
                                SEQUENCE LISTING

<110> Juno Therapeutics, Inc.

<120> ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS SPECIFIC FOR ROR1

<130> 735042001740

<140> Not Yet Assigned    
<141> Concurrently Herewith             

<150> US 62/104,664       
<151> 2015-01-16  

<160> 318

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 720
<212> DNA
<213> Homo sapiens

<220> 
<223> Clone 83 scFv

<400> 1
caggtccagc ttgtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60
tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgacaggcc 120
cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac 180
gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240
atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagatagc 300
agctatgatg cttttgatat ctggggccaa gggacaatgg tcaccgtctc ctcaggtgga 360
ggcggttcag gcggaggtgg ctctggcggt ggcggatcgg ccatccagtt gacccaatct 420
ccttccaccc tgtctgcatc tgtaggagac agagtcacca tcacttgcca ggcgagtcag 480
gacatcagca attatttaaa ttggtatcag cagaaaccag ggaaagcccc taaactcctg 540
atcaacgatg catcctattt ggagacaggg gtcccatcaa ggttcagtgg aagtggatct 600
gggacagatt ttactttaac catcagcagc ctgcagcctg aagatattgc aacatattac 660
tgtcaacagt atgaaagtct cccgtacact tttggccagg ggaccaagct ggagatcaaa 720


<210> 2
<211> 240
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 83 scFv

<400> 2
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Ser Ser Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr
            100                 105                 110         
Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        115                 120                 125             
Gly Gly Gly Gly Ser Ala Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu
    130                 135                 140                 
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln
145                 150                 155                 160 
Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala
                165                 170                 175     
Pro Lys Leu Leu Ile Asn Asp Ala Ser Tyr Leu Glu Thr Gly Val Pro
            180                 185                 190         
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
        195                 200                 205             
Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr
    210                 215                 220                 
Glu Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
225                 230                 235                 240 


<210> 3
<211> 726
<212> DNA
<213> Homo sapiens

<220> 
<223> Clone 298 scFv

<400> 3
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc cagggcggtc cctgagactc 60
tcctgtacag cttctggatt cacctttggt gattatgcga tgagctgggt ccgccaggct 120
ccagggaagg ggctggagtg ggtctcaagt attagtggta gtggtcgtag cacagaccac 180
gcagactacg tgaagggccg gttcaccatc tccagagaca attccaagaa cacggtatat 240
ctgcaaatga acaggctgag agccgaggac acggccgtgt attactgtgc aaaagtcagt 300
aactacgagt attactttga ctactgggcc cagggaaccc tggtcaccgt ctcctcaggt 360
ggaggcggtt caggcggagg tggctctggc ggtggcggat cggaaattgt gctgactcag 420
tctccctcgg tgtcagtggc cccaggacag acggccagaa ttacctgtgg gggaagcaac 480
attggatctg agagtgtcaa ctggtaccag tggaagtcgg gccaggttcc tgtcttggtc 540
gtctctgaca ctaccgaccg accctcaggg atccctgggc gattcactgg cacccggtct 600
gggaccacgg ccaccttgac catcagtggg gtcgaagccg gggatgaggc cgactatcac 660
tgtcaggtgt gggatgacac tggtgatcat cctgtcttcg gcggagggac caagctgacc 720
gtccta                                                            726

<210> 4
<211> 242
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 298 scFv

<400> 4
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Arg Ser Thr Asp His Ala Asp Tyr Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr
65                  70                  75                  80  
Leu Gln Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Val Ser Asn Tyr Glu Tyr Tyr Phe Asp Tyr Trp Ala Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ser Val
    130                 135                 140                 
Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly Gly Ser Asn
145                 150                 155                 160 
Ile Gly Ser Glu Ser Val Asn Trp Tyr Gln Trp Lys Ser Gly Gln Val
                165                 170                 175     
Pro Val Leu Val Val Ser Asp Thr Thr Asp Arg Pro Ser Gly Ile Pro
            180                 185                 190         
Gly Arg Phe Thr Gly Thr Arg Ser Gly Thr Thr Ala Thr Leu Thr Ile
        195                 200                 205             
Ser Gly Val Glu Ala Gly Asp Glu Ala Asp Tyr His Cys Gln Val Trp
    210                 215                 220                 
Asp Asp Thr Gly Asp His Pro Val Phe Gly Gly Gly Thr Lys Leu Thr
225                 230                 235                 240 
Val Leu
        

<210> 5
<211> 741
<212> DNA
<213> Homo sapiens

<220> 
<223> Clone 48 scFv

<400> 5
caggtcacct tgaaggagtc tgggggaggc ttggtaaagc ctggggggtc ccttagactc 60
tcctgtgcag cctctggatt cactttcagt aacgcctgga tgagctgggt ccgccaggct 120
ccagggaagg ggctggagtg ggttggccgt attaaaagca aaactgatgg tgggacaaca 180
gactacgctg cacccgtgaa aggcagattc accatctcaa gagatgattc aaaaaacacg 240
ctgtatctgc aaatgaacag cctgaaaacc gaggacacag ccgtgtatta ctgtgcgaga 300
gatttcggac gatggagcta ctactttgac tactggagcc agggaaccct ggtcaccgtc 360
tcctcaggtg gaggcggttc aggcggaggt ggctctggcg gtggcggatc gcagtctgtg 420
ctgactcagc catcctcagt gtctgggacc cccgggcaga gggtcaccat ctcttgttct 480
ggaagcagct ccaacatcgg aagtaattat gtatactggt accagcagct cccaggaacg 540
gcccccaaac tcctcatcta taggaataat cagcggccct caggggtccc tgaccgattc 600
tctggctcca agtctggcac ctcagcctcc ctggccatca gtgggctccg gtccgaggat 660
gaggctgatt attactgtgc agcatgggat gacagcctga gtggtgtggt attcggcgga 720
gggaccaagc tcaccgtcct a                                           741

<210> 6
<211> 247
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 48 scFv

<400> 6
Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro
    130                 135                 140                 
Ser Ser Val Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser
145                 150                 155                 160 
Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr Trp Tyr Gln Gln
                165                 170                 175     
Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Arg Asn Asn Gln Arg
            180                 185                 190         
Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser
        195                 200                 205             
Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr
    210                 215                 220                 
Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Val Val Phe Gly Gly
225                 230                 235                 240 
Gly Thr Lys Leu Thr Val Leu
                245         


<210> 7
<211> 357
<212> DNA
<213> Homo sapiens

<220> 
<223> Clone V70 VH

<400> 7
caggtgcagc tgttggagtc tgggggaggc ttggtacagc cagggcggtc cctgagactc 60
tcctgtacag cttctggatt cacctttggt gattatgcga tgagctgggt ccgccaggct 120
ccagggaagg ggctggagtg ggtctcaagt attagtggta gtggtcgtag cacagaccac 180
gcagactacg tgaagggccg gttcaccatc tccagagaca attccaagaa cacggtatat 240
ctgcaaatga acaggctgag agccgaggac acggccgtgt attactgtgc aaaagtcagt 300
aactacgagt attactttga ctactgggcc cagggaaccc tggtcaccgt ctcctca    357

<210> 8
<211> 119
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V70 VH

<400> 8
Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Arg Ser Thr Asp His Ala Asp Tyr Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr
65                  70                  75                  80  
Leu Gln Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Val Ser Asn Tyr Glu Tyr Tyr Phe Asp Tyr Trp Ala Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 9
<211> 366
<212> DNA
<213> Homo sapiens

<220> 
<223> Clone V353 VH

<400> 9
caggtcacct tgaaggagtc tgggggaggc ttggtaaagc ctggggggtc ccttagactc 60
tcctgtgcag cctctggatt cactttcagt aacgcctgga tgagctgggt ccgccaggct 120
ccagggaagg ggctggagtg ggttggccgt attaaaagca aaactgatgg tgggacaaca 180
gactacgctg cacccgtgaa aggcagattc accatctcaa gagatgattc aaaaaacacg 240
ctgtatctgc aaatgaacag cctgaaaacc gaggacacag ccgtgtatta ctgtgcgaga 300
gatttcggac gatggggcta ctactttgac tactggagcc agggaaccct ggtcaccgtc 360
tcctca                                                            366

<210> 10
<211> 122
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V353 VH

<400> 10
Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Gly Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Ser Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 11
<211> 720
<212> DNA
<213> Homo sapiens

<220> 
<223> Clone 83B scFv

<400> 11
caggtccagc ttgtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60
tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgacaggcc 120
cctggacaag ggcttgagtg gatgggaata atcaacccta atggtggtag cacaagctac 180
gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240
atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagatagc 300
agctatgatg cttttgatat ctggggccaa gggacaatgg tcaccgtctc ctcaggtgga 360
ggcggttcag gcggaggtgg ctctggcggt ggcggatcgg ccatccagtt gacccaatct 420
ccttccaccc tgtctgcatc tgtaggagac agagtcacca tcacttgcca ggcgagtcag 480
gacatcagca attatttaaa ttggtatcag cagaaaccag ggaaagcccc taaactcctg 540
atcaacgatg catcctattt ggagacaggg gtcccatcaa ggttcagtgg aagtggatct 600
gggacagatt ttactttaac catcagcagc ctgcagcctg aagatattgc aacatattac 660
tgtcaacagt atgaaagtct cccgtacact tttggccagg ggaccaagct ggagatcaaa 720


<210> 12
<211> 240
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 83B scFv

<400> 12
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Asn Pro Asn Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Ser Ser Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr
            100                 105                 110         
Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        115                 120                 125             
Gly Gly Gly Gly Ser Ala Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu
    130                 135                 140                 
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln
145                 150                 155                 160 
Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala
                165                 170                 175     
Pro Lys Leu Leu Ile Asn Asp Ala Ser Tyr Leu Glu Thr Gly Val Pro
            180                 185                 190         
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
        195                 200                 205             
Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr
    210                 215                 220                 
Glu Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
225                 230                 235                 240 


<210> 13
<211> 122
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 48 VH

<400> 13
Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Ser Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 14
<211> 110
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 48 VL

<400> 14
Gln Ser Val Leu Thr Gln Pro Ser Ser Val Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
            20                  25                  30          
Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
                85                  90                  95      
Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110 


<210> 15
<211> 119
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 298 VH

<400> 15
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Arg Ser Thr Asp His Ala Asp Tyr Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr
65                  70                  75                  80  
Leu Gln Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Val Ser Asn Tyr Glu Tyr Tyr Phe Asp Tyr Trp Ala Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 16
<211> 108
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 298 VL

<400> 16
Glu Ile Val Leu Thr Gln Ser Pro Ser Val Ser Val Ala Pro Gly Gln
 1               5                  10                  15      
Thr Ala Arg Ile Thr Cys Gly Gly Ser Asn Ile Gly Ser Glu Ser Val
            20                  25                  30          
Asn Trp Tyr Gln Trp Lys Ser Gly Gln Val Pro Val Leu Val Val Ser
        35                  40                  45              
Asp Thr Thr Asp Arg Pro Ser Gly Ile Pro Gly Arg Phe Thr Gly Thr
    50                  55                  60                  
Arg Ser Gly Thr Thr Ala Thr Leu Thr Ile Ser Gly Val Glu Ala Gly
65                  70                  75                  80  
Asp Glu Ala Asp Tyr His Cys Gln Val Trp Asp Asp Thr Gly Asp His
                85                  90                  95      
Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105             


<210> 17
<211> 118
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 83 VH

<400> 17
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Ser Ser Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr
            100                 105                 110         
Met Val Thr Val Ser Ser
        115             


<210> 18
<211> 107
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 83, 83B VL

<400> 18
Ala Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Asn Asp Ala Ser Tyr Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Glu Ser Leu Pro Tyr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 19
<211> 118
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 83B VH

<400> 19
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Asn Pro Asn Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Ser Ser Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr
            100                 105                 110         
Met Val Thr Val Ser Ser
        115             


<210> 20
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 83, 83B CDR-H1

<400> 20
Ser Tyr Tyr Met His
 1               5  


<210> 21
<211> 17
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 83 CDR-H2

<400> 21
Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln
 1               5                  10                  15      
Gly
    

<210> 22
<211> 9
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 83, 83B CDR-H3

<400> 22
Asp Ser Ser Tyr Asp Ala Phe Asp Ile
 1               5                  


<210> 23
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 83, 83B CDR-L1

<400> 23
Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn
 1               5                  10      


<210> 24
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 83, 83B CDR-L2

<400> 24
Asp Ala Ser Tyr Leu Glu Thr
 1               5          


<210> 25
<211> 9
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 83, 83B CDR-L3

<400> 25
Gln Gln Tyr Glu Ser Leu Pro Tyr Thr
 1               5                  


<210> 26
<211> 17
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 83B CDR-H2

<400> 26
Ile Ile Asn Pro Asn Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln
 1               5                  10                  15      
Gly
    

<210> 27
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 298, V70 CDR-H1

<400> 27
Asp Tyr Ala Met Ser
 1               5  


<210> 28
<211> 17
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 298, V70 CDR-H2

