                         SEQUENCE LISTING

<110>  Universiteit Gent
 
<120>  Production of specific glucosides with cellobiose phosphorylase

<130>  P2014/064PCT

<150>  EP15152108.5
<151>  2015-01-22

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  811
<212>  PRT
<213>  Clostridium thermocellum

<400>  1

Met Lys Phe Gly Phe Phe Asp Asp Ala Asn Lys Glu Tyr Val Ile Thr 
1               5                   10                  15      


Val Pro Arg Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Thr Glu Asn 
            20                  25                  30          


Phe Phe Ser Leu Ile Ser Asn Thr Ala Gly Gly Tyr Cys Phe Tyr Arg 
        35                  40                  45              


Asp Ala Arg Leu Arg Arg Ile Thr Arg Tyr Arg Tyr Asn Asn Val Pro 
    50                  55                  60                  


Ile Asp Met Gly Gly Arg Tyr Phe Tyr Ile Tyr Asp Asn Gly Asp Phe 
65                  70                  75                  80  


Trp Ser Pro Gly Trp Ser Pro Val Lys Arg Glu Leu Glu Ser Tyr Glu 
                85                  90                  95      


Cys Arg His Gly Leu Gly Tyr Thr Lys Ile Ala Gly Lys Arg Asn Gly 
            100                 105                 110         


Ile Lys Ala Glu Val Thr Phe Phe Val Pro Leu Asn Tyr Asn Gly Glu 
        115                 120                 125             


Val Gln Lys Leu Ile Leu Lys Asn Glu Gly Gln Asp Lys Lys Lys Ile 
    130                 135                 140                 


Thr Leu Phe Ser Phe Ile Glu Phe Cys Leu Trp Asn Ala Tyr Asp Asp 
145                 150                 155                 160 


Met Thr Asn Phe Gln Arg Asn Phe Ser Thr Gly Glu Val Glu Ile Glu 
                165                 170                 175     


Gly Ser Val Ile Tyr His Lys Thr Glu Tyr Arg Glu Arg Arg Asn His 
            180                 185                 190         


Tyr Ala Phe Tyr Ser Val Asn Ala Lys Ile Ser Gly Phe Asp Ser Asp 
        195                 200                 205             


Arg Asp Ser Phe Ile Gly Leu Tyr Asn Gly Phe Asp Ala Pro Gln Ala 
    210                 215                 220                 


Val Val Asn Gly Lys Ser Asn Asn Ser Val Ala Asp Gly Trp Ala Pro 
225                 230                 235                 240 


Ile Ala Ser His Ser Ile Glu Ile Glu Leu Asn Pro Gly Glu Gln Lys 
                245                 250                 255     


Glu Tyr Val Phe Ile Ile Gly Tyr Val Glu Asn Lys Asp Glu Glu Lys 
            260                 265                 270         


Trp Glu Ser Lys Gly Val Ile Asn Lys Lys Lys Ala Tyr Glu Met Ile 
        275                 280                 285             


Glu Gln Phe Asn Thr Val Glu Lys Val Asp Lys Ala Phe Glu Glu Leu 
    290                 295                 300                 


Lys Ser Tyr Trp Asn Ala Leu Leu Ser Lys Tyr Phe Leu Glu Ser His 
305                 310                 315                 320 


Asp Glu Lys Leu Asn Arg Met Val Asn Ile Trp Asn Gln Tyr Gln Cys 
                325                 330                 335     


Met Val Thr Phe Asn Met Ser Arg Ser Ala Ser Tyr Phe Glu Ser Gly 
            340                 345                 350         


Ile Gly Arg Gly Met Gly Phe Arg Asp Ser Asn Gln Asp Leu Leu Gly 
        355                 360                 365             


Phe Val His Gln Ile Pro Glu Arg Ala Arg Glu Arg Leu Leu Asp Leu 
    370                 375                 380                 


Ala Ala Thr Gln Leu Glu Asp Gly Ser Ala Tyr His Gln Tyr Gln Pro 
385                 390                 395                 400 


Leu Thr Lys Lys Gly Asn Asn Glu Ile Gly Ser Asn Phe Asn Asp Asp 
                405                 410                 415     


Pro Leu Trp Leu Ile Leu Ala Thr Ala Ala Tyr Ile Lys Glu Thr Gly 
            420                 425                 430         


Asp Tyr Ser Ile Leu Lys Glu Gln Val Pro Phe Asn Asn Asp Pro Ser 
        435                 440                 445             


Lys Ala Asp Thr Met Phe Glu His Leu Thr Arg Ser Phe Tyr His Val 
    450                 455                 460                 


Val Asn Asn Leu Gly Pro His Gly Leu Pro Leu Ile Gly Arg Ala Asp 
465                 470                 475                 480 


Trp Asn Asp Cys Leu Asn Leu Asn Cys Phe Ser Thr Val Pro Asp Glu 
                485                 490                 495     


Ser Phe Gln Thr Thr Thr Ser Lys Asp Gly Lys Val Ala Glu Ser Val 
            500                 505                 510         


Met Ile Ala Gly Met Phe Val Phe Ile Gly Lys Asp Tyr Val Lys Leu 
        515                 520                 525             


Cys Glu Tyr Met Gly Leu Glu Glu Glu Ala Arg Lys Ala Gln Gln His 
    530                 535                 540                 


Ile Asp Ala Met Lys Glu Ala Ile Leu Lys Tyr Gly Tyr Asp Gly Glu 
545                 550                 555                 560 


Trp Phe Leu Arg Ala Tyr Asp Asp Phe Gly Arg Lys Val Gly Ser Lys 
                565                 570                 575     


Glu Asn Glu Glu Gly Lys Ile Phe Ile Glu Ser Gln Gly Phe Cys Val 
            580                 585                 590         


Met Ala Glu Ile Gly Leu Glu Asp Gly Lys Ala Leu Lys Ala Leu Asp 
        595                 600                 605             


Ser Val Lys Lys Tyr Leu Asp Thr Pro Tyr Gly Leu Val Leu Gln Asn 
    610                 615                 620                 


Pro Ala Phe Thr Arg Tyr Tyr Ile Glu Tyr Gly Glu Ile Ser Thr Tyr 
625                 630                 635                 640 


Pro Pro Gly Tyr Lys Glu Asn Ala Gly Ile Phe Cys His Asn Asn Ala 
                645                 650                 655     


Trp Ile Ile Cys Ala Glu Thr Val Val Gly Arg Gly Asp Met Ala Phe 
            660                 665                 670         


Asp Tyr Tyr Arg Lys Ile Ala Pro Ala Tyr Ile Glu Asp Val Ser Asp 
        675                 680                 685             


Ile His Lys Leu Glu Pro Tyr Val Tyr Ala Gln Met Val Ala Gly Lys 
    690                 695                 700                 


Asp Ala Lys Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr 
705                 710                 715                 720 


Ala Ala Trp Asn Phe Val Ala Ile Ser Gln Trp Ile Leu Gly Val Lys 
                725                 730                 735     


Pro Asp Tyr Asp Gly Leu Lys Ile Asp Pro Cys Ile Pro Lys Ala Trp 
            740                 745                 750         


Asp Gly Tyr Lys Val Thr Arg Tyr Phe Arg Gly Ser Thr Tyr Glu Ile 
        755                 760                 765             


