                         SEQUENCE LISTING

<110>  IDD BIOTECH (INTERNATIONAL-DRUG-DEVELOPMENT BIOTECH)
 
<120>  ANTI-DR5 ANTIBODIES WITH ENHANCED APOPTOSIS POTENCY

<130>  BET14L2417

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hz031 VH

<400>  1
gaggtgcaac tgcagcaatc aggagcagaa gtcgtaaagc ccggtgcctc cgttaaactt       60

agctgcaaag caagtgggtt taatatcaaa gatacattca tccattgggt caaacaggca      120

ccaggccagg gccttgaatg gatcggtcgc atcgacccag ctaacggaaa cactaagtat      180

gaccctaagt tccagggaaa ggctacaatt acaacagata catcctccaa taccgcttac      240

atggagctgt cttccttgcg gtctgaggat actgctgtgt attactgtgt acgtgggctg      300

tacacatatt acttcgatta ttggggccag gggactcttg taaccgtttc ctcc            354


<210>  2
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz031 VH

<400>  2

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Phe Ile His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Thr Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Leu Tyr Thr Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  3
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hz031 VL

<400>  3
gagattgtta tgacacagtc ccctgctaca ttgagtgtta gtccaggcga aagagctaca       60

ctgtcatgta gggcctctca gtctattagc aataacctgc actggtatca gcaaaagcca      120

ggtcaagccc ccaggctgct gattaagttt gcatctcaaa gtattacagg aatccctgct      180

cggttcagcg gctccgggag tggaaccgag tttacactca caatctcaag cctccagtcc      240

gaagacttcg ccgtatatta ctgtcagcag ggcaactctt ggccctacac cttcggtcag      300

ggaaccaagc tggagatcaa g                                                321


<210>  4
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz031 VL

<400>  4

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Phe Ala Ser Gln Ser Ile Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Asn Ser Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  5
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hz033 VH

<400>  5
caagttcagt tggtacaatc aggtgcagaa gttaaaaagc caggggcatc tgttaaagtg       60

tcttgcaagg cctccggctt taatatcaag gacacacaca tgcattgggt gcgccaggcc      120

ccaggccagc gactggagtg gattgggcgt attgaccccg ccaacggcaa caccgagtat      180

gaccagaagt ttcagggccg tgtaaccatc accgtcgata cctcagcatc aaccgcttac      240

atggagcttt catctcttcg gtccgaagac acagccgtct attactgcgc tcgatgggga      300

acaaacgttt actttgcata ttggggtcag ggtactctcg tcaccgtgag cagt            354


<210>  6
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz033 VH

<400>  6

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


His Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Glu Tyr Asp Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Thr Asn Val Tyr Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  7
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hz033 VL

<400>  7
gatattcaac ttacacaatc tccctcttct ctctccgctt cagtagggga tagagtgacc       60

atcacttgct ctgcttcttc cagcgtgtca tatatgtatt ggtatcagca aaagcccggc      120

aaggcaccta aaccatggat ttacagaacc agcaatcttg ccagcggtgt tccaagtagg      180

tttagcggct ccggctctgg tacagacttt accctgacta tctcctctct ccagcccgag      240

gattttgcca catattactg ccagcaatac cattcttacc ctccaacttt tggaggtggc      300

actaaggtgg agatcaag                                                    318


<210>  8
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hz033 VL

<400>  8

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  9
<211>  993
<212>  DNA
<213>  Homo sapiens

<400>  9
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtcgtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tag                                   993


<210>  10
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  10

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  11
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  11
cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg ttag                                             324


<210>  12
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  12

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  13
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  13

Gly Phe Asn Ile Lys Asp Thr Phe 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  14

Ile Asp Pro Ala Asn Gly Asn Thr 
1               5               


<210>  15
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  15

Val Arg Gly Leu Tyr Thr Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210>  16
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  16

Gln Ser Ile Ser Asn Asn 
1               5       


<210>  17
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  17

Gln Gln Gly Asn Ser Trp Pro Tyr Thr 
1               5                   


<210>  18
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  18

Gly Phe Asn Ile Lys Asp Thr His 
1               5               


<210>  19
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  19

Ala Arg Trp Gly Thr Asn Val Tyr Phe Ala Tyr 
1               5                   10      


<210>  20
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  20

Ser Ser Val Ser Tyr 
1               5   


<210>  21
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  21

Gln Gln Tyr His Ser Tyr Pro Pro Thr 
1               5                   


<210>  22
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  22

Asp Thr Phe Ile His 
1               5   


<210>  23
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  23

Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  24
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  24

Gly Leu Tyr Thr Tyr Tyr Phe Asp Tyr 
1               5                   


<210>  25
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  25

Arg Ala Ser Gln Ser Ile Ser Asn Asn Leu His 
1               5                   10      


<210>  26
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  26

Phe Ala Ser Gln Ser Ile Thr 
1               5           


<210>  27
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  27

Asp Thr His Ile His 
1               5   


<210>  28
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  28

Arg Ile Asp Pro Ala Asn Gly Asn Thr Glu Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  29
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  29

Trp Gly Thr Asn Val Tyr Phe Ala Tyr 
1               5                   


<210>  30
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  30

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  31
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  31

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  32
<211>  4
<212>  PRT
<213>  Mus musculus

<400>  32

Lys Asp Thr Phe 
1               


<210>  33
<211>  4
<212>  PRT
<213>  Mus musculus

<400>  33

Lys Asp Thr His 
1               


