                         SEQUENCE LISTING

<110>  The Board of Trustees-Leland Stanford Junior University
       Cochran, Jennifer R
       Leung, Cheuk Lun
       Shiven, Kapur
       Blumenkranz, Mark S
 
<120>  Hybrid Chimera Polypeptides as Dual Inhibitors of Vascular 
       Endothelial Growth Factor Receptor and Platelet-derived Growth 
       Factor Receptor

<130>  STAN-1175WO

<140>  US2016/013674
<141>  2016-01-15

<150>  US 62/104,612
<151>  2015-01-16

<150>  US 62/263,518
<151>  2015-12-04

<160>  1     

<170>  PatentIn version 3.5

<210> 1
<211> 109
<212> PRT
<213> H. sapiens
PDGF reference sequence
<400> 1
Ser Leu Gly Ser Leu Thr Ile Ala Glu Pro Ala Met Ile Ala Glu Cys 
 1               5                  10                  15      
Lys Thr Arg Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile Asp Arg 
            20                  25                  30          
Thr Asn Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val Gln Arg 
        35                  40                  45              
Cys Ser Gly Cys Cys Asn Asn Arg Asn Val Gln Cys Arg Pro Thr Gln 
    50                  55                  60                  
Val Gln Leu Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val Arg Lys 
65                  70                  75                  80  
Lys Pro Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His Leu Ala 
                85                  90                  95      
Cys Lys Cys Glu Thr Val Ala Ala Ala Arg Pro Val Thr
            100                 105
        


<210> 2
<211> 109
<212> PRT
<213> H. sapiens
VEGF reference sequence
<400> 2
Ala Pro Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys 
 1               5                  10                  15      
Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu 
            20                  25                  30          
Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys 
        35                  40                  45              
Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu 
    50                  55                  60                  
Gly Leu Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile 
65                  70                  75                  80  
Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe 
                85                  90                  95      
Leu Gln His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp
            100                 105
    


<210> 3
<211> 209
<212> PRT
<213> H. sapiens
PV1 hybrid
<400> 3
Ile Ala Glu Pro Ala Met Ile Ala Glu Cys Lys Thr Arg Glu Thr Leu
 1               5                  10                  15      
Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys
            20                  25                  30          
Pro Ser Cys Val Pro Leu Met Arg Cys Ser Gly Cys Cys Asn Asn Arg
        35                  40                  45              
Asn Val Gln Cys Arg Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile
    50                  55                  60                  
Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe
65                  70                  75                  80  
Leu Gln His Leu Ala Cys Lys Cys Glu Thr Val Ala Ala Gly Ser Thr
                85                  90                  95      
Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly Glu Val Val Lys Phe
            100                 105                 110         
Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Thr Glu Val Phe
        115                 120                 125             
Glu Ile Ser Arg Arg Leu Ile Asp Arg Thr Asn Ala Asn Phe Leu Val
    130                 135                 140                 
Trp Pro Pro Cys Val Glu Val Gln Arg Cys Gly Gly Cys Cys Asn Asp
145                 150                 155                 160 
Glu Gly Leu Glu Cys Val Pro Thr Gln Val Gln Leu Arg Pro Val Gln
                165                 170                 175     
Val Arg Lys Ile Glu Ile Val Arg Lys Lys Pro Ile Phe Lys Lys Ala
            180                 185                 190         
Thr Val Thr Leu Glu Asp His Asn Lys Cys Glu Cys Arg Pro Lys Lys
        195                 200                 205             
Asp
    


<210> 4
<211> 209
<212> PRT
<213> H. sapiens
PV2 hybrid
<400> 4
Ile Ala Glu Pro Ala Met Ile Ala Glu Cys Lys Thr Arg Thr Glu Leu
 1               5                  10                  15      
Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys
            20                  25                  30          
Pro Ser Cys Val Pro Leu Met Arg Cys Ser Gly Cys Cys Asn Asn Arg
        35                  40                  45              
Asn Val Gln Cys Arg Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile
    50                  55                  60                  
Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe
65                  70                  75                  80  
Leu Gln His Leu Ala Cys Lys Cys Glu Thr Val Ala Ala Gly Ser Thr
                85                  90                  95      
Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly Glu Val Val Lys Phe
            100                 105                 110         
Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Val Phe
        115                 120                 125             
Glu Ile Ser Arg Arg Leu Ile Asp Arg Thr Asn Ala Asn Phe Leu Val
    130                 135                 140                 
Trp Pro Pro Cys Val Glu Val Gln Arg Cys Gly Gly Cys Cys Asn Asp
145                 150                 155                 160 
Glu Gly Leu Glu Cys Val Pro Thr Gln Val Gln Leu Arg Pro Val Gln
                165                 170                 175     
Val Arg Lys Ile Glu Ile Val Arg Lys Lys Pro Ile Phe Lys Lys Ala
            180                 185                 190         
Thr Val Thr Leu Glu Asp His Asn Lys Cys Glu Cys Arg Pro Lys Lys
        195                 200                 205             
Asp
    


