                         SEQUENCE LISTING

<110>  Yeda Research and Development Co. Ltd.
       SAMUELS, Yardena
       ARAFEH, Rand
       QUTOB, Nouar
 
<120>  USE OF RASA2 AS A PROGNOSTIC AND THERAPEUTIC MARKER FOR MELANOMA

<130>  64713

<150>  US 62/105,896
<151>  2015-01-21

<150>  US 62/233,359
<151>  2015-09-27

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  1
cattaatatg ttctttcaga ttgaagt                                           27


<210>  2
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  2
ttctcagcac aactctgcac t                                                 21


<210>  3
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  3
gaaggggagc atcacacact                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  4
gcctccctga gaaagtgtca                                                   20


<210>  5
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  5
ttcaaaatga cccagacaaa tg                                                22


<210>  6
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  6
cagagaatca agacagacaa aatca                                             25


<210>  7
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  7
aatgctggtt tatcttctgg aaa                                               23


<210>  8
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  8
cccttatcct taatgcccat a                                                 21


<210>  9
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  9
ctgcagacac atggaaaaca a                                                 21


<210>  10
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  10
tcagcagttt ttctacagtt gga                                               23


<210>  11
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  11
caacatagat gaaggtgctc taaatc                                            26


<210>  12
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  12
ggtaagggag ggtgcaaag                                                    19


<210>  13
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  13
ttcctctgct tttatccaca a                                                 21


<210>  14
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  14
gttaacatca cacctacaca tgc                                               23


<210>  15
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  15
agtgaggtat gtatatggtg ttgctaa                                           27


<210>  16
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  16
gggtgtggtg aaggaagaac                                                   20


<210>  17
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  17
tgtaatatct atgctttttg tttcctg                                           27


<210>  18
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  18
ctgttcaatc actagcctgt aaaa                                              24


<210>  19
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  19
aaggatatga tttaacacga aacg                                              24


<210>  20
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  20
aaggtaggtg aatactgttt gatagc                                            26


<210>  21
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  21
gcaagctttt aaataaatgg taaaaat                                           27


<210>  22
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  22
ttctaagtag tctgacaaaa tgaaaat                                           27


<210>  23
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  23
aaatagactg aacactttag aagcaaat                                          28


<210>  24
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  24
agcccaaagg aatggctaga                                                   20


<210>  25
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  25
tgaatgagtt tggaaaaggg taa                                               23


<210>  26
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  26
cacgcctgta atcccagaaa                                                   20


<210>  27
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  27
tcttcttgca ggtgaggaaa g                                                 21


<210>  28
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  28
cccctttgta ctcatcacca                                                   20


<210>  29
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  29
aattccttag gctggtgagt tg                                                22


<210>  30
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  30
tttaaaactt ctagagacag ggtctt                                            26


<210>  31
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  31
caagagagcc tagtaaggag gtg                                               23


<210>  32
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  32
gctgtcaaaa caggggcata                                                   20


<210>  33
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  33
tcatttgtaa attagggatt tcctc                                             25


<210>  34
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  34
ttttgctatc catgactgtt gc                                                22


<210>  35
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  35
gggggaacca ctcatttgac                                                   20


<210>  36
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  36
agttaaagaa actcccatgt tctaa                                             25


<210>  37
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  37
tggtcacttt agaagacaat caaaat                                            26


<210>  38
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  38
tggacagata gcttgggact g                                                 21


<210>  39
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  39
aacaattccc tccctttatt ctt                                               23


<210>  40
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  40
tcagataata cgtggccttt atga                                              24


<210>  41
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  41
agtcacataa caaccaaaac tctcc                                             25


<210>  42
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  42
gaataatcat caggctcttt ctgt                                              24


<210>  43
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  43
agaggcattt ttcattgaca ttc                                               23


<210>  44
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  44
acaaagagca cttggagtgg                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  45
tgatggcaag ggttttcttg                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  46
gcaggcactg atggtagtga                                                   20


<210>  47
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  47
atcatctaga gccaccatgg attacaagga tgacgacgat aaggcggcgg cggcgcctgc       60


<210>  48
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  48
tggtcagcgg ccgcctaaga tgctttccca acaattggat tttcc                       45


