
                                SEQUENCE LISTING

<110> The General Hospital Corporation

<120> Compounds for Improving mRNA Splicing
  

<130> 40978-0010WO1

<150> US 62/104,547       
<151> 2015-01-16  

<150> US 62/180,380       
<151> 2015-06-16  

<160> 14

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> EXON19 Forward primer

<400> 1
cctgagcagc aatcatgtg                                              19

<210> 2
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> EXON23 Reverse primer

<400> 2
tacatggtct tcgtgacatc                                             20

<210> 3
<211> 9801
<212> DNA
<213> Artificial Sequence

<220> 
<223> pcDNA3.1/V5HisTOPO with Renilla-Familial Dysautonomia-Firefly

<400> 3
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg 60
ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg 120
cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc 180
ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt 240
gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata 300
tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc 360
cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc 420
attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt 480
atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt 540
atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca 600
tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg 660
actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc 720
aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg 780
gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca 840
ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctggctagt 900
taagcttggt accgagctcg gatccggtac tgttggtaaa gccaccatgg cttccaaggt 960
gtacgacccc gagcaacgca aacgcatgat cactgggcct cagtggtggg ctcgctgcaa 1020
gcaaatgaac gtgctggact ccttcatcaa ctactatgat tccgagaagc acgccgagaa 1080
cgccgtgatt tttctgcatg gtaacgctgc ctccagctac ctgtggaggc acgtcgtgcc 1140
tcacatcgag cccgtggcta gatgcatcat ccctgatctg atcggaatgg gtaagtccgg 1200
caagagcggg aatggctcat atcgcctcct ggatcactac aagtacctca ccgcttggtt 1260
cgagctgctg aaccttccaa agaaaatcat ctttgtgggc cacgactggg gggcttgtct 1320
ggcctttcac tactcctacg agcaccaaga caagatcaag gccatcgtcc atgctgagag 1380
tgtcgtggac gtgatcgagt cctgggacga gtggcctgac atcgaggagg atatcgccct 1440
gatcaagagc gaagagggcg agaaaatggt gcttgagaat aacttcttcg tcgagaccat 1500
gctcccaagc aagatcatgc ggaaactgga gcctgaggag ttcgctgcct acctggagcc 1560
attcaaggag aagggcgagg ttagacggcc taccctctcc tggcctcgcg agatccctct 1620
cgttaaggga ggcaagcccg acgtcgtcca gattgtccgc aactacaacg cctaccttcg 1680
ggccagcgac gatctgccta agatgttcat cgagtccgac cctgggttct tttccaacgc 1740
tattgtcgag ggagctaaga agttccctaa caccgagttc gtgaaggtga agggcctcca 1800
cttcagccag gaggacgctc cagatgaaat gggtaagtac atcaagagct tcgtggagcg 1860
cgtgctgaag aacgagcagg gatccactag tccaatgtgg tggaattgcc cttcattaca 1920
ggccggcctg agcagcaatc atgtgtccca tggggaagtt ctgcggaaag tggagagggg 1980
ttcacggatt gtcactgttg tgccccagga cacaaagctt gtattacagg taagctggtt 2040
tttcagacaa gatagatagt ctgattgtca ttcagccaag taccaagcat aattcttgca 2100
ggttgtattt taggctttct tattctttgt atcgtttatt gtaaaccttt ccttgatagt 2160
tttctgttag ctttattcaa aggagtgttg atacaggctg tgaccataag gctcaaagcg 2220
aaacttttct tgaaagtcaa gataaatata gagaacaaca agattctgct aaaagtgtgc 2280
tgattttaga gagttgtggt aattctctgt gaagagttag gtaaaatggt gtatcctggc 2340
tatttaaatg ttttctactt aattaaaaat gttactgctt taatttattt aagatgccaa 2400
ggggaaactt agaagttgtt catcatcgag ccctggtttt agctcagatt cggaagtggt 2460
tggacaagta agcgccattg tactgtttgc gactagttag cttgtgattt atgtgtgaag 2520
acaataagta ttttattaca atttcgagaa cttaaaatta tgaaaagccc tcattaccta 2580
tatcatcaat cagattctta gaggctcttt tttttttttt taactttttt actttaatgc 2640
agtattttgt agtggagatt cctagcagaa agaatcgtga cactcatcat ataaaggagg 2700
gcttctctta acctgaggga acacatgtgg gttttaggtg gcctgtgaac ccagggagat 2760
tgtacacacc aaaccttgtc tttgtgtatt tattcaagta gaaagcccac agctttcaat 2820
agatttacag cggggcctat gacccagaaa agcctgagct actcttgtga aggaaatgac 2880
tgattttctg aacctatttg gaggaaactt tgtattggaa agatctatac taatgttttg 2940
