                         SEQUENCE LISTING

<110>  RAPPAPORT FAMILY INSTITUTE FOR RESEARCH IN THE MEDICAL 
       SCIENCES
       CIECHANOVER, Aaron
       KRAVTSOVA, Yelena
       SHOMER, Inna
       COHEN, Victoria
 
<120>  UBIQUITIN LIGASE KPC1 PROMOTES PROCESSING OF P105 NF-KAPAB1 TO 
       P50, ELICITING STRONG TUMOR SUPPRESSION

<130>  P-78754-PC

<150>  62/104,883
<151>  2015-01-19

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  969
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Glu Asp Asp Pro Tyr Leu Gly Arg Pro Glu Gln Met Phe His 
1               5                   10                  15      


Leu Asp Pro Ser Leu Thr His Thr Ile Phe Asn Pro Glu Val Phe Gln 
            20                  25                  30          


Pro Gln Met Ala Leu Pro Thr Ala Asp Gly Pro Tyr Leu Gln Ile Leu 
        35                  40                  45              


Glu Gln Pro Lys Gln Arg Gly Phe Arg Phe Arg Tyr Val Cys Glu Gly 
    50                  55                  60                  


Pro Ser His Gly Gly Leu Pro Gly Ala Ser Ser Glu Lys Asn Lys Lys 
65                  70                  75                  80  


Ser Tyr Pro Gln Val Lys Ile Cys Asn Tyr Val Gly Pro Ala Lys Val 
                85                  90                  95      


Ile Val Gln Leu Val Thr Asn Gly Lys Asn Ile His Leu His Ala His 
            100                 105                 110         


Ser Leu Val Gly Lys His Cys Glu Asp Gly Ile Cys Thr Val Thr Ala 
        115                 120                 125             


Gly Pro Lys Asp Met Val Val Gly Phe Ala Asn Leu Gly Ile Leu His 
    130                 135                 140                 


Val Thr Lys Lys Lys Val Phe Glu Thr Leu Glu Ala Arg Met Thr Glu 
145                 150                 155                 160 


Ala Cys Ile Arg Gly Tyr Asn Pro Gly Leu Leu Val His Pro Asp Leu 
                165                 170                 175     


Ala Tyr Leu Gln Ala Glu Gly Gly Gly Asp Arg Gln Leu Gly Asp Arg 
            180                 185                 190         


Glu Lys Glu Leu Ile Arg Gln Ala Ala Leu Gln Gln Thr Lys Glu Met 
        195                 200                 205             


Asp Leu Ser Val Val Arg Leu Met Phe Thr Ala Phe Leu Pro Asp Ser 
    210                 215                 220                 


Thr Gly Ser Phe Thr Arg Arg Leu Glu Pro Val Val Ser Asp Ala Ile 
225                 230                 235                 240 


Tyr Asp Ser Lys Ala Pro Asn Ala Ser Asn Leu Lys Ile Val Arg Met 
                245                 250                 255     


Asp Arg Thr Ala Gly Cys Val Thr Gly Gly Glu Glu Ile Tyr Leu Leu 
            260                 265                 270         


Cys Asp Lys Val Gln Lys Asp Asp Ile Gln Ile Arg Phe Tyr Glu Glu 
        275                 280                 285             


Glu Glu Asn Gly Gly Val Trp Glu Gly Phe Gly Asp Phe Ser Pro Thr 
    290                 295                 300                 


Asp Val His Arg Gln Phe Ala Ile Val Phe Lys Thr Pro Lys Tyr Lys 
305                 310                 315                 320 


Asp Ile Asn Ile Thr Lys Pro Ala Ser Val Phe Val Gln Leu Arg Arg 
                325                 330                 335     


Lys Ser Asp Leu Glu Thr Ser Glu Pro Lys Pro Phe Leu Tyr Tyr Pro 
            340                 345                 350         


Glu Ile Lys Asp Lys Glu Glu Val Gln Arg Lys Arg Gln Lys Leu Met 
        355                 360                 365             


Pro Asn Phe Ser Asp Ser Phe Gly Gly Gly Ser Gly Ala Gly Ala Gly 
    370                 375                 380                 


Gly Gly Gly Met Phe Gly Ser Gly Gly Gly Gly Gly Gly Thr Gly Ser 
385                 390                 395                 400 


Thr Gly Pro Gly Tyr Ser Phe Pro His Tyr Gly Phe Pro Thr Tyr Gly 
                405                 410                 415     


Gly Ile Thr Phe His Pro Gly Thr Thr Lys Ser Asn Ala Gly Met Lys 
            420                 425                 430         


His Gly Thr Met Asp Thr Glu Ser Lys Lys Asp Pro Glu Gly Cys Asp 
        435                 440                 445             


Lys Ser Asp Asp Lys Asn Thr Val Asn Leu Phe Gly Lys Val Ile Glu 
    450                 455                 460                 


Thr Thr Glu Gln Asp Gln Glu Pro Ser Glu Ala Thr Val Gly Asn Gly 
465                 470                 475                 480 


Glu Val Thr Leu Thr Tyr Ala Thr Gly Thr Lys Glu Glu Ser Ala Gly 
                485                 490                 495     


Val Gln Asp Asn Leu Phe Leu Glu Lys Ala Met Gln Leu Ala Lys Arg 
            500                 505                 510         


His Ala Asn Ala Leu Phe Asp Tyr Ala Val Thr Gly Asp Val Lys Met 
        515                 520                 525             


Leu Leu Ala Val Gln Arg His Leu Thr Ala Val Gln Asp Glu Asn Gly 
    530                 535                 540                 


Asp Ser Val Leu His Leu Ala Ile Ile His Leu His Ser Gln Leu Val 
545                 550                 555                 560 


Arg Asp Leu Leu Glu Val Thr Ser Gly Leu Ile Ser Asp Asp Ile Ile 
                565                 570                 575     


Asn Met Arg Asn Asp Leu Tyr Gln Thr Pro Leu His Leu Ala Val Ile 
            580                 585                 590         


Thr Lys Gln Glu Asp Val Val Glu Asp Leu Leu Arg Ala Gly Ala Asp 
        595                 600                 605             


Leu Ser Leu Leu Asp Arg Leu Gly Asn Ser Val Leu His Leu Ala Ala 
    610                 615                 620                 


Lys Glu Gly His Asp Lys Val Leu Ser Ile Leu Leu Lys His Lys Lys 
625                 630                 635                 640 


Ala Ala Leu Leu Leu Asp His Pro Asn Gly Asp Gly Leu Asn Ala Ile 
                645                 650                 655     


His Leu Ala Met Met Ser Asn Ser Leu Pro Cys Leu Leu Leu Leu Val 
            660                 665                 670         


Ala Ala Gly Ala Asp Val Asn Ala Gln Glu Gln Lys Ser Gly Arg Thr 
        675                 680                 685             


Ala Leu His Leu Ala Val Glu His Asp Asn Ile Ser Leu Ala Gly Cys 
    690                 695                 700                 


Leu Leu Leu Glu Gly Asp Ala His Val Asp Ser Thr Thr Tyr Asp Gly 
705                 710                 715                 720 


Thr Thr Pro Leu His Ile Ala Ala Gly Arg Gly Ser Thr Arg Leu Ala 
                725                 730                 735     


Ala Leu Leu Lys Ala Ala Gly Ala Asp Pro Leu Val Glu Asn Phe Glu 
            740                 745                 750         


