                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
 
<120>  TABLETS COMPRISING GLP-1 AGONIST AND ENTERIC COATING

<130>  140092WO01

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  1

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  2
<211>  39
<212>  PRT
<213>  Heloderma suspectum

<400>  2

His Ser Asp Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  3
<211>  39
<212>  PRT
<213>  Heloderma suspectum

<400>  3

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  4
<211>  33
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Based on human GLP-1


<220>
<221>  SITE
<222>  (1)..(1)
<223>  This residue is L-His, imidazopropionyl, alpha-hydroxy-histidine,
       D-His, desamino-His, 2-amino-His, beta-hydroxy-His, homo-His, 
       N-alpha-acetyl-His, N-alpha-formyl-His, alpha-fluoromethyl-His, 
       alpha-methyl-His, 3-pyridyl-Ala, 2-pyridyl-Ala, or 4-pyridyl-Ala

<220>
<221>  SITE
<222>  (2)..(2)
<223>  This residue is Ala, Gly, Val, Leu, Ile, Thr, Ser, Lys, Aib, 
       (1-aminocyclopropyl) carboxylic acid, (1-aminocyclobutyl) 
       carboxylic acid (CA), (1-aminocyclopentyl) CA, 
       (1-aminocyclohexyl) CA, (1-aminocycloheptyl) CA, or 
       

<220>
<221>  SITE
<222>  (6)..(6)
<223>  This residue is Lys or Phe

<220>
<221>  SITE
<222>  (10)..(10)
<223>  This residue is Val or Leu

<220>
<221>  SITE
<222>  (12)..(12)
<223>  This residue is Ser, Arg, Asn, Gln, or Glu

<220>
<221>  SITE
<222>  (13)..(13)
<223>  This residue is Tyr or Gln

<220>
<221>  SITE
<222>  (14)..(14)
<223>  This residue is Leu, Lys, or Met

<220>
<221>  SITE
<222>  (16)..(16)
<223>  This residue is Gly, Glu, Lys, or Aib

<220>
<221>  SITE
<222>  (17)..(17)
<223>  This residue is Gln, Glu, or Arg

<220>
<221>  SITE
<222>  (18)..(18)
<223>  This residue is Ala or Lys

<220>
<221>  SITE
<222>  (19)..(19)
<223>  This residue is Ala or Val

<220>
<221>  SITE
<222>  (20)..(20)
<223>  This residue is Val, His, Lys or Arg

<220>
<221>  SITE
<222>  (24)..(24)
<223>  This residue is Ala, Glu, or Arg

<220>
<221>  SITE
<222>  (25)..(25)
<223>  This residue is Trp or His

<220>
<221>  SITE
<222>  (28)..(28)
<223>  This residue is Glu, Asn, Gly, Gln, or Arg

<220>
<221>  SITE
<222>  (29)..(29)
<223>  This residue is Gly, Aib, or absent

<220>
<221>  SITE
<222>  (30)..(30)
<223>  This residue is Arg, Gly, Lys, or absent

<220>
<221>  SITE
<222>  (31)..(31)
<223>  This residue is Gly, Ala, Glu, Pro, Lys, Arg, or absent

<220>
<221>  SITE
<222>  (32)..(32)
<223>  This residue is Ser, Gly, Ala, Glu, Gln, Pro, Arg, or absent

<220>
<221>  SITE
<222>  (33)..(33)
<223>  This residue is Gly or absent

<400>  4

Xaa Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Xaa Xaa Xaa Glu Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Lys Phe Ile Xaa Xaa Leu Val Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa 
    


<210>  5
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Based on human GLP-1


<220>
<221>  SITE
<222>  (2)..(2)
<223>  This amino acid residue is Aib

<220>
<221>  SITE
<222>  (20)..(20)
<223>  This amino acid residue is covalently attached to a substituent

<220>
<221>  SITE
<222>  (31)..(31)
<223>  This amino acid residue is covalently attached to a substituent

<400>  5

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys 
            20                  25                  30      


<210>  6
<211>  33
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Based on human GLP-1


<220>
<221>  SITE
<222>  (2)..(2)
<223>  This amino acid residue is Aib

<220>
<221>  SITE
<222>  (21)..(21)
<223>  This amino acid residue is covalently attached to a substituent

