacaca acctggcgcc gacggtttcg agctgcagca     1440

cccgtacgtg ctcgatgctg ggattcctat atcacaattg acagtgtgtc cccatcaatg     1500

gattaacctg cggaccaata actgtgccac aataatagtg ccatatatga acacactgcc     1560

tttcgactct gccctgaacc attgcaattt tgggctgttg gtagtaccca ttagcccatt     1620

agattttgac caaggggcaa ctccggttat ccctattaca atcactctag ctccaatgtg     1680

ctctgagttt gcaggtctca gacaggcagt cactcaaggc tttcccactg agccaaaacc     1740

aggaacgaat caattcttga ccaccgatga cggcgtctca gcacccattc taccaaattt     1800

ccatcccact ccatgtattc acatacccgg tgaagtcaga aacctgcttg agttgtgtca     1860

agtggagact attcttgagg ttaacaacgt acccaccaat gctaccagtc tgatggaaag     1920

gctacgattc ccggtgtccg cgcaagcggg gaaaggtgaa ttgtgtgccg tgtttagggc     1980

cgaccctgga agagacggtc catggcaatc aacaatgctg ggccagttgt gtggatatta     2040

cacccagtgg tcagggtcac tggaggtcac ttttatgttt accgggtctt tcatggccac     2100

aggtaaaatg ctcatagctt atacacctcc tggcggcccc ttacccaaag atcgggccac     2160

agcaatgctg ggcacacatg ttatctggga ttttgggcta caatcatctg tcacccttgt     2220

aataccatgg attagtaata cccactacag ggcgcatgcc cgggatggag tgtttgacta     2280

ctataccaca ggactggtca gtatctggta tcaaacaaac tacgtagttc caattggggc     2340

acccaacaca gcttatataa tagcactagc ggcagcccag aagaatttca ccatgaaact     2400

gtgcaaagac accagtcaca tattacagac agcctccatt cagggagata gggtggcaga     2460

tgcgatcgag agctctatag gagatagtgt gagtagggca cttacccagg ccctgccagc     2520

acccacaggt caaaacacac aggtgagcag tcatcgacta gacactggcg aagttccagc     2580

gctccaagct gctgaaattg gggcatcgtc aaatactagt gatgagagta tgattgagac     2640

acgatgcgtt cttaactcac atagtacagc agagaccacc ttggacagtt tcttcagtag     2700

ggcaggtttg gtaggagaga tagatttccc tcttgagggt accaccaatc cagatggtta     2760

tgccaactgg gacatagaca taactggtta cgcacaaatg cgcaggaaag tggagctgtt     2820

cacctacatg cgctttgatg cggaattcac ttttgttgcg tgcactccta ctggtgcggt     2880

tgttccacaa ttactccagt atatgtttgt tccccctggt gctcccaaac cagagtctag     2940

agattcattt gcttggcaga cagccacaaa cccctcagtc tttgtcaagt tgactgatcc     3000

cccggcacag gtctcagttc cgttcatgtc acccgcgagc gcttaccagt ggttttacga     3060

cgggtacccc acgtttggag aacacaaaca ggagaaagac ctcgagtatg gagcgtgtcc     3120

taataatatg atgggcactt tctcggtgcg aaccgtgggg tcattaaagt ccaagtaccc     3180

cttggttgtc agaatatata tgagaatgaa gcatgtcagg gcgtggatac ctcgcccgat     3240

gcgcaaccaa aactatttgt tcaaagccaa cccaaactat gccggtaact ccattaagcc     3300

gaccggcact agtcgtactg ccattactac ccttggaaag ttcggccagc agtctggggc     3360

catctacgtg ggcaacttca gagtggttaa tcgtcacctc gctactcata atgactgggc     3420

gaacctcgtc tgggaagaca gctcccgcga cctattagtg tcgtctacca ccgctcaggg     3480

ctgtgataca attgcacgtt gtgactgtca aacaggagtg tactattgta attccaagag     3540

aaagcactat ccagtcagct tttctaaacc cagcctcata tatgtggaag ctagcgagta     3600

ttaccctgct agataccaat cgcacctgat gcttgcagtg ggccactctg agcccggcga     3660

ctgcggaggc atcttgaggt gtcaacatgg tgtagttggt atagtgtcca cgggtggcaa     3720

cgagctcgtt ggatttgctg atgtgaggga tctcttgtgg ttagatgaag aggccatgga     3780

gcaaggtgtg tccgactaca ttaaggggct cggtgatgcg tttggaacag gcttcactga     3840

cgctgtatcc agggaagttg aagcccttag gaaccacctt ataggatctg atggagcagt     3900

tgagaaaatc ctaaagaacc ttattaagct gatttcagcg ttagtaattg tgatcaggag     3960

cgattatgat atggtcaccc tcacagcaac tttagccctg attggttgtc atggaagtcc     4020

ttgggcttgg attaaagcca agacagcatc cattttaggt atccccatcg cccagaagca     4080

gagtgcttct tggctaaaga aatttaatga tatggcgagt gctgccaagg gtttagaatg     4140

gatatctaat aaaattagca agttcattga ctggctcagg gagaaaattg ttccagcagc     4200

taaggagaaa gcagaatttt taaccaattt gaagcaattg ccactattag agaaccagat     4260

cacaaattta gagcagtccg ctgcctcaca agaggacctt gaagctatgt ttgggaatgt     4320

gtcatacctc gcccatttct gtcgcaagtt ccaaccatta tacgccgcgg aagctaagcg     4380

agtctatgtt ctagagaaga gaatgaataa ctacatgcag ttcaagagca aacaccgtat     4440

tgaacctgta tgtctcatca ttagaggctc accaggcact ggaaagtccc ttgcgaccgg     4500