Pro Leu Tyr Asp Leu Asp Asp Ser Trp Glu Asn Ala Gly Glu Asp Glu 
        755                 760                 765             


Gly Val Val Pro Gly Thr Thr Pro Leu Asp Met Ala Thr Ser Trp Gln 
    770                 775                 780                 


Val Phe Asp Ile Leu Asn Gly Lys Pro Tyr Glu Pro Glu Phe Thr Ser 
785                 790                 795                 800 


Asp Asp Leu Leu Ala Gln Gly Asp Met Lys Gln Leu Ala Glu Asp Val 
                805                 810                 815     


Lys Leu Gln Leu Tyr Lys Leu Leu Glu Ile Pro Asp Pro Asp Lys Asn 
            820                 825                 830         


Trp Ala Thr Leu Ala Gln Lys Leu Gly Leu Gly Ile Leu Asn Asn Ala 
        835                 840                 845             


Phe Arg Leu Ser Pro Ala Pro Ser Lys Thr Leu Met Asp Asn Tyr Glu 
    850                 855                 860                 


Val Ser Gly Gly Thr Val Arg Glu Leu Val Glu Ala Leu Arg Gln Met 
865                 870                 875                 880 


Gly Tyr Thr Glu Ala Ile Glu Val Ile Gln Ala Ala Ser Ser Pro Val 
                885                 890                 895     


Lys Thr Thr Ser Gln Ala His Ser Leu Pro Leu Ser Pro Ala Ser Thr 
            900                 905                 910         


Arg Gln Gln Ile Asp Glu Leu Arg Asp Ser Asp Ser Val Cys Asp Ser 
        915                 920                 925             


Gly Val Glu Thr Ser Phe Arg Lys Leu Ser Phe Thr Glu Ser Leu Thr 
    930                 935                 940                 


Ser Gly Ala Ser Leu Leu Thr Leu Asn Lys Met Pro His Asp Tyr Gly 
945                 950                 955                 960 


Gln Glu Gly Pro Leu Glu Gly Lys Ile 
                965                 


<210>  2
<211>  2910
<212>  DNA
<213>  Homo sapiens

<400>  2
atggcagaag atgatccata tttgggaagg cctgaacaaa tgtttcattt ggatccttct       60

ttgactcata caatatttaa tccagaagta tttcaaccac agatggcact gccaacagca      120

gatggcccat accttcaaat attagagcaa cctaaacaga gaggatttcg tttccgttat      180

gtatgtgaag gcccatccca tggtggacta cctggtgcct ctagtgaaaa gaacaagaag      240

tcttaccctc aggtcaaaat ctgcaactat gtgggaccag caaaggttat tgttcagttg      300

gtcacaaatg gaaaaaatat ccacctgcat gcccacagcc tggtgggaaa acactgtgag      360

gatgggatct gcactgtaac tgctggaccc aaggacatgg tggtcggctt cgcaaacctg      420

ggtatacttc atgtgacaaa gaaaaaagta tttgaaacac tggaagcacg aatgacagag      480

gcgtgtataa ggggctataa tcctggactc ttggtgcacc ctgaccttgc ctatttgcaa      540

gcagaaggtg gaggggaccg gcagctggga gatcgggaaa aagagctaat ccgccaagca      600

gctctgcagc agaccaagga gatggacctc agcgtggtgc ggctcatgtt tacagctttt      660

cttccggata gcactggcag cttcacaagg cgcctggaac ccgtggtatc agacgccatc      720

tatgacagta aagcccccaa tgcatccaac ttgaaaattg taagaatgga caggacagct      780

ggatgtgtga ctggagggga ggaaatttat cttctttgtg acaaagttca gaaagatgac      840

atccagattc gattttatga agaggaagaa aatggtggag tctgggaagg atttggagat      900

ttttccccca cagatgttca tagacaattt gccattgtct tcaaaactcc aaagtataaa      960

gatattaata ttacaaaacc agcctctgtg tttgtccagc ttcggaggaa atctgacttg     1020

gaaactagtg aaccaaaacc tttcctctac tatcctgaaa tcaaagataa agaagaagtg     1080

cagaggaaac gtcagaagct catgcccaat ttttcggata gtttcggcgg tggtagtggt     1140

gctggagctg gaggcggagg catgtttggt agtggcggtg gaggaggggg cactggaagt     1200

acaggtccag ggtatagctt cccacactat ggatttccta cttatggtgg gattactttc     1260

catcctggaa ctactaaatc taatgctggg atgaagcatg gaaccatgga cactgaatct     1320

aaaaaggacc ctgaaggttg tgacaaaagt gatgacaaaa acactgtaaa cctctttggg     1380

aaagttattg aaaccacaga gcaagatcag gagcccagcg aggccaccgt tgggaatggt     1440

gaggtcactc taacgtatgc aacaggaaca aaagaagaga gtgctggagt tcaggataac     1500

ctctttctag agaaggctat gcagcttgca aagaggcatg ccaatgccct tttcgactac     1560

gcggtgacag gagacgtgaa gatgctgctg gccgtccagc gccatctcac tgctgtgcag     1620

gatgagaatg gggacagtgt cttacactta gcaatcatcc accttcattc tcaacttgtg     1680

agggatctac tagaagtcac atctggtttg atttctgatg acattatcaa catgagaaat     1740

gatctgtacc agacgccctt gcacttggca gtgatcacta agcaggaaga tgtggtggag     1800

gatttgctga gggctggggc cgacctgagc cttctggacc gcttgggtaa ctctgttttg     1860

cacctagctg ccaaagaagg acatgataaa gttctcagta tcttactcaa gcacaaaaag     1920

gcagcactac ttcttgacca ccccaacggg gacggtctga atgccattca tctagccatg     1980

atgagcaata gcctgccatg tttgctgctg ctggtggccg ctggggctga cgtcaatgct     2040

caggagcaga agtccgggcg cacagcactg cacctggctg tggagcacga caacatctca     2100

ttggcaggct gcctgctcct ggagggtgat gcccatgtgg acagtactac ctacgatgga     2160

accacacccc tgcatatagc agctgggaga gggtccacca ggctggcagc tcttctcaaa     2220

gcagcaggag cagatcccct ggtggagaac tttgagcctc tctatgacct ggatgactct     2280

tgggaaaatg caggagagga tgaaggagtt gtgcctggaa ccacgcctct agatatggcc     2340

accagctggc aggtatttga catattaaat gggaaaccat atgagccaga gtttacatct     2400

gatgatttac tagcacaagg agacatgaaa cagctggctg aagatgtgaa gctgcagctg     2460

tataagttac tagaaattcc tgatccagac aaaaactggg ctactctggc gcagaaatta     2520

ggtctgggga tacttaataa tgccttccgg ctgagtcctg ctccttccaa aacacttatg     2580

gacaactatg aggtctctgg gggtacagtc agagagctgg tggaggccct gagacaaatg     2640

ggctacaccg aagcaattga agtgatccag gcagcctcca gcccagtgaa gaccacctct     2700

caggcccact cgctgcctct ctcgcctgcc tccacaaggc agcaaataga cgagctccga     2760

gacagtgaca gtgtctgcga cagcggcgtg gagacatcct tccgcaaact cagctttacc     2820

gagtctctga ccagtggtgc ctcactgcta actctcaaca aaatgcccca tgattatggg     2880

caggaaggac ctctagaagg caaaatttag                                      2910


<210>  3
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Glu Asp Asp Pro Tyr Leu Gly Arg Pro Glu Gln Met Phe His 
1               5                   10                  15      


