 SEQUENCE LISTING

<110>  Wuhan Institute of Virology, Chinese Academy of Sciences; 
       йѧԺ人о
 
<120>  IMMUNOGLOBULIN G MONOCLONAL ANTIBODIES AGAINST 3D PROTEINS OF ENTEROVIRUSES

<130>  1002.P002

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence


<220>
<221>  PEPTIDE
<222>  (1)..(8)
<223>  X7 stands for T, H, R or N; X8 stands for S, N or K

<400>  1

Lys Glu Pro Ala Val Leu Xaa Xaa 
1               5               


<210>  2
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence


<220>
<221>  PEPTIDE
<222>  (1)..(15)
<223>  X1 stands for Y, M, L or F; X2 stands for S or V; X4 stands for Y
       or F; X12 stands for L, A, K or R; X13 stands for D, E, T or S; 
       X15 stands for I or V

<400>  2

Xaa Xaa Thr Xaa Val Lys Asp Glu Leu Arg Ser Xaa Xaa Lys Xaa 
1               5                   10                  15  


<210>  3
<211>  8
<212>  PRT
<213>  Enterovirus 71

<400>  3

Lys Glu Pro Ala Val Leu Thr Ser 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  Enterovirus 71

<400>  4

Lys Glu Pro Ala Val Leu His Ser 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Coxsackievirus

<400>  5

Lys Glu Pro Ala Val Leu Arg Asn 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Enterovirus C

<400>  6

Lys Glu Pro Ala Val Leu Thr Lys 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  enterovirus 68

<400>  7

Lys Glu Pro Ala Val Leu Asn Ser 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  enterovirus 94

<400>  8

Lys Glu Pro Ala Val Leu His Ser 
1               5               


<210>  9
<211>  15
<212>  PRT
<213>  Enterovirus 71

<400>  9

Tyr Ser Thr Tyr Val Lys Asp Glu Leu Arg Ser Leu Asp Lys Ile 
1               5                   10                  15  


<210>  10
<211>  15
<212>  PRT
<213>  Coxsackievirus

<400>  10

Met Val Thr Tyr Val Lys Asp Glu Leu Arg Ser Ala Glu Lys Val 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  Enterovirus C

<400>  11

Leu Val Thr Tyr Val Lys Asp Glu Leu Arg Ser Lys Thr Lys Val 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  coxsackievirus A1

<400>  12

Leu Val Thr Tyr Val Lys Asp Glu Leu Arg Ser Lys Ser Lys Val 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  enterovirus 68

<400>  13

Phe Val Thr Phe Val Lys Asp Glu Leu Arg Ser Arg Glu Lys Val 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  enterovirus 94

<400>  14

Phe Val Thr Phe Val Lys Asp Glu Leu Arg Ser Arg Glu Lys Val 
1               5                   10                  15  


<210>  15
<211>  462
<212>  PRT
<213>  Enterovirus 71

<400>  15

Gly Glu Ile Gln Trp Met Lys Pro Asn Arg Glu Thr Gly Arg Leu Asn 
1               5                   10                  15      


Ile Asn Gly Pro Thr Arg Thr Lys Leu Glu Pro Ser Val Phe His Asp 
            20                  25                  30          


Val Phe Glu Gly Asn Lys Glu Pro Ala Val Leu Thr Ser Lys Asp Pro 
        35                  40                  45              


Arg Leu Glu Val Asp Phe Glu Gln Ala Leu Phe Ser Lys Tyr Val Gly 
    50                  55                  60                  


Asn Thr Leu His Glu Pro Asp Glu Tyr Val Thr Gln Ala Ala Leu His 
65                  70                  75                  80  


Tyr Ala Asn Gln Leu Lys Gln Leu Asp Ile Asn Thr Ser Lys Met Ser 
                85                  90                  95      


Met Glu Glu Ala Cys Tyr Gly Thr Glu Tyr Leu Glu Ala Ile Asp Leu 
            100                 105                 110         


His Thr Ser Ala Gly Tyr Pro Tyr Ser Ala Leu Gly Ile Lys Lys Arg 
        115                 120                 125             


Asp Ile Leu Asp Pro Val Thr Arg Asp Thr Ser Arg Met Lys Leu Tyr 
    130                 135                 140                 


Met Asp Lys Tyr Gly Leu Asp Leu Pro Tyr Ser Thr Tyr Val Lys Asp 
145                 150                 155                 160 


Glu Leu Arg Ser Leu Asp Lys Ile Arg Lys Gly Lys Ser Arg Leu Ile 
                165                 170                 175     


Glu Ala Ser Ser Leu Asn Asp Ser Val Tyr Leu Arg Met Thr Phe Gly 
            180                 185                 190         


