
                                SEQUENCE LISTING

<110> FELDMAN, Igor
      NOVOBRANTSEVA, Tatiana
      WONG, Jamie
      PHENNICIE, Ryan
      SAZINSKY, Stephen
      SATHYANARAYANAN, Sriram

<120> ANTIBODIES THAT INHIBIT TIM-3:LILRB2
  INTERACTIONS AND USES THEREOF

<130> 739512000140

<140> Not Yet Assigned    
<141> Concurrently Herewith

<150> 62/256,054          
<151> 2015-11-16 

<150> 62/141,794          
<151> 2015-04-01  

<150> 62/100,024          
<151> 2015-01-05  

<160> 102

<170> FastSEQ for Windows Version 4.0

<210> 1 
<211> 301
<212> PRT
<213> Homo sapiens

<400> 1 
Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu
 1               5                  10                  15      
Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln
            20                  25                  30          
Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu
        35                  40                  45              
Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly
    50                  55                  60                  
Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser
65                  70                  75                  80  
Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr
                85                  90                  95      
Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile
            100                 105                 110         
Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val
        115                 120                 125             
Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe
    130                 135                 140                 
Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala
145                 150                 155                 160 
Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile
                165                 170                 175     
Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu
            180                 185                 190         
Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly
        195                 200                 205             
Ile Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe
    210                 215                 220                 
Lys Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile
225                 230                 235                 240 
Ser Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu
                245                 250                 255     
Gly Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr
            260                 265                 270         
Glu Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln
        275                 280                 285             
Gln Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro
    290                 295                 300     


<210> 2 
<211> 2448
<212> DNA
<213> Homo sapiens

<400> 2 
agaacactta caggatgtgt gtagtgtggc atgacagaga actttggttt cctttaatgt 60
gactgtagac ctggcagtgt tactataaga atcactggca atcagacacc cgggtgtgct 120
gagctagcac tcagtggggg cggctactgc tcatgtgatt gtggagtaga cagttggaag 180
aagtacccag tccatttgga gagttaaaac tgtgcctaac agaggtgtcc tctgactttt 240
cttctgcaag ctccatgttt tcacatcttc cctttgactg tgtcctgctg ctgctgctgc 300
tactacttac aaggtcctca gaagtggaat acagagcgga ggtcggtcag aatgcctatc 360
tgccctgctt ctacacccca gccgccccag ggaacctcgt gcccgtctgc tggggcaaag 420
gagcctgtcc tgtgtttgaa tgtggcaacg tggtgctcag gactgatgaa agggatgtga 480
attattggac atccagatac tggctaaatg gggatttccg caaaggagat gtgtccctga 540
ccatagagaa tgtgactcta gcagacagtg ggatctactg ctgccggatc caaatcccag 600
gcataatgaa tgatgaaaaa tttaacctga agttggtcat caaaccagcc aaggtcaccc 660
ctgcaccgac tcggcagaga gacttcactg cagcctttcc aaggatgctt accaccaggg 720
gacatggccc agcagagaca cagacactgg ggagcctccc tgatataaat ctaacacaaa 780
tatccacatt ggccaatgag ttacgggact ctagattggc caatgactta cgggactctg 840
gagcaaccat cagaataggc atctacatcg gagcagggat ctgtgctggg ctggctctgg 900
ctcttatctt cggcgcttta attttcaaat ggtattctca tagcaaagag aagatacaga 960
atttaagcct catctctttg gccaacctcc ctccctcagg attggcaaat gcagtagcag 1020
agggaattcg ctcagaagaa aacatctata ccattgaaga gaacgtatat gaagtggagg 1080
agcccaatga gtattattgc tatgtcagca gcaggcagca accctcacaa cctttgggtt 1140
gtcgctttgc aatgccatag atccaaccac cttatttttg agcttggtgt tttgtctttt 1200
tcagaaacta tgagctgtgt cacctgactg gttttggagg ttctgtccac tgctatggag 1260
cagagttttc ccattttcag aagataatga ctcacatggg aattgaactg ggacctgcac 1320
tgaacttaaa caggcatgtc attgcctctg tatttaagcc aacagagtta cccaacccag 1380
agactgttaa tcatggatgt tagagctcaa acgggctttt atatacacta ggaattcttg 1440
acgtggggtc tctggagctc caggaaattc gggcacatca tatgtccatg aaacttcaga 1500
taaactaggg aaaactgggt gctgaggtga aagcataact tttttggcac agaaagtcta 1560
aaggggccac tgattttcaa agagatctgt gatccctttt tgttttttgt ttttgagatg 1620
gagtcttgct ctgttgccca ggctggagtg caatggcaca atctcggctc actgcaagct 1680
ccgcctcctg ggttcaagcg attctcctgc ctcagcctcc tgagtggctg ggattacagg 1740
catgcaccac catgcccagc taatttgttg tatttttagt agagacaggg tttcaccatg 1800
ttggccagtg tggtctcaaa ctcctgacct catgatttgc ctgcctcggc ctcccaaagc 1860
actgggatta caggcgtgag ccaccacatc cagccagtga tccttaaaag attaagagat 1920
gactggacca ggtctacctt gatcttgaag attcccttgg aatgttgaga tttaggctta 1980
tttgagcact gcctgcccaa ctgtcagtgc cagtgcatag cccttctttt gtctccctta 2040
tgaagactgc cctgcagggc tgagatgtgg caggagctcc cagggaaaaa cgaagtgcat 2100
ttgattggtg tgtattggcc aagttttgct tgttgtgtgc ttgaaagaaa atatctctga 2160
ccaacttctg tattcgtgga ccaaactgaa gctatatttt tcacagaaga agaagcagtg 2220
acggggacac aaattctgtt gcctggtgga aagaaggcaa aggccttcag caatctatat 2280
taccagcgct ggatcctttg acagagagtg gtccctaaac ttaaatttca agacggtata 2340
ggcttgatct gtcttgctta ttgttgcccc ctgcgcctag cacaattctg acacacaatt 2400
ggaacttact aaaaattttt ttttactgtt aaaaaaaaaa aaaaaaaa              2448