Thr Val Lys Asn Pro Asn His Val Ser Lys Gly Val Ala Lys Ile Thr 
    770                 775                 780                 


Val Asp Gly Asn Glu Ile Ser Gly Asn Ile Leu Pro Val Phe Asn Asp 
785                 790                 795                 800 


Gly Lys Thr His Lys Val Glu Val Ile Met Gly 
                805                 810     


<210>  2
<211>  822
<212>  PRT
<213>  Cellvibrio gilvus

<400>  2

Met Arg Tyr Gly His Phe Asp Asp Ala Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Arg Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Leu Lys Val Glu Thr Leu Phe Phe Val Pro Leu Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ala Pro Lys Thr Ala 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Gln Thr Asn Tyr Gln Arg Asn Leu Ser Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Asp Gly Pro His Gly Ser Ala Ile Tyr His Lys Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asp His Tyr Ala Val Phe Gly Val Asn Thr Arg Ala Asp 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Ala Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ser Val Pro Arg Ala Gly Lys Ser Ala Asp Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Thr Leu Gln 
                245                 250                 255     


Pro Gly Glu Ser Arg Asp Leu Val Tyr Val Leu Gly Tyr Leu Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala His Gln Val Val Asn Lys 
        275                 280                 285             


Ala Pro Ala His Ala Leu Leu Gly Arg Phe Ala Thr Ser Glu Gln Val 
    290                 295                 300                 


Asp Ala Ala Leu Glu Ala Leu Asn Ser Tyr Trp Thr Asn Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Thr Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Val Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Ser Gly Asp Trp Gly Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Gln Phe Thr Val Gln Asn Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Ala 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Val Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Ala Glu Tyr Ala Thr Leu Ala Glu Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Thr Glu Ala Arg Lys Tyr Val Asp Glu Val Arg Ala Ala Val Leu 
545                 550                 555                 560 


Glu His Gly Trp Asp Gly Gln Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Val Gly Thr Asp Ala Lys Pro Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Ile Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Asp Asp Ala Asp Ala Pro Ala Val Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Gly Thr Pro His Gly Leu Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Ile Glu Leu Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Ala Gln Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Thr His Lys 
    690                 695                 700                 


Leu Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg Ala Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Ala Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Asp Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Tyr 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Ala Pro Gly Ala Arg Ala Ser Leu Thr Val Asp Gly Ala 
785                 790                 795                 800 


Pro Val Asp Gly Arg Thr Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Glu Val Thr Val 
            820         


<210>  3
<211>  822
<212>  PRT
<213>  Cellulomonas uda

<400>  3

Met Arg Tyr Gly His Phe Asp Asp Glu Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro His Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Ser Glu Gln 
            20                  25                  30          


Phe Phe Ser Leu Leu Ser His Gln Ala Gly Gly Tyr Ser Phe Tyr Arg 
        35                  40                  45              


Asp Ala Lys Met Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Ile Pro 
    50                  55                  60                  


Ala Asp Ala Gly Gly Arg Tyr Leu Tyr Val Asn Asp Gly Gly Asp Val 
65                  70                  75                  80  


Trp Thr Pro Ser Trp Leu Pro Val Lys Ala Asp Leu Asp His Phe Glu 
                85                  90                  95      


Ala Arg His Gly Leu Gly Tyr Ser Thr Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Arg Val Glu Thr Leu Phe Phe Val Pro Val Gly Glu Asn Ala Glu 
        115                 120                 125             


Val Gln Lys Val Thr Val Thr Asn Thr Ser Asp Ser Tyr Lys Ser Leu 
    130                 135                 140                 


Thr Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Gln Asp Asp 
145                 150                 155                 160 


Gln Thr Asn Tyr Gln Arg Asn Leu Ser Ile Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gln Glu Ser Pro His Gly Ser Ala Ile Tyr His Arg Thr Glu Tyr Arg 
            180                 185                 190         


Glu Arg Arg Asp His Tyr Ala Val Phe Ala Val Asn Thr Gln Ala Glu 
        195                 200                 205             


Gly Phe Asp Thr Asp Arg Asp Thr Phe Val Gly Ala Tyr Asn Ser Leu 
    210                 215                 220                 


Gly Glu Ala Ala Val Pro Leu Lys Gly Glu Ser Ala Asn Ser Val Ala 
225                 230                 235                 240 


Ser Gly Trp Tyr Pro Ile Gly Ser His Ser Val Ala Val Ser Leu Ala 
                245                 250                 255     


Pro Gly Glu Ser Arg Glu Leu Val Tyr Val Leu Gly Tyr Val Glu Asn 
            260                 265                 270         


Pro Asp Glu Glu Lys Trp Ala Asp Asp Ala Lys Gln Val Val Asn Lys 
        275                 280                 285             


Glu Arg Ala His Ala Leu Leu Ser Arg Phe Ala Thr Ser Glu Gln Thr 
    290                 295                 300                 


Asp Ala Ala Phe Ala Ala Leu Lys Asp Tyr Trp Thr Asp Leu Leu Ser 
305                 310                 315                 320 


Thr Tyr Ser Val Ser Ser Asn Asp Glu Lys Leu Asp Arg Met Val Asn 
                325                 330                 335     


Ile Trp Asn Gln Tyr Gln Cys Met Val Thr Phe Asn Met Ser Arg Ser 
            340                 345                 350         


Ala Ser Phe Phe Glu Thr Gly Ile Gly Arg Gly Met Gly Phe Arg Asp 
        355                 360                 365             


Ser Asn Gln Asp Leu Leu Gly Phe Val His Leu Ile Pro Glu Arg Ala 
    370                 375                 380                 


Arg Glu Arg Ile Ile Asp Ile Ala Ser Thr Gln Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Ala Tyr His Gln Tyr Gln Pro Leu Thr Lys Arg Gly Asn Asn Asp Ile 
                405                 410                 415     


Gly Ser Gly Phe Asn Asp Asp Pro Leu Trp Leu Ile Ala Gly Thr Ala 
            420                 425                 430         


Ala Tyr Ile Lys Glu Thr Gly Asp Phe Ser Ile Leu Asp Glu Pro Val 
        435                 440                 445             


Pro Phe Asp Asn Glu Pro Gly Ser Glu Val Pro Leu Phe Glu His Leu 
    450                 455                 460                 


Thr Arg Ser Phe Glu Phe Thr Val Thr His Arg Gly Pro His Gly Leu 
465                 470                 475                 480 


Pro Leu Ile Gly Arg Ala Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys 
                485                 490                 495     


Phe Ser Thr Thr Pro Gly Glu Ser Phe Gln Thr Thr Glu Asn Gln Ala 
            500                 505                 510         


Gly Gly Val Ala Glu Ser Thr Phe Ile Ala Ala Gln Phe Val Leu Tyr 
        515                 520                 525             


Gly Glu Gln Tyr Ala Glu Leu Ala Ala Arg Arg Gly Leu Ala Asp Val 
    530                 535                 540                 


Ala Asp Arg Ala Arg Gly His Val Ala Glu Met Arg Asp Ala Leu Leu 
545                 550                 555                 560 


Thr Asp Gly Trp Asp Gly Ser Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr 
                565                 570                 575     


Gly Asn Pro Ile Gly Thr Asp Ala His Asp Glu Gly Lys Ile Trp Ile 
            580                 585                 590         