Leu Asp Pro Ser Leu Thr His Thr Ile Phe Asn Pro Glu Val Phe Gln 
            20                  25                  30          


Pro Gln Met Ala Leu Pro Thr Ala Asp Gly Pro Tyr Leu Gln Ile Leu 
        35                  40                  45              


Glu Gln Pro Lys Gln Arg Gly Phe Arg Phe Arg Tyr Val Cys Glu Gly 
    50                  55                  60                  


Pro Ser His Gly Gly Leu Pro Gly Ala Ser Ser Glu Lys Asn Lys Lys 
65                  70                  75                  80  


Ser Tyr Pro Gln Val Lys Ile Cys Asn Tyr Val Gly Pro Ala Lys Val 
                85                  90                  95      


Ile Val Gln Leu Val Thr Asn Gly Lys Asn Ile His Leu His Ala His 
            100                 105                 110         


Ser Leu Val Gly Lys His Cys Glu Asp Gly Ile Cys Thr Val Thr Ala 
        115                 120                 125             


Gly Pro Lys Asp Met Val Val Gly Phe Ala Asn Leu Gly Ile Leu His 
    130                 135                 140                 


Val Thr Lys Lys Lys Val Phe Glu Thr Leu Glu Ala Arg Met Thr Glu 
145                 150                 155                 160 


Ala Cys Ile Arg Gly Tyr Asn Pro Gly Leu Leu Val His Pro Asp Leu 
                165                 170                 175     


Ala Tyr Leu Gln Ala Glu Gly Gly Gly Asp Arg Gln Leu Gly Asp Arg 
            180                 185                 190         


Glu Lys Glu Leu Ile Arg Gln Ala Ala Leu Gln Gln Thr Lys Glu Met 
        195                 200                 205             


Asp Leu Ser Val Val Arg Leu Met Phe Thr Ala Phe Leu Pro Asp Ser 
    210                 215                 220                 


Thr Gly Ser Phe Thr Arg Arg Leu Glu Pro Val Val Ser Asp Ala Ile 
225                 230                 235                 240 


Tyr Asp Ser Lys Ala Pro Asn Ala Ser Asn Leu Lys Ile Val Arg Met 
                245                 250                 255     


Asp Arg Thr Ala Gly Cys Val Thr Gly Gly Glu Glu Ile Tyr Leu Leu 
            260                 265                 270         


Cys Asp Lys Val Gln Lys Asp Asp Ile Gln Ile Arg Phe Tyr Glu Glu 
        275                 280                 285             


Glu Glu Asn Gly Gly Val Trp Glu Gly Phe Gly Asp Phe Ser Pro Thr 
    290                 295                 300                 


Asp Val His Arg Gln Phe Ala Ile Val Phe Lys Thr Pro Lys Tyr Lys 
305                 310                 315                 320 


Asp Ile Asn Ile Thr Lys Pro Ala Ser Val Phe Val Gln Leu Arg Arg 
                325                 330                 335     


Lys Ser Asp Leu Glu Thr Ser Glu Pro Lys Pro Phe Leu Tyr Tyr Pro 
            340                 345                 350         


Glu Ile Lys Asp Lys Glu Glu Val Gln Arg Lys Arg Gln Lys Leu Pro 
        355                 360                 365             


Asn Phe Ser Asp Ser Phe Gly Gly Gly Ser Gly Ala Gly Ala Gly Gly 
    370                 375                 380                 


Gly Gly Met Phe Gly Ser Gly Gly Gly Gly Gly Gly Thr Gly Ser Thr 
385                 390                 395                 400 


Gly Pro Gly Tyr Ser Phe Pro His Tyr Gly Phe Pro Thr Tyr Gly Gly 
                405                 410                 415     


Ile Thr Phe His Pro Gly Thr Thr Lys Ser Asn Ala Gly Met Lys His 
            420                 425                 430         


Gly Thr 
        


<210>  4
<211>  1314
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ser Lys Gly Ala Gly Met Ser Phe Ser Arg Lys Ser Tyr Arg 
1               5                   10                  15      


Leu Thr Ser Asp Ala Glu Lys Ser Arg Val Thr Gly Ile Val Gln Glu 
            20                  25                  30          


Lys Leu Leu Asn Asp Tyr Leu Asn Arg Ile Phe Ser Ser Ser Glu His 
        35                  40                  45              


Ala Pro Pro Ala Ala Thr Ser Arg Lys Pro Leu Asn Phe Gln Asn Leu 
    50                  55                  60                  


Pro Glu His Leu Asp Gln Leu Leu Gln Val Asp Asn Glu Glu Glu Glu 
65                  70                  75                  80  


Ser Gln Gly Gln Val Glu Gly Arg Leu Gly Pro Ser Thr Val Val Leu 
                85                  90                  95      


Asp His Thr Gly Gly Phe Glu Gly Leu Leu Leu Val Asp Asp Asp Leu 
            100                 105                 110         


Leu Gly Val Ile Gly His Ser Asn Phe Gly Thr Ile Arg Ser Thr Thr 
        115                 120                 125             


Cys Val Tyr Lys Gly Lys Trp Leu Tyr Glu Val Leu Ile Ser Ser Gln 
    130                 135                 140                 


Gly Leu Met Gln Ile Gly Trp Cys Thr Ile Ser Cys Arg Phe Asn Gln 
145                 150                 155                 160 


Glu Glu Gly Val Gly Asp Thr His Asn Ser Tyr Ala Tyr Asp Gly Asn 
                165                 170                 175     


Arg Val Arg Lys Trp Asn Val Thr Thr Thr Asn Tyr Gly Lys Ala Trp 
            180                 185                 190         


Ala Ala Gly Asp Ile Val Ser Cys Leu Ile Asp Leu Asp Asp Gly Thr 
        195                 200                 205             


Leu Ser Phe Cys Leu Asn Gly Val Ser Leu Gly Thr Ala Phe Glu Asn 
    210                 215                 220                 


Leu Ser Arg Gly Leu Gly Met Ala Tyr Phe Pro Ala Ile Ser Leu Ser 
225                 230                 235                 240 


Phe Lys Glu Ser Val Ala Phe Asn Phe Gly Ser Arg Pro Leu Arg Tyr 
                245                 250                 255     


Pro Val Ala Gly Tyr Arg Pro Leu Gln Asp Pro Pro Ser Ala Asp Leu 
            260                 265                 270         


Val Arg Ala Gln Arg Leu Leu Gly Cys Phe Arg Ala Val Leu Ser Val 
        275                 280                 285             


Glu Leu Asp Pro Val Glu Gly Arg Leu Leu Asp Lys Glu Ser Ser Lys 
    290                 295                 300                 


Trp Arg Leu Arg Gly Gln Pro Thr Val Leu Leu Thr Leu Ala His Ile 
305                 310                 315                 320 


Phe His His Phe Ala Pro Leu Leu Arg Lys Val Tyr Leu Val Glu Ala 
                325                 330                 335     


Val Leu Met Ser Phe Leu Leu Gly Ile Val Glu Lys Gly Thr Pro Thr 
            340                 345                 350         


Gln Ala Gln Ser Val Val His Gln Val Leu Asp Leu Leu Trp Leu Phe 
        355                 360                 365             


Met Glu Asp Tyr Glu Val Gln Asp Cys Leu Lys Gln Leu Met Met Ser 
    370                 375                 380                 


Leu Leu Arg Leu Tyr Arg Phe Ser Pro Ile Val Pro Asp Leu Gly Leu 
385                 390                 395                 400 