<400> 28
Ser Ile Ser Gly Ser Gly Arg Ser Thr Asp His Ala Asp Tyr Val Lys
 1               5                  10                  15      
Gly
    

<210> 29
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 298, 305, 350, 366, V70 CDR-H3

<400> 29
Val Ser Asn Tyr Glu Tyr Tyr Phe Asp Tyr
 1               5                  10  


<210> 30
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 298 CDR-L1

<400> 30
Gly Gly Ser Asn Ile Gly Ser Glu Ser Val Asn
 1               5                  10      


<210> 31
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 298 CDR-L2

<400> 31
Asp Thr Thr Asp Arg Pro Ser
 1               5          


<210> 32
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 298 CDR-L3

<400> 32
Gln Val Trp Asp Asp Thr Gly Asp His Pro Val
 1               5                  10      


<210> 33
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 48, V353 CDR-H1

<400> 33
Asn Ala Trp Met Ser
 1               5  


<210> 34
<211> 19
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 48, V353 CDR-H2

<400> 34
Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala Pro
 1               5                  10                  15      
Val Lys Gly
            

<210> 35
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Clones 16, 20, 43, 48, 40, 65, 81, 7, V128, V18 CDR-H3

<400> 35
Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr
 1               5                  10      


<210> 36
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 48 CDR-L1

<400> 36
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr
 1               5                  10              


<210> 37
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 48 CDR-L2

<400> 37
Arg Asn Asn Gln Arg Pro Ser
 1               5          


<210> 38
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Clones 43, 48 CDR-L3

<400> 38
Ala Ala Trp Asp Asp Ser Leu Ser Gly Val Val
 1               5                  10      


<210> 39
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 305 CDR-L3

<400> 39
Gln Val Trp Asp Asn Asp Ser Asp His Arg Val
 1               5                  10      


<210> 40
<211> 9
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 350 CDR-L3

<400> 40
Gln Ser Tyr Asp Ser Ser Asn His Val
 1               5                  


<210> 41
<211> 9
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 20 CDR-L3

<400> 41
Gln Gln Leu Lys Ser Arg Pro Leu Ser
 1               5                  


<210> 42
<211> 9
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 16 CDR-L3

<400> 42
Gln Gln Leu Asn Ser Tyr Pro Leu Thr
 1               5                  


<210> 43
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 366 CDR-L3

<400> 43
Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val
 1               5                  10      


<210> 44
<211> 9
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 40 CDR-L3

<400> 44
Gln Ser Tyr Asp Gly Arg Asn Leu Met
 1               5                  


<210> 45
<211> 14
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 461 CDR-H3

<400> 45
Asp Phe Glu Val Arg Glu Ala His Leu Ser Tyr Phe Asp Tyr
 1               5                  10                  


<210> 46
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 461 CDR-L3

<400> 46
Gln Val Trp Asp Ser Ser Ser Asp His Arg Val
 1               5                  10      


<210> 47
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 65 CDR-L3

<400> 47
Lys Ser Trp Asp Ser Ser Gly Ser Leu Tyr Val
 1               5                  10      


<210> 48
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 81 CDR-L3

<400> 48
Gln Val Trp Asp Ser Ser Ser Asp His Tyr Val
 1               5                  10      


<210> 49
<211> 9
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 7 CDR-L3 

<400> 49
Gln Ala Trp Asp Ser Ser Thr Val Val
 1               5                  


<210> 50
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V420 CDR-H3

<400> 50
Val Asn Gly Gly Glu Tyr Tyr Phe Asp Tyr
 1               5                  10  


<210> 51
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V282 CDR-H3

<400> 51
Val Arg Gly Ser Glu Tyr Tyr Phe Asp Tyr
 1               5                  10  


<210> 52
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V353 CDR-H3

<400> 52
Asp Phe Gly Arg Trp Gly Tyr Tyr Phe Asp Tyr
 1               5                  10      


<210> 53
<211> 16
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V163 CDR-H3

<400> 53
Gln Gly Asp Ser Ser Ser Trp Tyr Val Glu Val Tyr Tyr Phe Asp Tyr
 1               5                  10                  15      


<210> 54
<211> 9
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V355 CDR-H3

<400> 54
Ile Thr Pro Pro Asp Ala Phe Asp Ile
 1               5                  


<210> 55
<211> 14
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V224 CDR-H3

<400> 55
Thr Tyr Ser Ser Ser Trp Tyr Glu Ser Leu Leu Phe Asp Tyr
 1               5                  10                  


<210> 56
<211> 15
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V95 CDR-H3

<400> 56
Gly Ser Gly Glu Leu Arg Phe Leu Glu Ser Tyr Tyr Phe Asp Tyr
 1               5                  10                  15  


<210> 57
<211> 14
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V316 CDR-H3

<400> 57
Val Asp Ser Glu Arg Phe Leu Glu Trp Tyr Tyr Phe Asp Tyr
 1               5                  10                  


<210> 58
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V331 CDR-H3

<400> 58
Gly Gln Ile Ala Ala His Val Trp Gly Trp Phe Asp Pro
 1               5                  10              


<210> 59
<211> 14
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V357 CDR-H3

<400> 59
Asp Met Val Gly Ala Trp Leu Val Leu Ser Tyr Phe Asp Tyr
 1               5                  10                  


<210> 60
<211> 14
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V397 CDR-H3

<400> 60
Ala Lys Gly Leu Trp Phe Gly Glu Ser Tyr Tyr Phe Asp Tyr
 1               5                  10                  


<210> 61
<211> 14
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V312 CDR-H3

<400> 61
Thr Ser Arg Gly Arg Phe Leu Glu Trp Leu Leu Phe Asp Tyr
 1               5                  10                  


<210> 62
<211> 12
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V278 CDR-H3

<400> 62
Glu Arg Ser Arg Trp Gly Asp Asn Trp Phe Asp Pro
 1               5                  10          


<210> 63
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V86 CDR-H3

<400> 63
Val Ile Phe Gly Val Val Asn Ile Pro Asp Tyr
 1               5                  10      


<210> 64
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V102 CDR-H3

<400> 64
Val Gly Pro Ser Trp Asp Tyr Tyr Phe Asp Tyr
 1               5                  10      


<210> 65
<211> 16
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V365 CDR-H3

<400> 65
Gly Ile Gly Tyr Ser Ser Ser Trp Tyr Glu Ile Trp Thr Phe Asp Tyr
 1               5                  10                  15      


<210> 66
<211> 14
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V181 CDR-H3

<400> 66
Asp Phe Glu Val Arg Glu Ala His Leu Ser Tyr Phe Asp Tyr
 1               5                  10                  


<210> 67
<211> 14
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V71 CDR-H3

<400> 67
Val Leu Arg Ser Gly Phe Leu Glu Trp Asn Leu Phe Asp Tyr
 1               5                  10                  


<210> 68
<211> 14
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V68 CDR-H3

<400> 68
Asp Phe Glu Val Arg Gly Ala His Leu Ser Tyr Phe Asp Tyr
 1               5                  10                  


<210> 69
<211> 14
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V336 CDR-H3

<400> 69
Val Tyr Gly Tyr Asp Tyr Arg Asp Phe Gly Trp Phe Asp Pro
 1               5                  10                  


<210> 70
<211> 14
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V9 CDR-H3

<400> 70
Gly Ser Asn Glu Arg Phe Leu Glu Trp Leu Asn Phe Asp Tyr
 1               5                  10                  


<210> 71
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V345 CDR-H3

<400> 71
Gly Pro Leu Arg Pro Gln Lys Val Leu Pro Phe Gln Ile
 1               5                  10              


<210> 72
<211> 12
<212> PRT
<213> Rabbit

<220> 
<223> R12 CDR-H3

<400> 72
Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile
 1               5                  10          


<210> 73
<211> 9
<212> PRT
<213> Rabbit

<220> 
<223> R12 CDR-L3

<400> 73
Gly Ala Asp Tyr Ile Gly Gly Tyr Val
 1               5                  


<210> 74
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 83, 83B CDR-H1

<400> 74
Gly Tyr Thr Phe Thr Ser
 1               5      


<210> 75
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 83, 83B CDR-H1

<400> 75
Gly Tyr Thr Phe Thr Ser Tyr Tyr Met His
 1               5                  10  


<210> 76
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 298, V70 CDR-H1

<400> 76
Gly Phe Thr Phe Gly Asp
 1               5      


<210> 77
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 298, V70 CDR-H1

<400> 77
Gly Phe Thr Phe Gly Asp Tyr Ala Met Ser
 1               5                  10  


<210> 78
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 48, V353 CDR-H1

<400> 78
Gly Phe Thr Phe Ser Asn
 1               5      


<210> 79
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 48, V353 CDR-H1

<400> 79
Gly Phe Thr Phe Ser Asn Ala Trp Met Ser
 1               5                  10  


<210> 80
<211> 8
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 83 CDR-H2

<400> 80
Ile Ile Asn Pro Ser Gly Gly Ser
 1               5              


<210> 81
<211> 8
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 298, V70 CDR-H2

<400> 81
Ser Ile Ser Gly Ser Gly Arg Ser
 1               5              


<210> 82
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 48, V353 CDR -H2

<400> 82
Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr
 1               5                  10  


<210> 83
<211> 8
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 83B CDR-H2

<400> 83
Ile Ile Asn Pro Asn Gly Gly Ser
 1               5              


<210> 84
<211> 248
<212> PRT
<213> Rabbit

<220> 
<223> R12 scFv

<400> 84
Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly
 1               5                  10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val
    50                  55                  60                  
Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys
                85                  90                  95      
Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly
            100                 105                 110         
Pro Gly Thr Leu Val Thr Ile Ser Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Leu Thr Gln Ser Pro
    130                 135                 140                 
Ser Val Ser Ala Ala Leu Gly Ser Pro Ala Lys Ile Thr Cys Thr Leu
145                 150                 155                 160 
Ser Ser Ala His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Gln
                165                 170                 175     
Gly Glu Ala Pro Arg Tyr Leu Met Gln Val Gln Ser Asp Gly Ser Tyr
            180                 185                 190         
Thr Lys Arg Pro Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly
        195                 200                 205             
Ala Asp Arg Tyr Leu Ile Ile Pro Ser Val Gln Ala Asp Asp Glu Ala
    210                 215                 220                 
Asp Tyr Tyr Cys Gly Ala Asp Tyr Ile Gly Gly Tyr Val Phe Gly Gly
225                 230                 235                 240 
Gly Thr Gln Leu Thr Val Thr Gly
                245             


<210> 85
<211> 121
<212> PRT
<213> Rabbit

<220> 
<223> R12 VH

<400> 85
Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly
 1               5                  10                  15      
Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val
    50                  55                  60                  
Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys
                85                  90                  95      
Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly
            100                 105                 110         
Pro Gly Thr Leu Val Thr Ile Ser Ser
        115                 120     


<210> 86
<211> 112
<212> PRT
<213> Rabbit

<220> 
<223> R12 VL

<400> 86
Glu Leu Val Leu Thr Gln Ser Pro Ser Val Ser Ala Ala Leu Gly Ser
 1               5                  10                  15      
Pro Ala Lys Ile Thr Cys Thr Leu Ser Ser Ala His Lys Thr Asp Thr
            20                  25                  30          
Ile Asp Trp Tyr Gln Gln Leu Gln Gly Glu Ala Pro Arg Tyr Leu Met
        35                  40                  45              
Gln Val Gln Ser Asp Gly Ser Tyr Thr Lys Arg Pro Gly Val Pro Asp
    50                  55                  60                  
Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ile Ile Pro
65                  70                  75                  80  
Ser Val Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Tyr
                85                  90                  95      
Ile Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly
            100                 105                 110         


<210> 87
<211> 5
<212> PRT
<213> Rabbit

<220> 
<223> R12 CDR-H1

<400> 87
Ala Tyr Tyr Met Ser
 1               5  


<210> 88
<211> 17
<212> PRT
<213> Rabbit

<220> 
<223> R12 CDR-H2

<400> 88
Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val Asn
 1               5                  10                  15      
Gly
    

<210> 89
<211> 12
<212> PRT
<213> Rabbit

<220> 
<223> R12 CDR-L1

<400> 89
Thr Leu Ser Ser Ala His Lys Thr Asp Thr Ile Asp
 1               5                  10          


<210> 90
<211> 7
<212> PRT
<213> Rabbit

<220> 
<223> R12 CDR-L2

<400> 90
Gly Ser Tyr Thr Lys Arg Pro
 1               5          


<210> 91
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic linker

<400> 91
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15  


<210> 92
<211> 16
<212> PRT
<213> Homo sapiens

<220> 
<223> Consensus CDR-H3

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = D, V, Q, I, T, G, A, or E

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = S, F, N, R, G, T, Y, D, Q, M, K, I, L, or P

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = S, N, G, E, D, P, I, V, R, F, N, or L

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Y, R, V, G, S, P, E, A, or L

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = D, E, W, R, S, L, A, V, G, or P

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = A, W, S, E, G, Y, R, F, H, V, D, S, or Q