His Leu Tyr Glu Val Phe His Ala Asn Pro Gly Thr Val Thr Gly Ser 
        195                 200                 205             


Ala Val Gly Cys Asn Pro Asp Val Phe Trp Ser Lys Leu Pro Ile Leu 
    210                 215                 220                 


Leu Pro Gly Ser Leu Phe Ala Phe Asp Tyr Ser Gly Tyr Asp Ala Ser 
225                 230                 235                 240 


Leu Ser Pro Val Trp Phe Arg Ala Leu Glu Leu Val Leu Arg Glu Ile 
                245                 250                 255     


Gly Tyr Ser Glu Glu Ala Val Ser Leu Ile Glu Gly Ile Asn His Thr 
            260                 265                 270         


His His Val Tyr Arg Asn Lys Thr Tyr Cys Val Leu Gly Gly Met Pro 
        275                 280                 285             


Ser Gly Cys Ser Gly Thr Ser Ile Phe Asn Ser Met Ile Asn Asn Ile 
    290                 295                 300                 


Ile Ile Arg Thr Leu Leu Ile Lys Thr Phe Lys Gly Ile Asp Leu Asp 
305                 310                 315                 320 


Glu Leu Lys Met Val Ala Tyr Gly Asp Asp Val Leu Ala Ser Tyr Pro 
                325                 330                 335     


Phe Pro Ile Asp Cys Leu Glu Leu Ala Lys Thr Gly Lys Glu Tyr Gly 
            340                 345                 350         


Leu Thr Met Thr Pro Ala Asp Lys Ser Pro Cys Phe Asn Glu Val Thr 
        355                 360                 365             


Trp Glu Asn Ala Thr Phe Leu Lys Arg Gly Phe Leu Pro Asp His Gln 
    370                 375                 380                 


Phe Pro Phe Leu Ile His Pro Thr Met Pro Met Arg Glu Ile His Glu 
385                 390                 395                 400 


Ser Ile Arg Trp Thr Lys Asp Ala Arg Asn Thr Gln Asp His Val Arg 
                405                 410                 415     


Ser Leu Cys Leu Leu Ala Trp His Asn Gly Lys Glu Glu Tyr Glu Lys 
            420                 425                 430         


Phe Val Ser Thr Ile Arg Ser Val Pro Ile Gly Arg Ala Leu Ala Ile 
        435                 440                 445             


Pro Asn Phe Glu Asn Leu Arg Arg Asn Trp Leu Glu Leu Phe 
    450                 455                 460         


<210>  16
<211>  461
<212>  PRT
<213>  Coxsackievirus

<400>  16

Gly Glu Ile Gln Trp Met Lys Ser Asn Lys Glu Thr Gly Arg Leu Asn 
1               5                   10                  15      


Ile Asn Gly Pro Thr Arg Thr Lys Leu Glu Pro Ser Val Phe His Asp 
            20                  25                  30          


Val Phe Glu Gly Asp Lys Glu Pro Ala Val Leu Thr Ser Lys Asp Pro 
        35                  40                  45              


Arg Leu Glu Val Asp Phe Glu Gln Ala Leu Phe Ser Lys Tyr Val Gly 
    50                  55                  60                  


Asn Thr Leu His Glu Pro Asp Glu Tyr Val Thr Gln Ala Ala Leu His 
65                  70                  75                  80  


Tyr Ala Asn Gln Leu Lys Gln Leu Asp Ile Asn Thr Asn Lys Met Ser 
                85                  90                  95      


Met Glu Glu Ala Cys Tyr Gly Thr Glu Tyr Leu Glu Ala Ile Asp Leu 
            100                 105                 110         


His Thr Ser Ala Gly Tyr Tyr Ser Ala Leu Gly Val Lys Lys Arg Asp 
        115                 120                 125             


Ile Leu Asp Pro Ile Thr Arg Asp Thr Thr Lys Met Lys Phe Tyr Met 
    130                 135                 140                 


Asp Lys Tyr Gly Leu Asp Leu Pro Tyr Ser Thr Tyr Val Lys Asp Glu 
145                 150                 155                 160 


Leu Arg Ser Leu Asp Lys Ile Lys Lys Gly Lys Ser Arg Leu Ile Glu 
                165                 170                 175     


Ala Ser Ser Leu Asn Asp Ser Val Tyr Leu Arg Met Thr Phe Gly His 
            180                 185                 190         


Leu Tyr Glu Thr Phe His Ala Asn Pro Gly Thr Val Thr Gly Ser Ala 
        195                 200                 205             


Val Gly Cys Asn Pro Asp Val Phe Trp Ser Lys Leu Pro Ile Leu Leu 
    210                 215                 220                 


Pro Gly Ser Leu Phe Ala Phe Asp Tyr Ser Gly Tyr Asp Ala Ser Leu 
225                 230                 235                 240 


