SEQUENCE LISTING

<110>  CELLECTIS;RINAT

<120>  CLL1-SPECIFIC MULTI-CHAIN CHIMERIC ANTIGEN RECEPTOR 

<130>  P81504848PCT00

<150>  PA201570044
<151>  2015-01-26

<160> 123
<170>  PatentIn version 3.5


<210>  1

<211>  
<212>  PRT
<213>  homo sapiens

<220>
<223>  Fc Receptor for IgE, alpha chain, signal peptide

<400>  1
Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala 
            20                  25  


<210>  2

<211>  45
<212>  PRT
<213>  homo sapiens

<220>
<223>  CD8a-hinge

<400>  2
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  3

<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker for VH and VL fragments of the scFv

<400>  3
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  4

<211>  52
<212>  PRT
<213>  homo sapiens

<220>
<223>  Fc Receptor for IgE, alpha chain, transmembrane and intracellular domain

<400>  4
Phe Phe Ile Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly 
1               5                   10                  15      


Leu Phe Ile Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys 
            20                  25                  30          


Arg Thr Arg Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn 
        35                  40                  45              


Pro Lys Asn Asn 
    50          


<210>  5

<211>  215
<212>  PRT
<213>  homo sapiens

<220>
<223>  Fc Receptor for IgE, beta chain, without ITAM

<400>  5
Met Asp Thr Glu Ser Asn Arg Arg Ala Asn Leu Ala Leu Pro Gln Glu 
1               5                   10                  15      


Pro Ser Ser Val Pro Ala Phe Glu Val Leu Glu Ile Ser Pro Gln Glu 
            20                  25                  30          


Val Ser Ser Gly Arg Leu Leu Lys Ser Ala Ser Ser Pro Pro Leu His 
        35                  40                  45              


Thr Trp Leu Thr Val Leu Lys Lys Glu Gln Glu Phe Leu Gly Val Thr 
    50                  55                  60                  


Gln Ile Leu Thr Ala Met Ile Cys Leu Cys Phe Gly Thr Val Val Cys 
65                  70                  75                  80  


Ser Val Leu Asp Ile Ser His Ile Glu Gly Asp Ile Phe Ser Ser Phe 
                85                  90                  95      


Lys Ala Gly Tyr Pro Phe Trp Gly Ala Ile Phe Phe Ser Ile Ser Gly 
            100                 105                 110         


Met Leu Ser Ile Ile Ser Glu Arg Arg Asn Ala Thr Tyr Leu Val Arg 
        115                 120                 125             


Gly Ser Leu Gly Ala Asn Thr Ala Ser Ser Ile Ala Gly Gly Thr Gly 
    130                 135                 140                 


Ile Thr Ile Leu Ile Ile Asn Leu Lys Lys Ser Leu Ala Tyr Ile His 
145                 150                 155                 160 


Ile His Ser Cys Gln Lys Phe Phe Glu Thr Lys Cys Phe Met Ala Ser 
                165                 170                 175     


Phe Ser Thr Glu Ile Val Val Met Met Leu Phe Leu Thr Ile Leu Gly 
            180                 185                 190         


Leu Gly Ser Ala Val Ser Leu Thr Ile Cys Gly Ala Gly Glu Glu Leu 
        195                 200                 205             


Lys Gly Asn Lys Val Pro Glu 
    210                 215 


<210>  6

<211>  42
<212>  PRT
<213>  homo sapiens

<220>
<223>  41BB Intracellular domain

<400>  6
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  7

<211>  41
<212>  PRT
<213>  homo sapiens

<220>
<223>  CD28 Intracellular domain

<400>  7
Arg Ser Lys Arg Ser Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  8

<211>  18
<212>  PRT
<213>  homo sapiens

<220>
<223>  Fc Receptor for IgE, gamma chain, signal peptide

<400>  8
Met Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala 
        


<210>  9

<211>  43
<212>  PRT
<213>  homo sapiens

<220>
<223>  Fc Receptor for IgE, gamma chain, without ITAM

<400>  9
Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu Phe Leu 
1               5                   10                  15      


Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile Gln Val 
            20                  25                  30          


Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser 
        35                  40              


<210>  10

<211>  112
<212>  PRT
<213>  homo sapiens

<220>
<223>  CD3z intracellular domain

<400>  10
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         






<210>  11

<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  GSG-P2A ribosomal skip peptide

<400>  11
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  12

<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  GSG-T2A ribosomal skip peptide

<400>  12
Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  13

<211>  115
<212>  PRT
<213>  artificial sequence

<220>
<223>  SC02-357 heavy chain variable region

<400>  13
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Val Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Pro Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Ser 
                85                  90                  95      


Ser Ser Gly Gly Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  14

<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  SC02-378 heavy chain variable region

<400>  14
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Val Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Pro Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ser Ser Gly Gly Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  15

<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  SC02-161 heavy chain variable region

<400>  15
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Val Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Pro Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Thr Thr Ala Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  16

<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  SC02-357 & SC02-378 & SC02-161 light chain variable region

<400>  16
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  17

<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  M26 heavy chain variable region

<400>  17
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Phe Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Asn Pro Tyr Asn Asp Gly Ser Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Asp Gly Tyr Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  18

<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  M26 light chain variable region

<400>  18
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Thr Gln Glu Leu Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Asn Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  19

<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  M31 heavy chain variable region

<400>  19
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Ile Tyr Phe Asp Asn Asp Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Lys Val Ser Ser 
        115                 120 


<210>  20

<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  M31 light chain variable region

<400>  20
Thr Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Tyr Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  21

<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  G4 heavy chain variable region

<400>  21
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Glu Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Pro Ile Asn Pro Tyr Asn Asp Gly Thr Ile Tyr Asn Pro Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ala Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Asp Asp Pro Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Asp Asp Tyr Asp Asp Tyr Thr Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  22

<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  G4 light chain variable region

<400>  22
Glu Ile Gln Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser His Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Leu Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Lys Thr Leu Leu Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  23

<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  M22  heavy chain variable region

<400>  23
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Thr Glu Thr His Tyr Asn Gln Gln Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Tyr Tyr Gly Asn Pro Ser Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  24

<211>  113
<212>  PRT
<213>  artificial sequence

<220>
<223>  M22 light chain variable region

<400>  24
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Asn Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  25

<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  M29  heavy chain variable region

<400>  25
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Val Met Tyr Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Tyr Asp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  26

<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  M29 light chain variable region

<400>  26
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Tyr Leu Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  27

<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  M2 heavy chain variable region

<400>  27
Glu Val Gln Leu Arg Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Phe Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Asp Gly Tyr Tyr Asp Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  28

<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  M2 light chain variable region

<400>  28
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Val Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Glu Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  29

<211>  115
<212>  PRT
<213>  artificial sequence

<220>
<223>  M5 heavy chain variable region

<400>  29
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Lys Gly Asp Thr Ala Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Ile Thr Ser Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Leu Thr Gly Arg Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  30

<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  M5 light chain variable region

<400>  30
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  31

<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  G12 heavy chain variable region

<400>  31
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Pro Ser Ser 
            20                  25                  30          


Asn Ile His Trp Leu Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Tyr Asn Trp His Phe Asp Val Trp Gly Ala Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  32

<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  G12 light chain variable region

<400>  32
Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Gly Tyr 
            20                  25                  30          


Gly Asp Ile Phe Met Leu Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Phe Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  33

<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  21.26 heavy chain variable region

<400>  33
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Ser Ser Gly Ser Thr Ser Tyr Asn Glu Lys Val 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Asp Tyr Tyr Tyr Gly Thr Gly Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  34

<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  21.26 light chain variable region

<400>  34
Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Ile Asn Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Phe 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Arg Ser Asp Arg Ala Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105     


<210>  35

<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  1075.7 heavy chain variable region

<400>  35
Asp Ile Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Ala 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Asp Gly Arg Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Gly Asp Tyr Asp Val Gly Asn Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  36

<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  1075.7 light chain variable region

<400>  36
Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Asn Val Ile Ser Ser 
            20                  25                  30          


Tyr Val His Trp Tyr Gln Gln Arg Ser Gly Ala Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Gly Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105         


<210>  37

<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of SC02-357 heavy chain variable region