<210> 5
<211> 209
<212> PRT
<213> H. sapiens
PV3 hybrid
<400> 5
Ile Ala Glu Pro Ala Met Ile Ala Glu Cys Lys Thr Arg Thr Glu Val
 1               5                  10                  15      
Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys
            20                  25                  30          
Pro Ser Cys Val Pro Leu Met Arg Cys Ser Gly Cys Cys Asn Asn Arg
        35                  40                  45              
Asn Val Gln Cys Arg Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile
    50                  55                  60                  
Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe
65                  70                  75                  80  
Leu Gln His Leu Ala Cys Lys Cys Glu Thr Val Ala Ala Gly Ser Thr
                85                  90                  95      
Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly Glu Val Val Lys Phe
            100                 105                 110         
Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Phe
        115                 120                 125             
Glu Ile Ser Arg Arg Leu Ile Asp Arg Thr Asn Ala Asn Phe Leu Val
    130                 135                 140                 
Trp Pro Pro Cys Val Glu Val Gln Arg Cys Gly Gly Cys Cys Asn Asp
145                 150                 155                 160 
Glu Gly Leu Glu Cys Val Pro Thr Gln Val Gln Leu Arg Pro Val Gln
                165                 170                 175     
Val Arg Lys Ile Glu Ile Val Arg Lys Lys Pro Ile Phe Lys Lys Ala
            180                 185                 190         
Thr Val Thr Leu Glu Asp His Asn Lys Cys Glu Cys Arg Pro Lys Lys
        195                 200                 205             
Asp
    


<210> 6
<211> 209
<212> PRT
<213> H. sapiens
PV4 hybrid
<400> 6
Ile Ala Glu Pro Ala Met Ile Ala Glu Cys Lys Thr Arg Thr Glu Val
 1               5                  10                  15      
Phe Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys
            20                  25                  30          
Pro Ser Cys Val Pro Leu Met Arg Cys Ser Gly Cys Cys Asn Asn Arg
        35                  40                  45              
Asn Val Gln Cys Arg Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile
    50                  55                  60                  
Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe
65                  70                  75                  80  
Leu Gln His Leu Ala Cys Lys Cys Glu Thr Val Ala Ala Gly Ser Thr
                85                  90                  95      
Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly Glu Val Val Lys Phe
            100                 105                 110         
Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val
        115                 120                 125             
Glu Ile Ser Arg Arg Leu Ile Asp Arg Thr Asn Ala Asn Phe Leu Val
    130                 135                 140                 
Trp Pro Pro Cys Val Glu Val Gln Arg Cys Gly Gly Cys Cys Asn Asp
145                 150                 155                 160 
Glu Gly Leu Glu Cys Val Pro Thr Gln Val Gln Leu Arg Pro Val Gln
                165                 170                 175     
Val Arg Lys Ile Glu Ile Val Arg Lys Lys Pro Ile Phe Lys Lys Ala
            180                 185                 190         
Thr Val Thr Leu Glu Asp His Asn Lys Cys Glu Cys Arg Pro Lys Lys
        195                 200                 205             
Asp
    