tatcattgct cgggccatag cagacaagta tcactctagt gtgtactcac ttccaccaga     4560

ccctgaccat tttgacgggt acaaacagca agtggttaca gttatggatg atctgtgtca     4620

raatcctgac ggcaaagaca tgtcattatt ttgccagatg gtgtctaccg tggattttat     4680

cccaccaatg gcttctctcg aagaaaaggg agtttctttc acatctaaat ttgttatcgc     4740

atccaccaac gctagcaaca ttatagtgcc tacagtgtca gactctgacg ccattcgtcg     4800

caggttttac atggattgcg acattgaggt gacagactca tacaaaacag atttgggtag     4860

actagacgct ggacgggctg ctaagctatg ctctgagaac aacaccgcaa acttcaaacg     4920

atgcagccca ctagtgtgtg ggaaagctat tcaacttaga gacaggaagt ctaaggtcag     4980

gtacagcgtg gacacagtgg tctctgaact tattagagaa tataatagca gatccgctat     5040

tggtaataca attgaagcac tattccaagg tccacccaag ttcaggccaa ttagaatcag     5100

tcttgaggag aagccagccc cagacgctat tggcgatctc ctcgctagtg tagatagcga     5160

ggaagtgcgc caatactgta gggagcaagg ctggatcatc cctgaaactc ccaccaatgt     5220

tgaacgacac cttaatagag cagtgctagt catgcaatcc atcgctactg tggtggcagt     5280

cgtctcactg gtgtacgtta tttacaagct ctttgcgggg tttcaaggtg cgtactctgg     5340

agctcccaag caaatgccca agaaacctgt cctccgtacg gcaacagtgc agggtccgag     5400

tcttgacttt gctctatcct tactgagaag gaacatcagg caagtccaaa cagatcaagg     5460

gcattttacc atgttaggtg tcagagatcg cttagccgtt cttccacggc actcacagcc     5520

cgggaagact atttgggtgg agcacaaact tgtgaacgtc cttgacgcag ttgagctggt     5580

ggatgagcag ggcgttaatt tggaactcac attggtgaca ctagatacta atgaaaaatt     5640

tagagatatc accaagttca ttccagagac cattagcggc gctagtgatg caactttagt     5700

gatcaacaca gaacatatgc catcaatgtt tgtcccagtg ggggacgtcg tgcagtacgg     5760

gttcttgaac cttagtggaa agccaactca taggaccatg atgtacaatt tccctacaaa     5820

agcaggacag tgtggaggtg tggtcacatc agtcggtaag attgttggca ttcacattgg     5880

cggcaacggg cgccaagggt tctgtgctgg tttgaagagg agttacttcg caagtgtgca     5940

gggtgagatc caatgggtga agcctaacaa ggaaactggt agactgaaca tcaatggtcc     6000

aactcgcact aagctggagc ctagtgtgtt tcatgatgtg tttgaaggta ataaggaacc     6060

agcagtttta acaagtaaag accctagatt ggaggtcgac tttgaacaag ccctgttttc     6120

caagtatgtg ggcaatgttt tacacgagcc cgatgaatac gtgattcaag ctgccctcca     6180

ctacgcgaat caacttaaac aattggacat agacactagc aagatgagca tggaggaagc     6240

gtgctatggc actgaaaacc tggaagcaat agacctctgc actagtgccg ggtacccata     6300

cagcgccctt ggtatcaaga aaagagacat tcttgacccc acaaccaggg atgtgtccaa     6360

gatgaaattc tatatggata aatacgggct agacctgcca tactctacct atgtgaagga     6420

tgagcttagg tccctggata aaatcaagaa aggaaaatca cgcttgatag aggctagtag     6480

cttgaatgac tctgtctacc ttagaatgac ttttgggcac ctttacgagg tgtttcatgc     6540

caaccctggc actgtgactg gctcagcagt gggttgcaac ccggacgtgt tttggagcaa     6600

actaccgatt ctgctgcctg ggtcactctt tgcctttgac tactcaggat acgatgctag     6660

tctcagcccg gtatggttca gggctctaga agttgtgtta cgggagattg ggtattcaga     6720

ggaggccgtg tccctaatag aagggatcaa ccacacccac catgtgtacc ggaacaaaac     6780

atactgtgta cttggtggaa tgccctcggg atgttctggt acttccatct ttaatacaat     6840

gatcaacaac atcatcatta gaaccctttt gatcaaaacc tttaagggaa tagacctgga     6900

tgagttgaac atggtggcct atggggacga tgtgctggct agttacccct ttcccattga     6960

ttgccttgag ttggctaaga ctggcaaaga gtatggtttg accatgacac ctgcagacaa     7020

atcaccctgt ttcaatgaag taacatggga aaatgctacc ttcctgaaga gaggattctt     7080

gccagaccac caatttccat tcttaattca ccctacgatg cccatgagtg agatccgtga     7140

gtccattcga tggactaaag acgcgcgcaa cacccaagat cacgtgcgct ccctgtgtct     7200

gttggcatgg cacaatggta aggatgaata tgagaagttt gtgagtgcaa ttagatcagt     7260

tccagttgga aaagcgttgg ccattcctaa tttcgagaac ctgagaagaa attggctcga     7320

attgttttaa tattacagct taaagctgaa ccccactaga aatctggtcg cgttaatgac     7380

tagtgggggt aaatttgtta taaccagaat agcaaaaaaa aaaaaaaaaa aaaaaaaa       7438


<210>  2
<211>  7421
<212>  DNA
<213>  Enterovirus 71:TLLmv

<400>  2
ttcaaacagc ctgtgggttg cacccactca cagggcccac gtggcgctag cactctggtt       60

