                         SEQUENCE LISTING

<110>  Johns Hopkins Technology Ventures
        
<120>  PHARMACOLOGICAL MODULATORS OF GABAA RECEPTORS AND THEIR USE

<130>  P13167-02

<150>  62/103,669
<151>  2015-01-15

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  64
<212>  PRT
<213>  Micrurus mipartitus

<400>  1

Leu Thr Cys Lys Thr Cys Pro Phe Thr Thr Cys Pro Asn Ser Glu Ser 
1               5                   10                  15      


Cys Pro Gly Gly Gln Ser Ile Cys Tyr Gln Arg Lys Trp Glu Glu His 
            20                  25                  30          


Arg Gly Glu Arg Ile Glu Arg Arg Cys Val Ala Asn Cys Pro Ala Phe 
        35                  40                  45              


Gly Ser His Asp Thr Ser Leu Leu Cys Cys Thr Arg Asp Asn Cys Asn 
    50                  55                  60                  


<210>  2
<211>  64
<212>  PRT
<213>  Micrurus mipartitus

<400>  2

Leu Thr Cys Lys Thr Cys Pro Phe Thr Thr Cys Pro Asn Ser Glu Ser 
1               5                   10                  15      


Cys Pro Gly Gly Gln Ser Ile Cys Tyr Gln Arg Lys Trp Glu Glu His 
            20                  25                  30          


His Gly Glu Arg Ile Glu Arg Arg Cys Val Ala Asn Cys Pro Ala Phe 
        35                  40                  45              


Gly Ser His Asp Thr Ser Leu Leu Cys Cys Thr Arg Asp Asn Cys Asn 
    50                  55                  60                  


<210>  3
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  3

Cys Lys Thr Cys Pro Phe Thr Thr Cys Pro Asn Ser Glu Ser Cys 
1               5                   10                  15  


<210>  4
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  4

Cys Tyr Gln Arg Lys Trp Glu Glu His Arg Gly Glu Arg Ile Glu Arg 
1               5                   10                  15      


Arg Cys 
        


<210>  5
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  5

Cys Tyr Gln Arg Lys Trp Glu Glu Arg Arg Gly Glu Arg Ile Glu Arg 
1               5                   10                  15      


Arg Cys 
        


<210>  6
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<223>  X can be any natural or unnatural amino acid

<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  X can be any natural or unnatural amino acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(23)
<223>  X can be any natural or unnatural amino acid

<220>
<221>  MISC_FEATURE
<222>  (42)..(44)
<223>  X can be any natural or unnatural amino acid

<220>
<221>  MISC_FEATURE
<222>  (55)..(56)
<223>  X can be any natural or unnatural amino acid

<400>  6

Xaa Xaa Cys Lys Thr Cys Pro Phe Thr Thr Cys Pro Asn Ser Glu Ser 
1               5                   10                  15      


Cys Xaa Xaa Xaa Xaa Xaa Xaa Cys Tyr Gln Arg Lys Trp Glu Glu His 
            20                  25                  30          


Arg Gly Glu Arg Ile Glu Arg Arg Cys Xaa Xaa Xaa Cys Pro Ala Phe 
        35                  40                  45              


Gly Ser His Asp Thr Ser Xaa Xaa Cys Cys Thr Arg Asp Asn Cys Asn 
    50                  55                  60                  


<210>  7
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  X can be any natural or nonnatural amino acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(23)
<223>  X can be any natural or nonnatural amino acid

<220>
<221>  MISC_FEATURE
<222>  (42)..(44)
<223>  X can be any natural or nonnatural amino acid

<220>
<221>  MISC_FEATURE
<222>  (55)..(56)
<223>  X can be any natural or nonnatural amino acid

<400>  7

Xaa Xaa Cys Lys Thr Cys Pro Phe Thr Thr Cys Pro Asn Ser Glu Ser 
1               5                   10                  15      