Gln Ile His Tyr Leu Arg Leu Thr Ile Ala Ile Leu Arg His Glu Lys 
                405                 410                 415     


Ser Arg Lys Phe Leu Leu Ser Asn Val Leu Phe Asp Val Leu Arg Ser 
            420                 425                 430         


Val Val Phe Phe Tyr Ile Lys Ser Pro Leu Arg Val Glu Glu Ala Gly 
        435                 440                 445             


Leu Gln Glu Leu Ile Pro Thr Thr Trp Trp Pro His Cys Ser Ser Arg 
    450                 455                 460                 


Glu Gly Lys Glu Ser Thr Glu Met Lys Glu Glu Thr Ala Glu Glu Arg 
465                 470                 475                 480 


Leu Arg Arg Arg Ala Tyr Glu Arg Gly Cys Gln Arg Leu Arg Lys Arg 
                485                 490                 495     


Ile Glu Val Val Glu Glu Leu Gln Val Gln Ile Leu Lys Leu Leu Leu 
            500                 505                 510         


Asp Asn Lys Asp Asp Asn Gly Gly Glu Ala Ser Arg Tyr Ile Phe Leu 
        515                 520                 525             


Thr Lys Phe Arg Lys Phe Leu Gln Glu Asn Ala Ser Gly Arg Gly Asn 
    530                 535                 540                 


Met Pro Met Leu Cys Pro Pro Glu Tyr Met Val Cys Phe Leu His Arg 
545                 550                 555                 560 


Leu Ile Ser Ala Leu Arg Tyr Tyr Trp Asp Glu Tyr Lys Ala Ser Asn 
                565                 570                 575     


Pro His Ala Ser Phe Ser Glu Glu Ala Tyr Ile Pro Pro Gln Val Phe 
            580                 585                 590         


Tyr Asn Gly Lys Val Asp Tyr Phe Asp Leu Gln Arg Leu Gly Gly Leu 
        595                 600                 605             


Leu Ser His Leu Arg Lys Thr Leu Lys Asp Asp Leu Ala Ser Lys Ala 
    610                 615                 620                 


Asn Ile Val Ile Asp Pro Leu Glu Leu Gln Ser Thr Ala Met Asp Asp 
625                 630                 635                 640 


Leu Asp Glu Asp Glu Glu Pro Ala Pro Ala Met Ala Gln Arg Pro Met 
                645                 650                 655     


Gln Ala Leu Ala Val Gly Gly Pro Leu Pro Leu Pro Arg Pro Gly Trp 
            660                 665                 670         


Leu Ser Ser Pro Thr Leu Gly Arg Ala Asn Arg Phe Leu Ser Thr Ala 
        675                 680                 685             


Ala Val Ser Leu Met Thr Pro Arg Arg Pro Leu Ser Thr Ser Glu Lys 
    690                 695                 700                 


Val Lys Val Arg Thr Leu Ser Val Glu Gln Arg Thr Arg Glu Asp Ile 
705                 710                 715                 720 


Glu Gly Ser His Trp Asn Glu Gly Leu Leu Leu Gly Arg Pro Pro Glu 
                725                 730                 735     


Glu Pro Glu Gln Pro Leu Thr Glu Asn Ser Leu Leu Glu Val Leu Asp 
            740                 745                 750         


Gly Ala Val Met Met Tyr Asn Leu Ser Val His Gln Gln Leu Gly Lys 
        755                 760                 765             


Met Val Gly Val Ser Asp Asp Val Asn Glu Tyr Ala Met Ala Leu Arg 
    770                 775                 780                 


Asp Thr Glu Asp Lys Leu Arg Arg Cys Pro Lys Arg Arg Lys Asp Ile 
785                 790                 795                 800 


Leu Ala Glu Leu Thr Lys Ser Gln Lys Val Phe Ser Glu Lys Leu Asp 
                805                 810                 815     


His Leu Ser Arg Arg Leu Ala Trp Val His Ala Thr Val Tyr Ser Gln 
            820                 825                 830         


Glu Lys Met Leu Asp Ile Tyr Trp Leu Leu Arg Val Cys Leu Arg Thr 
        835                 840                 845             


Ile Glu His Gly Asp Arg Thr Gly Ser Leu Phe Ala Phe Met Pro Glu 
    850                 855                 860                 


Phe Tyr Leu Ser Val Ala Ile Asn Ser Tyr Ser Ala Leu Lys Asn Tyr 
865                 870                 875                 880 


Phe Gly Pro Val His Ser Met Glu Glu Leu Pro Gly Tyr Glu Glu Thr 
                885                 890                 895     


Leu Thr Arg Leu Ala Ala Ile Leu Ala Lys His Phe Ala Asp Ala Arg 
            900                 905                 910         


Ile Val Gly Thr Asp Ile Arg Asp Ser Leu Met Gln Ala Leu Ala Ser 
        915                 920                 925             


Tyr Val Cys Tyr Pro His Ser Leu Arg Ala Val Glu Arg Ile Pro Glu 
    930                 935                 940                 


Glu Gln Arg Ile Ala Met Val Arg Asn Leu Leu Ala Pro Tyr Glu Gln 
945                 950                 955                 960 


Arg Pro Trp Ala Gln Thr Asn Trp Ile Leu Val Arg Leu Trp Arg Gly 
                965                 970                 975     


Cys Gly Phe Gly Tyr Arg Tyr Thr Arg Leu Pro His Leu Leu Lys Thr 
            980                 985                 990         


Lys Leu Glu Asp Ala Asn Leu Pro  Ser Leu Gln Lys Pro  Cys Pro Ser 
        995                 1000                 1005             


Thr Leu  Leu Gln Gln His Met  Ala Asp Leu Leu Gln  Gln Gly Pro 
    1010                 1015                 1020             


Asp Val  Ala Pro Ser Phe Leu  Asn Ser Val Leu Asn  Gln Leu Asn 
    1025                 1030                 1035             


Trp Ala  Phe Ser Glu Phe Ile  Gly Met Ile Gln Glu  Ile Gln Gln 
    1040                 1045                 1050             


Ala Ala  Glu Arg Leu Glu Arg  Asn Phe Val Asp Ser  Arg Gln Leu 
    1055                 1060                 1065             


Lys Val  Cys Ala Thr Cys Phe  Asp Leu Ser Val Ser  Leu Leu Arg 
    1070                 1075                 1080             


Val Leu  Glu Met Thr Ile Thr  Leu Val Pro Glu Ile  Phe Leu Asp 
    1085                 1090                 1095             


Trp Thr  Arg Pro Thr Ser Glu  Met Leu Leu Arg Arg  Leu Ala Gln 
    1100                 1105                 1110             


Leu Leu  Asn Gln Val Leu Asn  Arg Val Thr Ala Glu  Arg Asn Leu 
    1115                 1120                 1125             


Phe Asp  Arg Val Val Thr Leu  Arg Leu Pro Gly Leu  Glu Ser Val 
    1130                 1135                 1140             


Asp His  Tyr Pro Ile Leu Val  Ala Val Thr Gly Ile  Leu Val Gln 
    1145                 1150                 1155             


Leu Leu  Val Arg Gly Pro Ala  Ser Glu Arg Glu Gln  Ala Thr Ser 
    1160                 1165                 1170             


Val Leu  Leu Ala Asp Pro Cys  Phe Gln Leu Arg Ser  Ile Cys Tyr 
    1175                 1180                 1185             