ctacggaacc tttgtgcgcc tgttttacgc cccttcccca atttgcaact tagaagcaat      120

acacaacact gatcaacagg cggcatggcg caccagctat gtcttgatca agcacttctg      180

tttccccgga ccgagtatca atagactgct cacgcggttg aaggagaaag cgtccgttat      240

ccggctaact acttcgaaaa acctagtaac accattgaag ctgcagagtg tttcgctcgg      300

cacttccccc gtgtagatca ggtcgatgag tcactgcaat ccccacgggt gaccgtggca      360

gtggctgcgt tggcggcctg cctatggggc aacccatagg acgctctaat gcggacatgg      420

tgcgaagagt ctattgagct agttagtagt cctccggccc ctgaatgcgg ctaatcctaa      480

ctgcggagca catgccttca acccagaggg tagtgtgtcg taatgggcaa ctctgcagcg      540

gaaccgacta ctttgggtgt ccgtgtttcc ttttattctt atattggctg cttatggtga      600

caattacaga attgttacca tatagctatt ggattggcca tccggtgtgc aatagagcta      660

ttatatacct atttttcttt tggctttgta tcactaacct taaaatctat aatcaccctc      720

gactttatag catgggctca caggtgtcca ctcagcgatc cggctcccac gagaactcca      780

attcagctac aggaggctcc accattaatt acactaccat caactattac aaagactcct      840

atgctgcgac agcgggcaaa cagagtctca aacaagaccc tgataagttt gctaaccctg      900

tcaaggacat tttcactgaa atggctgcgc cactgaagtc tccatccgct gaagcttgtg      960

gttacagtga tcgcgtggca caactcacca ttggaaactc caccattact acacaggagg     1020

cggcaaacat catagttggt tacggtgagt ggccctcata ctgctctgat gacgacgcta     1080

cagcggtgga caaaccaacg cgcccagatg tttcagtgaa taggttttat acactggaca     1140

ctaaactgtg ggaaaagtca tccaaggggt ggtattggaa gtttcctgat gtgttgactg     1200

agaccggagt ctttggccag aatgcacagt ttcactattt gtataggtca gggttttgca     1260

ttcatgtgca atgtaacgct agcaagttcc atcaaggagc gctgttagtc gccatacttc     1320

cagagtatgt tatagggaca atagcaggcg gtacaggaac agaggacacc caccctcctt     1380

acatacaaac acaacctggc gccgacggtt tcccgctgca gcacccgtac gtgctcgatg     1440

ctgggattcc tatatcacaa ttgacagtgt gtccccatca atggattaac ctgcggacca     1500

ataactgtgc cacaataata gtgccatata tgaacacact gcctttcgac tctgccctga     1560

accattgcaa ttttgggctg ttggtagtac ccattagccc attagatttt gaccaagggg     1620

caactccggt tatccctatt acaatcactc tagctccaat gtgctctgag tttgcaggtc     1680

tcagacaggc agtcactcaa ggctttccca ctgagccaaa accaggaacg aatcaattct     1740

tgaccaccga tgacggcgtc tcagcaccca ttctaccaaa tttccatccc actccatgta     1800

ttcacatacc cggtgaagtc agaaacctgc ttgagttgtg tcaagtggag actattcttg     1860

aggttaacaa tgtacccacc aatcctacca gtctgatgga aaggctacga ttcccggtgt     1920

ccgcgcaagc ggggaaaggt gaattgtgtg ccgtgtttag ggccgaccct ggaagagacg     1980

gtccatggca atcaacaatg ctgggccagt tgtgtggata ttacacccag tggtcagggt     2040

cactggaggt cacttttatg tttaccgggt ctttcatggc cacaggtaaa atgctcatag     2100

cttatacacc tcctggcggc cccttaccca aagatcgggc cacagcaatg ctgggcacac     2160

atgttatctg ggattttggg ctacaatcat ctgtcaccct tgtaatacca tggattagta     2220

atacccacta cagggcgcat gcccgggatg gagtgtttga ctactatacc gcaggactgg     2280

tcagtatctg gtatcaaaca aactacgtag ttccaattgg ggcacccaac acagcttata     2340

taatagcact agcggcagcc cagaagaatt tcaccatgaa actgtgcaaa gacaccagtc     2400

acatgttaca gacagcctcc attcagggag atagggtggc agatgcgatc gagagctcta     2460

taggagatag tgtgagtagg gcacttaccc aggccctgcc agcacccaca ggtaaaaaca     2520

cacaggtgag cagtcatcga ctagacactg gcgaagttcc agcgctccaa gctgctgaaa     2580

