                         SEQUENCE LISTING

<110>  Danmarks Tekniske Universitet
 
<120>  Genetically modified microorganisms having improved tolerance 
       towards L-serine

<130>  P81600399PCT00

<150>  EP15152643
<151>  2015-01-27

<160>  104   

<170>  PatentIn version 3.5

<210>  1
<211>  1365
<212>  DNA
<213>  Escherichia coli

<400>  1
gtgattagtc tattcgacat gtttaaggtg gggattggtc cctcatcttc ccataccgta       60

gggcctatga aggcaggtaa acagttcgtc gatgatctgg tcgaaaaagg cttactggat      120

agcgttactc gcgttgccgt ggacgtttat ggttcactgt cgctgacggg taaaggccac      180

cacaccgata tcgccattat tatgggtctt gcaggtaacg aacctgccac cgtggatatc      240

gacagtattc ccggttttat tcgcgacgta gaagagcgcg aacgtctgct gctggcacag      300

ggacggcatg aagtggattt cccgcgcgac aacgggatgc gttttcataa cggcaacctg      360

ccgctgcatg aaaacggtat gcaaatccac gcctataacg gcgatgaagt cgtctacagc      420

aaaacttatt attccatcgg cggcggtttt atcgtcgatg aagaacactt tggtcaggat      480

gctgccaacg aagtaagcgt gccgtatccg ttcaaatctg ccaccgaact gctcgcgtac      540

tgtaatgaaa ccggctattc gctgtctggt ctcgctatgc agaacgaact ggcgctgcac      600

agcaagaaag agatcgacga gtatttcgcg catgtctggc aaaccatgca ggcatgtatc      660

gatcgcggga tgaacaccga aggtgtactg ccaggcccgc tgcgcgtgcc acgtcgtgcg      720

tctgccctgc gccggatgct ggtttccagc gataaactgt ctaacgatcc gatgaatgtc      780

attgactggg taaacatgtt tgcgctggca gttaacgaag aaaacgccgc cggtggtcgt      840

gtggtaactg cgccaaccaa cggtgcctgc ggtatcgttc cggcagtgct ggcttactat      900

gaccacttta ttgaatcggt cagcccggac atctataccc gttactttat ggcagcgggc      960

gcgattggtg cattgtataa aatgaacgcc tctatttccg gtgcggaagt tggttgccag     1020

ggcgaagtgg gtgttgcctg ttcaatggct gctgcgggtc ttgcagaact gctgggcggt     1080

agcccggaac aggtttgcgt ggcggcggaa attggcatgg aacacaacct tggtttaacc     1140

tgcgacccgg ttgcagggca ggttcaggtg ccgtgcattg agcgtaatgc cattgcctct     1200

gtgaaggcga ttaacgccgc gcggatggct ctgcgccgca ccagtgcacc gcgcgtctcg     1260

ctggataagg tcatcgaaac gatgtacgaa accggtaagg acatgaacgc caaataccgc     1320

gaaacctcac gcggtggtct ggcaatcaaa gtccagtgtg actaa                     1365


<210>  2
<211>  1368
<212>  DNA
<213>  Escherichia coli

<400>  2
atgattagcg tattcgatat tttcaaaatc ggcattggcc cttccagttc tcataccgtt       60

ggaccaatga aagcgggtaa acaatttacc gacgatctga ttgcccgtaa cctgcttaaa      120

gacgtgaccc gcgtggtggt tgacgtgtac ggctcgctct ctctgaccgg taaaggccac      180

cacactgata tcgccattat tatgggcctg gcgggtaacc tgccggatac cgtggatatc      240

gattccatcc ccagttttat tcaggatgtg aatactcatg gtcgcctgat gctggcaaac      300

ggtcagcatg aagtggagtt cccggttgat cagtgcatga acttccacgc cgacaacctt      360

tctctgcatg aaaacggtat gcgcattacc gcgctggcgg gcgataaagt cgtttacagc      420

cagacttact actctattgg cggtggcttt atcgttgatg aagagcattt tggccagcag      480

gatagcgcac cggttgaagt tccttatccg tacagttcag cagccgatct gcaaaaacat      540

tgtcaggaaa ccgggctgtc actctctggc ctgatgatga aaaacgagct ggcgctgcac      600

agcaaagaag agctggaaca gcacctggcg aacgtctggg aagtcatgcg cggcggtatt      660

gagcgcggta tttccaccga aggcgtgttg cctggcaaac tgcgcgttcc acgccgtgct      720

gcggcactac gccggatgct ggtcagccag gataaaacca ccactgaccc gatggcggtt      780

gttgactgga tcaacatgtt tgcactggca gtgaacgaag agaacgctgc tggcggtcgc      840

gtggtgactg cgccgactaa cggtgcgtgc gggattatcc cggcagttct ggcgtactac      900

gacaagttta tccgcgaagt gaacgctaac tcactggctc gttacctgct ggtagccagc      960

gccattggtt ctctttataa gatgaacgcg tcgatttctg gtgctgaagt gggttgccag     1020

ggtgaagttg gcgtggcgtg ctcaatggcg gcggctggtc tggcagaact attaggcgca     1080

agcccggcgc aggtgtgcat cgcggcggaa atcgccatgg agcacaacct cggtctgacg     1140

tgtgacccgg tcgccggaca ggtacaggtg ccatgcatcg agcgtaacgc cattgcggca     1200

gtaaaagcgg tgaacgccgc acgtatggcg ctgcgccgta ccagcgagcc gcgcgtctgc     1260

ctcgataaag ttatcgaaac catgtacgaa acaggtaaag atatgaacgc caagtaccgc     1320

gaaacctctc gcggcggcct ggcaatgaag atcgttgcct gcgattaa                  1368


<210>  3
<211>  1365
<212>  DNA
<213>  Escherichia coli

<400>  3
atgattagtg cattcgatat tttcaaaatt gggattggtc cctccagttc gcataccgtg       60

gggccaatga atgccggaaa aagttttatt gatcggctgg aaagtagcgg cttattaacc      120

gcgacgagcc atattgtggt cgatctgtac gggtcgttgt cactgacggg caaaggccat      180

gccacggatg tcgccatcat catgggactg gcaggaaaca gtccgcagga tgttgtcatt      240

gatgagatcc ctgcatttat agagttagta acgcgcagcg ggcggctgcc agtggcatct      300

ggtgcgcata ttgttgattt tcctgtagca aagaacatta tcttccatcc cgaaatgttg      360

cctcgccatg agaacggaat gcggatcact gcctggaagg gacaggaaga gctattaagt      420

aaaacctatt actctgtcgg cggcgggttt attgtcgaag aagaacactt cggcctgtcg      480

cacgatgtcg aaacgtccgt accttacgat ttccactcag caggtgaact gctgaaaatg      540

tgtgattaca acggcctgtc tatatctggt ctgatgatgc acaacgagct agcgctgcgc      600

agcaaagcgg aaattgacgc cggttttgcc cgtatctggc aagtgatgca tgacggtatt      660

gaacgtggga tgaacactga aggcgtgctg cctggtccgc tcaatgtgcc gcgccgtgcc      720

gtagcgctgc gtcgtcagct ggtttccagc gataacatct ctaacgatcc gatgaatgtc      780

atcgactgga tcaacatgta cgcgctggcg gttagtgaag aaaacgcagc tggcgggcgc      840

gtggtaacgg caccgactaa cggtgcgtgc ggcattattc cggcagtact ggcttattac      900

gataagttcc gtcgtccggt aaacgagcgg tcaattgccc gctattttct ggccgcgggg      960

gctattggcg cgctgtataa aatgaacgcc tccatctctg gcgcggaagt cggctgtcag     1020

ggggagattg gcgtggcctg ttcaatggcg gcggcagggt taactgaact actgggcggc     1080

agtccggcgc aggtatgcaa tgcggcggaa atcgcgatgg agcataacct tgggctgacc     1140

tgcgatccgg ttgccggaca ggtacaaatc ccgtgcattg aacgtaatgc cattaatgcc     1200

gtgaaagcag taaacgccgc gcggatggcg atgcgccgca cctcggcacc gcgtgtttca     1260

ctcgataaag tgatcgagac gatgtatgaa accggcaaag atatgaacga taaataccgc     1320

gaaacatcac gcggaggact ggccattaaa gtggtctgcg gctga                     1365


<210>  4
<211>  1254
<212>  DNA
<213>  Escherichia coli

<400>  4
atgttaaagc gtgaaatgaa cattgccgat tatgatgccg aactgtggca ggctatggag       60

caggaaaaag tacgtcagga agagcacatc gaactgatcg cctccgaaaa ctacaccagc      120

ccgcgcgtaa tgcaggcgca gggttctcag ctgaccaaca aatatgctga aggttatccg      180

ggcaaacgct actacggcgg ttgcgagtat gttgatatcg ttgaacaact ggcgatcgat      240

cgtgcgaaag aactgttcgg cgctgactac gctaacgtcc agccgcactc cggctcccag      300

gctaactttg cggtctacac cgcgctgctg gaaccaggtg ataccgttct gggtatgaac      360

ctggcgcatg gcggtcacct gactcacggt tctccggtta acttctccgg taaactgtac      420

aacatcgttc cttacggtat cgatgctacc ggtcatatcg actacgccga tctggaaaaa      480

caagccaaag aacacaagcc gaaaatgatt atcggtggtt tctctgcata ttccggcgtg      540

gtggactggg cgaaaatgcg tgaaatcgct gacagcatcg gtgcttacct gttcgttgat      600

atggcgcacg ttgcgggcct ggttgctgct ggcgtctacc cgaacccggt tcctcatgct      660

cacgttgtta ctaccaccac tcacaaaacc ctggcgggtc cgcgcggcgg cctgatcctg      720

gcgaaaggtg gtagcgaaga gctgtacaaa aaactgaact ctgccgtttt ccctggtggt      780

cagggcggtc cgttgatgca cgtaatcgcc ggtaaagcgg ttgctctgaa agaagcgatg      840

gagcctgagt tcaaaactta ccagcagcag gtcgctaaaa acgctaaagc gatggtagaa      900

gtgttcctcg agcgcggcta caaagtggtt tccggcggca ctgataacca cctgttcctg      960

gttgatctgg ttgataaaaa cctgaccggt aaagaagcag acgccgctct gggccgtgct     1020

aacatcaccg tcaacaaaaa cagcgtaccg aacgatccga agagcccgtt tgtgacctcc     1080

ggtattcgtg taggtactcc ggcgattacc cgtcgcggct ttaaagaagc cgaagcgaaa     1140

gaactggctg gctggatgtg tgacgtgctg gacagcatca atgatgaagc cgttatcgag     1200

cgcatcaaag gtaaagttct cgacatctgc gcacgttacc cggtttacgc ataa           1254


<210>  5
<211>  410
<212>  PRT
<213>  Escherichia coli

<400>  5

Met Ala Lys Val Ser Leu Glu Lys Asp Lys Ile Lys Phe Leu Leu Val 
1               5                   10                  15      


Glu Gly Val His Gln Lys Ala Leu Glu Ser Leu Arg Ala Ala Gly Tyr 
            20                  25                  30          


Thr Asn Ile Glu Phe His Lys Gly Ala Leu Asp Asp Glu Gln Leu Lys 
        35                  40                  45              


Glu Ser Ile Arg Asp Ala His Phe Ile Gly Leu Arg Ser Arg Thr His 
    50                  55                  60                  


Leu Thr Glu Asp Val Ile Asn Ala Ala Glu Lys Leu Val Ala Ile Gly 
65                  70                  75                  80  


Cys Phe Cys Ile Gly Thr Asn Gln Val Asp Leu Asp Ala Ala Ala Lys 
                85                  90                  95      


Arg Gly Ile Pro Val Phe Asn Ala Pro Phe Ser Asn Thr Arg Ser Val 
            100                 105                 110         


Ala Glu Leu Val Ile Gly Glu Leu Leu Leu Leu Leu Arg Gly Val Pro 
        115                 120                 125             


Glu Ala Asn Ala Lys Ala His Arg Gly Val Trp Asn Lys Leu Ala Ala 
    130                 135                 140                 


Gly Ser Phe Glu Ala Arg Gly Lys Lys Leu Gly Ile Ile Gly Tyr Gly 
145                 150                 155                 160 


His Ile Gly Thr Gln Leu Gly Ile Leu Ala Glu Ser Leu Gly Met Tyr 
                165                 170                 175     


Val Tyr Phe Tyr Asp Ile Glu Asn Lys Leu Pro Leu Gly Asn Ala Thr 
            180                 185                 190         


Gln Val Gln His Leu Ser Asp Leu Leu Asn Met Ser Asp Val Val Ser 
        195                 200                 205             


Leu His Val Pro Glu Asn Pro Ser Thr Lys Asn Met Met Gly Ala Lys 
    210                 215                 220                 


Glu Ile Ser Leu Met Lys Pro Gly Ser Leu Leu Ile Asn Ala Ser Arg 
225                 230                 235                 240 


Gly Thr Val Val Asp Ile Pro Ala Leu Cys Asp Ala Leu Ala Ser Lys 
                245                 250                 255     


His Leu Ala Gly Ala Ala Ile Asp Val Phe Pro Thr Glu Pro Ala Thr 
            260                 265                 270         


Asn Ser Asp Pro Phe Thr Ser Pro Leu Cys Glu Phe Asp Asn Val Leu 
        275                 280                 285             


Leu Thr Pro His Ile Gly Gly Ser Thr Gln Glu Ala Gln Glu Asn Ile 
    290                 295                 300                 


Gly Leu Glu Val Ala Gly Lys Leu Ile Lys Tyr Ser Asp Asn Gly Ser 
305                 310                 315                 320 


Thr Leu Ser Ala Val Asn Phe Pro Glu Val Ser Leu Pro Leu His Gly 
                325                 330                 335     


Gly Arg Arg Leu Met His Ile His Glu Asn Arg Pro Gly Val Leu Thr 
            340                 345                 350         


Ala Leu Asn Lys Ile Phe Ala Glu Gln Gly Val Asn Ile Ala Ala Gln 
        355                 360                 365             


Tyr Leu Gln Thr Ser Ala Gln Met Gly Tyr Val Val Ile Asp Ile Glu 
    370                 375                 380                 


Ala Asp Glu Asp Val Ala Glu Lys Ala Leu Gln Ala Met Lys Ala Ile 
385                 390                 395                 400 


Pro Gly Thr Ile Arg Ala Arg Leu Leu Tyr 
                405                 410 


<210>  6
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant SerA

<400>  6

Met Ala Lys Val Ser Leu Glu Lys Asp Lys Ile Lys Phe Leu Leu Val 
1               5                   10                  15      


Glu Gly Val His Gln Lys Ala Leu Glu Ser Leu Arg Ala Ala Gly Tyr 
            20                  25                  30          


Thr Asn Ile Glu Phe His Lys Gly Ala Leu Asp Asp Glu Gln Leu Lys 
        35                  40                  45              


Glu Ser Ile Arg Asp Ala His Phe Ile Gly Leu Arg Ser Arg Thr His 
    50                  55                  60                  


Leu Thr Glu Asp Val Ile Asn Ala Ala Glu Lys Leu Val Ala Ile Gly 
65                  70                  75                  80  


Cys Phe Cys Ile Gly Thr Asn Gln Val Asp Leu Asp Ala Ala Ala Lys 
                85                  90                  95      


Arg Gly Ile Pro Val Phe Asn Ala Pro Phe Ser Asn Thr Arg Ser Val 
            100                 105                 110         


Ala Glu Leu Val Ile Gly Glu Leu Leu Leu Leu Leu Arg Gly Val Pro 
        115                 120                 125             


Glu Ala Asn Ala Lys Ala His Arg Gly Val Trp Asn Lys Leu Ala Ala 
    130                 135                 140                 


Gly Ser Phe Glu Ala Arg Gly Lys Lys Leu Gly Ile Ile Gly Tyr Gly 
145                 150                 155                 160 


His Ile Gly Thr Gln Leu Gly Ile Leu Ala Glu Ser Leu Gly Met Tyr 
                165                 170                 175     


Val Tyr Phe Tyr Asp Ile Glu Asn Lys Leu Pro Leu Gly Asn Ala Thr 
            180                 185                 190         


Gln Val Gln His Leu Ser Asp Leu Leu Asn Met Ser Asp Val Val Ser 
        195                 200                 205             


Leu His Val Pro Glu Asn Pro Ser Thr Lys Asn Met Met Gly Ala Lys 
    210                 215                 220                 


Glu Ile Ser Leu Met Lys Pro Gly Ser Leu Leu Ile Asn Ala Ser Arg 
225                 230                 235                 240 


Gly Thr Val Val Asp Ile Pro Ala Leu Cys Asp Ala Leu Ala Ser Lys 
                245                 250                 255     


His Leu Ala Gly Ala Ala Ile Asp Val Phe Pro Thr Glu Pro Ala Thr 
            260                 265                 270         