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = F, Y, A, W, L, G, D, V, N, S, K, or R

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = F, Y, H, E, L, W, V, N, I, D, or null

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = F, L, V, S, E, W, G, P, Y, or null

<220> 
<221> VARIANT        
<222> 10
<223> Xaa = S, E, L, Y, W, F, N, G, P, or null

<220> 
<221> VARIANT        
<222> 11
<223> Xaa = Y, V, L, F, I, W, N, or null

<220> 
<221> VARIANT        
<222> 12
<223> Xaa = F, Y, W, or null

<220> 
<221> VARIANT        
<222> 13
<223> Xaa = Y, F, T, or null

<220> 
<221> VARIANT        
<222> 14
<223> Xaa = F or null

<220> 
<221> VARIANT        
<222> 15
<223> Xaa = D or Q

<220> 
<221> VARIANT        
<222> 16
<223> Xaa = I, Y, or P

<400> 92
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5                  10                  15      


<210> 93
<211> 14
<212> PRT
<213> Homo sapiens

<220> 
<223> Consensus CDR-H3

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = D or V

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = S or F

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = S, N, G, or E

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Y, R, or V

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = D, E, W, or R

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = A, Y, S, or E

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = F, Y, or A

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = F, Y, H, or null

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = F, L, or null

<220> 
<221> VARIANT        
<222> 10
<223> Xaa = S or null

<220> 
<221> VARIANT        
<222> 11
<223> Xaa = Y or null

<220> 
<221> VARIANT        
<222> 12	
<223> Xaa = F or null

<220> 
<221> VARIANT        
<222> 14
<223> Xaa = I or Y

<400> 93
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Xaa
 1               5                  10                  


<210> 94
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Consensus CDR-H3

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = V or D

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = S or F

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = N or G

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Y or R

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = E or W

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = Y or G

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = F or Y

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = F or null

<400> 94
Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Asp Tyr
 1               5                  10      


<210> 95
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<223> Consensus CDR-H1

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = S, D, or N

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = Y or A

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = Y, A, or W

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = H or S

<400> 95
Xaa Xaa Xaa Met Xaa
 1               5  


<210> 96
<211> 19
<212> PRT
<213> Homo sapiens

<220> 
<223> Consensus CDR-H2

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = I, S, or R

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = N, S, or K

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = P, G, or S

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = K or null

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = T or null

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = S, D, or N

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = G or R

<220> 
<221> VARIANT        
<222> 10
<223> Xaa = S or T

<220> 
<221> VARIANT        
<222> 12
<223> Xaa = S or D

<220> 
<221> VARIANT        
<222> 13
<223> Xaa = Y or H

<220> 
<221> VARIANT        
<222> 15
<223> Xaa = Q, D, or A

<220> 
<221> VARIANT        
<222> 16
<223> Xaa = K, Y, or P

<220> 
<221> VARIANT        
<222> 17
<223> Xaa = F or V

<220> 
<221> VARIANT        
<222> 18
<223> Xaa = Q or K

<400> 96
Xaa Ile Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Thr Xaa Xaa Ala Xaa Xaa
 1               5                  10                  15      
Xaa Xaa Gly
            

<210> 97
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<223> Consensus CDR-H1

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = D or N

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = Y or A

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = A or W

<400> 97
Xaa Xaa Xaa Met Ser
 1               5

<210> 98
<211> 19
<212> PRT
<213> Homo sapiens

<220> 
<223> Consensus CDR-H2

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = I, S, or R

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = N, S, or K

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = P, G, or S

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = K or null

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = T or null

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = S, D, or N

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = G or R

<220> 
<221> VARIANT        
<222> 10
<223> Xaa = S or T

<220> 
<221> VARIANT        
<222> 12
<223> Xaa = S or D

<220> 
<221> VARIANT        
<222> 13
<223> Xaa = Y or H

<220> 
<221> VARIANT        
<222> 15
<223> Xaa = Q, D, or A

<220> 
<221> VARIANT        
<222> 16
<223> Xaa = K, Y, or P

<220> 
<221> VARIANT        
<222> 17
<223> Xaa = F or V

<220> 
<221> VARIANT        
<222> 18
<223> Xaa = Q or K

<400> 98
Xaa Ile Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Thr Xaa Xaa Ala Xaa Xaa
 1               5                  10                  15      
Xaa Xaa Gly
            

<210> 99
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Consensus CDR-L3

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Q, A, or K

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = Q, V, A, or S

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = Y, W, or L

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = E, D, K, or N

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = S, D, N, or G

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = L, T, S, D, R, or Y

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = P, G, L, S, N, or T

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = D, S, N, or null

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = H, G, L, or null

<220> 
<221> VARIANT        
<222> 10
<223> Xaa = Y, P, V, R, H, or L

<220> 
<221> VARIANT        
<222> 11
<223> Xaa = T, V, S, or M

<400> 99
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5                  10                  


<210> 100
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Consensus CDR-L3

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Q or A

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = Q, V, or A

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = Y or W

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = E or D

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = S or D

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = L, T, or S

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = P, G, or L

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = D, S, or null

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = H, G, or null

<220> 
<221> VARIANT        
<222> 10
<223> Xaa = Y, P, or V

<220> 
<221> VARIANT        
<222> 11
<223> Xaa = T or V

<400> 100
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5                  10                  


<210> 101
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<223> Consensus CDR-L1

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Q, G, or S

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = A or G

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Q, N, or S

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = S or null

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = N or null

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = D or I

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = I or G

<220> 
<221> VARIANT        
<222> 10
<223> Xaa = N or E

<220> 
<221> VARIANT        
<222> 11
<223> Xaa = Y or S

<220> 
<221> VARIANT        
<222> 12
<223> Xaa = L or V

<220> 
<221> VARIANT        
<222> 13
<223> Xaa = N or Y

<400> 101
Xaa Xaa Ser Xaa Xaa Xaa Xaa Xaa Ser Xaa Xaa Xaa Xaa
 1               5                  10              


<210> 102
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> Consensus CDR-L2

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = D or R

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = A, T, or N

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = S, T, or N

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Y, D, or Q

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = L or R

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = E or P

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = T or S

<400> 102
Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5          


<210> 103
<211> 908
<212> PRT
<213> Homo sapiens

<220> 
<223> Human ROR1, GenBank No. NP_005003.2

<400> 103
Gln Glu Thr Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser
 1               5                  10                  15      
Trp Asn Ile Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp
            20                  25                  30          
Glu Pro Met Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu
        35                  40                  45              
His Cys Lys Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys
    50                  55                  60                  
Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser
65                  70                  75                  80  
Thr Ile Tyr Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp
                85                  90                  95      
Thr Gly Tyr Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser
            100                 105                 110         
Ser Thr Gly Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser
        115                 120                 125             
Pro Gly Tyr Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr
    130                 135                 140                 
Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met
145                 150                 155                 160 
Glu Ser Leu His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala
                165                 170                 175     
Phe Thr Met Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln
            180                 185                 190         
Phe Ala Ile Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu
        195                 200                 205             
Thr Ser Ser Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu
    210                 215                 220                 
Ile Leu Glu Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser
225                 230                 235                 240 
Asn Pro Met Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu
                245                 250                 255     
Pro Gln Pro Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile
            260                 265                 270         
Pro Met Ala Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr
        275                 280                 285             
Gly Val Asp Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln
    290                 295                 300                 
Cys Gln Pro Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala
305                 310                 315                 320 
Leu Arg Phe Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro
                325                 330                 335     
Gly Asn Gln Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe
            340                 345                 350         
Lys Ser Asp Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys
        355                 360                 365             
Glu Lys Asn Lys Met Glu Ile Leu Tyr Ile Leu Val Pro Ser Val Ala
    370                 375                 380                 
Ile Pro Leu Ala Ile Ala Leu Leu Phe Phe Phe Ile Cys Val Cys Arg
385                 390                 395                 400 
Asn Asn Gln Lys Ser Ser Ser Ala Pro Val Gln Arg Gln Pro Lys His
                405                 410                 415     
Val Arg Gly Gln Asn Val Glu Met Ser Met Leu Asn Ala Tyr Lys Pro
            420                 425                 430         
Lys Ser Lys Ala Lys Glu Leu Pro Leu Ser Ala Val Arg Phe Met Glu
        435                 440                 445             
Glu Leu Gly Glu Cys Ala Phe Gly Lys Ile Tyr Lys Gly His Leu Tyr
    450                 455                 460                 
Leu Pro Gly Met Asp His Ala Gln Leu Val Ala Ile Lys Thr Leu Lys
465                 470                 475                 480 
Asp Tyr Asn Asn Pro Gln Gln Trp Thr Glu Phe Gln Gln Glu Ala Ser
                485                 490                 495     
Leu Met Ala Glu Leu His His Pro Asn Ile Val Cys Leu Leu Gly Ala
            500                 505                 510         
Val Thr Gln Glu Gln Pro Val Cys Met Leu Phe Glu Tyr Ile Asn Gln
        515                 520                 525             
Gly Asp Leu His Glu Phe Leu Ile Met Arg Ser Pro His Ser Asp Val
    530                 535                 540                 
Gly Cys Ser Ser Asp Glu Asp Gly Thr Val Lys Ser Ser Leu Asp His
545                 550                 555                 560 
Gly Asp Phe Leu His Ile Ala Ile Gln Ile Ala Ala Gly Met Glu Tyr
                565                 570                 575     
Leu Ser Ser His Phe Phe Val His Lys Asp Leu Ala Ala Arg Asn Ile
            580                 585                 590         
Leu Ile Gly Glu Gln Leu His Val Lys Ile Ser Asp Leu Gly Leu Ser
        595                 600                 605             
Arg Glu Ile Tyr Ser Ala Asp Tyr Tyr Arg Val Gln Ser Lys Ser Leu
    610                 615                 620                 
Leu Pro Ile Arg Trp Met Pro Pro Glu Ala Ile Met Tyr Gly Lys Phe
625                 630                 635                 640 
Ser Ser Asp Ser Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Ile
                645                 650                 655     
Phe Ser Phe Gly Leu Gln Pro Tyr Tyr Gly Phe Ser Asn Gln Glu Val
            660                 665                 670         
Ile Glu Met Val Arg Lys Arg Gln Leu Leu Pro Cys Ser Glu Asp Cys
        675                 680                 685             
Pro Pro Arg Met Tyr Ser Leu Met Thr Glu Cys Trp Asn Glu Ile Pro
    690                 695                 700                 
Ser Arg Arg Pro Arg Phe Lys Asp Ile His Val Arg Leu Arg Ser Trp
705                 710                 715                 720 
Glu Gly Leu Ser Ser His Thr Ser Ser Thr Thr Pro Ser Gly Gly Asn
                725                 730                 735     
Ala Thr Thr Gln Thr Thr Ser Leu Ser Ala Ser Pro Val Ser Asn Leu
            740                 745                 750         
Ser Asn Pro Arg Tyr Pro Asn Tyr Met Phe Pro Ser Gln Gly Ile Thr
        755                 760                 765             
Pro Gln Gly Gln Ile Ala Gly Phe Ile Gly Pro Pro Ile Pro Gln Asn
    770                 775                 780                 
Gln Arg Phe Ile Pro Ile Asn Gly Tyr Pro Ile Pro Pro Gly Tyr Ala
785                 790                 795                 800 
Ala Phe Pro Ala Ala His Tyr Gln Pro Thr Gly Pro Pro Arg Val Ile
                805                 810                 815     
Gln His Cys Pro Pro Pro Lys Ser Arg Ser Pro Ser Ser Ala Ser Gly
            820                 825                 830         
Ser Thr Ser Thr Gly His Val Thr Ser Leu Pro Ser Ser Gly Ser Asn
        835                 840                 845             
Gln Glu Ala Asn Ile Pro Leu Leu Pro His Met Ser Ile Pro Asn His
    850                 855                 860                 
Pro Gly Gly Met Gly Ile Thr Val Phe Gly Asn Lys Ser Gln Lys Pro
865                 870                 875                 880 
Tyr Lys Ile Asp Ser Lys Gln Ala Ser Leu Leu Gly Asp Ala Asn Ile
                885                 890                 895     
His Gly His Thr Glu Ser Met Ile Ser Ala Glu Leu
            900                 905             