Leu Leu  Gly Gln Pro Glu Pro  Pro Ala Pro Gly Thr  Ala Leu Pro 
    1190                 1195                 1200             


Ala Pro  Asp Arg Lys Arg Phe  Ser Leu Gln Ser Tyr  Ala Asp Tyr 
    1205                 1210                 1215             


Ile Ser  Ala Asp Glu Leu Ala  Gln Val Glu Gln Met  Leu Ala His 
    1220                 1225                 1230             


Leu Thr  Ser Ala Ser Ala Gln  Ala Ala Ala Ala Ser  Leu Pro Thr 
    1235                 1240                 1245             


Ser Glu  Glu Asp Leu Cys Pro  Ile Cys Tyr Ala His  Pro Ile Ser 
    1250                 1255                 1260             


Ala Val  Phe Gln Pro Cys Gly  His Lys Ser Cys Lys  Ala Cys Ile 
    1265                 1270                 1275             


Asn Gln  His Leu Met Asn Asn  Lys Asp Cys Phe Phe  Cys Lys Thr 
    1280                 1285                 1290             


Thr Ile  Val Ser Val Glu Asp  Trp Glu Lys Gly Ala  Asn Thr Ser 
    1295                 1300                 1305             


Thr Thr  Ser Ser Ala Ala 
    1310                 


<210>  5
<211>  3945
<212>  DNA
<213>  Homo sapiens

<400>  5
atggcatcca agggggccgg catgtctttc tcccgcaaga gctataggct gacctcagat       60