Glu Pro Gln Gly Phe Ala Val Met Ala Gly Val Gly Val Gly Glu Gly 
        595                 600                 605             


Pro Gln Asp Thr Asp Ala Pro Ala Ile Lys Ala Leu Asp Ser Val Asn 
    610                 615                 620                 


Glu Met Leu Ala Thr Asp His Gly Met Val Leu Gln Tyr Pro Ala Tyr 
625                 630                 635                 640 


Thr Thr Tyr Gln Val His Met Gly Glu Val Ser Thr Tyr Pro Pro Gly 
                645                 650                 655     


Tyr Lys Glu Asn Gly Gly Ile Phe Cys His Asn Asn Pro Trp Val Ile 
            660                 665                 670         


Ile Ala Glu Thr Val Val Gly Arg Gly Gly Arg Ala Phe Asp Tyr Tyr 
        675                 680                 685             


Lys Arg Ile Thr Pro Ala Tyr Arg Glu Asp Ile Ser Asp Val His Arg 
    690                 695                 700                 


Leu Glu Pro Tyr Val Tyr Ala Gln Met Ile Ala Gly Lys Glu Ala Val 
705                 710                 715                 720 


Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr Ala Ala Trp 
                725                 730                 735     


Asn Phe Val Thr Val Ser Gln Tyr Leu Leu Gly Val Arg Pro Glu Tyr 
            740                 745                 750         


Asp Gly Leu Val Val Asp Pro Gln Ile Gly Pro Asp Val Pro Ser Phe 
        755                 760                 765             


Thr Val Thr Arg Val Ala Arg Gly Ala Thr Tyr Glu Ile Thr Val Thr 
    770                 775                 780                 


Asn Ser Gly Thr Asp Gly Ser Arg Gly Arg Leu Val Val Asp Gly Thr 
785                 790                 795                 800 


Pro Val Glu Gly Asn Leu Val Pro Tyr Ala Pro Ala Gly Ser Thr Val 
                805                 810                 815     


Arg Val Asp Val Thr Leu 
            820         


<210>  4
<211>  780
<212>  PRT
<213>  Clostridium stercorarium

<400>  4

Met Arg Tyr Gly Tyr Phe Asp Glu Lys Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Arg Pro Asp Thr Pro Thr Pro Trp Ile Asn Tyr Ile Gly Asn Gly Lys 
            20                  25                  30          


Tyr Gly Gly Ile Val Thr Asn Thr Gly Gly Gly Tyr Ser Phe His Lys 
        35                  40                  45              


Asp Pro Gln Asn Arg Arg Ile Thr Arg Tyr Arg Tyr Asn Asn Leu Pro 
    50                  55                  60                  


Thr Asp Arg Pro Gly Arg Tyr Ile Tyr Val Arg Asp Arg Leu Thr Gly 
65                  70                  75                  80  


Glu Tyr Trp Asn Pro Gly Tyr Gln Pro Val Gln Arg Lys Leu Asp Ser 
                85                  90                  95      


Tyr Arg Cys Arg His Gly Met Gly Tyr Thr Val Leu Glu Gly Glu Tyr 
            100                 105                 110         


Lys Gly Ile Ala Ala Asp Val Thr Tyr Phe Val Pro Asp Asp Arg Asp 
        115                 120                 125             


Phe Glu Ile Trp Leu Val Gln Ile Arg Asn Leu Cys His Val Glu Arg 
    130                 135                 140                 


Asn Leu Gln Val Phe Ser Tyr Ala Glu Phe Cys Phe Trp Asp Ala Ile 
145                 150                 155                 160 


Met Asp Gln Gln Asn Val Asp Trp Val Gln Gln Ile Asn Gln Gly Arg 
                165                 170                 175     


Tyr Glu Asp Arg Leu Ile Thr Trp His Pro His His Phe Lys Asp Ala 
            180                 185                 190         


Cys Ala Phe Phe Ala Thr Asn Ala Glu Ile Asn Ser Phe Asp Thr Asn 
        195                 200                 205             


Leu Glu Ala Phe Ile Gly Arg Tyr Arg Cys Glu Ser Asn Pro Ile Ala 
    210                 215                 220                 


Val Glu Thr Gly Ala Cys Ser Asn Ser Val Ser Tyr Arg Met Asn Gly 
225                 230                 235                 240 


Val Gly Ala Phe Cys Ile Asp Val Asn Leu Lys Pro Gly Glu Glu Arg 
                245                 250                 255     


Glu Ile Ile Phe Ile Leu Gly Phe Thr Glu Asn Lys Ser Thr Ile Arg 
            260                 265                 270         


Asp Glu Ile Arg Asp Tyr Leu Asn Val Glu Tyr Ala Lys Glu Ala Leu 
        275                 280                 285             


Lys Arg Leu Lys Asp Ser Trp Glu Glu Tyr Leu Asp Lys Leu Gln Ile 
    290                 295                 300                 


Glu Thr Pro Asp Arg Glu Thr Asn Leu Phe Val Asn Thr Trp Asn Gln 
305                 310                 315                 320 


Tyr Gln Cys Lys Ile Thr Phe Asn Trp Ser Arg Phe Val Ser Met Tyr 
                325                 330                 335     


Ser Trp Gly Leu Gly Arg Gly Ile Gly Ile Arg Asp Ser Ala Gln Asp 
            340                 345                 350         


Thr Leu Gly Val Met His Ser Ile Pro Glu Leu Ala Gly Gly Leu Ile 
        355                 360                 365             


Lys Arg Leu Ile His Cys Gln Tyr Thr Asp Gly Arg Val Tyr His Leu 
    370                 375                 380                 


Phe Phe Pro Leu Thr Gly Glu Gly Gly Ile Gly Asp Ala Pro Val Val 
385                 390                 395                 400 


Lys Phe Asp Trp Tyr Ser Asp Asp His Leu Trp Leu Pro Ile Ala Ala 
                405                 410                 415     


Asn Ala Tyr Leu Lys Glu Thr Ala Asn Phe Asp Phe Phe Gln Ser Val 
            420                 425                 430         


Val Pro Tyr Asn Asp Asn Lys Thr Glu Gly Thr Val Trp Glu His Leu 
        435                 440                 445             


Asn Arg Ala Met Glu Phe Thr Tyr Asn His Arg Gly Pro His Ala Leu 
    450                 455                 460                 


Pro Tyr Ser Arg Ala Asp Trp Asn Asp Thr Leu Asn Leu Asp Met Gly 
465                 470                 475                 480 


Asn Gly Ile Ala Glu Thr Leu Phe Thr Ser Met Leu Phe Ser Glu Pro 
                485                 490                 495     


Pro Leu Lys Arg Phe Arg Cys Arg Ile Ser Asp Lys Arg Ile Ala Thr 
            500                 505                 510         


Lys Tyr Arg Tyr Trp Tyr Asp Glu Met Lys Gln Ala Ile Asn Glu Trp 
        515                 520                 525             


Cys Trp Asp Gly Glu Trp Tyr Ile Arg Ala Phe Asp Asp Glu Gly Asn 
    530                 535                 540                 


Val Leu Gly Ser Gly Lys Asn Arg Tyr Gly Lys Ile Phe Ile Asn Ser 
545                 550                 555                 560 


Gln Ser Trp Ala Val Leu Ser Met Val Ala Pro Glu Glu Tyr Ala Lys 
                565                 570                 575     