ttggggcatc gtcaaatact agtgatgaga gtatgattga gacacgatgc gttcttaact     2640

cacatagtac agcagagacc accttggaca gtttcttcag tagggcaggt ttggtaggag     2700

aggtagaatt ccctcttgag ggtaccacca atccaggtgg ttatgccaac tgggacatag     2760

acataactgg ttacgcacaa atgcgcagga aagtggagct gttcacctac atgcgctttg     2820

atgcggaatt cacttttgtt gcgtgcactc ctactggtgc ggttgttcca caattactcc     2880

agtatatgtt tgttcccccc ggtgctccca aaccagagtc tagagattca tttgcttggc     2940

agacagccac aaacccctca gtctttgtca agttgactga tcccccggca caggtctcag     3000

ttccgttcat gtcacccgcg agcgcttacc agtggtttta cgacgggtac cccacgtttg     3060

gagaacacaa acaggagaaa gacctcgagt atggagcgtg tcctaataat atgatgggca     3120

ctttctcggt gcgaaccgtg gggtcattaa agtccaagca ccccttgatt gtcagaatat     3180

atatgagaat gaagcatgtc agggcgtgga tacctcgccc gatgcgcaac caaaactatt     3240

tgttcaaagc caacccaaac tatgccggta actccattaa gccgaccggc actagtcgta     3300

cttccattac cacccttgga aagttcggcc agcagtctgg ggccatctac gtgggcaact     3360

tcagagtggt taatcgtcac ctcgctactc ataacgactg ggcgaacctc gtctgggaag     3420

acagctcccg cgacctatta gtgtcgtcta ccaccgctca gggctgtgat acaattgcac     3480

gttgtgactg tcaaacagga gtgtactatt gtaattccaa gagaaagcac tatccagtca     3540

gcttttctaa acccagcctc atatatgtgg aagctagcga gtattaccct gctagatacc     3600

aatcgcacct gatgcttgca gtgggccact ctgagcccgg cgactgcgga ggcatcttga     3660

ggtgtcaaca tggtgtagtt ggtatagtgt ccacgggtgg caacgagctc gttggatttg     3720

ctgatgtgag ggatctcttg tggttagatg aagaggccat ggagcaaggt gtgtccgact     3780

acattaaggg gctcggtgat gcgtttggaa caggcttcac tgacgctgta tccagggaag     3840

ttgaagccct taggaaccac cttataggat ctgatggagc agttgagaaa atcctaaaga     3900

accttattaa gctgatttca gcgttagtaa ttgtgatcag gagcgattat gatatggtca     3960

ccctcacagc aactttagcc ctgattggtt gtcatggaag tccttgggct tggattaaag     4020

ccaagacagc atccatttta ggtatcccca tcgcccagaa gcagagtgct tcttggctaa     4080

agaaatttaa tgatatggcg agtgctgcca agggtttaga atggatatct aataaaatta     4140

gcaagttcat tgactggctc agggagaaaa ttgttccagc agctaaggag aaagcagaat     4200

ttttaaccaa tttgaagcaa ttgccactat tagagaacca gatcacaaat ttagagcagt     4260

ccgctgcctc acaagaggac cttgaagcta tgtttgggaa tgtgtcatac ctcgcccatt     4320

tctgtcgcaa gttccaacca ttatacgccg cggaagctaa gcgagtctat gttctagaga     4380

agagaatgaa taactacatg cagttcaaga gcaaacaccg tattgaacct gtatgtctca     4440

tcattagagg ctcaccaggc actggaaagt cccttgcgac cggtatcatt gctcgggcca     4500

tagcagacaa gtatcactct agtgtgtact cacttccacc agaccctgac cattttgacg     4560

ggtacaaaca gcaagtggtt acagttatgg atgatctgtg tcagaatcct gacggcaaag     4620

acatgtcatt attttgccag atggtgtcta ccgtggattt tatcccacca atggcttctc     4680

tcgaagaaaa gggagtttct ttcacatcta aatttgttat cgcatccacc aacgctagca     4740

acattatagt gcctacagtg tcagactctg acgccattcg tcgcaggttt tacatggatt     4800

gcgacattga ggtgacagac tcatacaaaa cagatttggg tagactagac gctggacggg     4860

ctgctaagct atgctctgag aacaacaccg caaacttcaa acgatgcagc ccactagtgt     4920

gtgggaaagc tattcaactt agagacagga agtctaaggt caggtacagc gtggacacag     4980

tggtctctga acttattaga gaatataata gcagatccgc tattggtaat acaattgaag     5040