<210> 3 
<211> 142
<212> PRT
<213> Homo sapiens

<400> 3 
Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu
 1               5                  10                  15      
Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln
            20                  25                  30          
Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu
        35                  40                  45              
Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly
    50                  55                  60                  
Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser
65                  70                  75                  80  
Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr
                85                  90                  95      
Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile
            100                 105                 110         
Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val
        115                 120                 125             
Ile Lys Pro Gly Glu Trp Thr Phe Ala Cys His Leu Tyr Glu
    130                 135                 140         


<210> 4 
<211> 1012
<212> DNA
<213> Homo sapiens

<400> 4 
actgctcatg tgattgtgga gtagacagtt ggaagaagta cccagtccat ttggagagtt 60
aaaactgtgc ctaacagagg tgtcctctga cttttcttct gcaagctcca tgttttcaca 120
tcttcccttt gactgtgtcc tgctgctgct gctgctacta cttacaaggt cctcagaagt 180
ggaatacaga gcggaggtcg gtcagaatgc ctatctgccc tgcttctaca ccccagccgc 240
cccagggaac ctcgtgcccg tctgctgggg caaaggagcc tgtcctgtgt ttgaatgtgg 300
caacgtggtg ctcaggactg atgaaaggga tgtgaattat tggacatcca gatactggct 360
aaatggggat ttccgcaaag gagatgtgtc cctgaccata gagaatgtga ctctagcaga 420
cagtgggatc tactgctgcc ggatccaaat cccaggcata atgaatgatg aaaaatttaa 480
cctgaagttg gtcatcaaac caggtgagtg gacatttgca tgccatcttt atgaataaga 540
tttatctgtg gatcatatta aaggtactga ttgttctcat ctctgacttc cctaattata 600
gccctggagg agggccacta agacctaaag tttaacaggc cccattggtg atgctcagtg 660
atatttaaca ccttctctct gttttaaaac tcatgggtgt gcctgggcgt ggtggctcgc 720
gcctctggtc ccagcacttt gggaggctga ggccggtgga tcatgaggtc aggaattcga 780
gaccagcctg gccaacatgg taaaaccttg tctccactaa aaatacaaaa aattagccag 840
gcatggttac gggagcctgt aattctagct acttgggggg ctgaagcagg agaatcactt 900
gaacctggaa gtcggaggtt gcggtaagcc aagatctcgc cattgtactc cagcctggct 960
gacaagagtg aaactctgtc ccaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa         1012

<210> 5 
<211> 598
<212> PRT
<213> Homo sapiens

<400> 5 
Met Thr Pro Ile Val Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly
 1               5                  10                  15      
Pro Arg Thr Arg Val Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp
            20                  25                  30          
Ala Glu Pro Asp Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser
        35                  40                  45              
Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys
    50                  55                  60                  
Lys Ser Ala Ser Trp Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn
65                  70                  75                  80  
Gly Gln Phe His Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr
                85                  90                  95      
Gly Cys Gln Tyr Tyr Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro
            100                 105                 110         
Leu Val Leu Val Met Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala
        115                 120                 125             
Gln Pro Ser Pro Val Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys
    130                 135                 140                 
Glu Ser Gln Val Ala Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu
145                 150                 155                 160 
Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser
                165                 170                 175     
Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp
            180                 185                 190         
Ser His Arg Cys Tyr Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser
        195                 200                 205             
Ser Pro Ser Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys
    210                 215                 220                 
Pro Ser Leu Ser Val Gln Pro Gly Pro Val Met Ala Pro Gly Glu Ser
225                 230                 235                 240 
Leu Thr Leu Gln Cys Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu
                245                 250                 255     
Tyr Lys Glu Gly Glu Arg Asp Leu Arg Gln Leu Pro Gly Arg Gln Pro
            260                 265                 270         
Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg
        275                 280                 285             
Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser
    290                 295                 300                 
Glu Cys Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln
305                 310                 315                 320 
Ile Arg Gly Thr Pro Phe Ile Ser Val Gln Pro Gly Pro Thr Val Ala
                325                 330                 335     
Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Trp Arg Gln Phe His
            340                 345                 350         
Thr Phe Leu Leu Thr Lys Ala Gly Ala Ala Asp Ala Pro Leu Arg Leu
        355                 360                 365             
Arg Ser Ile His Glu Tyr Pro Lys Tyr Gln Ala Glu Phe Pro Met Ser
    370                 375                 380                 
Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Leu
385                 390                 395                 400 
Asn Ser Asp Pro Tyr Leu Leu Ser His Pro Ser Glu Pro Leu Glu Leu
                405                 410                 415     
Val Val Ser Gly Pro Ser Met Gly Ser Ser Pro Pro Pro Thr Gly Pro
            420                 425                 430         
Ile Ser Thr Pro Ala Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly
        435                 440                 445             
Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly
    450                 455                 460                 
Ile Leu Val Ala Val Val Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe
465                 470                 475                 480 
Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln
                485                 490                 495     
Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro
            500                 505                 510         
Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln
        515                 520                 525             
Glu Glu Asn Leu Tyr Ala Ala Val Lys Asp Thr Gln Pro Glu Asp Gly
    530                 535                 540                 
Val Glu Met Asp Thr Arg Ala Ala Ala Ser Glu Ala Pro Gln Asp Val
545                 550                 555                 560 
Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Lys Ala Thr Glu
                565                 570                 575     
Pro Pro Pro Ser Gln Glu Arg Glu Pro Pro Ala Glu Pro Ser Ile Tyr
            580                 585                 590         
Ala Thr Leu Ala Ile His
        595             