tttaaaaagt agacctgaat tccatgatga ttttctttgt tttttttttg agacagagtc 3000
ttgctctgtc acccaggctg gagtacagtg gcgcaatctc ggcttactgc aacctctgcc 3060
ttctgggttc aagcaatcct cccacttcag cctcccgcat agctaggatt acaggtgtgc 3120
accacgcctg gctaattttt ttttttgtat tttcagtaga gacagggttt caccatgttg 3180
gccaggctgg tctcaaactc ctgacctcaa gtgttctgcc cacctcggcc tcccaaagtg 3240
ctaggattac aggtgtgaac caccgtgccc gggcttctgt aatgattttc tgttgtatgt 3300
atgtgaagat gtagttctca gacagtcatg atgactaaat tacacctttt aagaaggtaa 3360
atgaatgtgg tacctgattt ttttattctg taatttcaga gtagaaatcc agtgatagca 3420
gcttggcatt ggggctgtaa tctgattata actggtttgt atcataatga aaatatgctg 3480
ggcccatgga gctcagtttt tgtgaatatc ttttctattc tttctctgtc ttctcacaga 3540
cttatgttta aagaggcatt tgaatgcatg agaaagctga gaatcaatct caatctgatt 3600
tatgatcata accctaagct ggaagatgcc aaaaacatta agaagggccc agcgccattc 3660
tacccactcg aagacgggac cgccggcgag cagctgcaca aagccatgaa gcgctacgcc 3720
ctggtgcccg gcaccatcgc ctttaccgac gcacatatcg aggtggacat tacctacgcc 3780
gagtacttcg agatgagcgt tcggctggca gaagctatga agcgctatgg gctgaataca 3840
aaccatcgga tcgtggtgtg cagcgagaat agcttgcagt tcttcatgcc cgtgttgggt 3900
gccctgttca tcggtgtggc tgtggcccca gctaacgaca tctacaacga gcgcgagctg 3960
ctgaacagca tgggcatcag ccagcccacc gtcgtattcg tgagcaagaa agggctgcaa 4020
aagatcctca acgtgcaaaa gaagctaccg atcatacaaa agatcatcat catggatagc 4080
aagaccgact accagggctt ccaaagcatg tacaccttcg tgacttccca tttgccaccc 4140
ggcttcaacg agtacgactt cgtgcccgag agcttcgacc gggacaaaac catcgccctg 4200
atcatgaaca gtagtggcag taccggattg cccaagggcg tagccctacc gcaccgcacc 4260
gcttgtgtcc gattcagtca tgcccgcgac cccatcttcg gcaaccagat catccccgac 4320
accgctatcc tcagcgtggt gccatttcac cacggcttcg gcatgttcac cacgctgggc 4380
tacttgatct gcggctttcg ggtcgtgctc atgtaccgct tcgaggagga gctattcttg 4440
cgcagcttgc aagactataa gattcaatct gccctgctgg tgcccacact atttagcttc 4500
ttcgctaaga gcactctcat cgacaagtac gacctaagca acttgcacga gatcgccagc 4560
ggcggggcgc cgctcagcaa ggaggtaggt gaggccgtgg ccaaacgctt ccacctacca 4620
ggcatccgcc agggctacgg cctgacagaa acaaccagcg ccattctgat cacccccgaa 4680
ggggacgaca agcctggcgc agtaggcaag gtggtgccct tcttcgaggc taaggtggtg 4740
gacttggaca ccggtaagac actgggtgtg aaccagcgcg gcgagctgtg cgtccgtggc 4800
cccatgatca tgagcggcta cgttaacaac cccgaggcta caaacgctct catcgacaag 4860
gacggctggc tgcacagcgg cgacatcgcc tactgggacg aggacgagca cttcttcatc 4920
gtggaccggc tgaagagcct gatcaaatac aagggctacc aggtagcccc agccgaactg 4980
gagagcatcc tgctgcaaca ccccaacatc ttcgacgccg gggtcgccgg cctgcccgac 5040
gacgatgccg gcgagctgcc cgccgcagtc gtcgtgctgg aacacggtaa aaccatgacc 5100
gagaaggaga tcgtggacta tgtggccagc caggttacaa ccgccaagaa gctgcgcggt 5160
ggtgttgtgt tcgtggacga ggtgcctaaa ggactgaccg gcaagttgga cgcccgcaag 5220
atccgcgaga ttctcattaa ggccaagaag ggcggcaaga tcgccgtgta ataattctag 5280
agggcccgcg gttcgaaggt aagcctatcc ctaaccctct cctcggtctc gattctacgc 5340
gtaccggtca tcatcaccat caccattgag tttaaacccg ctgatcagcc tcgactgtgc 5400
cttctagttg ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag 5460
gtgccactcc cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta 5520
ggtgtcattc tattctgggg ggtggggtgg ggcaggacag caagggggag gattgggaag 5580
acaatagcag gcatgctggg gatgcggtgg gctctatggc ttctgaggcg gaaagaacca 5640
gctggggctc tagggggtat ccccacgcgc cctgtagcgg cgcattaagc gcggcgggtg 5700
tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 5760
ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 5820
gcatcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 5880
agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 5940
tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 6000
tctcggtcta ttcttttgat ttataaggga ttttggggat ttcggcctat tggttaaaaa 6060
atgagctgat ttaacaaaaa tttaacgcga attaattctg tggaatgtgt gtcagttagg 6120
gtgtggaaag tccccaggct ccccaggcag gcagaagtat gcaaagcatg catctcaatt 6180
agtcagcaac caggtgtgga aagtccccag gctccccagc aggcagaagt atgcaaagca 6240
tgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc ccgcccctaa 6300
ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt atttatgcag 6360
