                         SEQUENCE LISTING

<110>  Cornell University
       THE CHILDREN'S HOSPITAL OF PHILADELPHIA
 
<120>  VIRAL VECTORS FOR PROPHYLAXIS AND THERAPY OF HEMOGLOBINOPATHIES

<130>  018617.00651

<150>  62/105,829
<151>  2015-10-21

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  2875
<212>  DNA
<213>  artificial sequence

<220>
<223>  ZF-Ldb1 vector as DNA equivalent of RNA lentivirus

<400>  1
cgcgttcgaa ggggcaacca ggggtccgcg cgccgaggcc tggggagcgg ggcctcctgg       60

ggttggggga ggaggtgctc ttgtaatctg cggtggtccc caggcgggcg ccacccctcc      120

gcccgcccgt gccgggagcg cccggcccga cagcaagcgc ctctggggcc gataaggccc      180

tcgggggcct ggcccgcacg tcacaggccc cgcagaggct gcggtgagtc cgccagcccc      240

agctgctcct cctcaagccc ccaaggccct tcggcggcaa ttcccaccgg tcgccaccat      300

ggcccaggcg gccttggagc ccggagagaa accctacaaa tgcccggagt gtggaaagtc      360

cttcagcgac tgtagggacc tggcacgcca ccagcgaacc cacacaggcg agaagcccta      420

taaatgtcca gagtgtggaa agagcttctc tagaaacgat gcactgactg agcaccaacg      480

cacccatacc ggggaaaaac cttataaatg tcctgagtgt ggtaaaagtt tttctcaatt      540

ggctcatctc cgcgctcacc aacgcacgca tactggtgag aagccctata agtgccccga      600

atgcggcaag agtttttctc aaagcgggga ccttagaaga caccaaagaa cccataccgg      660

cgaaaaacct tacaagtgtc ccgagtgcgg aaaatctttt tcacgcaaag acaatttgaa      720

gaaccaccag cggacacaca ccggtgaaaa gccttacaaa tgtcccgaat gtggcaagtc      780

attctcagac cccggagccc tggtgcgcca tcagcgcact cacactggca agaagactag      840

cggccaggcc ggccaggcta gcccgaaaaa gaaacgcaaa gttgggcgcg ccctggatcg      900

ggatgtgggc ccaactccca tgtacccacc tacatacctg gagcctggga tcgggaggca      960

cacaccatat ggtaaccaaa ccgactatag aatatttgag cttaacaaac ggctacagaa     1020

ctggacagag gagtgtgaca atctctggtg ggatgctttc acaactgagt tctttgaaga     1080

tgacgccatg ctgaccatca ctttctgctt ggaggatgga ccaaagagat ataccattgg     1140

ccggaccctg ataccacgct acttccgaag catttttgag gggggtgcca cagagctgta     1200

ctacgtgctc aagcacccca aggaggcatt ccacagcaac ttcgtgtccc tcgactgtga     1260

ccagggcagc atggtgaccc agcacggcaa acccatgttt acccaggtgt gtgtggaagg     1320

ccggttgtac ctggagttca tgtttgacga catgatgcgg ataaagacgt ggcacttcag     1380

catccggcaa cacagagagc tcatccccag aagtatcctg gccatgcacg cccaggaccc     1440

ccagatgctg gatcagctgt ccaaaaacat tacccggtgt gggctgtcct taattaacta     1500

cccgtacgac gttccggact acgcttcttg aatcggtagg aattaattct gcagcggccg     1560

cggatccgcc cctctccctc ccccccccct aacgttactg gccgaagccg cttggaataa     1620

ggccggtgtg cgtttgtcta tatgttattt tccaccatat tgccgtcttt tggcaatgtg     1680

agggcccgga aacctggccc tgtcttcttg acgagcattc ctaggggtct ttcccctctc     1740

gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag cagttcctct ggaagcttct     1800

tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc ggaacccccc acctggcgac     1860

aggtgcctct gcggccaaaa gccacgtgta taagatacac ctgcaaaggc ggcacaaccc     1920

cagtgccacg ttgtgagttg gatagttgtg gaaagagtca aatggctctc ctcaagcgta     1980

ttcaacaagg ggctgaagga tgcccagaag gtaccccatt gtatgggatc tgatctgggg     2040

cctcggtgca catgctttac atgtgtttag tcgaggttaa aaaaacgtct aggccccccg     2100

aaccacgggg acgtggtttt cctttgaaaa acacgatgat aatatggcca caaccatggt     2160

gagcaagggc gaggagctgt tcaccggggt ggtgcccatc ctggtcgagc tggacggcga     2220

cgtaaacggc cacaagttca gcgtgtccgg cgagggcgag ggcgatgcca cctacggcaa     2280

gctgaccctg aagttcatct gcaccaccgg caagctgccc gtgccctggc ccaccctcgt     2340

gaccaccctg acctacggcg tgcagtgctt cagccgctac cccgaccaca tgaagcagca     2400

cgacttcttc aagtccgcca tgcccgaagg ctacgtccag gagcgcacca tcttcttcaa     2460

ggacgacggc aactacaaga cccgcgccga ggtgaagttc gagggcgaca ccctggtgaa     2520

ccgcatcgag ctgaagggca tcgacttcaa ggaggacggc aacatcctgg ggcacaagct     2580

ggagtacaac tacaacagcc acaacgtcta tatcatggcc gacaagcaga agaacggcat     2640

caaggtgaac ttcaagatcc gccacaacat cgaggacggc agcgtgcagc tcgccgacca     2700

ctaccagcag aacaccccca tcggcgacgg ccccgtgctg ctgcccgaca accactacct     2760

gagcacccag tccgccctga gcaaagaccc caacgagaag cgcgatcaca tggtcctgct     2820

ggagttcgtg accgccgccg ggatcactct cggcatggac gagctgtaca agtaa          2875


<210>  2
<211>  390
<212>  PRT
<213>  artificial sequence

<220>
<223>  ZF-LDB1 fusion

<400>  2

Met Ala Gln Ala Ala Leu Glu Pro Gly Glu Lys Pro Tyr Lys Cys Pro 
1               5                   10                  15      


Glu Cys Gly Lys Ser Phe Ser Asp Cys Arg Asp Leu Ala Arg His Gln 
            20                  25                  30          


Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys 
        35                  40                  45              


Ser Phe Ser Arg Asn Asp Ala Leu Thr Glu His Gln Arg Thr His Thr 
    50                  55                  60                  


Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Gln 
65                  70                  75                  80  


Leu Ala His Leu Arg Ala His Gln Arg Thr His Thr Gly Glu Lys Pro 
                85                  90                  95      


Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Gln Ser Gly Asp Leu 
            100                 105                 110         


Arg Arg His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro 
        115                 120                 125             


Glu Cys Gly Lys Ser Phe Ser Arg Lys Asp Asn Leu Ser Phe Ser Asp 
    130                 135                 140                 


Pro Gly Ala Leu Val Arg His Gln Arg Thr His Thr Gly Lys Lys Thr 
145                 150                 155                 160 


Ser Gly Gln Ala Gly Gln Ala Ser Pro Lys Lys Lys Arg Lys Val Gly 
                165                 170                 175     


Arg Ala Leu Asp Arg Asp Val Gly Pro Thr Pro Met Tyr Pro Pro Thr 
            180                 185                 190         


Tyr Leu Glu Pro Gly Ile Gly Arg His Thr Pro Tyr Gly Asn Gln Thr 
        195                 200                 205             


Asp Tyr Arg Ile Phe Glu Leu Asn Lys Arg Leu Gln Asn Trp Thr Glu 
    210                 215                 220                 


Glu Cys Asp Asn Leu Trp Trp Asp Ala Phe Thr Thr Glu Phe Phe Glu 
225                 230                 235                 240 


Asp Asp Ala Met Leu Thr Ile Thr Phe Cys Leu Glu Asp Gly Pro Lys 
                245                 250                 255     


Arg Tyr Thr Ile Gly Arg Thr Leu Ile Pro Arg Tyr Phe Arg Ser Ile 
            260                 265                 270         


Phe Glu Gly Gly Ala Thr Glu Leu Tyr Tyr Val Leu Lys His Pro Lys 
        275                 280                 285             


Glu Ala Phe His Ser Asn Phe Val Ser Leu Asp Cys Asp Gln Gly Ser 
    290                 295                 300                 


Met Val Thr Gln His Gly Lys Pro Met Phe Thr Gln Val Cys Val Glu 
305                 310                 315                 320 


Gly Arg Leu Tyr Leu Glu Phe Met Phe Asp Asp Met Met Arg Ile Lys 
                325                 330                 335     


Thr Trp His Phe Ser Ile Arg Gln His Arg Glu Leu Ile Pro Arg Ser 
            340                 345                 350         


Ile Leu Ala Met His Ala Gln Asp Pro Gln Met Leu Asp Gln Leu Ser 
        355                 360                 365             


Lys Asn Ile Thr Arg Cys Gly Leu Ser Leu Ile Asn Tyr Pro Tyr Asp 
    370                 375                 380                 


Val Pro Asp Tyr Ala Ser 
385                 390 


<210>  3
<211>  13550
<212>  DNA
<213>  artificial sequence

<220>
<223>  ALS10 as DNA equilvalent of RNA lentiviral vector

<400>  3
ctgtcagacc aagtttactc atatatactt tagattgatt taaaacttca tttttaattt       60

aaaaggatct aggtgaagat cctttttgat aatctcatga ccaaaatccc ttaacgtgag      120

ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc ttgagatcct      180

ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt      240

tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg      300

cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt caagaactct      360

gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc      420

gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg      480

tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa      540

ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg      600

gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg      660

ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga      720

tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt      780

ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc gttatcccct      840

gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg ccgcagccga      900

acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcccaat acgcaaaccg      960

cctctccccg cgcgttggcc gattcattaa tgcagctggc acgacaggtt tcccgactgg     1020

aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc tcactcatta ggcaccccag     1080

gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa ttgtgagcgg ataacaattt     1140

cacacaggaa acagctatga ccatgattac gccaagcgcg caattaaccc tcactaaagg     1200

gaacaaaagc tggagctgca agcttggcca ttgcatacgt tgtatccata tcataatatg     1260

tacatttata ttggctcatg tccaacatta ccgccatgtt gacattgatt attgactagt     1320

tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt     1380

acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg     1440

tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg     1500

gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt     1560

acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg     1620

accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg     1680

gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt     1740

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac     1800

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg     1860

tgggaggtct atataagcag agctcgttta gtgaaccggg gtctctctgg ttagaccaga     1920

tctgagcctg ggagctctct ggctaactag ggaacccact gcttaagcct caataaagct     1980

tgccttgagt gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt aactagagat     2040

ccctcagacc cttttagtca gtgtggaaaa tctctagcag tggcgcccga acagggacct     2100

gaaagcgaaa gggaaaccag agctctctcg acgcaggact cggcttgctg aagcgcgcac     2160

ggcaagaggc gaggggcggc gactggtgag tacgccaaaa attttgacta gcggaggcta     2220

gaaggagaga gatgggtgcg agagcgtcag tattaagcgg gggagaatta gatcgcgatg     2280

ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat aaattaaaac atatagtatg     2340

ggcaagcagg gagctagaac gattcgcagt taatcctggc ctgttagaaa catcagaagg     2400

ctgtagacaa atactgggac agctacaacc atcccttcag acaggatcag aagaacttag     2460

atcattatat aatacagtag caaccctcta ttgtgtgcat caaaggatag agataaaaga     2520

caccaaggaa gctttagaca agatagagga agagcaaaac aaaagtaaga ccaccgcaca     2580

gcaagcggcc gctgatcttc agacctggag gaggagatat gagggacaat tggagaagtg     2640

aattatataa atataaagta gtaaaaattg aaccattagg agtagcaccc accaaggcaa     2700

agagaagagt ggtgcagaga gaaaaaagag cagtgggaat aggagctttg ttccttgggt     2760

tcttgggagc agcaggaagc actatgggcg cagcctcaat gacgctgacg gtacaggcca     2820

gacaattatt gtctggtata gtgcagcagc agaacaattt gctgagggct attgaggcgc     2880

aacagcatct gttgcaactc acagtctggg gcatcaagca gctccaggca agaatcctgg     2940

ctgtggaaag atacctaaag gatcaacagc tcctggggat ttggggttgc tctggaaaac     3000

tcatttgcac cactgctgtg ccttggaatg ctagttggag taataaatct ctggaacaga     3060

tttggaatca cacgacctgg atggagtggg acagagaaat taacaattac acaagcttaa     3120

tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa gaatgaacaa gaattattgg     3180

