                         SEQUENCE LISTING

<110>  ISIS INNOVATION LIMITED
 
<120>  BIOMARKER

<130>  N403422WO

<150>  1501480.6
<151>  2015-01-29

<150>  1501511.8
<151>  2015-01-29

<150>  1521446.3
<151>  2015-12-04

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  1686
<212>  DNA
<213>  Homo sapiens

<400>  1
cagacgctcc ctcagcaagg acagcagagg accagctaag agggagagaa gcaactacag       60

accccccctg aaaacaaccc tcagacgcca catcccctga caagctgcca ggcaggttct      120

cttcctctca catactgacc cacggctcca ccctctctcc cctggaaagg acaccatgag      180

cactgaaagc atgatccggg acgtggagct ggccgaggag gcgctcccca agaagacagg      240

ggggccccag ggctccaggc ggtgcttgtt cctcagcctc ttctccttcc tgatcgtggc      300

aggcgccacc acgctcttct gcctgctgca ctttggagtg atcggccccc agagggaaga      360

gttccccagg gacctctctc taatcagccc tctggcccag gcagtcagat catcttctcg      420

aaccccgagt gacaagcctg tagcccatgt tgtagcaaac cctcaagctg aggggcagct      480

ccagtggctg aaccgccggg ccaatgccct cctggccaat ggcgtggagc tgagagataa      540

ccagctggtg gtgccatcag agggcctgta cctcatctac tcccaggtcc tcttcaaggg      600

ccaaggctgc ccctccaccc atgtgctcct cacccacacc atcagccgca tcgccgtctc      660

ctaccagacc aaggtcaacc tcctctctgc catcaagagc ccctgccaga gggagacccc      720

agagggggct gaggccaagc cctggtatga gcccatctat ctgggagggg tcttccagct      780

ggagaagggt gaccgactca gcgctgagat caatcggccc gactatctcg actttgccga      840

gtctgggcag gtctactttg ggatcattgc cctgtgagga ggacgaacat ccaaccttcc      900

caaacgcctc ccctgcccca atccctttat taccccctcc ttcagacacc ctcaacctct      960

tctggctcaa aaagagaatt gggggcttag ggtcggaacc caagcttaga actttaagca     1020

acaagaccac cacttcgaaa cctgggattc aggaatgtgt ggcctgcaca gtgaagtgct     1080

ggcaaccact aagaattcaa actggggcct ccagaactca ctggggccta cagctttgat     1140

ccctgacatc tggaatctgg agaccaggga gcctttggtt ctggccagaa tgctgcagga     1200

cttgagaaga cctcacctag aaattgacac aagtggacct taggccttcc tctctccaga     1260

tgtttccaga cttccttgag acacggagcc cagccctccc catggagcca gctccctcta     1320

tttatgtttg cacttgtgat tatttattat ttatttatta tttatttatt tacagatgaa     1380

tgtatttatt tgggagaccg gggtatcctg ggggacccaa tgtaggagct gccttggctc     1440

agacatgttt tccgtgaaaa cggagctgaa caataggctg ttcccatgta gccccctggc     1500

ctctgtgcct tcttttgatt atgtttttta aaatatttat ctgattaagt tgtctaaaca     1560

atgctgattt ggtgaccaac tgtcactcat tgctgagcct ctgctcccca ggggagttgt     1620

gtctgtaatc gccctactat tcagtggcga gaaataaagt ttgcttagaa aagaaaaaaa     1680

aaaaaa                                                                1686


<210>  2
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230             


<210>  3
<211>  1869
<212>  DNA
<213>  Homo sapiens

<400>  3
gtcaccccca gcgggcgcgg gccggagcac gggcacccag catgggggta ctgctcacac       60