<400>  37
Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser 
1               5                   10  


<210>  38

<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 of SC02-357 heavy chain variable region

<400>  38
Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro Asp Tyr 
1               5                   10              


<210>  39

<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of SC02-357 heavy chain variable region

<400>  39
Lys Val Ser Thr Gly Gly Phe Phe Asp Tyr 
1               5                   10  


<210>  40

<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of SC02-378 heavy chain variable region

<400>  40
Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser 
1               5                   10  


<210>  41

<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 of SC02-378 heavy chain variable region

<400>  41
Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro Asn Tyr 
1               5                   10              


<210>  42

<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of SC02-378 heavy chain variable region

<400>  42
Arg Ser Ser Ser Gly Gly Phe Phe Asp Tyr 
1               5                   10  


<210>  43

<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of SC02-161 heavy chain variable region

<400>  43
Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser 
1               5                   10  


<210>  44

<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 of SC02-161 heavy chain variable region

<400>  44
Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro Asn Tyr 
1               5                   10              


<210>  45

<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of SC02-161 heavy chain variable region

<400>  45
Arg Gln Thr Thr Ala Gly Ser Phe Asp Tyr 
1               5                   10  


<210>  46

<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of SC02-357 & SC02-378 & SC02-161 light chain variable region

<400>  46
Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5               


<210>  47

<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 of SC02-357 & SC02-378 & SC02-161 light chain variable region

<400>  47
Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
1               5                   10      


<210>  48

<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of SC02-357 & SC02-378 & SC02-161 light chain variable region

<400>  48
Gln Gln Ser Tyr Ser Thr Pro Pro 
1               5               


<210>  49

<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of M26 heavy chain variable region

<400>  49
Gly Tyr Thr Phe Thr Ser Tyr Phe Ile His 
1               5                   10  


<210>  50

<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 of M26 heavy chain variable region

<400>  50
Trp Ile Gly Phe Ile Asn Pro Tyr Asn Asp Gly Ser Lys Tyr 
1               5                   10                  


<210>  51

<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of M26 heavy chain variable region

<400>  51
Thr Arg Asp Asp Gly Tyr Tyr Gly Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  52

<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of M26 light chain variable region

<400>  52
Gln Glu Leu Ser Gly Tyr Leu Ser 
1               5               


<210>  53

<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 of M26 light chain variable region

<400>  53
Arg Leu Ile Tyr Ala Ala Ser Thr Leu Asp Ser 
1               5                   10      


<210>  54

<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of M26 light chain variable region

<400>  54
Leu Gln Tyr Ala Ile Tyr Pro Tyr 
1               5               


<210>  55

<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of M31 heavy chain variable region

<400>  55
Gly Tyr Thr Phe Thr Ser Tyr Val Met His 
1               5                   10  


<210>  56

<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 of M31 heavy chain variable region

<400>  56
Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr 
1               5                   10                  


<210>  57

<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of M31 heavy chain variable region

<400>  57
Ala Arg Pro Ile Tyr Phe Asp Asn Asp Tyr 
1               5                   10  


<210>  58

<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of M31 light chain variable region

<400>  58
Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe Met His 
1               5                   10          


<210>  59

<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 of M31 light chain variable region

<400>  59
Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser 
1               5                   10      


<210>  60

<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of M31 light chain variable region

<400>  60
Gln Gln Asn Asn Tyr Asp Pro Trp 
1               5               


<210>  61

<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of G4 heavy chain variable region

<400>  61
Gln Gln Asn Asn Tyr Asp Pro Trp 
1               5               


<210>  62

<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 of G4 heavy chain variable region

<400>  62
Trp Ile Gly Pro Ile Asn Pro Tyr Asn Asp Gly Thr Ile Tyr 
1               5                   10                  


<210>  63

<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of G4 heavy chain variable region

<400>  63
Ala Arg Thr Asp Asp Tyr Asp Asp Tyr Thr Met Asp Tyr 
1               5                   10              


<210>  64

<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of G4 light chain variable region

<400>  64
His Asp Ile Ser Asn Tyr Leu Asn 
1               5               


<210>  65

<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 of G4 light chain variable region