<210> 6 
<211> 2940
<212> DNA
<213> Homo sapiens

<400> 6 
atttggttga aagaaaaccc acaatccagt gtcaagaaag aagtcaactt ttcttcccct 60
acttccctgc atttctcctc tgtgctcact gccacacaca gctcaacctg gacagcacag 120
ccagaggcga gatgcttctc tgctgatctg agtctgcctg cagcatggac ctgggtcttc 180
cctgaagcat ctccagggct ggagggacga ctgccatgca ccgagggctc atccatccgc 240
agagcagggc agtgggagga gacgccatga cccccatcgt cacagtcctg atctgtctcg 300
ggctgagtct gggccccagg acccgcgtgc agacagggac catccccaag cccaccctgt 360
gggctgagcc agactctgtg atcacccagg ggagtcccgt caccctcagt tgtcagggga 420
gccttgaagc ccaggagtac cgtctatata gggagaaaaa atcagcatct tggattacac 480
ggatacgacc agagcttgtg aagaacggcc agttccacat cccatccatc acctgggaac 540
acacagggcg atatggctgt cagtattaca gccgcgctcg gtggtctgag ctcagtgacc 600
ccctggtgct ggtgatgaca ggagcctacc caaaacccac cctctcagcc cagcccagcc 660
ctgtggtgac ctcaggagga agggtgaccc tccagtgtga gtcacaggtg gcatttggcg 720
gcttcattct gtgtaaggaa ggagaagatg aacacccaca atgcctgaac tcccagcccc 780
atgcccgtgg gtcgtcccgc gccatcttct ccgtgggccc cgtgagcccg aatcgcaggt 840
ggtcgcacag gtgctatggt tatgacttga actctcccta tgtgtggtct tcacccagtg 900
atctcctgga gctcctggtc ccaggtgttt ctaagaagcc atcactctca gtgcagccgg 960
gtcctgtcat ggcccctggg gaaagcctga ccctccagtg tgtctctgat gtcggctatg 1020
acagatttgt tctgtacaag gagggggaac gtgaccttcg ccagctccct ggccggcagc 1080
cccaggctgg gctctcccag gccaacttca ccctgggccc tgtgagccgc tcctacgggg 1140
gccagtacag atgctacggt gcacacaacc tctcctctga gtgctcggcc cccagcgacc 1200
ccctggacat cctgatcaca ggacagatcc gtggcacacc cttcatctca gtgcagccag 1260
gccccacagt ggcctcagga gagaacgtga ccctgctgtg tcagtcatgg cggcagttcc 1320
acactttcct tctgaccaag gcgggagcag ctgatgcccc actccgtcta agatcaatac 1380
acgaatatcc taagtaccag gctgaattcc ccatgagtcc tgtgacctca gcccacgcgg 1440
ggacctacag gtgctacggc tcactcaact ccgaccccta cctgctgtct caccccagtg 1500
agcccctgga gctcgtggtc tcaggaccct ccatgggttc cagcccccca cccaccggtc 1560
ccatctccac acctgcaggc cctgaggacc agcccctcac ccccactggg tcggatcccc 1620
aaagtggtct gggaaggcac ctgggggttg tgatcggcat cttggtggcc gtcgtcctac 1680
tgctcctcct cctcctcctc ctcttcctca tcctccgaca tcgacgtcag ggcaaacact 1740
ggacatcgac ccagagaaag gctgatttcc aacatcctgc aggggctgtg gggccagagc 1800
ccacagacag aggcctgcag tggaggtcca gcccagctgc cgacgcccag gaagaaaacc 1860
tctatgctgc cgtgaaggac acacagcctg aagatggggt ggagatggac actcgggctg 1920
ctgcatctga agccccccag gatgtgacct acgcccagct gcacagcttg accctcagac 1980
ggaaggcaac tgagcctcct ccatcccagg aaagggaacc tccagctgag cccagcatct 2040
acgccaccct ggccatccac tagcccggag ggtacgcaga ctccacactc agtagaagga 2100
gactcaggac tgctgaaggc acgggagctg cccccagtgg acaccaatga accccagtca 2160
gcctggaccc ctaacaaaga ccatgaggag atgctgggaa ctttgggact cacttgattc 2220
tgcagtcgaa ataactaata tccctacatt ttttaattaa agcaacagac ttctcaataa 2280
tcaatgagtt aaccgagaaa actaaaatca gaagtaagaa tgtgctttaa actgaatcac 2340
aatataaata ttacacatca cacaatgaaa ttgaaaaagt acaaaccaca aatgaaaaaa 2400
gtagaaacga aaaaaaaaaa ctaggaaatg aatgacgttg gctttcgtat aaggaattta 2460
gaaaaagaat aaccaattat tccaaatgaa ggtgtaagaa agggaataag aagaagaaga 2520
gttgctcatg aggaaaaacc aaaacttgaa aattcaacaa agccaatgaa gctcattctt 2580
gaaaatatta attacagtca taaatcctaa ctacattgag caagagaaag aaagagcagg 2640
cacgcatttc catatgggag tgagccagca gacagcccag cagatcctac acacattttc 2700
acaaactaac cccagaacag gctgcaaacc tataccaata tactagaaaa tgcagattaa 2760
atggatgaaa tattcaaaac tggagtttac ataatgaacg taagagtaat cagagaatct 2820
gactcatttt aaatgtgtgt gtatgtgtgt gtatatatat gtgtgtgtgt gtgtgtgtgt 2880
gtgtgtgtga aaaacattga ctgtaataaa aatgttccca tcgtaaaaaa aaaaaaaaaa 2940


