                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
 
<120>  Pharmaceutical composition for oral GLP-1 administration 
       comprising a tablet core and Immediate release coating

<130>  150005WO01

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  1

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  2
<211>  39
<212>  PRT
<213>  Heloderma horridum

<400>  2

His Ser Asp Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  3
<211>  39
<212>  PRT
<213>  Heloderma suspectum

<400>  3

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  4
<211>  33
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Based on human GLP-1


<220>
<221>  SITE
<222>  (1)..(1)
<223>  This residue is L-His, imidazopropionyl, alpha-hydroxy-histidine,
       D-His, desamino-His, 2-amino-His, beta-hydroxy-His, homo-His, 
       N-alpha-acetyl-His, N-alpha-formyl-His, alpha-fluoromethyl-His, 
       alpha-methyl-His, 3-pyridyl-Ala, 2-pyridyl-Ala, or 4-pyridyl-Ala

<220>
<221>  SITE
<222>  (2)..(2)
<223>  This residue is Ala, Gly, Val, Leu, Ile, Thr, Ser, Lys, Aib, 
       (1-aminocyclopropyl) carboxylic acid, (1-aminocyclobutyl) 
       carboxylic acid (CA), (1-aminocyclopentyl) CA, 
       (1-aminocyclohexyl) CA, (1-aminocycloheptyl) CA, or 
       

<220>
<221>  SITE
<222>  (6)..(6)
<223>  This residue is Lys or Phe

<220>
<221>  SITE
<222>  (10)..(10)
<223>  This residue is Val or Leu

<220>
<221>  SITE
<222>  (12)..(12)
<223>  This residue is Ser, Arg, Asn, Gln, or Glu

<220>
<221>  SITE
<222>  (13)..(13)
<223>  This residue is Tyr or Gln

<220>
<221>  SITE
<222>  (14)..(14)
<223>  This residue is Leu, Lys, or Met

<220>
<221>  SITE
<222>  (16)..(16)
<223>  This residue is Gly, Glu, Lys, or Aib

<220>
<221>  SITE
<222>  (17)..(17)
<223>  This residue is Gln, Glu, or Arg

<220>
<221>  SITE
<222>  (18)..(18)
<223>  This residue is Ala or Lys

<220>
<221>  SITE
<222>  (19)..(19)
<223>  This residue is Ala or Val

<220>
<221>  SITE
<222>  (20)..(20)
<223>  This residue is Val, His, Lys or Arg

<220>
<221>  SITE
<222>  (24)..(24)
<223>  This residue is Ala, Glu, or Arg

<220>
<221>  SITE
<222>  (25)..(25)
<223>  This residue is Trp or His

<220>
<221>  SITE
<222>  (28)..(28)
<223>  This residue is Glu, Asn, Gly, Gln, or Arg

<220>
<221>  SITE
<222>  (29)..(29)
<223>  This residue is Gly, Aib, or absent

<220>
<221>  SITE
<222>  (30)..(30)
<223>  This residue is Arg, Gly, Lys, or absent

<220>
<221>  SITE
<222>  (31)..(31)
<223>  This residue is Gly, Ala, Glu, Pro, Lys, Arg, or absent

<220>
<221>  SITE
<222>  (32)..(32)
<223>  This residue is Ser, Gly, Ala, Glu, Gln, Pro, Arg, or absent

<220>
<221>  SITE
<222>  (33)..(33)
<223>  This residue is Gly or absent

<400>  4

Xaa Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Xaa Xaa Xaa Glu Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Lys Phe Ile Xaa Xaa Leu Val Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa 
    


<210>  5
<211>  29
<212>  PRT
<213>  Heloderma suspectum

<400>  5

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly 
            20                  25                  


<210>  6
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  6

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  7
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Based on human GLP-1


<220>
<221>  SITE
<222>  (1)..(1)
<223>  L-histidine, (S)-2-Hydroxy-3-(1H-imidazol-4-yl)-propionic acid, 
       D-histidine, desamino-histidine (desH), N?-acetyl-histidine, 
       N?-formyl-histidine

<220>
<221>  SITE
<222>  (2)..(2)
<223>  Ala, Ser, Aib, (1-aminocyclopropyl) carboxylic acid, 
       (1-aminocyclobutyl) carboxylic acid

<220>
<221>  SITE
<222>  (8)..(8)
<223>  Val or Leu

<220>
<221>  SITE
<222>  (10)..(10)
<223>  Ser or Arg

<220>
<221>  SITE
<222>  (11)..(11)
<223>  Tyr or Gln

<220>
<221>  SITE
<222>  (12)..(12)
<223>  Leu or Met

<220>
<221>  SITE
<222>  (14)..(14)
<223>  Gly or Glu

<220>
<221>  SITE
<222>  (15)..(15)
<223>  Gln, Glu, or Arg

<220>
<221>  SITE
<222>  (17)..(17)
<223>  Ala or Val

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (19)..(19)
<223>  Glu or Leu

<220>
<221>  SITE
<222>  (22)..(22)
<223>  Ala, or Glu

<220>
<221>  SITE
<222>  (23)..(23)
<223>  Trp or His

<220>
<221>  SITE
<222>  (25)..(25)
<223>  Val or Arg

<220>
<221>  SITE
<222>  (26)..(26)
<223>  Arg, Lys, His, Asn, or Gln

<220>
<221>  SITE
<222>  (27)..(27)
<223>  Gly or Aib

<400>  7

Xaa Xaa Glu Gly Thr Ser Asp Xaa Ser Xaa Xaa Xaa Glu Xaa Xaa Ala 
1               5                   10                  15      


Xaa Xaa Xaa Phe Ile Xaa Xaa Leu Xaa Xaa Xaa Lys Lys 
            20                  25                  