agaggacgct gctcagtctg gtccttgcac tcctgtttcc aagcatggcg agcatggcgg      120

ctataggcag ctgctcgaaa gagtaccgcg tgctccttgg ccagctccag aagcagacag      180

atctcatgca ggacaccagc agactcctgg acccctatat acgtatccaa ggcctggatg      240

ttcctaaact gagagagcac tgcagggagc gccccggggc cttccccagt gaggagaccc      300

tgagggggct gggcaggcgg ggcttcctgc agaccctcaa tgccacactg ggctgcgtcc      360

tgcacagact ggccgactta gagcagcgcc tccccaaggc ccaggatttg gagaggtctg      420

ggctgaacat cgaggacttg gagaagctgc agatggcgag gccgaacatc ctcgggctca      480

ggaacaacat ctactgcatg gcccagctgc tggacaactc agacacggct gagcccacga      540

aggctggccg gggggcctct cagccgccca cccccacccc tgcctcggat gcttttcagc      600

gcaagctgga gggctgcagg ttcctgcatg gctaccatcg cttcatgcac tcagtggggc      660

gggtcttcag caagtggggg gagagcccga accggagccg gagacacagc ccccaccagg      720

ccctgaggaa gggggtgcgc aggaccagac cctccaggaa aggcaagaga ctcatgacca      780

ggggacagct gccccggtag cctcgagagc accccttgcc ggtgaaggat gcggcaggtg      840

ctctgtggat gagaggaacc atcgcaggat gacagctccc gggtccccaa acctgttccc      900

ctctgctact agccactgag aagtgcactt taagaggtgg gagctgggca gacccctcta      960

cctcctccag gctgggagac agagtcaggc tgttgcgctc ccacctcagc cccaagttcc     1020

ccaggcccag tggggtggcc gggcgggcca cgcgggaccg actttccatt gattcagggg     1080

tctgatgaca caggctgact catggccggg ctgactgccc ccctgccttg ctccccgagg     1140

cctgccggtc cttccctctc atgacttgca gggccgttgc ccccagactt cctcctttcc     1200

gtgtttctga aggggaggtc acagcctgag ctggcctcct atgcctcatc atgtcccaaa     1260

ccagacacct ggatgtctgg gtgacctcac tttaggcagc tgtaacagcg gcagggtgtc     1320

ccaggagccc tgatccgggg gtccagggaa tggagctcag gtcccaggcc agccccgaag     1380

tcgccacgtg gcctggggca ggtcacttta cctctgtgga cctgttttct ctttgtgaag     1440

ctagggagtt agaggctgta caaggccccc actgcctgtc ggttgcttgg attccctgac     1500

gtaaggtgga tattaaaaat ctgtaaatca ggacaggtgg tgcaaatggc gctgggaggt     1560

gtacacggag gtctctgtaa aagcagaccc acctcccagc gccgggaagc ccgtcttggg     1620

tcctcgctgc tggctgctcc ccctggtggt ggatcctgga attttctcac gcaggagcca     1680

ttgctctcct agagggggtc tcagaaactg cgaggccagt tccttggagg gacatgacta     1740

atttatcgat ttttatcaat ttttatcagt tttatattta taagccttat ttatgatgta     1800

tatttaatgt taatattgtg caaacttata tttaaaactt gcctggtttc taaaaaaaaa     1860

aaaaaaaaa                                                             1869


<210>  4
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 
1               5                   10                  15      


Leu Leu Phe Pro Ser Met Ala Ser Met Ala Ala Ile Gly Ser Cys Ser 
            20                  25                  30          


Lys Glu Tyr Arg Val Leu Leu Gly Gln Leu Gln Lys Gln Thr Asp Leu 
        35                  40                  45              


Met Gln Asp Thr Ser Arg Leu Leu Asp Pro Tyr Ile Arg Ile Gln Gly 
    50                  55                  60                  


Leu Asp Val Pro Lys Leu Arg Glu His Cys Arg Glu Arg Pro Gly Ala 
65                  70                  75                  80  


Phe Pro Ser Glu Glu Thr Leu Arg Gly Leu Gly Arg Arg Gly Phe Leu 
                85                  90                  95      


Gln Thr Leu Asn Ala Thr Leu Gly Cys Val Leu His Arg Leu Ala Asp 
            100                 105                 110         


Leu Glu Gln Arg Leu Pro Lys Ala Gln Asp Leu Glu Arg Ser Gly Leu 
        115                 120                 125             


