                         SEQUENCE LISTING

<110>  TAKEDA VACCINES, INC.
       HAYNES, JOEL R.
       BENSON, EVELYN
 
<120>  Detection of Particle-Contained Reverse Transcriptase Activity

<130>  LIGO-027/01WO 306927-2285

<150>  US 62/104252
<151>  2015-01-16

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  10649
<212>  DNA
<213>  Dengue virus type 4 strain 814669

<400>  1
agttgttagt ctgtgtggac cgacaaggac agttccaaat cggaagcttg cttaacacag       60

ttctaacagt ttgtttgaat agagagcaga tctctggaaa aatgaaccaa cgaaaaaagg      120

tggttagacc acctttcaat atgctgaaac gcgagagaaa ccgcgtatca acccctcaag      180

ggttggtgaa gagattctca accggacttt tttctgggaa aggaccctta cggatggtgc      240

tagcattcat cacgtttttg cgagtccttt ccatcccacc aacagcaggg attctgaaga      300

gatggggaca gttgaagaaa aataaggcca tcaagatact gattggattc aggaaggaga      360

taggccgcat gctgaacatc ttgaacggga gaaaaaggtc aacgataaca ttgctgtgct      420

tgattcccac cgtaatggcg ttttccttgt caacaagaga tggcgaaccc ctcatgatag      480

tggcaaaaca tgaaaggggg agacctctct tgtttaagac aacagagggg atcaacaaat      540

gcactctcat tgccatggac ttgggtgaaa tgtgtgagga cactgtcacg tataaatgcc      600

ccctactggt caataccgaa cctgaagaca ttgattgctg gtgcaacctc acgtctacct      660

gggtcatgta tgggacatgc acccagagcg gagaacggag acgagagaag cgctcagtag      720

ctttaacacc acattcagga atgggattgg aaacaagagc tgagacatgg atgtcatcgg      780

aaggggcttg gaagcatgct cagagagtag agagctggat actcagaaac ccaggattcg      840

cgctcttggc aggatttatg gcttatatga ttgggcaaac aggaatccag cgaactgtct      900

tctttgtcct aatgatgctg gtcgccccat cctacggaat gcgatgcgta ggagtaggaa      960

acagagactt tgtggaagga gtctcaggtg gagcatgggt cgacctggtg ctagaacatg     1020

gaggatgcgt cacaaccatg gcccagggaa aaccaacctt ggattttgaa ctgactaaga     1080

caacagccaa ggaagtggct ctgttaagaa cctattgcat tgaagcctca atatcaaaca     1140

taactacggc aacaagatgt ccaacgcaag gagagcctta tctgaaagag gaacaggacc     1200

aacagtacat ttgccggaga gatgtggtag acagagggtg gggcaatggc tgtggcttgt     1260

ttggaaaagg aggagttgtg acatgtgcga agttttcatg ttcggggaag ataacaggca     1320

atttggtcca aattgagaac cttgaataca cagtggttgt aacagtccac aatggagaca     1380

cccatgcagt aggaaatgac acatccaatc atggagttac agccatgata actcccaggt     1440

caccatcggt ggaagtcaaa ttgccggact atggagaact aacactcgat tgtgaaccca     1500

ggtctggaat tgactttaat gagatgattc tgatgaaaat gaaaaagaaa acatggctcg     1560

tgcataagca atggtttttg gatctgcctc ttccatggac agcaggagca gacacatcag     1620

aggttcactg gaattacaaa gagagaatgg tgacatttaa ggttcctcat gccaagagac     1680

aggatgtgac agtgctggga tctcaggaag gagccatgca ttctgccctc gctggagcca     1740

cagaagtgga ctccggtgat ggaaatcaca tgtttgcagg acatcttaag tgcaaagtcc     1800

gtatggagaa attgagaatc aagggaatgt catacacgat gtgttcagga aagttttcaa     1860

ttgacaaaga gatggcagaa acacagcatg ggacaacagt ggtgaaagtc aagtatgaag     1920

gtgctggagc tccgtgtaaa gtccccatag agataagaga tgtaaacaag gaaaaagtgg     1980