cactattcca aggtccaccc aagttcaggc caattagaat cagtcttgag gagaagccag     5100

tcccagacgc tattggcgat ctcctcgcta gtgtagatag cgaggaagtg cgccaatact     5160

gtagggagca aggctggatc atccctgaaa ctcccaccaa tgttgaacga caccttaata     5220

gagcagtgct agtcatgcaa tccatcgcta ctgtggtggc agtcgtctca ctggtgtacg     5280

ttatttacaa gctctttgcg gggtttcaag gtgcgtactc tggagctccc aagcaaatgc     5340

ccaagaaacc tgtcctccgt acggcaacag tgcagggtcc gagtcttgac tttgctctat     5400

ccttactgag aaggaacatc aggcaagtcc aaacagatca agggcatttt accatgttag     5460

gtgtcagaga tcgcttagcc gttcttccac ggcactcaca gcccgggaag actatttggg     5520

tggagcacaa acttgtgaac gtccttgacg cagttgagct ggtggatgag cagggcgtta     5580

atttggaact cacattggtg acactagata ctaatgaaaa atttagagat atcaccaagt     5640

tcattccaga gaccattagc ggcgctagtg atgcaacttt agtgatcaac acagaacata     5700

tgccatcaat gtttgtccca gtgggggacg tcgtgcagta cgggttcttg aaccttagtg     5760

gaaagccaac tcataggacc atgatgtaca atttccctac aaaagcagga cagtgtggag     5820

gtgtggtcac atcagtcggt aagattgttg gcattcacat tggcggcaac gggcgccaag     5880

ggttctgtgc tggtttgaag aggagttact tcgcaagtgt gcagggtgag atccaatggg     5940

tgaagcctaa caaggaaact ggtagactga acatcaatgg tccaactcgc actaagctgg     6000

agcctagtgt gtttcatgat gtgtttgaag gtaataagga accagcagtt ttatcaagca     6060

aagaccctag attggaggtc gactttgaac aagccctgtt ttccaagtat gtgggcaatg     6120

ctttacacga gcccgatgaa tacgtgattc aagctgccct ccactacgcg aatcaactta     6180

aacaattgga catagacact agcaagatga gcatggagga agcgtgctat ggcactgaaa     6240

acctggaagc aatagacctc tgcactagtg ccgggtaccc atacagcgcc cttggtatca     6300

agaaaagaga cattcttgac cccacaacca gggatgtgtc caagatgaaa ttctatatgg     6360

ataaatacgg gctagacctg ccatactgta cctatgtgaa ggatgagctt aggtccctgg     6420

ataaaatcaa gaaaggaaaa tcacgcttga tagaggctag tagcttgaat gactctgtct     6480

accttagaat gacttttggg cacctttacg aggtgtttca tgccaaccct ggcactgtga     6540

ctggctcagc agtgggttgc aacccggacg tgtttgggag caaactaccg attctgctgc     6600

ctgggtcact ctttgccttt gactactcag gatacgatgc tagtctcagc ccggtatggt     6660

tcagggctct agaagttgtg ttacgggaga ttgggtattc agaggaggcc gtgtccctaa     6720

tagaagggat caaccacacc caccatgtgt accggaacaa aacatactgt gtacttggtg     6780

gaatgccctc gggatgttct ggtacttcca tctttaatac aatgatcaac aacatcatca     6840

ttagaaccct tttgatcaaa acctttaagg gaatagacct ggatgagttg aacatggtgg     6900

cctatgggga cgatgtgctg gctagttacc cctttcccat tgattgcctt gagttggcta     6960

agactggcaa agagtatggt ttgaccatga cacctgcaga caaatcaccc tgtttcaatg     7020

aagtaacatg ggaaaatgct accttcctga agagaggatt cttgccagac caccaatttc     7080

cattcttaat tcaccctacg atgcccatga gtgagatccg tgagtccatt cgatggacta     7140

aagacgcgcg caacacccaa gatcacgtgc gctccctgtg tctgttggca tggcacaatg     7200

gtaaggatga atatgagaag tttgtgagtg caattagatc agttccagtt ggaaaagcgt     7260

tggccattcc taatttcgag aacctgagaa gaaattggct cgaattgttt taatattaca     7320

gcttaaagct gaaccccact agaaatctgg tcgcgttaat gactagtggg ggtaaatttg     7380

ttataaccag aatagcaaaa aaaaaaaaaa aaaaaaaaaa a                         7421


<210>  3
<211>  7437
<212>  DNA
<213>  Enterovirus 71:BS

<400>  3
ttcaaacagc ctgtgggttg cacccactca cagggcccac gtggcgctag cactctggtt       60