Lys Cys Leu Glu Ser Val Tyr Arg His Leu Asn Thr Lys Tyr Gly Ile 
            580                 585                 590         


Val Lys Val Tyr Pro Ala Tyr Pro Glu Tyr Asn Pro Lys Ile Gly Gly 
        595                 600                 605             


Met Thr Thr Tyr Pro Pro Gly Ala Lys Glu Asn Gly Gly Ile Phe Ala 
    610                 615                 620                 


His Thr Asn Pro Trp Val Met Ile Ala Glu Cys Met Met Gly Asn Gly 
625                 630                 635                 640 


Arg Arg Ala Tyr Gln Tyr Tyr Arg Gln Ile Leu Pro Leu Thr Arg Asn 
                645                 650                 655     


Asp Asp Ala Asp Leu Leu Glu Val Glu Pro Tyr Val Tyr Cys Gln Asn 
            660                 665                 670         


Ile Leu Gly Lys Glu His Pro Gln Phe Gly Ile Gly Arg Asn Ser Trp 
        675                 680                 685             


Leu Thr Gly Thr Ala Ala Trp Asn Met Val Ala Val Ser Gln Tyr Ile 
    690                 695                 700                 


Leu Gly Ile Arg Pro Glu Tyr Asp Gly Leu Thr Val Asp Pro Cys Ile 
705                 710                 715                 720 


Pro Pro Asp Trp Lys Gly Phe Lys Val Arg Arg Ile Phe Arg Gly Cys 
                725                 730                 735     


Val Tyr Asn Ile Glu Val Arg Asn Pro Glu Gly Val Arg Arg Cys Glu 
            740                 745                 750         


Lys Asn Cys Arg Arg Gly Val Glu Thr Asp Lys Ile Pro Val Lys Pro 
        755                 760                 765             


Ala Gly Thr Val Cys Glu Cys Val Val Ile Met Gly 
    770                 775                 780 


<210>  5
<211>  2436
<212>  DNA
<213>  Artificial sequence

<220>
<223>  codon optimized sequence from Clostridium thermocellum YM4

<400>  5
atgaaatttg gcttttttga tgatgccaat aaagaatatg tgattaccgt tccgcgtacc       60

ccgtatccgt ggattaatta tctgggcacc gaaaattttt ttagcctgat tagcaatacc      120

gcaggcggtt attgttttta tcgtgatgca cgtctgcgtc gtattacccg ttatcgttat      180

aataatgtgc cgattgatat gggtggtcgc tatttttata tttatgataa tggcgatttt      240

tggagtccgg gttggagtcc ggttaaacgt gaactggaaa gctatgaatg tcgtcatggt      300

ctgggctata ccaaaattgc aggtaaacgc aatggcatta aagccgaagt tacctttttt      360

gtgccgctga attataacgg cgaagtgcag aaactgattc tgaaaaatga aggccaggat      420

aaaaaaaaaa ttaccctgtt tagctttatt gaattttgcc tgtggaatgc ctatgatgat      480

atgaccaatt ttcagcgcaa ttttagcacc ggtgaagttg aaattgaagg cagcgtgatt      540

tatcataaaa ccgaatatcg cgaacgtcgc aatcattatg ccttttatag cgtgaatgcc      600

aaaatttcag gctttgatag cgatcgcgat agctttattg gtctgtataa tggttttgat      660

gcaccgcagg cagttgttaa tggcaaaagc aataatagcg ttgcagatgg ttgggcaccg      720

attgcaagcc atagcattga aattgaactg aatccgggtg aacagaaaga atatgttttt      780

attattggct atgtggaaaa taaagatgaa gaaaaatggg aaagcaaagg cgtgattaat      840

aaaaaaaaag cctatgaaat gattgaacag tttaataccg tggaaaaagt ggataaagcc      900

tttgaagaac tgaaaagcta ttggaatgcc ctgctgagca aatattttct ggaaagccat      960

gatgaaaaac tgaatcgcat ggtgaatatt tggaatcagt atcagtgcat ggtgaccttt     1020

aatatgagcc gtagcgcaag ctattttgaa agcggtattg gtcgtggtat gggttttcgt     1080

gatagcaatc aggatctgct gggttttgtt catcagattc cggaacgtgc acgtgaacgt     1140

ctgctggatc tggcagcaac ccagctggaa gatggtagcg catatcatca gtatcagccg     1200

ctgaccaaaa aaggcaataa tgaaattggc agcaatttta atgatgatcc gctgtggctg     1260

attctggcaa ccgcagcata tattaaagaa accggtgatt atagcattct gaaagaacag     1320

gtgccgttta ataatgatcc gagcaaagca gataccatgt ttgaacatct gacccgtagc     1380

ttttatcatg tggttaataa tctgggtccg catggtctgc cgctgattgg tcgtgcagat     1440

tggaatgatt gtctgaatct gaattgcttt agcaccgttc cggatgaaag ctttcagacc     1500

accaccagta aagatggtaa agttgcagaa agcgttatga ttgccggtat gtttgtgttt     1560

attggcaaag attatgtgaa actgtgcgaa tatatgggcc tggaagaaga agcacgtaaa     1620

gcacagcagc atattgatgc aatgaaagaa gccattctga aatacggcta tgatggtgaa     1680

tggtttctgc gtgcatatga tgattttggt cgtaaagtgg gcagcaaaga aaatgaagaa     1740

ggcaaaattt ttattgaaag ccagggcttt tgcgtgatgg cagaaattgg tctggaagat     1800

ggcaaagcac tgaaagccct ggatagcgtt aaaaaatatc tggatacccc gtatggtctg     1860

gttctgcaga atccggcatt tacccgttat tatattgaat atggcgaaat ttccacctat     1920

ccgccgggtt ataaagaaaa tgccggtatt ttttgccata ataatgcctg gattatttgt     1980

gccgaaaccg ttgttggtcg tggtgatatg gcctttgatt attatcgtaa aattgcaccg     2040

gcatatattg aagatgtgag cgatattcat aaactggaac cgtatgttta tgcacagatg     2100

gttgcaggta aagatgcaaa acgtcatggt gaagcaaaaa atagctggct gaccggcacc     2160

gcagcatgga attttgttgc aattagccag tggattctgg gtgttaaacc ggattatgat     2220

ggcctgaaaa ttgatccgtg tattccgaaa gcatgggatg gttataaagt gacccgttat     2280

tttcgtggta gcacctatga aatcaccgtg aaaaatccga atcatgtgag caaaggtgtg     2340

gcaaaaatta ccgttgatgg caatgaaatt agcggtaata ttctgccggt gtttaatgat     2400

ggcaaaaccc ataaagtgga agtgattatg ggttaa                               2436


<210>  6
<211>  811
<212>  PRT
<213>  Clostridium stercorarium

<400>  6

Met Lys Phe Gly Tyr Phe Asp Asp Val Asn Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro Ala Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Cys Gln Asp 
            20                  25                  30          


Phe Phe Ser Leu Ile Ser Asn Thr Ser Gly Gly Tyr Cys Phe Tyr Arg 
        35                  40                  45              


Asp Ala Arg Leu Arg Arg Ile Thr Arg Tyr Arg Tyr Asn Asn Val Pro 
    50                  55                  60                  