<210>  49
<211>  850
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ala Ala Ala Ala Pro Ala Ala Ala Ala Ala Ser Ser Glu Ala Pro 
1               5                   10                  15      


Ala Ala Ser Ala Thr Ala Glu Pro Glu Ala Gly Asp Gln Asp Ser Arg 
            20                  25                  30          


Glu Val Arg Val Leu Gln Ser Leu Arg Gly Lys Ile Cys Glu Ala Lys 
        35                  40                  45              


Asn Leu Leu Pro Tyr Leu Gly Pro His Lys Met Arg Asp Cys Phe Cys 
    50                  55                  60                  


Thr Ile Asn Leu Asp Gln Glu Glu Val Tyr Arg Thr Gln Val Val Glu 
65                  70                  75                  80  


Lys Ser Leu Ser Pro Phe Phe Ser Glu Glu Phe Tyr Phe Glu Ile Pro 
                85                  90                  95      


Arg Thr Phe Gln Tyr Leu Ser Phe Tyr Val Tyr Asp Lys Asn Val Leu 
            100                 105                 110         


Gln Arg Asp Leu Arg Ile Gly Lys Val Ala Ile Lys Lys Glu Asp Leu 
        115                 120                 125             


Cys Asn His Ser Gly Lys Glu Thr Trp Phe Ser Leu Gln Pro Val Asp 
    130                 135                 140                 


Ser Asn Ser Glu Val Gln Gly Lys Val His Leu Glu Leu Lys Leu Asn 
145                 150                 155                 160 


Glu Leu Ile Thr Glu Asn Gly Thr Val Cys Gln Gln Leu Val Val His 
                165                 170                 175     


Ile Lys Ala Cys His Gly Leu Pro Leu Ile Asn Gly Gln Ser Cys Asp 
            180                 185                 190         


Pro Tyr Ala Thr Val Ser Leu Val Gly Pro Ser Arg Asn Asp Gln Lys 
        195                 200                 205             


Lys Thr Lys Val Lys Lys Lys Thr Ser Asn Pro Gln Phe Asn Glu Ile 
    210                 215                 220                 


Phe Tyr Phe Glu Val Thr Arg Ser Ser Ser Tyr Thr Arg Lys Ser Gln 
225                 230                 235                 240 


Phe Gln Val Glu Glu Glu Asp Ile Glu Lys Leu Glu Ile Arg Ile Asp 
                245                 250                 255     


Leu Trp Asn Asn Gly Asn Leu Val Gln Asp Val Phe Leu Gly Glu Ile 
            260                 265                 270         


Lys Val Pro Val Asn Val Leu Arg Thr Asp Ser Ser His Gln Ala Trp 
        275                 280                 285             


Tyr Leu Leu Gln Pro Arg Asp Asn Gly Asn Lys Ser Ser Lys Thr Asp 
    290                 295                 300                 


Asp Leu Gly Ser Leu Arg Leu Asn Ile Cys Tyr Thr Glu Asp Tyr Val 
305                 310                 315                 320 


Leu Pro Ser Glu Tyr Tyr Gly Pro Leu Lys Thr Leu Leu Leu Lys Ser 
                325                 330                 335     


Pro Asp Val Gln Pro Ile Ser Ala Ser Ala Ala Tyr Ile Leu Ser Glu 
            340                 345                 350         


Ile Cys Arg Asp Lys Asn Asp Ala Val Leu Pro Leu Val Arg Leu Leu 
        355                 360                 365             


Leu His His Asp Lys Leu Val Pro Phe Ala Thr Ala Val Ala Glu Leu 
    370                 375                 380                 


Asp Leu Lys Asp Thr Gln Asp Ala Asn Thr Ile Phe Arg Gly Asn Ser 
385                 390                 395                 400 


Leu Ala Thr Arg Cys Leu Asp Glu Met Met Lys Ile Val Gly Gly His 
                405                 410                 415     


Tyr Leu Lys Val Thr Leu Lys Pro Ile Leu Asp Glu Ile Cys Asp Ser 
            420                 425                 430         


Ser Lys Ser Cys Glu Ile Asp Pro Ile Lys Leu Lys Glu Gly Asp Asn 
        435                 440                 445             


Val Glu Asn Asn Lys Glu Asn Leu Arg Tyr Tyr Val Asp Lys Leu Phe 
    450                 455                 460                 