ctacggaacc tttgtgcgcc tgttttacgc cccttcccca atttgcaact tagaagcaat      120

acacaacact gatcaacagc aggcatggcg caccagctat gtcttgatca agcacttctg      180

tttccccgga ccgagtatca atagactgtt cacgcggttg aaggagaaag cgtccgttat      240

ccggctaact acttcgagaa acctagtaac accattgaag ctgcagagtg tttcgctcgg      300

cacttccccc gtgtagatca ggtcgatgag tcactgcaat ccccacgggt gaccgtggca      360

gtggctgcgc tggcggcctg cctatggggc aacccatagg acgctctaat gcggacatgg      420

tgcgaagagt ctattgagct agttagtggt cctccggccc ctgaatgcgg ctaatcctaa      480

ctgcggagca catgccttca atccagaggg tagtgtgtcg taatgggcaa ctctgcagcg      540

gaaccgacta ctttgggtgt ccgtgtttcc ttttattctt atattggctg cttatggtga      600

caattacaga attgttacca tatagctatt ggattggcca tccggtgtgc aatagagcta      660

ttatatacct atttgttggc tttgtaccac taaccttaaa atctataacc accctcgact      720

ttatattaac cctcaacaca gtcaagcatg ggctcacagg tgtccactca gcgatccggc      780

tcccacgaga actccaattc agctacagaa ggctccacca ttaattacac taccatcaac      840

tattacaaag actcctatgc tgcgacagcg ggcaaacaga gcctcaaaca agaccctgat      900

aagtttgcta accctgtcaa ggacattttc actgaaatgg ctgcgccact gaagtctcca      960

tccgctgaag cttgtggtta cagtgatcgc gtggcacaac tcaccattgg aaactccacc     1020

attactacac aggaggcggc aaacatcata gttggttacg gtgagtggcc ctcatactgc     1080

tctgatgacg acgctacagc ggtggacaaa ccaacgcgcc cagatgtttc agtgaatagg     1140

ttttatacac tggacactaa actgtgggaa aagtcatcca aggggtggta ttggaagttt     1200

cctgatgtgt tgactgagac cggagtcttt ggccagaacg cacagtttca ctatttgtat     1260

agatcagggt tttgcattca tgtgcaatgt aacgctagca agttccatca aggagcgctg     1320

ttagtcgcca tacttccaga gtatgttata gggacagtgg caggcggtac aggaacagag     1380

gacagccacc ctccttacaa acaaacacaa cctggcgccg acggttttga gctgcagcac     1440

ccgtacgtgc tcgatgctgg gattcctata tcacaattga cagtgtgccc ccatcaatgg     1500

attaacctgc ggaccaataa ctgtgccaca ataatagtgc catatatgaa cacactgcct     1560

ttcgactctg ccctgaacca ttgcaatttt gggctgttgg tagtgcccat tagcccatta     1620

gattttgacc aaggggcaac tccggttatc cctattacaa tcactctagc tccaatgtgc     1680

tctgagtttg caggtctcag acaggcagtc actcaaggct ttcccactga gccaaaacca     1740

ggaacgaatc aattcttgac caccgatgac ggcgtctcag cacccattct accaaatttc     1800

caccccactc catgtattca catacccggt gaagtcagaa acctgcttga gttgtgtcaa     1860

gtggagacta ttcttgaggt taacaacgta cccaccaatg ctaccagtct gatggaaagg     1920

ctacgattcc cggtgtccgc gcaagcgggg aaaggtgaat tgtgtgccgt gtttagggcc     1980

gaccctggaa gagacggtcc atggcaatca acaatgctgg gccagttgtg tggatattac     2040

acccagtggt cagggtcact ggaggtcact tttatgttta ccgggtcttt catggccaca     2100

ggtaaaatgc tcatagctta tacacctcct ggcggcccct tacccaaaga tcgggccaca     2160

gcaatgctgg gcacacatgt tatctgggat tttgggctac aatcatctgt cacccttgta     2220

ataccatgga ttagtaatac ccactacagg gcgcatgccc gggatggagt gttcgactac     2280

tataccacag gactggtcag tatctggtat caaacaaact acgtagttcc aattggggca     2340

cccaacacag cttacataat agcactagcg gcagcccaga agaattttac catgaaactg     2400

tgcaaagaca ccagtcacat attacagaca gcctccattc agggagatag ggtggcagat     2460

gtgatcgaga gctctatagg agatagtgtg agtagggcac ttacccaggc cctgccagca     2520

cccacaggtc aaaacacaca ggtgagcagt catcgactag acactggcga agttccagcg     2580

ctccaagctg ctgaaattgg ggcatcgtca aatactagtg atgagagtat gattgagaca     2640

cgatgcgttc ttaactcaca tagtacagca gagaccacct tggacagttt cttcagtagg     2700

gcaggtttgg taggagagat agatctccct cttaagggta ccaccaatcc aaatggttat     2760

gccaactggg acatagacat aactggttac gcacaaatgc gcaggaaagt ggagctgttc     2820

acctacatgc gctttgatgc ggaattcact tttgttgcgt gcactcctac tggtgaggtt     2880

gttccacaat tactccagta tatgtttgtt ccccctggtg ctcccaaacc agagtctaga     2940

gaatcacttg cttggcagac agccacaaac ccctcagtct ttgtcaagtt gactgatccc     3000

ccggcacagg tctcagttcc gttcatgtca cccgcgagcg cttaccagtg gttttacgac     3060

gggtacccca cgtttggaga acacaaacag gagaaagacc tcgagtatgg agcgtgtcct     3120

aataatatga tgggcacttt ctcggtgcga accgtggggt catcaaagtc caagtacccc     3180

ttggttgtca gaatatatat gagaatgaag catgtcaggg cgtggatacc tcgcccgatg     3240

cgcaaccaaa actatttgtt caaagccaac ccaaactatg ccggtaactc cattaaaccg     3300