<210> 7
<211> 209
<212> PRT
<213> H. sapiens
PV5 hybrid
<400> 7
Ile Ala Glu Pro Ala Met Ile Ala Glu Cys Lys Thr Arg Thr Glu Val
 1               5                  10                  15      
Phe Glu Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys
            20                  25                  30          
Pro Ser Cys Val Pro Leu Met Arg Cys Ser Gly Cys Cys Asn Asn Arg
        35                  40                  45              
Asn Val Gln Cys Arg Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile
    50                  55                  60                  
Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe
65                  70                  75                  80  
Leu Gln His Leu Ala Cys Lys Cys Glu Thr Val Ala Ala Gly Ser Thr
                85                  90                  95      
Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly Glu Val Val Lys Phe
            100                 105                 110         
Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val
        115                 120                 125             
Asp Ile Ser Arg Arg Leu Ile Asp Arg Thr Asn Ala Asn Phe Leu Val
    130                 135                 140                 
Trp Pro Pro Cys Val Glu Val Gln Arg Cys Gly Gly Cys Cys Asn Asp
145                 150                 155                 160 
Glu Gly Leu Glu Cys Val Pro Thr Gln Val Gln Leu Arg Pro Val Gln
                165                 170                 175     
Val Arg Lys Ile Glu Ile Val Arg Lys Lys Pro Ile Phe Lys Lys Ala
            180                 185                 190         
Thr Val Thr Leu Glu Asp His Asn Lys Cys Glu Cys Arg Pro Lys Lys
        195                 200                 205             
Asp
    


<210> 8
<211> 93
<212> PRT
<213> H. sapiens
PV6 hybrid chain 1
<400> 8
Ile Ala Glu Pro Ala Met Ile Ala Glu Cys His Pro Ile Glu Thr Leu
 1               5                  10                  15      
Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys
            20                  25                  30          
Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asn Arg
        35                  40                  45              
Asn Val Gln Cys Arg Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile
    50                  55                  60                  
Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe
65                  70                  75                  80  
Leu Gln His Asn Lys Cys Lys Cys Glu Thr Val Ala Ala
                85                  90              


<210> 9
<211> 102
<212> PRT
<213> H. sapiens
PV6 hybrid chain 2
<400> 9
Glu Val Val Lys Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys Lys Thr
 1               5                  10                  15      
Arg Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile Asp Arg Thr Asn
            20                  25                  30          
Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val Gln Arg Cys Ser
        35                  40                  45              
Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro Thr Gln Val Gln
    50                  55                  60                  
Leu Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val Arg Lys Lys Pro
65                  70                  75                  80  
Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His Leu Ala Cys Lys
                85                  90                  95      
Cys Arg Pro Lys Lys Asp
            100         


<210> 10
<211> 93
<212> PRT
<213> H. sapiens
PV7 hybrid chain 1
<400> 10
Ile Ala Glu Pro Ala Met Ile Ala Glu Cys Lys Thr Arg Glu Thr Leu
 1               5                  10                  15      
Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys
            20                  25                  30          
Pro Ser Cys Val Pro Leu Met Arg Cys Ser Gly Cys Cys Asn Asn Arg
        35                  40                  45              
Asn Val Gln Cys Arg Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile
    50                  55                  60                  
Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe
65                  70                  75                  80  
Leu Gln His Asn Lys Cys Lys Cys Glu Thr Val Ala Ala
                85                  90              


<210> 11
<211> 102
<212> PRT
<213> H. sapiens
PV7 hybrid chain 2
<400> 11
Glu Val Val Lys Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro
 1               5                  10                  15      
Ile Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile Asp Arg Thr Asn
            20                  25                  30          
Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val Gln Arg Cys Gly
        35                  40                  45              
Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro Thr Gln Val Gln
    50                  55                  60                  
Leu Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val Arg Lys Lys Pro
65                  70                  75                  80  
Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His Leu Ala Cys Glu
                85                  90                  95      
Cys Arg Pro Lys Lys Asp
            100         


<210> 12
<211> 93
<212> PRT
<213> H. sapiens
PV8 hybrid chain 1
<400> 12
Ile Ala Glu Pro Ala Met Ile Ala Glu Cys Lys Thr Ile Glu Thr Leu
 1               5                  10                  15      
Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys
            20                  25                  30          
Pro Ser Cys Val Pro Leu Met Arg Cys Ser Gly Cys Cys Asn Asn Arg
        35                  40                  45              
Asn Val Gln Cys Arg Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile
    50                  55                  60                  
Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe
65                  70                  75                  80  
Leu Gln His Leu Ala Cys Lys Cys Glu Thr Val Ala Ala
                85                  90              


<210> 13
<211> 102
<212> PRT
<213> H. sapiens
PV8 hybrid chain 2
<400> 13
Glu Val Val Lys Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro
 1               5                  10                  15      
Arg Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile Asp Arg Thr Asn
            20                  25                  30          
Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val Gln Arg Cys Gly
        35                  40                  45              
Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro Thr Gln Val Gln
    50                  55                  60                  
Leu Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val Arg Lys Lys Pro
65                  70                  75                  80  
Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His Asn Lys Cys Glu
                85                  90                  95      
Cys Arg Pro Lys Lys Asp
            100         


