                         SEQUENCE LISTING

<110>  ISIS INNOVATION LIMITED
 
<120>  TREATMENT

<130>  N404290WO

<150>  1500427.8
<151>  2015-01-12

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  1
uugaaaggcu auuucuuggu c                                                 21


<210>  2
<211>  21
<212>  RNA
<213>  Mus musculus

<400>  2
uugaaaggcu guuucuuggu c                                                 21


<210>  3
<211>  7
<212>  RNA
<213>  Homo sapiens

<400>  3
ccuuuca                                                                  7


<210>  4
<211>  3246
<212>  DNA
<213>  Homo sapiens

<400>  4
gggctcgggg gcggggaggc ccctccggcg gggcggccct gggtggtccg gcagaggcgg       60

aggccgctcc gagcctgtga gccctgggcg cctgcggagg cggggagagg gcggggtgtg      120

ccgccctggt ggggaccgcg gggtcggaga ggggacattg ccccccccga ggcgaacgtc      180

caaccgcggg tccgggtccc cgcccaaggc cgccccgcga ggtggcctcg gcccggccgt      240

ccccgagggt ggctcggatc ctttcaacca gcgcgctgga ggcgaagggg ctgcgccatt      300

ccgggtcagg cagccaacgc gggacacgcg cgtctccgag cttgcggccc gcgaaacccg      360

ggtgacctac cgcgccggtg ccctcaaagc ccccacgccc gggccggtgg ccgctgcagc      420

cactgagcca cgcggtctcc ccggcccggt cggcagaagg agctggtccg ttactagaaa      480

agtccagatg caaagtcggg ggtcgtgctg ccgcttcctg ccagcgcacc gcacccacct      540

ggggccgcca ccgaccgcac aggacgcgcc tcctaccccc tgttctggcc cggccgagag      600

ctggtgcccc cagcggccgc ccgcccccgt ccgcagaccc cggggccctt gctgctttgc      660

attgggaaca accggagcca ggcccggagc tgagggggcc agggcctttg gaggaagcat      720

tggcctccag gctgaagagc aagggccgtg tcacctgccc ggagggcggt ctcatctctg      780

cagccaggtc agaggaagca gcggtgggga gacggagtgc gcgagttggg aggctccacg      840

catcgtaggt ggagagctgg ctgccagcct ggcctgccct ctcttccccg tcccaccatc      900

tcgcttggct ccggcacctg cctgggaaga cccacacctc cgtctgcagt gcctcttccc      960

cctggaggcc ctgccctccg ctcggggtcc ccgcatcctt ccgtggccct cagagcatcg     1020

cctggggcgc ccgcggaact catctgttag gcctgggatg caggcaggca gaagtggggg     1080

tttaagtgga agcagtgagg gtgggggtcc ggtccaaact gtgccacctt ccaccccctg     1140

cccctgggag agcagacatc gcccactcgg gctcacagtg ccatccgggt gaggacctcc     1200

gtggagagct ctctttgcca aagaaaagca gttgcattag gtctgcgagc aggcagggtg     1260

gcctcttcct ggctccccat ccaccaagga agcttcaagt ccctgggaca caggtgggga     1320

actccagcac ccctggagga agggagactg aggttgggga gtggcatcca ggccctgact     1380

ctggggcacg gtggtctgtg caactgagac cctgcctcag gctccaacag cgcctgctcc     1440

tttccccagg ttgcagtgat caccagggga ggtgctgggc gtgcaggctg ccacaggagg     1500

ggtggggagg tggggagtct ctgtggcggg gtggtggggg cctaggccag tcagctgagg     1560

acgtgttggt gcactcccgg gagggcggta tgtgggtgag gatccccatg cagagtggtg     1620

cccacaaacc ccccttccag agtcatctct ggtccacctt gaagtcccca ggaaaatgac     1680

ctcgtcctcc gcgggtgtga gccactaggc ctgagaggac gccgggacgg agctttcaga     1740

gagggaggtg tcgggatggc ttgagggtca ccaggtatta attaagcact tgctgtgtgc     1800

caggcacttt cccacacagg atggagccgg gccaccctca cagctcctgc cctgcagacg     1860

ctggccttgt ggagggaggc aggcagcagg agcagtgctt tctgggcctc tgtagccaga     1920

gctggccctg ctgcagctta cgtctgcctg cagcccagac gtcctcctgg tcctcctgat     1980

gcccccgacc tccacggagg acgagcattt ccagcccagc cctccccatc ttcacctcgc     2040

actcccctga cacactggga gcctcctgat ccgtgaaccc gcgctggcgg gagtagctac     2100

tgaccgctgg ggacccctgc ccaggctgtt cgcatgtgga aaggattcag ggagcaggcg     2160