Asn Ser Asp Pro Phe Thr Ser Pro Leu Cys Glu Phe Asp Asn Val Leu 
        275                 280                 285             


Leu Thr Pro His Ile Gly Gly Ser Thr Gln Glu Ala Gln Glu Asn Ile 
    290                 295                 300                 


Gly Leu Glu Val Ala Gly Lys Leu Ile Lys Tyr Ser Asp Asn Gly Ser 
305                 310                 315                 320 


Thr Leu Ser Ala Val Asn Phe Pro Glu Val Ser Leu Pro Leu His Gly 
                325                 330                 335     


Gly Arg Arg Leu Met His Ile Ala Glu Ala Arg Pro Gly Val Leu Thr 
            340                 345                 350         


Ala Leu Asn Lys Ile Phe Ala Glu Gln Gly Val Ala Ile Ala Ala Gln 
        355                 360                 365             


Tyr Leu Gln Thr Ser Ala Gln Met Gly Tyr Val Val Ile Asp Ile Glu 
    370                 375                 380                 


Ala Asp Glu Asp Val Ala Glu Lys Ala Leu Gln Ala Met Lys Ala Ile 
385                 390                 395                 400 


Pro Gly Thr Ile Arg Ala Arg Leu Leu Tyr 
                405                 410 


<210>  7
<211>  322
<212>  PRT
<213>  Escherichia coli

<400>  7

Met Pro Asn Ile Thr Trp Cys Asp Leu Pro Glu Asp Val Ser Leu Trp 
1               5                   10                  15      


Pro Gly Leu Pro Leu Ser Leu Ser Gly Asp Glu Val Met Pro Leu Asp 
            20                  25                  30          


Tyr His Ala Gly Arg Ser Gly Trp Leu Leu Tyr Gly Arg Gly Leu Asp 
        35                  40                  45              


Lys Gln Arg Leu Thr Gln Tyr Gln Ser Lys Leu Gly Ala Ala Met Val 
    50                  55                  60                  


Ile Val Ala Ala Trp Cys Val Glu Asp Tyr Gln Val Ile Arg Leu Ala 
65                  70                  75                  80  


Gly Ser Leu Thr Ala Arg Ala Thr Arg Leu Ala His Glu Ala Gln Leu 
                85                  90                  95      


Asp Val Ala Pro Leu Gly Lys Ile Pro His Leu Arg Thr Pro Gly Leu 
            100                 105                 110         


Leu Val Met Asp Met Asp Ser Thr Ala Ile Gln Ile Glu Cys Ile Asp 
        115                 120                 125             


Glu Ile Ala Lys Leu Ala Gly Thr Gly Glu Met Val Ala Glu Val Thr 
    130                 135                 140                 


Glu Arg Ala Met Arg Gly Glu Leu Asp Phe Thr Ala Ser Leu Arg Ser 
145                 150                 155                 160 


Arg Val Ala Thr Leu Lys Gly Ala Asp Ala Asn Ile Leu Gln Gln Val 
                165                 170                 175     


Arg Glu Asn Leu Pro Leu Met Pro Gly Leu Thr Gln Leu Val Leu Lys 
            180                 185                 190         


Leu Glu Thr Leu Gly Trp Lys Val Ala Ile Ala Ser Gly Gly Phe Thr 
        195                 200                 205             


Phe Phe Ala Glu Tyr Leu Arg Asp Lys Leu Arg Leu Thr Ala Val Val 
    210                 215                 220                 


Ala Asn Glu Leu Glu Ile Met Asp Gly Lys Phe Thr Gly Asn Val Ile 
225                 230                 235                 240 


Gly Asp Ile Val Asp Ala Gln Tyr Lys Ala Lys Thr Leu Thr Arg Leu 
                245                 250                 255     


Ala Gln Glu Tyr Glu Ile Pro Leu Ala Gln Thr Val Ala Ile Gly Asp 
            260                 265                 270         


Gly Ala Asn Asp Leu Pro Met Ile Lys Ala Ala Gly Leu Gly Ile Ala 
        275                 280                 285             


Tyr His Ala Lys Pro Lys Val Asn Glu Lys Ala Glu Val Thr Ile Arg 
    290                 295                 300                 


His Ala Asp Leu Met Gly Val Phe Cys Ile Leu Ser Gly Ser Leu Asn 
305                 310                 315                 320 


Gln Lys 
        


<210>  8
<211>  362
<212>  PRT
<213>  Escherichia coli

<400>  8

Met Ala Gln Ile Phe Asn Phe Ser Ser Gly Pro Ala Met Leu Pro Ala 
1               5                   10                  15      


Glu Val Leu Lys Gln Ala Gln Gln Glu Leu Arg Asp Trp Asn Gly Leu 
            20                  25                  30          


Gly Thr Ser Val Met Glu Val Ser His Arg Gly Lys Glu Phe Ile Gln 
        35                  40                  45              


Val Ala Glu Glu Ala Glu Lys Asp Phe Arg Asp Leu Leu Asn Val Pro 
    50                  55                  60                  


Ser Asn Tyr Lys Val Leu Phe Cys His Gly Gly Gly Arg Gly Gln Phe 
65                  70                  75                  80  


Ala Ala Val Pro Leu Asn Ile Leu Gly Asp Lys Thr Thr Ala Asp Tyr 
                85                  90                  95      


Val Asp Ala Gly Tyr Trp Ala Ala Ser Ala Ile Lys Glu Ala Lys Lys 
            100                 105                 110         


Tyr Cys Thr Pro Asn Val Phe Asp Ala Lys Val Thr Val Asp Gly Leu 
        115                 120                 125             


Arg Ala Val Lys Pro Met Arg Glu Trp Gln Leu Ser Asp Asn Ala Ala 
    130                 135                 140                 


Tyr Met His Tyr Cys Pro Asn Glu Thr Ile Asp Gly Ile Ala Ile Asp 
145                 150                 155                 160 


Glu Thr Pro Asp Phe Gly Ala Asp Val Val Val Ala Ala Asp Phe Ser 
                165                 170                 175     


Ser Thr Ile Leu Ser Arg Pro Ile Asp Val Ser Arg Tyr Gly Val Ile 
            180                 185                 190         


Tyr Ala Gly Ala Gln Lys Asn Ile Gly Pro Ala Gly Leu Thr Ile Val 
        195                 200                 205             


Ile Val Arg Glu Asp Leu Leu Gly Lys Ala Asn Ile Ala Cys Pro Ser 
    210                 215                 220                 


Ile Leu Asp Tyr Ser Ile Leu Asn Asp Asn Gly Ser Met Phe Asn Thr 
225                 230                 235                 240 


Pro Pro Thr Phe Ala Trp Tyr Leu Ser Gly Leu Val Phe Lys Trp Leu 
                245                 250                 255     


Lys Ala Asn Gly Gly Val Ala Glu Met Asp Lys Ile Asn Gln Gln Lys 
            260                 265                 270         


Ala Glu Leu Leu Tyr Gly Val Ile Asp Asn Ser Asp Phe Tyr Arg Asn 
        275                 280                 285             


Asp Val Ala Lys Ala Asn Arg Ser Arg Met Asn Val Pro Phe Gln Leu 
    290                 295                 300                 


Ala Asp Ser Ala Leu Asp Lys Leu Phe Leu Glu Glu Ser Phe Ala Ala 
305                 310                 315                 320 


Gly Leu His Ala Leu Lys Gly His Arg Val Val Gly Gly Met Arg Ala 
                325                 330                 335     


Ser Ile Tyr Asn Ala Met Pro Leu Glu Gly Val Lys Ala Leu Thr Asp 
            340                 345                 350         


Phe Met Val Glu Phe Glu Arg Arg His Gly 
        355                 360         


<210>  9
<211>  299
<212>  PRT
<213>  Escherichia coli

<400>  9

Met Ser Arg Lys Asp Gly Val Leu Ala Leu Leu Val Val Val Val Trp 
1               5                   10                  15      


Gly Leu Asn Phe Val Val Ile Lys Val Gly Leu His Asn Met Pro Pro 
            20                  25                  30          


Leu Met Leu Ala Gly Leu Arg Phe Met Leu Val Ala Phe Pro Ala Ile 
        35                  40                  45              


Phe Phe Val Ala Arg Pro Lys Val Pro Leu Asn Leu Leu Leu Gly Tyr 
    50                  55                  60                  


Gly Leu Thr Ile Ser Phe Ala Gln Phe Ala Phe Leu Phe Cys Ala Ile 
65                  70                  75                  80  


Asn Phe Gly Met Pro Ala Gly Leu Ala Ser Leu Val Leu Gln Ala Gln 
                85                  90                  95      


Ala Phe Phe Thr Ile Met Leu Gly Ala Phe Thr Phe Gly Glu Arg Leu 
            100                 105                 110         


His Gly Lys Gln Leu Ala Gly Ile Ala Leu Ala Ile Phe Gly Val Leu 
        115                 120                 125             


Val Leu Ile Glu Asp Ser Leu Asn Gly Gln His Val Ala Met Leu Gly 
    130                 135                 140                 


Phe Met Leu Thr Leu Ala Ala Ala Phe Ser Trp Ala Cys Gly Asn Ile 
145                 150                 155                 160 


Phe Asn Lys Lys Ile Met Ser His Ser Thr Arg Pro Ala Val Met Ser 
                165                 170                 175     


Leu Val Ile Trp Ser Ala Leu Ile Pro Ile Ile Pro Phe Phe Val Ala 
            180                 185                 190         


Ser Leu Ile Leu Asp Gly Ser Ala Thr Met Ile His Ser Leu Val Thr 
        195                 200                 205             


Ile Asp Met Thr Thr Ile Leu Ser Leu Met Tyr Leu Ala Phe Val Ala 
    210                 215                 220                 


Thr Ile Val Gly Tyr Gly Ile Trp Gly Thr Leu Leu Gly Arg Tyr Glu 
225                 230                 235                 240 


Thr Trp Arg Val Ala Pro Leu Ser Leu Leu Val Pro Val Val Gly Leu 
                245                 250                 255     


Ala Ser Ala Ala Leu Leu Leu Asp Glu Arg Leu Thr Gly Leu Gln Phe 
            260                 265                 270         


Leu Gly Ala Val Leu Ile Met Thr Gly Leu Tyr Ile Asn Val Phe Gly 
        275                 280                 285             


Leu Arg Trp Arg Lys Ala Val Lys Val Gly Ser 
    290                 295                 


<210>  10
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YdeD containing His-tag at C-terminus

<400>  10

Met Ser Arg Lys Asp Gly Val Leu Ala Leu Leu Val Val Val Val Trp 
1               5                   10                  15      


Gly Leu Asn Phe Val Val Ile Lys Val Gly Leu His Asn Met Pro Pro 
            20                  25                  30          


Leu Met Leu Ala Gly Leu Arg Phe Met Leu Val Ala Phe Pro Ala Ile 
        35                  40                  45              


Phe Phe Val Ala Arg Pro Lys Val Pro Leu Asn Leu Leu Leu Gly Tyr 
    50                  55                  60                  


Gly Leu Thr Ile Ser Phe Ala Gln Phe Ala Phe Leu Phe Cys Ala Ile 
65                  70                  75                  80  


Asn Phe Gly Met Pro Ala Gly Leu Ala Ser Leu Val Leu Gln Ala Gln 
                85                  90                  95      


Ala Phe Phe Thr Ile Met Leu Gly Ala Phe Thr Phe Gly Glu Arg Leu 
            100                 105                 110         


His Gly Lys Gln Leu Ala Gly Ile Ala Leu Ala Ile Phe Gly Val Leu 
        115                 120                 125             


Val Leu Ile Glu Asp Ser Leu Asn Gly Gln His Val Ala Met Leu Gly 
    130                 135                 140                 


Phe Met Leu Thr Leu Ala Ala Ala Phe Ser Trp Ala Cys Gly Asn Ile 
145                 150                 155                 160 


Phe Asn Lys Lys Ile Met Ser His Ser Thr Arg Pro Ala Val Met Ser 
                165                 170                 175     


Leu Val Ile Trp Ser Ala Leu Ile Pro Ile Ile Pro Phe Phe Val Ala 
            180                 185                 190         


Ser Leu Ile Leu Asp Gly Ser Ala Thr Met Ile His Ser Leu Val Thr 
        195                 200                 205             


Ile Asp Met Thr Thr Ile Leu Ser Leu Met Tyr Leu Ala Phe Val Ala 
    210                 215                 220                 


Thr Ile Val Gly Tyr Gly Ile Trp Gly Thr Leu Leu Gly Arg Tyr Glu 
225                 230                 235                 240 


Thr Trp Arg Val Ala Pro Leu Ser Leu Leu Val Pro Val Val Gly Leu 
                245                 250                 255     


Ala Ser Ala Ala Leu Leu Leu Asp Glu Arg Leu Thr Gly Leu Gln Phe 
            260                 265                 270         


Leu Gly Ala Val Leu Ile Met Thr Gly Leu Tyr Ile Asn Val Phe Gly 
        275                 280                 285             


Leu Arg Trp Arg Lys Ala Val Lys Val Gly Ser His His His His His 
    290                 295                 300                 


His 
305 


<210>  11
<211>  820
<212>  PRT
<213>  Escherichia coli

<400>  11

Met Arg Val Leu Lys Phe Gly Gly Thr Ser Val Ala Asn Ala Glu Arg 
1               5                   10                  15      


Phe Leu Arg Val Ala Asp Ile Leu Glu Ser Asn Ala Arg Gln Gly Gln 
            20                  25                  30          


Val Ala Thr Val Leu Ser Ala Pro Ala Lys Ile Thr Asn His Leu Val 
        35                  40                  45              


Ala Met Ile Glu Lys Thr Ile Ser Gly Gln Asp Ala Leu Pro Asn Ile 
    50                  55                  60                  


Ser Asp Ala Glu Arg Ile Phe Ala Glu Leu Leu Thr Gly Leu Ala Ala 
65                  70                  75                  80  


Ala Gln Pro Gly Phe Pro Leu Ala Gln Leu Lys Thr Phe Val Asp Gln 
                85                  90                  95      


Glu Phe Ala Gln Ile Lys His Val Leu His Gly Ile Ser Leu Leu Gly 
            100                 105                 110         


Gln Cys Pro Asp Ser Ile Asn Ala Ala Leu Ile Cys Arg Gly Glu Lys 
        115                 120                 125             


Met Ser Ile Ala Ile Met Ala Gly Val Leu Glu Ala Arg Gly His Asn 
    130                 135                 140                 


Val Thr Val Ile Asp Pro Val Glu Lys Leu Leu Ala Val Gly His Tyr 
145                 150                 155                 160 


Leu Glu Ser Thr Val Asp Ile Ala Glu Ser Thr Arg Arg Ile Ala Ala 
                165                 170                 175     


Ser Arg Ile Pro Ala Asp His Met Val Leu Met Ala Gly Phe Thr Ala 
            180                 185                 190         


Gly Asn Glu Lys Gly Glu Leu Val Val Leu Gly Arg Asn Gly Ser Asp 
        195                 200                 205             


Tyr Ser Ala Ala Val Leu Ala Ala Cys Leu Arg Ala Asp Cys Cys Glu 
    210                 215                 220                 


Ile Trp Thr Asp Val Asp Gly Val Tyr Thr Cys Asp Pro Arg Gln Val 
225                 230                 235                 240 


Pro Asp Ala Arg Leu Leu Lys Ser Met Ser Tyr Gln Glu Ala Met Glu 
                245                 250                 255     


Leu Ser Tyr Phe Gly Ala Lys Val Leu His Pro Arg Thr Ile Thr Pro 
            260                 265                 270         


Ile Ala Gln Phe Gln Ile Pro Cys Leu Ile Lys Asn Thr Gly Asn Pro 
        275                 280                 285             


Gln Ala Pro Gly Thr Leu Ile Gly Ala Ser Arg Asp Glu Asp Glu Leu 
    290                 295                 300                 


Pro Val Lys Gly Ile Ser Asn Leu Asn Asn Met Ala Met Phe Ser Val 
305                 310                 315                 320 


Ser Gly Pro Gly Met Lys Gly Met Val Gly Met Ala Ala Arg Val Phe 
                325                 330                 335     


Ala Ala Met Ser Arg Ala Arg Ile Ser Val Val Leu Ile Thr Gln Ser 
            340                 345                 350         


Ser Ser Glu Tyr Ser Ile Ser Phe Cys Val Pro Gln Ser Asp Cys Val 
        355                 360                 365             


Arg Ala Glu Arg Ala Met Gln Glu Glu Phe Tyr Leu Glu Leu Lys Glu 
    370                 375                 380                 


Gly Leu Leu Glu Pro Leu Ala Val Thr Glu Arg Leu Ala Ile Ile Ser 
385                 390                 395                 400 


Val Val Gly Asp Gly Met Arg Thr Leu Arg Gly Ile Ser Ala Lys Phe 
                405                 410                 415     