Ser Pro Val Trp Phe Arg Ala Leu Glu Val Val Leu Arg Glu Ile Gly 
                245                 250                 255     


Tyr Ser Glu Glu Ala Val Ser Leu Ile Glu Gly Ile Asn His Thr His 
            260                 265                 270         


His Val Tyr Arg Asn Lys Thr Tyr Cys Val Leu Gly Gly Met Pro Ser 
        275                 280                 285             


Gly Cys Ser Gly Thr Ser Ile Phe Asn Ser Met Ile Asn Asn Ile Ile 
    290                 295                 300                 


Ile Arg Thr Leu Leu Ile Lys Pro Phe Asn Gly Ile Asp Leu Asp Glu 
305                 310                 315                 320 


Leu Asn Met Val Asp His Gly Asp Asp Val Leu Ala Ser Tyr Pro Phe 
                325                 330                 335     


Pro Ile Asp Cys Ser Glu Leu Ala Glu Gln Gly Lys Glu Tyr Arg Leu 
            340                 345                 350         


Thr Met Thr Pro Asp Asp Lys Ser Ser Cys Phe Asn Glu Val Thr Arg 
        355                 360                 365             


Glu Asn Ala Thr Phe Leu Lys Arg Gly Phe Leu Pro Asp His Gln Phe 
    370                 375                 380                 


Pro Phe Ile Ile His Pro Thr Met Pro Met Arg Glu Ile Pro Glu Ser 
385                 390                 395                 400 


Ile Arg Trp Ser Lys Asp Ala Arg Asn Thr Gln Asp His Val Arg Ser 
                405                 410                 415     


Leu Cys Leu Leu Ala Trp His Asn Gly Lys Glu Glu Tyr Glu Lys Phe 
            420                 425                 430         


Ala Ser Thr Ile Arg Ser Val Pro Ile Gly Lys Ala Leu Ala Ile Pro 
        435                 440                 445             


Asn Phe Glu Asn Ser Arg Arg Asn Trp Leu Glu Leu Phe 
    450                 455                 460     


<210>  17
<211>  462
<212>  PRT
<213>  Enterovirus B

<400>  17

Gly Glu Ile Glu Phe Ile Glu Ser Ser Lys Asp Ala Gly Phe Pro Val 
1               5                   10                  15      


Ile Asn Thr Pro Ser Lys Thr Lys Leu Glu Pro Ser Val Phe His Gln 
            20                  25                  30          


Val Phe Glu Gly Asn Lys Glu Pro Ala Val Leu Arg Asn Gly Asp Pro 
        35                  40                  45              


Arg Leu Lys Ala Asn Phe Glu Glu Ala Ile Phe Ser Lys Tyr Ile Gly 
    50                  55                  60                  


Asn Val Asn Thr His Val Asp Glu Tyr Met Met Glu Ala Val Asp His 
65                  70                  75                  80  


Tyr Ala Gly Gln Leu Ala Thr Leu Asp Ile Asn Thr Glu Pro Met Lys 
                85                  90                  95      


Leu Glu Glu Ala Val Tyr Gly Thr Glu Gly Leu Glu Ala Leu Asp Leu 
            100                 105                 110         


Thr Thr Ser Ala Gly Tyr Pro Tyr Val Ala Leu Gly Ile Lys Lys Arg 
        115                 120                 125             


Asp Ile Leu Ser Lys Lys Thr Lys Asp Leu Thr Lys Leu Lys Glu Cys 
    130                 135                 140                 


Met Asp Lys Tyr Gly Leu Asn Leu Pro Met Val Thr Tyr Val Lys Asp 
145                 150                 155                 160 


Glu Leu Arg Ser Ala Glu Lys Val Ala Lys Gly Lys Ser Arg Leu Ile 
                165                 170                 175     


Glu Ala Ser Ser Leu Asn Asp Ser Val Ala Met Arg Gln Thr Phe Gly 
            180                 185                 190         


Asn Leu Tyr Lys Thr Phe His Leu Asn Pro Gly Ile Val Thr Gly Ser 
        195                 200                 205             


Ala Val Gly Cys Asp Pro Asp Leu Phe Trp Ser Lys Ile Pro Val Met 
    210                 215                 220                 


Leu Asp Gly His Leu Ile Ala Phe Asp Tyr Ser Gly Tyr Asp Ala Ser 
225                 230                 235                 240 


Leu Ser Pro Val Trp Phe Ala Cys Leu Lys Met Leu Leu Glu Lys Leu 
                245                 250                 255     


Gly Tyr Ser His Lys Glu Thr Asn Tyr Ile Asp Tyr Leu Cys Asn Ser 
            260                 265                 270         