aattagataa atgggcaagt ttgtggaatt ggtttaacat aacaaattgg ctgtggtata     3240

taaaattatt cataatgata gtaggaggct tggtaggttt aagaatagtt tttgctgtac     3300

tttctatagt gaatagagtt aggcagggat attcaccatt atcgtttcag acccacctcc     3360

caaccccgag gggacccgac aggcccgaag gaatagaaga agaaggtgga gagagagaca     3420

gagacagatc cattcgatta gtgaacggat ctcgacggta tcggttaact tttaaaagaa     3480

aaggggggat tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca     3540

tacaaactaa agaattacaa aaacaaatta caaaaattca aaattttatc gataagcttg     3600

ggagttccgc gtgttggggg tggaccatcc tctaggtatt gaataagaaa aatgaagtta     3660

aggtggttga tggtaacact atgctaataa ctgcagagcc agaagcacca taagggacat     3720

gataagggag ccagcagacc tctgatctct tcctgaatgc taatcttaaa catcctgagg     3780

aagaatggga cttccatttg gggtgggcct atgatagggt aataagacag tagtgaatat     3840

caagctacaa aaagccccct ttcaaattct tctcagtcct aacttttcat actaagccca     3900

gtccttccaa agcagactgt gaaagagtga tagttccggg agactagcac tgcagattcc     3960

gggtcactgt gagtggggga ggcagggaag aagggctcac aggacagtca aaccatgccc     4020

cctgtttttc cttcttcaag tagacctcta taagacaaca gagacaacta aggctgagtg     4080

gccaggcgag gagaaaccat ctcgccgtaa aacatggaag gaacacttca ggggaaaggt     4140

ggtatctcta agcaagagaa ctgagtggag tcaaggctga gagatgcagg ataagcaaat     4200

gggtagtgaa aagacattca tgaggacagc taaaacaata agtaatgtaa aatacagcat     4260

agcaaaactt taacctccaa atcaagcctc tacttgaatc cttttctgag ggatgaataa     4320

ggcataggca tcaggggctg ttgccaatgt gcattagctg tttgcagcct caccttcttt     4380

catggagttt aagatatagt gtattttccc aaggtttgaa ctagctcttc atttctttat     4440

gttttaaatg cactgacctc ccacattccc tttttagtaa aatattcaga aataatttaa     4500

atacatcatt gcaatgaaaa taaatgtttt ttattaggca gaatccagat gctcaaggcc     4560

cttcataata tcccccagtt tagtagttgg acttagggaa caaaggaacc tttaatagaa     4620

attggacagc aagaaagcga gcttagtgat acttgtgggc cagggcatta gccacaccag     4680

ccaccacttt ctgataggca gcctgcactg gtggggtgaa ttctttgcca aagtgatggg     4740

ccagcacaca gaccagcacg ttgcccagga gctgtgggag gaagataaga ggtatgaaca     4800

tgattagcaa aagggcctag cttggactca gaataatcca gccttatccc aaccataaaa     4860

taaaagcaga atggtagctg gattgtagct gctattagca atatgaaacc tcttacatca     4920

gttacaattt atatgcagaa atatttatat gcagaaatat tgctattgcc ttaacccaga     4980

aattatcact gttattcttt agaatggtgc aaagaggcat gatacattgt atcattattg     5040

ccctgaaaga aagagattag ggaaagtatt agaaataaga taaacaaaaa agtatattaa     5100

aagaagaaag cattttttaa aattacaaat gcaaaattac cctgatttgg tcaatatgtg     5160

tacacatatt aaaacattac actttaaccc ataaatatgt ataatgatta tgtatcaatt     5220

aaaaataaaa gaaaataaag tagggagatt atgaatatgc aaataagcac acatatattc     5280

caaatagtaa tgtactaggc agactgtgta aagttttttt ttaagttact taatgtatct     5340

cagagatatt tccttttgtt atacacaatg ttaaggcatt aagtataata gtaaaaattg     5400

cggagaagaa aaaaaaagaa agcaagaatt aaacaaaaga aaacaattgt tatgaacagc     5460

aaataaaaga aactaaaacg atcctgagac ttccacactg atgcaatcat tcgtctgttt     5520

cccattctaa actgtaccct gttacttctc cccttcctat gacatgaact taaccataga     5580

aaagaagggg aaagaaaaca tcaagggtcc catagactca ccctgaagtt ctcaggatcc     5640

acgtgcagct tgtcacagtg cagctcactc agtgtggcaa aggtgccctt gaggttgtcc     5700

aggtgagcca ggccatcact aaaggcaccg agcactttct tgccatgagc cttcacctta     5760

gggttgccca taacagcatc aggagtggac agatccccaa aggactcaaa gaacctctgg     5820

gtccaagggt agaccaccag cagcctaagg gtgggaaaat agaccaatag gcagagagag     5880

tcagtgccta tcagaaaccc aagagtcttc tctgtctcca catgcccagt ttctattggt     5940

ctccttaaac ctgtcttgta accttgatac caacctgccc agggcctcac caccaacttc     6000

atccacgttc accttgcccc acagggcagt aacggcagac ttctcctcag gagtcaggtg     6060

caccatggtg tctgtttgag gttgctagtg aacacagttg tgtcagaagc aaatgtaagc     6120

aatagatggc tctgccctga cttttatgcc cagccctggc tcctgccctc cctgctcctg     6180

ggagtagatt ggccaaccct agggtgtggc tccacagggt gaggtctaag tgatgacagc     6240

cgtacctgtc cttggctctt ctggcactgg cttaggagtt ggacttcaaa ccctcagccc     6300

tccctctaag atatatctct tggccccata ccatcagtac aaattgctac taaaaacatc     6360

ctcctttgca agtgtattta cgtaatattt ggaatcacag cttggtaagc atattgaaga     6420

tcgttttccc aattttctta ttacacaaat aagaaattga tgcactaaaa gtggaagagt     6480

tttgtctacc ataattcagc tttgggatat gtagatggat ctcttcctgc gtctccagaa     6540

tatgcaaaat acttacagga cagaatggat gaaaactcta cctcagttct aagcatatct     6600

tctccttatt tggattaaaa ccttctggta agaaaagaaa aaaaatatat atatatatgt     6660

gtatatatac acacatacat atacatatat atgcattcat ttgttgttgt ttttcttaat     6720

ttgctcatgg tatatgtgta tatatatata tatatattca ggaaataata tattctagaa     6780

tatgtcacat tctgtctcag gcatccattt tctttatgat gccgtttgag gtggagtttt     6840

agtcaggtgg tcagcttctc cttttttttg ccatctgccc tgtaagcatc ctgctgggga     6900

cccagatagg agtcatcact ctaggctgag aacatctggg cacacaccct aagcctcagc     6960

atgactcatc atgactcagc attgctgtgc ttgagccaga aggtttgctt agaaggttac     7020

acagaaccag aaggcggggg tggggcactg accccgacag gggcctggcc agaactgctc     7080

atgcttggac tatgggaggt cactaatgga gacacacaga aatgtaacag gaactaagga     7140

aaaactgaag cttatttaat cagagatgag atgctggaag ggatagaggg agctgagctt     7200

gtaaaaagta tagtaatcat tcagcaaatg gttttgaagc acctgctgga tgctaaacac     7260

