SEQUENCE LISTING

<110>  PRONASCI INC.
 
<120>  PEPTIDES DERIVED FROM HUMAN PCSK9 CATALYTIC DOMAIN AND USES THERE OF FOR PROMOTING LDL-R ACTIVITY

<130>  P3234PC00

<150>  61/109,790
<151>  2015-01-30

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser Ile Pro Trp Asn Leu Glu Arg Ile Thr Pro Pro Arg Tyr Arg 
1               5                   10                  15  


<210>  2
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  2

Leu Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln 
1               5                   10                  15  


<210>  3
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  3

Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly Gly 
1               5                   10                  15  

 
<210>  4
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Asp Glu Tyr Gln Pro Pro Asp Gly Gly Ser Leu Val Glu Val 
1               5                   10                  15  


<210>  5
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  5

Pro Pro Asp Gly Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  7

Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp His Arg Glu Ile Glu 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Ile Gln Ser Asp His Arg Glu Ile Glu Gly Arg Val Met Val 
1               5                   10                  15  


<210>  9
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  9

His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn 
1               5                   10                  15  


<210>  10
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  10

Gly Arg Val Met Val Thr Asp Phe Glu Asn Val Pro Glu Glu Asp 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  11

Thr Asp Phe Glu Asn Val Pro Glu Glu Asp Gly Thr Arg Phe His 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  12

Val Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  13

Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp Ser His Gly 
1               5                   10                  15  

<210>  14
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  14

Arg Gln Ala Ser Lys Cys Asp Ser His Gly Thr His Leu Ala Gly 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  15

Cys Asp Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  16

Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly Val Ala 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  17

Val Val Ser Gly Arg Asp Ala Gly Val Ala Lys Gly Ala Ser Met 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  18

Asp Ala Gly Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  19

Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln Gly 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  20

Arg Ser Leu Arg Val Leu Asn Cys Gln Gly Lys Gly Thr Val Ser 
1               5                   10                  15  


<210>  21
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  21

Leu Asn Cys Gln Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly 
1               5                   10                  15  


<210>  22
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  22

Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
1               5                   10                  15  

 

<210>  23
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  23

Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg Lys Ser Gln Leu Val 
1               5                   10                  15  


<210>  24
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  24

Leu Glu Phe Ile Arg Lys Ser Gln Leu Val Gln Pro Val Gly Pro 
1               5                   10                  15  


<210>  25
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  25

Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu 
1               5                   10                  15  


<210>  26
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  26

Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro Leu Ala Gly Gly 
1               5                   10                  15  


<210>  27
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  27

Leu Val Val Leu Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val Leu 
1               5                   10                  15  


<210>  28
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  28

Pro Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln 
1               5                   10                  15  


<210>  29
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  29

Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu Ala Arg Ala 
1               5                   10                  15  


<210>  30
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  30

Asn Ala Ala Cys Gln Arg Leu Ala Arg Ala Gly Val Val Leu Val 
1               5                   10                  15  


<210>  31
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  31

Arg Leu Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn 
1               5                   10                  15  

 

<210>  32
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  32

Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp Asp Ala 
1               5                   10                  15  


<210>  33
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  33

Thr Ala Ala Gly Asn Phe Arg Asp Asp Ala Cys Leu Tyr Ser Pro 
1               5                   10                  15  


<210>  34
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  34

Phe Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu 
1               5                   10                  15  


<210>  35
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  35

Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val Gly 
1               5                   10                  15  


<210>  36
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  36

Ala Ser Ala Pro Glu Val Ile Thr Val Gly Ala Thr Asn Ala Gln 
1               5                   10                  15  


<210>  37
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  37

Val Ile Thr Val Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr 
1               5                   10                  15  


<210>  38
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  38

Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
1               5                   10                  15  


<210>  39
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  39

Asp Gln Pro Val Thr Leu Gly Thr Leu Gly Thr Asn Phe Gly Arg 
1               5                   10                  15  


<210>  40
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  40

Leu Gly Thr Leu Gly Thr Asn Phe Gly Arg Cys Val Asp Leu Phe 
1               5                   10                  15  

 

<210>  41
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  41

Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp 
1               5                   10                  15  


<210>  42
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  42

Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile Ile Gly Ala Ser 
1               5                   10                  15  


<210>  43
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  43

Ala Pro Gly Glu Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser Thr 
1               5                   10                  15  


<210>  44
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  44

Ile Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln 
1               5                   10                  15  


<210>  45
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  45

Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly Thr Ser Gln 
1               5                   10                  15  