ttgggcgtat catctcatcc acccctttgg ctgagaatac caacagtgta accaacatag     2040

aattagaacc cccctttggg gacagctaca tagtgatagg tgttggaaac agcgcattaa     2100

cactccattg gttcaggaaa gggagttcca ttggcaagat gtttgagtcc acatacagag     2160

gtgcaaaacg aatggccatt ctaggtgaaa cagcttggga ttttggttcc gttggtggac     2220

tgttcacatc attgggaaag gctgtgcacc aggtttttgg aagtgtgtat acaaccatgt     2280

ttggaggagt ctcatggatg attagaatcc taattgggtt cttagtgttg tggattggca     2340

cgaactcaag gaacacttca atggctatga cgtgcatagc tgttggagga atcactctgt     2400

ttctgggctt cacagttcaa gcagacatgg gttgtgtggt gtcatggagt gggaaagaat     2460

tgaagtgtgg aagcggaatt tttgtggttg acaacgtgca cacttggaca gaacagtaca     2520

aatttcaacc agagtcccca gcgagactag cgtctgcaat attaaatgcc cacaaagatg     2580

gggtctgtgg aattagatca accacgaggc tggaaaatgt catgtggaag caaataacca     2640

acgagctaaa ctatgttctc tgggaaggag gacatgacct cactgtagtg gctggggatg     2700

tgaagggggt gttgaccaaa ggcaagagag cactcacacc cccagtgagt gatctgaaat     2760

attcatggaa gacatgggga aaagcaaaaa tcttcacccc agaagcaaga aatagcacat     2820

ttttaataga cggaccagac acctctgaat gccccaatga acgaagagca tggaactctc     2880

ttgaggtgga agactatgga tttggcatgt tcacgaccaa catatggatg aaattccgag     2940

aaggaagttc agaagtgtgt gaccacaggt taatgtcagc tgcaattaaa gatcagaaag     3000

ctgtgcatgc tgacatgggt tattggatag agagctcaaa aaaccagacc tggcagatag     3060

agaaagcatc tcttattgaa gtgaaaacat gtctgtggcc caagacccac acactgtgga     3120

gcaatggagt gctggaaagc cagatgctca ttccaaaatc atatgcgggc cctttttcac     3180

agcacaatta ccgccagggc tatgccacgc aaaccgtggg cccatggcac ttaggcaaat     3240

tagagataga ctttggagaa tgccccggaa caacagtcac aattcaggag gattgtgacc     3300

atagaggccc atctttgagg accaccactg catctggaaa actagtcacg caatggtgct     3360

gccgctcctg cacgatgcct cccttaaggt tcttgggaga agatgggtgc tggtatggga     3420

tggagattag gcccttgagt gaaaaagaag agaacatggt caaatcacag gtgacggccg     3480

gacagggcac atcagaaact ttttctatgg gtctgttgtg cctgaccttg tttgtggaag     3540

aatgcttgag gagaagagtc actaggaaac acatgatatt agttgtggtg atcactcttt     3600

gtgctatcat cctgggaggc ctcacatgga tggacttact acgagccctc atcatgttgg     3660

gggacactat gtctggtaga ataggaggac agatccacct agccatcatg gcagtgttca     3720

agatgtcacc aggatacgtg ctgggtgtgt ttttaaggaa actcacttca agagagacag     3780

cactaatggt aataggaatg gccatgacaa cggtgctttc aattccacat gaccttatgg     3840

aactcattga tggaatatca ctgggactaa ttttgctaaa aatagtaaca cagtttgaca     3900

acacccaagt gggaacctta gctctttcct tgactttcat aagatcaaca atgccattgg     3960

tcatggcttg gaggaccatt atggctgtgt tgtttgtggt cacactcatt cctttgtgca     4020

ggacaagctg tcttcaaaaa cagtctcatt gggtagaaat aacagcactc atcctaggag     4080

cccaagctct gccagtgtac ctaatgactc ttatgaaagg agcctcaaga agatcttggc     4140

ctcttaacga gggcataatg gctgtgggtt tagttagtct cttaggaagc gctcttttaa     4200

agaatgatgt ccctttagct ggcccaatgg tggcaggagg cttacttctg gcggcttacg     4260

tgatgagtgg tagctcagca gatctgtcac tagagaaggc cgccaatgtg cagtgggatg     4320