<210> 104
<211> 520
<212> PRT
<213> Homo sapiens

<220> 
<223> ROR1 Isoform short

<400> 104
Gln Glu Thr Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser
 1               5                  10                  15      
Trp Asn Ile Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp
            20                  25                  30          
Glu Pro Met Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu
        35                  40                  45              
His Cys Lys Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys
    50                  55                  60                  
Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser
65                  70                  75                  80  
Thr Ile Tyr Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp
                85                  90                  95      
Thr Gly Tyr Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser
            100                 105                 110         
Ser Thr Gly Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser
        115                 120                 125             
Pro Gly Tyr Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr
    130                 135                 140                 
Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met
145                 150                 155                 160 
Glu Ser Leu His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala
                165                 170                 175     
Phe Thr Met Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln
            180                 185                 190         
Phe Ala Ile Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu
        195                 200                 205             
Thr Ser Ser Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu
    210                 215                 220                 
Ile Leu Glu Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser
225                 230                 235                 240 
Asn Pro Met Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu
                245                 250                 255     
Pro Gln Pro Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile
            260                 265                 270         
Pro Met Ala Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr
        275                 280                 285             
Gly Val Asp Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln
    290                 295                 300                 
Cys Gln Pro Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala
305                 310                 315                 320 
Leu Arg Phe Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro
                325                 330                 335     
Gly Asn Gln Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe
            340                 345                 350         
Lys Ser Asp Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys
        355                 360                 365             
Glu Lys Asn Lys Met Glu Ile Leu Tyr Ile Leu Val Pro Ser Val Ala
    370                 375                 380                 
Ile Pro Leu Ala Ile Ala Leu Leu Phe Phe Phe Ile Cys Val Cys Arg
385                 390                 395                 400 
Asn Asn Gln Lys Ser Ser Ser Ala Pro Val Gln Arg Gln Pro Lys His
                405                 410                 415     
Val Arg Gly Gln Asn Val Glu Met Ser Met Leu Asn Ala Tyr Lys Pro
            420                 425                 430         
Lys Ser Lys Ala Lys Glu Leu Pro Leu Ser Ala Val Arg Phe Met Glu
        435                 440                 445             
Glu Leu Gly Glu Cys Ala Phe Gly Lys Ile Tyr Lys Gly His Leu Tyr
    450                 455                 460                 
Leu Pro Gly Met Asp His Ala Gln Leu Val Ala Ile Lys Thr Leu Lys
465                 470                 475                 480 
Asp Tyr Asn Asn Pro Gln Gln Trp Thr Glu Phe Gln Gln Glu Ala Ser
                485                 490                 495     
Leu Met Ala Glu Leu His His Pro Asn Ile Val Cys Leu Leu Gly Ala
            500                 505                 510         
Val Thr Gln Glu Gln Pro Val Cys
        515                 520 


<210> 105
<211> 364
<212> PRT
<213> Homo sapiens

<220> 
<223> ROR1 isoform 3

<400> 105
Gln Glu Thr Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser
 1               5                  10                  15      
Trp Asn Ile Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp
            20                  25                  30          
Glu Pro Met Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu
        35                  40                  45              
His Cys Lys Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys
    50                  55                  60                  
Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser
65                  70                  75                  80  
Thr Ile Tyr Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp
                85                  90                  95      
Thr Gly Tyr Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser
            100                 105                 110         
Ser Thr Gly Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser
        115                 120                 125             
Pro Gly Tyr Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr
    130                 135                 140                 
Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met
145                 150                 155                 160 
Glu Ser Leu His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala
                165                 170                 175     
Phe Thr Met Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln
            180                 185                 190         
Phe Ala Ile Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu
        195                 200                 205             
Thr Ser Ser Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu
    210                 215                 220                 
Ile Leu Glu Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser
225                 230                 235                 240 
Asn Pro Met Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu
                245                 250                 255     
Pro Gln Pro Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile
            260                 265                 270         
Pro Met Ala Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr
        275                 280                 285             
Gly Val Asp Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln
    290                 295                 300                 
Cys Gln Pro Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala
305                 310                 315                 320 
Leu Arg Phe Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro
                325                 330                 335     
Gly Asn Gln Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe
            340                 345                 350         
Lys Ser Asp Leu Cys Asp Ile Pro Ala Cys Gly Lys
        355                 360                 


<210> 106
<211> 908
<212> PRT
<213> Mus musculus

<220> 
<223> Mouse ROR1, GenBank No. NP_038873

<400> 106
Gln Glu Thr Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser
 1               5                  10                  15      
Trp Asn Thr Ser Ser Glu Ile Asp Lys Gly Ser Tyr Leu Thr Leu Asp
            20                  25                  30          
Glu Pro Met Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu
        35                  40                  45              
His Cys Lys Val Ser Gly Asn Pro Pro Pro Ser Ile Arg Trp Phe Lys
    50                  55                  60                  
Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ser Phe Arg Ala
65                  70                  75                  80  
Thr Asn Tyr Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp
                85                  90                  95      
Thr Gly Tyr Phe Gln Cys Val Ala Thr Asn Gly Lys Lys Val Val Ser
            100                 105                 110         
Thr Thr Gly Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser
        115                 120                 125             
Pro Gly Ser Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr
    130                 135                 140                 
Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met
145                 150                 155                 160 
Glu Ser Leu His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala
                165                 170                 175     
Phe Thr Met Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln
            180                 185                 190         
Phe Ala Ile Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu
        195                 200                 205             
Thr Ser Ser Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu
    210                 215                 220                 
Val Leu Glu Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser
225                 230                 235                 240 
Asn Pro Met Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu
                245                 250                 255     
Pro Gln Pro Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile
            260                 265                 270         
Pro Met Ala Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr
        275                 280                 285             
Gly Val Asp Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln
    290                 295                 300                 
Cys Gln Pro Trp Asn Ser Gln Tyr Pro His Thr His Ser Phe Thr Ala
305                 310                 315                 320 
Leu Arg Phe Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro
                325                 330                 335     
Gly Asn Gln Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe
            340                 345                 350         
Lys Ser Asp Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys
        355                 360                 365             
Glu Lys Asn Lys Met Glu Ile Leu Tyr Ile Leu Val Pro Ser Val Ala
    370                 375                 380                 
Ile Pro Leu Ala Ile Ala Phe Leu Phe Phe Phe Ile Cys Val Cys Arg
385                 390                 395                 400 
Asn Asn Gln Lys Ser Ser Ser Pro Pro Val Gln Arg Gln Pro Lys Pro
                405                 410                 415     
Val Arg Gly Gln Asn Val Glu Met Ser Met Leu Asn Ala Tyr Lys Pro
            420                 425                 430         
Lys Ser Lys Ala Lys Glu Leu Pro Leu Ser Ala Val Arg Phe Met Glu
        435                 440                 445             
Glu Leu Gly Glu Cys Thr Phe Gly Lys Ile Tyr Lys Gly His Leu Tyr
    450                 455                 460                 
Leu Pro Gly Met Asp His Ala Gln Leu Val Ala Ile Lys Thr Leu Lys
465                 470                 475                 480 
Asp Tyr Asn Asn Pro Gln Gln Trp Thr Glu Phe Gln Gln Glu Ala Ser
                485                 490                 495     
Leu Met Ala Glu Leu His His Pro Asn Ile Val Cys Leu Leu Gly Ala
            500                 505                 510         
Val Thr Gln Glu Gln Pro Val Cys Met Leu Phe Glu Tyr Met Asn Gln
        515                 520                 525             
Gly Asp Leu His Glu Phe Leu Ile Met Arg Ser Pro His Ser Asp Val
    530                 535                 540                 
Gly Cys Ser Ser Asp Glu Asp Gly Thr Val Lys Ser Ser Leu Asp His
545                 550                 555                 560 
Gly Asp Phe Leu His Ile Ala Ile Gln Ile Ala Ala Gly Met Glu Tyr
                565                 570                 575     
Leu Ser Ser His Phe Phe Val His Lys Asp Leu Ala Ala Arg Asn Ile
            580                 585                 590         
Leu Ile Gly Glu Gln Leu His Val Lys Ile Ser Asp Leu Gly Leu Ser
        595                 600                 605             
Arg Glu Ile Tyr Ser Ala Asp Tyr Tyr Arg Val Gln Ser Lys Ser Ser
    610                 615                 620                 
Leu Pro Ile Arg Trp Met Pro Pro Glu Ala Ile Met Tyr Gly Lys Phe
625                 630                 635                 640 
Ser Ser Asp Ser Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Ile
                645                 650                 655     
Phe Ser Phe Gly Leu Gln Pro Tyr Tyr Gly Phe Ser Asn Gln Glu Val
            660                 665                 670         
Ile Glu Met Val Arg Lys Arg Gln Leu Leu Pro Cys Ser Glu Asp Cys
        675                 680                 685             
Pro Pro Arg Met Tyr Ser Leu Met Thr Glu Cys Trp Asn Glu Ile Pro
    690                 695                 700                 
Ser Arg Arg Pro Arg Phe Lys Asp Ile His Val Arg Leu Arg Ser Trp
705                 710                 715                 720 
Glu Gly Leu Ser Ser His Thr Ser Ser Thr Thr Pro Ser Gly Gly Asn
                725                 730                 735     
Ala Thr Thr Gln Thr Thr Ser Leu Ser Ala Ser Pro Val Ser Asn Leu
            740                 745                 750         
Ser Asn Pro Arg Phe Pro Asn Tyr Met Phe Pro Ser Gln Gly Ile Thr
        755                 760                 765             
Pro Gln Gly Gln Ile Ala Gly Phe Ile Gly Pro Ala Ile Pro Gln Asn
    770                 775                 780                 
Gln Arg Phe Ile Pro Ile Asn Gly Tyr Pro Ile Pro Pro Gly Tyr Ala
785                 790                 795                 800 
Ala Phe Pro Ala Ala His Tyr Gln Pro Ala Gly Pro Pro Arg Val Ile
                805                 810                 815     
Gln His Cys Pro Pro Pro Lys Ser Arg Ser Pro Ser Ser Ala Ser Gly
            820                 825                 830         
Ser Thr Ser Thr Gly His Val Ala Ser Leu Pro Ser Ser Gly Ser Asn
        835                 840                 845             
Gln Glu Ala Asn Val Pro Leu Leu Pro His Met Ser Ile Pro Asn His
    850                 855                 860                 
Pro Gly Gly Met Gly Ile Thr Val Phe Gly Asn Lys Ser Gln Lys Pro
865                 870                 875                 880 
Tyr Lys Ile Asp Ser Lys Gln Ser Ser Leu Leu Gly Asp Ser His Ile
                885                 890                 895     
His Gly His Thr Glu Ser Met Ile Ser Ala Glu Val
            900                 905             


<210> 107
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> spacer (IgG4hinge)

<400> 107
gaatctaagt acggaccgcc ctgcccccct tgccct                           36

<210> 108
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> spacer (IgG4hinge)

<400> 108
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro
 1               5                  10          


<210> 109
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Consensus  CDR-H3

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = V or D

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = S or N

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = D or E

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = Y or A

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = F or Y

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = F or null

<220> 
<221> VARIANT        
<222> 10
<223> Xaa = I or Y

<400> 109
Xaa Ser Xaa Tyr Xaa Xaa Xaa Xaa Asp Xaa
 1               5                  10  


<210> 110
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Consensus CDR-H3

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = S, N, or R

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = N or G

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Y, G, or S

<400> 110
Val Xaa Xaa Xaa Glu Tyr Tyr Phe Asp Tyr
 1               5                  10  


<210> 111
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> 4GS linker

<400> 111
Gly Gly Gly Gly Ser
 1               5  


<210> 112
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> 3GS linker

<400> 112
Gly Gly Gly Ser
 1              


<210> 113
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> Linker

<400> 113
Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr
 1               5                  10                  15      
Lys Gly
        

<210> 114
<211> 118
<212> PRT
<213> Mus musculus

<220> 
<223> 2A2 VH

<400> 114
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr
            20                  25                  30          
Glu Met His Trp Val Ile Gln Thr Pro Val His Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Gly Tyr Tyr Asp Tyr Asp Ser Phe Thr Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ala
        115             


<210> 115
<211> 107
<212> PRT
<213> Mus musculus

<220> 
<223> 2A2 VL

<400> 115
Asp Ile Val Met Thr Gln Ser Gln Lys Ile Met Ser Thr Thr Val Gly
 1               5                  10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Ala Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser
65                  70                  75                  80  
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asp Ile Tyr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 116
<211> 5
<212> PRT
<213> Mus musculus

<220> 
<223> 2A2 CDR-H1

<400> 116
Asp Tyr Glu Met His
 1               5  


<210> 117
<211> 17
<212> PRT
<213> Mus musculus

<220> 
<223> 2A2 CDR-H2

<400> 117
Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe Lys
 1               5                  10                  15      
Gly
    

<210> 118
<211> 9
<212> PRT
<213> Mus musculus

<220> 
<223> 2A2 CDR-H3

<400> 118
Tyr Tyr Asp Tyr Asp Ser Phe Thr Tyr
 1               5                  


<210> 119
<211> 11
<212> PRT
<213> Mus musculus

<220> 
<223> 2A2 CDR-L1

<400> 119
Lys Ala Ser Gln Asn Val Asp Ala Ala Val Ala
 1               5                  10      


<210> 120
<211> 7
<212> PRT
<213> Mus musculus

<220> 
<223> 2A2 CDR-L2

<400> 120
Ser Ala Ser Asn Arg Tyr Thr
 1               5          


<210> 121
<211> 9
<212> PRT
<213> Mus musculus

<220> 
<223> 2A2 CDR-L3

<400> 121
Gln Gln Tyr Asp Ile Tyr Pro Tyr Thr
 1               5                  


<210> 122
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> 99961 humanized VH