gctgagaaat ccagggtcac aggcattgtg caggagaagc tgctgaatga ctacctgaac      120

cgcatctttt cctcttctga acatgcaccc ccagcagcca ccagcaggaa acccctgaac      180

ttccagaacc tgccagaaca tttggaccag ttgctacagg tggacaatga ggaggaggaa      240

agccagggac aggttgaagg gcggcttggc ccatccactg tggtcctgga ccacacaggc      300

ggctttgagg ggcttctcct ggtggatgat gacctgctgg gggtgattgg acacagcaac      360

tttggcacca tccgctctac cacatgcgtg tacaaaggga aatggctcta cgaggtcctc      420

atctcctccc aggggctcat gcagatcggc tggtgcacca tcagctgccg cttcaaccag      480

gaggaggggg ttggagatac acacaactcc tatgcctatg atggcaaccg cgtgcgcaag      540

tggaatgtga ccacaacgaa ttatggcaag gcgtgggcag cgggggacat cgtgagctgc      600

ctgattgacc tggatgatgg cactctgtcc ttctgcctga acggtgtatc actgggcact      660

gcctttgaga acctgtccag gggcctgggt atggcctact tcccagccat cagcctctct      720

ttcaaggagt ccgtggcctt caactttggc agccgtcctc tgcgctaccc agtggcaggc      780

taccggcccc tgcaggaccc accgagtgct gacctggtgc gggcacagag gttgctgggc      840

tgcttccggg cagtgctgag tgtggagctg gaccctgtgg aggggcggct gttggacaag      900

gagagctcca agtggcggtt gcggggccag cccaccgtcc tcctcacact ggcccacatc      960

ttccatcact ttgcaccgct tctgcgcaag gtgtatctgg tggaggctgt gctcatgagc     1020

ttcttgctgg gcatcgtgga gaagggcaca cccacacagg cacagtccgt ggtgcaccag     1080

gtcctggacc tcttgtggct cttcatggag gactacgagg tacaagattg cctcaagcag     1140

ttgatgatgt ctctgcttcg gctgtaccga ttctcaccca ttgtcccaga cctgggccta     1200

cagatccatt acctgcggct cactatcgcc atcctgaggc atgagaagtc ccgcaagttt     1260

ctgcttagca atgtcctctt cgacgtgctc cgctccgtcg tcttctttta catcaagagc     1320

cccctgcgtg tggaggaggc cggcctgcag gagctcattc ccaccacctg gtggccccac     1380

tgctccagta gggagggcaa agagagcacg gagatgaagg aggagaccgc agaggagcgg     1440

ctgcggcggc gagcctacga acggggctgt cagcggctca ggaagcgcat cgaagtggtg     1500

gaagaactac aggtccagat cctgaagctg ctgctggaca ataaagatga caatgggggt     1560

gaagcttcta ggtatatctt cctgaccaag tttcgcaagt ttctgcagga gaacgccagt     1620

ggccggggga acatgcccat gctctgcccc cctgagtaca tggtctgctt cttacaccgg     1680

ctgatctctg ccctgcgcta ctattgggat gaatacaagg cttccaatcc tcatgcttcc     1740

ttcagtgagg aggcctacat cccgccccag gtcttctata atggcaaggt ggactacttt     1800

gacctgcagc gcctgggggg cctcctctcg cacctgcgga agaccctcaa agatgacctt     1860

gcttccaaag ccaacattgt gatcgaccca ctggagctcc agtcaaccgc catggatgac     1920

ctagatgagg atgaggagcc agccccagct atggcccagc gccccatgca ggccctggct     1980

gttggggggc cactgcccct gccccggccc ggctggctca gttctccaac tttgggccga     2040

gccaaccgct tcctcagcac agcggctgtg agcctcatga ccccacggcg gcctctgagc     2100

acctcggaga aagtgaaggt ccgcacgctg agcgtggagc agaggacccg tgaggacatt     2160

gaaggcagcc actggaatga gggcttgctg ctggggcggc cccccgagga gcctgagcag     2220

cccctcaccg agaactcgct gctggaagtc ctggatgggg cggtcatgat gtacaacctc     2280

agcgtacacc agcagctggg caagatggtg ggtgtctccg atgatgtcaa tgaatacgct     2340

atggctctga gggacacaga ggacaagctc cgccggtgcc ccaagaggag gaaggacatc     2400

cttgcagagt tgaccaagag ccagaaggtt ttctcagaaa agctggacca cctgagccgc     2460

cgtcttgcct gggtccatgc cactgtctac tcccaggaga agatgctgga catctactgg     2520

ctgctgcgcg tctgcctgcg gaccattgag cacggtgatc gcacagggtc tctctttgcc     2580

ttcatgcccg agttctacct gagcgtggcc atcaacagct acagtgctct caagaattac     2640

tttggtcccg tgcacagcat ggaggagctc ccaggctatg aagagaccct gacccgcctg     2700

gctgccattc tcgccaaaca ctttgccgac gcacgcattg tgggcactga catccgagac     2760

tcactgatgc aggccctggc cagctacgtg tgctacccac actccctgcg ggctgtggag     2820

cgaatccccg aggagcagcg tatcgccatg gtgaggaacc tcctggcgcc ctatgagcag     2880

cggccctggg cccagaccaa ctggatcctg gtgcggctct ggaggggctg tggcttcggg     2940

taccgctata cacggctgcc acatctgctg aaaaccaaac ttgaggacgc caatttgccc     3000

agcctccaga agccctgccc ttccaccctg ctgcagcagc acatggcgga cctcctacag     3060

cagggtcctg atgtggcacc cagcttcctc aacagcgtcc tcaatcagct caactgggcc     3120

ttctctgaat tcattggcat gatccaagag atccagcagg ctgctgagcg cctggagcgg     3180

aactttgtgg acagccggca gctcaaggta tgtgccacct gctttgacct ctcggtcagc     3240

ctgctgcgtg tcttggagat gactatcaca ctggtgcctg agatattcct tgactggacc     3300

cggcctacct ctgagatgct gctgcggcgt cttgcacagc tgctaaacca ggtgctgaac     3360

cgggtgacag ctgagaggaa cctgtttgat cgtgtggtca ccctacggct gcctggccta     3420

gagagcgtgg accactatcc cattctggtg gcagtgacgg gcatcctggt gcagctcctg     3480

gtgcgtggcc cagcctcaga gagagagcaa gccacatcag tgctcctggc agatccctgc     3540

ttccagctac gctcaatatg ctatctcctg ggacagccag agcccccagc acctggcact     3600

gctctgccag cccctgaccg gaagcgcttc tccctgcaga gctatgcgga ttatatcagt     3660

gccgatgagc tggcccaagt ggaacagatg ctggcgcacc tgacctctgc atctgcccag     3720

gcagcagctg cctccctgcc caccagtgag gaggacctct gccccatctg ctatgcccac     3780

cccatctctg ctgtgttcca gccctgtggc cacaagtcct gcaaagcctg tatcaaccag     3840

cacctgatga acaacaagga ctgcttcttc tgcaaaacca ccatcgtgtc tgtagaggac     3900

tgggagaagg gagccaatac gagtactacc tcctcagctg cctag                     3945


<210>  6
<211>  1320
<212>  PRT
<213>  Mus musculus

<400>  6

Met Ala Ser Lys Gly Thr Gly Met Ser Phe Ser Arg Lys Ser Tyr Arg 
1               5                   10                  15      


Leu Thr Ser Asp Ala Glu Lys Ser Arg Val Thr Gly Ile Val Gln Glu 
            20                  25                  30          


Lys Leu Leu Ser Asp Tyr Leu Tyr Arg Ile Phe Ser Pro Pro Asp Arg 
        35                  40                  45              


Gly Pro Ala Ala Ala Thr Ser Arg Lys Pro Leu Asn Phe His Asn Leu 
    50                  55                  60                  


Pro Glu His Val Asp Gln Leu Leu Gln Val Asp Ser Glu Asp Asn Glu 
65                  70                  75                  80  


Ser Gln Gly Gln Val Glu Gly Arg Leu Gly Pro Ser Thr Val Val Leu 
                85                  90                  95      


Asp His Thr Gly Gly Phe Glu Gly Leu Leu Leu Val Asp Asp Asp Leu 
            100                 105                 110         


Leu Gly Val Ile Gly His Ser Asn Phe Gly Thr Ile Arg Ser Thr Thr 
        115                 120                 125             


Cys Val Tyr Lys Gly Lys Trp Val Tyr Glu Val Leu Ile Ser Ser Gln 
    130                 135                 140                 


Gly Leu Met Gln Ile Gly Trp Cys Thr Ile Asn Cys Arg Phe Asn Gln 
145                 150                 155                 160 


Glu Glu Gly Val Gly Asp Thr His Asn Ser Tyr Ala Tyr Asp Gly Asn 
                165                 170                 175     


Arg Val Arg Lys Trp Asn Val Thr Thr Thr Asn Tyr Gly Lys Ala Trp 
            180                 185                 190         


Ala Ala Gly Asp Ile Val Ser Cys Leu Ile Asp Leu Asp Asp Gly Thr 
        195                 200                 205             


Leu Ser Phe Cys Leu Asn Gly Val Ser Leu Gly Thr Ala Phe Glu Asn 
    210                 215                 220                 


Leu Ser Arg Gly Leu Gly Met Ala Tyr Phe Pro Ala Ile Ser Leu Ser 
225                 230                 235                 240 


Phe Lys Glu Ser Val Ala Phe Asn Phe Gly Ser Arg Pro Leu Arg Tyr 
                245                 250                 255     


Pro Val Ala Gly Phe Arg Pro Leu Gln Asp Pro Pro Phe Ala Asp Leu 
            260                 265                 270         


Val Arg Ala Gln Arg Leu Leu Gly Cys Phe Gln Ala Val Leu Ser Val 
        275                 280                 285             


Glu Leu Asp Pro Val Glu Gly Arg Leu Val Glu Thr Glu Ser Ser Glu 
    290                 295                 300                 


Trp Gln Leu Gln Gly Gln Pro Thr Val Leu Leu Thr Leu Ala His Ile 
305                 310                 315                 320 


Phe His His Phe Ala Pro Leu Leu Arg Lys Val Tyr Leu Val Glu Ala 
                325                 330                 335     


Val Leu Met Ser Phe Leu Leu Gly Val Val Glu Lys Gly Thr Pro Glu 
            340                 345                 350         


Gln Ala Gln Ser Val Val His Gln Ile Leu Asp Leu Leu Trp Leu Phe 
        355                 360                 365             


Met Glu Asp Tyr Glu Val Gln Asp Cys Leu Lys Gln Leu Met Met Ser 
    370                 375                 380                 


Leu Leu Arg Leu Tyr Arg Phe Ser Pro Ile Val Pro Asp Leu Gly Leu 
385                 390                 395                 400 


Gln Ile His Tyr Leu Arg Leu Thr Met Ser Ile Leu Arg His Glu Lys 
                405                 410                 415     


Ser Arg Lys Phe Leu Leu Ser Asn Val Leu Phe Asp Met Leu Arg Ser 
            420                 425                 430         


Val Val Phe Phe Tyr Ile Lys Ser Pro Leu Arg Val Glu Glu Ala Gly 
        435                 440                 445             


Leu Lys Glu Leu Ile Pro Thr Thr Trp Trp Pro His Arg Ser Ser Arg 
    450                 455                 460                 


Glu Ser Arg Asp Gly Lys Glu Ala Arg Glu Glu Thr Thr Glu Glu Arg 
465                 470                 475                 480 


Gln Arg Arg Arg Ala Tyr Glu Arg Gly Cys Gln Arg Leu Lys Lys Arg 
                485                 490                 495     


Ile Glu Val Val Glu Glu Leu Gln Val Gln Ile Leu Lys Leu Leu Leu 
            500                 505                 510         


Asp Asn Lys Asp Asp Asn Gly Gly Glu Ala Ser Arg Tyr Ile Phe Leu 
        515                 520                 525             


Thr Lys Phe Arg Lys Phe Leu Gln Glu Asn Ala Ser Gly Arg Gly Asn 
    530                 535                 540                 


Thr Pro Val Leu Cys Pro Pro Glu Tyr Met Val Cys Phe Leu His Arg 
545                 550                 555                 560 


Leu Val Ser Ala Leu Arg Phe Tyr Trp Asp Glu Tyr Lys Ala Ser Asn 
                565                 570                 575     


Pro Arg Ala Ser Phe Ser Glu Glu Ala Tyr Ile Pro Pro Gln Ile Phe 
            580                 585                 590         


Tyr Asn Gly Lys Val Asp Tyr Phe Asp Leu Gln Arg Leu Gly Gly Leu 
        595                 600                 605             


Leu Ser His Leu Arg Lys Thr Leu Lys Asp Asp Leu Ala Ser Lys Ala 
    610                 615                 620                 


Asn Ile Val Ile Asp Pro Leu Glu Leu Gln Ala Ala Thr Met Asp Asp 
625                 630                 635                 640 


Leu Asp Glu Asp Glu Glu Pro Ala Pro Ser Ala Ala Gln Val Trp Gln 
                645                 650                 655     


Glu Gly Gln Arg Pro Met Gln Ala Leu Ala Ile Gly Gly Ala Leu Pro 
            660                 665                 670         