Phe Ala Ala Leu Ala Arg Ala Asn Ile Asn Ile Val Ala Ile Ala Gln 
            420                 425                 430         


Gly Ser Ser Glu Arg Ser Ile Ser Val Val Val Asn Asn Asp Asp Ala 
        435                 440                 445             


Thr Thr Gly Val Arg Val Thr His Gln Met Leu Phe Asn Thr Asp Gln 
    450                 455                 460                 


Val Ile Glu Val Phe Val Ile Gly Val Gly Gly Val Gly Gly Ala Leu 
465                 470                 475                 480 


Leu Glu Gln Leu Lys Arg Gln Gln Ser Trp Leu Lys Asn Lys His Ile 
                485                 490                 495     


Asp Leu Arg Val Cys Gly Val Ala Asn Ser Lys Ala Leu Leu Thr Asn 
            500                 505                 510         


Val His Gly Leu Asn Leu Glu Asn Trp Gln Glu Glu Leu Ala Gln Ala 
        515                 520                 525             


Lys Glu Pro Phe Asn Leu Gly Arg Leu Ile Arg Leu Val Lys Glu Tyr 
    530                 535                 540                 


His Leu Leu Asn Pro Val Ile Val Asp Cys Thr Ser Ser Gln Ala Val 
545                 550                 555                 560 


Ala Asp Gln Tyr Ala Asp Phe Leu Arg Glu Gly Phe His Val Val Thr 
                565                 570                 575     


Pro Asn Lys Lys Ala Asn Thr Ser Ser Met Asp Tyr Tyr His Gln Leu 
            580                 585                 590         


Arg Tyr Ala Ala Glu Lys Ser Arg Arg Lys Phe Leu Tyr Asp Thr Asn 
        595                 600                 605             


Val Gly Ala Gly Leu Pro Val Ile Glu Asn Leu Gln Asn Leu Leu Asn 
    610                 615                 620                 


Ala Gly Asp Glu Leu Met Lys Phe Ser Gly Ile Leu Ser Gly Ser Leu 
625                 630                 635                 640 


Ser Tyr Ile Phe Gly Lys Leu Asp Glu Gly Met Ser Phe Ser Glu Ala 
                645                 650                 655     


Thr Thr Leu Ala Arg Glu Met Gly Tyr Thr Glu Pro Asp Pro Arg Asp 
            660                 665                 670         


Asp Leu Ser Gly Met Asp Val Ala Arg Lys Leu Leu Ile Leu Ala Arg 
        675                 680                 685             


Glu Thr Gly Arg Glu Leu Glu Leu Ala Asp Ile Glu Ile Glu Pro Val 
    690                 695                 700                 


Leu Pro Ala Glu Phe Asn Ala Glu Gly Asp Val Ala Ala Phe Met Ala 
705                 710                 715                 720 


Asn Leu Ser Gln Leu Asp Asp Leu Phe Ala Ala Arg Val Ala Lys Ala 
                725                 730                 735     


Arg Asp Glu Gly Lys Val Leu Arg Tyr Val Gly Asn Ile Asp Glu Asp 
            740                 745                 750         


Gly Val Cys Arg Val Lys Ile Ala Glu Val Asp Gly Asn Asp Pro Leu 
        755                 760                 765             


Phe Lys Val Lys Asn Gly Glu Asn Ala Leu Ala Phe Tyr Ser His Tyr 
    770                 775                 780                 


Tyr Gln Pro Leu Pro Leu Val Leu Arg Gly Tyr Gly Ala Gly Asn Asp 
785                 790                 795                 800 


Val Thr Ala Ala Gly Val Phe Ala Asp Leu Leu Arg Thr Leu Ser Trp 
                805                 810                 815     


Lys Leu Gly Val 
            820 


<210>  12
<211>  164
<212>  PRT
<213>  Escherichia coli

<400>  12

Met Val Asp Ser Lys Lys Arg Pro Gly Lys Asp Leu Asp Arg Ile Asp 
1               5                   10                  15      


Arg Asn Ile Leu Asn Glu Leu Gln Lys Asp Gly Arg Ile Ser Asn Val 
            20                  25                  30          


Glu Leu Ser Lys Arg Val Gly Leu Ser Pro Thr Pro Cys Leu Glu Arg 
        35                  40                  45              


Val Arg Arg Leu Glu Arg Gln Gly Phe Ile Gln Gly Tyr Thr Ala Leu 
    50                  55                  60                  


Leu Asn Pro His Tyr Leu Asp Ala Ser Leu Leu Val Phe Val Glu Ile 
65                  70                  75                  80  


Thr Leu Asn Arg Gly Ala Pro Asp Val Phe Glu Gln Phe Asn Thr Ala 
                85                  90                  95      


Val Gln Lys Leu Glu Glu Ile Gln Glu Cys His Leu Val Ser Gly Asp 
            100                 105                 110         


Phe Asp Tyr Leu Leu Lys Thr Arg Val Pro Asp Met Ser Ala Tyr Arg 
        115                 120                 125             


Lys Leu Leu Gly Glu Thr Leu Leu Arg Leu Pro Gly Val Asn Asp Thr 
    130                 135                 140                 


Arg Thr Tyr Val Val Met Glu Glu Val Lys Gln Ser Asn Arg Leu Val 
145                 150                 155                 160 


Ile Lys Thr Arg 
                


<210>  13
<211>  419
<212>  PRT
<213>  Escherichia coli

<400>  13

Met Asn Leu Thr Glu Leu Lys Asn Thr Pro Val Ser Glu Leu Ile Thr 
1               5                   10                  15      


Leu Gly Glu Asn Met Gly Leu Glu Asn Leu Ala Arg Met Arg Lys Gln 
            20                  25                  30          


Asp Ile Ile Phe Ala Ile Leu Lys Gln His Ala Lys Ser Gly Glu Asp 
        35                  40                  45              


Ile Phe Gly Asp Gly Val Leu Glu Ile Leu Gln Asp Gly Phe Gly Phe 
    50                  55                  60                  


Leu Arg Ser Ala Asp Ser Ser Tyr Leu Ala Gly Pro Asp Asp Ile Tyr 
65                  70                  75                  80  


Val Ser Pro Ser Gln Ile Arg Arg Phe Asn Leu Arg Thr Gly Asp Thr 
                85                  90                  95      


Ile Ser Gly Lys Ile Arg Pro Pro Lys Glu Gly Glu Arg Tyr Phe Ala 
            100                 105                 110         


Leu Leu Lys Val Asn Glu Val Asn Phe Asp Lys Pro Glu Asn Ala Arg 
        115                 120                 125             


Asn Lys Ile Leu Phe Glu Asn Leu Thr Pro Leu His Ala Asn Ser Arg 
    130                 135                 140                 


Leu Arg Met Glu Arg Gly Asn Gly Ser Thr Glu Asp Leu Thr Ala Arg 
145                 150                 155                 160 


Val Leu Asp Leu Ala Ser Pro Ile Gly Arg Gly Gln Arg Gly Leu Ile 
                165                 170                 175     


Val Ala Pro Pro Lys Ala Gly Lys Thr Met Leu Leu Gln Asn Ile Ala 
            180                 185                 190         


Gln Ser Ile Ala Tyr Asn His Pro Asp Cys Val Leu Met Val Leu Leu 
        195                 200                 205             


Ile Asp Glu Arg Pro Glu Glu Val Thr Glu Met Gln Arg Leu Val Lys 
    210                 215                 220                 


Gly Glu Val Val Ala Ser Thr Phe Asp Glu Pro Ala Ser Arg His Val 
225                 230                 235                 240 


Gln Val Ala Glu Met Val Ile Glu Lys Ala Lys Arg Leu Val Glu His 
                245                 250                 255     


Lys Lys Asp Val Ile Ile Leu Leu Asp Ser Ile Thr Arg Leu Ala Arg 
            260                 265                 270         


Ala Tyr Asn Thr Val Val Pro Ala Ser Gly Lys Val Leu Thr Gly Gly 
        275                 280                 285             


Val Asp Ala Asn Ala Leu His Arg Pro Lys Arg Phe Phe Gly Ala Ala 
    290                 295                 300                 


Arg Asn Val Glu Glu Gly Gly Ser Leu Thr Ile Ile Ala Thr Ala Leu 
305                 310                 315                 320 


Ile Asp Thr Gly Ser Lys Met Asp Glu Val Ile Tyr Glu Glu Phe Lys 
                325                 330                 335     


Gly Thr Gly Asn Met Glu Leu His Leu Ser Arg Lys Ile Ala Glu Lys 
            340                 345                 350         


Arg Val Phe Pro Ala Ile Asp Tyr Asn Arg Ser Gly Thr Arg Lys Glu 
        355                 360                 365             


Glu Leu Leu Thr Thr Gln Glu Glu Leu Gln Lys Met Trp Ile Leu Arg 
    370                 375                 380                 


Lys Ile Ile His Pro Met Gly Glu Ile Asp Ala Met Glu Phe Leu Ile 
385                 390                 395                 400 


Asn Lys Leu Ala Met Thr Lys Thr Asn Asp Asp Phe Phe Glu Met Met 
                405                 410                 415     


Lys Arg Ser 
            


<210>  14
<211>  432
<212>  PRT
<213>  Escherichia coli

<400>  14

Met Ser Lys Ile Val Lys Ile Ile Gly Arg Glu Ile Ile Asp Ser Arg 
1               5                   10                  15      


Gly Asn Pro Thr Val Glu Ala Glu Val His Leu Glu Gly Gly Phe Val 
            20                  25                  30          


Gly Met Ala Ala Ala Pro Ser Gly Ala Ser Thr Gly Ser Arg Glu Ala 
        35                  40                  45              


Leu Glu Leu Arg Asp Gly Asp Lys Ser Arg Phe Leu Gly Lys Gly Val 
    50                  55                  60                  


Thr Lys Ala Val Ala Ala Val Asn Gly Pro Ile Ala Gln Ala Leu Ile 
65                  70                  75                  80  


Gly Lys Asp Ala Lys Asp Gln Ala Gly Ile Asp Lys Ile Met Ile Asp 
                85                  90                  95      


Leu Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Ala Val Ser Leu Ala Asn Ala Lys Ala Ala Ala Ala Ala Lys Gly Met 
        115                 120                 125             


Pro Leu Tyr Glu His Ile Ala Glu Leu Asn Gly Thr Pro Gly Lys Tyr 
    130                 135                 140                 


Ser Met Pro Val Pro Met Met Asn Ile Ile Asn Gly Gly Glu His Ala 
145                 150                 155                 160 


Asp Asn Asn Val Asp Ile Gln Glu Phe Met Ile Gln Pro Val Gly Ala 
                165                 170                 175     


Lys Thr Val Lys Glu Ala Ile Arg Met Gly Ser Glu Val Phe His His 
            180                 185                 190         


Leu Ala Lys Val Leu Lys Ala Lys Gly Met Asn Thr Ala Val Gly Asp 
        195                 200                 205             


Glu Gly Gly Tyr Ala Pro Asn Leu Gly Ser Asn Ala Glu Ala Leu Ala 
    210                 215                 220                 


Val Ile Ala Glu Ala Val Lys Ala Ala Gly Tyr Glu Leu Gly Lys Asp 
225                 230                 235                 240 


Ile Thr Leu Ala Met Asp Cys Ala Ala Ser Glu Phe Tyr Lys Asp Gly 
                245                 250                 255     


Lys Tyr Val Leu Ala Gly Glu Gly Asn Lys Ala Phe Thr Ser Glu Glu 
            260                 265                 270         


Phe Thr His Phe Leu Glu Glu Leu Thr Lys Gln Tyr Pro Ile Val Ser 
        275                 280                 285             


Ile Glu Asp Gly Leu Asp Glu Ser Asp Trp Asp Gly Phe Ala Tyr Gln 
    290                 295                 300                 


Thr Lys Val Leu Gly Asp Lys Ile Gln Leu Val Gly Asp Asp Leu Phe 
305                 310                 315                 320 


Val Thr Asn Thr Lys Ile Leu Lys Glu Gly Ile Glu Lys Gly Ile Ala 
                325                 330                 335     


Asn Ser Ile Leu Ile Lys Phe Asn Gln Ile Gly Ser Leu Thr Glu Thr 
            340                 345                 350         


Leu Ala Ala Ile Lys Met Ala Lys Asp Ala Gly Tyr Thr Ala Val Ile 
        355                 360                 365             


Ser His Arg Ser Gly Glu Thr Glu Asp Ala Thr Ile Ala Asp Leu Ala 
    370                 375                 380                 


Val Gly Thr Ala Ala Gly Gln Ile Lys Thr Gly Ser Met Ser Arg Ser 
385                 390                 395                 400 


Asp Arg Val Ala Lys Tyr Asn Gln Leu Ile Arg Ile Glu Glu Ala Leu 
                405                 410                 415     


Gly Glu Lys Ala Pro Tyr Asn Gly Arg Lys Glu Ile Lys Gly Gln Ala 
            420                 425                 430         


<210>  15
<211>  297
<212>  PRT
<213>  Escherichia coli

<400>  15

Met Lys Arg Pro Asp Tyr Arg Thr Leu Gln Ala Leu Asp Ala Val Ile 
1               5                   10                  15      


Arg Glu Arg Gly Phe Glu Arg Ala Ala Gln Lys Leu Cys Ile Thr Gln 
            20                  25                  30          


Ser Ala Val Ser Gln Arg Ile Lys Gln Leu Glu Asn Met Phe Gly Gln 
        35                  40                  45              


Pro Leu Leu Val Arg Thr Val Pro Pro Arg Pro Thr Glu Gln Gly Gln 
    50                  55                  60                  


Lys Leu Leu Ala Leu Leu Arg Gln Val Glu Leu Leu Glu Glu Glu Trp 
65                  70                  75                  80  


Leu Gly Asp Glu Gln Thr Gly Ser Thr Pro Leu Leu Leu Ser Leu Ala 
                85                  90                  95      


Val Asn Ala Asp Ser Leu Ala Thr Trp Leu Leu Pro Ala Leu Ala Pro 
            100                 105                 110         


Val Leu Ala Asp Ser Pro Ile Arg Leu Asn Leu Gln Val Glu Asp Glu 
        115                 120                 125             


Thr Arg Thr Gln Glu Arg Leu Arg Arg Gly Glu Val Val Gly Ala Val 
    130                 135                 140                 


Ser Ile Gln His Gln Ala Leu Pro Ser Cys Leu Val Asp Lys Leu Gly 
145                 150                 155                 160 


Ala Leu Asp Tyr Leu Phe Val Ser Ser Lys Pro Phe Ala Glu Lys Tyr 
                165                 170                 175     


Phe Pro Asn Gly Val Thr Arg Ser Ala Leu Leu Lys Ala Pro Val Val 
            180                 185                 190         


Ala Phe Asp His Leu Asp Asp Met His Gln Ala Phe Leu Gln Gln Asn 
        195                 200                 205             


Phe Asp Leu Pro Pro Gly Ser Val Pro Cys His Ile Val Asn Ser Ser 
    210                 215                 220                 


Glu Ala Phe Val Gln Leu Ala Arg Gln Gly Thr Thr Cys Cys Met Ile 
225                 230                 235                 240 


Pro His Leu Gln Ile Glu Lys Glu Leu Ala Ser Gly Glu Leu Ile Asp 
                245                 250                 255     


Leu Thr Pro Gly Leu Phe Gln Arg Arg Met Leu Tyr Trp His Arg Phe 
            260                 265                 270         


Ala Pro Glu Ser Arg Met Met Arg Lys Val Thr Asp Ala Leu Leu Asp 
        275                 280                 285             


Tyr Gly His Lys Val Leu Arg Gln Asp 
    290                 295         


<210>  16
<211>  394
<212>  PRT
<213>  Escherichia coli

<400>  16

Met Ser Lys Glu Lys Phe Glu Arg Thr Lys Pro His Val Asn Val Gly 
1               5                   10                  15      


Thr Ile Gly His Val Asp His Gly Lys Thr Thr Leu Thr Ala Ala Ile 
            20                  25                  30          


Thr Thr Val Leu Ala Lys Thr Tyr Gly Gly Ala Ala Arg Ala Phe Asp 
        35                  40                  45              


Gln Ile Asp Asn Ala Pro Glu Glu Lys Ala Arg Gly Ile Thr Ile Asn 
    50                  55                  60                  


Thr Ser His Val Glu Tyr Asp Thr Pro Thr Arg His Tyr Ala His Val 
65                  70                  75                  80  


Asp Cys Pro Gly His Ala Asp Tyr Val Lys Asn Met Ile Thr Gly Ala 
                85                  90                  95      


Ala Gln Met Asp Gly Ala Ile Leu Val Val Ala Ala Thr Asp Gly Pro 
            100                 105                 110         


Met Pro Gln Thr Arg Glu His Ile Leu Leu Gly Arg Gln Val Gly Val 
        115                 120                 125             