Asn Ile Glu Asp Leu Glu Lys Leu Gln Met Ala Arg Pro Asn Ile Leu 
    130                 135                 140                 


Gly Leu Arg Asn Asn Ile Tyr Cys Met Ala Gln Leu Leu Asp Asn Ser 
145                 150                 155                 160 


Asp Thr Ala Glu Pro Thr Lys Ala Gly Arg Gly Ala Ser Gln Pro Pro 
                165                 170                 175     


Thr Pro Thr Pro Ala Ser Asp Ala Phe Gln Arg Lys Leu Glu Gly Cys 
            180                 185                 190         


Arg Phe Leu His Gly Tyr His Arg Phe Met His Ser Val Gly Arg Val 
        195                 200                 205             


Phe Ser Lys Trp Gly Glu Ser Pro Asn Arg Ser Arg Arg His Ser Pro 
    210                 215                 220                 


His Gln Ala Leu Arg Lys Gly Val Arg Arg Thr Arg Pro Ser Arg Lys 
225                 230                 235                 240 


Gly Lys Arg Leu Met Thr Arg Gly Gln Leu Pro Arg 
                245                 250         


<210>  5
<211>  5556
<212>  DNA
<213>  Homo sapiens

<400>  5
gcgcttgccc cgcagctgat tcatagcccc ggcccgggcc gcctctgcac gtccgccccg       60