aggccgaggc cgcctctgcc tctgagctat tccagaagta gtgaggaggc ttttttggag 6420
gcctaggctt ttgcaaaaag ctcccgggag cttgtatatc cattttcgga tctgatcaag 6480
agacaggatg aggatcgttt cgcatgattg aacaagatgg attgcacgca ggttctccgg 6540
ccgcttgggt ggagaggcta ttcggctatg actgggcaca acagacaatc ggctgctctg 6600
atgccgccgt gttccggctg tcagcgcagg ggcgcccggt tctttttgtc aagaccgacc 6660
tgtccggtgc cctgaatgaa ctgcaggacg aggcagcgcg gctatcgtgg ctggccacga 6720
cgggcgttcc ttgcgcagct gtgctcgacg ttgtcactga agcgggaagg gactggctgc 6780
tattgggcga agtgccgggg caggatctcc tgtcatctca ccttgctcct gccgagaaag 6840
tatccatcat ggctgatgca atgcggcggc tgcatacgct tgatccggct acctgcccat 6900
tcgaccacca agcgaaacat cgcatcgagc gagcacgtac tcggatggaa gccggtcttg 6960
tcgatcagga tgatctggac gaagagcatc aggggctcgc gccagccgaa ctgttcgcca 7020
ggctcaaggc gcgcatgccc gacggcgagg atctcgtcgt gacccatggc gatgcctgct 7080
tgccgaatat catggtggaa aatggccgct tttctggatt catcgactgt ggccggctgg 7140
gtgtggcgga ccgctatcag gacatagcgt tggctacccg tgatattgct gaagagcttg 7200
gcggcgaatg ggctgaccgc ttcctcgtgc tttacggtat cgccgctccc gattcgcagc 7260
gcatcgcctt ctatcgcctt cttgacgagt tcttctgagc gggactctgg ggttcgcgaa 7320
atgaccgacc aagcgacgcc caacctgcca tcacgagatt tcgattccac cgccgccttc 7380
tatgaaaggt tgggcttcgg aatcgttttc cgggacgccg gctggatgat cctccagcgc 7440
ggggatctca tgctggagtt cttcgcccac cccaacttgt ttattgcagc ttataatggt 7500
tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct 7560
agttgtggtt tgtccaaact catcaatgta tcttatcatg tctgtatacc gtcgacctct 7620
agctagagct tggcgtaatc atggtcatag ctgtttcctg tgtgaaattg ttatccgctc 7680
acaattccac acaacatacg agccggaagc ataaagtgta aagcctgggg tgcctaatga 7740
gtgagctaac tcacattaat tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg 7800
tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga gaggcggttt gcgtattggg 7860
cgctcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg 7920
gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga taacgcagga 7980
aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg 8040
gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag 8100
aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc 8160
gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg 8220
ggaagcgtgg cgctttctca atgctcacgc tgtaggtatc tcagttcggt gtaggtcgtt 8280
cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc 8340
ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc 8400
actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg 8460
tggcctaact acggctacac tagaaggaca gtatttggta tctgcgctct gctgaagcca 8520
gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc 8580
ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat 8640
cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt 8700
ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt 8760
tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca atgcttaatc 8820
agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc ctgactcccc 8880
gtcgtgtaga taactacgat acgggagggc ttaccatctg gccccagtgc tgcaatgata 8940
ccgcgagacc cacgctcacc ggctccagat ttatcagcaa taaaccagcc agccggaagg 9000
gccgagcgca gaagtggtcc tgcaacttta tccgcctcca tccagtctat taattgttgc 9060
cgggaagcta gagtaagtag ttcgccagtt aatagtttgc gcaacgttgt tgccattgct 9120
acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt cattcagctc cggttcccaa 9180
cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa aagcggttag ctccttcggt 9240
cctccgatcg ttgtcagaag taagttggcc gcagtgttat cactcatggt tatggcagca 9300
ctgcataatt ctcttactgt catgccatcc gtaagatgct tttctgtgac tggtgagtac 9360
tcaaccaagt cattctgaga atagtgtatg cggcgaccga gttgctcttg cccggcgtca 9420
atacgggata ataccgcgcc acatagcaga actttaaaag tgctcatcat tggaaaacgt 9480
tcttcggggc gaaaactctc aaggatctta ccgctgttga gatccagttc gatgtaaccc 9540
actcgtgcac ccaactgatc ttcagcatct tttactttca ccagcgtttc tgggtgagca 9600
aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg cgacacggaa atgttgaata 9660
ctcatactct tcctttttca atattattga agcatttatc agggttattg tctcatgagc 9720
ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg cacatttccc 9780
cgaaaagtgc cacctgacgt c                                           9801