Pro Tyr Ile Ile Val Phe Leu Asn Lys Cys Asp Met Val Asp Asp Glu 
    130                 135                 140                 


Glu Leu Leu Glu Leu Val Glu Met Glu Val Arg Glu Leu Leu Ser Gln 
145                 150                 155                 160 


Tyr Asp Phe Pro Gly Asp Asp Thr Pro Ile Val Arg Gly Ser Ala Leu 
                165                 170                 175     


Lys Ala Leu Glu Gly Asp Ala Glu Trp Glu Ala Lys Ile Leu Glu Leu 
            180                 185                 190         


Ala Gly Phe Leu Asp Ser Tyr Ile Pro Glu Pro Glu Arg Ala Ile Asp 
        195                 200                 205             


Lys Pro Phe Leu Leu Pro Ile Glu Asp Val Phe Ser Ile Ser Gly Arg 
    210                 215                 220                 


Gly Thr Val Val Thr Gly Arg Val Glu Arg Gly Ile Ile Lys Val Gly 
225                 230                 235                 240 


Glu Glu Val Glu Ile Val Gly Ile Lys Glu Thr Gln Lys Ser Thr Cys 
                245                 250                 255     


Thr Gly Val Glu Met Phe Arg Lys Leu Leu Asp Glu Gly Arg Ala Gly 
            260                 265                 270         


Glu Asn Val Gly Val Leu Leu Arg Gly Ile Lys Arg Glu Glu Ile Glu 
        275                 280                 285             


Arg Gly Gln Val Leu Ala Lys Pro Gly Thr Ile Lys Pro His Thr Lys 
    290                 295                 300                 


Phe Glu Ser Glu Val Tyr Ile Leu Ser Lys Asp Glu Gly Gly Arg His 
305                 310                 315                 320 


Thr Pro Phe Phe Lys Gly Tyr Arg Pro Gln Phe Tyr Phe Arg Thr Thr 
                325                 330                 335     


Asp Val Thr Gly Thr Ile Glu Leu Pro Glu Gly Val Glu Met Val Met 
            340                 345                 350         


Pro Gly Asp Asn Ile Lys Met Val Val Thr Leu Ile His Pro Ile Ala 
        355                 360                 365             


Met Asp Asp Gly Leu Arg Phe Ala Ile Arg Glu Gly Gly Arg Thr Val 
    370                 375                 380                 


Gly Ala Gly Val Val Ala Lys Val Leu Gly 
385                 390                 


<210>  17
<211>  470
<212>  PRT
<213>  Escherichia coli

<400>  17

Met Val Asp Gln Val Lys Val Val Ala Asp Asp Gln Ala Pro Ala Glu 
1               5                   10                  15      


Gln Ser Leu Arg Arg Asn Leu Thr Asn Arg His Ile Gln Leu Ile Ala 
            20                  25                  30          


Ile Gly Gly Ala Ile Gly Thr Gly Leu Phe Met Gly Ser Gly Lys Thr 
        35                  40                  45              


Ile Ser Leu Ala Gly Pro Ser Ile Ile Phe Val Tyr Met Ile Ile Gly 
    50                  55                  60                  


Phe Met Leu Phe Phe Val Met Arg Ala Met Gly Glu Leu Leu Leu Ser 
65                  70                  75                  80  


Asn Leu Glu Tyr Lys Ser Phe Ser Asp Phe Ala Ser Asp Leu Leu Gly 
                85                  90                  95      


Pro Trp Ala Gly Tyr Phe Thr Gly Trp Thr Tyr Trp Phe Cys Trp Val 
            100                 105                 110         


Val Thr Gly Met Ala Asp Val Val Ala Ile Thr Ala Tyr Ala Gln Phe 
        115                 120                 125             


Trp Phe Pro Asp Leu Ser Asp Trp Val Ala Ser Leu Ala Val Ile Val 
    130                 135                 140                 


Leu Leu Leu Thr Leu Asn Leu Ala Thr Val Lys Met Phe Gly Glu Met 
145                 150                 155                 160 


Glu Phe Trp Phe Ala Met Ile Lys Ile Val Ala Ile Val Ser Leu Ile 
                165                 170                 175     


Val Val Gly Leu Val Met Val Ala Met His Phe Gln Ser Pro Thr Gly 
            180                 185                 190         


Val Glu Ala Ser Phe Ala His Leu Trp Asn Asp Gly Gly Trp Phe Pro 
        195                 200                 205             


Lys Gly Leu Ser Gly Phe Phe Ala Gly Phe Gln Ile Ala Val Phe Ala 
    210                 215                 220                 


Phe Val Gly Ile Glu Leu Val Gly Thr Thr Ala Ala Glu Thr Lys Asp 
225                 230                 235                 240 


Pro Glu Lys Ser Leu Pro Arg Ala Ile Asn Ser Ile Pro Ile Arg Ile 
                245                 250                 255     


Ile Met Phe Tyr Val Phe Ala Leu Ile Val Ile Met Ser Val Thr Pro 
            260                 265                 270         


Trp Ser Ser Val Val Pro Glu Lys Ser Pro Phe Val Glu Leu Phe Val 
        275                 280                 285             


Leu Val Gly Leu Pro Ala Ala Ala Ser Val Ile Asn Phe Val Val Leu 
    290                 295                 300                 


Thr Ser Ala Ala Ser Ser Ala Asn Ser Gly Val Phe Ser Thr Ser Arg 
305                 310                 315                 320 


Met Leu Phe Gly Leu Ala Gln Glu Gly Val Ala Pro Lys Ala Phe Ala 
                325                 330                 335     


Lys Leu Ser Lys Arg Ala Val Pro Ala Lys Gly Leu Thr Phe Ser Cys 
            340                 345                 350         


Ile Cys Leu Leu Gly Gly Val Val Met Leu Tyr Val Asn Pro Ser Val 
        355                 360                 365             


Ile Gly Ala Phe Thr Met Ile Thr Thr Val Ser Ala Ile Leu Phe Met 
    370                 375                 380                 


Phe Val Trp Thr Ile Ile Leu Cys Ser Tyr Leu Val Tyr Arg Lys Gln 
385                 390                 395                 400 


Arg Pro His Leu His Glu Lys Ser Ile Tyr Lys Met Pro Leu Gly Lys 
                405                 410                 415     


Leu Met Cys Trp Val Cys Met Ala Phe Phe Val Phe Val Val Val Leu 
            420                 425                 430         


Leu Thr Leu Glu Asp Asp Thr Arg Gln Ala Leu Leu Val Thr Pro Leu 
        435                 440                 445             


Trp Phe Ile Ala Leu Gly Leu Gly Trp Leu Phe Ile Gly Lys Lys Arg 
    450                 455                 460                 


Ala Ala Glu Leu Arg Lys 
465                 470 


<210>  18
<211>  225
<212>  PRT
<213>  Escherichia coli

<400>  18

Met Lys Gln Tyr Leu Ile Ala Pro Ser Ile Leu Ser Ala Asp Phe Ala 
1               5                   10                  15      


Arg Leu Gly Glu Asp Thr Ala Lys Ala Leu Ala Ala Gly Ala Asp Val 
            20                  25                  30          


Val His Phe Asp Val Met Asp Asn His Tyr Val Pro Asn Leu Thr Ile 
        35                  40                  45              


Gly Pro Met Val Leu Lys Ser Leu Arg Asn Tyr Gly Ile Thr Ala Pro 
    50                  55                  60                  


Ile Asp Val His Leu Met Val Lys Pro Val Asp Arg Ile Val Pro Asp 
65                  70                  75                  80  


Phe Ala Ala Ala Gly Ala Ser Ile Ile Thr Phe His Pro Glu Ala Ser 
                85                  90                  95      


Glu His Val Asp Arg Thr Leu Gln Leu Ile Lys Glu Asn Gly Cys Lys 
            100                 105                 110         


Ala Gly Leu Val Phe Asn Pro Ala Thr Pro Leu Ser Tyr Leu Asp Tyr 
        115                 120                 125             


Val Met Asp Lys Leu Asp Val Ile Leu Leu Met Ser Val Asn Pro Gly 
    130                 135                 140                 


Phe Gly Gly Gln Ser Phe Ile Pro Gln Thr Leu Asp Lys Leu Arg Glu 
145                 150                 155                 160 


Val Arg Arg Arg Ile Asp Glu Ser Gly Phe Asp Ile Arg Leu Glu Val 
                165                 170                 175     


Asp Gly Gly Val Lys Val Asn Asn Ile Gly Glu Ile Ala Ala Ala Gly 
            180                 185                 190         


Ala Asp Met Phe Val Ala Gly Ser Ala Ile Phe Asp Gln Pro Asp Tyr 
        195                 200                 205             


Lys Lys Val Ile Asp Glu Met Arg Ser Glu Leu Ala Lys Val Ser His 
    210                 215                 220                 


Glu 
225 


<210>  19
<211>  547
<212>  PRT
<213>  Escherichia coli

<400>  19

Met Glu Leu Leu Val Leu Val Trp Arg Gln Tyr Arg Trp Pro Phe Ile 
1               5                   10                  15      


Ser Val Met Ala Leu Ser Leu Ala Ser Ala Ala Leu Gly Ile Gly Leu 
            20                  25                  30          


Ile Ala Phe Ile Asn Gln Arg Leu Ile Glu Thr Ala Asp Thr Ser Leu 
        35                  40                  45              


Leu Val Leu Pro Glu Phe Leu Gly Leu Leu Leu Leu Leu Met Ala Val 
    50                  55                  60                  


Thr Leu Gly Ser Gln Leu Ala Leu Thr Thr Leu Gly His His Phe Val 
65                  70                  75                  80  


Tyr Arg Leu Arg Ser Glu Phe Ile Lys Arg Ile Leu Asp Thr His Val 
                85                  90                  95      


Glu Arg Ile Glu Gln Leu Gly Ser Ala Ser Leu Leu Ala Gly Leu Thr 
            100                 105                 110         


Ser Asp Val Arg Asn Ile Thr Ile Ala Phe Val Arg Leu Pro Glu Leu 
        115                 120                 125             


Val Gln Gly Ile Ile Leu Thr Ile Gly Ser Ala Ala Tyr Leu Trp Met 
    130                 135                 140                 


Leu Ser Gly Lys Met Leu Leu Val Thr Ala Ile Trp Met Ala Ile Thr 
145                 150                 155                 160 


Ile Trp Gly Gly Phe Val Leu Val Ala Arg Val Tyr Lys His Met Ala 
                165                 170                 175     


Thr Leu Arg Glu Thr Glu Asp Lys Leu Tyr Thr Asp Phe Gln Thr Val 
            180                 185                 190         


Leu Glu Gly Arg Lys Glu Leu Thr Leu Asn Arg Glu Arg Ala Glu Tyr 
        195                 200                 205             


Val Phe Asn Asn Leu Tyr Ile Pro Asp Ala Gln Glu Tyr Arg His His 
    210                 215                 220                 


Ile Ile Arg Ala Asp Thr Phe His Leu Ser Ala Val Asn Trp Ser Asn 
225                 230                 235                 240 


Ile Met Met Leu Gly Ala Ile Gly Leu Val Phe Trp Met Ala Asn Ser 
                245                 250                 255     


Leu Gly Trp Ala Asp Thr Asn Val Ala Ala Thr Tyr Ser Leu Thr Leu 
            260                 265                 270         


Leu Phe Leu Arg Thr Pro Leu Leu Ser Ala Val Gly Ala Leu Pro Thr 
        275                 280                 285             


Leu Leu Thr Ala Gln Val Ala Phe Asn Lys Leu Asn Lys Phe Ala Leu 
    290                 295                 300                 


Ala Pro Phe Lys Ala Glu Phe Pro Arg Pro Gln Ala Phe Pro Asn Trp 
305                 310                 315                 320 


Gln Thr Leu Glu Leu Arg Asn Val Thr Phe Ala Tyr Gln Asp Asn Ala 
                325                 330                 335     


Phe Ser Val Gly Pro Ile Asn Leu Thr Ile Lys Arg Gly Glu Leu Leu 
            340                 345                 350         


Phe Leu Ile Gly Gly Asn Gly Ser Gly Lys Ser Thr Leu Ala Met Leu 
        355                 360                 365             


Leu Thr Gly Leu Tyr Gln Pro Gln Ser Gly Glu Ile Leu Leu Asp Gly 
    370                 375                 380                 


Lys Pro Val Ser Gly Glu Gln Pro Glu Asp Tyr Arg Lys Leu Phe Ser 
385                 390                 395                 400 


Ala Val Phe Thr Asp Val Trp Leu Phe Asp Gln Leu Leu Gly Pro Glu 
                405                 410                 415     


Gly Lys Pro Ala Asn Pro Gln Leu Val Glu Lys Trp Leu Ala Gln Leu 
            420                 425                 430         


Lys Met Ala His Lys Leu Glu Leu Ser Asn Gly Arg Ile Val Asn Leu 
        435                 440                 445             


Lys Leu Ser Lys Gly Gln Lys Lys Arg Val Ala Leu Leu Leu Ala Leu 
    450                 455                 460                 


Ala Glu Glu Arg Asp Ile Ile Leu Leu Asp Glu Trp Ala Ala Asp Gln 
465                 470                 475                 480 


Asp Pro His Phe Arg Arg Glu Phe Tyr Gln Val Leu Leu Pro Leu Met 
                485                 490                 495     


Gln Glu Met Gly Lys Thr Ile Phe Ala Ile Ser His Asp Asp His Tyr 
            500                 505                 510         


Phe Ile His Ala Asp Arg Leu Leu Glu Met Arg Asn Gly Gln Leu Ser 
        515                 520                 525             


Glu Leu Thr Gly Glu Glu Arg Asp Ala Ala Ser Arg Asp Ala Val Ala 
    530                 535                 540                 


Arg Thr Ala 
545         


<210>  20
<211>  285
<212>  PRT
<213>  Escherichia coli

<400>  20

Met Ser Glu Thr Phe Phe His Leu Leu Gly Pro Gly Thr Gln Pro Asn 
1               5                   10                  15      


Asp Asp Ser Phe Ser Met Asn Pro Leu Pro Ile Thr Cys Gln Val Asn 
            20                  25                  30          


Asp Glu Pro Ser Met Ala Ala Leu Glu Gln Cys Ala His Ser Pro Gln 
        35                  40                  45              


Val Ile Ala Leu Leu Asn Glu Leu Gln His Gln Leu Ser Glu Arg Gln 
    50                  55                  60                  


Pro Pro Leu Gly Glu Val Leu Ala Val Asp Leu Leu Asn Leu Asn Ala 
65                  70                  75                  80  


Asp Asp Arg His Phe Ile Asn Thr Leu Leu Gly Glu Gly Glu Val Ser 
                85                  90                  95      


Val Arg Ile Gln Gln Ala Asp Asp Ser Glu Ser Glu Ile Gln Glu Ala 
            100                 105                 110         


Ile Phe Cys Gly Leu Trp Arg Val Arg Arg Arg Arg Gly Glu Lys Leu 
        115                 120                 125             


Leu Glu Asp Lys Leu Glu Ala Gly Cys Ala Pro Leu Ala Leu Trp Gln 
    130                 135                 140                 


Ala Ala Thr Gln Asn Leu Leu Pro Thr Asp Ser Leu Leu Pro Pro Pro 
145                 150                 155                 160 


Ile Asp Gly Leu Met Asn Gly Leu Pro Leu Ala His Glu Leu Leu Ala 
                165                 170                 175     


His Val Arg Asn Pro Asp Ala Gln Pro His Ser Ile Asn Leu Thr Gln 
            180                 185                 190         


Leu Pro Ile Ser Glu Ala Asp Arg Leu Phe Leu Ser Arg Leu Cys Gly 
        195                 200                 205             


Pro Gly Asn Ile Gln Ile Arg Thr Ile Gly Tyr Gly Glu Ser Tyr Ile 
    210                 215                 220                 


Asn Ala Thr Gly Leu Arg His Val Trp His Leu Arg Cys Thr Asp Thr 
225                 230                 235                 240 


Leu Lys Gly Pro Leu Leu Glu Ser Tyr Glu Ile Cys Pro Ile Pro Glu 
                245                 250                 255     


Val Val Leu Ala Ala Pro Glu Asp Leu Val Asp Ser Ala Gln Arg Leu 
            260                 265                 270         


Ser Glu Val Cys Gln Trp Leu Ala Glu Ala Ala Pro Thr 
        275                 280                 285 


<210>  21
<211>  470
<212>  PRT
<213>  Escherichia coli

<400>  21

Met Lys Lys Thr Lys Ile Val Cys Thr Ile Gly Pro Lys Thr Glu Ser 
1               5                   10                  15      


Glu Glu Met Leu Ala Lys Met Leu Asp Ala Gly Met Asn Val Met Arg 
            20                  25                  30          


Leu Asn Phe Ser His Gly Asp Tyr Ala Glu His Gly Gln Arg Ile Gln 
        35                  40                  45              