<400>  65
Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 
1               5                   10      


<210>  66

<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of G4 light chain variable region

<400>  66
Gln Gln Gly Lys Thr Leu Leu Trp 
1               5               


<210>  67

<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of M22 heavy chain variable region

<400>  67
Gly Tyr Thr Phe Thr Arg Tyr Trp Met His 
1               5                   10  


<210>  68

<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 of M22 heavy chain variable region

<400>  68
Trp Ile Gly Asn Ile Asp Pro Ser Asp Thr Glu Thr His Tyr 
1               5                   10                  


<210>  69

<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of M22 heavy chain variable region

<400>  69
Ala Ile Tyr Tyr Gly Asn Pro Ser Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  70

<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of M22 light chain variable region

<400>  70
Gln Asn Leu Leu Asn Ser Gly Asn Gln Lys Lys Tyr Leu Asn 
1               5                   10                  


<210>  71

<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 of M22 light chain variable region

<400>  71
Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser 
1               5                   10      


<210>  72

<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of M22 light chain variable region

<400>  72
Gln Asn Asp Tyr Ser Tyr Pro Phe 
1               5               


<210>  73

<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of M29 heavy chain variable region

<400>  73
Gly Tyr Ile Phe Thr Ser Tyr Val Met Tyr 
1               5                   10  


<210>  74

<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 of M29 heavy chain variable region

<400>  74
Trp Ile Gly Tyr Ile Asn Pro Tyr 
1               5               


<210>  75

<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of M29 heavy chain variable region

<400>  75
Ala Arg Tyr Tyr Asp Tyr Asp Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210>  76

<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of M29 light chain variable region

<400>  76
Gln Asp Ile Asn Lys Tyr Ile Ala 
1               5               


<210>  77

<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 of M29 light chain variable region

<400>  77
Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro 
1               5                   10      


<210>  78

<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of M29 light chain variable region

<400>  78
Leu Gln Tyr Asp Tyr Leu Trp 
1               5           


<210>  79

<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of M2 heavy chain variable region

<400>  79
Gly Tyr Thr Phe Thr Ser Tyr Phe Met His 
1               5                   10  


<210>  80

<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 of M2 heavy chain variable region

<400>  80
Trp Ile Gly Phe Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr 
1               5                   10                  


<210>  81

<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of M2 heavy chain variable region

<400>  81
Thr Arg Asp Asp Gly Tyr Tyr Asp Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  82

<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of M2 light chain variable region

<400>  82
Gln Glu Ile Ser Val Tyr Leu Ser 
1               5               


<210>  83

<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 of M2 light chain variable region

<400>  83
Arg Leu Ile Tyr Ala Ala Ser Thr Leu Asp Ser 
1               5                   10      


<210>  84

<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of M2 light chain variable region

<400>  84
Leu Gln Tyr Ala Ser Tyr Pro Tyr 
1               5               


<210>  85

<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of M5 heavy chain variable region

<400>  85
Gly Phe Asn Ile Lys Asp Asp Tyr Ile His 
1               5                   10  


<210>  86

<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 of M5 heavy chain variable region

<400>  86
Trp Ile Gly Trp Ile Asp Pro Glu Lys Gly Asp Thr Ala Tyr Ala Ser 
1               5                   10                  15      


<210>  87

<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of M5 heavy chain variable region

<400>  87
Thr Leu Thr Gly Arg Phe Asp Tyr 
1               5               


<210>  88

<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of M5 light chain variable region

<400>  88
Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Asn Leu Ala 
1               5                   10                  


<210>  89

<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 of M5 light chain variable region

<400>  89
Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser 
1               5                   10      


<210>  90

<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of M5 light chain variable region

<400>  90
Gln Gln Tyr Tyr Ser Tyr Arg 
1               5           


<210>  91

<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of G12 heavy chain variable region

<400>  91
Gly Tyr Thr Phe Pro Ser Ser Asn Ile His 
1               5                   10  


<210>  92

<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 of G12 heavy chain variable region

<400>  92
Trp Ile Gly Val Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr 
1               5                   10                  


<210>  93

<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of G12 heavy chain variable region