<400> 122
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ala Phe Thr Ala Tyr
            20                  25                  30          
Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ser Phe Asp Pro Tyr Asp Gly Gly Ser Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val
65                  70                  75                  80  
Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Trp Tyr Tyr Phe Asp Tyr Trp Gly His Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 123
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> 99961 humanized VH

<400> 123
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ala Phe Thr Ala Tyr
            20                  25                  30          
Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ser Phe Asp Pro Tyr Asp Gly Gly Ser Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val
65                  70                  75                  80  
Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Trp Tyr Tyr Phe Asp Tyr Trp Gly His Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 124
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> 99961 humanized VH

<400> 124
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ala Phe Thr Ala Tyr
            20                  25                  30          
Asn Ile His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ser Phe Asp Pro Tyr Asp Gly Gly Ser Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val
65                  70                  75                  80  
Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Trp Tyr Tyr Phe Asp Tyr Trp Gly His Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 125
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> 99961 humanized VH

<400> 125
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ala Phe Thr Ala Tyr
            20                  25                  30          
Asn Ile His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ser Phe Asp Pro Tyr Asp Gly Gly Ser Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val
65                  70                  75                  80  
Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Trp Tyr Tyr Phe Asp Tyr Trp Gly His Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 126
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> 99961 humanized VL

<400> 126
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly
 1               5                  10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Pro Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Ile Glu Ser
65                  70                  75                  80  
Glu Asp Ala Ala Tyr Tyr Phe Cys Gln Gln His Asp Glu Ser Pro Tyr
                85                  90                  95      
Thr Phe Gly Glu Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 127
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 127
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Pro Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Ile Glu Ser
65                  70                  75                  80  
Glu Asp Ala Ala Tyr Tyr Phe Cys Gln Gln His Asp Glu Ser Pro Tyr
                85                  90                  95      
Thr Phe Gly Glu Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 128
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> 99961 humanized VL

<400> 128
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly
 1               5                  10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Pro Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Ile Glu Ser
65                  70                  75                  80  
Glu Asp Ala Ala Tyr Tyr Phe Cys Gln Gln His Asp Glu Ser Pro Tyr
                85                  90                  95      
Thr Phe Gly Glu Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 129
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> 99961 humanized VL

<400> 129
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Pro Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Ile Glu Ser
65                  70                  75                  80  
Glu Asp Ala Ala Tyr Tyr Phe Cys Gln Gln His Asp Glu Ser Pro Tyr
                85                  90                  95      
Thr Phe Gly Glu Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 130
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> 99961 humanized CDR-H1

<400> 130
Ser Gly Tyr Ala Phe Thr Ala Tyr Asn Ile His Trp Val Arg Gln
 1               5                  10                  15  


<210> 131
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> 99961 humanized CDR-H2

<400> 131
Gly Ser Phe Asp Pro Tyr Asp Gly Gly Ser Ser Tyr Asn Gln Lys Phe
 1               5                  10                  15      
Lys Asp
        

<210> 132
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> 99961 humanized CDR-H3

<400> 132
Tyr Tyr Cys Ala Arg Gly Trp Tyr Tyr Phe Asp Tyr Trp Gly His Gly
 1               5                  10                  15      
Thr Leu Val Thr Val Ser Ser
            20              


<210> 133
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> 99961 humanized CDR-H1

<400> 133
Gly Tyr Ala Phe Thr Ala Tyr Asn
 1               5              


<210> 134
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> 99961 humanized CDR-H2

<400> 134
Phe Asp Pro Tyr Asp Gly Gly Ser
 1               5              


<210> 135
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> 99961 humanized CDR-H3

<400> 135
Gly Trp Tyr Tyr Phe Asp Tyr
 1               5          


<210> 136
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> 99961 humanized CDR-L1

<400> 136
Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala Trp Tyr
 1               5                  10                  


<210> 137
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> 99961 humanized CDR-L2

<400> 137
Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly
 1               5                  10          


<210> 138
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> 99961 humanized CDR-L3

<400> 138
Cys Gln Gln His Asp Glu Ser Pro Tyr Thr Phe Gly Glu Gly Thr Lys
 1               5                  10                  15      


<210> 139
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> 99961 humanized CDR-L1

<400> 139
Lys Ser Ile Ser Lys Tyr
 1               5      


<210> 140
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> 99961 humanized CDR-L2

<400> 140
Ser Gly Ser
 1          


<210> 141
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> 99961 humanized CDR-L3

<400> 141
Gln Gln His Asp Glu Ser Pro Tyr
 1               5              


<210> 142
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> Hinge-CH3 spacer

<400> 142
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg
 1               5                  10                  15      
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys
            20                  25                  30          
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
        35                  40                  45              
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
    50                  55                  60                  
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
65                  70                  75                  80  
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser
                85                  90                  95      
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
            100                 105                 110         
Leu Ser Leu Ser Leu Gly Lys
        115                 


<210> 143
<211> 229
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> Hinge-CH2-CH3 spacer

<400> 143
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe
 1               5                  10                  15      
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
            20                  25                  30          
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
        35                  40                  45              
Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val
    50                  55                  60                  
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser
65                  70                  75                  80  
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
                85                  90                  95      
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser
            100                 105                 110         
Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
        115                 120                 125             
Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln
    130                 135                 140                 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
145                 150                 155                 160 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
                165                 170                 175     
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu
            180                 185                 190         
Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser
        195                 200                 205             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
    210                 215                 220                 
Leu Ser Leu Gly Lys
225                 


<210> 144
<211> 282
<212> PRT
<213> Homo sapiens

<220> 
<223> IgD-hinge-Fc

<400> 144
Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala
 1               5                  10                  15      
Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala
            20                  25                  30          
Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys
        35                  40                  45              
Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro
    50                  55                  60                  
Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln
65                  70                  75                  80  
Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly
                85                  90                  95      
Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val
            100                 105                 110         
Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly
        115                 120                 125             
Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn
    130                 135                 140                 
Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro Pro
145                 150                 155                 160 
Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys
                165                 170                 175     
Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Ser
            180                 185                 190         
Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu Leu
        195                 200                 205             
Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala Pro
    210                 215                 220                 
Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp Ser
225                 230                 235                 240 
Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr Thr
                245                 250                 255     
Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser Arg
            260                 265                 270         
Ser Leu Glu Val Ser Tyr Val Thr Asp His
        275                 280         


<210> 145
<211> 27
<212> PRT
<213> Homo sapiens

<220> 
<223> CD28, Accession No. P10747

<400> 145
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu
 1               5                  10                  15      
Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
            20                  25          


<210> 146
<211> 66
<212> PRT
<213> Homo sapiens

<220> 
<223> CD28, Accession No. P10747

<400> 146
Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
 1               5                  10                  15      
Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
            20                  25                  30          
Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
        35                  40                  45              
Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
    50                  55                  60                  
Trp Val
65      


<210> 147
<211> 41
<212> PRT
<213> Homo sapiens

<220> 
<223> CD28, Accession No. P10747

<400> 147
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr
 1               5                  10                  15      
Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
            20                  25                  30          
Pro Arg Asp Phe Ala Ala Tyr Arg Ser
        35                  40      


<210> 148
<211> 41
<212> PRT
<213> Homo sapiens

<220> 
<223> CD28, LL to GG

<400> 148
Arg Ser Lys Arg Ser Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr
 1               5                  10                  15      
Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
            20                  25                  30          
Pro Arg Asp Phe Ala Ala Tyr Arg Ser
        35                  40      


<210> 149
<211> 42
<212> PRT
<213> Homo sapiens

<220> 
<223> 4-1BB, Accession No. Q07011.1

<400> 149
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met
 1               5                  10                  15      
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe
            20                  25                  30          
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu
        35                  40          


<210> 150
<211> 112
<212> PRT
<213> Homo sapiens

<220> 
<223> CD3 zeta

<400> 150
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly
 1               5                  10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys
        35                  40                  45              
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys
    50                  55                  60                  
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg
65                  70                  75                  80  
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala
                85                  90                  95      
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
            100                 105                 110         


<210> 151
<211> 112
<212> PRT
<213> Homo sapiens

<220> 
<223> CD3 zeta

<400> 151
Arg Val Lys Phe Ser Arg Ser Ala Glu Pro Pro Ala Tyr Gln Gln Gly
 1               5                  10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys
        35                  40                  45              
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys
    50                  55                  60                  
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg
65                  70                  75                  80  
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala
                85                  90                  95      
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
            100                 105                 110         


<210> 152
<211> 112
<212> PRT
<213> Homo sapiens

<220> 
<223> CD3 zeta

<400> 152
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly
 1               5                  10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys
        35                  40                  45              
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys
    50                  55                  60                  
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg
65                  70                  75                  80  
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala
                85                  90                  95      
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
            100                 105                 110         


<210> 153
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> T2A

<400> 153
Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp
 1               5                  10                  15      
Val Glu Glu Asn Pro Gly Pro Arg
            20                  


<210> 154
<211> 357
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<223> tEGFR

<400> 154
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly
            20                  25                  30          
Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe
        35                  40                  45              
Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala
    50                  55                  60                  
Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu
65                  70                  75                  80  
Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile
                85                  90                  95      
Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu
            100                 105                 110         
Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala
        115                 120                 125             
Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu
    130                 135                 140                 
Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr
145                 150                 155                 160 
Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys
                165                 170                 175     
Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly
            180                 185                 190         
Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu
        195                 200                 205             
Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys
    210                 215                 220                 
Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu
225                 230                 235                 240 
Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met
                245                 250                 255     
Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala
            260                 265                 270         
His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val
        275                 280                 285             
Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His
    290                 295                 300                 
Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro
305                 310                 315                 320 
Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala
                325                 330                 335     
Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly
            340                 345                 350         
Ile Gly Leu Phe Met
        355         

<210> 155
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 65 CDR-H1

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = any amino acid

<400> 155
Xaa Arg Leu Asp Glu
 1               5  


<210> 156
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V128 CDR-H1

<400> 156
Thr Phe Trp Met Ser
 1               5  


<210> 157
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V71 CDR-H1

<400> 157
Thr Ser Ala Met Ser
 1               5  


<210> 158
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V86, V278, V365 CDR-H1

<400> 158
Ser Tyr Ala Met Ser
 1               5  


<210> 159
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V316 CDR-H1

<400> 159
Arg Thr Trp Met Ser
 1               5  


<210> 160
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V331, V345 CDR-H1

<400> 160
Gly Tyr Tyr Trp Ser
 1               5  


<210> 161
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V355 CDR-H1

<400> 161
Ser Tyr Ala Ile Ser
 1               5  


<210> 162
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V420, V282 CDR-H1

<400> 162
Ser Tyr Trp Met Ser
 1               5  


<210> 163
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V336 CDR-H1

<400> 163
Ser Tyr Ala Met His
 1               5  


<210> 164
<211> 19
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 461, V68, V102, V181 CDR-H2

<400> 164
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
 1               5                  10                  15      
Val Lys Gly
            

<210> 165
<211> 17
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V71 CDR-H2

<400> 165
Thr Ile Ser Thr Asp Gly Ala Thr Thr Trp Tyr Ala Asp Ser Val Arg
 1               5                  10                  15      
Gly
    

<210> 166
<211> 17
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V86, V278, V365 CDR-H2

<400> 166
Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    

<210> 167
<211> 17
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V316 CDR-H2

<400> 167
Ser Ile Asn Asp Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys
 1               5                  10                  15      
Gly
    

<210> 168
<211> 16
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V331 CDR-H2

<400> 168
Lys Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser
 1               5                  10                  15      


<210> 169
<211> 17
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V355 CDR-H2

<400> 169
Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln
 1               5                  10                  15      
Gly
    

<210> 170
<211> 17
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V282, V420 CDR-H2

<400> 170
Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys
 1               5                  10                  15      
Gly
    

<210> 171
<211> 19
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V397 CDR-H2

<400> 171
Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala Pro
 1               5                  10                  15      
Leu Lys Gly
            

<210> 172
<211> 16
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V345 CDR-H2

<400> 172
Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser
 1               5                  10                  15      


<210> 173
<211> 16
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V336 CDR-H2

<220> 
<221> VARIANT        
<222> 15
<223> Xaa = any amino acid

<400> 173
Val Ile Ser Tyr Asp Gly Ser Thr Asn Tyr Asn Pro Ser Leu Xaa Ser
 1               5                  10                  15      


<210> 174
<211> 14
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V336 CDR-H3

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = any amino acid

<400> 174
Val Tyr Gly Tyr Asp Tyr Xaa Asp Phe Gly Trp Phe Asp Pro
 1               5                  10                  


<210> 175
<211> 122
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 7 VH

<400> 175
Gln Ile Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Arg Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Leu Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Glu Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Ser Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 176
<211> 122
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 81 VH

<400> 176
Gln Ile Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Ser Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 177
<211> 122
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 16 VH

<220> 
<221> VARIANT        
<222> 4, 11
<223> Xaa = any amino acid

<400> 177
Arg Ser Pro Xaa Arg Ser Leu Gly Glu Ala Xaa Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Gly Ser Ala Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Ser Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 178
<211> 122
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 65 VH