Cys Xaa Xaa Xaa Xaa Xaa Xaa Cys Tyr Gln Arg Lys Trp Glu Glu His 
            20                  25                  30          


His Gly Glu Arg Ile Glu Arg Arg Cys Xaa Xaa Xaa Cys Pro Ala Phe 
        35                  40                  45              


Gly Ser His Asp Thr Ser Xaa Xaa Cys Cys Thr Arg Asp Asn Cys Asn 
    50                  55                  60                  


<210>  8
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  8

Leu Thr Cys Lys Thr Cys Pro Phe Thr Thr Cys Pro Asn Ser Glu Ser 
1               5                   10                  15      


Cys Pro Gly Gly Gln Ser Ile Cys Tyr Gln Arg Lys Trp Glu Glu His 
            20                  25                  30          


Arg Gly Glu Arg Ile Glu Arg Arg Cys Val Ala Asn Cys Pro Ala Phe 
        35                  40                  45              


Gly Ser His Asp Thr Leu Leu Cys Cys Thr Arg Asp Asn Cys Asn 
    50                  55                  60              


<210>  9
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  9

Met Lys Cys Leu Ile Cys Pro Phe Thr Thr Cys Ser Gln Ser Glu Ser 
1               5                   10                  15      


Cys Pro Gly Gly Gln Ser Ile Cys Phe Gln Arg Lys Phe Asp Asp Arg 
            20                  25                  30          


His Gly Asp Arg Ile Glu Arg Gly Cys Ala Val Thr Cys Pro Pro Phe 
        35                  40                  45              


Gly Ser His Asp Thr Ile Phe Cys Cys Ser Thr Asn Asp Cys Asn 
    50                  55                  60              


<210>  10
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  10

Ile Glu Cys His Asn Cys Pro Phe Thr Thr Cys Gly Asn Ser Glu Ser 
1               5                   10                  15      


Cys Pro Gly Gly Gln Ser Ile Cys Val Gln Arg Lys Leu Glu Glu Lys 
            20                  25                  30          


Lys Gly Glu Arg Ile Glu Arg Ser Cys Thr Asp Gly Cys Pro Gly Phe 
        35                  40                  45              


Gly Ser His Asp Thr Val Glu Cys Cys Arg Ile Ala Arg Cys Asn 
    50                  55                  60              


<210>  11
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  11

Arg Gln Cys Tyr Thr Cys Pro Phe Thr Thr Cys His Asn Ser Glu Ser 
1               5                   10                  15      


Cys Pro Gly Gly Gln Ser Ile Cys Tyr Gln Arg Lys Tyr Glu Glu His 
            20                  25                  30          


Arg Gly Glu Arg Ile Glu Arg Lys Cys Ser Leu Ser Cys Pro Ser Phe 
        35                  40                  45              


Gly Ser His Asp Thr Leu Leu Cys Cys Ala Arg Pro Lys Cys Asn 
    50                  55                  60              


<210>  12
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  12

Phe Arg Cys Phe Arg Cys Pro Phe Thr Thr Cys Asn Asn Ser Glu Ser 
1               5                   10                  15      


Cys Pro Gly Gly Gln Ser Ile Cys Tyr Gln Arg Lys Trp Glu Glu His 
            20                  25                  30          


Arg Gly Glu Arg Ile Glu Arg Arg Cys Val Ala Asn Cys Pro Ala Phe 
        35                  40                  45              


Gly Ser His Asp Thr Leu Leu Cys Cys Lys Arg Glu Glu Cys Asn 
    50                  55                  60              


<210>  13
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  13

Leu Ser Cys Asn Thr Cys Pro Phe Thr Thr Cys Gln Asn Ser Glu Ser 
1               5                   10                  15      


Cys Pro Gly Gly Gln Ser Ile Cys Tyr Gln Arg Lys Trp Glu Glu His 
            20                  25                  30          


Arg Gly Glu Arg Ile Glu Arg Arg Cys Val Ala Asn Cys Pro Ala Phe 
        35                  40                  45              


