                         SEQUENCE LISTING

<110>  MEDIMMUNE LLC
 
<120>  ASSAY TO DETECT HUMAN DPP-4 

<130>  DPP4-100P1

<140>  
<141>  

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  445
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(445)
<223>  Lebrikizumab Heavy chain

<400>  1

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ala Tyr 
            20                  25                  30          


Ser Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Ala Met Ile Trp Gly Asp Gly Lys Ile Val Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu 
65                  70                  75                  80  


Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Gly Asp Gly Tyr Tyr Pro Tyr Ala Met Asp Asn Trp Gly Gln Gly Ser 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 


<210>  2
<211>  218
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(218)
<223>  Lebrikizumab Light chain

<400>  2

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  3
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(122)
<223>  Tralokinumab Heavy chain

<400>  3

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Asn Asn Gly Asp Thr Asn Tyr Gly Gln Glu Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  4
<211>  108
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(108)
<223>  Tralokinumab Light chain

<400>  4

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Ile Ile Gly Ser Lys Leu Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Gly Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Gly Ser Asp Pro 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  5
<211>  766
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(766)
<223>  DPP4 membrane bound form

<400>  5

Met Lys Thr Pro Trp Lys Val Leu Leu Gly Leu Leu Gly Ala Ala Ala 
1               5                   10                  15      


Leu Val Thr Ile Ile Thr Val Pro Val Val Leu Leu Asn Lys Gly Thr 
            20                  25                  30          


Asp Asp Ala Thr Ala Asp Ser Arg Lys Thr Tyr Thr Leu Thr Asp Tyr 
        35                  40                  45              


Leu Lys Asn Thr Tyr Arg Leu Lys Leu Tyr Ser Leu Arg Trp Ile Ser 
    50                  55                  60                  


Asp His Glu Tyr Leu Tyr Lys Gln Glu Asn Asn Ile Leu Val Phe Asn 
65                  70                  75                  80  


Ala Glu Tyr Gly Asn Ser Ser Val Phe Leu Glu Asn Ser Thr Phe Asp 
                85                  90                  95      


Glu Phe Gly His Ser Ile Asn Asp Tyr Ser Ile Ser Pro Asp Gly Gln 
            100                 105                 110         


Phe Ile Leu Leu Glu Tyr Asn Tyr Val Lys Gln Trp Arg His Ser Tyr 
        115                 120                 125             


Thr Ala Ser Tyr Asp Ile Tyr Asp Leu Asn Lys Arg Gln Leu Ile Thr 
    130                 135                 140                 


Glu Glu Arg Ile Pro Asn Asn Thr Gln Trp Val Thr Trp Ser Pro Val 
145                 150                 155                 160 


Gly His Lys Leu Ala Tyr Val Trp Asn Asn Asp Ile Tyr Val Lys Ile 
                165                 170                 175     


Glu Pro Asn Leu Pro Ser Tyr Arg Ile Thr Trp Thr Gly Lys Glu Asp 
            180                 185                 190         


Ile Ile Tyr Asn Gly Ile Thr Asp Trp Val Tyr Glu Glu Glu Val Phe 
        195                 200                 205             


Ser Ala Tyr Ser Ala Leu Trp Trp Ser Pro Asn Gly Thr Phe Leu Ala 
    210                 215                 220                 


Tyr Ala Gln Phe Asn Asp Thr Glu Val Pro Leu Ile Glu Tyr Ser Phe 
225                 230                 235                 240 


Tyr Ser Asp Glu Ser Leu Gln Tyr Pro Lys Thr Val Arg Val Pro Tyr 
                245                 250                 255     


Pro Lys Ala Gly Ala Val Asn Pro Thr Val Lys Phe Phe Val Val Asn 
            260                 265                 270         


Thr Asp Ser Leu Ser Ser Val Thr Asn Ala Thr Ser Ile Gln Ile Thr 
        275                 280                 285             


Ala Pro Ala Ser Met Leu Ile Gly Asp His Tyr Leu Cys Asp Val Thr 
    290                 295                 300                 


Trp Ala Thr Gln Glu Arg Ile Ser Leu Gln Trp Leu Arg Arg Ile Gln 
305                 310                 315                 320 


Asn Tyr Ser Val Met Asp Ile Cys Asp Tyr Asp Glu Ser Ser Gly Arg 
                325                 330                 335     


Trp Asn Cys Leu Val Ala Arg Gln His Ile Glu Met Ser Thr Thr Gly 
            340                 345                 350         