gagcccgcac ccgcgcccca cgcgccgccg aggactcggc ccggctcgtg gagcccttcg      120

cccgcggcgt gagtaccccc gacccgcccg tccccgctct gctcgcgccc tgccgctgcg      180

ccgccctcgg tggcttttcc gacgggcgag ccccgtgctg tgcgggaaag aatccgacaa      240

cttcgcagcc catcccggct ggacgcgacc gggagtgcag cagcccgttc ccctcctcgg      300

tgccgcctct gcccagcgtt tgcttggctg ggctaccacc tgcgctcgga cggcgctcgg      360

agggtcctcg cccccggcct gcctacctga aaaccagaac tgatggctct atttgcagtc      420

tttcagacaa cattcttctt aacattgctg tccttgagga cttaccagag tgaagtcttg      480

gctgaacgtt taccattgac tcctgtatca cttaaagttt ccaccaattc tacgcgtcag      540

agtttgcact tacaatggac tgtccacaac cttccttatc atcaggaatt gaaaatggta      600

tttcagatcc agatcagtag gattgaaaca tccaatgtca tctgggtggg gaattacagc      660

accactgtga agtggaacca ggttctgcat tggagctggg aatctgagct ccctttggaa      720

tgtgccacac actttgtaag aataaagagt ttggtggacg atgccaagtt ccctgagcca      780

aatttctgga gcaactggag ttcctgggag gaagtcagtg tacaagattc tactggacag      840

gatatattgt tcgttttccc taaagataag ctggtggaag aaggcaccaa tgttaccatt      900

tgttacgttt ctaggaacat tcaaaataat gtatcctgtt atttggaagg gaaacagatt      960

catggagaac aacttgatcc acatgtaact gcattcaact tgaatagtgt gcctttcatt     1020

aggaataaag ggacaaatat ctattgtgag gcaagtcaag gaaatgtcag tgaaggcatg     1080

aaaggcatcg ttctttttgt ctcaaaagta cttgaggagc ccaaggactt ttcttgtgaa     1140

accgaggact tcaagacttt gcactgtact tgggatcctg ggacggacac tgccttgggg     1200

tggtctaaac aaccttccca aagctacact ttatttgaat cattttctgg ggaaaagaaa     1260

ctttgtacac acaaaaactg gtgtaattgg caaataactc aagactcaca agaaacctat     1320

aacttcacac tcatagctga aaattactta aggaagagaa gtgtcaatat cctttttaac     1380

ctgactcatc gagtttattt aatgaatcct tttagtgtca actttgaaaa tgtaaatgcc     1440

acaaatgcca tcatgacctg gaaggtgcac tccataagga ataatttcac atatttgtgt     1500

cagattgaac tccatggtga aggaaaaatg atgcaataca atgtttccat caaggtgaac     1560

ggtgagtact tcttaagtga actggaacct gccacagagt acatggcgcg agtacggtgt     1620

gctgatgcca gccacttctg gaaatggagt gaatggagtg gtcagaactt caccacactt     1680

gaagctgctc cctcagaggc ccctgatgtc tggagaattg tgagcttgga gccaggaaat     1740

catactgtga ccttattctg gaagccatta tcaaaactgc atgccaatgg aaagatcctg     1800

ttctataatg tagttgtaga aaacctagac aaaccatcca gttcagagct ccattccatt     1860

ccagcaccag ccaacagcac aaaactaatc cttgacaggt gttcctacca aatctgcgtc     1920

atagccaaca acagtgtggg tgcttctcct gcttctgtaa tagtcatctc tgcagacccc     1980

gaaaacaaag aggttgagga agaaagaatt gcaggcacag agggtggatt ctctctgtct     2040

tggaaacccc aacctggaga tgttataggc tatgttgtgg actggtgtga ccatacccag     2100

gatgtgctcg gtgatttcca gtggaagaat gtaggtccca ataccacaag cacagtcatt     2160

agcacagatg cttttaggcc aggagttcga tatgacttca gaatttatgg gttatctaca     2220

aaaaggattg cttgtttatt agagaaaaaa acaggatact ctcaggaact tgctccttca     2280

gacaaccctc acgtgctggt ggatacattg acatcccact ccttcactct gagttggaaa     2340

gattactcta ctgaatctca acctggtttt atacaagggt accatgtcta tctgaaatcc     2400

aaggcgaggc agtgccaccc acgatttgaa aaggcagttc tttcagatgg ttcagaatgt     2460

tgcaaataca aaattgacaa cccggaagaa aaggcattga ttgtggacaa cctaaagcca     2520

gaatccttct atgagttttt catcactcca ttcactagtg ctggtgaagg ccccagtgct     2580

acgttcacga aggtcacgac tccggatgaa cactcctcga tgctgattca tatcctactg     2640

cccatggttt tctgcgtctt gctcatcatg gtcatgtgct acttgaaaag tcagtggatc     2700

aaggagacct gttatcctga catccctgac ccttacaaga gcagcatcct gtcattaata     2760

aaattcaagg agaaccctca cctaataata atgaatgtca gtgactgtat cccagatgct     2820

attgaagttg taagcaagcc agaagggaca aagatacagt tcctaggcac taggaagtca     2880

ctcacagaaa ccgagttgac taagcctaac tacctttatc tccttccaac agaaaagaat     2940

cactctggcc ctggcccctg catctgtttt gagaacttga cctataacca ggcagcttct     3000

gactctggct cttgtggcca tgttccagta tccccaaaag ccccaagtat gctgggacta     3060

atgacctcac ctgaaaatgt actaaaggca ctagaaaaaa actacatgaa ctccctggga     3120

gaaatcccag ctggagaaac aagtttgaat tatgtgtccc agttggcttc acccatgttt     3180