<210>  46
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  46

Cys Phe Val Ser Gln Ser Gly Thr Ser Gln Ala Ala Ala His Val 
1               5                   10                  15  


<210>  47
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  47

Ser Gly Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala 
1               5                   10                  15  


<210>  48
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  48

Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu Ser Ala 
1               5                   10                  15  


<210>  49
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  49

Ala Gly Ile Ala Ala Met Met Leu Ser Ala Glu Pro Glu Leu Thr 
1               5                   10                  15  

 

<210>  50
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Met Leu Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg 
1               5                   10                  15  


<210>  51
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  51

Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile His 
1               5                   10                  15  


<210>  52
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  52

Ser Ile Pro Trp Asn Leu Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala 
1               5                   10                  15      


Asp Glu Tyr Gln Pro Pro Asp Gly Gly Ser Leu Val Glu Val Tyr Leu 
            20                  25                  30          


Leu Asp Thr Ser Ile Gln Ser Asp His Arg Glu Ile Glu Gly Arg Val 
        35                  40                  45              


Met Val Thr Asp Phe Glu Asn Val Pro Glu Glu Asp Gly Thr Arg Phe 
    50                  55                  60                  


His Arg Gln Ala Ser Lys Cys Asp Ser His Gly Thr His Leu Ala Gly 
65                  70                  75                  80  


Val Val Ser Gly Arg Asp Ala Gly Val Ala Lys Gly Ala Ser Met Arg 
                85                  90                  95      


Ser Leu Arg Val Leu Asn Cys Gln Gly Lys Gly Thr Val Ser Gly Thr 
            100                 105                 110         


Leu Ile Gly Leu Glu Phe Ile Arg Lys Ser Gln Leu Val Gln Pro Val 
        115                 120                 125             


Gly Pro Leu Val Val Leu Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val 
    130                 135                 140                 


Leu Asn Ala Ala Cys Gln Arg Leu Ala Arg Ala Gly Val Val Leu Val 
145                 150                 155                 160 


Thr Ala Ala Gly Asn Phe Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala 
                165                 170                 175     


Ser Ala Pro Glu Val Ile Thr Val Gly Ala Thr Asn Ala Gln Asp Gln 
            180                 185                 190         


Pro Val Thr Leu Gly Thr Leu Gly Thr Asn Phe Gly Arg Cys Val Asp 
        195                 200                 205             


Leu Phe Ala Pro Gly Glu Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser 
    210                 215                 220                 


Thr Cys Phe Val Ser Gln Ser Gly Thr Ser Gln Ala Ala Ala His Val 
225                 230                 235                 240 


Ala Gly Ile Ala Ala Met Met Leu Ser Ala Glu Pro Glu Leu Thr Leu 
                245                 250                 255     


Ala Glu Leu Arg Gln Arg Leu Ile His Phe Ser Ala 
            260                 265             

 

<210>  53
<211>  670
<212>  PRT
<213>  Homo sapiens

<400>  53

Asp Tyr Lys Asp Asp Asp Asp Lys Gln Glu Asp Glu Asp Gly Asp Tyr 
1               5                   10                  15      


Glu Glu Leu Val Leu Ala Leu Arg Ser Glu Glu Asp Gly Leu Ala Glu 
            20                  25                  30          


Ala Pro Glu His Gly Thr Thr Ala Thr Phe His Arg Cys Ala Lys Asp 
        35                  40                  45              


Pro Trp Arg Leu Pro Gly Thr Tyr Val Val Val Leu Lys Glu Glu Thr 
    50                  55                  60                  


His Leu Ser Gln Ser Glu Arg Thr Ala Arg Arg Leu Gln Ala Gln Ala 
65                  70                  75                  80  


Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu His Val Phe His Gly Leu 
                85                  90                  95      


Leu Pro Gly Phe Leu Val Lys Met Ser Gly Asp Leu Leu Glu Leu Ala 
            100                 105                 110         


Leu Lys Leu Pro His Val Asp Tyr Ile Glu Glu Asp Ser Ser Val Phe 
        115                 120                 125             


Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg Ile Thr Pro Pro Arg Tyr 
    130                 135                 140                 


Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly Gly Ser Leu Val Glu Val 
145                 150                 155                 160 


Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp His Arg Glu Ile Glu Gly 
                165                 170                 175     


Arg Val Met Val Thr Asp Phe Glu Asn Val Pro Glu Glu Asp Gly Thr 
            180                 185                 190         


Arg Phe His Arg Gln Ala Ser Lys Cys Asp Ser His Gly Thr His Leu 
        195                 200                 205             