<400>  93
Ala Ile Tyr Phe Val Tyr Asn Trp His Phe Asp Val 
1               5                   10          


<210>  94

<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of G12 light chain variable region

<400>  94
Glu Ser Val Asp Gly Tyr Gly Asp Ile Phe Met Leu 
1               5                   10          


<210>  95

<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 of G12 light chain variable region

<400>  95
Leu Leu Ile Tyr Phe Ala Ser Asn Leu Glu Ser 
1               5                   10      


<210>  96

<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of G12 light chain variable region

<400>  96
Gln Gln Asn Asn Glu Asp Pro Tyr 
1               5               


<210>  97

<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of 21.26 heavy chain variable region

<400>  97
Gly Tyr Thr Phe Thr Arg Tyr Trp Met His 
1               5                   10  


<210>  98

<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 of 21.26 heavy chain variable region

<400>  98
Met Ile His Pro Ser Ser Gly Ser Thr Ser Tyr Asn Glu Lys Val Lys 
1               5                   10                  15      






<210>  99

<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of 21.26 heavy chain variable region

<400>  99
Arg Asp Gly Asp Tyr Tyr Tyr Gly Thr Gly Asp Tyr 
1               5                   10          


<210>  100

<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of 21.26 light chain variable region

<400>  100
Arg Ala Ser Ser Ser Ile Asn Tyr Met His 
1               5                   10  


<210>  101

<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 of 21.26 light chain variable region

<400>  101
Pro Trp Ile Phe Ala Thr Ser Asn Leu Ala Ser 
1               5                   10      


<210>  102

<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of 21.26 light chain variable region

<400>  102
Gln Gln Trp Arg Ser Asp Arg Ala Leu Thr 
1               5                   10  


<210>  103

<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of 1075.7 heavy chain variable region

<400>  103
Gly Tyr Ser Ile Thr Ser Ala Tyr Tyr Trp Asn 
1               5                   10      


<210>  104

<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 of 1075.7 heavy chain variable region

<400>  104
Tyr Ile Ser Tyr Asp Gly Arg Asn Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      






<210>  105

<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of 1075.7 heavy chain variable region

<400>  105
Ala Lys Glu Gly Asp Tyr Asp Val Gly Asn Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  15      






<210>  106

<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 of 1075.7 light chain variable region

<400>  106
Arg Ala Ser Ser Asn Val Ile Ser Ser Tyr Val His 
1               5                   10          


<210>  107

<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 of 1075.7 light chain variable region

<400>  107
Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
1               5                   10      


<210>  108

<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 of 1075.7 light chain variable region

<400>  108
Gln Gln Tyr Ser Gly Tyr Pro Leu Thr 
1               5                   


<210>  109

<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD20 mimotope

<400>  109
Cys Pro Tyr Ser Asn Pro Ser Leu Cys Ser 
1               5                   10  


<210>  110

<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  Epitope for palivizumab

<400>  110
Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Lys Leu Met Ser Asn Asn 
            20                  


<210>  111

<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Mimotope 1 for cetuximab

<400>  111
Cys Gln Phe Asp Leu Ser Thr Arg Arg Leu Lys Cys 
1               5                   10          


<210>  112

<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Mimotope 2 for cetuximab

<400>  112
Cys Gln Tyr Asn Leu Ser Ser Arg Ala Leu Lys Cys 
1               5                   10          


<210>  113

<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Mimotope 3 for cetuximab

<400>  113
Cys Val Trp Gln Arg Trp Gln Lys Ser Tyr Val Cys 
1               5                   10          


<210>  114

<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Mimotope 4 for cetuximab

<400>  114
Cys Met Trp Asp Arg Phe Ser Arg Trp Tyr Lys Cys 
1               5                   10          


<210>  115

<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  Epitope 1 for nivolumab

<400>  115
Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp 
1               5                   10                  15      


Lys Leu Ala Ala Phe Pro Glu Asp Arg 
            20                  25  


<210>  116

<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  Epitope 2 for nivolumab

<400>  116
Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln 
1               5                   10                  15      