Leu Pro Arg Pro Gly Trp Leu Ser Ser Pro Thr Leu Gly Arg Ala Asn 
        675                 680                 685             


Arg Phe Leu Ser Thr Ala Ala Val Ser Leu Met Thr Pro Arg Arg Leu 
    690                 695                 700                 


Leu Ser Thr Met Glu Lys Val Lys Val Arg Ser Leu Asn Val Glu Gln 
705                 710                 715                 720 


Arg Thr Arg Glu Asp Ile Glu Gly Ser His Trp Asn Glu Gly Leu Leu 
                725                 730                 735     


Leu Gly Arg Pro Pro Glu Glu Pro Glu Gln Pro Leu Thr Glu Asn Ser 
            740                 745                 750         


Leu Leu Glu Val Leu Asp Gly Thr Val Met Met Tyr Asn Leu Ser Val 
        755                 760                 765             


His Gln Gln Leu Gly Lys Met Val Gly Val Ser Asp Asp Val Asn Glu 
    770                 775                 780                 


Tyr Ala Met Ala Leu Arg Asp Thr Glu Asp Lys Leu Arg Arg Cys Pro 
785                 790                 795                 800 


Lys Arg Arg Lys Asp Ile Leu Ala Glu Leu Thr Lys Ser Gln Lys Val 
                805                 810                 815     


Phe Ser Glu Lys Leu Asp His Leu Ser Arg Arg Leu Ala Trp Val His 
            820                 825                 830         


Ala Thr Val Tyr Ser Gln Glu Lys Met Leu Asp Ile Tyr Trp Leu Leu 
        835                 840                 845             


Arg Val Cys Leu Arg Thr Ile Glu His Gly Asp Arg Thr Gly Ser Leu 
    850                 855                 860                 


Phe Ala Phe Met Pro Glu Phe Tyr Leu Ser Val Ala Ile Asn Ser Tyr 
865                 870                 875                 880 


Ser Ala Leu Lys Asn Tyr Phe Gly Pro Val His Ser Met Glu Glu Leu 
                885                 890                 895     


Pro Gly Tyr Glu Glu Thr Leu Thr Arg Leu Ala Ala Ile Leu Ala Lys 
            900                 905                 910         


His Phe Ala Asp Pro Arg Ile Val Gly Thr Asp Ile Arg Asp Ser Leu 
        915                 920                 925             


Met Gln Ala Leu Ala Ser Tyr Val Cys Tyr Pro His Ser Leu Arg Ala 
    930                 935                 940                 


Val Glu Arg Ile Pro Glu Glu Gln Arg Ile Ala Met Val Arg Asn Leu 
945                 950                 955                 960 


Leu Ala Pro Tyr Glu Gln Arg Pro Trp Ala Gln Thr Asn Trp Ile Leu 
                965                 970                 975     


Val Arg Leu Trp Arg Gly Cys Gly Phe Gly Tyr Arg Tyr Thr Arg Leu 
            980                 985                 990         


Pro His Leu Leu Lys Thr Lys Pro  Glu Asp Ala Asn Leu  Pro Ser Leu 
        995                 1000                 1005             


Gln Lys  Pro Cys Pro Ser Thr  Leu Leu Gln Gln His  Met Ala Asp 
    1010                 1015                 1020             


Leu Leu  Arg Gln Gly Ser Asp  Val Ala Pro Ser Phe  Leu Asn Ser 
    1025                 1030                 1035             


Val Leu  Asn Gln Leu Asn Trp  Ala Phe Ser Glu Phe  Ile Gly Met 
    1040                 1045                 1050             


Ile Gln  Glu Ile Gln Gln Ala  Ala Glu Arg Leu Glu  Arg Asn Phe 
    1055                 1060                 1065             


Val Asp  Ser Arg Gln Leu Lys  Val Cys Ala Thr Cys  Phe Asp Leu 
    1070                 1075                 1080             


Ser Val  Ser Leu Leu Arg Val  Leu Glu Met Thr Ile  Thr Leu Val 
    1085                 1090                 1095             


Pro Glu  Ile Phe Leu Asp Trp  Ser Arg Pro Thr Ser  Glu Met Leu 
    1100                 1105                 1110             


Leu Arg  Arg Leu Ala Gln Leu  Leu Asn Gln Val Leu  Asn Arg Val 
    1115                 1120                 1125             


Thr Ala  Glu Arg Asn Leu Phe  Asp Arg Val Val Thr  Leu Arg Leu 
    1130                 1135                 1140             


Pro Gly  Leu Glu Ser Val Asp  His Tyr Pro Ile Leu  Val Ala Val 
    1145                 1150                 1155             


Thr Gly  Ile Leu Val Arg Leu  Leu Val His Gly Pro  Thr Ser Glu 
    1160                 1165                 1170             


Thr Glu  Gln Ala Thr Ser Val  Leu Leu Ala Asp Pro  Cys Phe Gln 
    1175                 1180                 1185             


Leu Arg  Ser Ile Cys Tyr Leu  Leu Gly Gln Pro Glu  Pro Leu Ala 
    1190                 1195                 1200             


Pro Gly  Thr Thr Leu Pro Ala  Pro Asp Arg Lys Arg  Phe Ser Leu 
    1205                 1210                 1215             


Gln Ser  Tyr Thr Asp Tyr Ile  Ser Ala Glu Glu Leu  Ala Gln Val 
    1220                 1225                 1230             


Glu Gln  Met Leu Ala His Leu  Thr Ala Ala Ser Ala  Gln Ala Ala 
    1235                 1240                 1245             


Ala Ala  Ser Leu Pro Thr Asn  Glu Glu Asp Leu Cys  Pro Ile Cys 
    1250                 1255                 1260             


Tyr Ala  His Pro Ile Ser Ala  Val Phe Gln Pro Cys  Gly His Lys 
    1265                 1270                 1275             


Ser Cys  Lys Ala Cys Ile Asn  Gln His Leu Met Asn  Asn Lys Asp 
    1280                 1285                 1290             


Cys Phe  Phe Cys Lys Ala Thr  Ile Val Ser Val Glu  Asp Trp Asp 
    1295                 1300                 1305             


Lys Ala  Ala Asn Thr Ser Ala  Met Ser Ser Ala Ala  
    1310                 1315                 1320 


<210>  7
<211>  3945
<212>  DNA
<213>  Mus musculus

<400>  7
atggcgtcca aggggactgg catgtcgttc tcccgaaaga gctataggct gacctcagat       60