ggagacaagg acagtctccc aacaaaccca gtagaggcac cacactgttc agagtataaa     3240

atgcaaatgg cagtctccct gcgtcttgcc ttgcctcccc cgaccgagaa tagcagcctc     3300

tcctcaatta cccttttaga tccaggtgaa cactactgct aaccagcatg ccgatttcat     3360

accttatgct acacagacat taagaagagc agagctggca ccctgtcatc accagtggcc     3420

ttggtcctta atcccagtac gatttgcagg tctggtttat ataagaccac tacagtctgg     3480

ctaggttaaa ggccagaggc tatggaactt aacactcccc attggagcaa gcttgcccta     3540

gagacggcag gatcatggga gcatgcttac cttctgctgt ttgttccagg ctcaccttta     3600

gaacaggaga cttgagcttg acctaaggat atgcattaac cactctacag actcccactc     3660

agtactgtac agggtggctg tggtcctaga agttcagttt ttactgagga aatatttcca     3720

ttaacagcaa ttattatatt gaaggcttta ataaaggcca caggagacat tactatagca     3780

tagattgtca aatgtaaatt tactgagcgt gttttataaa aaactcacag gtgtttgagg     3840

ccaaaacaga ttttagactt accttgaacg gataagaatc tatagttcac tgacacagta     3900

aaattaactc tgtgggtggg ggcggggggc atagctctaa tctaatatat aaaatgtgtg     3960

atgaatcaac aagatttcca caattcttct gtcaagctta ctacagtgaa agaatgggat     4020

tggcaagtaa cttctgactt actgtcagtt gtacttctgc tccatagaca tcagtattct     4080

gccatcattt ttgatgacta cctcagaaca taaaaaggaa cgtatatcac ataattccag     4140

tcacagtttt tggttcctct tttctttcaa gaactatata taaatgacct gttttcactt     4200

agcatccttt ggactctgca gtaggttgtc tgggtcaaga taactctcag tcacatttat     4260

attcatatta tgctaaaata gtaaaatgaa acctcattgt tggacataat ttagatataa     4320

ctaaaaagtt ctatgaagtg ggaaattccg tgttggctct ggagcagctt tgtctcctct     4380

gaaccaatat atcccaaacc aatatatgca aagcacctgg tacacaactg gtattttagt     4440

acatgttggt tcttttggtg caatctcagc tcactgcagc ttccgcctcc tagattcaaa     4500

caaacagttc tcctgcccca gcctccagag cacctaggac tccaggtgca tgctaccaca     4560

cctgactagt ttttatattt ttagtagaga ttgggtttta ccatattggc caggctggtc     4620

tcaaactcct gaccgcaggt gatccacctg cctcagcttc cccaagggct gggattacag     4680

gtgtgagcca ccatgcccag cctatttgtc acattatttg tcacatttat tttactttta     4740

tttatttttt gagatgaaat ttcgctcttg ttgcccaggc tggagtgcaa tggtgcagcc     4800

ttggctcact gcaacctccg cctcccaggg tcaagcaatt ctcctgcctc agcctcctga     4860

gtagctggga ttacaggcat gcaccaccac acccaggtaa ttttgtatct ttagtagaga     4920

tggggtttca ccatgttggt caggctgttc tcgaactcct gacctcaggt gatctgcctg     4980

ccttggcctc ccaaagtgct gggattacag gcgtgagcca ctgcgcctag ccgtcacatt     5040

tctaaacaag catgaaaggg gttcattttt gtcttcttct tgcctgccgt cagcatggtg     5100

gaaatggctc tgcctatgct catgcttctg gtgcccaatg ccttgcactg tgccattcaa     5160

cactatgaag agaaacaagt agccacacct caaaataatg tggctgtcaa caactggcct     5220

aaataaacct acacaaacca gtacttgcct tttgctggaa acattgatta tgtgctcctc     5280

acgtagtaga aagcggtatc ctgattagtc taacagttgt gttagacttt agggccagta     5340

ttgtcagcat ttatttattt atgtaccttt gttatgatgg gatatttttc atttgaaact     5400

tgttcataaa aatgtcaatg acattgatga ctgatttgta catatttttc atatagtttt     5460

gtttaaaaaa taattcacgc aaaatcttga agtcattttt gctattgaaa taaaccttaa     5520

ttaaaatatt tcatcatcaa aaaaaaaaaa aaaaaa                               5556


<210>  6
<211>  979
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Leu Phe Ala Val Phe Gln Thr Thr Phe Phe Leu Thr Leu Leu 
1               5                   10                  15      


Ser Leu Arg Thr Tyr Gln Ser Glu Val Leu Ala Glu Arg Leu Pro Leu 
            20                  25                  30          


Thr Pro Val Ser Leu Lys Val Ser Thr Asn Ser Thr Arg Gln Ser Leu 
        35                  40                  45              


His Leu Gln Trp Thr Val His Asn Leu Pro Tyr His Gln Glu Leu Lys 
    50                  55                  60                  


Met Val Phe Gln Ile Gln Ile Ser Arg Ile Glu Thr Ser Asn Val Ile 
65                  70                  75                  80  


Trp Val Gly Asn Tyr Ser Thr Thr Val Lys Trp Asn Gln Val Leu His 
                85                  90                  95      