<220>
<221>  SITE
<222>  (30)..(30)
<223>  This amino acid residue is covalently attached to a substituent

<400>  6

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Gly Trp Leu Val Arg Gly Lys Gly Glu 
            20                  25                  30          


Gly 
    


<210>  7
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Based on human GLP-1


<220>
<221>  SITE
<222>  (1)..(1)
<223>  This residue (Xaa7) is L-His, 
       (S)-2-Hydroxy-3-(1H-imidazol-4-yl)-propionic acid, D-His, 
       desamino-His, Nalpha-acetyl-His, or Nalpha-formyl-His

<220>
<221>  SITE
<222>  (2)..(2)
<223>  This residue (Xaa8) is Ala, Ser, Aib, (1-aminocyclopropyl) 
       carboxylic acid, or (1-aminocyclobutyl) carboxylic acid

<220>
<221>  SITE
<222>  (10)..(10)
<223>  This residue (Xaa16) is Val or Leu

<220>
<221>  SITE
<222>  (12)..(12)
<223>  This residue (Xaa18) is Ser or Arg

<220>
<221>  SITE
<222>  (13)..(13)
<223>  This residue (Xaa19) is Tyr or Gln

<220>
<221>  SITE
<222>  (14)..(14)
<223>  This residue (Xaa20) is Leu or Met

<220>
<221>  SITE
<222>  (16)..(16)
<223>  This residue (Xaa22) is Gly or Glu

<220>
<221>  SITE
<222>  (17)..(17)
<223>  This residue (Xaa23) is Gln, Glu, or Arg

<220>
<221>  SITE
<222>  (19)..(19)
<223>  This residue (Xaa25) is Ala or Val

<220>
<221>  SITE
<222>  (20)..(20)
<223>  This residue (Xaa26) is Arg or Lys

<220>
<221>  SITE
<222>  (21)..(21)
<223>  This residue (Xaa27) is Glu or Leu

<220>
<221>  SITE
<222>  (24)..(24)
<223>  This residue (Xaa30) is Ala or Glu

<220>
<221>  SITE
<222>  (25)..(25)
<223>  This residue (Xaa31) is Trp or His

<220>
<221>  SITE
<222>  (27)..(27)
<223>  This residue (Xaa33) is Val or Arg

<220>
<221>  SITE
<222>  (28)..(28)
<223>  This residue (Xaa34) is Arg, Lys, His, Asn, or Gln

<220>
<221>  SITE
<222>  (29)..(29)
<223>  This residue (Xaa35) is Gly or Aib

<400>  7

Xaa Xaa Glu Gly Thr Phe Thr Ser Asp Xaa Ser Xaa Xaa Xaa Glu Xaa 
1               5                   10                  15      


Xaa Ala Xaa Xaa Xaa Phe Ile Xaa Xaa Leu Xaa Xaa Xaa Lys Lys 
            20                  25                  30      


<210>  8
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Based on human GLP-1


<220>
<221>  SITE
<222>  (2)..(2)
<223>  This amino acid residue is Aib

<220>
<221>  SITE
<222>  (30)..(30)
<223>  This amino acid residue is covalently attached to a substituent

<220>
<221>  SITE
<222>  (31)..(31)
<223>  This amino acid residue is covalently attached to a substituent

<400>  8

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Lys 
            20                  25                  30      


<210>  9
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Based on human GLP-1


<220>
<221>  SITE
<222>  (2)..(2)
<223>  This amino acid residue is Aib

<220>
<221>  SITE
<222>  (30)..(30)
<223>  This amino acid residue is covalently attached to a substituent

<220>
<221>  SITE
<222>  (31)..(31)
<223>  This amino acid residue is covalently attached to a substituent

<400>  9

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Lys 
            20                  25                  30      


<210>  10
<211>  31
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  GLP-1 agonist based on from human GLP-1


<220>
<221>  SITE
<222>  (2)..(2)
<223>  Aib

<220>
<221>  SITE
<222>  (30)..(30)
<223>  This amino acid residue is covalently attached to a substituent

<220>
<221>  SITE
<222>  (31)..(31)
<223>  This amino acid residue is covalently attached to a substituent

<400>  10

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Lys 
            20                  25                  30      