His His Leu Tyr Arg Asp Lys His Tyr Phe Val Arg Gly Gly Met Pro 
        275                 280                 285             


Ser Gly Cys Ser Gly Thr Ser Ile Phe Asn Ser Met Ile Asn Asn Ile 
    290                 295                 300                 


Ile Ile Arg Thr Leu Met Leu Lys Val Tyr Lys Gly Ile Asp Leu Asp 
305                 310                 315                 320 


Gln Phe Arg Met Ile Ala Tyr Gly Asp Asp Val Ile Ala Ser Tyr Pro 
                325                 330                 335     


Trp Pro Ile Asp Ala Ser Leu Leu Ala Glu Ala Gly Lys Gly Tyr Gly 
            340                 345                 350         


Leu Ile Met Thr Pro Ala Asp Lys Gly Glu Cys Phe Asn Glu Val Thr 
        355                 360                 365             


Trp Thr Asn Val Thr Phe Leu Lys Arg Tyr Phe Arg Ala Asp Glu Gln 
    370                 375                 380                 


Tyr Pro Phe Leu Val His Pro Val Met Pro Met Lys Asp Ile His Glu 
385                 390                 395                 400 


Ser Ile Arg Trp Thr Lys Asp Pro Lys Asn Thr Gln Asp His Val Arg 
                405                 410                 415     


Ser Leu Cys Leu Leu Ala Trp His Asn Gly Glu His Glu Tyr Glu Glu 
            420                 425                 430         


Phe Ile Lys Lys Ile Arg Ser Val Pro Val Gly Arg Cys Leu Ala Leu 
        435                 440                 445             


Pro Ala Phe Ser Ala Leu Arg Arg Lys Trp Leu Asp Ser Phe 
    450                 455                 460         


<210>  18
<211>  462
<212>  PRT
<213>  Coxsackievirus

<400>  18

Gly Glu Ile Glu Phe Ile Glu Ser Ser Lys Asp Ala Gly Phe Pro Ile 
1               5                   10                  15      


Ile Asn Thr Pro Ser Lys Thr Lys Leu Glu Pro Ser Val Phe His Gln 
            20                  25                  30          


Val Phe Glu Gly Val Lys Glu Pro Ala Val Leu Arg Asn Gly Asp Pro 
        35                  40                  45              


Arg Leu Lys Ala Asn Phe Glu Glu Ala Ile Phe Ser Lys Tyr Ile Gly 
    50                  55                  60                  


Asn Val Asn Thr His Val Asp Glu Tyr Met Leu Glu Ala Val Asp His 
65                  70                  75                  80  


Tyr Ala Gly Gln Leu Ala Thr Leu Asp Ile Ser Thr Glu Pro Met Lys 
                85                  90                  95      


Leu Glu Asp Ala Val Tyr Gly Thr Glu Gly Leu Glu Ala Leu Asp Leu 
            100                 105                 110         


Thr Thr Ser Ala Gly Tyr Pro Tyr Val Ala Leu Gly Ile Lys Lys Arg 
        115                 120                 125             


Asp Ile Leu Ser Lys Lys Thr Arg Asp Leu Thr Lys Leu Lys Glu Cys 
    130                 135                 140                 


Met Asp Lys Tyr Gly Leu Asn Leu Pro Met Ile Thr Tyr Val Lys Asp 
145                 150                 155                 160 


Gln Leu Arg Ser Ala Glu Lys Val Ala Lys Gly Lys Ser Arg Leu Ile 
                165                 170                 175     


Glu Ala Ser Ser Leu Asn Asp Ser Val Ala Met Arg Gln Thr Phe Gly 
            180                 185                 190         


Asn Leu Tyr Lys Thr Phe His Leu Asn Pro Gly Ile Val Thr Gly Ser 
        195                 200                 205             


Ala Val Gly Cys Asp Pro Asp Leu Phe Trp Ser Lys Ile Pro Val Met 
    210                 215                 220                 


Leu Asn Gly His Leu Ile Ala Phe Asp Tyr Ser Gly Tyr Asp Ala Ser 
225                 230                 235                 240 


Leu Ser Pro Val Trp Phe Ala Cys Leu Lys Leu Leu Leu Glu Lys Leu 
                245                 250                 255     


Gly Tyr Ser His Lys Glu Thr Asn Tyr Ile Asp Tyr Leu Cys Asn Ser 
            260                 265                 270         


His His Leu Tyr Arg Asp Lys His Tyr Phe Val Arg Gly Gly Met Pro 
        275                 280                 285             


Ser Gly Cys Ser Gly Thr Ser Ile Phe Asn Ser Met Ile Asn Asn Ile 
    290                 295                 300                 


Ile Ile Arg Thr Leu Met Leu Lys Val Tyr Lys Gly Ile Asp Leu Asp 
305                 310                 315                 320 