gctgagaagt ccagggtcac aggcatcgtg caagagaaac tactgagcga ctatctgtac      120

cgcatctttt cccctcctga ccgtggaccc gccgcagcca ccagcaggaa accgctaaac      180

ttccataacc tgcctgagca cgtggaccag ctgctacagg tggacagtga agacaacgag      240

agccagggac aagttgaagg tcgacttggc ccatctactg tggtcctaga ccacacagga      300

ggctttgagg ggcttctcct tgtggatgat gacctcctgg gggtgattgg acacagcaac      360

tttggcacta tccgttctac cacatgtgtg tacaaaggga agtgggtcta cgaggtgctc      420

atctcctccc agggcctcat gcagatcggc tggtgcacca tcaactgccg ctttaatcag      480

gaggaagggg ttggagacac acataactcc tatgcctatg acggcaaccg agtgcgcaag      540

tggaatgtta ccaccacgaa ttatggcaag gcgtgggctg cgggggacat tgtcagctgc      600

ctaattgatc tggatgatgg gactctgtcc ttctgcctga atggcgtgtc actgggcact      660

gccttcgaga acctttccag gggcctagga atggcgtact tcccagccat cagcctgtca      720

ttcaaggagt ctgtggcatt caactttggc agccgtcctt tgcgctaccc agttgcgggc      780

ttccggcccc tgcaggaccc tccgtttgct gacctggtcc gggcacagag gttgctgggc      840

tgcttccagg cagtgctaag tgtggagctg gaccctgtgg aagggcggct ggtggagacg      900

gagagctctg agtggcagct gcaagggcag cccactgtcc tcctcacgct ggcccacatc      960

ttccatcact ttgcaccact gctgcgcaag gtatacctgg tggaggctgt gctaatgagc     1020

ttcctgctgg gcgttgtgga gaagggcaca ccagagcagg cgcagtctgt ggtacaccag     1080

atcttggacc tcttgtggct cttcatggag gactatgagg tacaggattg cctgaagcag     1140

ttgatgatgt cacttctacg tctctaccga ttctcgccta ttgtcccaga cctgggtcta     1200

cagatccact acctgcgcct cactatgtcc atcctgagac acgagaagtc ccgcaagttc     1260

ctgcttagca atgtcctttt tgacatgctc cggtccgtgg tcttctttta tattaagagt     1320

cccctgcgtg tggaggaagc tggcctgaag gaactcattc ccaccacctg gtggccccat     1380

cgctccagca gggagagcag agacggtaag gaagcaaggg aggagaccac cgaagagcgg     1440

cagcggaggc gagcctatga gcgtggctgc caaagactca agaaacgcat tgaagtggtg     1500

gaagaactgc aggtccagat cctgaagctg ctgttggaca ataaagatga caatgggggt     1560

gaagcttcta ggtacatctt tctgacaaaa ttccgaaagt tcctgcagga gaatgccagc     1620

ggccggggga acacacccgt gctctgcccc cctgagtaca tggtctgctt cctacaccgg     1680

ctggtgtctg ccttgcgctt ctattgggat gaatacaaag cttccaaccc ccgtgcttcc     1740

ttcagtgagg aggcttacat cccgccccag atcttctata atggcaaggt ggactacttt     1800

gaccttcagc gccttggggg cctcctctca caccttcgaa agacccttaa agatgacctt     1860

gcttccaaag ccaacatcgt gatcgacccc ctggagctcc aggcagccac catggatgac     1920

ctggatgagg atgaagagcc tgccccctca gcggcccagc gtccgatgca agccctggcc     1980

atcggagggg cactgcccct gccccggcca ggctggctca gttctccaac cctgggcaga     2040

gccaaccgct tcctcagcac ggcagctgtg agcctcatga ccccacggcg gcttctgagc     2100

accatggaga aagtcaaagt tcgctcactg aatgtggaac agaggacccg tgaggacatt     2160

gagggcagcc actggaatga gggcctgctg ttggggaggc cccctgaaga gcctgagcag     2220

ccgcttaccg agaactcgct gttggaagtc ctggatggca cagtcatgat gtataacctc     2280

agcgttcacc agcagctggg caagatggtg ggtgtgtctg atgatgtcaa cgagtatgca     2340

atggccctaa gagacacaga ggacaagctc cgtcggtgcc ctaagaggag gaaggatatc     2400

cttgcagagt tgaccaagag ccagaaggtt ttctcagaaa agctggacca cctgagccgc     2460

aggcttgcct gggtccacgc cacagtctac tcacaggaga aaatgctgga tatctactgg     2520

ttactgcgtg tctgcctacg gaccattgag catggggacc gcacggggtc tctctttgcc     2580

ttcatgcctg agttctacct aagtgtggct atcaacagct acagtgccct gaagaactat     2640

tttggccctg tgcacagcat ggaggaactc ccaggctatg aagagaccct gacacgctta     2700

gctgccatcc tcgccaaaca ctttgctgac cctcgaatag taggcactga tattcgagac     2760

tcactgatgc aggccctggc cagctatgtg tgctacccac actccctgcg ggctgtggaa     2820

cggattcctg aggaacagcg catcgccatg gtgaggaacc ttttggcacc ctatgagcaa     2880

cggccctggg cccagaccaa ctggatcctg gtgcggcttt ggaggggctg tgggtttggg     2940

taccgctata cacggctgcc acatctgctg aaaaccaagc cagaggatgc caatttgccc     3000

agcctccaaa agccctgccc ttcgaccttg ctacagcagc acatggcgga cctgctgcga     3060

caagggtctg atgtggcacc gagcttcctc aacagtgtcc ttaaccagct caactgggcc     3120

ttctctgagt tcatcggcat gatccaggag attcaacagg ctgctgaacg cctggagcgg     3180

aactttgtgg acagccgaca gctcaaggtc tgtgccacct gctttgacct gtcggtcagc     3240

ttgttgcgcg tcttggaaat gaccatcacg ctggtacctg aaatattcct tgactggtcc     3300

cgccctacct ctgagatgct gcttcggcgt ctggcacagc tgctgaacca ggtgctgaac     3360

cgggtgacag ctgagaggaa cctgtttgac cgtgtagtta ccctacggct acctgggctg     3420

gagagtgtgg accactaccc tatcctggtg gcagtgactg gcatcctggt acgcctcctg     3480

gtgcacggcc caacctcaga gacagagcaa gccacctctg tgctcctggc tgatccctgc     3540

ttccagcttc gttccatatg ctatctcctg gggcagccag agcccctagc acctggcact     3600

accttgcctg cccctgaccg gaaacgcttc tctctacaga gttatacaga ttatatcagc     3660

gctgaggagc tggcccaggt ggaacagatg ctggctcacc tgaccgctgc atctgcccag     3720

gcggccgccg cctccctgcc caccaatgaa gaggacctct gcccaatctg ctacgcccac     3780

cccatctctg ctgtgttcca gccttgtggt cacaaatcct gcaaagcctg catcaaccag     3840

cacctgatga acaacaagga ctgcttcttc tgcaaagcca ccattgtatc tgtagaggac     3900

tgggacaagg cagccaacac aagcgccatg tcctcagctg cctag                     3945


<210>  8
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequance

<400>  8
ccagaacatt tggaccagtt ggctacaggt ggacaatgag g                           41


<210>  9
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequance

<400>  9
gtgctgagtg atgccaggac acatcctgga agagaacatc c                           41


<210>  10
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequance


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Serine (S) can be altered by Proline (P)

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Serine (S) can be altered by Proline (P)

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  The Serine (S) may be phosphorylated

<400>  10

Asp Glu Leu Arg Asp Ser Asp Ser Val Cys Asp Ser Gly Val Glu Thr 
1               5                   10                  15      


Ser Phe Arg Lys Leu Ser Phe Thr Glu Ser 
            20                  25      


<210>  11
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequnnce

<400>  11
gcgcuacuau ugggaugaa                                                    19


<210>  12
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequance

<400>  12
caacugggcc uucucugaa                                                    19


<210>  13
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequance

<400>  13
gcacauggcg gaccuccua                                                    19


<210>  14
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequance

<400>  14
ggugaagcuu cuagguaua                                                    19


<210>  15
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequance

<400>  15
gcuaauugaa cacgcagaa                                                    19


<210>  16
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequance

<400>  16
gcacguaggu ggcguuguu                                                    19


<210>  17
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequance

<400>  17
cagaaugccg cgugcgagu                                                    19


<210>  18
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequance

<400>  18
agagaugagc ugacggaaa                                                    19