<210> 4
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> T7 promoter/priming site

<400> 4
taatacgact cactataggg                                             20

<210> 5
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer (Luciferase) 146Rev

<400> 5
ctcggcgtag gtaatgtcc                                              19

<210> 6
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer (Luciferase) 146Rev On Sequence

<400> 6
ggacattacc tacgccgag                                              19

<210> 7
<211> 116
<212> DNA
<213> Homo sapiens

<220> 
<223> Exon 19

<400> 7
cattacaggc cggcctgagc agcaatcatg tgtcccatgg ggaagttctg cggaaagtgg 60
agaggggttc acggattgtc actgttgtgc cccaggacac aaagcttgta ttacag     116

<210> 8
<211> 363
<212> DNA
<213> Homo sapiens

<220> 
<223> Intron between Exon 19 and Exon 20

<400> 8
taagctggtt tttcagacaa gatagatagt ctgattgtca ttcagccaag taccaagcat 60
aattcttgca ggttgtattt taggctttct tattctttgt atcgtttatt gtaaaccttt 120
ccttgatagt tttctgttag ctttattcaa aggagtgttg atacaggctg tgaccataag 180
gctcaaagcg aaacttttct tgaaagtcaa gataaatata gagaacaaca agattctgct 240
aaaagtgtgc tgattttaga gagttgtggt aattctctgt gaagagttag gtaaaatggt 300
gtatcctggc tatttaaatg ttttctactt aattaaaaat gttactgctt taatttattt 360
aag                                                               363

<210> 9
<211> 74
<212> DNA
<213> Homo sapiens


<220> 
<223> Exon 20

<400> 9
atgccaaggg gaaacttaga agttgttcat catcgagccc tggttttagc tcagattcgg 60
aagtggttgg acaa                                                   74