atgcccaaag cgtggagacc agcactgctc tctccccagt gacaggtgca cgcccagatc     2220

acggatgtgt cgggaacagc tgtgctcctg ctgctcagcg tccgtcactc caggctggga     2280

gcgggtcccc aagcttctgg ctgggcctat ccgtctccac tctcagtgtg ggggtggggg     2340

gcgccaacag cacgcatttg ctctctgcac ttctcgtctg ataatgggca gagggtcctt     2400

ctgcagcccc aaaacatccc tgggcaggag ccctggggcc ccaagcagcc agggaggtga     2460

gcaccaagga cctcccagag agcgtcacct tccgtcgagg gaggcccagc ctgggggcgg     2520

tgtctgagac ttggaatcaa cgcttccgtt ggtggcagta aatcctgtcc ctaaccctgc     2580

agtacagctg tgccgtgtac aggagggtgc tgtctgacgc cagacacctg gactacagat     2640

cgcagcctga ttcctggtca ttgctccact gaaccccaga ccccagcctc gttctgggcc     2700

ctcatcccct agatccaggg accccagccc catttcagcc cttgggccct tgtaggatgc     2760

gaggccctgg gccccagccc ccagcccatc cgtggcccag gcactggggg gctgaggtcc     2820

tctgagaagg gacacagggc ctggggggct ctctcagccc atcagcagga gaggactgac     2880

tccagaaaaa tcagcgtttg tacccactca ggctgccaag acctgtgtcc gtccttccaa     2940

gctcaacctt cagagttcat gaggcccctt gcccagaatg tccacagagt tcatgaggcc     3000

ccttgcccgg aatgtccaca tttgaaacct cccaacaccg agccccattt caagtataac     3060

caggagggaa aatggtgctt gaaataagca tgccacaaag gaaaacctgc tttctcgaaa     3120

tgggccctgg ccgcccaggc cctgacctcc ccggccagga tggaacgttc cagagaccca     3180

ttagtgccaa aggcaaatga aaacacaccc tgtgaaaatg tcaaaaaata aaaaaaaaaa     3240

aaaaaa                                                                3246


<210>  5
<211>  1234
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (523)..(523)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (676)..(676)
<223>  n is a, c, g, or t

<400>  5
gatctcagca gcacggcttg actttcgggc ggcaggcaag gatgctaatc cacaaggttc       60

ctgagtccaa catccctccc tccaatgtgg ggctcgaatc cgctattgca accaaacccg      120

ggttctgccc gcagggtggc gcaatgacaa gagccaccag gtgaccctgg taactcccgc      180

acctagacct acaggagcag tttttctgca gcaccacatc tgtagccctg catgccgctg      240

gctccagtgt tgtgtgtgtg gtcatgctcc atccagccca gcagcaactt tggtgtttga      300

cacccctcgg gaggcaccgc tttggaagag actggtaaca gcagggtggg accggctact      360

tagctgttct cagtctgaaa ggattctgga aaggggctct atttaaccca agcactggag      420

tccaacacag cctctgccgt gtgacaggtg tgtgcggagc ccaagatgtg ttgggaacag      480

ctatcgtttc tactgctttg tcccatgcct ctggagctcc tgngttcctg aacttcatgc      540

tgggccccat ccttcaccct atcagggccc tgggtggagc tgacttccaa cagtatacag      600

tgggtcttgg tacttcctcc ttggcattcg acagttggtg tttttgagtc agagccatcc      660

tcagtaggct cctagnggat cgtaagcggc tttctctggg tggaaaccta ctccatgcag      720

ccttcagcaa aggtaccagc atctgtcact gggatgggga agtccggtga tcgtgtcagc      780

atgggctacg gtggacgggg aaaggctcgt tctgacacta gacacctggg tctctagccc      840

tatgcctgga tttgtctggg gaactctgca ccacactgat cctggctttc cccattacct      900

gctccatgcc aggatcctac ggctgttgat cccctcggaa gtgagacata atgtcccgga      960

gcagatgctg atggggactc actgttgggc cacctgattt ctgtgttcat cttcccaggc     1020

tccacctttc agatcccatc cctggtgtct gcagttacaa ctttactaac cagaactttg     1080

tttccagctt acgctgaaaa gcaaagggtg acttagaata aaaatgtaac aaatagcccc     1140

atagcccaaa ccttttctgc catgatttac tgtaccagat acctataagt gtccagggca     1200

aattaaacac atcaataaat ggctttcttg tgtc                                 1234


<210>  6
<211>  1365
<212>  DNA
<213>  Mus musculus

<400>  6
gaccccgctc caccctccgt accacgtggg ccaggcgccc cgcagcctga tccctcggct       60