Gln Phe Arg Met Ile Ala Tyr Gly Asp Asp Val Ile Ala Ser Tyr Pro 
                325                 330                 335     


Trp Pro Ile Asp Ala Ser Leu Leu Ala Glu Ala Gly Lys Asp Tyr Gly 
            340                 345                 350         


Leu Ile Met Thr Pro Ala Asp Lys Gly Glu Cys Phe Asn Glu Val Thr 
        355                 360                 365             


Trp Thr Asn Val Thr Phe Leu Lys Arg Tyr Phe Arg Ala Asp Glu Gln 
    370                 375                 380                 


Tyr Pro Phe Leu Val His Pro Val Met Pro Met Lys Asp Ile His Glu 
385                 390                 395                 400 


Ser Ile Arg Trp Thr Lys Asp Pro Lys Asn Thr Gln Asp His Val Arg 
                405                 410                 415     


Ser Leu Cys Leu Leu Ala Trp His Asn Gly Glu His Glu Tyr Glu Glu 
            420                 425                 430         


Phe Ile Arg Lys Ile Arg Ser Val Pro Val Gly Arg Cys Leu Thr Leu 
        435                 440                 445             


Pro Ala Phe Ser Thr Leu Arg Arg Lys Trp Leu Asp Ser Phe 
    450                 455                 460         


<210>  19
<211>  461
<212>  PRT
<213>  Enterovirus C

<400>  19

Gly Glu Ile Gln Trp Met Arg Pro Ser Lys Glu Val Gly Tyr Pro Ile 
1               5                   10                  15      


Ile Asn Ala Pro Ser Lys Thr Lys Leu Glu Pro Ser Ala Phe His Tyr 
            20                  25                  30          


Ile Phe Glu Gly Val Lys Glu Pro Ala Val Leu Thr Lys Asn Asp Pro 
        35                  40                  45              


Arg Leu Lys Thr Asp Phe Glu Glu Ala Ile Phe Ser Lys Tyr Val Gly 
    50                  55                  60                  


Asn Lys Ile Thr Glu Val Asp Glu Tyr Met Lys Glu Ala Val Asp His 
65                  70                  75                  80  


Tyr Ala Gly Gln Leu Met Ser Leu Asp Ile Asn Thr Glu Gln Met Cys 
                85                  90                  95      


Leu Glu Asp Ala Met Tyr Gly Thr Asp Gly Leu Glu Ala Leu Asp Leu 
            100                 105                 110         


Ser Thr Ser Ala Gly Tyr Pro Tyr Val Ala Leu Gly Lys Lys Lys Arg 
        115                 120                 125             


Asp Ile Leu Asn Lys Gln Thr Arg Asp Thr Lys Glu Met Gln Lys Leu 
    130                 135                 140                 


Leu Asp Thr Tyr Gly Ile Asn Leu Pro Leu Val Thr Tyr Val Lys Asp 
145                 150                 155                 160 


Glu Leu Arg Ser Lys Thr Lys Val Glu Gln Gly Lys Ser Arg Leu Ile 
                165                 170                 175     


Glu Ala Ser Ser Leu Asn Asp Ser Val Ala Met Arg Met Ala Phe Gly 
            180                 185                 190         


His Leu Tyr Ala Ala Phe His Lys Asn Pro Gly Val Val Thr Gly Ser 
        195                 200                 205             


Ala Val Gly Cys Asp Pro Asp Leu Phe Trp Ser Lys Ile Pro Val Leu 
    210                 215                 220                 


Met Glu Glu Lys Leu Phe Ala Phe Asp Tyr Thr Gly Tyr Asp Ala Ser 
225                 230                 235                 240 


Leu Ser Pro Ala Trp Phe Glu Ala Leu Lys Met Val Leu Glu Lys Ile 
                245                 250                 255     


Gly Phe Gly Asp Arg Val Asp Tyr Ile Asp Tyr Leu Asn His Ser His 
            260                 265                 270         


His Leu Tyr Lys Asn Lys Thr Tyr Cys Val Lys Gly Gly Met Pro Ser 
        275                 280                 285             


Gly Cys Ser Gly Thr Ser Ile Phe Asn Ser Met Ile Asn Asn Leu Ile 
    290                 295                 300                 


Ile Arg Thr Leu Leu Leu Lys Thr Tyr Lys Gly Ile Asp Leu Asp His 
305                 310                 315                 320 


Leu Lys Met Ile Ala Tyr Gly Asp Asp Val Ile Ala Ser Tyr Pro His 
                325                 330                 335     


Glu Val Asp Ala Ser Leu Leu Ala Gln Ser Gly Lys Asp Tyr Gly Leu 
            340                 345                 350         