Gly Ser His Asp Thr Leu Leu Cys Cys Thr Arg Asp Asn Cys Asn 
    50                  55                  60              


<210>  14
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  14

Leu Leu Cys Lys Thr Cys Pro Phe Thr Thr Cys Pro Asn Ser Glu Ser 
1               5                   10                  15      


Cys Pro Gly Gly Gln Ser Ile Cys Tyr Gln Arg Lys Trp Glu Glu His 
            20                  25                  30          


Arg Gly Glu Arg Ile Glu Arg Arg Cys Val Ala Asn Cys Pro Ala Phe 
        35                  40                  45              


Gly Ser His Asp Thr Leu Leu Cys Cys Thr Arg Asp Asn Cys Asn 
    50                  55                  60              


<210>  15
<211>  47
<212>  PRT
<213>  Rattus norvegicus

<400>  15

Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Thr Val Asp 
1               5                   10                  15      


Ser Gly Ile Val Gln Ser Ser Thr Gly Glu Tyr Val Val Met Thr Thr 
            20                  25                  30          


His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln Thr 
        35                  40                  45          


<210>  16
<211>  47
<212>  PRT
<213>  Rattus norvegicus

<400>  16

Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Ser Ile Gly 
1               5                   10                  15      


Lys Glu Thr Ile Lys Ser Ser Thr Gly Glu Tyr Thr Val Met Thr Ala 
            20                  25                  30          


His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln Thr 
        35                  40                  45          


<210>  17
<211>  47
<212>  PRT
<213>  Rattus norvegicus

<400>  17

Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly His Val Val Gly 
1               5                   10                  15      


Thr Glu Ile Ile Arg Ser Ser Thr Gly Glu Tyr Val Val Met Thr Thr 
            20                  25                  30          


His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln Thr 
        35                  40                  45          


<210>  18
<211>  47
<212>  PRT
<213>  Rattus norvegicus

<400>  18

Glu Ser Ser Ser Leu Val Gln Tyr Asp Leu Ile Gly Gln Thr Val Ser 
1               5                   10                  15      


Ser Glu Thr Ile Lys Ser Ile Thr Gly Glu Tyr Ile Val Met Thr Val 
            20                  25                  30          


Tyr Phe His Leu Arg Arg Lys Met Gly Tyr Phe Met Ile Gln Thr 
        35                  40                  45          


<210>  19
<211>  47
<212>  PRT
<213>  Rattus norvegicus

<400>  19

Asp Gly Ser Arg Leu Asn Gln Tyr His Leu Met Gly Gln Thr Val Gly 
1               5                   10                  15      


Thr Glu Asn Ile Ser Thr Ser Thr Gly Glu Tyr Thr Ile Met Thr Ala 
            20                  25                  30          


His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln Thr 
        35                  40                  45          


<210>  20
<211>  47
<212>  PRT
<213>  Rattus norvegicus

<400>  20

Glu Ser Ser Ser Leu Leu Gln Tyr Asp Leu Ile Gly Gln Thr Val Ser 
1               5                   10                  15      


Ser Glu Thr Ile Lys Ser Asn Thr Gly Glu Tyr Val Ile Met Thr Val 
            20                  25                  30          


Tyr Phe His Leu Gln Arg Lys Met Gly Tyr Phe Met Ile Gln Ile 
        35                  40                  45          


<210>  21
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  21

Leu Thr Cys His Thr Cys Pro Phe Thr Thr Cys Pro Asn Ser Glu Ser 
1               5                   10                  15      


Cys Pro Gly Gly Gln Ser Ile Cys Tyr Gln Arg Arg Trp Glu Glu His 
            20                  25                  30          


Arg Gly Glu Arg Ile Glu Arg Arg Cys Val Ala Asn Cys Pro Lys Phe 
        35                  40                  45              


Gly Ser His Asp Thr Ser Leu Leu Cys Cys Thr Arg Asp Asn Cys Asn 
    50                  55                  60                  