Ile Lys Glu 
            


<210>  117

<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  Epitope 1 for CD34

<400>  117
Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu Thr 
1               5                   10                  


<210>  118

<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  Epitope 2 for CD34

<400>  118
Asn Thr Asn Ser Ser Val Gln Ser Gln Thr Ser Val Ile Ser 
1               5                   10                  



<210>  119

<211>  49
<212>  DNA
<213>  artificial sequence

<220>
<223>  Target TALEN TRAC_T01

<400>  119
ttgtcccaca gatatccaga accctgaccc tgccgtgtac cagctgaga                 49




<210>  120

<211>  530
<212>  PRT
<213>  artificial sequence

<220>
<223>  TAL binding domain  TRAC_T01-L

<400>  120
Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            20                  25                  30          


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
        35                  40                  45              


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    50                  55                  60                  


Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn 
65                  70                  75                  80  


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                85                  90                  95      


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
            100                 105                 110         


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        115                 120                 125             


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
    130                 135                 140                 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
145                 150                 155                 160 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
                165                 170                 175     


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
            180                 185                 190         


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
        195                 200                 205             


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
    210                 215                 220                 


Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
225                 230                 235                 240 


Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
                245                 250                 255     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
            260                 265                 270         


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
        275                 280                 285             


Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala 
    290                 295                 300                 


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
305                 310                 315                 320 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                325                 330                 335     


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
            340                 345                 350         


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val 
        355                 360                 365             


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
    370                 375                 380                 


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
385                 390                 395                 400 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
                405                 410                 415     


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala 
            420                 425                 430         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 
        435                 440                 445             


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
    450                 455                 460                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
465                 470                 475                 480 


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
                485                 490                 495     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            500                 505                 510         


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 
        515                 520                 525             


Leu Glu 
    530 


<210>  121

<211>  530
<212>  PRT
<213>  artificial sequence

<220>
<223>  TAL binding domain TRAC_T01-R

<400>  121
Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            20                  25                  30          


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
        35                  40                  45              


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    50                  55                  60                  


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His 
65                  70                  75                  80  


Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                85                  90                  95      


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
            100                 105                 110         


Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu 
        115                 120                 125             


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
    130                 135                 140                 


Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
145                 150                 155                 160 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
                165                 170                 175     


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
            180                 185                 190         


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
        195                 200                 205             


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 
    210                 215                 220                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
225                 230                 235                 240 


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 
                245                 250                 255     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
            260                 265                 270         


Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 
        275                 280                 285             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
    290                 295                 300                 


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
305                 310                 315                 320 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                325                 330                 335     


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
            340                 345                 350         


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val 
        355                 360                 365             


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
    370                 375                 380                 


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
385                 390                 395                 400 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
                405                 410                 415     


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala 
            420                 425                 430         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
        435                 440                 445             


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
    450                 455                 460                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
465                 470                 475                 480 


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 
                485                 490                 495     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            500                 505                 510         


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 
        515                 520                 525             