Ile Asp Ser Gly Gly Arg Tyr Phe Tyr Ile Tyr Asp Ser Gly Asp Tyr 
65                  70                  75                  80  


Trp Thr Pro Gly Trp Met Pro Val Lys Arg Glu Leu Asp Arg Tyr Glu 
                85                  90                  95      


Cys Arg His Gly Leu Gly Tyr Thr Arg Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Val Glu Val Ser Gln Leu Ala Phe Val Pro Leu Asn Tyr Asn Gly Glu 
        115                 120                 125             


Val Asn Gln Val Val Ile Thr Asn Lys Ser Gly Ser Glu Lys Glu Ile 
    130                 135                 140                 


Ala Leu Phe Ser Phe Val Glu Phe Cys Leu Trp Asn Ala Met Asp Asp 
145                 150                 155                 160 


Met Thr Asn Phe Gln Arg Asn Phe Ser Thr Gly Glu Val Glu Val Glu 
                165                 170                 175     


Gly Ser Ala Ile Tyr His Lys Thr Glu Tyr Arg Glu Arg Arg Asn His 
            180                 185                 190         


Tyr Ala Phe Phe Trp Val Asn Ser Pro Ile Asp Gly Phe Asp Thr Asp 
        195                 200                 205             


Arg Glu Ser Phe Leu Gly Leu Tyr Asn Gly Phe Asp Ser Pro Lys Asn 
    210                 215                 220                 


Val Ala Ala Gly Lys Pro Thr Asn Ser Ile Ala Ser Gly Trp Ser Pro 
225                 230                 235                 240 


Ile Ala Ser His Tyr Ile Lys Met Ser Leu Lys Pro Gly Glu Lys Arg 
                245                 250                 255     


Ser Tyr Ile Phe Val Leu Gly Tyr Val Glu Asn Pro Pro Glu Glu Lys 
            260                 265                 270         


Trp Glu Arg Lys Gly Val Ile Asn Lys Lys Arg Ala Arg Glu Met Gln 
        275                 280                 285             


Gln Lys Phe Ile Asp Asp Thr Cys Val Glu Lys Ala Phe Gln Glu Leu 
    290                 295                 300                 


Lys Asp Tyr Trp Ala Asp Leu Cys Ser Lys Phe Ala Leu Glu Ser His 
305                 310                 315                 320 


Asp Glu Lys Leu Asn Arg Met Val Asn Ile Trp Asn Pro Tyr Gln Cys 
                325                 330                 335     


Met Val Thr Phe Asn Met Ser Arg Ser Ala Ser Tyr Phe Glu Ser Gly 
            340                 345                 350         


Ile Ser Arg Gly Met Gly Phe Arg Asp Ser Ala Gln Asp Leu Leu Gly 
        355                 360                 365             


Phe Val His Gln Val Pro Glu Arg Ala Arg Gln Arg Ile Leu Asp Leu 
    370                 375                 380                 


Ala Ser Thr Gln Phe Glu Asp Gly Ser Ala Tyr His Gln Tyr Gln Pro 
385                 390                 395                 400 


Leu Thr Lys Lys Gly Asn Ser Asp Ile Gly Ser Gly Phe Asn Asp Asp 
                405                 410                 415     


Pro Leu Trp Leu Ile Leu Ala Thr Ala Gln Tyr Ile Lys Glu Thr Gly 
            420                 425                 430         


Asp Phe Gly Ile Leu Asp Glu Met Val Pro Phe Asp Cys Asp Glu Asn 
        435                 440                 445             


Lys Lys Asp Thr Leu Phe Glu His Leu Lys Arg Ser Phe Tyr His Val 
    450                 455                 460                 


Val Asn Asn Leu Gly Pro His Gly Leu Pro Leu Ile Gly Arg Ala Asp 
465                 470                 475                 480 


Trp Asn Asp Cys Leu Asn Leu Asn Cys Phe Ser Thr Gln Pro Met Asn 
                485                 490                 495     


Pro Phe Thr Pro Ala Asp Lys Phe Glu Gly Arg Val Ala Glu Ser Val 
            500                 505                 510         


Phe Ile Ala Gly Met Phe Val Leu Ile Gly Pro Glu Tyr Val Glu Leu 
        515                 520                 525             


Cys Lys Arg Arg Gly Leu Ser Glu Glu Ala Ala Glu Ala Glu Lys His 
    530                 535                 540                 


Ile Gln Asn Met Val Asn Ala Val Leu Thr His Gly Tyr Asp Gly Glu 
545                 550                 555                 560 


Trp Phe Leu Arg Ala Tyr Asp His Phe Gly Asn Lys Ile Gly Ser Lys 
                565                 570                 575     


Glu Cys Ser Glu Gly Gln Ile Phe Ile Glu Pro Gln Gly Ile Cys Val 
            580                 585                 590         


Met Ala Gly Ile Gly Val Lys Glu Gly Leu Ala Gln Lys Ala Leu Asp 
        595                 600                 605             


Ser Val Met Lys Arg Leu Asp Thr Lys Tyr Gly Ile Val Leu His Thr 
    610                 615                 620                 


Pro Ala Tyr Thr Glu Tyr Tyr Leu Asn Leu Gly Glu Ile Ser Ser Tyr 
625                 630                 635                 640 


Pro Pro Gly Tyr Lys Glu Asn Ala Gly Ile Phe Cys His Asn Asn Pro 
                645                 650                 655     


Trp Ile Ala Ile Ala Glu Thr Val Ile Gly Arg Gly Asp Arg Ala Phe 
            660                 665                 670         


Glu Val Tyr Ser Lys Ile Ala Pro Ala Tyr Ile Glu Asp Ile Ser Asp 
        675                 680                 685             


Ile His Arg Thr Glu Pro Tyr Val Tyr Ser Gln Met Ile Ala Gly Arg 
    690                 695                 700                 


Thr Arg Trp Ser Phe Gly Glu Ala Lys Asn Ser Trp Leu Thr Gly Thr 
705                 710                 715                 720 


Ala Ala Trp Asn Phe Val Ala Ile Thr Gln Tyr Ile Leu Gly Val Arg 
                725                 730                 735     


Pro Val Tyr Asp Gly Leu Met Val Asp Pro Cys Ile Pro Ala Ser Trp 
            740                 745                 750         


Asp Gly Phe Thr Val Thr Arg Glu Phe Arg Gly Ser Lys Tyr Arg Ile 
        755                 760                 765             


Arg Val Glu Asn Pro Glu His Ile Cys Lys Gly Val Asn Lys Val Ile 
    770                 775                 780                 


Met Asp Gly Lys Glu Ile Glu Gly Gln Val Leu Pro Val Ser Pro Lys 
785                 790                 795                 800 


Glu Ser Glu His Glu Val Ile Val Ile Met Gly 
                805                 810     


<210>  7
<211>  811
<212>  PRT
<213>  Saccharophagus degradans

<400>  7

Met Lys Phe Gly His Phe Asp Asp Lys Ala Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Asp Pro Lys Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Asn Glu Asp 
            20                  25                  30          


Phe Phe Ser Leu Val Ser Asn Thr Gly Gly Gly Tyr Ser Phe Tyr Lys 
        35                  40                  45              


Asp Ala Lys Phe Arg Arg Leu Thr Arg Tyr Arg Tyr Asn Asn Val Pro 
    50                  55                  60                  