Thr Met Thr Pro Ala Asp Lys Ser Ala Thr Phe Glu Thr Val Thr Trp 
        355                 360                 365             


Glu Asn Val Thr Phe Leu Lys Arg Phe Phe Arg Ala Asp Glu Lys Tyr 
    370                 375                 380                 


Pro Phe Leu Ile His Pro Val Met Pro Met Lys Glu Ile His Glu Ser 
385                 390                 395                 400 


Ile Arg Trp Thr Lys Asp Pro Arg Asn Thr Gln Asp His Val Arg Ser 
                405                 410                 415     


Leu Cys Leu Leu Ala Trp His Asn Gly Glu Glu Glu Tyr Asn Lys Phe 
            420                 425                 430         


Leu Ala Lys Ile Arg Ser Val Pro Ile Gly Arg Ala Leu Leu Leu Pro 
        435                 440                 445             


Glu Tyr Ser Thr Leu Tyr Arg Arg Trp Leu Asp Ser Phe 
    450                 455                 460     


<210>  20
<211>  461
<212>  PRT
<213>  Coxsackievirus A1

<400>  20

Gly Glu Ile Gln Trp Met Arg Pro Ser Lys Asp Ala Gly Tyr Pro Met 
1               5                   10                  15      


Ile Asn Ala Pro Ser Lys Thr Lys Leu Glu Pro Ser Val Phe Phe Asp 
            20                  25                  30          


Val Phe Pro Gly Glu Lys Glu Pro Ala Val Leu Thr Lys Asn Asp Pro 
        35                  40                  45              


Arg Leu Lys Val Asp Phe Glu Glu Ala Val Phe Ser Lys Tyr Ile Gly 
    50                  55                  60                  


Asn Lys Ile Thr Glu Val Asp Glu Tyr Met Lys Glu Ala Val Asp His 
65                  70                  75                  80  


Tyr Ala Gly Gln Leu Met Ser Leu Asp Ile Pro Thr Glu Gln Met Cys 
                85                  90                  95      


Leu Glu Asp Ala Met Tyr Gly Thr Asp Gly Leu Glu Ala Leu Asp Leu 
            100                 105                 110         


Thr Thr Ser Ala Gly Tyr Pro Tyr Val Ala Ile Gly Lys Lys Lys Arg 
        115                 120                 125             


Asp Ile Leu Asn Lys Gln Thr Arg Asp Thr Lys Glu Met Gln Lys Met 
    130                 135                 140                 


Leu Asp Lys Tyr Gly Ile Asn Leu Pro Leu Val Thr Tyr Val Lys Asp 
145                 150                 155                 160 


Glu Leu Arg Ser Lys Ser Lys Val Glu Gln Gly Lys Ser Arg Leu Ile 
                165                 170                 175     


Glu Ala Ser Ser Leu Asn Asp Ser Val Ala Met Arg Gln Ala Phe Gly 
            180                 185                 190         


His Leu Tyr Ala Lys Phe His Gln Asn Pro Gly Ile Ile Thr Gly Ser 
        195                 200                 205             


Ala Val Gly Cys Asp Pro Asp Val Phe Trp Ser Lys Val Pro Val Met 
    210                 215                 220                 


Leu Asn Gly Glu Leu Phe Ala Phe Asp Tyr Thr Gly Tyr Asp Ala Ser 
225                 230                 235                 240 


Leu Ser Pro Ala Trp Phe Glu Ala Leu Lys Met Val Leu Glu Lys Ile 
                245                 250                 255     


Gly Phe Gly Asp Arg Val Asp Phe Ile Asp Tyr Leu Asn His Ser His 
            260                 265                 270         


His Leu Tyr Arg Asn Lys Leu Tyr Cys Val Lys Gly Gly Met Pro Ser 
        275                 280                 285             


Gly Cys Ser Gly Thr Ser Ile Phe Asn Ser Met Ile Asn Asn Leu Ile 
    290                 295                 300                 


Ile Arg Thr Leu Met Leu Lys Thr Tyr Lys Gly Val Asp Leu Asp Ser 
305                 310                 315                 320 


Leu Arg Met Ile Ala Tyr Gly Asp Asp Val Ile Ala Ser Tyr Pro His 
                325                 330                 335     


Lys Ile Asp Ala Gly Leu Leu Ala Gln Ala Gly Lys Asp Tyr Gly Leu 
            340                 345                 350         


Val Met Thr Pro Ala Asp Lys Gly Ala Thr Phe Thr Asp Val Asp Trp 
        355                 360                 365             


Ser Asn Val Thr Phe Leu Lys Arg Phe Phe Arg Ala Asp Glu Gln Tyr 
    370                 375                 380                 


Pro Phe Leu Val His Pro Val Met Pro Met Lys Asp Ile Tyr Glu Ser 
385                 390                 395                 400 