Asn Leu Arg Asn Val Met Ser Lys Thr Gly Lys Thr Ala Ala Ile Leu 
    50                  55                  60                  


Leu Asp Thr Lys Gly Pro Glu Ile Arg Thr Met Lys Leu Glu Gly Gly 
65                  70                  75                  80  


Asn Asp Val Ser Leu Lys Ala Gly Gln Thr Phe Thr Phe Thr Thr Asp 
                85                  90                  95      


Lys Ser Val Ile Gly Asn Ser Glu Met Val Ala Val Thr Tyr Glu Gly 
            100                 105                 110         


Phe Thr Thr Asp Leu Ser Val Gly Asn Thr Val Leu Val Asp Asp Gly 
        115                 120                 125             


Leu Ile Gly Met Glu Val Thr Ala Ile Glu Gly Asn Lys Val Ile Cys 
    130                 135                 140                 


Lys Val Leu Asn Asn Gly Asp Leu Gly Glu Asn Lys Gly Val Asn Leu 
145                 150                 155                 160 


Pro Gly Val Ser Ile Ala Leu Pro Ala Leu Ala Glu Lys Asp Lys Gln 
                165                 170                 175     


Asp Leu Ile Phe Gly Cys Glu Gln Gly Val Asp Phe Val Ala Ala Ser 
            180                 185                 190         


Phe Ile Arg Lys Arg Ser Asp Val Ile Glu Ile Arg Glu His Leu Lys 
        195                 200                 205             


Ala His Gly Gly Glu Asn Ile His Ile Ile Ser Lys Ile Glu Asn Gln 
    210                 215                 220                 


Glu Gly Leu Asn Asn Phe Asp Glu Ile Leu Glu Ala Ser Asp Gly Ile 
225                 230                 235                 240 


Met Val Ala Arg Gly Asp Leu Gly Val Glu Ile Pro Val Glu Glu Val 
                245                 250                 255     


Ile Phe Ala Gln Lys Met Met Ile Glu Lys Cys Ile Arg Ala Arg Lys 
            260                 265                 270         


Val Val Ile Thr Ala Thr Gln Met Leu Asp Ser Met Ile Lys Asn Pro 
        275                 280                 285             


Arg Pro Thr Arg Ala Glu Ala Gly Asp Val Ala Asn Ala Ile Leu Asp 
    290                 295                 300                 


Gly Thr Asp Ala Val Met Leu Ser Gly Glu Ser Ala Lys Gly Lys Tyr 
305                 310                 315                 320 


Pro Leu Glu Ala Val Ser Ile Met Ala Thr Ile Cys Glu Arg Thr Asp 
                325                 330                 335     


Arg Val Met Asn Ser Arg Leu Glu Phe Asn Asn Asp Asn Arg Lys Leu 
            340                 345                 350         


Arg Ile Thr Glu Ala Val Cys Arg Gly Ala Val Glu Thr Ala Glu Lys 
        355                 360                 365             


Leu Asp Ala Pro Leu Ile Val Val Ala Thr Gln Gly Gly Lys Ser Ala 
    370                 375                 380                 


Arg Ala Val Arg Lys Tyr Phe Pro Asp Ala Thr Ile Leu Ala Leu Thr 
385                 390                 395                 400 


Thr Asn Glu Lys Thr Ala His Gln Leu Val Leu Ser Lys Gly Val Val 
                405                 410                 415     


Pro Gln Leu Val Lys Glu Ile Thr Ser Thr Asp Asp Phe Tyr Arg Leu 
            420                 425                 430         


Gly Lys Glu Leu Ala Leu Gln Ser Gly Leu Ala His Lys Gly Asp Val 
        435                 440                 445             


Val Val Met Val Ser Gly Ala Leu Val Pro Ser Gly Thr Thr Asn Thr 
    450                 455                 460                 


Ala Ser Val His Val Leu 
465                 470 


<210>  22
<211>  249
<212>  PRT
<213>  Escherichia coli

<400>  22

Met Lys Lys Thr Lys Ile Val Cys Thr Ile Gly Pro Lys Thr Glu Ser 
1               5                   10                  15      


Glu Glu Met Leu Ala Lys Met Leu Asp Ala Gly Met Asn Val Met Arg 
            20                  25                  30          


Leu Asn Phe Ser His Gly Asp Tyr Ala Glu His Gly Gln Arg Ile Gln 
        35                  40                  45              


Asn Leu Arg Asn Val Met Ser Lys Thr Gly Lys Thr Ala Ala Ile Leu 
    50                  55                  60                  


Leu Asp Thr Lys Gly Pro Glu Ile Arg Thr Met Lys Leu Glu Gly Gly 
65                  70                  75                  80  


Asn Asp Val Ser Leu Lys Ala Gly Gln Thr Phe Thr Phe Thr Thr Asp 
                85                  90                  95      


Lys Ser Val Ile Gly Asn Ser Glu Met Val Ala Val Thr Tyr Glu Gly 
            100                 105                 110         


Phe Thr Thr Asp Leu Ser Val Gly Asn Thr Val Leu Val Asp Asp Gly 
        115                 120                 125             


Leu Ile Gly Met Glu Val Thr Ala Ile Glu Gly Asn Lys Val Ile Cys 
    130                 135                 140                 


Lys Val Leu Asn Asn Gly Asp Leu Gly Glu Asn Lys Gly Val Asn Leu 
145                 150                 155                 160 


Pro Gly Val Ser Ile Ala Leu Pro Ala Leu Ala Glu Lys Asp Lys Gln 
                165                 170                 175     


Asp Leu Ile Phe Gly Cys Glu Gln Gly Val Asp Phe Val Ala Ala Ser 
            180                 185                 190         


Phe Ile Arg Lys Arg Ser Asp Val Ile Glu Ile Arg Glu His Leu Lys 
        195                 200                 205             


Ala His Gly Gly Glu Asn Ile His Ile Ile Ser Lys Ile Glu Asn Gln 
    210                 215                 220                 


Glu Gly Leu Asn Asn Phe Asp Glu Ile Leu Glu Ala Ser Asp Gly Ile 
225                 230                 235                 240 


Met Val Ala Arg Gly Asp Leu Gly Val 
                245                 


<210>  23
<211>  901
<212>  PRT
<213>  Escherichia coli

<400>  23

Met Leu Ile Pro Ser Lys Leu Ser Arg Pro Val Arg Leu Asp His Thr 
1               5                   10                  15      


Val Val Arg Glu Arg Leu Leu Ala Lys Leu Ser Gly Ala Asn Asn Phe 
            20                  25                  30          


Arg Leu Ala Leu Ile Thr Ser Pro Ala Gly Tyr Gly Lys Thr Thr Leu 
        35                  40                  45              


Ile Ser Gln Trp Ala Ala Gly Lys Asn Asp Ile Gly Trp Tyr Ser Leu 
    50                  55                  60                  


Asp Glu Gly Asp Asn Gln Gln Glu Arg Phe Ala Ser Tyr Leu Ile Ala 
65                  70                  75                  80  


Ala Val Gln Gln Ala Thr Asn Gly His Cys Ala Ile Cys Glu Thr Met 
                85                  90                  95      


Ala Gln Lys Arg Gln Tyr Ala Ser Leu Thr Ser Leu Phe Ala Gln Leu 
            100                 105                 110         


Phe Ile Glu Leu Ala Glu Trp His Ser Pro Leu Tyr Leu Val Ile Asp 
        115                 120                 125             


Asp Tyr His Leu Ile Thr Asn Pro Val Ile His Glu Ser Met Arg Phe 
    130                 135                 140                 


Phe Ile Arg His Gln Pro Glu Asn Leu Thr Leu Val Val Leu Ser Arg 
145                 150                 155                 160 


Asn Leu Pro Gln Leu Gly Ile Ala Asn Leu Arg Val Arg Asp Gln Leu 
                165                 170                 175     


Leu Glu Ile Gly Ser Gln Gln Leu Ala Phe Thr His Gln Glu Ala Lys 
            180                 185                 190         


Gln Phe Phe Asp Cys Arg Leu Ser Ser Pro Ile Glu Ala Ala Glu Ser 
        195                 200                 205             


Ser Arg Ile Cys Asp Asp Val Ser Gly Trp Ala Thr Ala Leu Gln Leu 
    210                 215                 220                 


Ile Ala Leu Ser Ala Arg Gln Asn Thr His Ser Ala His Lys Ser Ala 
225                 230                 235                 240 


Arg Arg Leu Ala Gly Ile Asn Ala Ser His Leu Ser Asp Tyr Leu Val 
                245                 250                 255     


Asp Glu Val Leu Asp Asn Val Asp Leu Ala Thr Arg His Phe Leu Leu 
            260                 265                 270         


Lys Ser Ala Ile Leu Arg Ser Met Asn Asp Ala Leu Ile Thr Arg Val 
        275                 280                 285             


Thr Gly Glu Glu Asn Gly Gln Met Arg Leu Glu Glu Ile Glu Arg Gln 
    290                 295                 300                 


Gly Leu Phe Leu Gln Arg Met Asp Asp Thr Gly Glu Trp Phe Cys Tyr 
305                 310                 315                 320 


His Pro Leu Phe Gly Asn Phe Leu Arg Gln Arg Cys Gln Trp Glu Leu 
                325                 330                 335     


Ala Ala Glu Leu Pro Glu Ile His Arg Ala Ala Ala Glu Ser Trp Met 
            340                 345                 350         


Ala Gln Gly Phe Pro Ser Glu Ala Ile His His Ala Leu Ala Ala Gly 
        355                 360                 365             


Asp Ala Leu Met Leu Arg Asp Ile Leu Leu Asn His Ala Trp Ser Leu 
    370                 375                 380                 


Phe Asn His Ser Glu Leu Ser Leu Leu Glu Glu Ser Leu Lys Ala Leu 
385                 390                 395                 400 


Pro Trp Asp Ser Leu Leu Glu Asn Pro Gln Leu Val Leu Leu Gln Ala 
                405                 410                 415     


Trp Leu Met Gln Ser Gln His Arg Tyr Gly Glu Val Asn Thr Leu Leu 
            420                 425                 430         


Ala Arg Ala Glu His Glu Ile Lys Asp Ile Arg Glu Asp Thr Met His 
        435                 440                 445             


Ala Glu Phe Asn Ala Leu Arg Ala Gln Val Ala Ile Asn Asp Gly Asn 
    450                 455                 460                 


Pro Asp Glu Ala Glu Arg Leu Ala Lys Leu Ala Leu Glu Glu Leu Pro 
465                 470                 475                 480 


Pro Gly Trp Phe Tyr Ser Arg Ile Val Ala Thr Ser Val Leu Gly Glu 
                485                 490                 495     


Val Leu His Cys Lys Gly Glu Leu Thr Arg Ser Leu Ala Leu Met Gln 
            500                 505                 510         


Gln Thr Glu Gln Met Ala Arg Gln His Asp Val Trp His Tyr Ala Leu 
        515                 520                 525             


Trp Ser Leu Ile Gln Gln Ser Glu Ile Leu Phe Ala Gln Gly Phe Leu 
    530                 535                 540                 


Gln Thr Ala Trp Glu Thr Gln Glu Lys Ala Phe Gln Leu Ile Asn Glu 
545                 550                 555                 560 


Gln His Leu Glu Gln Leu Pro Met His Glu Phe Leu Val Arg Ile Arg 
                565                 570                 575     


Ala Gln Leu Leu Trp Ala Trp Ala Arg Leu Asp Glu Ala Glu Ala Ser 
            580                 585                 590         


Ala Arg Ser Gly Ile Glu Val Leu Ser Ser Tyr Gln Pro Gln Gln Gln 
        595                 600                 605             


Leu Gln Cys Leu Ala Met Leu Ile Gln Cys Ser Leu Ala Arg Gly Asp 
    610                 615                 620                 


Leu Asp Asn Ala Arg Ser Gln Leu Asn Arg Leu Glu Asn Leu Leu Gly 
625                 630                 635                 640 


Asn Gly Lys Tyr His Ser Asp Trp Ile Ser Asn Ala Asn Lys Val Arg 
                645                 650                 655     


Val Ile Tyr Trp Gln Met Thr Gly Asp Lys Ala Ala Ala Ala Asn Trp 
            660                 665                 670         


Leu Arg His Thr Ala Lys Pro Glu Phe Ala Asn Asn His Phe Leu Gln 
        675                 680                 685             


Gly Gln Trp Arg Asn Ile Ala Arg Ala Gln Ile Leu Leu Gly Glu Phe 
    690                 695                 700                 


Glu Pro Ala Glu Ile Val Leu Glu Glu Leu Asn Glu Asn Ala Arg Ser 
705                 710                 715                 720 


Leu Arg Leu Met Ser Asp Leu Asn Arg Asn Leu Leu Leu Leu Asn Gln 
                725                 730                 735     


Leu Tyr Trp Gln Ala Gly Arg Lys Ser Asp Ala Gln Arg Val Leu Leu 
            740                 745                 750         


Asp Ala Leu Lys Leu Ala Asn Arg Thr Gly Phe Ile Ser His Phe Val 
        755                 760                 765             


Ile Glu Gly Glu Ala Met Ala Gln Gln Leu Arg Gln Leu Ile Gln Leu 
    770                 775                 780                 


Asn Thr Leu Pro Glu Leu Glu Gln His Arg Ala Gln Arg Ile Leu Arg 
785                 790                 795                 800 


Glu Ile Asn Gln His His Arg His Lys Phe Ala His Phe Asp Glu Asn 
                805                 810                 815     


Phe Val Glu Arg Leu Leu Asn His Pro Glu Val Pro Glu Leu Ile Arg 
            820                 825                 830         


Thr Ser Pro Leu Thr Gln Arg Glu Trp Gln Val Leu Gly Leu Ile Tyr 
        835                 840                 845             


Ser Gly Tyr Ser Asn Glu Gln Ile Ala Gly Glu Leu Glu Val Ala Ala 
    850                 855                 860                 


Thr Thr Ile Lys Thr His Ile Arg Asn Leu Tyr Gln Lys Leu Gly Val 
865                 870                 875                 880 


Ala His Arg Gln Asp Ala Val Gln His Ala Gln Gln Leu Leu Lys Met 
                885                 890                 895     


Met Gly Tyr Gly Val 
            900     


<210>  24
<211>  779
<212>  PRT
<213>  Escherichia coli

<400>  24

Met Leu Ile Pro Ser Lys Leu Ser Arg Pro Val Arg Leu Asp His Thr 
1               5                   10                  15      


Val Val Arg Glu Arg Leu Leu Ala Lys Leu Ser Gly Ala Asn Asn Phe 
            20                  25                  30          


Arg Leu Ala Leu Ile Thr Ser Pro Ala Gly Tyr Gly Lys Thr Thr Leu 
        35                  40                  45              


Ile Ser Gln Trp Ala Ala Gly Lys Asn Asp Ile Gly Trp Tyr Ser Leu 
    50                  55                  60                  


Asp Glu Gly Asp Asn Gln Gln Glu Arg Phe Ala Ser Tyr Leu Ile Ala 
65                  70                  75                  80  


Ala Val Gln Gln Ala Thr Asn Gly His Cys Ala Ile Cys Glu Thr Met 
                85                  90                  95      


Ala Gln Lys Arg Gln Tyr Ala Ser Leu Thr Ser Leu Phe Ala Gln Leu 
            100                 105                 110         


Phe Ile Glu Leu Ala Glu Trp His Ser Pro Leu Tyr Leu Val Ile Asp 
        115                 120                 125             


Asp Tyr His Leu Ile Thr Asn Pro Val Ile His Glu Ser Met Arg Phe 
    130                 135                 140                 


Phe Ile Arg His Gln Pro Glu Asn Leu Thr Leu Val Val Leu Ser Arg 
145                 150                 155                 160 


Asn Leu Pro Gln Leu Gly Ile Ala Asn Leu Arg Val Arg Asp Gln Leu 
                165                 170                 175     


Leu Glu Ile Gly Ser Gln Gln Leu Ala Phe Thr His Gln Glu Ala Lys 
            180                 185                 190         


Gln Phe Phe Asp Cys Arg Leu Ser Ser Pro Ile Glu Ala Ala Glu Ser 
        195                 200                 205             


Ser Arg Ile Cys Asp Asp Val Ser Gly Trp Ala Thr Ala Leu Gln Leu 
    210                 215                 220                 


Ile Ala Leu Ser Ala Arg Gln Asn Thr His Ser Ala His Lys Ser Ala 
225                 230                 235                 240 


Arg Arg Leu Ala Gly Ile Asn Ala Ser His Leu Ser Asp Tyr Leu Val 
                245                 250                 255     


Asp Glu Val Leu Asp Asn Val Asp Leu Ala Thr Arg His Phe Leu Leu 
            260                 265                 270         


Lys Ser Ala Ile Leu Arg Ser Met Asn Asp Ala Leu Ile Thr Arg Val 
        275                 280                 285             