accggcacta gtcgtactgc cattactacc cttggaaagt tcggccagca gtctggggcc     3360

atctacgtgg gcaacttcag agtggttaat cgtcacctcg ctactcataa tgactgggcg     3420

aacctcgtct gggaagacag ctcccgcgac ctattagtgt cgtctaccac cgctcagggc     3480

tgtgatacaa ttgcacgttg tgactgtcaa acaggagtgt actattgtaa ttccaagaga     3540

aagcactatc cagtcagctt ttctaaaccc agcctcatat atgtggaagc tagcgagtat     3600

taccctgcta gataccaatc gcacctaatg cttgcagtgg gccactctga gcccggcgac     3660

tgcggaggca tcttaaggtg tcaacatggt gtagttggta tagtgtccac gggtggcaac     3720

gggctcgttg gatttgctga tgtgagggat ctcttgtggt tagatgaaga ggccatggag     3780

caaggtgtgt ccgactacat taaggggctc ggtgatgcgt ttggaacagg cttcactgac     3840

gctgtatcca gggaagttga agcccttagg aaccacctca taggatctga tggagcagtt     3900

gagaaaatcc taaagaacct tattaagctg atttcagcgt tagtaattgt gatcaggagc     3960

gattatgata tggtcaccct cacagcaact ttagccctga ttggttgtca tggaagtcct     4020

tgggcttgga ttaaagccaa gacagcatcc attttaggta tccccatcgc ccagaagcag     4080

agtgcttctt ggctaaagaa atttaatgat atggcgagtg ctgccaaggg tttagaatgg     4140

atatccaata aaattagcaa gttcattgac tggctcaggg agaagattgt tccagcagct     4200

aaggagaaag cagaattttt aaccaatttg aagcaattgc cactattaga gaaccagatc     4260

acaaatttag agcagtccgc tgcctcacaa gaggaccttg aagctatgtt tgggaatgtg     4320

tcatacctcg cccatttctg tcgcaagttc caaccattat acgccacgga agctaagcga     4380

gtctatgttc tagagaagag aatgaacaac tacatgcagt tcaagagcaa acaccgtatt     4440

gaacctgtat gtctcatcat tagaggctca ccaggcactg gaaagtccct tgcgaccggt     4500

atcattgctc gggccatagc agacaagtat cactctagtg tgtactcact tccaccagac     4560

cctgaccatt ttgacgggta caaacagcaa gtggttacag ttatggatga tctgtgtcag     4620

aatcctgacg gcaaagacat gtcattattt tgccagatgg tgtccaccgt ggattttatc     4680

ccaccaatgg cttctctcga agaaaaggga gtttctttca catctaaatt tgttatcgca     4740

tccaccaacg ctagcaacat tatagtgcct acagtgtcag actctgacgc cattcgtcgc     4800

aggttttaca tggattgcga cattgaggtg acagactcat acaaaacaga tttgggtaga     4860

ctagacgctg gacgggctgc taagctatgc tctgagaaca acaccgcaaa cttcaaacga     4920

tgcagcccac tagtgtgtgg gaaagctatt caacttagag acaggaagtc taaggtcagg     4980

tacagcgtgg acacagtggt ctctgaactt attagagaat ataatagcag atccgctatt     5040

ggtaacacaa ttgaagcact attccaaggc ccacccaagt tcaggccaat tagaatcagt     5100

cttgaggaga agccagcccc agacgctatt ggcgatctcc tcgctagtgt agatagcgag     5160

gaagtgcgcc aatactgtag ggagcaaggc tggatcatcc ctgaaactcc caccaatgtt     5220

gaacgacacc ttaatagagc agtgctagtc atgcaatcca tcgctactgt ggtggcagtc     5280

gtctcactgg tgtacgttat ttacaagctc tttgcggggt ttcaaggtgc gtactctgga     5340

gctcccaagc aaatgctcaa gaaacctgtc ctccgtacgg caacagtgca gggtccgagt     5400

cttgactttg ctctatcctt actgagaagg aacatcaggc aagtccaaac agatcaaggg     5460

cattttacca tgttaggtgt cagagatcgc ttagccgttc tcccacggca ctcacagccc     5520

gggaagacta tttgggtgga gcacaaactt gtgaacatcc ttgacgcaat tgagctggtg     5580

gatgagcagg gcgttaattt ggaactcaca ttggtgacac tagatactaa tgaaaaattt     5640

agagatatca ccaagttcat tccagagacc attagcggcg ctagtgatgc aactttagtg     5700

atcaacacag aacatatgcc atcaatgttt gtcccagtgg gggacgtcgt gcagtacggg     5760

ttcttgaacc ttagtggaaa gccaactcat aggaccatga tgtacaattt ccctacaaaa     5820

gcaggacagt gtggaggtgt ggtcacatca gtcggtaaga ttgttggcat tcacattggc     5880

ggcaacgggc gccaagggtt ctgtgctggt ttgaagagga gttacttcgc aagtgtgcag     5940

ggtgagatcc aatgggtgaa gcctaacaag gaaactggta gactgaacat caatggtcca     6000

actcgcacta agctggagcc tagtgtattt catgatgtgt ttgaaggtaa taaggaacca     6060

gcagttttaa caagtaaaga ccctagattg gaggtcgact ttgaacaagc cctgttttcc     6120

aagtatgtgg gcaatgtttt acacgagccc gatgaatacg tgattcaagc tgccctccac     6180

tacgcgaatc aacttaaaca attggacata aacactagca agatgagcat ggaggaagcg     6240

tgctatggca ctgaaaacct ggaagcaata gacctctgca ctagtgccgg gtacccatac     6300

agcgcccttg gcatcaagaa aagagacatt cttgacccca caaccaggga tgtgtctaag     6360

atgaaattct atatggataa atacgggcta gacctgccat actctaccta tgtgaaggat     6420

gagcttaggt ccctggataa aatcaagaaa ggaaaatcac gcttgataga ggctagtagc     6480

ttgaatgact ctgtctacct cagaatgact tttgggcacc tttacgaggt gtttcatgcc     6540