Ile Arg Trp Thr Lys Asp Pro Arg Asn Thr Gln Asp His Val Arg Ser 
                405                 410                 415     


Leu Cys Leu Leu Ala Trp His Asn Gly Glu Glu Thr Tyr Asn Lys Phe 
            420                 425                 430         


Leu Ala Gln Ile Arg Ser Val Pro Val Gly Arg Ala Leu Leu Leu Pro 
        435                 440                 445             


Glu Tyr Ser Thr Leu Arg Arg Arg Trp Leu Asp Ser Phe 
    450                 455                 460     


<210>  21
<211>  457
<212>  PRT
<213>  Enterovirus 68

<400>  21

Gly Glu Ile Val Ser Asn Glu Lys Ser Gly Met Cys Ile Asn Ala Pro 
1               5                   10                  15      


Ala Lys Thr Lys Leu Gln Pro Ser Val Phe His Gln Val Phe Glu Gly 
            20                  25                  30          


Ser Lys Glu Pro Ala Val Leu Asn Ser Lys Asp Pro Arg Leu Lys Thr 
        35                  40                  45              


Asp Phe Glu Glu Ala Ile Phe Ser Lys Tyr Thr Gly Asn Lys Ile Met 
    50                  55                  60                  


Leu Met Asp Glu Tyr Met Glu Glu Ala Val Asp His Tyr Val Gly Cys 
65                  70                  75                  80  


Leu Glu Pro Leu Asp Ile Ser Val Asp Pro Ile Pro Leu Glu Asn Ala 
                85                  90                  95      


Met Tyr Gly Met Glu Gly Leu Glu Ala Leu Asp Leu Thr Thr Ser Ala 
            100                 105                 110         


Gly Phe Pro Tyr Leu Leu Gln Gly Lys Lys Lys Arg Asp Ile Phe Asn 
        115                 120                 125             


Arg Gln Thr Arg Asp Thr Ser Glu Met Thr Lys Met Leu Glu Lys Tyr 
    130                 135                 140                 


Gly Val Asp Leu Pro Phe Val Thr Phe Val Lys Asp Glu Leu Arg Ser 
145                 150                 155                 160 


Arg Glu Lys Val Glu Lys Gly Lys Ser Arg Leu Ile Glu Ala Ser Ser 
                165                 170                 175     


Leu Asn Asp Ser Val Ala Met Arg Val Ala Phe Gly Asn Leu Tyr Ala 
            180                 185                 190         


Thr Phe His Asn Asn Pro Gly Thr Ala Thr Gly Ser Ala Val Gly Cys 
        195                 200                 205             


Asp Pro Asp Ile Phe Trp Ser Lys Ile Pro Ile Leu Leu Asp Gly Glu 
    210                 215                 220                 


Ile Phe Ala Phe Asp Tyr Thr Gly Tyr Asp Ala Ser Leu Ser Pro Val 
225                 230                 235                 240 


Trp Phe Ala Cys Leu Lys Lys Val Leu Ile Lys Leu Gly Tyr Thr His 
                245                 250                 255     


Gln Thr Ser Phe Ile Asp Tyr Leu Cys His Ser Val His Leu Tyr Lys 
            260                 265                 270         


Asp Arg Lys Tyr Val Ile Asn Gly Gly Met Pro Ser Gly Ser Ser Gly 
        275                 280                 285             


Thr Ser Ile Phe Asn Thr Met Ile Asn Asn Ile Ile Ile Arg Thr Leu 
    290                 295                 300                 


Leu Ile Lys Val Tyr Lys Gly Ile Asp Leu Asp Gln Phe Lys Met Ile 
305                 310                 315                 320 


Ala Tyr Gly Asp Asp Val Ile Ala Ser Tyr Pro His Lys Ile Asp Pro 
                325                 330                 335     


Gly Leu Leu Ala Glu Ala Gly Lys His Tyr Gly Leu Val Met Thr Pro 
            340                 345                 350         


Ala Asp Lys Gly Thr Ser Phe Ile Asp Thr Asn Trp Glu Asn Val Thr 
        355                 360                 365             


Phe Leu Lys Arg Tyr Phe Arg Ala Asp Asp Gln Tyr Pro Phe Leu Ile 
    370                 375                 380                 


His Pro Val Met Pro Met Lys Glu Ile His Glu Ser Ile Arg Trp Thr 
385                 390                 395                 400 


Lys Asp Pro Arg Asn Thr Gln Asp His Val Arg Ser Leu Cys Tyr Leu 
                405                 410                 415     


Ala Trp His Asn Gly Glu Glu Ala Tyr Asn Glu Phe Cys Arg Lys Ile 
            420                 425                 430         