<210> 7 
<211> 597
<212> PRT
<213> Homo sapiens

<400> 7 
Met Thr Pro Ile Val Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly
 1               5                  10                  15      
Pro Arg Thr Arg Val Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp
            20                  25                  30          
Ala Glu Pro Asp Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser
        35                  40                  45              
Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys
    50                  55                  60                  
Lys Ser Ala Ser Trp Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn
65                  70                  75                  80  
Gly Gln Phe His Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr
                85                  90                  95      
Gly Cys Gln Tyr Tyr Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro
            100                 105                 110         
Leu Val Leu Val Met Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala
        115                 120                 125             
Gln Pro Ser Pro Val Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys
    130                 135                 140                 
Glu Ser Gln Val Ala Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu
145                 150                 155                 160 
Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser
                165                 170                 175     
Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp
            180                 185                 190         
Ser His Arg Cys Tyr Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser
        195                 200                 205             
Ser Pro Ser Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys
    210                 215                 220                 
Pro Ser Leu Ser Val Gln Pro Gly Pro Val Met Ala Pro Gly Glu Ser
225                 230                 235                 240 
Leu Thr Leu Gln Cys Val Ser Asp Val Gly Tyr Asp Arg Phe Val Leu
                245                 250                 255     
Tyr Lys Glu Gly Glu Arg Asp Leu Arg Gln Leu Pro Gly Arg Gln Pro
            260                 265                 270         
Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg
        275                 280                 285             
Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser
    290                 295                 300                 
Glu Cys Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln
305                 310                 315                 320 
Ile Arg Gly Thr Pro Phe Ile Ser Val Gln Pro Gly Pro Thr Val Ala
                325                 330                 335     
Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Trp Arg Gln Phe His
            340                 345                 350         
Thr Phe Leu Leu Thr Lys Ala Gly Ala Ala Asp Ala Pro Leu Arg Leu
        355                 360                 365             
Arg Ser Ile His Glu Tyr Pro Lys Tyr Gln Ala Glu Phe Pro Met Ser
    370                 375                 380                 
Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Leu
385                 390                 395                 400 
Asn Ser Asp Pro Tyr Leu Leu Ser His Pro Ser Glu Pro Leu Glu Leu
                405                 410                 415     
Val Val Ser Gly Pro Ser Met Gly Ser Ser Pro Pro Pro Thr Gly Pro
            420                 425                 430         
Ile Ser Thr Pro Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser
        435                 440                 445             
Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly Ile
    450                 455                 460                 
Leu Val Ala Val Val Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe Leu
465                 470                 475                 480 
Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg
                485                 490                 495     
Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr
            500                 505                 510         
Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu
        515                 520                 525             
Glu Asn Leu Tyr Ala Ala Val Lys Asp Thr Gln Pro Glu Asp Gly Val
    530                 535                 540                 
Glu Met Asp Thr Arg Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr
545                 550                 555                 560 
Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Lys Ala Thr Glu Pro
                565                 570                 575     
Pro Pro Ser Gln Glu Arg Glu Pro Pro Ala Glu Pro Ser Ile Tyr Ala
            580                 585                 590         
Thr Leu Ala Ile His
        595         