Trp Ser Trp Glu Ser Glu Leu Pro Leu Glu Cys Ala Thr His Phe Val 
            100                 105                 110         


Arg Ile Lys Ser Leu Val Asp Asp Ala Lys Phe Pro Glu Pro Asn Phe 
        115                 120                 125             


Trp Ser Asn Trp Ser Ser Trp Glu Glu Val Ser Val Gln Asp Ser Thr 
    130                 135                 140                 


Gly Gln Asp Ile Leu Phe Val Phe Pro Lys Asp Lys Leu Val Glu Glu 
145                 150                 155                 160 


Gly Thr Asn Val Thr Ile Cys Tyr Val Ser Arg Asn Ile Gln Asn Asn 
                165                 170                 175     


Val Ser Cys Tyr Leu Glu Gly Lys Gln Ile His Gly Glu Gln Leu Asp 
            180                 185                 190         


Pro His Val Thr Ala Phe Asn Leu Asn Ser Val Pro Phe Ile Arg Asn 
        195                 200                 205             


Lys Gly Thr Asn Ile Tyr Cys Glu Ala Ser Gln Gly Asn Val Ser Glu 
    210                 215                 220                 


Gly Met Lys Gly Ile Val Leu Phe Val Ser Lys Val Leu Glu Glu Pro 
225                 230                 235                 240 


Lys Asp Phe Ser Cys Glu Thr Glu Asp Phe Lys Thr Leu His Cys Thr 
                245                 250                 255     


Trp Asp Pro Gly Thr Asp Thr Ala Leu Gly Trp Ser Lys Gln Pro Ser 
            260                 265                 270         


Gln Ser Tyr Thr Leu Phe Glu Ser Phe Ser Gly Glu Lys Lys Leu Cys 
        275                 280                 285             


Thr His Lys Asn Trp Cys Asn Trp Gln Ile Thr Gln Asp Ser Gln Glu 
    290                 295                 300                 


Thr Tyr Asn Phe Thr Leu Ile Ala Glu Asn Tyr Leu Arg Lys Arg Ser 
305                 310                 315                 320 


Val Asn Ile Leu Phe Asn Leu Thr His Arg Val Tyr Leu Met Asn Pro 
                325                 330                 335     


Phe Ser Val Asn Phe Glu Asn Val Asn Ala Thr Asn Ala Ile Met Thr 
            340                 345                 350         


Trp Lys Val His Ser Ile Arg Asn Asn Phe Thr Tyr Leu Cys Gln Ile 
        355                 360                 365             


Glu Leu His Gly Glu Gly Lys Met Met Gln Tyr Asn Val Ser Ile Lys 
    370                 375                 380                 


Val Asn Gly Glu Tyr Phe Leu Ser Glu Leu Glu Pro Ala Thr Glu Tyr 
385                 390                 395                 400 


Met Ala Arg Val Arg Cys Ala Asp Ala Ser His Phe Trp Lys Trp Ser 
                405                 410                 415     


Glu Trp Ser Gly Gln Asn Phe Thr Thr Leu Glu Ala Ala Pro Ser Glu 
            420                 425                 430         


Ala Pro Asp Val Trp Arg Ile Val Ser Leu Glu Pro Gly Asn His Thr 
        435                 440                 445             


Val Thr Leu Phe Trp Lys Pro Leu Ser Lys Leu His Ala Asn Gly Lys 
    450                 455                 460                 


Ile Leu Phe Tyr Asn Val Val Val Glu Asn Leu Asp Lys Pro Ser Ser 
465                 470                 475                 480 


Ser Glu Leu His Ser Ile Pro Ala Pro Ala Asn Ser Thr Lys Leu Ile 
                485                 490                 495     


Leu Asp Arg Cys Ser Tyr Gln Ile Cys Val Ile Ala Asn Asn Ser Val 
            500                 505                 510         


Gly Ala Ser Pro Ala Ser Val Ile Val Ile Ser Ala Asp Pro Glu Asn 
        515                 520                 525             


Lys Glu Val Glu Glu Glu Arg Ile Ala Gly Thr Glu Gly Gly Phe Ser 
    530                 535                 540                 