tattttcagt gcttgaatca taaataagaa taaaacatgt atcttattcc ccacaagagt     7320

ccaagtaaaa aataacagtt aattataatg tgctctgtcc cccaggctgg agtgcagtgg     7380

cacgatctca gctcactgca acctccgcct cccgggttca agcaattctc ctgcctcagc     7440

caccctaata gctgggatta caggtgcaca ccaccatgcc aggctaattt ttgtactttt     7500

tgtagaggca gggtatcacc atgttgtcca agatggtctt gaactcctga gctccaagca     7560

gtccacccac ctcagcctcc caaagtgcta tctgcggccg cctatctgta ccactagtct     7620

cgagaagctt tcattaaaaa aagtctaacc agctgcattc gactttgact gcagcagctg     7680

gttagaaggt tctactggag gagggtccca gcccattgct aaattaacat caggctctga     7740

gactggcagt atatctctaa cagtggttga tgctatcttc tggaacttgc ctgctacatt     7800

gagaccactg acccatacat aggaagccca tagctctgtc ctgaactgtt aggccactgg     7860

tccagagagt gtgcatctcc tttgatcctc ataataaccc tatgagatag acacaattat     7920

tactcttact ttatagatga tgatcctgaa aacataggag tcaaggcact tgcccctagc     7980

tgggggtata ggggagcagt cccatgtagt agtagaatga aaaatgctgc tatgctgtgc     8040

ctcccccacc tttcccatgt ctgccctcta ctcatggtct atctctcctg gctcctggga     8100

gtcatggact ccacccagca ccaccaacct gacctaacca cctatctgag cctgccagcc     8160

tataacccat ctgggccctg atagctggtg gccagccctg accccacccc accctccctg     8220

gaacctctga tagacacatc tggcacacca gctcgcaaag tcaccgtgag ggtcttgtgt     8280

ttgctgagtc aaaattcctt gaaatccaag tccttagaga ctcctgctcc caaatttaca     8340

gtcatagact tcttcatggc tgtctccttt atccacagaa tgattccttt gcttcattgc     8400

cccatccatc tgatcctcct catcagtgca gcacagggcc catgagcagt agctgcagag     8460

tctcacatag gtctggcact gcctctgaca tgtccgacct taggcaaatg cttgactctt     8520

ctgagctcag tcttgtcatg gcaaaataaa gataataata gtgttttttt atggagttag     8580

cgtgaggatg gaaaacaata gcaaaattga ttagactata aaaggtctca acaaatagta     8640

gtagatttta tcatccatta atccttccct ctcctctctt actcatccca tcacgtatgc     8700

ctcttaattt tcccttacct ataataagag ttattcctct tattatattc ttcttatagt     8760

gattctggat attaaagtgg gaatgagggg caggccacta acgaagaaga tgtttctcaa     8820

agaagccatt ctccccacat agatcatctc agcagggttc aggaagataa aggaggatca     8880

aggtcgaagg taggaactaa ggaagaacac tgggcaagtg gatcctgagc cccttttcct     8940

ctaactgaaa gaaggaaaaa aaaaatggaa cccaaaatat tctacatagt ttccatgtca     9000

cagccagggc tgggcagtct cctgttattt cttttaaaat aaatatatca tttaaatgca     9060

taaataagca aaccctgctc gggaatggga gggagagtct ctggagtcca ccccttctcg     9120

gccctggctc tgcagatagt gctatcaaag ccctgacaga gccctgccca ttgctgggcc     9180

ttggagtgag tcagcctagt agagaggcag ggcaagccat ctcatagctg ctgagtggga     9240

gagagaaaag ggctcattgt ctataaactc aggtcatggc tattcttatt ctcacactaa     9300

gaaaaagaat gagatgtcta catataccct gcgtcccctc ttgtgtactg gggcccccaa     9360

gagctctcta aaagtgatgg caaagtcatt gcgctagatg ccatcccatc tattataaac     9420

ctgcatttgt ctccacacac cagtcatgga caataaccct cctcccaggt ccacgtgctt     9480

gtctttgtat aatactcaag taatttcgga aaatgtattc tttcaatctt gttctgttat     9540

tcctgtttca atggcttagt agaaaaagta catacttgtt ttcccataaa ttgacaatag     9600

acaatttcac atcaatgtct atatgggtcg ttgtgtttgc tgtgtttgca aaaactcaca     9660

ataactttat attgttacta ctctaagaaa gttacaacat ggtgaataca agagaaagct     9720

attacaagtc cagaaaataa aagttatcat cttgaggcct cagctttcta ggaataatat     9780

caatattaca aaattaatct aacaattatg aacagcaatg agataatatg tacaaagtac     9840

ccagacctat gtggtagagc atcaaggaag cgcattgcgg agcagttttt tgtttgtttg     9900

tttttgtatt ctgtttcgtg aggcaaggtt tcactctgct gtccaggctg gagtgcagtg     9960

gcaagatcat gtctcactgc agccttgaca ctacacgtgc tttaagacca atgacttaca    10020

aggcagctgt agatcttagc cactttttaa aagaaaaggg gggactggaa gggctaattc    10080

actcccaacg aagacaagat ctgctttttg ctagcgcggc cgctctagac tagtggggcc    10140

cgtgcaattg aagccggctg gcgccaagct tctctgcagg atgtgcgggc caggcccccg    10200

agggccttat cggccccaga ggcgcttgct gtcgggccgg gcgctcccgg cacgggcggg    10260

cggaggggtg gcgcccgcct ggggaccgca gattacaaga gcacctcctc ccccaacccc    10320

aggaggcccc gctccccagg cctcggccgg cgcggacccc tggttgcccc ggatgtacag    10380

gcatgcgtcg acctcgaggg ggggcccggt accgctagca ctgggtctct ctggttagac    10440

cagatctgag cctgggagct ctctggctaa ctagggaacc cactgcttaa gcctcaataa    10500

agcttgcctt gagtgcttca agtagtgtgt gcccgtctgt tgtgtgactc tggtaactag    10560

agatccctca gaccctttta gtcagtgtgg aaaatctcta gcaggtcgac aatcaacctc    10620

tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct ccttttacgc    10680

tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt atggctttca    10740

ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg tggcccgttg    10800

tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact ggttggggca    10860

ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct attgccacgg    10920

cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg ttgggcactg    10980

acaattccgt ggtgttgtcg gggaagctga cgtcctttcc atggctgctc gcctgtgttg    11040

ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc aatccagcgg    11100

accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt cgccttcgcc    11160

ctcagacgag tcggatctcc ctttgggccg cctccccgcc tggaattcga gctcggtacc    11220

tgatcagcct cgactgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccgtg    11280

ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt    11340

gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggacagc    11400

aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg ctctatggct    11460

tctgaggaaa gaaccagctg gggctcgaga tccactagtt ctagcctcga ggctagagcg    11520

gccgccaccg cggtagtagt tcatgtcatc ttattattca gtatttataa cttgcaaaga    11580

aatgaatatc agagagtgag aggaacttgt ttattgcagc ttataatggt tacaaataaa    11640

gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt    11700

tgtccaaact catcaatgta tcttatcatg tctggctcta gctatcccgc ccctaactcc    11760

gcccagttcc gcccattctc cgccccatgg ctgactaatt ttttttattt atgcagaggc    11820

cgaggccgcc tcggcctctg agctattcca gaagtagtga ggaggctttt ttggaggcct    11880

aggcttttgc gtcgagacgt acccaattcg ccctatagtg agtcgtatta cgcgcgctca    11940

ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg gcgttaccca acttaatcgc    12000

cttgcagcac atcccccttt cgccagctgg cgtaatagcg aagaggcccg caccgatcgc    12060

ccttcccaac agttgcgcag cctgaatggc gaatggcgcg acgcgccctg tagcggcgca    12120

ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta    12180

gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg ctttccccgt    12240

caagctctaa atcgggggct ccctttaggg ttccgattta gtgctttacg gcacctcgac    12300

cccaaaaaac ttgattaggg tgatggttca cgtagtgggc catcgccctg atagacggtt    12360

tttcgccctt tgacgttgga gtccacgttc tttaatagtg gactcttgtt ccaaactgga    12420

acaacactca accctatctc ggtctattct tttgatttat aagggatttt gccgatttcg    12480

gcctattggt taaaaaatga gctgatttaa caaaaattta acgcgaattt taacaaaata    12540

ttaacgttta caatttccca ggtggcactt ttcggggaaa tgtgcgcgga acccctattt    12600

gtttattttt ctaaatacat tcaaatatgt atccgctcat gagacaataa ccctgataaa    12660

tgcttcaata atattgaaaa aggaagagta tgagtattca acatttccgt gtcgccctta    12720

ttcccttttt tgcggcattt tgccttcctg tttttgctca cccagaaacg ctggtgaaag    12780

taaaagatgc tgaagatcag ttgggtgcac gagtgggtta catcgaactg gatctcaaca    12840

gcggtaagat ccttgagagt tttcgccccg aagaacgttt tccaatgatg agcactttta    12900

aagttctgct atgtggcgcg gtattatccc gtattgacgc cgggcaagag caactcggtc    12960

gccgcataca ctattctcag aatgacttgg ttgagtactc accagtcaca gaaaagcatc    13020

ttacggatgg catgacagta agagaattat gcagtgctgc cataaccatg agtgataaca    13080

ctgcggccaa cttacttctg acaacgatcg gaggaccgaa ggagctaacc gcttttttgc    13140

acaacatggg ggatcatgta actcgccttg atcgttggga accggagctg aatgaagcca    13200

taccaaacga cgagcgtgac accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac    13260

tattaactgg cgaactactt actctagctt cccggcaaca attaatagac tggatggagg    13320

cggataaagt tgcaggacca cttctgcgct cggcccttcc ggctggctgg tttattgctg    13380

ataaatctgg agccggtgag cgtgggtctc gcggtatcat tgcagcactg gggccagatg    13440

gtaagccctc ccgtatcgta gttatctaca cgacggggag tcaggcaact atggatgaac    13500

gaaatagaca gatcgctgag ataggtgcct cactgattaa gcattggtaa               13550


<210>  4
<211>  13550
<212>  DNA
<213>  human

<400>  4
ctgtcagacc aagtttactc atatatactt tagattgatt taaaacttca tttttaattt       60

aaaaggatct aggtgaagat cctttttgat aatctcatga ccaaaatccc ttaacgtgag      120

ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc ttgagatcct      180

ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt      240

tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg      300

cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt caagaactct      360

gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc      420

gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg      480

tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa      540

ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg      600

gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg      660

ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga      720

tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt      780

ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc gttatcccct      840

gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg ccgcagccga      900

acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcccaat acgcaaaccg      960

cctctccccg cgcgttggcc gattcattaa tgcagctggc acgacaggtt tcccgactgg     1020

aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc tcactcatta ggcaccccag     1080

gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa ttgtgagcgg ataacaattt     1140

cacacaggaa acagctatga ccatgattac gccaagcgcg caattaaccc tcactaaagg     1200

gaacaaaagc tggagctgca agcttggcca ttgcatacgt tgtatccata tcataatatg     1260

tacatttata ttggctcatg tccaacatta ccgccatgtt gacattgatt attgactagt     1320

tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt     1380

acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg     1440

tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg     1500

gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt     1560

acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg     1620

accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg     1680

gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt     1740

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac     1800

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg     1860

tgggaggtct atataagcag agctcgttta gtgaaccggg gtctctctgg ttagaccaga     1920

tctgagcctg ggagctctct ggctaactag ggaacccact gcttaagcct caataaagct     1980

tgccttgagt gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt aactagagat     2040

ccctcagacc cttttagtca gtgtggaaaa tctctagcag tggcgcccga acagggacct     2100

gaaagcgaaa gggaaaccag agctctctcg acgcaggact cggcttgctg aagcgcgcac     2160

ggcaagaggc gaggggcggc gactggtgag tacgccaaaa attttgacta gcggaggcta     2220

gaaggagaga gatgggtgcg agagcgtcag tattaagcgg gggagaatta gatcgcgatg     2280

ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat aaattaaaac atatagtatg     2340

ggcaagcagg gagctagaac gattcgcagt taatcctggc ctgttagaaa catcagaagg     2400

ctgtagacaa atactgggac agctacaacc atcccttcag acaggatcag aagaacttag     2460

atcattatat aatacagtag caaccctcta ttgtgtgcat caaaggatag agataaaaga     2520

caccaaggaa gctttagaca agatagagga agagcaaaac aaaagtaaga ccaccgcaca     2580

gcaagcggcc gctgatcttc agacctggag gaggagatat gagggacaat tggagaagtg     2640

aattatataa atataaagta gtaaaaattg aaccattagg agtagcaccc accaaggcaa     2700

agagaagagt ggtgcagaga gaaaaaagag cagtgggaat aggagctttg ttccttgggt     2760

tcttgggagc agcaggaagc actatgggcg cagcctcaat gacgctgacg gtacaggcca     2820

gacaattatt gtctggtata gtgcagcagc agaacaattt gctgagggct attgaggcgc     2880

aacagcatct gttgcaactc acagtctggg gcatcaagca gctccaggca agaatcctgg     2940

ctgtggaaag atacctaaag gatcaacagc tcctggggat ttggggttgc tctggaaaac     3000

tcatttgcac cactgctgtg ccttggaatg ctagttggag taataaatct ctggaacaga     3060

tttggaatca cacgacctgg atggagtggg acagagaaat taacaattac acaagcttaa     3120

tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa gaatgaacaa gaattattgg     3180