<220> 
<221> VARIANT        
<222> 31
<223> Xaa = any amino acid

<400> 178
Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gln Xaa Arg
            20                  25                  30          
Leu Asp Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Ser Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 179
<211> 122
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V18 VH

<400> 179
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 180
<211> 122
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 40 VH

<400> 180
Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Ser Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 181
<211> 122
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 40 VH

<400> 181
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Ser Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 182
<211> 119
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 350, 305, 366 VH

<400> 182
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Arg Ser Thr Asp His Ala Asp Tyr Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr
65                  70                  75                  80  
Leu Gln Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Val Ser Asn Tyr Glu Tyr Tyr Phe Asp Tyr Trp Ala Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 183
<211> 122
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 20, 43 VH

<400> 183
Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Ser Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 184
<211> 122
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 20, 43 VH

<400> 184
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Ser Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 185
<211> 125
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 461 VH

<400> 185
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30          
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Lys Asp Phe Glu Val Arg Glu Ala His Leu Ser Tyr Phe
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125 


<210> 186
<211> 125
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 461 VH

<400> 186
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30          
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Lys Asp Phe Glu Val Arg Glu Ala His Leu Ser Tyr Phe
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125 


<210> 187
<211> 125
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V9 VH

<400> 187
Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Lys Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Gly Ser Asn Glu Arg Phe Leu Glu Trp Leu Asn Phe
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125 


<210> 188
<211> 122
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V128 VH

<400> 188
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Phe
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Ser Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 189
<211> 125
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V68 VH

<400> 189
Gln Ile Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30          
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Lys Asp Phe Glu Val Arg Gly Ala His Leu Ser Tyr Phe
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125 


<210> 190
<211> 123
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V71 VH

<400> 190
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Ser
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Thr Ile Ser Thr Asp Gly Ala Thr Thr Trp Tyr Ala Asp Ser Val
    50                  55                  60                  
Arg Gly Arg Phe Ser Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Thr Gly Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Val Leu Arg Ser Gly Phe Leu Glu Trp Asn Leu Phe Asp Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120             


<210> 191
<211> 120
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V86 VH

<400> 191
Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Val Ile Phe Gly Val Val Asn Ile Pro Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 192
<211> 125
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V224 VH

<400> 192
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ile Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Thr Tyr Ser Ser Ser Trp Tyr Glu Ser Leu Leu Phe
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125 


<210> 193
<211> 127
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V163 VH

<400> 193
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Gln Gly Asp Ser Ser Ser Trp Tyr Val Glu Val Tyr
            100                 105                 110         
Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125         


<210> 194
<211> 126
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V95 VH

<400> 194
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Lys Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Gly Ser Gly Glu Leu Arg Phe Leu Glu Ser Tyr Tyr
            100                 105                 110         
Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125     


<210> 195
<211> 122
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V102 VH

<400> 195
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Ile
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asp Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Lys Val Gly Pro Ser Trp Asp Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 196
<211> 125
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V181 VH

<400> 196
Gln Ile Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30          
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Lys Asp Phe Glu Val Arg Glu Ala His Leu Ser Tyr Phe
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125 


<210> 197
<211> 125
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V312 VH

<400> 197
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Arg Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Thr Ser Arg Gly Arg Phe Leu Glu Trp Leu Leu Phe
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125 


<210> 198
<211> 123
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V316 VH

<400> 198
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Arg Thr
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Asn Asp Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Val Asp Ser Glu Arg Phe Leu Glu Trp Tyr Tyr Phe Asp Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120             


<210> 199
<211> 121
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V331 VH

<400> 199
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Lys Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Gly Gln Ile Ala Ala His Val Trp Gly Trp Phe Asp Pro Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120     


<210> 200
<211> 121
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V278 VH

<400> 200
Gln Ile Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Glu Arg Ser Arg Trp Gly Asp Asn Trp Phe Asp Pro Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120     


<210> 201
<211> 118
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V355 VH

<400> 201
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ile Tyr Pro Pro Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr
            100                 105                 110         
Met Val Thr Val Ser Ser
        115             


<210> 202
<211> 125
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V357 VH

<400> 202
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Met Val Gly Ala Trp Leu Val Leu Ser Tyr Phe
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125 


<210> 203
<211> 119
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V282 VH

<400> 203
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Val Arg Gly Ser Glu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 204
<211> 125
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V365 VH

<400> 204
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Gly Ile Gly Tyr Ser Ser Ser Trp Tyr Glu Ile Trp Thr Phe
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125 


<210> 205
<211> 125
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V397 VH

<400> 205
Gln Ile Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Leu Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Ala Lys Gly Leu Trp Phe Gly Glu Ser Tyr Tyr Phe
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125 


<210> 206
<211> 119
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V420 VH

<400> 206
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Val Asn Gly Gly Glu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 207
<211> 121
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V345 VH

<400> 207
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Gly Pro Leu Arg Pro Gln Lys Val Leu Pro Phe Gln Ile Gly Ala
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120     


<210> 208
<211> 122
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V336 VH

<220> 
<221> VARIANT        
<222> 64
<223> Xaa = any amino acid

<400> 208
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Thr Asn Tyr Asn Pro Ser Leu Xaa
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Val Tyr Gly Tyr Asp Tyr Arg Asp Phe Gly Trp Phe Asp Pro Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 209
<211> 122
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V336 VH

<220> 
<221> VARIANT        
<222> 64, 104
<223> Xaa = any amino acid

<400> 209
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Thr Asn Tyr Asn Pro Ser Leu Xaa
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Val Tyr Gly Tyr Asp Tyr Xaa Asp Phe Gly Trp Phe Asp Pro Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 210
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 7 CDR-L1

<400> 210
Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala Cys
 1               5                  10      


<210> 211
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 81 CDR-L1

<400> 211
Gly Gly Asn Asn Ile Gly Thr Lys Ser Val His
 1               5                  10      


<210> 212
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 16 CDR-L1

<400> 212
Arg Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ala
 1               5                  10      


<210> 213
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 65 CDR-L1

<400> 213
Pro Arg Arg Gln Pro Gln Lys Thr Ile Met Gln
 1               5                  10      


<210> 214
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V18 CDR-L1

<400> 214
Gly Gly Asn Asn Leu Gly Ser Lys Asn Val His
 1               5                  10      


<210> 215
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 40 CDR-L1

<400> 215
Thr Arg Ser Ser Gly Asn Ile Ala Ser Asn Phe Val Gln
 1               5                  10              


<210> 216
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 350 CDR-L1

<400> 216
Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln
 1               5                  10              


<210> 217
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 20 CDR-L1

<400> 217
Arg Ala Ser Gln Ser Ile Asn Lys Trp Leu Ala
 1               5                  10      


<210> 218
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 305 CDR-L1

<400> 218
Gly Gly Asn Asn Ile Gly Ser Thr Ser Val His
 1               5                  10      


<210> 219
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 366 CDR-L1

<400> 219
Ser Gly Ser Arg Phe Asn Ile Gly Ser Asn Thr Val Asn
 1               5                  10              


<210> 220
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 461 CDR-L1

<400> 220
Gly Gly Asn Arg Ile Gly Thr Lys Ala Val His
 1               5                  10      


<210> 221
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 7 CDR-L2

<400> 221
Gln Asp Ser Lys Arg Pro Ser
 1               5          


<210> 222
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 81 CDR-L2

<400> 222
Asp Glu Ser Asp Arg Pro Ser
 1               5          


<210> 223
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 16 CDR-L2

<400> 223
Ala Ala Ser Thr Leu Gln Ser
 1               5          


<210> 224
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 65 CDR-L2

<400> 224
Gly Lys Asn Asp Arg Pro Ser
 1               5          


<210> 225
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V18 CDR-L2

<400> 225
Asp Asp Asp Asn Arg Pro Ser
 1               5          


<210> 226
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 40 CDR-L2

<400> 226
Glu Asp Thr Gln Arg Pro Ser
 1               5          


<210> 227
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 350 CDR-L2

<400> 227
Glu Asp Asn Gln Arg Pro Ser
 1               5          


<210> 228
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 20 CDR-L2

<400> 228
Asp Ala Ser Thr Leu Glu Ser
 1               5          


<210> 229
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 305 CDR-L2

<400> 229
Asp Asp Ser Asp Arg Pro Ser
 1               5          


<210> 230
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 366 CDR-L2

<400> 230
Ser Asn Asn Gln Arg Pro Ser
 1               5          


<210> 231
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 461 CDR-L2

<400> 231
Asp Asp Thr Asp Arg Pro Ser
 1               5          


<210> 232
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V18 CDR-L3

<400> 232
Gln Val Trp Asp Ser Ser Ser Arg His Val Val
 1               5                  10      


<210> 233
<211> 9
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 7 CDR-L3

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = any amino acid

<400> 233
Xaa Ala Trp Asp Ser Ser Thr Val Val
 1               5                  


<210> 234
<211> 106
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 7 VL

<220> 
<221> VARIANT        
<222> (86)...(88)
<223> Xaa = any amino acid

<400> 234
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15      
Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala
            20                  25                  30          
Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
        35                  40                  45              
Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60                  
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Xaa Xaa Xaa Ala Trp Asp Ser Ser Thr Val Val
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105     


<210> 235
<211> 106
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 7 VL

<220> 
<221> VARIANT        
<222> (86)...(87)
<223> Xaa = any amino acid

<400> 235
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15      
Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala
            20                  25                  30          
Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
        35                  40                  45              
Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60                  
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Xaa Xaa Gln Ala Trp Asp Ser Ser Thr Val Val
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105     


<210> 236
<211> 108
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 81 VL

<220> 
<221> VARIANT        
<222> 65, 85, 92, 93, 94, 95
<223> Xaa = any amino acid

<400> 236
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln
 1               5                  10                  15      
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Thr Lys Ser Val
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Leu Tyr
        35                  40                  45              
Asp Glu Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60                  
Xaa Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65                  70                  75                  80  
Asp Glu Ala Asp Xaa Leu Leu Ser Gly Val Gly Xaa Xaa Xaa Xaa Ser
                85                  90                  95      
Leu Cys Phe Gly Ser Gly Thr Lys Leu Thr Val Leu
            100                 105             


<210> 237
<211> 108
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 81 VL

<220> 
<221> VARIANT        
<222> 65, 85
<223> Xaa = any amino acid

<400> 237
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln
 1               5                  10                  15      
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Thr Lys Ser Val
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Leu Tyr
        35                  40                  45              
Asp Glu Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60                  
Xaa Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65                  70                  75                  80  
Asp Glu Ala Asp Xaa Leu Leu Gln Val Trp Asp Ser Ser Ser Asp His
                85                  90                  95      
Tyr Val Phe Gly Ser Gly Thr Lys Leu Thr Val Leu
            100                 105             


<210> 238
<211> 88
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 16 VL

<400> 238
Glu Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Ser His Gln Gly Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys
                85              


<210> 239
<211> 87
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 65 VL

<220> 
<221> VARIANT        
<222> 87
<223> Xaa = any amino acid

<400> 239
Gln Ser Ala Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Thr
 1               5                  10                  15      
Asp Ser Gln Asp His Met Pro Arg Arg Gln Pro Gln Lys Thr Ile Met
            20                  25                  30          
Gln Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ala Leu Val Ile Tyr
        35                  40                  45              
Gly Lys Asn Asp Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
    50                  55                  60                  
Thr Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Xaa
                85          


<210> 240
<211> 106
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V18 VL

<400> 240
Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys Thr Ala
 1               5                  10                  15      
Arg Ile Thr Cys Gly Gly Asn Asn Leu Gly Ser Lys Asn Val His Trp
            20                  25                  30          
Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Asp
        35                  40                  45              
Asp Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser
    50                  55                  60                  
Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu
65                  70                  75                  80  
Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Arg His Val Val
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105     


<210> 241
<211> 110
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 40 VL

<400> 241
Gln Pro Val Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
 1               5                  10                  15      
Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Asn Ile Ala Ser Asn
            20                  25                  30          
Phe Val Gln Trp Tyr Gln Arg Arg Pro Asp Gly Ala Thr Thr Asn Val
        35                  40                  45              
Ile Tyr Glu Asp Thr Gln Arg Pro Ser Gly Val Ser Gly Arg Phe Ser
    50                  55                  60                  
Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65                  70                  75                  80  
Leu Arg Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly
                85                  90                  95      
Arg Asn Leu Met Phe Gly Gly Gly Thr Lys Val Thr Val Leu
            100                 105                 110 


<210> 242
<211> 110
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 350 VL

<400> 242
Gln Pro Val Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
 1               5                  10                  15      
Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn
            20                  25                  30          
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val
        35                  40                  45              
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65                  70                  75                  80  
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser
                85                  90                  95      
Ser Asn His Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu
            100                 105                 110 


<210> 243
<211> 107
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 20 VL

<400> 243
Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Lys Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
His Asp Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu His Pro
65                  70                  75                  80  
Asp Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Leu Lys Ser Pro Pro Ala
                85                  90                  95      
Gln Phe Gly Glu Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 244
<211> 107
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 20 VL