Thr Gly Glu Glu Asn Gly Gln Met Arg Leu Glu Glu Ile Glu Arg Gln 
    290                 295                 300                 


Gly Leu Phe Leu Gln Arg Met Asp Asp Thr Gly Glu Trp Phe Cys Tyr 
305                 310                 315                 320 


His Pro Leu Phe Gly Asn Phe Leu Arg Gln Arg Cys Gln Trp Glu Leu 
                325                 330                 335     


Ala Ala Glu Leu Pro Glu Ile His Arg Ala Ala Ala Glu Ser Trp Met 
            340                 345                 350         


Ala Gln Gly Phe Pro Ser Glu Ala Ile His His Ala Leu Ala Ala Gly 
        355                 360                 365             


Asp Ala Leu Met Leu Arg Asp Ile Leu Leu Asn His Ala Trp Ser Leu 
    370                 375                 380                 


Phe Asn His Ser Glu Leu Ser Leu Leu Glu Glu Ser Leu Lys Ala Leu 
385                 390                 395                 400 


Pro Trp Asp Ser Leu Leu Glu Asn Pro Gln Leu Val Leu Leu Gln Ala 
                405                 410                 415     


Trp Leu Met Gln Ser Gln His Arg Tyr Gly Glu Val Asn Thr Leu Leu 
            420                 425                 430         


Ala Arg Ala Glu His Glu Ile Lys Asp Ile Arg Glu Asp Thr Met His 
        435                 440                 445             


Ala Glu Phe Asn Ala Leu Arg Ala Gln Val Ala Ile Asn Asp Gly Asn 
    450                 455                 460                 


Pro Asp Glu Ala Glu Arg Leu Ala Lys Leu Ala Leu Glu Glu Leu Pro 
465                 470                 475                 480 


Pro Gly Trp Phe Tyr Ser Arg Ile Val Ala Thr Ser Val Leu Gly Glu 
                485                 490                 495     


Val Leu His Cys Lys Gly Glu Leu Thr Arg Ser Leu Ala Leu Met Gln 
            500                 505                 510         


Gln Thr Glu Gln Met Ala Arg Gln His Asp Val Trp His Tyr Ala Leu 
        515                 520                 525             


Trp Ser Leu Ile Gln Gln Ser Glu Ile Leu Phe Ala Gln Gly Phe Leu 
    530                 535                 540                 


Gln Thr Ala Trp Glu Thr Gln Glu Lys Ala Phe Gln Leu Ile Asn Glu 
545                 550                 555                 560 


Gln His Leu Glu Gln Leu Pro Met His Glu Phe Leu Val Arg Ile Arg 
                565                 570                 575     


Ala Gln Leu Leu Trp Ala Trp Ala Arg Leu Asp Glu Ala Glu Ala Ser 
            580                 585                 590         


Ala Arg Ser Gly Ile Glu Val Leu Ser Ser Tyr Gln Pro Gln Gln Gln 
        595                 600                 605             


Leu Gln Cys Leu Ala Met Leu Ile Gln Cys Ser Leu Ala Arg Gly Asp 
    610                 615                 620                 


Leu Asp Asn Ala Arg Ser Gln Leu Asn Arg Leu Glu Asn Leu Leu Gly 
625                 630                 635                 640 


Asn Gly Lys Tyr His Ser Asp Trp Ile Ser Asn Ala Asn Lys Val Arg 
                645                 650                 655     


Val Ile Tyr Trp Gln Met Thr Gly Asp Lys Ala Ala Ala Ala Asn Trp 
            660                 665                 670         


Leu Arg His Thr Ala Lys Pro Glu Phe Ala Asn Asn His Phe Leu Gln 
        675                 680                 685             


Gly Gln Trp Arg Asn Ile Ala Arg Ala Gln Ile Leu Leu Gly Glu Phe 
    690                 695                 700                 


Glu Pro Ala Glu Ile Val Leu Glu Glu Leu Asn Glu Asn Ala Arg Ser 
705                 710                 715                 720 


Leu Arg Leu Met Ser Asp Leu Asn Arg Asn Leu Leu Leu Leu Asn Gln 
                725                 730                 735     


Leu Tyr Trp Gln Ala Gly Arg Lys Ser Asp Ala Gln Arg Val Leu Leu 
            740                 745                 750         


Asp Ala Leu Lys Leu Ala Asn Arg Thr Gly Phe Ile Ser His Phe Val 
        755                 760                 765             


Ile Glu Gly Glu Ala Met Ala Gln Gln Leu Arg 
    770                 775                 


<210>  25
<211>  1342
<212>  PRT
<213>  Escherichia coli

<400>  25

Met Val Tyr Ser Tyr Thr Glu Lys Lys Arg Ile Arg Lys Asp Phe Gly 
1               5                   10                  15      


Lys Arg Pro Gln Val Leu Asp Val Pro Tyr Leu Leu Ser Ile Gln Leu 
            20                  25                  30          


Asp Ser Phe Gln Lys Phe Ile Glu Gln Asp Pro Glu Gly Gln Tyr Gly 
        35                  40                  45              


Leu Glu Ala Ala Phe Arg Ser Val Phe Pro Ile Gln Ser Tyr Ser Gly 
    50                  55                  60                  


Asn Ser Glu Leu Gln Tyr Val Ser Tyr Arg Leu Gly Glu Pro Val Phe 
65                  70                  75                  80  


Asp Val Gln Glu Cys Gln Ile Arg Gly Val Thr Tyr Ser Ala Pro Leu 
                85                  90                  95      


Arg Val Lys Leu Arg Leu Val Ile Tyr Glu Arg Glu Ala Pro Glu Gly 
            100                 105                 110         


Thr Val Lys Asp Ile Lys Glu Gln Glu Val Tyr Met Gly Glu Ile Pro 
        115                 120                 125             


Leu Met Thr Asp Asn Gly Thr Phe Val Ile Asn Gly Thr Glu Arg Val 
    130                 135                 140                 


Ile Val Ser Gln Leu His Arg Ser Pro Gly Val Phe Phe Asp Ser Asp 
145                 150                 155                 160 


Lys Gly Lys Thr His Ser Ser Gly Lys Val Leu Tyr Asn Ala Arg Ile 
                165                 170                 175     


Ile Pro Tyr Arg Gly Ser Trp Leu Asp Phe Glu Phe Asp Pro Lys Asp 
            180                 185                 190         


Asn Leu Phe Val Arg Ile Asp Arg Arg Arg Lys Leu Pro Ala Thr Ile 
        195                 200                 205             


Ile Leu Arg Ala Leu Asn Tyr Thr Thr Glu Gln Ile Leu Asp Leu Phe 
    210                 215                 220                 


Phe Glu Lys Val Ile Phe Glu Ile Arg Asp Asn Lys Leu Gln Met Glu 
225                 230                 235                 240 


Leu Val Pro Glu Arg Leu Arg Gly Glu Thr Ala Ser Phe Asp Ile Glu 
                245                 250                 255     


Ala Asn Gly Lys Val Tyr Val Glu Lys Gly Arg Arg Ile Thr Ala Arg 
            260                 265                 270         


His Ile Arg Gln Leu Glu Lys Asp Asp Val Lys Leu Ile Glu Val Pro 
        275                 280                 285             


Val Glu Tyr Ile Ala Gly Lys Val Val Ala Lys Asp Tyr Ile Asp Glu 
    290                 295                 300                 


Ser Thr Gly Glu Leu Ile Cys Ala Ala Asn Met Glu Leu Ser Leu Asp 
305                 310                 315                 320 


Leu Leu Ala Lys Leu Ser Gln Ser Gly His Lys Arg Ile Glu Thr Leu 
                325                 330                 335     


Phe Thr Asn Asp Leu Asp His Gly Pro Tyr Ile Ser Glu Thr Leu Arg 
            340                 345                 350         


Val Asp Pro Thr Asn Asp Arg Leu Ser Ala Leu Val Glu Ile Tyr Arg 
        355                 360                 365             


Met Met Arg Pro Gly Glu Pro Pro Thr Arg Glu Ala Ala Glu Ser Leu 
    370                 375                 380                 


Phe Glu Asn Leu Phe Phe Ser Glu Asp Arg Tyr Asp Leu Ser Ala Val 
385                 390                 395                 400 


Gly Arg Met Lys Phe Asn Arg Ser Leu Leu Arg Glu Glu Ile Glu Gly 
                405                 410                 415     


Ser Gly Ile Leu Ser Lys Asp Asp Ile Ile Asp Val Met Lys Lys Leu 
            420                 425                 430         


Ile Asp Ile Arg Asn Gly Lys Gly Glu Val Asp Asp Ile Asp His Leu 
        435                 440                 445             


Gly Asn Arg Arg Ile Arg Ser Val Gly Glu Met Ala Glu Asn Gln Phe 
    450                 455                 460                 


Arg Val Gly Leu Val Arg Val Glu Arg Ala Val Lys Glu Arg Leu Ser 
465                 470                 475                 480 


Leu Gly Asp Leu Asp Thr Leu Met Pro Gln Asp Met Ile Asn Ala Lys 
                485                 490                 495     


Pro Ile Ser Ala Ala Val Lys Glu Phe Phe Gly Ser Ser Gln Leu Ser 
            500                 505                 510         


Gln Phe Met Asp Gln Asn Asn Pro Leu Ser Glu Ile Thr His Lys Arg 
        515                 520                 525             


Arg Ile Ser Ala Leu Gly Pro Gly Gly Leu Thr Arg Glu Arg Ala Gly 
    530                 535                 540                 


Phe Glu Val Arg Asp Val His Pro Thr His Tyr Gly Arg Val Cys Pro 
545                 550                 555                 560 


Ile Glu Thr Pro Glu Gly Pro Asn Ile Gly Leu Ile Asn Ser Leu Ser 
                565                 570                 575     


Val Tyr Ala Gln Thr Asn Glu Tyr Gly Phe Leu Glu Thr Pro Tyr Arg 
            580                 585                 590         


Lys Val Thr Asp Gly Val Val Thr Asp Glu Ile His Tyr Leu Ser Ala 
        595                 600                 605             


Ile Glu Glu Gly Asn Tyr Val Ile Ala Gln Ala Asn Ser Asn Leu Asp 
    610                 615                 620                 


Glu Glu Gly His Phe Val Glu Asp Leu Val Thr Cys Arg Ser Lys Gly 
625                 630                 635                 640 


Glu Ser Ser Leu Phe Ser Arg Asp Gln Val Asp Tyr Met Asp Val Ser 
                645                 650                 655     


Thr Gln Gln Val Val Ser Val Gly Ala Ser Leu Ile Pro Phe Leu Glu 
            660                 665                 670         


His Asp Asp Ala Asn Arg Ala Leu Met Gly Ala Asn Met Gln Arg Gln 
        675                 680                 685             


Ala Val Pro Thr Leu Arg Ala Asp Lys Pro Leu Val Gly Thr Gly Met 
    690                 695                 700                 


Glu Arg Ala Val Ala Val Asp Ser Gly Val Thr Ala Val Ala Lys Arg 
705                 710                 715                 720 


Gly Gly Val Val Gln Tyr Val Asp Ala Ser Arg Ile Val Ile Lys Val 
                725                 730                 735     


Asn Glu Asp Glu Met Tyr Pro Gly Glu Ala Gly Ile Asp Ile Tyr Asn 
            740                 745                 750         


Leu Thr Lys Tyr Thr Arg Ser Asn Gln Asn Thr Cys Ile Asn Gln Met 
        755                 760                 765             


Pro Cys Val Ser Leu Gly Glu Pro Val Glu Arg Gly Asp Val Leu Ala 
    770                 775                 780                 


Asp Gly Pro Ser Thr Asp Leu Gly Glu Leu Ala Leu Gly Gln Asn Met 
785                 790                 795                 800 


Arg Val Ala Phe Met Pro Trp Asn Gly Tyr Asn Phe Glu Asp Ser Ile 
                805                 810                 815     


Leu Val Ser Glu Arg Val Val Gln Glu Asp Arg Phe Thr Thr Ile His 
            820                 825                 830         


Ile Gln Glu Leu Ala Cys Val Ser Arg Asp Thr Lys Leu Gly Pro Glu 
        835                 840                 845             


Glu Ile Thr Ala Asp Ile Pro Asn Val Gly Glu Ala Ala Leu Ser Lys 
    850                 855                 860                 


Leu Asp Glu Ser Gly Ile Val Tyr Ile Gly Ala Glu Val Thr Gly Gly 
865                 870                 875                 880 


Asp Ile Leu Val Gly Lys Val Thr Pro Lys Gly Glu Thr Gln Leu Thr 
                885                 890                 895     


Pro Glu Glu Lys Leu Leu Arg Ala Ile Phe Gly Glu Lys Ala Ser Asp 
            900                 905                 910         


Val Lys Asp Ser Ser Leu Arg Val Pro Asn Gly Val Ser Gly Thr Val 
        915                 920                 925             


Ile Asp Val Gln Val Phe Thr Arg Asp Gly Val Glu Lys Asp Lys Arg 
    930                 935                 940                 


Ala Leu Glu Ile Glu Glu Met Gln Leu Lys Gln Ala Lys Lys Asp Leu 
945                 950                 955                 960 


Ser Glu Glu Leu Gln Ile Leu Glu Ala Gly Leu Phe Ser Arg Ile Arg 
                965                 970                 975     


Ala Val Leu Val Ala Gly Gly Val Glu Ala Glu Lys Leu Asp Lys Leu 
            980                 985                 990         


Pro Arg Asp Arg Trp Leu Glu Leu  Gly Leu Thr Asp Glu  Glu Lys Gln 
        995                 1000                 1005             


Asn Gln  Leu Glu Gln Leu Ala  Glu Gln Tyr Asp Glu  Leu Lys His 
    1010                 1015                 1020             


Glu Phe  Glu Lys Lys Leu Glu  Ala Lys Arg Arg Lys  Ile Thr Gln 
    1025                 1030                 1035             


Gly Asp  Asp Leu Ala Pro Gly  Val Leu Lys Ile Val  Lys Val Tyr 
    1040                 1045                 1050             


Leu Ala  Val Lys Arg Arg Ile  Gln Pro Gly Asp Lys  Met Ala Gly 
    1055                 1060                 1065             


Arg His  Gly Asn Lys Gly Val  Ile Ser Lys Ile Asn  Pro Ile Glu 
    1070                 1075                 1080             


Asp Met  Pro Tyr Asp Glu Asn  Gly Thr Pro Val Asp  Ile Val Leu 
    1085                 1090                 1095             


Asn Pro  Leu Gly Val Pro Ser  Arg Met Asn Ile Gly  Gln Ile Leu 
    1100                 1105                 1110             


Glu Thr  His Leu Gly Met Ala  Ala Lys Gly Ile Gly  Asp Lys Ile 
    1115                 1120                 1125             


Asn Ala  Met Leu Lys Gln Gln  Gln Glu Val Ala Lys  Leu Arg Glu 
    1130                 1135                 1140             


Phe Ile  Gln Arg Ala Tyr Asp  Leu Gly Ala Asp Val  Arg Gln Lys 
    1145                 1150                 1155             


Val Asp  Leu Ser Thr Phe Ser  Asp Glu Glu Val Met  Arg Leu Ala 
    1160                 1165                 1170             


Glu Asn  Leu Arg Lys Gly Met  Pro Ile Ala Thr Pro  Val Phe Asp 
    1175                 1180                 1185             


Gly Ala  Lys Glu Ala Glu Ile  Lys Glu Leu Leu Lys  Leu Gly Asp 
    1190                 1195                 1200             


Leu Pro  Thr Ser Gly Gln Ile  Arg Leu Tyr Asp Gly  Arg Thr Gly 
    1205                 1210                 1215             


Glu Gln  Phe Glu Arg Pro Val  Thr Val Gly Tyr Met  Tyr Met Leu 
    1220                 1225                 1230             


Lys Leu  Asn His Leu Val Asp  Asp Lys Met His Ala  Arg Ser Thr 
    1235                 1240                 1245             


Gly Ser  Tyr Ser Leu Val Thr  Gln Gln Pro Leu Gly  Gly Lys Ala 
    1250                 1255                 1260             


Gln Phe  Gly Gly Gln Arg Phe  Gly Glu Met Glu Val  Trp Ala Leu 
    1265                 1270                 1275             


Glu Ala  Tyr Gly Ala Ala Tyr  Thr Leu Gln Glu Met  Leu Thr Val 
    1280                 1285                 1290             


Lys Ser  Asp Asp Val Asn Gly  Arg Thr Lys Met Tyr  Lys Asn Ile 
    1295                 1300                 1305             


Val Asp  Gly Asn His Gln Met  Glu Pro Gly Met Pro  Glu Ser Phe 
    1310                 1315                 1320             


Asn Val  Leu Leu Lys Glu Ile  Arg Ser Leu Gly Ile  Asn Ile Glu 
    1325                 1330                 1335             