aattagataa atgggcaagt ttgtggaatt ggtttaacat aacaaattgg ctgtggtata     3240

taaaattatt cataatgata gtaggaggct tggtaggttt aagaatagtt tttgctgtac     3300

tttctatagt gaatagagtt aggcagggat attcaccatt atcgtttcag acccacctcc     3360

caaccccgag gggacccgac aggcccgaag gaatagaaga agaaggtgga gagagagaca     3420

gagacagatc cattcgatta gtgaacggat ctcgacggta tcggttaact tttaaaagaa     3480

aaggggggat tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca     3540

tacaaactaa agaattacaa aaacaaatta caaaaattca aaattttatc gataagcttg     3600

ggagttccgc gtgttggggg tggaccatcc tctaggtatt gaataagaaa aatgaagtta     3660

aggtggttga tggtaacact atgctaataa ctgcagagcc agaagcacca taagggacat     3720

gataagggag ccagcagacc tctgatctct tcctgaatgc taatcttaaa catcctgagg     3780

aagaatggga cttccatttg gggtgggcct atgatagggt aataagacag tagtgaatat     3840

caagctacaa aaagccccct ttcaaattct tctcagtcct aacttttcat actaagccca     3900

gtccttccaa agcagactgt gaaagagtga tagttccggg agactagcac tgcagattcc     3960

gggtcactgt gagtggggga ggcagggaag aagggctcac aggacagtca aaccatgccc     4020

cctgtttttc cttcttcaag tagacctcta taagacaaca gagacaacta aggctgagtg     4080

gccaggcgag gagaaaccat ctcgccgtaa aacatggaag gaacacttca ggggaaaggt     4140

ggtatctcta agcaagagaa ctgagtggag tcaaggctga gagatgcagg ataagcaaat     4200

gggtagtgaa aagacattca tgaggacagc taaaacaata agtaatgtaa aatacagcat     4260

agcaaaactt taacctccaa atcaagcctc tacttgaatc cttttctgag ggatgaataa     4320

ggcataggca tcaggggctg ttgccaatgt gcattagctg tttgcagcct caccttcttt     4380

catggagttt aagatatagt gtattttccc aaggtttgaa ctagctcttc atttctttat     4440

gttttaaatg cactgacctc ccacattccc tttttagtaa aatattcaga aataatttaa     4500

atacatcatt gcaatgaaaa taaatgtttt ttattaggca gaatccagat gctcaaggcc     4560

cttcataata tcccccagtt tagtagttgg acttagggaa caaaggaacc tttaatagaa     4620

attggacagc aagaaagcga gcttagtgat acttgtgggc cagggcatta gccacaccag     4680

ccaccacttt ctgataggca gcctgcactg gtggggtgaa ttctttgcca aagtgatggg     4740

ccagcacaca gaccagcacg ttgcccagga gctgtgggag gaagataaga ggtatgaaca     4800

tgattagcaa aagggcctag cttggactca gaataatcca gccttatccc aaccataaaa     4860

taaaagcaga atggtagctg gattgtagct gctattagca atatgaaacc tcttacatca     4920

gttacaattt atatgcagaa atatttatat gcagaaatat tgctattgcc ttaacccaga     4980

aattatcact gttattcttt agaatggtgc aaagaggcat gatacattgt atcattattg     5040

ccctgaaaga aagagattag ggaaagtatt agaaataaga taaacaaaaa agtatattaa     5100

aagaagaaag cattttttaa aattacaaat gcaaaattac cctgatttgg tcaatatgtg     5160

tacacatatt aaaacattac actttaaccc ataaatatgt ataatgatta tgtatcaatt     5220

aaaaataaaa gaaaataaag tagggagatt atgaatatgc aaataagcac acatatattc     5280

caaatagtaa tgtactaggc agactgtgta aagttttttt ttaagttact taatgtatct     5340

cagagatatt tccttttgtt atacacaatg ttaaggcatt aagtataata gtaaaaattg     5400

cggagaagaa aaaaaaagaa agcaagaatt aaacaaaaga aaacaattgt tatgaacagc     5460

aaataaaaga aactaaaacg atcctgagac ttccacactg atgcaatcat tcgtctgttt     5520

cccattctaa actgtaccct gttacttctc cccttcctat gacatgaact taaccataga     5580

aaagaagggg aaagaaaaca tcaagggtcc catagactca ccctgaagtt ctcaggatcc     5640

acgtgcagct tgtcacagtg cagctcactc agtgtggcaa aggtgccctt gaggttgtcc     5700

aggtgagcca ggccatcact aaaggcaccg agcactttct tgccatgagc cttcacctta     5760

gggttgccca taacagcatc aggagtggac agatccccaa aggactcaaa gaacctctgg     5820

gtccaagggt agaccaccag cagcctaagg gtgggaaaat agaccaatag gcagagagag     5880

tcagtgccta tcagaaaccc aagagtcttc tctgtctcca catgcccagt ttctattggt     5940

ctccttaaac ctgtcttgta accttgatac caacctgccc agggcctcac caccaacttc     6000

atccacgttc accttgcccc acagggcagt aacggcagac ttctcctcag gagtcaggtg     6060

caccatggtg tctgtttgag gttgctagtg aacacagttg tgtcagaagc aaatgtaagc     6120

aatagatggc tctgccctga cttttatgcc cagccctggc tcctgccctc cctgctcctg     6180

ggagtagatt ggccaaccct agggtgtggc tccacagggt gaggtctaag tgatgacagc     6240

cgtacctgtc cttggctctt ctggcactgg cttaggagtt ggacttcaaa ccctcagccc     6300

tccctctaag atatatctct tggccccata ccatcagtac aaattgctac taaaaacatc     6360

ctcctttgca agtgtattta cgtaatattt ggaatcacag cttggtaagc atattgaaga     6420

tcgttttccc aattttctta ttacacaaat aagaaattga tgcactaaaa gtggaagagt     6480

tttgtctacc ataattcagc tttgggatat gtagatggat ctcttcctgc gtctccagaa     6540

tatgcaaaat acttacagga cagaatggat gaaaactcta cctcagttct aagcatatct     6600

tctccttatt tggattaaaa ccttctggta agaaaagaaa aaaaatatat atatatatgt     6660

gtatatatac acacatacat atacatatat atgcattcat ttgttgttgt ttttcttaat     6720

ttgctcatgg tatatgtgta tatatatata tatatattca ggaaataata tattctagaa     6780

tatgtcacat tctgtctcag gcatccattt tctttatgat gccgtttgag gtggagtttt     6840

agtcaggtgg tcagcttctc cttttttttg ccatctgccc tgtaagcatc ctgctgggga     6900

cccagatagg agtcatcact ctaggctgag aacatctggg cacacaccct aagcctcagc     6960

atgactcatc atgactcagc attgctgtgc ttgagccaga aggtttgctt agaaggttac     7020

acagaaccag aaggcggggg tggggcactg accccgacag gggcctggcc agaactgctc     7080

atgcttggac tatgggaggt cactaatgga gacacacaga aatgtaacag gaactaagga     7140

aaaactgaag cttatttaat cagagatgag atgctggaag ggatagaggg agctgagctt     7200

gtaaaaagta tagtaatcat tcagcaaatg gttttgaagc acctgctgga tgctaaacac     7260

tattttcagt gcttgaatca taaataagaa taaaacatgt atcttattcc ccacaagagt     7320

ccaagtaaaa aataacagtt aattataatg tgctctgtcc cccaggctgg agtgcagtgg     7380

cacgatctca gctcactgca acctccgcct cccgggttca agcaattctc ctgcctcagc     7440

caccctaata gctgggatta caggtgcaca ccaccatgcc aggctaattt ttgtactttt     7500

tgtagaggca gggtatcacc atgttgtcca agatggtctt gaactcctga gctccaagca     7560

gtccacccac ctcagcctcc caaagtgcta tctgcggccg cctatctgta ccactagtct     7620

cgagaagctt tcattaaaaa aagtctaacc agctgcattc gactttgact gcagcagctg     7680