aaatggcaga cataacaggc tcaagcccaa tcatagaagt gaagcaggat gaagatggct     4380

ctttctccat acgggacgtc gaggaaacca atatgataac ccttttggtg aaactggcac     4440

tgataacagt gtcaggtctc taccccttgg caattccagt cacaatgacc ttatggtaca     4500

tgtggcaagt gaaaacacaa agatcaggag ccctgtggga cgtcccctca cccgctgcca     4560

ctaaaaaagc cgcactgtct gaaggagtgt acaggatcat gcaaagaggg ttattcggga     4620

aaactcaggt tggagtaggg atacacatgg aaggtgtatt tcacacaatg tggcatgtaa     4680

caagaggatc agtgatctgc cacgagactg ggagattgga gccatcttgg gctgacgtca     4740

ggaatgacat gatatcatac ggtgggggat ggaggcttgg agacaaatgg gacaaagaag     4800

aagacgttca ggtcctcgcc atagaaccag gaaaaaatcc taaacatgtc caaacgaaac     4860

ctggcctttt caagacccta actggagaaa ttggagcagt aacattagat ttcaaacccg     4920

gaacgtctgg ttctcccatc atcaacagga aaggaaaagt catcggactc tatggaaatg     4980

gagtagttac caaatcaggt gattacgtca gtgccataac gcaagccgaa agaattggag     5040

agccagatta tgaagtggat gaggacattt ttcgaaagaa aagattaact ataatggact     5100

tacaccccgg agctggaaag acaaaaagaa ttcttccatc aatagtgaga gaagccttaa     5160

aaaggaggct acgaactttg attttagctc ccacgagagt ggtggcggcc gagatggaag     5220

aggccctacg tggactgcca atccgttatc agaccccagc tgtgaaatca gaacacacag     5280

gaagagagat tgtagacctc atgtgtcatg caaccttcac aacaagactt ttgtcatcaa     5340

ccagggttcc aaattacaac cttatagtga tggatgaagc acatttcacc gatccttcta     5400

gtgtcgcggc tagaggatac atctcgacca gggtggaaat gggagaggca gcagccatct     5460

tcatgaccgc aacccctccc ggagcgacag atccctttcc ccagagcaac agcccaatag     5520

aagacatcga gagggaaatt ccggaaaggt catggaacac agggttcgac tggataacag     5580

actaccaagg gaaaactgtg tggtttgttc ccagcataaa agctggaaat gacattgcaa     5640

attgtttgag aaagtcggga aagaaagtta tccagttgag taggaaaacc tttgatacag     5700

agtatccaaa aacgaaactc acggactggg actttgtggt cactacagac atatctgaaa     5760

tgggggccaa ttttagagcc gggagagtga tagaccctag aagatgcctc aagccagtta     5820

tcctaacaga tgggccagag agagtcattt tagcaggtcc tattccagtg actccagcaa     5880

gcgctgctca gagaagaggg cgaataggaa ggaacccagc acaagaagac gaccaatacg     5940

ttttctccgg agacccacta aaaaatgatg aagatcatgc ccactggaca gaagcaaaga     6000

tgctgcttga caatatctac accccagaag ggatcattcc aacattgttt ggtccggaaa     6060

gggaaaaaac ccaagccatt gatggagagt ttcgcctcag aggggaacaa aggaagactt     6120

ttgtggaatt aatgaggaga ggagaccttc cggtgtggct gagctataag gtagcttctg     6180

ctggcatttc ttacaaagat cgggaatggt gcttcacagg ggaaagaaat aaccaaattt     6240

tagaagaaaa catggaggtt gaaatttgga ctagagaggg agaaaagaaa aagctaaggc     6300

caagatggtt agatgcacgt gtatacgctg accccatggc tttgaaggat ttcaaggagt     6360

ttgccagtgg aaggaagagt ataactctcg acatcctaac agagattgcc agtttgccaa     6420

cttacctttc ctctagggcc aagctcgccc ttgataacat agtcatgctc cacacaacag     6480

aaagaggagg gagggcctat caacacgccc tgaacgaact tccggagtca ctggaaacac     6540

tcatgcttgt agctttacta ggtgctatga cagcaggcat cttcctgttt ttcatgcaag     6600