Val Asp Asn Gly Gly Lys Tyr Phe Tyr Ile Asn Asp Ser Gly Asp Val 
65                  70                  75                  80  


Trp Ser Pro Gly Trp Lys Pro Val Lys Ala Glu Leu Asp Ala Tyr Ser 
                85                  90                  95      


Cys Ala His Gly Leu Ser Tyr Thr Arg Ile Thr Gly Glu Arg Asn Gly 
            100                 105                 110         


Ile Gln Ala Glu Val Leu Ser Phe Ile Pro Leu Gly Thr Trp Ala Glu 
        115                 120                 125             


Ile Gln Lys Val Ser Leu Lys Asn Thr Ser Gly Ala Thr Lys Lys Phe 
    130                 135                 140                 


Lys Leu Phe Ser Phe Ala Glu Trp Cys Leu Trp Asn Ala Glu Asp Asp 
145                 150                 155                 160 


Met Thr Asn Phe Gln Arg Asn Phe Ser Thr Gly Glu Val Glu Val Glu 
                165                 170                 175     


Asp Ser Val Ile Tyr His Lys Thr Glu Phe Lys Glu Arg Arg Asn His 
            180                 185                 190         


Tyr Ala Phe Tyr Ser Val Asn Ala Pro Ile Gln Gly Phe Asp Thr Asp 
        195                 200                 205             


Arg Asp Lys Trp Lys Gly Leu Tyr Asn Asp Phe Asp Lys Pro Asp Ala 
    210                 215                 220                 


Val Phe Glu Gly Glu Pro Arg Asn Ser Glu Ala His Gly Trp Ser Pro 
225                 230                 235                 240 


Ile Ala Ser His Tyr Leu Glu Val Glu Leu Ala Pro Gly Glu Ser Lys 
                245                 250                 255     


Asp Leu Ile Phe Val Leu Gly Tyr Ile Glu Val Ala Pro Glu Asn Lys 
            260                 265                 270         


Trp Glu Ser Lys Gly Val Ile Asn Lys Ser Pro Ala Lys Glu Leu Ile 
        275                 280                 285             


Ala Arg Phe Asp Ser Val Glu Lys Val Asp Ala Glu Leu Thr Lys Leu 
    290                 295                 300                 


Ala Asp Tyr Trp Ala Asn Leu Leu Ser Thr Tyr Ser Val Glu Ser Gly 
305                 310                 315                 320 


Asp Glu Lys Leu Asp Arg Met Val Asn Ile Trp Asn Gln Tyr Gln Cys 
                325                 330                 335     


Met Val Thr Phe Asn Met Ser Arg Ser Ala Ser Phe Phe Glu Ser Gly 
            340                 345                 350         


Ile Gly Arg Gly Met Gly Phe Arg Asp Ser Asn Gln Asp Leu Ile Gly 
        355                 360                 365             


Phe Val His Gln Val Pro Glu Arg Ala Arg Glu Arg Ile Ile Asp Ile 
    370                 375                 380                 


Ala Ser Thr Gln Phe Glu Asp Gly Ser Ala Tyr His Gln Tyr Gln Pro 
385                 390                 395                 400 


Leu Thr Lys Arg Gly Asn Asn Ala Ile Gly Gly Asn Phe Asn Asp Asp 
                405                 410                 415     


Pro Leu Trp Leu Ile Leu Ser Thr Thr Asp Tyr Ile Lys Glu Thr Gly 
            420                 425                 430         


Asp Phe Ser Ile Leu Glu Glu Gln Val Pro Tyr Asp Asn Asp Ala Ser 
        435                 440                 445             


Lys Ala Thr Ser His Phe Glu His Leu Lys Arg Ser Phe Tyr His Thr 
    450                 455                 460                 


Val Asn Asn Leu Gly Pro His Gly Leu Pro Leu Ile Gly Arg Ala Asp 
465                 470                 475                 480 


Trp Asn Asp Cys Leu Asn Leu Asn Cys Phe Ser Glu Asp Pro Asn Glu 
                485                 490                 495     


Ser Phe Gln Thr Thr Gly Asn Lys Thr Gly Arg Thr Ala Glu Ser Leu 
            500                 505                 510         


Met Ile Ala Gly Leu Phe Val Leu Tyr Gly Asn Glu Phe Val Lys Leu 
        515                 520                 525             


Cys Arg Glu Ile Gly Gln Asp Gly Glu Ala Ala Glu Ala Gln Ala His 
    530                 535                 540                 


Ile Asp Gln Met Val Glu Ala Val Lys Lys His Gly Trp Asp Gly Glu 
545                 550                 555                 560 


Trp Phe Leu Arg Ala Tyr Asp Tyr Tyr Gly Lys Lys Val Gly Ser Lys 
                565                 570                 575     


Glu Asn Glu Glu Gly Lys Ile Phe Ile Glu Ser Gln Gly Phe Cys Gly 
            580                 585                 590         


Met Ala Gly Ile Gly Leu Glu Asp Gly Leu Val Glu Lys Ser Met Asp 
        595                 600                 605             


Ser Val Lys Glu Trp Leu Asp Cys Asp Tyr Gly Ile Val Leu Gln Gln 
    610                 615                 620                 


Pro Ala Phe Thr Lys Tyr Tyr Ile Glu Tyr Gly Glu Ile Ser Thr Tyr 
625                 630                 635                 640 


Pro Ala Gly Tyr Lys Glu Asn Ala Gly Ile Phe Cys His Asn Asn Pro 
                645                 650                 655     


Trp Ile Met Ile Thr Glu Thr Leu Leu Gly Arg Gly Asp Lys Ala Phe 
            660                 665                 670         


Glu Tyr Tyr Arg Lys Ile Ala Pro Ala Tyr Leu Glu Glu Ile Ser Asp 
        675                 680                 685             


Leu His Lys Val Glu Pro Tyr Ala Tyr Cys Gln Met Ile Ala Gly Lys 
    690                 695                 700                 


Asp Ala Tyr Leu Pro Gly Glu Gly Lys Asn Ser Trp Leu Thr Gly Thr 
705                 710                 715                 720 


Ala Ser Trp Asn Phe Ala Ala Ile Thr Gln Tyr Ile Leu Gly Val Lys 
                725                 730                 735     


Pro Asp Tyr Ser Gly Leu Ala Ile Asn Pro Cys Ile Pro Ser Ser Trp 
            740                 745                 750         


Asp Gly Phe Lys Val Thr Arg Lys Tyr Arg Gly Ala Thr Tyr Asn Ile 
        755                 760                 765             


Ile Val Thr Asn Pro Thr His Val Ser Lys Gly Val Lys Ser Leu Thr 
    770                 775                 780                 


Leu Asn Gly Asn Ala Ile Asp Gly Tyr Ile Val Pro Pro Gln Gln Ala 
785                 790                 795                 800 


Gly Thr Val Cys Asn Val Glu Val Thr Leu Gly 
                805                 810     


<210>  8
<211>  813
<212>  PRT
<213>  Thermotoga maritimans

<400>  8

Met Arg Phe Gly Tyr Phe Asp Asp Val Asn Arg Glu Tyr Val Ile Thr 
1               5                   10                  15      


Thr Pro Gln Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Thr Glu Asp 
            20                  25                  30          