Trp Val Gly Arg Phe Arg Pro Ser Glu Pro His Phe Thr Leu Asp Gly 
        355                 360                 365             


Asn Ser Phe Tyr Lys Ile Ile Ser Asn Glu Glu Gly Tyr Arg His Ile 
    370                 375                 380                 


Cys Tyr Phe Gln Ile Asp Lys Lys Asp Cys Thr Phe Ile Thr Lys Gly 
385                 390                 395                 400 


Thr Trp Glu Val Ile Gly Ile Glu Ala Leu Thr Ser Asp Tyr Leu Tyr 
                405                 410                 415     


Tyr Ile Ser Asn Glu Tyr Lys Gly Met Pro Gly Gly Arg Asn Leu Tyr 
            420                 425                 430         


Lys Ile Gln Leu Ser Asp Tyr Thr Lys Val Thr Cys Leu Ser Cys Glu 
        435                 440                 445             


Leu Asn Pro Glu Arg Cys Gln Tyr Tyr Ser Val Ser Phe Ser Lys Glu 
    450                 455                 460                 


Ala Lys Tyr Tyr Gln Leu Arg Cys Ser Gly Pro Gly Leu Pro Leu Tyr 
465                 470                 475                 480 


Thr Leu His Ser Ser Val Asn Asp Lys Gly Leu Arg Val Leu Glu Asp 
                485                 490                 495     


Asn Ser Ala Leu Asp Lys Met Leu Gln Asn Val Gln Met Pro Ser Lys 
            500                 505                 510         


Lys Leu Asp Phe Ile Ile Leu Asn Glu Thr Lys Phe Trp Tyr Gln Met 
        515                 520                 525             


Ile Leu Pro Pro His Phe Asp Lys Ser Lys Lys Tyr Pro Leu Leu Leu 
    530                 535                 540                 


Asp Val Tyr Ala Gly Pro Cys Ser Gln Lys Ala Asp Thr Val Phe Arg 
545                 550                 555                 560 


Leu Asn Trp Ala Thr Tyr Leu Ala Ser Thr Glu Asn Ile Ile Val Ala 
                565                 570                 575     


Ser Phe Asp Gly Arg Gly Ser Gly Tyr Gln Gly Asp Lys Ile Met His 
            580                 585                 590         


Ala Ile Asn Arg Arg Leu Gly Thr Phe Glu Val Glu Asp Gln Ile Glu 
        595                 600                 605             


Ala Ala Arg Gln Phe Ser Lys Met Gly Phe Val Asp Asn Lys Arg Ile 
    610                 615                 620                 


Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Thr Ser Met Val Leu 
625                 630                 635                 640 


Gly Ser Gly Ser Gly Val Phe Lys Cys Gly Ile Ala Val Ala Pro Val 
                645                 650                 655     


Ser Arg Trp Glu Tyr Tyr Asp Ser Val Tyr Thr Glu Arg Tyr Met Gly 
            660                 665                 670         


Leu Pro Thr Pro Glu Asp Asn Leu Asp His Tyr Arg Asn Ser Thr Val 
        675                 680                 685             


Met Ser Arg Ala Glu Asn Phe Lys Gln Val Glu Tyr Leu Leu Ile His 
    690                 695                 700                 


Gly Thr Ala Asp Asp Asn Val His Phe Gln Gln Ser Ala Gln Ile Ser 
705                 710                 715                 720 


Lys Ala Leu Val Asp Val Gly Val Asp Phe Gln Ala Met Trp Tyr Thr 
                725                 730                 735     


Asp Glu Asp His Gly Ile Ala Ser Ser Thr Ala His Gln His Ile Tyr 
            740                 745                 750         


Thr His Met Ser His Phe Ile Lys Gln Cys Phe Ser Leu Pro 
        755                 760                 765     


<210>  6
<211>  728
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(728)
<223>  DPP4 soluble form

<400>  6

Ser Arg Lys Thr Tyr Thr Leu Thr Asp Tyr Leu Lys Asn Thr Tyr Arg 
1               5                   10                  15      


Leu Lys Leu Tyr Ser Leu Arg Trp Ile Ser Asp His Glu Tyr Leu Tyr 
            20                  25                  30          


Lys Gln Glu Asn Asn Ile Leu Val Phe Asn Ala Glu Tyr Gly Asn Ser 
        35                  40                  45              


Ser Val Phe Leu Glu Asn Ser Thr Phe Asp Glu Phe Gly His Ser Ile 
    50                  55                  60                  