<210> 10
<211> 1072
<212> DNA
<213> Homo sapiens

<220> 
<223> Intron between Exon 20 and Exon 21

<400> 10
gtaagcgcca ttgtactgtt tgcgactagt tagcttgtga tttatgtgtg aagacaataa 60
gtattttatt acaatttcga gaacttaaaa ttatgaaaag ccctcattac ctatatcatc 120
aatcagattc ttagaggctc tttttttttt ttttaacttt tttactttaa tgcagtattt 180
tgtagtggag attcctagca gaaagaatcg tgacactcat catataaagg agggcttctc 240
ttaacctgag ggaacacatg tgggttttag gtggcctgtg aacccaggga gattgtacac 300
accaaacctt gtctttgtgt atttattcaa gtagaaagcc cacagctttc aatagattta 360
cagcggggcc tatgacccag aaaagcctga gctactcttg tgaaggaaat gactgatttt 420
ctgaacctat ttggaggaaa ctttgtattg gaaagatcta tactaatgtt ttgtttaaaa 480
agtagacctg aattccatga tgattttctt tgtttttttt ttgagacaga gtcttgctct 540
gtcacccagg ctggagtaca gtggcgcaat ctcggcttac tgcaacctct gccttctggg 600
ttcaagcaat cctcccactt cagcctcccg catagctagg attacaggtg tgcaccacgc 660
ctggctaatt tttttttttg tattttcagt agagacaggg tttcaccatg ttggccaggc 720
tggtctcaaa ctcctgacct caagtgttct gcccacctcg gcctcccaaa gtgctaggat 780
tacaggtgtg aaccaccgtg cccgggcttc tgtaatgatt ttctgttgta tgtatgtgaa 840
gatgtagttc tcagacagtc atgatgacta aattacacct tttaagaagg taaatgaatg 900
tggtacctga tttttttatt ctgtaatttc agagtagaaa tccagtgata gcagcttggc 960
attggggctg taatctgatt ataactggtt tgtatcataa tgaaaatatg ctgggcccat 1020
ggagctcagt ttttgtgaat atcttttcta ttctttctct gtcttctcac ag         1072

<210> 11
<211> 79
<212> DNA
<213> Homo sapiens

<220> 
<223> Exon 21

<400> 11
acttatgttt aaagaggcat ttgaatgcat gagaaagctg agaatcaatc tcaatctgat 60
ttatgatcat aaccctaag                                              79

<210> 12
<211> 269
<212> DNA
<213> Homo sapiens

<220> 
<223> Exons 19-20-21

<400> 12
cattacaggc cggcctgagc agcaatcatg tgtcccatgg ggaagttctg cggaaagtgg 60
agaggggttc acggattgtc actgttgtgc cccaggacac aaagcttgta ttacagatgc 120
caaggggaaa cttagaagtt gttcatcatc gagccctggt tttagctcag attcggaagt 180
ggttggacaa acttatgttt aaagaggcat ttgaatgcat gagaaagctg agaatcaatc 240
tcaatctgat ttatgatcat aaccctaag                                   269

<210> 13
<211> 939
<212> DNA
<213> Renilla reniformis

<220> 
<223> RENILLA LUCIFERASE

<400> 13
atggcttcca aggtgtacga ccccgagcaa cgcaaacgca tgatcactgg gcctcagtgg 60
tgggctcgct gcaagcaaat gaacgtgctg gactccttca tcaactacta tgattccgag 120
aagcacgccg agaacgccgt gatttttctg catggtaacg ctgcctccag ctacctgtgg 180
aggcacgtcg tgcctcacat cgagcccgtg gctagatgca tcatccctga tctgatcgga 240
atgggtaagt ccggcaagag cgggaatggc tcatatcgcc tcctggatca ctacaagtac 300
ctcaccgctt ggttcgagct gctgaacctt ccaaagaaaa tcatctttgt gggccacgac 360
tggggggctt gtctggcctt tcactactcc tacgagcacc aagacaagat caaggccatc 420
gtccatgctg agagtgtcgt ggacgtgatc gagtcctggg acgagtggcc tgacatcgag 480
gaggatatcg ccctgatcaa gagcgaagag ggcgagaaaa tggtgcttga gaataacttc 540
ttcgtcgaga ccatgctccc aagcaagatc atgcggaaac tggagcctga ggagttcgct 600
gcctacctgg agccattcaa ggagaagggc gaggttagac ggcctaccct ctcctggcct 660
cgcgagatcc ctctcgttaa gggaggcaag cccgacgtcg tccagattgt ccgcaactac 720
aacgcctacc ttcgggccag cgacgatctg cctaagatgt tcatcgagtc cgaccctggg 780
ttcttttcca acgctattgt cgagggagct aagaagttcc ctaacaccga gttcgtgaag 840
gtgaagggcc tccacttcag ccaggaggac gctccagatg aaatgggtaa gtacatcaag 900
agcttcgtgg agcgcgtgct gaagaacgag cagggatcc                        939