<210> 8 
<211> 2937
<212> DNA
<213> Homo sapiens

<400> 8 
atttggttga aagaaaaccc acaatccagt gtcaagaaag aagtcaactt ttcttcccct 60
acttccctgc atttctcctc tgtgctcact gccacacaca gctcaacctg gacagcacag 120
ccagaggcga gatgcttctc tgctgatctg agtctgcctg cagcatggac ctgggtcttc 180
cctgaagcat ctccagggct ggagggacga ctgccatgca ccgagggctc atccatccgc 240
agagcagggc agtgggagga gacgccatga cccccatcgt cacagtcctg atctgtctcg 300
ggctgagtct gggccccagg acccgcgtgc agacagggac catccccaag cccaccctgt 360
gggctgagcc agactctgtg atcacccagg ggagtcccgt caccctcagt tgtcagggga 420
gccttgaagc ccaggagtac cgtctatata gggagaaaaa atcagcatct tggattacac 480
ggatacgacc agagcttgtg aagaacggcc agttccacat cccatccatc acctgggaac 540
acacagggcg atatggctgt cagtattaca gccgcgctcg gtggtctgag ctcagtgacc 600
ccctggtgct ggtgatgaca ggagcctacc caaaacccac cctctcagcc cagcccagcc 660
ctgtggtgac ctcaggagga agggtgaccc tccagtgtga gtcacaggtg gcatttggcg 720
gcttcattct gtgtaaggaa ggagaagatg aacacccaca atgcctgaac tcccagcccc 780
atgcccgtgg gtcgtcccgc gccatcttct ccgtgggccc cgtgagcccg aatcgcaggt 840
ggtcgcacag gtgctatggt tatgacttga actctcccta tgtgtggtct tcacccagtg 900
atctcctgga gctcctggtc ccaggtgttt ctaagaagcc atcactctca gtgcagccgg 960
gtcctgtcat ggcccctggg gaaagcctga ccctccagtg tgtctctgat gtcggctatg 1020
acagatttgt tctgtacaag gagggggaac gtgaccttcg ccagctccct ggccggcagc 1080
cccaggctgg gctctcccag gccaacttca ccctgggccc tgtgagccgc tcctacgggg 1140
gccagtacag atgctacggt gcacacaacc tctcctctga gtgctcggcc cccagcgacc 1200
ccctggacat cctgatcaca ggacagatcc gtggcacacc cttcatctca gtgcagccag 1260
gccccacagt ggcctcagga gagaacgtga ccctgctgtg tcagtcatgg cggcagttcc 1320
acactttcct tctgaccaag gcgggagcag ctgatgcccc actccgtcta agatcaatac 1380
acgaatatcc taagtaccag gctgaattcc ccatgagtcc tgtgacctca gcccacgcgg 1440
ggacctacag gtgctacggc tcactcaact ccgaccccta cctgctgtct caccccagtg 1500
agcccctgga gctcgtggtc tcaggaccct ccatgggttc cagcccccca cccaccggtc 1560
ccatctccac acctggccct gaggaccagc ccctcacccc cactgggtcg gatccccaaa 1620
gtggtctggg aaggcacctg ggggttgtga tcggcatctt ggtggccgtc gtcctactgc 1680
tcctcctcct cctcctcctc ttcctcatcc tccgacatcg acgtcagggc aaacactgga 1740
catcgaccca gagaaaggct gatttccaac atcctgcagg ggctgtgggg ccagagccca 1800
cagacagagg cctgcagtgg aggtccagcc cagctgccga cgcccaggaa gaaaacctct 1860
atgctgccgt gaaggacaca cagcctgaag atggggtgga gatggacact cgggctgctg 1920
catctgaagc cccccaggat gtgacctacg cccagctgca cagcttgacc ctcagacgga 1980
aggcaactga gcctcctcca tcccaggaaa gggaacctcc agctgagccc agcatctacg 2040
ccaccctggc catccactag cccggagggt acgcagactc cacactcagt agaaggagac 2100
tcaggactgc tgaaggcacg ggagctgccc ccagtggaca ccaatgaacc ccagtcagcc 2160
tggaccccta acaaagacca tgaggagatg ctgggaactt tgggactcac ttgattctgc 2220
agtcgaaata actaatatcc ctacattttt taattaaagc aacagacttc tcaataatca 2280
atgagttaac cgagaaaact aaaatcagaa gtaagaatgt gctttaaact gaatcacaat 2340
ataaatatta cacatcacac aatgaaattg aaaaagtaca aaccacaaat gaaaaaagta 2400
gaaacgaaaa aaaaaaacta ggaaatgaat gacgttggct ttcgtataag gaatttagaa 2460
aaagaataac caattattcc aaatgaaggt gtaagaaagg gaataagaag aagaagagtt 2520
gctcatgagg aaaaaccaaa acttgaaaat tcaacaaagc caatgaagct cattcttgaa 2580
aatattaatt acagtcataa atcctaacta cattgagcaa gagaaagaaa gagcaggcac 2640
gcatttccat atgggagtga gccagcagac agcccagcag atcctacaca cattttcaca 2700
aactaacccc agaacaggct gcaaacctat accaatatac tagaaaatgc agattaaatg 2760
gatgaaatat tcaaaactgg agtttacata atgaacgtaa gagtaatcag agaatctgac 2820
tcattttaaa tgtgtgtgta tgtgtgtgta tatatatgtg tgtgtgtgtg tgtgtgtgtg 2880
tgtgtgaaaa acattgactg taataaaaat gttcccatcg taaaaaaaaa aaaaaaa    2937

<210> 9 
<211> 281
<212> PRT
<213> Mus musculus

<400> 9 
Met Phe Ser Gly Leu Thr Leu Asn Cys Val Leu Leu Leu Leu Gln Leu
 1               5                  10                  15      
Leu Leu Ala Arg Ser Leu Glu Asn Ala Tyr Val Phe Glu Val Gly Lys
            20                  25                  30          
Asn Ala Tyr Leu Pro Cys Ser Tyr Thr Leu Ser Thr Pro Gly Ala Leu
        35                  40                  45              
Val Pro Met Cys Trp Gly Lys Gly Phe Cys Pro Trp Ser Gln Cys Thr
    50                  55                  60                  
Asn Glu Leu Leu Arg Thr Asp Glu Arg Asn Val Thr Tyr Gln Lys Ser
65                  70                  75                  80  
Ser Arg Tyr Gln Leu Lys Gly Asp Leu Asn Lys Gly Asp Val Ser Leu
                85                  90                  95      
Ile Ile Lys Asn Val Thr Leu Asp Asp His Gly Thr Tyr Cys Cys Arg
            100                 105                 110         
Ile Gln Phe Pro Gly Leu Met Asn Asp Lys Lys Leu Glu Leu Lys Leu
        115                 120                 125             
Asp Ile Lys Ala Ala Lys Val Thr Pro Ala Gln Thr Ala His Gly Asp
    130                 135                 140                 
Ser Thr Thr Ala Ser Pro Arg Thr Leu Thr Thr Glu Arg Asn Gly Ser
145                 150                 155                 160 
Glu Thr Gln Thr Leu Val Thr Leu His Asn Asn Asn Gly Thr Lys Ile
                165                 170                 175     
Ser Thr Trp Ala Asp Glu Ile Lys Asp Ser Gly Glu Thr Ile Arg Thr
            180                 185                 190         
Ala Ile His Ile Gly Val Gly Val Ser Ala Gly Leu Thr Leu Ala Leu
        195                 200                 205             
Ile Ile Gly Val Leu Ile Leu Lys Trp Tyr Ser Cys Lys Lys Lys Lys
    210                 215                 220                 
Leu Ser Ser Leu Ser Leu Ile Thr Leu Ala Asn Leu Pro Pro Gly Gly
225                 230                 235                 240 
Leu Ala Asn Ala Gly Ala Val Arg Ile Arg Ser Glu Glu Asn Ile Tyr
                245                 250                 255     
Thr Ile Glu Glu Asn Val Tyr Glu Val Glu Asn Ser Asn Glu Tyr Tyr
            260                 265                 270         
Cys Tyr Val Asn Ser Gln Gln Pro Ser
        275                 280     