Asn Thr Ile Val Lys Ser Ser Met Ser Cys Pro Thr Val Met Cys Asp 
465                 470                 475                 480 


Ile Phe Tyr Ser Leu Arg Gln Met Ala Thr Gln Arg Phe Pro Asn Asp 
                485                 490                 495     


Pro His Val Gln Tyr Ser Ala Val Ser Ser Phe Val Phe Leu Arg Phe 
            500                 505                 510         


Phe Ala Val Ala Val Val Ser Pro His Thr Phe His Leu Arg Pro His 
        515                 520                 525             


His Pro Asp Ala Gln Thr Ile Arg Thr Leu Thr Leu Ile Ser Lys Thr 
    530                 535                 540                 


Ile Gln Thr Leu Gly Ser Trp Gly Ser Leu Ser Lys Ser Lys Ser Ser 
545                 550                 555                 560 


Phe Lys Glu Thr Phe Met Cys Glu Phe Phe Lys Met Phe Gln Glu Glu 
                565                 570                 575     


Gly Tyr Ile Ile Ala Val Lys Lys Phe Leu Asp Glu Ile Ser Ser Thr 
            580                 585                 590         


Glu Thr Lys Glu Ser Ser Gly Thr Ser Glu Pro Val His Leu Lys Glu 
        595                 600                 605             


Gly Glu Met Tyr Lys Arg Ala Gln Gly Arg Thr Arg Ile Gly Lys Lys 
    610                 615                 620                 


Asn Phe Lys Lys Arg Trp Phe Cys Leu Thr Ser Arg Glu Leu Thr Tyr 
625                 630                 635                 640 


His Lys Gln Pro Gly Ser Lys Asp Ala Ile Tyr Thr Ile Pro Val Lys 
                645                 650                 655     


Asn Ile Leu Ala Val Glu Lys Leu Glu Glu Ser Ser Phe Asn Lys Lys 
            660                 665                 670         


Asn Met Phe Gln Val Ile His Thr Glu Lys Pro Leu Tyr Val Gln Ala 
        675                 680                 685             


Asn Asn Cys Val Glu Ala Asn Glu Trp Ile Asp Val Leu Cys Arg Val 
    690                 695                 700                 


Ser Arg Cys Asn Gln Asn Arg Leu Ser Phe Tyr His Pro Ser Val Tyr 
705                 710                 715                 720 


Leu Asn Gly Asn Trp Leu Cys Cys Gln Glu Thr Gly Glu Asn Thr Leu 
                725                 730                 735     


Gly Cys Lys Pro Cys Thr Ala Gly Val Pro Ala Asp Ile Gln Ile Asp 
            740                 745                 750         


Ile Asp Glu Asp Arg Glu Thr Glu Arg Ile Tyr Ser Leu Phe Thr Leu 
        755                 760                 765             


Ser Leu Leu Lys Leu Gln Lys Met Glu Glu Ala Cys Gly Thr Ile Ala 
    770                 775                 780                 


Val Tyr Gln Gly Pro Gln Lys Glu Pro Asp Asp Tyr Ser Asn Phe Val 
785                 790                 795                 800 


Ile Glu Asp Ser Val Thr Thr Phe Lys Thr Ile Gln Gln Ile Lys Ser 
                805                 810                 815     


Ile Ile Glu Lys Leu Asp Glu Pro His Glu Lys Tyr Arg Lys Lys Arg 
            820                 825                 830         


Ser Ser Ser Ala Lys Tyr Gly Ser Lys Glu Asn Pro Ile Val Gly Lys 
        835                 840                 845             


Ala Ser 
    850 


<210>  50
<211>  2592
<212>  DNA
<213>  Homo sapiens

<400>  50
atggcggcgg cggcgcctgc tgctgcggcg gcttcttccg aggcgccagc ggcgagtgcg       60