Leu Ser Trp Lys Pro Gln Pro Gly Asp Val Ile Gly Tyr Val Val Asp 
545                 550                 555                 560 


Trp Cys Asp His Thr Gln Asp Val Leu Gly Asp Phe Gln Trp Lys Asn 
                565                 570                 575     


Val Gly Pro Asn Thr Thr Ser Thr Val Ile Ser Thr Asp Ala Phe Arg 
            580                 585                 590         


Pro Gly Val Arg Tyr Asp Phe Arg Ile Tyr Gly Leu Ser Thr Lys Arg 
        595                 600                 605             


Ile Ala Cys Leu Leu Glu Lys Lys Thr Gly Tyr Ser Gln Glu Leu Ala 
    610                 615                 620                 


Pro Ser Asp Asn Pro His Val Leu Val Asp Thr Leu Thr Ser His Ser 
625                 630                 635                 640 


Phe Thr Leu Ser Trp Lys Asp Tyr Ser Thr Glu Ser Gln Pro Gly Phe 
                645                 650                 655     


Ile Gln Gly Tyr His Val Tyr Leu Lys Ser Lys Ala Arg Gln Cys His 
            660                 665                 670         


Pro Arg Phe Glu Lys Ala Val Leu Ser Asp Gly Ser Glu Cys Cys Lys 
        675                 680                 685             


Tyr Lys Ile Asp Asn Pro Glu Glu Lys Ala Leu Ile Val Asp Asn Leu 
    690                 695                 700                 


Lys Pro Glu Ser Phe Tyr Glu Phe Phe Ile Thr Pro Phe Thr Ser Ala 
705                 710                 715                 720 


Gly Glu Gly Pro Ser Ala Thr Phe Thr Lys Val Thr Thr Pro Asp Glu 
                725                 730                 735     


His Ser Ser Met Leu Ile His Ile Leu Leu Pro Met Val Phe Cys Val 
            740                 745                 750         


Leu Leu Ile Met Val Met Cys Tyr Leu Lys Ser Gln Trp Ile Lys Glu 
        755                 760                 765             


Thr Cys Tyr Pro Asp Ile Pro Asp Pro Tyr Lys Ser Ser Ile Leu Ser 
    770                 775                 780                 


Leu Ile Lys Phe Lys Glu Asn Pro His Leu Ile Ile Met Asn Val Ser 
785                 790                 795                 800 


Asp Cys Ile Pro Asp Ala Ile Glu Val Val Ser Lys Pro Glu Gly Thr 
                805                 810                 815     


Lys Ile Gln Phe Leu Gly Thr Arg Lys Ser Leu Thr Glu Thr Glu Leu 
            820                 825                 830         


Thr Lys Pro Asn Tyr Leu Tyr Leu Leu Pro Thr Glu Lys Asn His Ser 
        835                 840                 845             


Gly Pro Gly Pro Cys Ile Cys Phe Glu Asn Leu Thr Tyr Asn Gln Ala 
    850                 855                 860                 


Ala Ser Asp Ser Gly Ser Cys Gly His Val Pro Val Ser Pro Lys Ala 
865                 870                 875                 880 


Pro Ser Met Leu Gly Leu Met Thr Ser Pro Glu Asn Val Leu Lys Ala 
                885                 890                 895     


Leu Glu Lys Asn Tyr Met Asn Ser Leu Gly Glu Ile Pro Ala Gly Glu 
            900                 905                 910         


Thr Ser Leu Asn Tyr Val Ser Gln Leu Ala Ser Pro Met Phe Gly Asp 
        915                 920                 925             


Lys Asp Ser Leu Pro Thr Asn Pro Val Glu Ala Pro His Cys Ser Glu 
    930                 935                 940                 


Tyr Lys Met Gln Met Ala Val Ser Leu Arg Leu Ala Leu Pro Pro Pro 
945                 950                 955                 960 


Thr Glu Asn Ser Ser Leu Ser Ser Ile Thr Leu Leu Asp Pro Gly Glu 
                965                 970                 975     


His Tyr Cys 
            