ggaaaggaat agggaaattg tcaatgggtt tgataaccat tgcggtggct agtggcttgc     6660

tctgggtagc agaaattcaa ccccagtgga tagcggcctc aatcatacta gagttttttc     6720

tcatggtact gttgataccg gaaccagaaa aacaaaggac cccacaagac aatcaattga     6780

tctacgtcat attgaccatt ctcaccatca ttggtctaat agcagccaac gagatggggc     6840

tgattgaaaa aacaaaaacg gattttgggt tttaccaggt aaaaacagaa accaccatcc     6900

tcgatgtgga cttgagacca gcttcagcat ggacgctcta tgcagtagcc accacaattc     6960

tgactcccat gctgagacac accatagaaa acacgtcggc caacctatct ctagcagcca     7020

ttgccaacca ggcagccgtc ctaatggggc ttggaaaagg atggccgctc cacagaatgg     7080

acctcggtgt gccgctgtta gcaatgggat gctattctca agtgaaccca acaaccttga     7140

cagcatcctt agtcatgctt ttagtccatt atgcaataat aggcccagga ttgcaggcaa     7200

aagccacaag agaggcccag aaaaggacag ctgctgggat catgaaaaat cccacagtgg     7260

acgggataac agtaatagat ctagaaccaa tatcctatga cccaaaattt gaaaagcaat     7320

tagggcaggt catgctacta gtcttgtgtg ctggacaact actcttgatg agaacaacat     7380

gggctttctg tgaagtcttg actttggcca caggaccaat cttgaccttg tgggagggca     7440

acccgggaag gttttggaac acgaccatag ccgtatccac cgccaacatt ttcaggggaa     7500

gttacttggc gggagctgga ctggcttttt cactcataaa gaatgcacaa acccctagga     7560

ggggaactgg gaccacagga gagacactgg gagagaagtg gaagagacag ctaaactcat     7620

tagacagaag agagtttgaa gagtataaaa gaagtggaat actagaagtg gacaggactg     7680

aagccaagtc tgccctgaaa gatgggtcta aaatcaagca tgcagtatct agagggtcca     7740

gtaagatcag atggattgtt gagagaggga tggtaaagcc aaaagggaaa gttgtagatc     7800

ttggctgtgg gagaggagga tggtcttatt acatggcgac actcaagaac gtgactgaag     7860

tgaaagggta tacaaaagga ggtccaggac atgaagaacc gattcccatg gctacttatg     7920

gttggaattt ggtcaaactc cattcagggg ttgacgtgtt ctacaaaccc acagagcaag     7980

tggacaccct gctctgtgat attggggagt catcttctaa tccaacaata gaggaaggaa     8040

gaacattaag agttttgaag atggtggagc catggctctc ttcaaaacct gaattctgca     8100

tcaaagtcct taacccctac atgccaacag tcatagaaga gctggagaaa ctgcagagaa     8160

aacatggtgg gaaccttgtc agatgcccgc tgtccaggaa ctccacccat gagatgtatt     8220

gggtgtcagg agcgtcggga aacattgtga gctctgtgaa cacaacatca aagatgttgt     8280

tgaacaggtt cacaacaagg cataggaaac ccacttatga gaaggacgta gatcttgggg     8340

caggaacgag aagtgtctcc actgaaacag aaaaaccaga catgacaatc attgggagaa     8400

ggcttcagcg attgcaagaa gagcacaaag aaacctggca ttatgatcag gaaaacccat     8460

acagaacctg ggcgtatcat ggaagctatg aagctccttc gacaggctct gcatcctcca     8520

tggtgaacgg ggtagtaaaa ctgctaacaa aaccctggga tgtgattcca atggtgactc     8580

agttagccat gacagataca accccttttg ggcaacaaag agtgttcaaa gagaaggtgg     8640

ataccagaac accacaacca aaacccggta cacgaatggt tatgaccacg acagccaatt     8700

ggctgtgggc cctccttgga aagaagaaaa atcccagact gtgcacaagg gaagagttca     8760

tctcaaaagt tagatcaaac gcagccatag gcgcagtctt tcaggaagaa cagggatgga     8820

catcagccag tgaagctgtg aatgacagcc ggttttggga actggttgac aaagaaaggg     8880