gaggcggggt cagagggcta agggtgactg actgcccagt gcatggatct cagcagcacg      120

gcttgacttt cgggcggcag gcaaggatgc taatccacaa ggttcctgag tccaacatcc      180

ctccctccaa tgtggggctc gaatccgcta ttgcaaccaa acccgggttc tgcccgcagg      240

gtggcgcaat gacaagagcc accaggtgac cctggtaact cccgcaccta gacctacagg      300

agcagttttt ctgcagcacc acatctgtag ccctgcatgc cgctggctcc agtgttgtgt      360

gtgtggtcat gctccatcca gcccagcagc aactttggtg tttgacaccc ctcgggaggc      420

accgctttgg aagagactgg taacagcagg gtgggaccgg ctacttagct gttctcagtc      480

tgaaaggatt ctggaaaggg gctctattta acccaagcac tggagtccaa cacagcctct      540

gccgtgtgac aggtgtgtgc ggagcccaag atgtgttggg aacagctatc gtttctactg      600

ctttgtccca tgcctctgga gctcctgggt tcctgaactt caagctgggc cccatccttc      660

accctatcag ggccctgggt ggagctgact tccaacagta tacagtgggt cttggtactt      720

cctccttggc attcgacagt tggtgttttt gaagtcagag ccatcctcag taggctccta      780

ggggatcgta agcggctttc tctgggtgga aacctactcc atgcagcctt cagcaaaggt      840

accagcatct gtcactggga tggggaagtc cggtgatcgt gtcagcatgg gctacggtgg      900

acggggaaag gctcgttctg acactagaca cctgggtctc tagccctatg cctggatttg      960

tctggggaac tctgcaccac actgatcctg gctttcccca ttacctgctc catgccagga     1020

tcctacggct gttgatcccc tcggaagtga gacataatgt cccggagcag atgctgatgg     1080

ggactcactg ttgggccacc tgatttctgt gttcatcttc ccaggctcca cctttcagat     1140

cccatccctg gtgtctgcag ttacaacttt actaaccaga actttgtttc cagcttacgc     1200

tgaaaagcaa agggtgactt agaataaaaa tgtaacaaat agccccatag cccaaacctt     1260

ttctgccatg atttactgta ccagatacct ataagtgtcc agggcaaatt aaacacatca     1320

ataaatggct ttcttgtgtc tgtcctgcaa aaaaaaaaaa aaaaa                     1365


<210>  7
<211>  1234
<212>  DNA
<213>  Artificial sequence

<220>
<223>  5x MRE mutant used in the Examples

<400>  7
gatctcagca gcacggcttg actttcgggc ggcaggcaag gatgctaatc cacaaggttc       60

ctgagtccaa catccctccc tccaatgtgg ggctcgaatc cgctattgca accaaacccg      120

ggttctgccc gcagggtggc gcaatgacaa gagccaccag gtgaccctgg taactcccgc      180

acctagacct acaggagcag tttttctgca gcaccacatc tgtagccctg catgccgctg      240

gctccagtgt tgtgtgtgtg gtcatgctcc atccagccca gcagcaactt tggtgtttga      300

cacccctcgg gaggcaccgc tttggaagag actggtagac gacaggtggg accggctact      360

tagctgttct cagtctgaaa ggattctgga aaggggctct atttaaccca agcactggag      420

tccaacacag cctctgccgt gtgacaggtg tgtgcggagc ccaagatgtg ttgggaacag      480

ctatcgtttc tactgctttg tcccatgcct cttcctcgag ggggttcctg aacttcatgc      540

tgggccccat ccttcaccct atcagggccc tgggtggagc tgacttccaa cagtatacag      600

tgggtcttgg tacttcctcc ttggcattcg acagttggtg tttttgagtc agagccatcc      660

tcagttcctc ggaaggggat cgtaagcggc tttctctggg tggaaaccta ctccatgcag      720

ccttcagcaa agcgaccatg atctgtcact gggatgggga agtccggtga tcgtgtcagc      780

atgggctacg gtggacgggg aaaggctcgt tctgacacta gacacctggg tctctagccc      840

tatgcctgga tttgtctggg gaactctgca ccacactgat cctggctttc cccattacct      900

gctccatgcc aggatcctac ggctgttgat cccctcggaa gtgagacata atgtcccgga      960

gcagatgctg atggggactc actgttgggc cacctgattt ctgtgttcat cttcccaggc     1020

tccaactttc cgatcccatc cctggtgtct gcagttacaa ctttactaac cagaactttg     1080

tttccagctt acgctgaaaa gcaaagggtg acttagaata aaaatgtaac aaatagcccc     1140

atagcccaaa ccttttctgc catgatttac tgtaccagat acctataagt gtccagggca     1200

aattaaacac atcaataaat ggctttcttg tgtc                                 1234