<210> 10 
<211> 2725
<212> DNA
<213> Mus musculus

<220> 
<221> allele         
<222> (0)...(0)
<223> Synthetic construct

<400> 10 
accattttaa ccgaggagct aaagctatcc ctacacagag ctgtccttgg atttcccctg 60
ccaagtactc atgttttcag gtcttaccct caactgtgtc ctgctgctgc tgcaactact 120
acttgcaagg tcattggaaa atgcttatgt gtttgaggtt ggtaagaatg cctatctgcc 180
ctgcagttac actctatcta cacctggggc acttgtgcct atgtgctggg gcaagggatt 240
ctgtccttgg tcacagtgta ccaacgagtt gctcagaact gatgaaagaa atgtgacata 300
tcagaaatcc agcagatacc agctaaaggg cgatctcaac aaaggagacg tgtctctgat 360
cataaagaat gtgactctgg atgaccatgg gacctactgc tgcaggatac agttccctgg 420
tcttatgaat gataaaaaat tagaactgaa attagacatc aaagcagcca aggtcactcc 480
agctcagact gcccatgggg actctactac agcttctcca agaaccctaa ccacggagag 540
aaatggttca gagacacaga cactggtgac cctccataat aacaatggaa caaaaatttc 600
cacatgggct gatgaaatta aggactctgg agaaacgatc agaactgcta tccacattgg 660
agtgggagtc tctgctgggt tgaccctggc acttatcatt ggtgtcttaa tccttaaatg 720
gtattcctgt aagaaaaaga agttatcgag tttgagcctt attacactgg ccaacttgcc 780
tccaggaggg ttggcaaatg caggagcagt caggattcgc tctgaggaaa atatctacac 840
catcgaggag aacgtatatg aagtggagaa ttcaaatgag tactactgct acgtcaacag 900
ccagcagcca tcctgaccgc ctctggactg ccacttttaa aggctcgcct tcatttctga 960
ctttggtatt tccctttttg aaaactatgt gatatgtcac ttggcaacct cattggaggt 1020
tctgaccaca gccactgaga aaagagttcc agttttctgg ggataattaa ctcacaaggg 1080
gattcgactg taactcatgc tacattgaaa tgctccattt tatccctgag tttcagggat 1140
cggatctccc actccagaga cttcaatcat gcgtgttgaa gctcactcgt gctttcatac 1200
attaggaatg gttagtgtga tgtctttgag acatagaggt ttgtggtata tctgcaaagc 1260
tcctgaacag gtagggggaa taaagggcta agataggaag gtgaggttct ttgttgatgt 1320
tgaaaatcta aagaagttgg tagcttttct agagatttct gaccttgaaa gattaagaaa 1380
aagccaggtg gcatatgctt aacactatat aacttgggaa ccttaggcag gagggtgata 1440
agttcaaggt cagccagggc tatgctggta agactgtctc aaaatccaaa gacgaaaata 1500
aacatagaga cagcaggagg ctggagatga ggctcggaca gtgaggtgca ttttgtacaa 1560
gcacgaggaa tctatatttg atcgtagacc ccacatgaaa aagctaggcc tggtagagca 1620
tgcttgtaga ctcaagagat ggagaggtaa aggcacaaca gatccccggg gcttgcgtgc 1680
agtcagctta gcctaggtgc tgagttccaa gtccacaaga gtccctgtct caaagtaaga 1740
tggactgagt atctggcgaa tgtccatggg ggttgtcctc tgctctcaga agagacatgc 1800
acatgaacct gcacacacac acacacacac acacacacac acacacacac acacacacac 1860
acacacatga aatgaaggtt ctctctgtgc ctgctacctc tctataacat gtatctctac 1920
aggactctcc tctgcctctg ttaagacatg agtgggagca tggcagagca gtccagtaat 1980
taattccagc actcagaagg ctggagcaga agcgtggaga gttcaggagc actgtgccca 2040
acactgccag actcttctta cagaagaaaa aggttacccg caagcagcct gctgtctgta 2100
aaaggaaacc ctgcgaaagg caaactttga ctgttgtgtg ctcaagggga actgactcag 2160
acaacttctc cattcctgga ggaaactgga gctgtttctg acagaagaac aaccggtgac 2220
tgggacatac gaaggcagag ctcttgcagc aatctatata gtcagcaaaa tattctttgg 2280
gaggacagtc gtcaccaaat tgatttccaa gccggtggac ctcagtttca tctggcttac 2340
agctgcctgc ccagtgccct tgatctgtgc tggctcccat ctataacaga atcaaattaa 2400
atagaccccg agtgaaaata ttaagtgagc agaaaggtag ctttgttcaa agattttttt 2460
gcattgggga gcaactgtgt acatcagagg acatctgtta gtgaggacac caaaacctgt 2520
ggtaccgttt tttcatgtat gaattttgtt gtttaggttg cttctagcta gctgtggagg 2580
tcctggcttt cttaggtggg tatggaaggg agaccatcta acaaaatcca ttagagataa 2640
cagctctcat gcagaaggga aaactaatct caaatgtttt aaagtaataa aactgtactg 2700
gcaaagtact ttgagcatat ttaaa                                       2725