<400> 244
Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Lys Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
His Asp Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu His Pro
65                  70                  75                  80  
Asp Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Leu Lys Ser Arg Pro Leu
                85                  90                  95      
Ser Phe Gly Glu Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 245
<211> 110
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 43 VL

<400> 245
Gln Ser Val Leu Thr Gln Pro Ser Ser Val Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
            20                  25                  30          
Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Gly His Gln Trp Ala Pro
65                  70                  75                  80  
Gly Pro Arg Met Arg Leu Ile Ile Thr Ala Ala Trp Asp Asp Ser Leu
                85                  90                  95      
Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110 


<210> 246
<211> 108
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 305 VL

<400> 246
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln
 1               5                  10                  15      
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Thr Ser Val
            20                  25                  30          
His Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr
        35                  40                  45              
Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60                  
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Asn Asp Ser Asp His
                85                  90                  95      
Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105             


<210> 247
<211> 110
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 366 VL

<400> 247
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Pro Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Thr Cys Ser Gly Ser Arg Phe Asn Ile Gly Ser Asn
            20                  25                  30          
Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
                85                  90                  95      
Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu
            100                 105                 110 


<210> 248
<211> 107
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 461 VL

<220> 
<221> VARIANT        
<222> 69
<223> Xaa = any amino acid

<400> 248
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln
 1               5                  10                  15      
Thr Ala Arg Ile Thr Cys Gly Gly Asn Arg Ile Gly Thr Lys Ala Val
            20                  25                  30          
His Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Val Arg
        35                  40                  45              
Asp Asp Thr Asp Arg Pro Ser Gly Ser Leu Arg Asp Ser Leu Ala Pro
    50                  55                  60                  
Thr Leu Gly Thr Xaa Ala Thr Leu Thr Ile Ser Gly Val Glu Ala Gly
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Gln Val Trp Asp Ser Ser Ser Asp His Arg
                85                  90                  95      
Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105         


<210> 249
<211> 228
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 7 scFv

<220> 
<221> VARIANT        
<222> (208)...(210)
<223> Xaa = any amino acid

<400> 249
Gln Ile Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Arg Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Leu Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Glu Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ser Tyr Glu Leu Thr Gln
        115                 120                 125             
Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr Ala Ser Ile Thr Cys
    130                 135                 140                 
Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala Cys Trp Tyr Gln Gln Lys
145                 150                 155                 160 
Pro Gly Gln Ser Pro Val Leu Val Ile Tyr Gln Asp Ser Lys Arg Pro
                165                 170                 175     
Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala
            180                 185                 190         
Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Xaa
        195                 200                 205             
Xaa Xaa Ala Trp Asp Ser Ser Thr Val Val Phe Gly Gly Gly Thr Lys
    210                 215                 220                 
Leu Thr Val Leu
225             


<210> 250
<211> 228
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 7 scFv

<220> 
<221> VARIANT        
<222> (208)...(209)
<223> Xaa = any amino acid

<400> 250
Gln Ile Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Arg Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Leu Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Glu Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ser Tyr Glu Leu Thr Gln
        115                 120                 125             
Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr Ala Ser Ile Thr Cys
    130                 135                 140                 
Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala Cys Trp Tyr Gln Gln Lys
145                 150                 155                 160 
Pro Gly Gln Ser Pro Val Leu Val Ile Tyr Gln Asp Ser Lys Arg Pro
                165                 170                 175     
Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala
            180                 185                 190         
Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Xaa
        195                 200                 205             
Xaa Gln Ala Trp Asp Ser Ser Thr Val Val Phe Gly Gly Gly Thr Lys
    210                 215                 220                 
Leu Thr Val Leu
225             


<210> 251
<211> 230
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 81 scFv

<220> 
<221> VARIANT        
<222> 187, 207, 214, 215, 216, 217
<223> Xaa = any amino acid

<400> 251
Gln Ile Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gln Ser Val Leu Thr Gln
        115                 120                 125             
Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys
    130                 135                 140                 
Gly Gly Asn Asn Ile Gly Thr Lys Ser Val His Trp Tyr Gln Gln Lys
145                 150                 155                 160 
Pro Gly Gln Ala Pro Val Leu Val Leu Tyr Asp Glu Ser Asp Arg Pro
                165                 170                 175     
Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Xaa Ser Gly Asn Thr Ala
            180                 185                 190         
Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Xaa Leu
        195                 200                 205             
Leu Ser Gly Val Gly Xaa Xaa Xaa Xaa Ser Leu Cys Phe Gly Ser Gly
    210                 215                 220                 
Thr Lys Leu Thr Val Leu
225                 230 


<210> 252
<211> 230
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 81 scFv

<220> 
<221> VARIANT        
<222> 187, 207
<223> Xaa = any amino acid

<400> 252
Gln Ile Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gln Ser Val Leu Thr Gln
        115                 120                 125             
Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys
    130                 135                 140                 
Gly Gly Asn Asn Ile Gly Thr Lys Ser Val His Trp Tyr Gln Gln Lys
145                 150                 155                 160 
Pro Gly Gln Ala Pro Val Leu Val Leu Tyr Asp Glu Ser Asp Arg Pro
                165                 170                 175     
Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Xaa Ser Gly Asn Thr Ala
            180                 185                 190         
Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Xaa Leu
        195                 200                 205             
Leu Gln Val Trp Asp Ser Ser Ser Asp His Tyr Val Phe Gly Ser Gly
    210                 215                 220                 
Thr Lys Leu Thr Val Leu
225                 230 


<210> 253
<211> 210
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 16 scFv

<220> 
<221> VARIANT        
<222> 4, 11
<223> Xaa = any amino acid

<400> 253
Arg Ser Pro Xaa Arg Ser Leu Gly Glu Ala Xaa Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Gly Ser Ala Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Ser Gln Gly Thr Leu Val Thr Val Ser Ser Glu Ile Val Met Thr Gln
        115                 120                 125             
Ser Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr
    130                 135                 140                 
Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ala Trp Tyr Gln Gln
145                 150                 155                 160 
Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu
                165                 170                 175     
Gln Ser Gly Ser His Gln Gly Phe Ser Gly Ser Gly Ser Gly Thr Glu
            180                 185                 190         
Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
        195                 200                 205             
Tyr Cys
    210 


<210> 254
<211> 209
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 65 scFv

<220> 
<221> VARIANT        
<222> 31, 209
<223> Xaa = any amino acid

<400> 254
Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gln Xaa Arg
            20                  25                  30          
Leu Asp Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gln Ser Ala Leu Thr Gln
        115                 120                 125             
Asp Pro Ala Val Ser Val Ala Leu Gly Thr Asp Ser Gln Asp His Met
    130                 135                 140                 
Pro Arg Arg Gln Pro Gln Lys Thr Ile Met Gln Trp Tyr Gln Gln Lys
145                 150                 155                 160 
Pro Gly Gln Ala Pro Ala Leu Val Ile Tyr Gly Lys Asn Asp Arg Pro
                165                 170                 175     
Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Thr Ser Gly Asn Thr Ala
            180                 185                 190         
Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr
        195                 200                 205             
Xaa
    

<210> 255
<211> 228
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V18 scFv

<400> 255
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Val Leu Thr Gln Pro Pro
        115                 120                 125             
Ser Val Ser Val Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly
    130                 135                 140                 
Asn Asn Leu Gly Ser Lys Asn Val His Trp Tyr Gln Gln Lys Pro Gly
145                 150                 155                 160 
Gln Ala Pro Val Leu Val Ile Tyr Asp Asp Asp Asn Arg Pro Ser Gly
                165                 170                 175     
Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu
            180                 185                 190         
Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln
        195                 200                 205             
Val Trp Asp Ser Ser Ser Arg His Val Val Phe Gly Gly Gly Thr Lys
    210                 215                 220                 
Leu Thr Val Leu
225             


<210> 256
<211> 232
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 40 scFv

<400> 256
Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gln Pro Val Leu Thr Gln
        115                 120                 125             
Pro His Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys
    130                 135                 140                 
Thr Arg Ser Ser Gly Asn Ile Ala Ser Asn Phe Val Gln Trp Tyr Gln
145                 150                 155                 160 
Arg Arg Pro Asp Gly Ala Thr Thr Asn Val Ile Tyr Glu Asp Thr Gln
                165                 170                 175     
Arg Pro Ser Gly Val Ser Gly Arg Phe Ser Gly Ser Ile Asp Arg Ser
            180                 185                 190         
Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Arg Ala Glu Asp Glu
        195                 200                 205             
Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Arg Asn Leu Met Phe Gly
    210                 215                 220                 
Gly Gly Thr Lys Val Thr Val Leu
225                 230         


<210> 257
<211> 232
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 40 scFv

<400> 257
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gln Pro Val Leu Thr Gln
        115                 120                 125             
Pro His Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys
    130                 135                 140                 
Thr Arg Ser Ser Gly Asn Ile Ala Ser Asn Phe Val Gln Trp Tyr Gln
145                 150                 155                 160 
Arg Arg Pro Asp Gly Ala Thr Thr Asn Val Ile Tyr Glu Asp Thr Gln
                165                 170                 175     
Arg Pro Ser Gly Val Ser Gly Arg Phe Ser Gly Ser Ile Asp Arg Ser
            180                 185                 190         
Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Arg Ala Glu Asp Glu
        195                 200                 205             
Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Arg Asn Leu Met Phe Gly
    210                 215                 220                 
Gly Gly Thr Lys Val Thr Val Leu
225                 230         


<210> 258
<211> 229
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 350 scFv


<400> 258
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Arg Ser Thr Asp His Ala Asp Tyr Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr
65                  70                  75                  80  
Leu Gln Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Val Ser Asn Tyr Glu Tyr Tyr Phe Asp Tyr Trp Ala Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Gln Pro Val Leu Thr Gln Pro His Ser
        115                 120                 125             
Val Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr Arg Ser
    130                 135                 140                 
Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln Trp Tyr Gln Gln Arg Pro
145                 150                 155                 160 
Gly Ser Ala Pro Thr Thr Val Ile Tyr Glu Asp Asn Gln Arg Pro Ser
                165                 170                 175     
Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn Ser
            180                 185                 190         
Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr
        195                 200                 205             
Tyr Cys Gln Ser Tyr Asp Ser Ser Asn His Val Phe Gly Thr Gly Thr
    210                 215                 220                 
Lys Leu Thr Val Leu
225                 


<210> 259
<211> 229
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 20 scFv

<400> 259
Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Ser Gln Gly Thr Leu Val Thr Val Ser Ser Asn Ile Gln Met Thr Gln
        115                 120                 125             
Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr
    130                 135                 140                 
Cys Arg Ala Ser Gln Ser Ile Asn Lys Trp Leu Ala Trp Tyr Gln Gln
145                 150                 155                 160 
Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile His Asp Ala Ser Thr Leu
                165                 170                 175     
Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu
            180                 185                 190         
Phe Thr Leu Thr Ile Ser Ser Leu His Pro Asp Asp Ser Ala Thr Tyr
        195                 200                 205             
Tyr Cys Gln Gln Leu Lys Ser Pro Pro Ala Gln Phe Gly Glu Gly Thr
    210                 215                 220                 
Lys Leu Glu Ile Lys
225                 


<210> 260
<211> 229
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 20 scFv

<400> 260
Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Ser Gln Gly Thr Leu Val Thr Val Ser Ser Asn Ile Gln Met Thr Gln
        115                 120                 125             
Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr
    130                 135                 140                 
Cys Arg Ala Ser Gln Ser Ile Asn Lys Trp Leu Ala Trp Tyr Gln Gln
145                 150                 155                 160 
Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile His Asp Ala Ser Thr Leu
                165                 170                 175     
Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu
            180                 185                 190         
Phe Thr Leu Thr Ile Ser Ser Leu His Pro Asp Asp Ser Ala Thr Tyr
        195                 200                 205             
Tyr Cys Gln Gln Leu Lys Ser Arg Pro Leu Ser Phe Gly Glu Gly Thr
    210                 215                 220                 
Lys Leu Glu Ile Lys
225                 


<210> 261
<211> 229
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 20 scFv

<400> 261
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Ser Gln Gly Thr Leu Val Thr Val Ser Ser Asn Ile Gln Met Thr Gln
        115                 120                 125             
Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr
    130                 135                 140                 
Cys Arg Ala Ser Gln Ser Ile Asn Lys Trp Leu Ala Trp Tyr Gln Gln
145                 150                 155                 160 
Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile His Asp Ala Ser Thr Leu
                165                 170                 175     
Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu
            180                 185                 190         
Phe Thr Leu Thr Ile Ser Ser Leu His Pro Asp Asp Ser Ala Thr Tyr
        195                 200                 205             
Tyr Cys Gln Gln Leu Lys Ser Pro Pro Ala Gln Phe Gly Glu Gly Thr
    210                 215                 220                 
Lys Leu Glu Ile Lys
225                 


<210> 262
<211> 229
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 20 scFv