<210> 14
<211> 93
<212> PRT
<213> H. sapiens
PV K87R hybrid chain 1
<400> 14
Ile Ala Glu Pro Ala Met Ile Ala Glu Cys His Pro Ile Glu Thr Leu
 1               5                  10                  15      
Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys
            20                  25                  30          
Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asn Arg
        35                  40                  45              
Asn Val Gln Cys Arg Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile
    50                  55                  60                  
Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe
65                  70                  75                  80  
Leu Gln His Asn Lys Cys Arg Cys Glu Thr Val Ala Ala
                85                  90              


<210> 15
<211> 102
<212> PRT
<213> H. sapiens
PV I182F hybrid chain 2
<400> 15
Glu Val Val Lys Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys Lys Thr
 1               5                  10                  15      
Arg Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile Asp Arg Thr Asn
            20                  25                  30          
Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val Gln Arg Cys Ser
        35                  40                  45              
Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro Thr Gln Val Gln
    50                  55                  60                  
Leu Arg Pro Val Gln Val Arg Lys Ile Glu Phe Val Arg Lys Lys Pro
65                  70                  75                  80  
Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His Leu Ala Cys Glu
                85                  90                  95      
Cys Arg Pro Lys Lys Asp
            100         


<210> 16
<211> 93
<212> PRT
<213> H. sapiens
3-3 hybrid chain 1
<400> 16
Ile Ala Glu Pro Ala Val Ile Ala Glu Cys His Pro Ile Glu Thr Leu
 1               5                  10                  15      
Val Asp Ile Leu Gln Glu Tyr Pro Asp Glu Ile Gly Tyr Ile Phe Lys
            20                  25                  30          
Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asn Arg
        35                  40                  45              
Asn Val Gln Cys Arg Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile
    50                  55                  60                  
Met Arg Ile Lys Pro His Arg Gly Gln His Ile Gly Glu Met Ser Phe
65                  70                  75                  80  
Leu Gln His Asn Lys Cys Lys Cys Glu Thr Val Ala Ala
                85                  90              


<210> 17
<211> 102
<212> PRT
<213> H. sapiens
3-3 hybrid chain 2
<400> 17
Glu Val Val Lys Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys Lys Thr
 1               5                  10                  15      
Arg Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile Asp Arg Thr Asn
            20                  25                  30          
Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val Gln Arg Cys Ser
        35                  40                  45              
Gly Cys Cys Asn His Glu Gly Leu Glu Cys Val Pro Thr Gln Val Gln
    50                  55                  60                  
Leu Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val Arg Lys Lys Pro
65                  70                  75                  80  
Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His Leu Ala Cys Glu
                85                  90                  95      
Cys Arg Pro Lys Lys Asp
            100         


<210> 18
<211> 93
<212> PRT
<213> H. sapiens
4-22 hybrid chain 1
<400> 18
Ile Ala Glu Pro Ala Met Ile Ala Glu Cys His Pro Ile Glu Thr Leu
 1               5                  10                  15      
Val Asp Ile Leu Gln Glu Tyr Pro Asp Glu Ile Gly Tyr Ile Phe Lys
            20                  25                  30          
Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asn Arg
        35                  40                  45              
Asn Val Gln Cys Arg Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile
    50                  55                  60                  
Met Arg Ile Lys Pro His Arg Gly Gln His Ile Gly Glu Met Ser Phe
65                  70                  75                  80  
Leu Gln His Asn Lys Cys Lys Cys Glu Thr Val Ala Ala
                85                  90              


<210> 19
<211> 102
<212> PRT
<213> H. sapiens
4-22 hybrid chain 2
<400> 19
Glu Val Val Lys Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys Lys Thr
 1               5                  10                  15      
Arg Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile Asp Arg Thr Asn
            20                  25                  30          
Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val Gln Arg Cys Ser
        35                  40                  45              
Gly Cys Cys Asn His Glu Gly Leu Glu Cys Val Pro Thr Gln Val Gln
    50                  55                  60                  
Leu Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val Arg Lys Lys Pro
65                  70                  75                  80  
Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His Leu Ala Cys Glu
                85                  90                  95      
Cys Arg Pro Lys Lys Asp
            100         