Leu Glu 
    530 



<210>  122

<211>  2814
<212>  DNA
<213>  artificial sequence

<220>
<223>  polynucleotide encoding  TRAC_T01-L TALEN

<400>  122
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac     60
gctatcgata tcgccgatct acgcacgctc ggctacagcc agcagcaaca ggagaagatc    120
aaaccgaagg ttcgttcgac agtggcgcag caccacgagg cactggtcgg ccacgggttt    180
acacacgcgc acatcgttgc gttaagccaa cacccggcag cgttagggac cgtcgctgtc    240
aagtatcagg acatgatcgc agcgttgcca gaggcgacac acgaagcgat cgttggcgtc    300
ggcaaacagt ggtccggcgc acgcgctctg gaggccttgc tcacggtggc gggagagttg    360
agaggtccac cgttacagtt ggacacaggc caacttctca agattgcaaa acgtggcggc    420
gtgaccgcag tggaggcagt gcatgcatgg cgcaatgcac tgacgggtgc cccgctcaac    480
ttgacccccc agcaggtggt ggccatcgcc agcaatggcg gtggcaagca ggcgctggag    540
acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg    600
gtggccatcg ccagcaataa tggtggcaag caggcgctgg agacggtcca gcggctgttg    660
ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat    720
ggcggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc    780
cacggcttga ccccggagca ggtggtggcc atcgccagcc acgatggcgg caagcaggcg    840
ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccggag    900
caggtggtgg ccatcgccag ccacgatggc ggcaagcagg cgctggagac ggtccagcgg    960
ctgttgccgg tgctgtgcca ggcccacggc ttgaccccgg agcaggtggt ggccatcgcc   1020
agccacgatg gcggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc   1080
caggcccacg gcttgacccc ggagcaggtg gtggccatcg ccagcaatat tggtggcaag   1140
caggcgctgg agacggtgca ggcgctgttg ccggtgctgt gccaggccca cggcttgacc   1200
ccggagcagg tggtggccat cgccagccac gatggcggca agcaggcgct ggagacggtc   1260
cagcggctgt tgccggtgct gtgccaggcc cacggcttga ccccggagca ggtggtggcc   1320
atcgccagca atattggtgg caagcaggcg ctggagacgg tgcaggcgct gttgccggtg   1380
ctgtgccagg cccacggctt gaccccccag caggtggtgg ccatcgccag caataatggt   1440
ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc   1500
ttgaccccgg agcaggtggt ggccatcgcc agcaatattg gtggcaagca ggcgctggag   1560
acggtgcagg cgctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg   1620
gtggccatcg ccagcaatgg cggtggcaag caggcgctgg agacggtcca gcggctgttg   1680
ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagcaat   1740
attggtggca agcaggcgct ggagacggtg caggcgctgt tgccggtgct gtgccaggcc   1800
cacggcttga ccccccagca ggtggtggcc atcgccagca atggcggtgg caagcaggcg   1860
ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccggag   1920
caggtggtgg ccatcgccag ccacgatggc ggcaagcagg cgctggagac ggtccagcgg   1980
ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc agcaggtggt ggccatcgcc   2040
agcaatggcg gcggcaggcc ggcgctggag agcattgttg cccagttatc tcgccctgat   2100
ccggcgttgg ccgcgttgac caacgaccac ctcgtcgcct tggcctgcct cggcgggcgt   2160
cctgcgctgg atgcagtgaa aaagggattg ggggatccta tcagccgttc ccagctggtg   2220
aagtccgagc tggaggagaa gaaatccgag ttgaggcaca agctgaagta cgtgccccac   2280
gagtacatcg agctgatcga gatcgcccgg aacagcaccc aggaccgtat cctggagatg   2340
aaggtgatgg agttcttcat gaaggtgtac ggctacaggg gcaagcacct gggcggctcc   2400
aggaagcccg acggcgccat ctacaccgtg ggctccccca tcgactacgg cgtgatcgtg   2460
gacaccaagg cctactccgg cggctacaac ctgcccatcg gccaggccga cgaaatgcag   2520
aggtacgtgg aggagaacca gaccaggaac aagcacatca accccaacga gtggtggaag   2580
gtgtacccct ccagcgtgac cgagttcaag ttcctgttcg tgtccggcca cttcaagggc   2640
aactacaagg cccagctgac caggctgaac cacatcacca actgcaacgg cgccgtgctg   2700
tccgtggagg agctcctgat cggcggcgag atgatcaagg ccggcaccct gaccctggag   2760
gaggtgagga ggaagttcaa caacggcgag atcaacttcg cggccgactg ataa         2814