Asn Asp Tyr Ser Ile Ser Pro Asp Gly Gln Phe Ile Leu Leu Glu Tyr 
65                  70                  75                  80  


Asn Tyr Val Lys Gln Trp Arg His Ser Tyr Thr Ala Ser Tyr Asp Ile 
                85                  90                  95      


Tyr Asp Leu Asn Lys Arg Gln Leu Ile Thr Glu Glu Arg Ile Pro Asn 
            100                 105                 110         


Asn Thr Gln Trp Val Thr Trp Ser Pro Val Gly His Lys Leu Ala Tyr 
        115                 120                 125             


Val Trp Asn Asn Asp Ile Tyr Val Lys Ile Glu Pro Asn Leu Pro Ser 
    130                 135                 140                 


Tyr Arg Ile Thr Trp Thr Gly Lys Glu Asp Ile Ile Tyr Asn Gly Ile 
145                 150                 155                 160 


Thr Asp Trp Val Tyr Glu Glu Glu Val Phe Ser Ala Tyr Ser Ala Leu 
                165                 170                 175     


Trp Trp Ser Pro Asn Gly Thr Phe Leu Ala Tyr Ala Gln Phe Asn Asp 
            180                 185                 190         


Thr Glu Val Pro Leu Ile Glu Tyr Ser Phe Tyr Ser Asp Glu Ser Leu 
        195                 200                 205             


Gln Tyr Pro Lys Thr Val Arg Val Pro Tyr Pro Lys Ala Gly Ala Val 
    210                 215                 220                 


Asn Pro Thr Val Lys Phe Phe Val Val Asn Thr Asp Ser Leu Ser Ser 
225                 230                 235                 240 


Val Thr Asn Ala Thr Ser Ile Gln Ile Thr Ala Pro Ala Ser Met Leu 
                245                 250                 255     


Ile Gly Asp His Tyr Leu Cys Asp Val Thr Trp Ala Thr Gln Glu Arg 
            260                 265                 270         


Ile Ser Leu Gln Trp Leu Arg Arg Ile Gln Asn Tyr Ser Val Met Asp 
        275                 280                 285             


Ile Cys Asp Tyr Asp Glu Ser Ser Gly Arg Trp Asn Cys Leu Val Ala 
    290                 295                 300                 


Arg Gln His Ile Glu Met Ser Thr Thr Gly Trp Val Gly Arg Phe Arg 
305                 310                 315                 320 


Pro Ser Glu Pro His Phe Thr Leu Asp Gly Asn Ser Phe Tyr Lys Ile 
                325                 330                 335     


Ile Ser Asn Glu Glu Gly Tyr Arg His Ile Cys Tyr Phe Gln Ile Asp 
            340                 345                 350         


Lys Lys Asp Cys Thr Phe Ile Thr Lys Gly Thr Trp Glu Val Ile Gly 
        355                 360                 365             


Ile Glu Ala Leu Thr Ser Asp Tyr Leu Tyr Tyr Ile Ser Asn Glu Tyr 
    370                 375                 380                 


Lys Gly Met Pro Gly Gly Arg Asn Leu Tyr Lys Ile Gln Leu Ser Asp 
385                 390                 395                 400 


Tyr Thr Lys Val Thr Cys Leu Ser Cys Glu Leu Asn Pro Glu Arg Cys 
                405                 410                 415     


Gln Tyr Tyr Ser Val Ser Phe Ser Lys Glu Ala Lys Tyr Tyr Gln Leu 
            420                 425                 430         


Arg Cys Ser Gly Pro Gly Leu Pro Leu Tyr Thr Leu His Ser Ser Val 
        435                 440                 445             


Asn Asp Lys Gly Leu Arg Val Leu Glu Asp Asn Ser Ala Leu Asp Lys 
    450                 455                 460                 


Met Leu Gln Asn Val Gln Met Pro Ser Lys Lys Leu Asp Phe Ile Ile 
465                 470                 475                 480 


Leu Asn Glu Thr Lys Phe Trp Tyr Gln Met Ile Leu Pro Pro His Phe 
                485                 490                 495     


Asp Lys Ser Lys Lys Tyr Pro Leu Leu Leu Asp Val Tyr Ala Gly Pro 
            500                 505                 510         


Cys Ser Gln Lys Ala Asp Thr Val Phe Arg Leu Asn Trp Ala Thr Tyr 
        515                 520                 525             


Leu Ala Ser Thr Glu Asn Ile Ile Val Ala Ser Phe Asp Gly Arg Gly 
    530                 535                 540                 