Phe Phe Ser Ile Ile Ser His Met Ala Gly Gly Tyr Cys Phe Tyr Lys 
        35                  40                  45              


Asp Ala Arg Leu Arg Arg Ile Thr Arg Phe Arg Tyr Asn Asn Val Pro 
    50                  55                  60                  


Thr Asp Ala Gly Gly Arg Tyr Phe Tyr Ile Arg Glu Glu Asn Gly Asp 
65                  70                  75                  80  


Phe Trp Thr Pro Thr Trp Met Pro Val Arg Lys Asp Leu Ser Phe Phe 
                85                  90                  95      


Glu Ala Arg His Gly Leu Gly Tyr Thr Lys Ile Thr Gly Glu Arg Asn 
            100                 105                 110         


Gly Leu Arg Ala Thr Ile Thr Tyr Phe Val Pro Arg His Phe Thr Gly 
        115                 120                 125             


Glu Val His Tyr Leu Val Leu Glu Asn Lys Ala Glu Lys Pro Arg Lys 
    130                 135                 140                 


Ile Lys Leu Phe Ser Phe Ile Glu Phe Cys Leu Trp Asn Ala Leu Asp 
145                 150                 155                 160 


Asp Met Thr Asn Phe Gln Arg Asn Tyr Ser Thr Gly Glu Val Glu Ile 
                165                 170                 175     


Glu Gly Ser Val Ile Tyr His Lys Thr Glu Tyr Arg Glu Arg Arg Asn 
            180                 185                 190         


His Tyr Ala Phe Tyr Ser Val Asn Gln Pro Ile Asp Gly Phe Asp Thr 
        195                 200                 205             


Asp Arg Glu Ser Phe Ile Gly Leu Tyr Ser Gly Phe Glu Ala Pro Gln 
    210                 215                 220                 


Ala Val Val Glu Gly Lys Pro Arg Asn Ser Val Ala Ser Gly Trp Ala 
225                 230                 235                 240 


Pro Ile Ala Ser His Tyr Leu Glu Ile Glu Leu Ala Pro Ser Glu Lys 
                245                 250                 255     


Lys Glu Leu Ile Phe Ile Leu Gly Tyr Val Glu Asn Pro Glu Glu Glu 
            260                 265                 270         


Lys Trp Glu Lys Pro Gly Val Ile Asn Lys Lys Arg Ala Lys Glu Met 
        275                 280                 285             


Ile Glu Lys Phe Lys Thr Gly Glu Asp Val Glu His Ala Leu Lys Glu 
    290                 295                 300                 


Leu Arg Glu Tyr Trp Asp Asp Leu Leu Gly Arg Ile Gln Val Glu Thr 
305                 310                 315                 320 


His Asp Glu Lys Leu Asn Arg Met Val Asn Ile Trp Asn Gln Tyr Gln 
                325                 330                 335     


Cys Met Val Thr Phe Asn Ile Ser Arg Ser Ala Ser Tyr Phe Glu Ser 
            340                 345                 350         


Gly Ile Ser Arg Gly Ile Gly Phe Arg Asp Ser Asn Gln Asp Ile Leu 
        355                 360                 365             


Gly Phe Val His Met Ile Pro Glu Lys Ala Arg Gln Arg Ile Leu Asp 
    370                 375                 380                 


Leu Ala Ser Ile Gln Phe Glu Asp Gly Ser Thr Tyr His Gln Phe Gln 
385                 390                 395                 400 


Pro Leu Thr Lys Lys Gly Asn Asn Glu Ile Gly Gly Gly Phe Asn Asp 
                405                 410                 415     


Asp Pro Leu Trp Leu Ile Leu Ser Thr Ser Ala Tyr Ile Lys Glu Thr 
            420                 425                 430         


Gly Asp Trp Ser Ile Leu Gly Glu Glu Val Pro Phe Asp Asn Asp Pro 
        435                 440                 445             


Asn Lys Lys Ala Ser Leu Phe Glu His Leu Lys Arg Ser Phe Tyr Phe 
    450                 455                 460                 


Thr Val Asn Asn Leu Gly Pro His Gly Leu Pro Leu Ile Gly Arg Ala 
465                 470                 475                 480 


Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys Phe Ser Lys Asn Pro Asp 
                485                 490                 495     


Glu Ser Phe Gln Thr Thr Val Asn Ala Leu Asp Gly Arg Val Ala Glu 
            500                 505                 510         


Ser Val Phe Ile Ala Gly Leu Phe Val Leu Ala Gly Lys Glu Phe Val 
        515                 520                 525             


Glu Ile Cys Lys Arg Arg Gly Leu Glu Glu Glu Ala Arg Glu Ala Glu 
    530                 535                 540                 


Lys His Val Asn Lys Met Ile Glu Thr Thr Leu Lys Tyr Gly Trp Asp 
545                 550                 555                 560 


Gly Glu Trp Phe Leu Arg Ala Tyr Asp Ala Phe Gly Arg Lys Val Gly 
                565                 570                 575     


Ser Lys Glu Cys Glu Glu Gly Lys Ile Phe Ile Glu Pro Gln Gly Met 
            580                 585                 590         


Cys Val Met Ala Gly Ile Gly Val Asp Asn Gly Tyr Ala Glu Lys Ala 
        595                 600                 605             


Leu Asp Ser Val Lys Lys Tyr Leu Asp Thr Pro Tyr Gly Leu Val Leu 
    610                 615                 620                 


Gln Gln Pro Ala Tyr Ser Arg Tyr Tyr Ile Glu Leu Gly Glu Ile Ser 
625                 630                 635                 640 


Ser Tyr Pro Pro Gly Tyr Lys Glu Asn Ala Gly Ile Phe Cys His Asn 
                645                 650                 655     


Asn Pro Trp Val Ala Ile Ala Glu Thr Val Ile Gly Arg Gly Asp Arg 
            660                 665                 670         


Ala Phe Glu Ile Tyr Arg Lys Ile Thr Pro Ala Tyr Leu Glu Asp Ile 
        675                 680                 685             


Ser Glu Ile His Arg Thr Glu Pro Tyr Val Tyr Ala Gln Met Val Ala 
    690                 695                 700                 


Gly Lys Asp Ala Pro Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr 
705                 710                 715                 720 


Gly Thr Ala Ala Trp Ser Phe Val Ala Ile Thr Gln His Ile Leu Gly 
                725                 730                 735     


Ile Arg Pro Thr Tyr Asp Ser Leu Val Val Asp Pro Cys Ile Pro Lys 
            740                 745                 750         


Glu Trp Glu Gly Phe Arg Ile Thr Arg Lys Phe Arg Gly Ser Ile Tyr 
        755                 760                 765             


Asp Ile Thr Val Lys Asn Pro Ser His Val Ser Lys Gly Val Lys Glu 
    770                 775                 780                 


Ile Ile Val Asp Gly Lys Lys Ile Glu Gly Gln Val Leu Pro Val Phe 
785                 790                 795                 800 


Glu Asp Gly Lys Val His Arg Val Glu Val Val Met Gly 
                805                 810             


<210>  9
<211>  813
<212>  PRT
<213>  Thermotoga maritimans

<400>  9

Met Lys Phe Gly Tyr Phe Asp Asp Lys Asn Arg Glu Tyr Val Ile Val 
1               5                   10                  15      