<210>  123

<211>  2832
<212>  DNA
<213>  artificial sequence

<220>
<223>  polynucleotide encoding TRAC_T01-R TALEN

<400>  123
atgggcgatc ctaaaaagaa acgtaaggtc atcgataagg agaccgccgc tgccaagttc     60
gagagacagc acatggacag catcgatatc gccgatctac gcacgctcgg ctacagccag    120
cagcaacagg agaagatcaa accgaaggtt cgttcgacag tggcgcagca ccacgaggca    180
ctggtcggcc acgggtttac acacgcgcac atcgttgcgt taagccaaca cccggcagcg    240
ttagggaccg tcgctgtcaa gtatcaggac atgatcgcag cgttgccaga ggcgacacac    300
gaagcgatcg ttggcgtcgg caaacagtgg tccggcgcac gcgctctgga ggccttgctc    360
acggtggcgg gagagttgag aggtccaccg ttacagttgg acacaggcca acttctcaag    420
attgcaaaac gtggcggcgt gaccgcagtg gaggcagtgc atgcatggcg caatgcactg    480
acgggtgccc cgctcaactt gaccccggag caggtggtgg ccatcgccag ccacgatggc    540
ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc    600
ttgacccccc agcaggtggt ggccatcgcc agcaatggcg gtggcaagca ggcgctggag    660
acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg    720
gtggccatcg ccagccacga tggcggcaag caggcgctgg agacggtcca gcggctgttg    780
ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagcaat    840
attggtggca agcaggcgct ggagacggtg caggcgctgt tgccggtgct gtgccaggcc    900
cacggcttga ccccccagca ggtggtggcc atcgccagca ataatggtgg caagcaggcg    960
ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccggag   1020
caggtggtgg ccatcgccag ccacgatggc ggcaagcagg cgctggagac ggtccagcgg   1080
ctgttgccgg tgctgtgcca ggcccacggc ttgacccccc agcaggtggt ggccatcgcc   1140
agcaatggcg gtggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc   1200
caggcccacg gcttgacccc ccagcaggtg gtggccatcg ccagcaataa tggtggcaag   1260
caggcgctgg agacggtcca gcggctgttg ccggtgctgt gccaggccca cggcttgacc   1320
ccccagcagg tggtggccat cgccagcaat aatggtggca agcaggcgct ggagacggtc   1380
cagcggctgt tgccggtgct gtgccaggcc cacggcttga ccccccagca ggtggtggcc   1440
atcgccagca atggcggtgg caagcaggcg ctggagacgg tccagcggct gttgccggtg   1500
ctgtgccagg cccacggctt gaccccggag caggtggtgg ccatcgccag caatattggt   1560
ggcaagcagg cgctggagac ggtgcaggcg ctgttgccgg tgctgtgcca ggcccacggc   1620
ttgaccccgg agcaggtggt ggccatcgcc agccacgatg gcggcaagca ggcgctggag   1680
acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg   1740
gtggccatcg ccagcaatat tggtggcaag caggcgctgg agacggtgca ggcgctgttg   1800
ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagccac   1860
gatggcggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc   1920
cacggcttga ccccccagca ggtggtggcc atcgccagca ataatggtgg caagcaggcg   1980
ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gacccctcag   2040
caggtggtgg ccatcgccag caatggcggc ggcaggccgg cgctggagag cattgttgcc   2100
cagttatctc gccctgatcc ggcgttggcc gcgttgacca acgaccacct cgtcgccttg   2160
gcctgcctcg gcgggcgtcc tgcgctggat gcagtgaaaa agggattggg ggatcctatc   2220
agccgttccc agctggtgaa gtccgagctg gaggagaaga aatccgagtt gaggcacaag   2280
ctgaagtacg tgccccacga gtacatcgag ctgatcgaga tcgcccggaa cagcacccag   2340
gaccgtatcc tggagatgaa ggtgatggag ttcttcatga aggtgtacgg ctacaggggc   2400
aagcacctgg gcggctccag gaagcccgac ggcgccatct acaccgtggg ctcccccatc   2460
gactacggcg tgatcgtgga caccaaggcc tactccggcg gctacaacct gcccatcggc   2520
caggccgacg aaatgcagag gtacgtggag gagaaccaga ccaggaacaa gcacatcaac   2580
cccaacgagt ggtggaaggt gtacccctcc agcgtgaccg agttcaagtt cctgttcgtg   2640
tccggccact tcaagggcaa ctacaaggcc cagctgacca ggctgaacca catcaccaac   2700
tgcaacggcg ccgtgctgtc cgtggaggag ctcctgatcg gcggcgagat gatcaaggcc   2760
ggcaccctga ccctggagga ggtgaggagg aagttcaaca acggcgagat caacttcgcg   2820
gccgactgat aa                                                       2832