ccctacacca ggaagggaaa tgtgaatcgt gtgtctataa catgatggga aaacgtgaga     8940

aaaagttagg agagtttggc agagccaagg gaagccgagc aatctggtac atgtggctgg     9000

gagcgcggtt tctggaattt gaagccctgg gttttttgaa tgaagatcac tggtttggca     9060

gagaaaattc atggagtgga gtggaagggg aaggtctgca cagattggga tatatcctgg     9120

aggagataga caagaaggat ggagacctaa tgtatgctga tgacacagca ggctgggaca     9180

caagaatcac tgaggatgac cttcaaaatg aggaactgat cacggaacag atggctcccc     9240

accacaagat cctagccaaa gccattttca aactaaccta tcaaaacaaa gtggtgaaag     9300

tcctcagacc cacaccgaga ggagcggtga tggatatcat atccaggaaa gaccaaagag     9360

gtagtggaca agttggaaca tatggtttga acacattcac caacatggaa gttcaactca     9420

tccgccaaat ggaagctgaa ggagtcatca cacaagatga catgcagaac ccaaaagggt     9480

tgaaagaaag agttgagaaa tggctgaaag agtgtggtgt cgacaggtta aagaggatgg     9540

caatcagtgg agacgattgc gtggtgaagc ccctagatga gaggtttggc acttccctcc     9600

tcttcttgaa cgacatggga aaggtgagga aagacattcc gcagtgggaa ccatctaagg     9660

gatggaaaaa ctggcaagag gttccttttt gctcccacca ctttcacaag atctttatga     9720

aggatggccg ctcactagtt gttccatgta gaaaccagga tgaactgata gggagagcca     9780

gaatctcgca gggagctgga tggagcttaa gagaaacagc ctgcctgggc aaagcttacg     9840

cccagatgtg gtcgcttatg tacttccaca gaagggatct gcgtttagcc tccatggcca     9900

tatgctcagc agttccaacg gaatggtttc caacaagcag aacaacatgg tcaatccacg     9960

ctcatcacca gtggatgacc actgaagata tgctcaaagt gtggaacaga gtgtggatag    10020

aagacaaccc taatatgact gacaagactc cagtccattc gtgggaagat ataccttacc    10080

tagggaaaag agaggatttg tggtgtggat ccctgattgg actttcttcc agagccacct    10140

gggcgaagaa cattcacacg gccataaccc aggtcaggaa cctgatcgga aaagaggaat    10200

acgtggatta catgccagta atgaaaagat acagtgctcc ttcagagagt gaaggagttc    10260

tgtaattacc aacaacaaac accaaaggct attgaagtca ggccacttgt gccacggttt    10320

gagcaaaccg tgctgcctgt agctccgcca ataatgggag gcgtaataat ccccagggag    10380

gccatgcgcc acggaagctg tacgcgtggc atattggact agcggttaga ggagacccct    10440

cccatcactg acaaaacgca gcaaaagggg gcccgaagcc aggaggaagc tgtactcctg    10500

gtggaaggac tagaggttag aggagacccc cccaacacaa aaacagcata ttgacgctgg    10560

gaaagaccag agatcctgct gtctctgcaa catcaatcca ggcacagagc gccgcaagat    10620

ggattggtgt tgttgatcca acaggttct                                      10649


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  2
aaaccgtgct gcctgtagct                                                   20


<210>  3
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  3
ggtctcctct aaccgctagt cca                                               23


<210>  4
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  4
cggaagctgt acgcgtg                                                      17


<210>  5
<211>  113
<212>  DNA
<213>  Dengue virus type 4 strain 814669

<400>  5
aaaccgtgct gcctgtagct ccgccaataa tgggaggcgt aataatcccc agggaggcca       60

tgcgccacgg aagctgtacg cgtggcatat tggactagcg gttagaggag acc             113