<210> 14
<211> 1653
<212> DNA
<213> Artificial Sequence

<220> 
<223> FIREFLY LUCIFERASE (with Mutation ATG-CTG base 3619)

<400> 14
ctggaagatg ccaaaaacat taagaagggc ccagcgccat tctacccact cgaagacggg 60
accgccggcg agcagctgca caaagccatg aagcgctacg ccctggtgcc cggcaccatc 120
gcctttaccg acgcacatat cgaggtggac attacctacg ccgagtactt cgagatgagc 180
gttcggctgg cagaagctat gaagcgctat gggctgaata caaaccatcg gatcgtggtg 240
tgcagcgaga atagcttgca gttcttcatg cccgtgttgg gtgccctgtt catcggtgtg 300
gctgtggccc cagctaacga catctacaac gagcgcgagc tgctgaacag catgggcatc 360
agccagccca ccgtcgtatt cgtgagcaag aaagggctgc aaaagatcct caacgtgcaa 420
aagaagctac cgatcataca aaagatcatc atcatggata gcaagaccga ctaccagggc 480
ttccaaagca tgtacacctt cgtgacttcc catttgccac ccggcttcaa cgagtacgac 540
ttcgtgcccg agagcttcga ccgggacaaa accatcgccc tgatcatgaa cagtagtggc 600
agtaccggat tgcccaaggg cgtagcccta ccgcaccgca ccgcttgtgt ccgattcagt 660
catgcccgcg accccatctt cggcaaccag atcatccccg acaccgctat cctcagcgtg 720
gtgccatttc accacggctt cggcatgttc accacgctgg gctacttgat ctgcggcttt 780
cgggtcgtgc tcatgtaccg cttcgaggag gagctattct tgcgcagctt gcaagactat 840
aagattcaat ctgccctgct ggtgcccaca ctatttagct tcttcgctaa gagcactctc 900
atcgacaagt acgacctaag caacttgcac gagatcgcca gcggcggggc gccgctcagc 960
aaggaggtag gtgaggccgt ggccaaacgc ttccacctac caggcatccg ccagggctac 1020
ggcctgacag aaacaaccag cgccattctg atcacccccg aaggggacga caagcctggc 1080
gcagtaggca aggtggtgcc cttcttcgag gctaaggtgg tggacttgga caccggtaag 1140
acactgggtg tgaaccagcg cggcgagctg tgcgtccgtg gccccatgat catgagcggc 1200
tacgttaaca accccgaggc tacaaacgct ctcatcgaca aggacggctg gctgcacagc 1260
ggcgacatcg cctactggga cgaggacgag cacttcttca tcgtggaccg gctgaagagc 1320
ctgatcaaat acaagggcta ccaggtagcc ccagccgaac tggagagcat cctgctgcaa 1380
caccccaaca tcttcgacgc cggggtcgcc ggcctgcccg acgacgatgc cggcgagctg 1440
cccgccgcag tcgtcgtgct ggaacacggt aaaaccatga ccgagaagga gatcgtggac 1500
tatgtggcca gccaggttac aaccgccaag aagctgcgcg gtggtgttgt gttcgtggac 1560
gaggtgccta aaggactgac cggcaagttg gacgcccgca agatccgcga gattctcatt 1620
aaggccaaga agggcggcaa gatcgccgtg taa                              1653