aaccctggca ctgtgactgg ctcagcagtg ggttgcaacc cggacgtgtt ttggagcaaa     6600

ctaccgattc tgctgcctgg gtcactcttt gcctttgact actcaggata tgatgctagt     6660

ctcagcccgg tatggttcag ggctctagaa gttgtgttac gggagattgg gtattcagag     6720

gaggccgtgt ccctaataga agggatcaac cacacccacc atgtgtaccg gaacaaaaca     6780

tactgtgtac ttggtggaat gccctcggga tgttctggta cttccatctt taattcaatg     6840

atcaacaaca tcatcattag aacccttttg atcaaaacct ttaagggaat agacctggat     6900

gagttgaaca tggtggccta tggggacgat gtgctggcta gttacccctt tcccattgat     6960

tgccttgagt tggctaaaac tggcaaagag tatggtttga ccatgacacc tgcagacaaa     7020

tcaccctgtt tcaatgaagt aacatgggaa aatgctacct tcctgaagag aggattcttg     7080

ccagaccacc aatttccatt cttaattcac cctacgatgc ccatgagaga gatccgtgag     7140

tccattcgat ggactaaaga cgcgcgcaac acccaagatc acgtgcgctc cctgtgtctg     7200

ttggcatggc acaatggtaa ggatgaatat gagaagtttg tgagtgtaat tagatcagtt     7260

ccagttggaa aagcgttggc cattcctaat ttcgagaatc tgagaagaaa ttggctcgaa     7320

ttgttttaat attacagctt aaagctgaac cccactagaa atctggtcgc gttaatgact     7380

agtgggggta aatttgttat aaccagaata gcaaaaaaaa aaaaaaaaaa aaaaaaa        7437


<210>  4
<211>  63
<212>  DNA
<213>  Enterovirus 71

<400>  4
ctagggatcc taatacgact cactataggt tcaaacagcc tgtgggttgc acccactcac       60

agg                                                                     63


<210>  5
<211>  54
<212>  DNA
<213>  Enterovirus 71

<400>  5
ctaggacgtc cggccgaact ttccaagggt agtaatggca gtacgactag tgcc             54


<210>  6
<211>  38
<212>  DNA
<213>  Enterovirus 71

<400>  6
taataagctt cggccggcag tctggggcca tctacgtg                               38


<210>  7
<211>  61
<212>  DNA
<213>  Enterovirus 71

<400>  7
gcgcggatcc tttttttttt tttttttttt gctattctgg ttataacaaa tttaccccca       60

c                                                                       61


<210>  8
<211>  58
<212>  DNA
<213>  Enterovirus 71

<400>  8
ggtgtccact caacgcgtcg gctcccacga gaactccaat tcagctacag aaggctcc         58


<210>  9
<211>  45
<212>  DNA
<213>  Enterovirus 71

<400>  9
caagcatggg ctcacaggtg tccactcaac gcgtcggctc ccacg                       45


<210>  10
<211>  48
<212>  DNA
<213>  Enterovirus 71

<400>  10
actcaacgcg tcggctccca cgagaactcc aattcagcta cagaaggc                    48


<210>  11
<211>  49
<212>  DNA
<213>  Enterovirus 71

<400>  11
actgccggcc gaactttcca agggtagtaa tggcagtacg actagtgcc                   49


<210>  12
<211>  44
<212>  DNA
<213>  Enterovirus 71

<400>  12
cagaggacac ccaccctcct tacaaacaaa cacaacctgg cgcc                        44


<210>  13
<211>  34
<212>  DNA
<213>  Enterovirus 71

<400>  13
ggagggtggg tgtcctctgt tcctgtaccg cctg                                   34


<210>  14
<211>  33
<212>  DNA
<213>  Enterovirus 71

<400>  14
ctccttacat acaaacacaa cctggcgccg acg                                    33


<210>  15
<211>  38
<212>  DNA
<213>  Enterovirus 71

<400>  15
tgtgtttgta tgtaaggagg gtggctgtcc tctgttcc                               38


<210>  16
<211>  46
<212>  DNA
<213>  Enterovirus 71

<400>  16
ctccctcttg agggtaccac caatccaaat ggttatgcca actggg                      46


<210>  17
<211>  45
<212>  DNA
<213>  Enterovirus 71

<400>  17
tggtaccctc aagagggaga tctatctctc ctaccaaacc tgccc                       45


<210>  18
<211>  52
<212>  DNA
<213>  Enterovirus 71

<400>  18
ctactggtgc ggttgttcca caattactcc agtatatgtt tgttccccct gg               52


<210>  19
<211>  43
<212>  DNA
<213>  Enterovirus 71

<400>  19
ggaacaaccg caccagtagg agtgcacgca acaaaagtga att                         43


<210>  20
<211>  36
<212>  DNA
<213>  Enterovirus 71

<400>  20
agagaatcat ttgcttggca gacagccaca aacccc                                 36


<210>  21
<211>  40
<212>  DNA
<213>  Enterovirus 71

<400>  21
gccaagcaaa tgattctcta gactctggtt tgggagcacc                             40


<210>  22
<211>  34
<212>  DNA
<213>  Mus musculus

<400>  22
attaggatcc gtctttcaga aggcggtaga ccag                                   34


<210>  23
<211>  43
<212>  DNA
<213>  Mus musculus

<400>  23
tataaagctt cgacacgcca gccacgtgaa aaccaagcca aag                         43