Ala Gly Val Val Ser Gly Arg Asp Ala Gly Val Ala Lys Gly Ala Ser 
    210                 215                 220                 


Met Arg Ser Leu Arg Val Leu Asn Cys Gln Gly Lys Gly Thr Val Ser 
225                 230                 235                 240 


Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg Lys Ser Gln Leu Val Gln 
                245                 250                 255     


Pro Val Gly Pro Leu Val Val Leu Leu Pro Leu Ala Gly Gly Tyr Ser 
            260                 265                 270         


Arg Val Leu Asn Ala Ala Cys Gln Arg Leu Ala Arg Ala Gly Val Val 
        275                 280                 285             


Leu Val Thr Ala Ala Gly Asn Phe Arg Asp Asp Ala Cys Leu Tyr Ser 
    290                 295                 300                 


Pro Ala Ser Ala Pro Glu Val Ile Thr Val Gly Ala Thr Asn Ala Gln 
305                 310                 315                 320 


Asp Gln Pro Val Thr Leu Gly Thr Leu Gly Thr Asn Phe Gly Arg Cys 
                325                 330                 335     


Val Asp Leu Phe Ala Pro Gly Glu Asp Ile Ile Gly Ala Ser Ser Asp 
            340                 345                 350         


Cys Ser Thr Cys Phe Val Ser Gln Ser Gly Thr Ser Gln Ala Ala Ala 
        355                 360                 365             


His Val Ala Gly Ile Ala Ala Met Met Leu Ser Ala Glu Pro Glu Leu 
    370                 375                 380                 


Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile His Phe Ser Ala Lys Asp 
385                 390                 395                 400 


Val Ile Asn Glu Ala Trp Phe Pro Glu Asp Gln Arg Val Leu Thr Pro 
                405                 410                 415     


Asn Leu Val Ala Ala Leu Pro Pro Ser Thr His Gly Ala Gly Trp Gln 
            420                 425                 430         


Leu Phe Cys Arg Thr Val Trp Ser Ala His Ser Gly Pro Thr Arg Met 
        435                 440                 445             


Ala Thr Ala Val Ala Arg Cys Ala Pro Asp Glu Glu Leu Leu Ser Cys 
    450                 455                 460                 


Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg Gly Glu Arg Met Glu Ala 
465                 470                 475                 480 


Gln Gly Gly Lys Leu Val Cys Arg Ala His Asn Ala Phe Gly Gly Glu 
                485                 490                 495     


Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu Leu Pro Gln Ala Asn Cys 
            500                 505                 510         


Ser Val His Thr Ala Pro Pro Ala Glu Ala Ser Met Gly Thr Arg Val 
        515                 520                 525             


His Cys His Gln Gln Gly His Val Leu Thr Gly Cys Ser Ser His Trp 
    530                 535                 540                 


Glu Val Glu Asp Leu Gly Thr His Lys Pro Pro Val Leu Arg Pro Arg 
545                 550                 555                 560 


Gly Gln Pro Asn Gln Cys Val Gly His Arg Glu Ala Ser Ile His Ala 
                565                 570                 575     


Ser Cys Cys His Ala Pro Gly Leu Glu Cys Lys Val Lys Glu His Gly 
            580                 585                 590         


Ile Pro Ala Pro Gln Glu Gln Val Thr Val Ala Cys Glu Glu Gly Trp 
        595                 600                 605             


Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly Thr Ser His Val Leu Gly 
    610                 615                 620                 


Ala Tyr Ala Val Asp Asn Thr Cys Val Val Arg Ser Arg Asp Val Ser 
625                 630                 635                 640 


Thr Thr Gly Ser Thr Ser Glu Gly Ala Val Thr Ala Val Ala Ile Cys 
                645                 650                 655     


Cys Arg Ser Arg His Leu Ala Gln Ala Ser Gln Glu Leu Gln 
            660                 665                 670 


<210>  54
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  54

Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val Gly Ala 
1               5                   10                  15      


Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly Thr Asn 
            20                  25                  30          


Phe Gly Arg 
        35  


<210>  55
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  55

Ile Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser 
1               5                   10                  15      


Gly Thr Ser Gln Ala Ala Ala His Val 
            20                  25  

 

<210>  56
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  56

Gly Glu Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val 
1               5                   10                  15      


Ser Gln Ser Gly 
            20  


<210>  57
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  57

Gly Glu Asp Ile Ile Gly Ala Ser Ser Tyr Cys Ser Thr Cys Phe Val 
1               5                   10                  15      


Ser Gln Ser Gly 
            20  