<210> 11 
<211> 631
<212> DNA
<213> Mus musculus

<220> 
<221> allele         
<222> (0)...(0)
<223> Synthetic construct

<400> 11 
aagcagtggt atcaacgcag agtacgcggg gcatcatctt ctcatagagc ctccatcaga 60
gcatggctgt cctggcatta ctcttctgcc tggtaacatt cccaagctgt atcctttccc 120
aggtgcagct gaaggagtca ggacctggcc tggtggcgcc ctcacagagc ctgtccatca 180
catgcaccgt ctcagggttc tcattaaccg gctatggtgt tacctgggtt cgccagcctc 240
caggaaaggg tctggagtgg ctgggaatga tatggggtga tggaaacaca gactataatt 300
caggtctcaa atccagactg aacatcagca aggacaactc caagagccaa gttttcttaa 360
aaatgaacag tctgcaaact gatgacacag ccaggtacta ctgtgccagg tcttattact 420
acggtccccc tgactactgg ggccaaggca ccactctcac agtctcctca gccaaaacga 480
cacccccatc tgtctatcca ctggcccctg gatctgctgc ccaaaactaa ctccatggtg 540
accctgggat gcctggtcaa gggctatttc cctgagccag tgacagtgac ctggaactct 600
ggatccctgt ccagcggtgt gcacaccttc c                                631

<210> 12 
<211> 136
<212> PRT
<213> Mus musculus

<400> 12 
Met Ala Val Leu Ala Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys
 1               5                  10                  15      
Ile Leu Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala
            20                  25                  30          
Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu
        35                  40                  45              
Thr Gly Tyr Gly Val Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Asn Thr Asp Tyr Asn Ser
65                  70                  75                  80  
Gly Leu Lys Ser Arg Leu Asn Ile Ser Lys Asp Asn Ser Lys Ser Gln
                85                  90                  95      
Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr
            100                 105                 110         
Tyr Cys Ala Arg Ser Tyr Tyr Tyr Gly Pro Pro Asp Tyr Trp Gly Gln
        115                 120                 125             
Gly Thr Thr Leu Thr Val Ser Ser
    130                 135     


<210> 13 
<211> 507
<212> DNA
<213> Mus musculus

<400> 13 
aagcagtggt atcaacgcag agtacgcggg gcatcagaca ggctgggcag caagatggaa 60
tcacagaccc aggtcctcat gtttcttctg ctctgggtat ctggtgcctg tgcagacatt 120
gtgatgacac agtctccatc ctccctggct atgtcagtag gacagaaggt cactatgagc 180
tgcaagtcca gtcagagcct tctaaatagt agaagtcaaa agaactattt ggcctggtac 240
cagcggaaac caggacagtc tcctaaactt ctgctatact ttgcatccac tagggaatct 300
ggggtccctg atcgcttcat aggcagtgga tctgggacag atttcactct taccatcagc 360
agtgtgcagg ctgaagacct ggcagattac ttctgtcacc aacattataa cactccgtac 420
acgttcggag gggggaccaa gctggaaatt aaacgggctg atgctgcacc aactgtatcc 480
atcttcccac catccagtga gcagtta                                     507

<210> 14 
<211> 133
<212> PRT
<213> Mus musculus

<400> 14 
Met Glu Ser Gln Thr Gln Val Leu Met Phe Leu Leu Leu Trp Val Ser
 1               5                  10                  15      
Gly Ala Cys Ala Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala
            20                  25                  30          
Met Ser Val Gly Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser
        35                  40                  45              
Leu Leu Asn Ser Arg Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Arg
    50                  55                  60                  
Lys Pro Gly Gln Ser Pro Lys Leu Leu Leu Tyr Phe Ala Ser Thr Arg
65                  70                  75                  80  
Glu Ser Gly Val Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp
                85                  90                  95      
Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr
            100                 105                 110         
Phe Cys His Gln His Tyr Asn Thr Pro Tyr Thr Phe Gly Gly Gly Thr
        115                 120                 125             
Lys Leu Glu Ile Lys
    130             


<210> 15 
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 15 
Gly Phe Ser Leu Thr Gly Tyr Gly
 1               5              


<210> 16 
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 16 
Ile Trp Gly Asp Gly Asn Thr
 1               5          


<210> 17 
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 17 
Ala Arg Ser Tyr Tyr Tyr Gly Pro Pro Asp Tyr
 1               5                  10      


<210> 18 
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 18 
Gln Ser Leu Leu Asn Ser Arg Ser Gln Lys Asn Tyr
 1               5                  10          


<210> 19 
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 19 
Phe Ala Ser
 1          


<210> 20 
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 20 
His Gln His Tyr Asn Thr Pro Tyr Thr
 1               5                  


<210> 21 
<211> 118
<212> PRT
<213> Mus musculus

<400> 21 
Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Phe
                85                  90                  95      
Ala Arg Gly Gly Lys Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Ser Val Thr Val Ser Ser
        115             


<210> 22 
<211> 107
<212> PRT
<213> Mus musculus

<400> 22 
Asn Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Ile Ser Ala Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Gly Asn Asn
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
    50                  55                  60                  
Ser Ala Tyr Gly Thr Asp Phe Thr Phe Thr Ile Thr Thr Val Gln Ala
65                  70                  75                  80  
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 23 
<211> 121
<212> PRT
<213> Mus musculus

<400> 23 
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val
        35                  40                  45              
Ala Thr Ile Ser Ser Gly Gly Ser Asn Thr Tyr Phe Pro Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg His Gly Thr Ser Met Ile Lys Glu Trp Phe Ala Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ala
        115                 120     


<210> 24 
<211> 107
<212> PRT
<213> Mus musculus

<400> 24 
Asp Ile Val Met Thr Gln Ser Pro Val Thr Leu Ser Val Thr Pro Gly
 1               5                  10                  15      
Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Asp Tyr
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile
        35                  40                  45              
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Ser Asp Phe Thr Leu Asn Ile Asn Ser Val Glu Pro
65                  70                  75                  80  
Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Ser His Ser Phe Pro Pro
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys
            100                 105         