Thr Pro Arg Thr Pro Tyr Pro Trp Ile Asn Tyr Leu Gly Thr Glu Asp 
            20                  25                  30          


Phe Phe Ser Ile Ile Ser His Met Ala Gly Gly Tyr Cys Phe Tyr Lys 
        35                  40                  45              


Asp Ala Arg Leu Arg Arg Ile Thr Arg Phe Arg Tyr Asn Asn Val Pro 
    50                  55                  60                  


Thr Asp Ala Gly Gly Arg Tyr Phe Tyr Ile Arg Glu Glu Asp Gly Asp 
65                  70                  75                  80  


Phe Trp Ser Pro Thr Trp Met Pro Val Arg Arg Asp Leu Ser Phe Phe 
                85                  90                  95      


Glu Ala Arg His Gly Leu Gly Tyr Thr Lys Ile Ala Gly Asp Ile Asn 
            100                 105                 110         


Gly Leu Arg Ala Thr Ile Thr Phe Phe Val Pro Arg His Phe Thr Gly 
        115                 120                 125             


Glu Val His His Leu Val Leu Gln Asn Arg Thr Glu Arg Pro Arg Arg 
    130                 135                 140                 


Ile Lys Leu Phe Ser Phe Ile Glu Phe Cys Leu Trp Asn Ala Leu Asp 
145                 150                 155                 160 


Asp Met Thr Asn Phe Gln Arg Asn Tyr Ser Thr Gly Glu Val Glu Ile 
                165                 170                 175     


Glu Gly Ser Val Ile Tyr His Lys Thr Glu Tyr Arg Glu Arg Arg Asn 
            180                 185                 190         


His Tyr Ala Phe Tyr Ser Val Asn His Ser Ile Asp Gly Phe Asp Thr 
        195                 200                 205             


Asp Arg Glu Ser Phe Met Gly Leu Tyr Asn Gly Phe Glu Ala Pro Gln 
    210                 215                 220                 


Ala Val Val Glu Gly Asn Pro Arg Asn Ser Val Ala Ser Gly Trp Ala 
225                 230                 235                 240 


Pro Ile Ala Ser His Tyr Leu Glu Leu Glu Ile Pro Pro Leu Gly Glu 
                245                 250                 255     


Lys Glu Leu Ile Phe Ile Leu Gly Tyr Val Glu Asn Pro Glu Glu Glu 
            260                 265                 270         


Lys Trp Glu Arg Pro Gly Val Ile Asn Lys Lys Arg Ala Lys Glu Met 
        275                 280                 285             


Ile Glu Arg Phe Lys Thr Gly Glu Asp Val Glu Arg Ala Leu Lys Glu 
    290                 295                 300                 


Leu Lys Glu Tyr Trp Asp Glu Leu Leu Gly Arg Ile Gln Val Glu Thr 
305                 310                 315                 320 


His Asp Glu Lys Leu Asn Arg Met Val Asn Ile Trp Asn Gln Tyr Gln 
                325                 330                 335     


Cys Met Val Thr Phe Asn Ile Ala Arg Thr Ser Ser Tyr Phe Glu Ser 
            340                 345                 350         


Gly Ile Ser Arg Gly Ile Gly Phe Arg Asp Ser Asn Gln Asp Ile Leu 
        355                 360                 365             


Gly Phe Val His Met Ile Pro Glu Lys Ala Arg Gln Arg Ile Leu Asp 
    370                 375                 380                 


Leu Ala Ser Ile Gln Phe Glu Asp Gly Ser Thr Tyr His Gln Phe Gln 
385                 390                 395                 400 


Pro Leu Thr Lys Lys Gly Asn Asn Glu Ile Gly Gly Gly Phe Asn Asp 
                405                 410                 415     


Asp Pro Leu Trp Leu Ile Leu Ser Thr Ser Ala Tyr Ile Lys Glu Thr 
            420                 425                 430         


Gly Asp Trp Ser Ile Leu Asn Glu Glu Val Pro Phe Asp Asn Asp Pro 
        435                 440                 445             


Asp Lys Lys Ala Thr Leu Phe Glu His Leu Lys Arg Ser Phe Tyr Phe 
    450                 455                 460                 


Thr Val Asn Asn Leu Gly Pro His Gly Leu Pro Leu Ile Gly Arg Ala 
465                 470                 475                 480 


Asp Trp Asn Asp Cys Leu Asn Leu Asn Cys Phe Ser Lys Asn Pro Asp 
                485                 490                 495     


Glu Ser Phe Gln Thr Thr Val Asn Ala Leu Asp Gly Arg Val Ala Glu 
            500                 505                 510         


Ser Val Phe Ile Ala Gly Leu Phe Val Leu Ala Gly Lys Glu Phe Val 
        515                 520                 525             


Glu Ile Cys Arg Arg Leu Gly Leu Glu Asp Glu Ala Lys Glu Ala Glu 
    530                 535                 540                 


Lys His Val Lys Lys Met Ile Glu Thr Thr Leu Glu Tyr Gly Trp Asp 
545                 550                 555                 560 


Gly Glu Trp Phe Leu Arg Ala Tyr Asp Ala Phe Gly Arg Lys Val Gly 
                565                 570                 575     


Ser Lys Glu Cys Glu Glu Gly Lys Ile Phe Ile Glu Pro Gln Gly Met 
            580                 585                 590         


Cys Val Met Ala Gly Ile Gly Val Glu Asn Gly Tyr Ala Lys Lys Ala 
        595                 600                 605             


Leu Asp Ser Val Lys Glu His Leu Asp Thr His Tyr Gly Leu Val Leu 
    610                 615                 620                 


Gln Gln Pro Ala Tyr Ser Arg Tyr Tyr Ile Glu Leu Gly Glu Ile Ser 
625                 630                 635                 640 


Ser Tyr Pro Pro Gly Tyr Lys Glu Asn Ala Gly Ile Phe Cys His Asn 
                645                 650                 655     


Asn Pro Trp Val Ala Ile Ala Glu Ser Val Ile Gly Arg Gly Asp Arg 
            660                 665                 670         


Ala Phe Glu Ile Tyr Arg Lys Ile Thr Pro Ala Tyr Leu Glu Asp Ile 
        675                 680                 685             


Ser Glu Ile His Arg Thr Glu Pro Tyr Val Tyr Ala Gln Met Val Ala 
    690                 695                 700                 


Gly Lys Asp Ala Pro Arg His Gly Glu Ala Lys Asn Ser Trp Leu Thr 
705                 710                 715                 720 


Gly Thr Ala Ala Trp Ser Phe Val Ala Ile Thr Gln Tyr Ile Leu Gly 
                725                 730                 735     


Val Arg Pro Thr Tyr Asp Gly Leu Met Val Asp Pro Cys Ile Pro Glu 
            740                 745                 750         


Asp Trp Asp Gly Phe Lys Ile Thr Arg Arg Phe Arg Gly Ala Thr Tyr 
        755                 760                 765             


Glu Ile Thr Val Lys Asn Pro His His Val Ser Lys Gly Val Lys Glu 
    770                 775                 780                 


Ile Ile Val Asp Gly Lys Lys Ile Glu Gly Gln Val Leu Pro Val Phe 
785                 790                 795                 800 


Asn Asp Gly Lys Val His Arg Val Glu Val Leu Met Gly 
                805                 810             