<210> 20
<211> 93
<212> PRT
<213> H. sapiens
5-5 hybrid chain 1
<400> 20
Ile Ala Glu Pro Ala Val Ile Ala Glu Cys His Pro Ile Glu Thr Leu
 1               5                  10                  15      
Val Asp Ile Leu Gln Glu Tyr Pro Asp Glu Ile Gly Tyr Ile Phe Lys
            20                  25                  30          
Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asn Arg
        35                  40                  45              
Asn Val Gln Cys Arg Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile
    50                  55                  60                  
Met Arg Ile Lys Pro His Arg Gly Gln His Ile Gly Glu Met Ser Phe
65                  70                  75                  80  
Leu Gln His Asn Lys Cys Lys Cys Glu Thr Val Ala Ala
                85                  90              


<210> 21
<211> 102
<212> PRT
<213> H. sapiens
5-5 hybrid chain 2
<400> 21
Glu Val Val Lys Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys Lys Thr
 1               5                  10                  15      
Arg Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile Asp Arg Thr Asn
            20                  25                  30          
Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val Gln Arg Cys Ser
        35                  40                  45              
Gly Cys Cys Asn His Glu Gly Leu Glu Cys Val Pro Thr Gln Val Gln
    50                  55                  60                  
Leu Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val Arg Lys Lys Pro
65                  70                  75                  80  
Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His Leu Ala Cys Glu
                85                  90                  95      
Cys Arg Pro Lys Lys Val
            100     


<210> 22
<211> 93
<212> PRT
<213> H. sapiens
4-22 RF hybrid chain 1
<400> 22
Ile Ala Glu Pro Ala Met Ile Ala Glu Cys His Pro Ile Glu Thr Leu
 1               5                  10                  15      
Val Asp Ile Leu Gln Glu Tyr Pro Asp Glu Ile Gly Tyr Ile Phe Lys
            20                  25                  30          
Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asn Arg
        35                  40                  45              
Asn Val Gln Cys Arg Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile
    50                  55                  60                  
Met Arg Ile Lys Pro His Arg Gly Gln His Ile Gly Glu Met Ser Phe
65                  70                  75                  80  
Leu Gln His Asn Lys Cys Arg Cys Glu Thr Val Ala Ala
                85                  90              


<210> 23
<211> 102
<212> PRT
<213> H. sapiens
4-22 RF hybrid chain 2
<400> 23
Glu Val Val Lys Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys Lys Thr
 1               5                  10                  15      
Arg Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile Asp Arg Thr Asn
            20                  25                  30          
Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val Gln Arg Cys Ser
        35                  40                  45              
Gly Cys Cys Asn His Glu Gly Leu Glu Cys Val Pro Thr Gln Val Gln
    50                  55                  60                  
Leu Arg Pro Val Gln Val Arg Lys Ile Glu Phe Val Arg Lys Lys Pro
65                  70                  75                  80  
Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His Leu Ala Cys Glu
                85                  90                  95      
Cys Arg Pro Lys Lys Asp
            100         


<210> 24
<211> 93
<212> PRT
<213> H. sapiens
PV R32A hybrid chain 1
<400> 24
Ile Ala Glu Pro Ala Met Ile Ala Glu Cys His Pro Ile Glu Thr Leu
 1               5                  10                  15      
Val Asp Ile Leu Gln Glu Tyr Pro Asp Glu Ile Gly Tyr Ile Phe Lys
            20                  25                  30          
Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asn Arg
        35                  40                  45              
Asn Val Gln Cys Arg Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile
    50                  55                  60                  
Met Arg Ile Lys Pro His Arg Gly Gln His Ile Gly Glu Met Ser Phe
65                  70                  75                  80  
Leu Gln His Asn Lys Cys Arg Cys Glu Thr Val Ala Ala
                85                  90              


<210> 25
<211> 102
<212> PRT
<213> H. sapiens
PV R32A hybrid chain 2
<400> 25
Glu Val Val Lys Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys Lys Thr
 1               5                  10                  15      
Arg Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile Asp Ala Thr Asn
            20                  25                  30          
Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val Gln Arg Cys Ser
        35                  40                  45              
Gly Cys Cys Asn His Glu Gly Leu Glu Cys Val Pro Thr Gln Val Gln
    50                  55                  60                  
Leu Arg Pro Val Gln Val Arg Lys Ile Glu Phe Val Arg Lys Lys Pro
65                  70                  75                  80  
Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His Leu Ala Cys Glu
                85                  90                  95      
Cys Arg Pro Lys Lys Asp
            100         