Leu Glu  Asp Glu 
    1340         


<210>  26
<211>  548
<212>  PRT
<213>  Escherichia coli

<400>  26

Met Ser Asn Lys Pro Phe Ile Tyr Gln Ala Pro Phe Pro Met Gly Lys 
1               5                   10                  15      


Asp Asn Thr Glu Tyr Tyr Leu Leu Thr Ser Asp Tyr Val Ser Val Ala 
            20                  25                  30          


Asp Phe Asp Gly Glu Thr Ile Leu Lys Val Glu Pro Glu Ala Leu Thr 
        35                  40                  45              


Leu Leu Ala Gln Gln Ala Phe His Asp Ala Ser Phe Met Leu Arg Pro 
    50                  55                  60                  


Ala His Gln Lys Gln Val Ala Ala Ile Leu His Asp Pro Glu Ala Ser 
65                  70                  75                  80  


Glu Asn Asp Lys Tyr Val Ala Leu Gln Phe Leu Arg Asn Ser Glu Ile 
                85                  90                  95      


Ala Ala Lys Gly Val Leu Pro Thr Cys Gln Asp Thr Gly Thr Ala Ile 
            100                 105                 110         


Ile Val Gly Lys Lys Gly Gln Arg Val Trp Thr Gly Gly Gly Asp Glu 
        115                 120                 125             


Glu Thr Leu Ser Lys Gly Val Tyr Asn Thr Tyr Ile Glu Asp Asn Leu 
    130                 135                 140                 


Arg Tyr Ser Gln Asn Ala Ala Leu Asp Met Tyr Lys Glu Val Asn Thr 
145                 150                 155                 160 


Gly Thr Asn Leu Pro Ala Gln Ile Asp Leu Tyr Ala Val Asp Gly Asp 
                165                 170                 175     


Glu Tyr Lys Phe Leu Cys Val Ala Lys Gly Gly Gly Ser Ala Asn Lys 
            180                 185                 190         


Thr Tyr Leu Tyr Gln Glu Thr Lys Ala Leu Leu Thr Pro Gly Lys Leu 
        195                 200                 205             


Lys Asn Phe Leu Val Glu Lys Met Arg Thr Leu Gly Thr Ala Ala Cys 
    210                 215                 220                 


Pro Pro Tyr His Ile Ala Phe Val Ile Gly Gly Thr Ser Ala Glu Thr 
225                 230                 235                 240 


Asn Leu Lys Thr Val Lys Leu Ala Ser Ala His Tyr Tyr Asp Glu Leu 
                245                 250                 255     


Pro Thr Glu Gly Asn Glu His Gly Gln Ala Phe Arg Asp Val Gln Leu 
            260                 265                 270         


Glu Gln Glu Leu Leu Glu Glu Ala Gln Lys Leu Gly Leu Gly Ala Gln 
        275                 280                 285             


Phe Gly Gly Lys Tyr Phe Ala His Asp Ile Arg Val Ile Arg Leu Pro 
    290                 295                 300                 


Arg His Gly Ala Ser Cys Pro Val Gly Met Gly Val Ser Cys Ser Ala 
305                 310                 315                 320 


Asp Arg Asn Ile Lys Ala Lys Ile Asn Arg Glu Gly Ile Trp Ile Glu 
                325                 330                 335     


Lys Leu Glu His Asn Pro Gly Gln Tyr Ile Pro Gln Glu Leu Arg Gln 
            340                 345                 350         


Ala Gly Glu Gly Glu Ala Val Lys Val Asp Leu Asn Arg Pro Met Lys 
        355                 360                 365             


Glu Ile Leu Ala Gln Leu Ser Gln Tyr Pro Val Ser Thr Arg Leu Ser 
    370                 375                 380                 


Leu Thr Gly Thr Ile Ile Val Gly Arg Asp Ile Ala His Ala Lys Leu 
385                 390                 395                 400 


Lys Glu Leu Ile Asp Ala Gly Lys Glu Leu Pro Gln Tyr Ile Lys Asp 
                405                 410                 415     


His Pro Ile Tyr Tyr Ala Gly Pro Ala Lys Thr Pro Ala Gly Tyr Pro 
            420                 425                 430         


Ser Gly Ser Leu Gly Pro Thr Thr Ala Gly Arg Met Asp Ser Tyr Val 
        435                 440                 445             


Asp Leu Leu Gln Ser His Gly Gly Ser Met Ile Met Leu Ala Lys Gly 
    450                 455                 460                 


Asn Arg Ser Gln Gln Val Thr Asp Ala Cys His Lys His Gly Gly Phe 
465                 470                 475                 480 


Tyr Leu Gly Ser Ile Gly Gly Pro Ala Ala Val Leu Ala Gln Gln Ser 
                485                 490                 495     


Ile Lys His Leu Glu Cys Val Ala Tyr Pro Glu Leu Gly Met Glu Ala 
            500                 505                 510         


Ile Trp Lys Ile Glu Val Glu Asp Phe Pro Ala Phe Ile Leu Val Asp 
        515                 520                 525             


Asp Lys Gly Asn Asp Phe Phe Gln Gln Ile Val Asn Lys Gln Cys Ala 
    530                 535                 540                 


Asn Cys Thr Lys 
545             


<210>  27
<211>  518
<212>  PRT
<213>  Escherichia coli

<400>  27

Met Ile Pro Asp Val Ser Gln Ala Leu Ala Trp Leu Glu Lys His Pro 
1               5                   10                  15      


Gln Ala Leu Lys Gly Ile Gln Arg Gly Leu Glu Arg Glu Thr Leu Arg 
            20                  25                  30          


Val Asn Ala Asp Gly Thr Leu Ala Thr Thr Gly His Pro Glu Ala Leu 
        35                  40                  45              


Gly Ser Ala Leu Thr His Lys Trp Ile Thr Thr Asp Phe Ala Glu Ala 
    50                  55                  60                  


Leu Leu Glu Phe Ile Thr Pro Val Asp Gly Asp Ile Glu His Met Leu 
65                  70                  75                  80  


Thr Phe Met Arg Asp Leu His Arg Tyr Thr Ala Arg Asn Met Gly Asp 
                85                  90                  95      


Glu Arg Met Trp Pro Leu Ser Met Pro Cys Tyr Ile Ala Glu Gly Gln 
            100                 105                 110         


Asp Ile Glu Leu Ala Gln Tyr Gly Thr Ser Asn Thr Gly Arg Phe Lys 
        115                 120                 125             


Thr Leu Tyr Arg Glu Gly Leu Lys Asn Arg Tyr Gly Ala Leu Met Gln 
    130                 135                 140                 


Thr Ile Ser Gly Val His Tyr Asn Phe Ser Leu Pro Met Ala Phe Trp 
145                 150                 155                 160 


Gln Ala Lys Cys Gly Asp Ile Ser Gly Ala Asp Ala Lys Glu Lys Ile 
                165                 170                 175     


Ser Ala Gly Tyr Phe Arg Val Ile Arg Asn Tyr Tyr Arg Phe Gly Trp 
            180                 185                 190         


Val Ile Pro Tyr Leu Phe Gly Ala Ser Pro Ala Ile Cys Ser Ser Phe 
        195                 200                 205             


Leu Gln Gly Lys Pro Thr Ser Leu Pro Phe Glu Lys Thr Glu Cys Gly 
    210                 215                 220                 


Met Tyr Tyr Leu Pro Tyr Ala Thr Ser Leu Arg Leu Ser Asp Leu Gly 
225                 230                 235                 240 


Tyr Thr Asn Lys Ser Gln Ser Asn Leu Gly Ile Thr Phe Asn Asp Leu 
                245                 250                 255     


Tyr Glu Tyr Val Ala Gly Leu Lys Gln Ala Ile Lys Thr Pro Ser Glu 
            260                 265                 270         


Glu Tyr Ala Lys Ile Gly Ile Glu Lys Asp Gly Lys Arg Leu Gln Ile 
        275                 280                 285             


Asn Ser Asn Val Leu Gln Ile Glu Asn Glu Leu Tyr Ala Pro Ile Arg 
    290                 295                 300                 


Pro Lys Arg Val Thr Arg Ser Gly Glu Ser Pro Ser Asp Ala Leu Leu 
305                 310                 315                 320 


Arg Gly Gly Ile Glu Tyr Ile Glu Val Arg Ser Leu Asp Ile Asn Pro 
                325                 330                 335     


Phe Ser Pro Ile Gly Val Asp Glu Gln Gln Val Arg Phe Leu Asp Leu 
            340                 345                 350         


Phe Met Val Trp Cys Ala Leu Ala Asp Ala Pro Glu Met Ser Ser Ser 
        355                 360                 365             


Glu Leu Ala Cys Thr Arg Val Asn Trp Asn Arg Val Ile Leu Glu Gly 
    370                 375                 380                 


Arg Lys Pro Gly Leu Thr Leu Gly Ile Gly Cys Glu Thr Ala Gln Phe 
385                 390                 395                 400 


Pro Leu Pro Gln Val Gly Lys Asp Leu Phe Arg Asp Leu Lys Arg Val 
                405                 410                 415     


Ala Gln Thr Leu Asp Ser Ile Asn Gly Gly Glu Ala Tyr Gln Lys Val 
            420                 425                 430         


Cys Asp Glu Leu Val Ala Cys Phe Asp Asn Pro Asp Leu Thr Phe Ser 
        435                 440                 445             


Ala Arg Ile Leu Arg Ser Met Ile Asp Thr Gly Ile Gly Gly Thr Gly 
    450                 455                 460                 


Lys Ala Phe Ala Glu Ala Tyr Arg Asn Leu Leu Arg Glu Glu Pro Leu 
465                 470                 475                 480 


Glu Ile Leu Arg Glu Glu Asp Phe Val Ala Glu Arg Glu Ala Ser Glu 
                485                 490                 495     


Arg Arg Gln Gln Glu Met Glu Ala Ala Asp Thr Glu Pro Phe Ala Val 
            500                 505                 510         


Trp Leu Glu Lys His Ala 
        515             


<210>  28
<211>  446
<212>  PRT
<213>  Escherichia coli

<400>  28

Met Met Ile Thr Leu Arg Lys Leu Pro Leu Ala Val Ala Val Ala Ala 
1               5                   10                  15      


Gly Val Met Ser Ala Gln Ala Met Ala Val Asp Phe His Gly Tyr Ala 
            20                  25                  30          


Arg Ser Gly Ile Gly Trp Thr Gly Ser Gly Gly Glu Gln Gln Cys Phe 
        35                  40                  45              


Gln Thr Thr Gly Ala Gln Ser Lys Tyr Arg Leu Gly Asn Glu Cys Glu 
    50                  55                  60                  


Thr Tyr Ala Glu Leu Lys Leu Gly Gln Glu Val Trp Lys Glu Gly Asp 
65                  70                  75                  80  


Lys Ser Phe Tyr Phe Asp Thr Asn Val Ala Tyr Ser Val Ala Gln Gln 
                85                  90                  95      


Asn Asp Trp Glu Ala Thr Asp Pro Ala Phe Arg Glu Ala Asn Val Gln 
            100                 105                 110         


Gly Lys Asn Leu Ile Glu Trp Leu Pro Gly Ser Thr Ile Trp Ala Gly 
        115                 120                 125             


Lys Arg Phe Tyr Gln Arg His Asp Val His Met Ile Asp Phe Tyr Tyr 
    130                 135                 140                 


Trp Asp Ile Ser Gly Pro Gly Ala Gly Leu Glu Asn Ile Asp Val Gly 
145                 150                 155                 160 


Phe Gly Lys Leu Ser Leu Ala Ala Thr Arg Ser Ser Glu Ala Gly Gly 
                165                 170                 175     


Ser Ser Ser Phe Ala Ser Asn Asn Ile Tyr Asp Tyr Thr Asn Glu Thr 
            180                 185                 190         


Ala Asn Asp Val Phe Asp Val Arg Leu Ala Gln Met Glu Ile Asn Pro 
        195                 200                 205             


Gly Gly Thr Leu Glu Leu Gly Val Asp Tyr Gly Arg Ala Asn Leu Arg 
    210                 215                 220                 


Asp Asn Tyr Arg Leu Val Asp Gly Ala Ser Lys Asp Gly Trp Leu Phe 
225                 230                 235                 240 


Thr Ala Glu His Thr Gln Ser Val Leu Lys Gly Phe Asn Lys Phe Val 
                245                 250                 255     


Val Gln Tyr Ala Thr Asp Ser Met Thr Ser Gln Gly Lys Gly Leu Ser 
            260                 265                 270         


Gln Gly Ser Gly Val Ala Phe Asp Asn Glu Lys Phe Ala Tyr Asn Ile 
        275                 280                 285             


Asn Asn Asn Gly His Met Leu Arg Ile Leu Asp His Gly Ala Ile Ser 
    290                 295                 300                 


Met Gly Asp Asn Trp Asp Met Met Tyr Val Gly Met Tyr Gln Asp Ile 
305                 310                 315                 320 


Asn Trp Asp Asn Asp Asn Gly Thr Lys Trp Trp Thr Val Gly Ile Arg 
                325                 330                 335     


Pro Met Tyr Lys Trp Thr Pro Ile Met Ser Thr Val Met Glu Ile Gly 
            340                 345                 350         


Tyr Asp Asn Val Glu Ser Gln Arg Thr Gly Asp Lys Asn Asn Gln Tyr 
        355                 360                 365             


Lys Ile Thr Leu Ala Gln Gln Trp Gln Ala Gly Asp Ser Ile Trp Ser 
    370                 375                 380                 


Arg Pro Ala Ile Arg Val Phe Ala Thr Tyr Ala Lys Trp Asp Glu Lys 
385                 390                 395                 400 


Trp Gly Tyr Asp Tyr Thr Gly Asn Ala Asp Asn Asn Ala Asn Phe Gly 
                405                 410                 415     


Lys Ala Val Pro Ala Asp Phe Asn Gly Gly Ser Phe Gly Arg Gly Asp 
            420                 425                 430         


Ser Asp Glu Trp Thr Phe Gly Ala Gln Met Glu Ile Trp Trp 
        435                 440                 445     


<210>  29
<211>  111
<212>  PRT
<213>  Escherichia coli

<400>  29

Met Met Ile Thr Leu Arg Lys Leu Pro Leu Ala Val Ala Val Ala Ala 
1               5                   10                  15      


Gly Val Met Ser Ala Gln Ala Met Ala Val Asp Phe His Gly Tyr Ala 
            20                  25                  30          


Arg Ser Gly Ile Gly Trp Thr Gly Ser Gly Gly Glu Gln Gln Cys Phe 
        35                  40                  45              


Gln Thr Thr Gly Ala Gln Ser Lys Tyr Arg Leu Gly Asn Glu Cys Glu 
    50                  55                  60                  


Thr Tyr Ala Glu Leu Lys Leu Gly Gln Glu Val Trp Lys Glu Gly Asp 
65                  70                  75                  80  


Lys Ser Phe Tyr Phe Asp Thr Asn Val Ala Tyr Ser Val Ala Gln Gln 
                85                  90                  95      


Asn Asp Trp Glu Ala Thr Asp Pro Ala Phe Arg Glu Ala Asn Val 
            100                 105                 110     


<210>  30
<211>  1476
<212>  DNA
<213>  Escherichia coli

<400>  30
atggcggtaa cgcaaacagc ccaggcctgt gacctggtca ttttcggcgc gaaaggcgac       60

cttgcgcgtc gtaaattgct gccttccctg tatcaactgg aaaaagccgg tcagctcaac      120

ccggacaccc ggattatcgg cgtagggcgt gctgactggg ataaagcggc atataccaaa      180

gttgtccgcg aggcgctcga aactttcatg aaagaaacca ttgatgaagg tttatgggac      240

accctgagtg cacgtctgga tttttgtaat ctcgatgtca atgacactgc tgcattcagc      300

cgtctcggcg cgatgctgga tcaaaaaaat cgtatcacca ttaactactt tgccatgccg      360

cccagcactt ttggcgcaat ttgcaaaggg cttggcgagg caaaactgaa tgctaaaccg      420

gcacgcgtag tcatggagaa accgctgggg acgtcgctgg cgacctcgca ggaaatcaat      480

gatcaggttg gcgaatactt cgaggagtgc caggtttacc gtatcgacca ctatcttggt      540

aaagaaacgg tgctgaacct gttggcgctg cgttttgcta actccctgtt tgtgaataac      600

tgggacaatc gcaccattga tcatgttgag attaccgtgg cagaagaagt ggggatcgaa      660

gggcgctggg gctattttga taaagccggt cagatgcgcg acatgatcca gaaccacctg      720

ctgcaaattc tttgcatgat tgcgatgtct ccgccgtctg acctgagcgc agacagcatc      780

cgcgatgaaa aagtgaaagt actgaagtct ctgcgccgca tcgaccgctc caacgtacgc      840

gaaaaaaccg tacgcgggca atatactgcg ggcttcgccc agggcaaaaa agtgccggga      900

tatctggaag aagagggcgc gaacaagagc agcaatacag aaactttcgt ggcgatccgc      960

gtcgacattg ataactggcg ctgggccggt gtgccattct acctgcgtac tggtaaacgt     1020

ctgccgacca aatgttctga agtcgtggtc tatttcaaaa cacctgaact gaatctgttt     1080

aaagaatcgt ggcaggatct gccgcagaat aaactgacta tccgtctgca acctgatgaa     1140

ggcgtggata tccaggtact gaataaagtt cctggccttg accacaaaca taacctgcaa     1200

atcaccaagc tggatctgag ctattcagaa acctttaatc agacgcatct ggcggatgcc     1260

tatgaacgtt tgctgctgga aaccatgcgt ggtattcagg cactgtttgt acgtcgcgac     1320

gaagtggaag aagcctggaa atgggtagac tccattactg aggcgtgggc gatggacaat     1380

gatgcgccga aaccgtatca ggccggaacc tggggacccg ttgcctcggt ggcgatgatt     1440

acccgtgatg gtcgttcctg gaatgagttt gagtaa                               1476


<210>  31
<211>  439
<212>  PRT
<213>  Escherichia coli

<400>  31

Met Thr His Gln Leu Arg Ser Arg Asp Ile Ile Ala Leu Gly Phe Met 
1               5                   10                  15      