Arg Ser Val Pro Val Gly Arg Ala Leu Thr Leu Pro Ala Tyr Ser Ser 
        435                 440                 445             


Leu Arg Arg Lys Trp Leu Asp Ser Phe 
    450                 455         


<210>  22
<211>  457
<212>  PRT
<213>  Enterovirus 94

<400>  22

Gly Glu Ile Val Ser Val Glu Lys Ser Gly Val Phe Val Asn Ala Pro 
1               5                   10                  15      


Ala Lys Thr Lys Leu Glu Pro Ser Val Phe His Asp Val Phe Glu Gly 
            20                  25                  30          


Val Lys Glu Pro Ala Val Leu His Ser Lys Asp Lys Arg Leu Lys Val 
        35                  40                  45              


Asp Phe Glu Glu Ala Ile Phe Ser Lys Tyr Val Gly Asn Lys Thr Met 
    50                  55                  60                  


Leu Met Asp Glu Tyr Met Glu Glu Ala Val Asp His Tyr Val Gly Cys 
65                  70                  75                  80  


Leu Glu Pro Leu Asp Ile Ser Thr Glu Pro Ile Pro Leu Glu Ser Ala 
                85                  90                  95      


Met Tyr Gly Met Asp Gly Leu Glu Ala Leu Asp Leu Thr Thr Ser Ala 
            100                 105                 110         


Gly Tyr Pro Tyr Ile Leu Gln Gly Lys Lys Lys Arg Asp Ile Phe Asn 
        115                 120                 125             


Arg Gln Thr Arg Asp Thr Thr Glu Met Thr Lys Met Leu Asp Lys Tyr 
    130                 135                 140                 


Gly Val Asp Leu Pro Phe Val Thr Phe Val Lys Asp Glu Leu Arg Ser 
145                 150                 155                 160 


Arg Glu Lys Val Glu Lys Gly Lys Ser Arg Leu Ile Glu Ala Ser Ser 
                165                 170                 175     


Leu Asn Asp Ser Val Ala Met Arg Val Ala Phe Gly Asn Leu Tyr Ala 
            180                 185                 190         


Thr Phe His Lys Asn Pro Gly Val Ala Thr Gly Ser Ala Val Gly Cys 
        195                 200                 205             


Asp Pro Asp Ile Phe Trp Ser Lys Ile Pro Val Met Leu Asp Gly Lys 
    210                 215                 220                 


Val Phe Ala Phe Asp Tyr Thr Gly Tyr Asp Ala Ser Leu Ser Pro Val 
225                 230                 235                 240 


Trp Phe Ala Cys Leu Lys Lys Val Leu Ile Lys Leu Gly Tyr Thr His 
                245                 250                 255     


Gln Thr Ala Phe Ile Asp Tyr Leu Cys His Ser Val His Leu Tyr Lys 
            260                 265                 270         


Asp Arg Lys Tyr Ile Val Ser Gly Gly Met Pro Ser Gly Ser Ser Gly 
        275                 280                 285             


Thr Ser Ile Phe Asn Thr Met Ile Asn Asn Ile Ile Ile Arg Thr Leu 
    290                 295                 300                 


Leu Leu Lys Val Tyr Lys Gly Ile Asp Leu Asp Gln Phe Lys Met Ile 
305                 310                 315                 320 


Ala Tyr Gly Asp Asp Val Ile Ala Ser Tyr Pro His Glu Ile Asp Pro 
                325                 330                 335     


Gly Leu Leu Ala Lys Ala Gly Lys Glu Tyr Gly Leu Thr Met Thr Pro 
            340                 345                 350         


Ala Asp Lys Ser Ala Ser Phe Thr Asp Thr Thr Trp Glu Asn Val Thr 
        355                 360                 365             


Phe Leu Lys Arg Tyr Phe Arg Ala Asp Asp Gln Tyr Pro Phe Leu Ile 
    370                 375                 380                 


His Pro Val Met Pro Met Lys Glu Ile His Glu Ser Ile Arg Trp Thr 
385                 390                 395                 400 


Lys Asp Pro Arg Asn Thr Gln Asp His Val Arg Ser Leu Cys Leu Leu 
                405                 410                 415     


Ala Trp His Asn Gly Glu Glu Ala Tyr Asn Glu Phe Cys Lys Lys Ile 
            420                 425                 430         


Arg Ser Val Pro Val Gly Arg Ala Leu Ala Leu Pro Val Tyr Ser Ser 
        435                 440                 445             


Leu Arg Arg Lys Trp Leu Asp Ser Phe 
    450                 455         


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial linker

<400>  23

Gly Gly Gly Gly Ser 
1               5   


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial linker

<400>  24

Thr Pro Leu Gly Asp Thr Thr His Thr Ser Gly 
1               5                   10      