Ser Gly Tyr Gln Gly Asp Lys Ile Met His Ala Ile Asn Arg Arg Leu 
545                 550                 555                 560 


Gly Thr Phe Glu Val Glu Asp Gln Ile Glu Ala Ala Arg Gln Phe Ser 
                565                 570                 575     


Lys Met Gly Phe Val Asp Asn Lys Arg Ile Ala Ile Trp Gly Trp Ser 
            580                 585                 590         


Tyr Gly Gly Tyr Val Thr Ser Met Val Leu Gly Ser Gly Ser Gly Val 
        595                 600                 605             


Phe Lys Cys Gly Ile Ala Val Ala Pro Val Ser Arg Trp Glu Tyr Tyr 
    610                 615                 620                 


Asp Ser Val Tyr Thr Glu Arg Tyr Met Gly Leu Pro Thr Pro Glu Asp 
625                 630                 635                 640 


Asn Leu Asp His Tyr Arg Asn Ser Thr Val Met Ser Arg Ala Glu Asn 
                645                 650                 655     


Phe Lys Gln Val Glu Tyr Leu Leu Ile His Gly Thr Ala Asp Asp Asn 
            660                 665                 670         


Val His Phe Gln Gln Ser Ala Gln Ile Ser Lys Ala Leu Val Asp Val 
        675                 680                 685             


Gly Val Asp Phe Gln Ala Met Trp Tyr Thr Asp Glu Asp His Gly Ile 
    690                 695                 700                 


Ala Ser Ser Thr Ala His Gln His Ile Tyr Thr His Met Ser His Phe 
705                 710                 715                 720 


Ile Lys Gln Cys Phe Ser Leu Pro 
                725             


<210>  7
<211>  3913
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(766)
<223>  DPP4 membrane bound form (full sequence), cDNA