Thr Phe Ala Leu Phe Val Gly Ala Gly Asn Ile Ile Phe Pro Pro Met 
            20                  25                  30          


Val Gly Leu Gln Ala Gly Glu His Val Trp Thr Ala Ala Phe Gly Phe 
        35                  40                  45              


Leu Ile Thr Ala Val Gly Leu Pro Val Leu Thr Val Val Ala Leu Ala 
    50                  55                  60                  


Lys Val Gly Gly Gly Val Asp Ser Leu Ser Thr Pro Ile Gly Lys Val 
65                  70                  75                  80  


Ala Gly Val Leu Leu Ala Thr Val Cys Tyr Leu Ala Val Gly Pro Leu 
                85                  90                  95      


Phe Ala Thr Pro Arg Thr Ala Thr Val Ser Phe Glu Val Gly Ile Ala 
            100                 105                 110         


Pro Leu Thr Gly Asp Ser Ala Leu Pro Leu Phe Ile Tyr Ser Leu Val 
        115                 120                 125             


Tyr Phe Ala Ile Val Ile Leu Val Ser Leu Tyr Pro Gly Lys Leu Leu 
    130                 135                 140                 


Asp Thr Val Gly Asn Phe Leu Ala Pro Leu Lys Ile Ile Ala Leu Val 
145                 150                 155                 160 


Ile Leu Ser Val Ala Ala Ile Val Trp Pro Ala Gly Ser Ile Ser Thr 
                165                 170                 175     


Ala Thr Glu Ala Tyr Gln Asn Ala Ala Phe Ser Asn Gly Phe Val Asn 
            180                 185                 190         


Gly Tyr Leu Thr Met Asp Thr Leu Gly Ala Met Val Phe Gly Ile Val 
        195                 200                 205             


Ile Val Asn Ala Ala Arg Ser Arg Gly Val Thr Glu Ala Arg Leu Leu 
    210                 215                 220                 


Thr Arg Tyr Thr Val Trp Ala Gly Leu Met Ala Gly Val Gly Leu Thr 
225                 230                 235                 240 


Leu Leu Tyr Leu Ala Leu Phe Arg Leu Gly Ser Asp Ser Ala Ser Leu 
                245                 250                 255     


Val Asp Gln Ser Ala Asn Gly Ala Ala Ile Leu His Ala Tyr Val Gln 
            260                 265                 270         


His Thr Phe Gly Gly Gly Gly Ser Phe Leu Leu Ala Ala Leu Ile Phe 
        275                 280                 285             


Ile Ala Cys Leu Val Thr Ala Val Gly Leu Thr Cys Ala Cys Ala Glu 
    290                 295                 300                 


Phe Phe Ala Gln Tyr Val Pro Leu Ser Tyr Arg Thr Leu Val Phe Ile 
305                 310                 315                 320 


Leu Gly Gly Phe Ser Met Val Val Ser Asn Leu Gly Leu Ser Gln Leu 
                325                 330                 335     


Ile Gln Ile Ser Val Pro Val Leu Thr Ala Ile Tyr Pro Pro Cys Ile 
            340                 345                 350         


Ala Leu Val Val Leu Ser Phe Thr Arg Ser Trp Trp His Asn Ser Ser 
        355                 360                 365             


Arg Val Ile Ala Pro Pro Met Phe Ile Ser Leu Leu Phe Gly Ile Leu 
    370                 375                 380                 


Asp Gly Ile Lys Ala Ser Ala Phe Ser Asp Ile Leu Pro Ser Trp Ala 
385                 390                 395                 400 


Gln Arg Leu Pro Leu Ala Glu Gln Gly Leu Ala Trp Leu Met Pro Thr 
                405                 410                 415     


Val Val Met Val Val Leu Ala Ile Ile Trp Asp Arg Ala Ala Gly Arg 
            420                 425                 430         


Gln Val Thr Ser Ser Ala His 
        435                 


<210>  32
<211>  308
<212>  PRT
<213>  Escherichia coli

<400>  32

Met Thr His Gln Leu Arg Ser Arg Asp Ile Ile Ala Leu Gly Phe Met 
1               5                   10                  15      


Thr Phe Ala Leu Phe Val Gly Ala Gly Asn Ile Ile Phe Pro Pro Met 
            20                  25                  30          


Val Gly Leu Gln Ala Gly Glu His Val Trp Thr Ala Ala Phe Gly Phe 
        35                  40                  45              


Leu Ile Thr Ala Val Gly Leu Pro Val Leu Thr Val Val Ala Leu Ala 
    50                  55                  60                  


Lys Val Gly Gly Gly Val Asp Ser Leu Ser Thr Pro Ile Gly Lys Val 
65                  70                  75                  80  


Ala Gly Val Leu Leu Ala Thr Val Cys Tyr Leu Ala Val Gly Pro Leu 
                85                  90                  95      


Phe Ala Thr Pro Arg Thr Ala Thr Val Ser Phe Glu Val Gly Ile Ala 
            100                 105                 110         


Pro Leu Thr Gly Asp Ser Ala Leu Pro Leu Phe Ile Tyr Ser Leu Val 
        115                 120                 125             


Tyr Phe Ala Ile Val Ile Leu Val Ser Leu Tyr Pro Gly Lys Leu Leu 
    130                 135                 140                 


Asp Thr Val Gly Asn Phe Leu Ala Pro Leu Lys Ile Ile Ala Leu Val 
145                 150                 155                 160 


Ile Leu Ser Val Ala Ala Ile Val Trp Pro Ala Gly Ser Ile Ser Thr 
                165                 170                 175     


Ala Thr Glu Ala Tyr Gln Asn Ala Ala Phe Ser Asn Gly Phe Val Asn 
            180                 185                 190         


Gly Tyr Leu Thr Met Asp Thr Leu Gly Ala Met Val Phe Gly Ile Val 
        195                 200                 205             


Ile Val Asn Ala Ala Arg Ser Arg Gly Val Thr Glu Ala Arg Leu Leu 
    210                 215                 220                 


Thr Arg Tyr Thr Val Trp Ala Gly Leu Met Ala Gly Val Gly Leu Thr 
225                 230                 235                 240 


Leu Leu Tyr Leu Ala Leu Phe Arg Leu Gly Ser Asp Ser Ala Ser Leu 
                245                 250                 255     


Val Asp Gln Ser Ala Asn Gly Ala Ala Ile Leu His Ala Tyr Val Gln 
            260                 265                 270         


His Thr Phe Gly Gly Gly Gly Ser Phe Leu Leu Ala Ala Leu Ile Phe 
        275                 280                 285             


Ile Ala Cys Leu Val Thr Ala Val Gly Leu Thr Cys Ala Cys Ala Glu 
    290                 295                 300                 


Phe Phe Ala Gln 
305             


<210>  33
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  33
gcgctgttat tagttcgtta ctggaagtcc agtcaccttg tcaggagtat tatcgtggtg       60

taggctggag ctgcttcg                                                     78


<210>  34
<211>  73
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  34
cgcccatccg ttgcagatgg gcgagtaaga agtattagtc acactggacc atatgaatat       60

cctccttagt tcc                                                          73


<210>  35
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  35
cgctttcggg cggcgcttcc tccgttttaa cgcgatgtat ttcctatggt gtaggctgga       60

gctgcttcg                                                               69


<210>  36
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  36
ggcctcgcaa aacgaggcct ttggagagcg attaatcgca ggcaaccata tgaatatcct       60

ccttagttcc                                                              70


<210>  37
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  37
cgttccgctc cacttcactg aacggcaatc cgagggtgtg gatatggtgt aggctggagc       60

tgcttcg                                                                 67


<210>  38
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  38
gtgcacccaa ggatgaaagc tgacagcaat gtcagccgca gaccaccata tgaatatcct       60

ccttagttcc                                                              70


<210>  39
<211>  71
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  39
gttagctgag tcaggagatg cggatgttaa agcgtgaaat gaacattgcc gtgtaggctg       60

gagctgcttc g                                                            71


<210>  40
<211>  73
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  40
caacgagcac attgacagca aatcaccgtt tcgcttatgc gtaaaccggc atatgaatat       60

cctccttagt tcc                                                          73


<210>  41
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  41
gcgctgttat tagttcgtta ctggaagtcc                                        30


<210>  42
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  42
cgcccatccg ttgcagatgg gc                                                22


<210>  43
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  43
cgctttcggg cggcgcttcc tc                                                22


<210>  44
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  44
ggcctcgcaa aacgaggcct ttgg                                              24


<210>  45
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  45
cgttccgctc cacttcactg aacgg                                             25


<210>  46
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  46
gtgcacccaa ggatgaaagc tgacagc                                           27


<210>  47
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  47
gttagctgag tcaggagatg cggatgtt                                          28


<210>  48
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  48
caacgagcac attgacagca aatcaccg                                          28


<210>  49
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  49
ggcccatggc aaaggtatcg ctggag                                            26


<210>  50
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  50
attgcggccg cttagtacag cagacgggcg cga                                    33


<210>  51
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  51
ggcccatggc taacattacc tggtgcg                                           27


<210>  52
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  52
gccaagcttt tattacttct gattcaggct gcc                                    33


<210>  53
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  53
gccttaatta attattactt ctgattcagg ctgcc                                  35


<210>  54
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  54
ggccatatga tggctcaaat cttcaatttt agttctgg                               38


<210>  55
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  55
gccttaatta atcattaacc gtgacggcgt tcgaac                                 36


<210>  56
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  56
ccgcatatgt cgcgaaaaga tggggtg                                           27


<210>  57
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  57
gccttaatta atgatgatga tgatgatgac ttcccacctt taccgcttta cgcc             54


<210>  58
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  58
ccgccatggc gcgaaaagat ggggtg                                            26


<210>  59
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  59
cgagcagggc gtcgctatcg ccgcgcaata                                        30


<210>  60
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  60
tattgcgcgg cgatagcgac gccctgctcg                                        30


<210>  61
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  61
ctgatcacat cgctgaagct cgtccgggcg tgc                                    33


<210>  62
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  62
gcacgcccgg acgagcttca gcgatgtgca tcag                                   34


<210>  63
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  63
caaggtatta ttctgtcatg gcggtggtcg cg                                     32


<210>  64
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  64
cgcgaccacc gccatgacag aataatacct tg                                     32


<210>  65
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  65
atgcgagtgt tgaagttcgg cg                                                22


<210>  66
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  66
tcagactcct aacttccatg agaggg                                            26


<210>  67
<211>  73
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  67
atgcgagtgt tgaagttcgg cggtacatca gtggcaaatg cagaacgttt aaaatgagac       60

gttgatcggc acg                                                          73


<210>  68
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  68
tcagactcct aacttccatg agagggtacg tagcagatca gcaaagacac caaagggaaa       60

actgtccata tgcac                                                        75


<210>  69
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  69
gcttgacttc ttccataaca acgtaagtgc gcgtcccgtt aaccccaggc agacgcagca       60

gggtttc                                                                 67


<210>  70
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  70
ccaaccggct gaatcatgaa ttcttgaatg tcgagattat tatcagcgtg ctcaccaccg       60

ttgatgatg                                                               69


<210>  71
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  71
ctcaacttgc aggtagaaga tgaaacgagg aaagagaggc tccgccgcgg cgaagtggtc       60

ggc                                                                     63


<210>  72
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  72
cagctcaatc cccacgaaag ctaatacggc aacttgaaaa ccggcaaaga agccacttaa       60

acctttc                                                                 67


<210>  73
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  73
gcatcatggt tgcgcgtggc gacctcggcg tttagtgacc ctaaatcttc gcccagaaga       60

tgatga                                                                  66


<210>  74
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  74
gatacgacgt ttgtgcgtaa tttctgagag gagattattt tggtccataa actgagacag       60

ctg                                                                     63


<210>  75
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  75
ctcgtaaggc atttagcggt ggtaatggtt atcattaggc tattaaactt tgatgttaaa       60

tg                                                                      62


<210>  76
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  76
ggtgagatta atcggaccaa cggagaaggc attgtgttgg tatgcaaacg tcacgttacg       60

cagctccagc                                                              70


<210>  77
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  77
gagatggtat caccagtgcg gagattaaat cttagtatct gagaagggga aacgtagatg       60

tcatcag                                                                 67


<210>  78
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  78
tcgtcggcag cgtcagatgt gtataagaga cagcggtgat ttcgactacc tgttg            55


<210>  79
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  79
gtctcgtggg ctcggagatg tgtataagag acaggcgcgt cttaataacc agacgat          57


<210>  80
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  80
tcgtcggcag cgtcagatgt gtataagaga caggctgtac gagcacatcg ctgaac           56


<210>  81
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  81
gtctcgtggg ctcggagatg tgtataagag acagcccatg cggatggctt ctttcac          57


<210>  82
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  82
tcgtcggcag cgtcagatgt gtataagaga caggacagtc tggcgacgtg gttgct           56


<210>  83
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  83
gtctcgtggg ctcggagatg tgtataagag acagtatcga caagacaact cggcagcg         58


<210>  84
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  84
tcgtcggcag cgtcagatgt gtataagaga cagggaagcg tcattcgcgc atttg            55


<210>  85
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  85
gtctcgtggg ctcggagatg tgtataagag acaggttaat cgcgcgtggc agtg             54


<210>  86
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  86
tcgtcggcag cgtcagatgt gtataagaga cagggcctca acaacttcga cga              53


<210>  87
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  87
gtctcgtggg ctcggagatg tgtataagag acaggaatcc agcatctggg tcgc             54


<210>  88
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  88
tcgtcggcag cgtcagatgt gtataagaga cagcaacgcc aagccgattt ccg              53


<210>  89
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  89
gtctcgtggg ctcggagatg tgtataagag acaggtctcg aacttcgaag cctgc            55


<210>  90
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  90
tcgtcggcag cgtcagatgt gtataagaga caggctggta gaagctcaac ggac             54


<210>  91
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  91
gtctcgtggg ctcggagatg tgtataagag acagtgctgc ggcatcaaaa actcg            55


<210>  92
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  92
tcgtcggcag cgtcagatgt gtataagaga caggcctttc aaagcagagt ttccgc           56


<210>  93
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  93
gtctcgtggg ctcggagatg tgtataagag acagctaccg ttgccgccaa tcag             54


<210>  94
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  94
tcgtcggcag cgtcagatgt gtataagaga caggcaggat ggatttggtt tcctcc           56


<210>  95
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  95
gtctcgtggg ctcggagatg tgtataagag acaggcagcg caaaatagcg ttcacc           56


<210>  96
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  96
gcgccatggg agtgttgaag ttcggcg                                           27


<210>  97
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  97
gccaagcttt cagactccta acttccatga gaggg                                  35


<210>  98
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  n is a, c, g, or t

<400>  98
cgcagaaact gatgctmnnt tcggaagatg attgcg                                 36


<210>  99
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  n is a, c, g, or t

<400>  99
cgcagaaact gatgctmnnt tcggaagatg attgcg                                 36


<210>  100
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  n is a, c, g, or t

<400>  100
caatcatctt ccgaatacnn katcagtttc tgcgttcc                               38


<210>  101
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  n is a, c, g, or t

<400>  101
ggaacgcaga aactgatmnn gtattcggaa gatgattg                               38


<210>  102
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  n is a, c, g, or t

<400>  102
ccgaatacag catcnnkttc tgcgttccac                                        30


<210>  103
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer


<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  n is a, c, g, or t

<400>  103
gtggaacgca gaamnngatg ctgtattcgg                                        30


<210>  104
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  104
cacacagtcg ctttgtggaa cgcagaaact aatccgatac tccgaagatg attgcgtaat       60

cagcacc                                                                 67