<400> 262
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Ser Gln Gly Thr Leu Val Thr Val Ser Ser Asn Ile Gln Met Thr Gln
        115                 120                 125             
Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr
    130                 135                 140                 
Cys Arg Ala Ser Gln Ser Ile Asn Lys Trp Leu Ala Trp Tyr Gln Gln
145                 150                 155                 160 
Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile His Asp Ala Ser Thr Leu
                165                 170                 175     
Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu
            180                 185                 190         
Phe Thr Leu Thr Ile Ser Ser Leu His Pro Asp Asp Ser Ala Thr Tyr
        195                 200                 205             
Tyr Cys Gln Gln Leu Lys Ser Arg Pro Leu Ser Phe Gly Glu Gly Thr
    210                 215                 220                 
Lys Leu Glu Ile Lys
225                 


<210> 263
<211> 232
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 43 scFv

<400> 263
Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gln Ser Val Leu Thr Gln
        115                 120                 125             
Pro Ser Ser Val Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys
    130                 135                 140                 
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr Trp Tyr Gln
145                 150                 155                 160 
Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Arg Asn Asn Gln
                165                 170                 175     
Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr
            180                 185                 190         
Ser Ala Ser Leu Gly His Gln Trp Ala Pro Gly Pro Arg Met Arg Leu
        195                 200                 205             
Ile Ile Thr Ala Ala Trp Asp Asp Ser Leu Ser Gly Val Val Phe Gly
    210                 215                 220                 
Gly Gly Thr Lys Leu Thr Val Leu
225                 230         


<210> 264
<211> 232
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 43 scFv

<400> 264
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Phe Gly Arg Trp Ser Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110         
Ser Gln Gly Thr Leu Val Thr Val Ser Ser Gln Ser Val Leu Thr Gln
        115                 120                 125             
Pro Ser Ser Val Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys
    130                 135                 140                 
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr Trp Tyr Gln
145                 150                 155                 160 
Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Arg Asn Asn Gln
                165                 170                 175     
Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr
            180                 185                 190         
Ser Ala Ser Leu Gly His Gln Trp Ala Pro Gly Pro Arg Met Arg Leu
        195                 200                 205             
Ile Ile Thr Ala Ala Trp Asp Asp Ser Leu Ser Gly Val Val Phe Gly
    210                 215                 220                 
Gly Gly Thr Lys Leu Thr Val Leu
225                 230         


<210> 265
<211> 227
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 305 scFv

<400> 265
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Arg Ser Thr Asp His Ala Asp Tyr Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr
65                  70                  75                  80  
Leu Gln Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Val Ser Asn Tyr Glu Tyr Tyr Phe Asp Tyr Trp Ala Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Gln Ser Val Leu Thr Gln Pro Pro Ser
        115                 120                 125             
Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly Gly Asn
    130                 135                 140                 
Asn Ile Gly Ser Thr Ser Val His Trp Phe Gln Gln Lys Pro Gly Gln
145                 150                 155                 160 
Ala Pro Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile
                165                 170                 175     
Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr
            180                 185                 190         
Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val
        195                 200                 205             
Trp Asp Asn Asp Ser Asp His Arg Val Phe Gly Gly Gly Thr Lys Leu
    210                 215                 220                 
Thr Val Leu
225         


<210> 266
<211> 229
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 366 scFv

<400> 266
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Arg Ser Thr Asp His Ala Asp Tyr Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr
65                  70                  75                  80  
Leu Gln Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Val Ser Asn Tyr Glu Tyr Tyr Phe Asp Tyr Trp Ala Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Gln Ser Val Leu Thr Gln Pro Pro Ser
        115                 120                 125             
Val Pro Gly Thr Pro Gly Gln Arg Val Thr Ile Thr Cys Ser Gly Ser
    130                 135                 140                 
Arg Phe Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro
145                 150                 155                 160 
Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser
                165                 170                 175     
Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser
            180                 185                 190         
Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys
        195                 200                 205             
Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val Phe Gly Thr Gly Thr
    210                 215                 220                 
Lys Leu Thr Val Leu
225                 


<210> 267
<211> 232
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 461 scFv

<220> 
<221> VARIANT        
<222> 194
<223> Xaa = any amino acid

<400> 267
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30          
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Lys Asp Phe Glu Val Arg Glu Ala His Leu Ser Tyr Phe
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gln Ser Val
        115                 120                 125             
Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg
    130                 135                 140                 
Ile Thr Cys Gly Gly Asn Arg Ile Gly Thr Lys Ala Val His Trp Tyr
145                 150                 155                 160 
Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Val Arg Asp Asp Thr
                165                 170                 175     
Asp Arg Pro Ser Gly Ser Leu Arg Asp Ser Leu Ala Pro Thr Leu Gly
            180                 185                 190         
Thr Xaa Ala Thr Leu Thr Ile Ser Gly Val Glu Ala Gly Asp Glu Ala
        195                 200                 205             
Asp Tyr Tyr Gln Val Trp Asp Ser Ser Ser Asp His Arg Val Phe Gly
    210                 215                 220                 
Gly Gly Thr Lys Leu Thr Val Leu
225                 230         


<210> 268
<211> 232
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 461 scFv

<220> 
<221> VARIANT        
<222> 194
<223> Xaa = any amino acid

<400> 268
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30          
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Lys Asp Phe Glu Val Arg Glu Ala His Leu Ser Tyr Phe
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gln Ser Val
        115                 120                 125             
Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg
    130                 135                 140                 
Ile Thr Cys Gly Gly Asn Arg Ile Gly Thr Lys Ala Val His Trp Tyr
145                 150                 155                 160 
Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Val Arg Asp Asp Thr
                165                 170                 175     
Asp Arg Pro Ser Gly Ser Leu Arg Asp Ser Leu Ala Pro Thr Leu Gly
            180                 185                 190         
Thr Xaa Ala Thr Leu Thr Ile Ser Gly Val Glu Ala Gly Asp Glu Ala
        195                 200                 205             
Asp Tyr Tyr Gln Val Trp Asp Ser Ser Ser Asp His Arg Val Phe Gly
    210                 215                 220                 
Gly Gly Thr Lys Leu Thr Val Leu
225                 230         

  
<210> 269
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 83, 83B CDR-H1

<400> 269
Gly Tyr Thr Phe Thr Ser Tyr
 1               5          


<210> 270
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 298, V70, Clone 350, 305, 366, 461, V68,
      V102, V181 CDR-H1

<400> 270
Gly Phe Thr Phe Gly Asp Tyr
 1               5          


<210> 271
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 48, V353, Clone 7, 81, 16, V18, 40, 20, 43,
      V9,  V163, V95, V312, V357, V397
       CDR-H1

<400> 271
Gly Phe Thr Phe Ser Asn Ala
 1               5          


<210> 272
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V71 CDR-H1

<400> 272
Gly Phe Thr Phe Ser Thr Ser
 1               5          


<210> 273
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V86, V278, V282, V365, V420, V336 CDR-H1

<400> 273
Gly Phe Thr Phe Ser Ser Tyr
 1               5          


<210> 274
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = any amino acid

<220> 
<223> Clone 65 CDR-H1

<400> 274
Gly Phe Thr Phe Gln Xaa Arg
 1               5          


<210> 275
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V128 CDR-H1

<400> 275
Gly Phe Thr Phe Asp Thr Phe
 1               5          


<210> 276
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V224 CDR-H1

<400> 276
Gly Phe Thr Phe Ile Asn Ala
 1               5          


<210> 277
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V316 CDR-H1

<400> 277
Gly Leu Thr Phe Ser Arg Thr
 1               5          


<210> 278
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V331, V345 CDR-H1

<400> 278
Gly Gly Ser Phe Ser Gly Tyr
 1               5          


<210> 279
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V355 CDR-H1

<400> 279
Gly Gly Thr Phe Ser Ser Tyr
 1               5          


<210> 280
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 65 CDR-H1

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = any amino acid

<400> 280
Gly Phe Thr Phe Gln Xaa Arg Leu Asp Glu
 1               5                  10  


<210> 281
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V71 CDR-H1

<400> 281
Gly Phe Thr Phe Ser Thr Ser Ala Met Ser
 1               5                  10  


<210> 282
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 86, V278, V365 CDR-H1

<400> 282
Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser
 1               5                  10  


<210> 283
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V128 CDR-H1

<400> 283
Gly Phe Thr Phe Asp Thr Phe Trp Met Ser
 1               5                  10  


<210> 284
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V224 CDR-H1

<400> 284
Gly Phe Thr Phe Ile Asn Ala Trp Met Ser
 1               5                  10  


<210> 285
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V316 CDR-H1

<400> 285
Gly Leu Thr Phe Ser Arg Thr Trp Met Ser
 1               5                  10  


<210> 286
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V331 CDR-H1

<400> 286
Gly Gly Ser Phe Ser Gly Tyr Tyr Trp Ser
 1               5                  10  


<210> 287
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V355 CDR-H1

<400> 287
Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser
 1               5                  10  


<210> 288
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V282, V420 CDR-H1

<400> 288
Gly Phe Thr Phe Ser Ser Tyr Trp Met Ser
 1               5                  10  


<210> 289
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V345 CDR-H1

<400> 289
Gly Gly Ser Phe Ser Gly Tyr Tyr Trp Ser
 1               5                  10  


<210> 290
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V336 CDR-H1

<400> 290
Gly Phe Thr Phe Ser Ser Tyr Ala Met His
 1               5                  10  


<210> 291
<211> 8
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V353 , V48, V81, V16, V65, V18, V40 , V20,
      V43, V224, V163, V95, V312,  V357, V397 CDR-H2

<400> 291
Lys Ser Lys Thr Asp Gly Gly Thr
 1               5              


<210> 292
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V298, V350, V305, V366 CDR-H2

<400> 292
Ser Gly Ser Gly Arg Ser
 1               5      


<210> 293
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V83 CDR-H2

<400> 293
Asn Pro Ser Gly Gly Ser
 1               5      


<210> 294
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V83B CDR-H2

<400> 294
Asn Pro Asn Gly Gly Ser
 1               5      


<210> 295
<211> 8
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 7   CDR-H2

<400> 295
Arg Ser Lys Thr Asp Gly Gly Thr
 1               5              


<210> 296
<211> 8
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V68, V102 CDR-H2

<400> 296
Arg Ser Lys Ala Tyr Gly Gly Thr
 1               5              


<210> 297
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V71 CDR-H2

<400> 297
Ser Thr Asp Gly Ala Thr
 1               5      


<210> 298
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V86, V278, V365 CDR-H2

<400> 298
Ser Gly Ser Gly Gly Ser
 1               5      


<210> 299
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V316  CDR-H2

<400> 299
Asn Asp Asp Gly Ser Glu
 1               5      


<210> 300
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V331, V345 CDR-H2

<400> 300
Asn His Ser Gly Ser
 1               5  


<210> 301
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V355  CDR-H2

<400> 301
Ile Pro Ile Phe Gly Thr
 1               5      


<210> 302
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V282 , V420 CDR-H2

<400> 302
Lys Gln Asp Gly Ser Glu
 1               5      


<210> 303
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V336 CDR-H2

<400> 303
Ser Tyr Asp Gly Ser
 1               5  


<210> 304
<211> 12
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V353 , V48, V81, V16, V65, V18, V40, V20,
      V43, V224, V163, V95, V312, V357, V397 CDR-H2

<400> 304
Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp
 1               5                  10          


<210> 305
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 298 , V350, V305, V366 CDR-H2

<400> 305
Ser Ile Ser Gly Ser Gly Arg Ser Thr Asp
 1               5                  10  


<210> 306
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V83 CDR-H2

<400> 306
Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser
 1               5                  10  


<210> 307
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V83B CDR-H2

<400> 307
Ile Ile Asn Pro Asn Gly Gly Ser Thr Ser
 1               5                  10  


<210> 308
<211> 12
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 7 CDR-H2

<400> 308
Arg Ile Arg Ser Lys Thr Asp Gly Gly Thr Thr Asp
 1               5                  10          


<210> 309
<211> 12
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V68, V102, V181 CDR-H2

<400> 309
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu
 1               5                  10          


<210> 310
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V71 CDR-H2

<400> 310
Thr Ile Ser Thr Asp Gly Ala Thr Thr Trp
 1               5                  10  


<210> 311
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V86, V278, V365 CDR-H2

<400> 311
Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr
 1               5                  10  


<210> 312
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V316 CDR-H2

<400> 312
Ser Ile Asn Asp Asp Gly Ser Glu Lys Tyr
 1               5                  10  


<210> 313
<211> 9
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V331 CDR-H2

<400> 313
Lys Ile Asn His Ser Gly Ser Thr Asn
 1               5                  


<210> 314
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V355 CDR-H2

<400> 314
Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn
 1               5                  10  


<210> 315
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V282, V420 CDR-H2

<400> 315
Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr
 1               5                  10  


<210> 316
<211> 9
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V345 CDR-H2

<400> 316
Glu Ile Asn His Ser Gly Ser Thr Asn
 1               5                  


<210> 317
<211> 9
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone V336 CDR-H2

<400> 317
Val Ile Ser Tyr Asp Gly Ser Thr Asn
 1               5                  


<210> 318
<211> 19
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone 7 CDR-H2

<400> 318
Arg Ile Arg Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala Leu
 1               5                  10                  15      
Val Lys Gly
            