actgcagagc ccgaggccgg ggaccaggac agtcgcgagg ttcgagtgtt gcagagcctg      120

cggggcaaga tctgtgaagc aaaaaattta ttgccatatc ttggacccca caaaatgaga      180

gattgtttct gtaccataaa tttggaccag gaagaagttt atcgtaccca agttgtggaa      240

aaatctttaa gcccattttt cagtgaagaa ttttactttg agattccaag aactttccag      300

tatttgtctt tctatgttta tgataagaat gttttacaaa gagatctccg tataggaaaa      360

gtagccatca aaaaagaaga cttgtgtaat cacagtggca aagaaacttg gttttcatta      420

cagcctgttg actccaattc agaggttcag ggtaaagttc accttgaatt aaaactgaat      480

gaactgataa cggagaatgg aactgtatgc cagcagcttg ttgtacacat caaggcatgc      540

catgggttgc ctctcataaa tggccaaagc tgtgaccctt atgcaacagt ttctctagtg      600

ggcccttcta ggaatgacca aaagaagaca aaagtaaaga agaaaacaag caatccgcag      660

tttaatgaaa tcttttattt tgaagtaacc agatccagta gttacaccag aaagtcccag      720

ttccaggtag aagaggagga cattgaaaag ctagaaatca ggatcgactt gtggaacaat      780

ggaaacctag tccaagatgt tttcctaggt gagattaagg ttcctgtgaa cgtattaaga      840

actgattcct ctcatcaagc ctggtacttg ctacagccaa gagacaatgg aaacaagtca      900

tccaaaactg atgacctggg gtctcttcga ttaaatatat gttatacaga agactacgtg      960

cttccttcag agtactatgg tcctttgaaa actttgctgc taaaatcacc agatgttcaa     1020

ccaatatctg cctcagctgc ttacattttg agtgaaatat gtcgagataa aaatgatgct     1080

gttttgcccc ttgtacgact gctgctgcac catgataaac ttgttccttt tgccactgct     1140

gtggctgaat tagacttgaa ggatacacaa gatgcaaaca caatttttag aggaaattcc     1200

ctggctaccc gatgtctgga tgagatgatg aaaatagtgg gagggcacta cctgaaagta     1260

acattaaaac ctattcttga tgagatatgt gactcctcaa aatcctgtga aatcgatcct     1320

attaaattga aagagggaga taatgtagaa aataataagg agaatctgcg ctactatgta     1380

gacaagttat tcaatacaat tgtaaaatca agtatgagct gccccactgt aatgtgtgat     1440

atcttttatt ctctaaggca gatggctact cagagatttc ctaatgaccc tcatgttcag     1500

tattctgcag tgagcagctt tgtatttctt cgtttctttg ctgtagccgt agtatcacct     1560

catacttttc atttgcgacc tcatcatcca gatgcacaga caattagaac attaactctc     1620

atctcaaaaa ctatacaaac tttgggaagc tgggggagtc tgtccaaaag caagtcaagt     1680

ttcaaagaga cattcatgtg tgaatttttc aaaatgtttc aagaagaagg atatattata     1740

gcagttaaaa agttcttgga tgaaatttca tctactgaaa ctaaagagtc cagtggtacg     1800

agtgagcctg tgcacctgaa agaaggtgag atgtataaaa gagctcaagg aagaactcgg     1860

attggaaaaa agaattttaa gaaacgatgg ttctgcttaa caagcagaga gctcacctac     1920

cacaaacagc caggcaaaga tgcaatctac acaatcccag taaaaaacat tcttgctgtg     1980

gaaaaactgg aagagagctc tttcaacaag aaaaatatgt tccaagtaat acatacggag     2040

aaaccactct atgtccaggc aaataactgt gtagaagcta atgaatggat agacgtactc     2100

tgcagggtga gccgatgcaa tcaaaacagg ctcagttttt atcatccctc tgtgtatcta     2160

aacggaaatt ggctctgctg tcaggagact ggtgaaaaca ctctcggctg caagccatgt     2220

actgcaggtg tccctgcaga catccaaata gatattgatg aagacagaga aacagaaaga     2280

atttattccc tttttaccct cagtttactt aagctgcaga agatggaaga ggcttgtgga     2340

actattgcag tctatcaagg accacagaaa gagcctgatg attattctaa ctttgtaatc     2400

gaggattctg taacaacctt taagacaatt cagcaaataa aaagcataat tgagaagctg     2460

gatgaacctc atgaaaaata taggaagaaa agatccagta gtgcaaaata tgggagcaag     2520

gaaaatccaa ttgttgggaa agcatcttag agtttaacag attggttcag aagaactgga     2580

aaatattatt tt                                                         2592