gttagaaggt tctactggag gagggtccca gcccattgct aaattaacat caggctctga     7740

gactggcagt atatctctaa cagtggttga tgctatcttc tggaacttgc ctgctacatt     7800

gagaccactg acccatacat aggaagccca tagctctgtc ctgaactgtt aggccactgg     7860

tccagagagt gtgcatctcc tttgatcctc ataataaccc tatgagatag acacaattat     7920

tactcttact ttatagatga tgatcctgaa aacataggag tcaaggcact tgcccctagc     7980

tgggggtata ggggagcagt cccatgtagt agtagaatga aaaatgctgc tatgctgtgc     8040

ctcccccacc tttcccatgt ctgccctcta ctcatggtct atctctcctg gctcctggga     8100

gtcatggact ccacccagca ccaccaacct gacctaacca cctatctgag cctgccagcc     8160

tataacccat ctgggccctg atagctggtg gccagccctg accccacccc accctccctg     8220

gaacctctga tagacacatc tggcacacca gctcgcaaag tcaccgtgag ggtcttgtgt     8280

ttgctgagtc aaaattcctt gaaatccaag tccttagaga ctcctgctcc caaatttaca     8340

gtcatagact tcttcatggc tgtctccttt atccacagaa tgattccttt gcttcattgc     8400

cccatccatc tgatcctcct catcagtgca gcacagggcc catgagcagt agctgcagag     8460

tctcacatag gtctggcact gcctctgaca tgtccgacct taggcaaatg cttgactctt     8520

ctgagctcag tcttgtcatg gcaaaataaa gataataata gtgttttttt atggagttag     8580

cgtgaggatg gaaaacaata gcaaaattga ttagactata aaaggtctca acaaatagta     8640

gtagatttta tcatccatta atccttccct ctcctctctt actcatccca tcacgtatgc     8700

ctcttaattt tcccttacct ataataagag ttattcctct tattatattc ttcttatagt     8760

gattctggat attaaagtgg gaatgagggg caggccacta acgaagaaga tgtttctcaa     8820

agaagccatt ctccccacat agatcatctc agcagggttc aggaagataa aggaggatca     8880

aggtcgaagg taggaactaa ggaagaacac tgggcaagtg gatcctgagc cccttttcct     8940

ctaactgaaa gaaggaaaaa aaaaatggaa cccaaaatat tctacatagt ttccatgtca     9000

cagccagggc tgggcagtct cctgttattt cttttaaaat aaatatatca tttaaatgca     9060

taaataagca aaccctgctc gggaatggga gggagagtct ctggagtcca ccccttctcg     9120

gccctggctc tgcagatagt gctatcaaag ccctgacaga gccctgccca ttgctgggcc     9180

ttggagtgag tcagcctagt agagaggcag ggcaagccat ctcatagctg ctgagtggga     9240

gagagaaaag ggctcattgt ctataaactc aggtcatggc tattcttatt ctcacactaa     9300

gaaaaagaat gagatgtcta catataccct gcgtcccctc ttgtgtactg gggcccccaa     9360

gagctctcta aaagtgatgg caaagtcatt gcgctagatg ccatcccatc tattataaac     9420

ctgcatttgt ctccacacac cagtcatgga caataaccct cctcccaggt ccacgtgctt     9480

gtctttgtat aatactcaag taatttcgga aaatgtattc tttcaatctt gttctgttat     9540

tcctgtttca atggcttagt agaaaaagta catacttgtt ttcccataaa ttgacaatag     9600

acaatttcac atcaatgtct atatgggtcg ttgtgtttgc tgtgtttgca aaaactcaca     9660

ataactttat attgttacta ctctaagaaa gttacaacat ggtgaataca agagaaagct     9720

attacaagtc cagaaaataa aagttatcat cttgaggcct cagctttcta ggaataatat     9780

caatattaca aaattaatct aacaattatg aacagcaatg agataatatg tacaaagtac     9840

ccagacctat gtggtagagc atcaaggaag cgcattgcgg agcagttttt tgtttgtttg     9900

tttttgtatt ctgtttcgtg aggcaaggtt tcactctgct gtccaggctg gagtgcagtg     9960

gcaagatcat gtctcactgc agccttgaca ctacacgtgc tttaagacca atgacttaca    10020

aggcagctgt agatcttagc cactttttaa aagaaaaggg gggactggaa gggctaattc    10080

actcccaacg aagacaagat ctgctttttg ctagcgcggc cgctctagac tagtggggcc    10140

cgtgcaattg aagccggctg gcgccaagct tctctgcagg atgtgcgggc caggcccccg    10200

agggccttat cggccccaga ggcgcttgct gtcgggccgg gcgctcccgg cacgggcggg    10260

cggaggggtg gcgcccgcct ggggaccgca gattacaaga gcacctcctc ccccaacccc    10320

aggaggcccc gctccccagg cctcggccgg cgcggacccc tggttgcccc ggatgtacag    10380

gcatgcgtcg acctcgaggg ggggcccggt accgctagca ctgggtctct ctggttagac    10440

cagatctgag cctgggagct ctctggctaa ctagggaacc cactgcttaa gcctcaataa    10500

agcttgcctt gagtgcttca agtagtgtgt gcccgtctgt tgtgtgactc tggtaactag    10560

agatccctca gaccctttta gtcagtgtgg aaaatctcta gcaggtcgac aatcaacctc    10620

tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct ccttttacgc    10680

tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt atggctttca    10740

ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg tggcccgttg    10800

tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact ggttggggca    10860

ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct attgccacgg    10920

cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg ttgggcactg    10980

acaattccgt ggtgttgtcg gggaagctga cgtcctttcc atggctgctc gcctgtgttg    11040

ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc aatccagcgg    11100

accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt cgccttcgcc    11160

ctcagacgag tcggatctcc ctttgggccg cctccccgcc tggaattcga gctcggtacc    11220

tgatcagcct cgactgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccgtg    11280

ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt    11340

gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggacagc    11400

aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg ctctatggct    11460

tctgaggaaa gaaccagctg gggctcgaga tccactagtt ctagcctcga ggctagagcg    11520

gccgccaccg cggtagtagt tcatgtcatc ttattattca gtatttataa cttgcaaaga    11580

aatgaatatc agagagtgag aggaacttgt ttattgcagc ttataatggt tacaaataaa    11640

gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt    11700

tgtccaaact catcaatgta tcttatcatg tctggctcta gctatcccgc ccctaactcc    11760

gcccagttcc gcccattctc cgccccatgg ctgactaatt ttttttattt atgcagaggc    11820

cgaggccgcc tcggcctctg agctattcca gaagtagtga ggaggctttt ttggaggcct    11880

aggcttttgc gtcgagacgt acccaattcg ccctatagtg agtcgtatta cgcgcgctca    11940

ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg gcgttaccca acttaatcgc    12000

cttgcagcac atcccccttt cgccagctgg cgtaatagcg aagaggcccg caccgatcgc    12060

ccttcccaac agttgcgcag cctgaatggc gaatggcgcg acgcgccctg tagcggcgca    12120

ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta    12180

gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg ctttccccgt    12240

caagctctaa atcgggggct ccctttaggg ttccgattta gtgctttacg gcacctcgac    12300

cccaaaaaac ttgattaggg tgatggttca cgtagtgggc catcgccctg atagacggtt    12360

tttcgccctt tgacgttgga gtccacgttc tttaatagtg gactcttgtt ccaaactgga    12420

acaacactca accctatctc ggtctattct tttgatttat aagggatttt gccgatttcg    12480

gcctattggt taaaaaatga gctgatttaa caaaaattta acgcgaattt taacaaaata    12540

ttaacgttta caatttccca ggtggcactt ttcggggaaa tgtgcgcgga acccctattt    12600

gtttattttt ctaaatacat tcaaatatgt atccgctcat gagacaataa ccctgataaa    12660

tgcttcaata atattgaaaa aggaagagta tgagtattca acatttccgt gtcgccctta    12720

ttcccttttt tgcggcattt tgccttcctg tttttgctca cccagaaacg ctggtgaaag    12780

taaaagatgc tgaagatcag ttgggtgcac gagtgggtta catcgaactg gatctcaaca    12840

gcggtaagat ccttgagagt tttcgccccg aagaacgttt tccaatgatg agcactttta    12900

aagttctgct atgtggcgcg gtattatccc gtattgacgc cgggcaagag caactcggtc    12960

gccgcataca ctattctcag aatgacttgg ttgagtactc accagtcaca gaaaagcatc    13020

ttacggatgg catgacagta agagaattat gcagtgctgc cataaccatg agtgataaca    13080

ctgcggccaa cttacttctg acaacgatcg gaggaccgaa ggagctaacc gcttttttgc    13140

acaacatggg ggatcatgta actcgccttg atcgttggga accggagctg aatgaagcca    13200

taccaaacga cgagcgtgac accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac    13260

tattaactgg cgaactactt actctagctt cccggcaaca attaatagac tggatggagg    13320

cggataaagt tgcaggacca cttctgcgct cggcccttcc ggctggctgg tttattgctg    13380

ataaatctgg agccggtgag cgtgggtctc gcggtatcat tgcagcactg gggccagatg    13440

gtaagccctc ccgtatcgta gttatctaca cgacggggag tcaggcaact atggatgaac    13500

gaaatagaca gatcgctgag ataggtgcct cactgattaa gcattggtaa               13550


<210>  5
<211>  147
<212>  PRT
<213>  human

<400>  5

Met Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Thr Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp 
65                  70                  75                  80  


Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln 
        115                 120                 125             


Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  6
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  6
caagaaagtg ctcggtgcct                                                   20


<210>  7
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  7
gcaaaggtgc ccttgaggt                                                    19


<210>  8
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  8
tagtgatggc ctggctcacc tggac                                             25


<210>  9
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  9
tccccaccac caagacctac                                                   20


<210>  10
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  10
ccttaacctg ggcagagcc                                                    19


<210>  11
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  11
tcccgcactt cgacctgagc ca                                                22


<210>  12
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  12
tggcaagaag gtgctgactt c                                                 21


<210>  13
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  13
tcactcagct gggcaaagg                                                    19


<210>  14
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  14
tgggagatgc cataaagcac ctgg                                              24


<210>  15
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  15
tgcgaacttg aacgtcagga gtct                                              24


<210>  16
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  16
tgcgaacttg aacgtcagga gtct                                              24


<210>  17
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  17
agctgctttc ggctttctcc ctta                                              24


<210>  18
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  18
cctttgcatt tgcagcagtt cagc                                              24


<210>  19
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  19
tcaaccgatc atccctcaca ctct                                              24


<210>  20
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  20
aatcagcagc gcttccattc aagg                                              24


<210>  21
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  21
gctgcctcca cccaagtg                                                     18


<210>  22
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  22
accaactctg ggcagtcaca t                                                 21


<210>  23
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  23
agcaaccacc catgcctgcc                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  24
ctcgggccaa aggcctcacg                                                   20


<210>  25
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  25
cggctgttgg gcactga                                                      17


<210>  26
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  26
ggaaggtccg ctggattga                                                    19


<210>  27
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  27
atggctgctc gcctgtgttg cc                                                22


<210>  28
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  28
aaggtgagca aggtggagat tc                                                22


<210>  29
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  29
ttccgagttc agctccaact g                                                 21