<400>  7

ctttcactgg caagagacgg agtcctgggt ttcagttcca gttgcctgcg gtgggctgtg       60

tgagtttgcc aaagtcccct gccctctctg ggtctcggtt ccctcgcctg tccacgtgag      120

gttggaggag ctgaacgccg acgtcatttt tagctaagag ggagcagggt ccccgagtcg      180

ccggcccagg gtctgcgcat ccgaggccgc gcgccctttc ccctccccca cggctcctcc      240

gggccccgca ctctgcgccc cggctgccgc ccagcgccct acaccgccct cagggggccc      300

tcgcgggctc cccccggccg ggatgccagt gccccgcgcc acgcgcgcct gctcccgcgc      360

cgcctgccct gcagcctgcc cgcggcgcct ttatacccag cgggctcggc gctcactaat      420

gtttaactcg gggccgaaac ttgccagcgg cgagtgactc caccgcccgg agcagcggtg      480

caggacgcgc gtctccgccg cccgcggtga cttctgcctg cgctccttct ctgaacgctc      540

acttccgagg agacgccgac gatgaagaca ccgtggaagg ttcttctggg actgctgggt      600

gctgctgcgc ttgtcaccat catcaccgtg cccgtggttc tgctgaacaa aggcacagat      660

gatgctacag ctgacagtcg caaaacttac actctaactg attacttaaa aaatacttat      720

agactgaagt tatactcctt aagatggatt tcagatcatg aatatctcta caaacaagaa      780

aataatatct tggtattcaa tgctgaatat ggaaacagct cagttttctt ggagaacagt      840

acatttgatg agtttggaca ttctatcaat gattattcaa tatctcctga tgggcagttt      900

attctcttag aatacaacta cgtgaagcaa tggaggcatt cctacacagc ttcatatgac      960

atttatgatt taaataaaag gcagctgatt acagaagaga ggattccaaa caacacacag     1020

tgggtcacat ggtcaccagt gggtcataaa ttggcatatg tttggaacaa tgacatttat     1080

gttaaaattg aaccaaattt accaagttac agaatcacat ggacggggaa agaagatata     1140

atatataatg gaataactga ctgggtttat gaagaggaag tcttcagtgc ctactctgct     1200

ctgtggtggt ctccaaacgg cactttttta gcatatgccc aatttaacga cacagaagtc     1260

ccacttattg aatactcctt ctactctgat gagtcactgc agtacccaaa gactgtacgg     1320

gttccatatc caaaggcagg agctgtgaat ccaactgtaa agttctttgt tgtaaataca     1380

gactctctca gctcagtcac caatgcaact tccatacaaa tcactgctcc tgcttctatg     1440

ttgatagggg atcactactt gtgtgatgtg acatgggcaa cacaagaaag aatttctttg     1500

cagtggctca ggaggattca gaactattcg gtcatggata tttgtgacta tgatgaatcc     1560

agtggaagat ggaactgctt agtggcacgg caacacattg aaatgagtac tactggctgg     1620

gttggaagat ttaggccttc agaacctcat tttacccttg atggtaatag cttctacaag     1680

atcatcagca atgaagaagg ttacagacac atttgctatt tccaaataga taaaaaagac     1740

tgcacattta ttacaaaagg cacctgggaa gtcatcggga tagaagctct aaccagtgat     1800

tatctatact acattagtaa tgaatataaa ggaatgccag gaggaaggaa tctttataaa     1860

atccaactta gtgactatac aaaagtgaca tgcctcagtt gtgagctgaa tccggaaagg     1920

tgtcagtact attctgtgtc attcagtaaa gaggcgaagt attatcagct gagatgttcc     1980

ggtcctggtc tgcccctcta tactctacac agcagcgtga atgataaagg gctgagagtc     2040

ctggaagaca attcagcttt ggataaaatg ctgcagaatg tccagatgcc ctccaaaaaa     2100

ctggacttca ttattttgaa tgaaacaaaa ttttggtatc agatgatctt gcctcctcat     2160

tttgataaat ccaagaaata tcctctacta ttagatgtgt atgcaggccc atgtagtcaa     2220

aaagcagaca ctgtcttcag actgaactgg gccacttacc ttgcaagcac agaaaacatt     2280

atagtagcta gctttgatgg cagaggaagt ggttaccaag gagataagat catgcatgca     2340

atcaacagaa gactgggaac atttgaagtt gaagatcaaa ttgaagcagc cagacaattt     2400

tcaaaaatgg gatttgtgga caacaaacga attgcaattt ggggctggtc atatggaggg     2460

tacgtaacct caatggtcct gggatcggga agtggcgtgt tcaagtgtgg aatagccgtg     2520

gcgcctgtat cccggtggga gtactatgac tcagtgtaca cagaacgtta catgggtctc     2580

ccaactccag aagacaacct tgaccattac agaaattcaa cagtcatgag cagagctgaa     2640

aattttaaac aagttgagta cctccttatt catggaacag cagatgataa cgttcacttt     2700

cagcagtcag ctcagatctc caaagccctg gtcgatgttg gagtggattt ccaggcaatg     2760

tggtatactg atgaagacca tggaatagct agcagcacag cacaccaaca tatatatacc     2820

cacatgagcc acttcataaa acaatgtttc tctttacctt agcacctcaa aataccatgc     2880

catttaaagc ttattaaaac tcatttttgt tttcattatc tcaaaactgc actgtcaaga     2940

tgatgatgat ctttaaaata cacactcaaa tcaagaaact taaggttacc tttgttccca     3000

aatttcatac ctatcatctt aagtagggac ttctgtcttc acaacagatt attaccttac     3060

agaagtttga attatccggt cgggttttat tgtttaaaat catttctgca tcagctgctg     3120

aaacaacaaa taggaattgt ttttatggag gctttgcata gattccctga gcaggatttt     3180

aatctttttc taactggact ggttcaaatg ttgttctctt ctttaaaggg atggcaagat     3240

gtgggcagtg atgtcactag ggcagggaca ggataagagg gattagggag agaagatagc     3300

agggcatggc tgggaaccca agtccaagca taccaacacg agcaggctac tgtcagctcc     3360

cctcggagaa gagctgttca cagccagact ggcacagttt tctgagaaag actattcaaa     3420

cagtctcagg aaatcaaata tgcaaagcac tgacttctaa gtaaaaccac agcagttgaa     3480

aagactccaa agaaatgtaa gggaaactgc cagcaacgca ggcccccagg tgccagttat     3540

ggctataggt gctacaaaaa cacagcaagg gtgatgggaa agcattgtaa atgtgctttt     3600

aaaaaaaaat actgatgttc ctagtgaaag aggcagcttg aaactgagat gtgaacacat     3660

cagcttgccc tgttaaaaga tgaaaatatt tgtatcacaa atcttaactt gaaggagtcc     3720

ttgcatcaat ttttcttatt tcatttcttt gagtgtctta attaaaagaa tattttaact     3780

tccttggact cattttaaaa aatggaacat aaaatacaat gttatgtatt attattccca     3840

ttctacatac tatggaattt ctcccagtca tttaataaat gtgccttcat tttttcagaa     3900

aaaaaaaaaa aaa                                                        3913

  