<210> 25 
<211> 121
<212> PRT
<213> Mus musculus

<400> 25 
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn His
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val
        35                  40                  45              
Ala Thr Ile Ser Ser Gly Gly Ser Asn Thr Tyr Phe Pro Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg His Gly Thr Ser Met Ile Lys Glu Trp Phe Ala Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ala
        115                 120     


<210> 26 
<211> 107
<212> PRT
<213> Mus musculus

<400> 26 
Asp Ile Val Met Thr Gln Ser Pro Val Thr Leu Ser Val Thr Pro Gly
 1               5                  10                  15      
Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Asp Tyr
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile
        35                  40                  45              
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Ser Asp Phe Thr Leu Asn Ile Asn Ser Val Glu Pro
65                  70                  75                  80  
Glu Asp Val Gly Val Tyr Tyr Cys Gln His Ser His Ser Phe Pro Pro
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys
            100                 105         


<210> 27 
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 27 
Gly Tyr Thr Phe Thr Asp Tyr Tyr Ile Asn
 1               5                  10  


<210> 28 
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 28 
Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Asn Glu Lys Phe Lys
 1               5                  10                  15      
Gly
    


<210> 29 
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 29 
Gly Gly Lys Tyr Tyr Ala Met Asp Tyr
 1               5                  


<210> 30 
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 30 
Lys Ala Ser Gln Ser Val Gly Asn Asn Val Ala
 1               5                  10      


<210> 31 
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 31 
Tyr Ala Ser Asn Arg Tyr Thr
 1               5          


<210> 32 
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 32 
Gln Gln Asp Tyr Ser Ser Pro Tyr Thr
 1               5                  


<210> 33 
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 33 
Gly Phe Thr Phe Ser Asn Tyr Gly Met Ser
 1               5                  10  


<210> 34 
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 34 
Thr Ile Ser Ser Gly Gly Ser Asn Thr Tyr Phe Pro Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 35 
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 35 
His Gly Thr Ser Met Ile Lys Glu Trp Phe Ala Tyr
 1               5                  10          


<210> 36 
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 36 
Arg Ala Ser Gln Ser Ile Gly Asp Tyr Leu His
 1               5                  10      


<210> 37 
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 37 
Tyr Ala Ser Gln Ser Ile Ser
 1               5          


<210> 38 
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 38 
Gln Asn Ser His Ser Phe Pro Pro Thr
 1               5                  


<210> 39 
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 39 
Gly Phe Thr Phe Ser Asn His Gly Met Ser
 1               5                  10  


<210> 40 
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 40 
Gln His Ser His Ser Phe Pro Pro Thr
 1               5                  


<210> 41 
<211> 121
<212> PRT
<213> Mus musculus

<400> 41 
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
            20                  25                  30          
Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Leu Met
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Ser Gly Ala Pro Thr Tyr Ala Asp Asp Phe
    50                  55                  60                  
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Ala Ala Tyr
65                  70                  75                  80  
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys
                85                  90                  95      
Ala Arg Lys Pro Pro His Tyr Tyr Val Asn Ser Phe Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Thr Leu Thr Val Ser Ser
        115                 120     


<210> 42 
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 42 
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala
 1               5                  10                  15      
Pro Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Ser Gly Ala Pro Thr Tyr Ala Asp Asp Phe
    50                  55                  60                  
Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Pro Pro His Tyr Tyr Val Asn Ser Phe Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120     


<210> 43 
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 43 
Gln Val His Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Ser Gly Ala Pro Thr Tyr Ala Asp Asp Phe
    50                  55                  60                  
Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Thr Thr Ser Tyr
65                  70                  75                  80  
Leu Gln Ile Ser Thr Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys
                85                  90                  95      
Ala Arg Lys Pro Pro His Tyr Tyr Val Asn Ser Phe Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120     


<210> 44 
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 44 
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
            20                  25                  30          
Gly Met Ser Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Lys Trp Met
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Ser Gly Ala Pro Thr Tyr Ala Asp Asp Phe
    50                  55                  60                  
Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Asn Thr Ala Phe
65                  70                  75                  80  
Leu Gln Ile Ser Ser Leu Gln Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Pro Pro His Tyr Tyr Val Asn Ser Phe Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120     


<210> 45 
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 45 
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Thr Tyr
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Ser Gly Ala Pro Thr Tyr Ala Asp Asp Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Glu Leu Thr Gly Leu Met Ser Asp Asp Thr Ala Val Tyr Phe Cys
                85                  90                  95      
Ala Arg Lys Pro Pro His Tyr Tyr Val Asn Ser Phe Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120     


<210> 46 
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 46 
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Ser Gly Ala Pro Thr Tyr Ala Asp Asp Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Arg Asp Thr Pro Thr Ser Ala Val Tyr
65                  70                  75                  80  
Leu Asp Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Pro Pro His Tyr Tyr Val Asn Ser Phe Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120     


<210> 47 
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 47 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Ser Gly Ala Pro Thr Tyr Ala Asp Asp Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Pro Pro His Tyr Tyr Val Asn Ser Phe Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120     


<210> 48 
<211> 107
<212> PRT
<213> Mus musculus

<400> 48 
Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly
 1               5                  10                  15      
Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile
        35                  40                  45              
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro
65                  70                  75                  80  
Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 49 
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 49 
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45              
His Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 50 
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 50 
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys
 1               5                  10                  15      
Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala
65                  70                  75                  80  
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Tyr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 51 
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 51 
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 52 
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 52 
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Tyr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 53 
<211> 118
<212> PRT
<213> Mus musculus

<400> 53 
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Gly Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Tyr Leu Arg Ser Gly Asn Asn Tyr Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Gly Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                85                  90                  95      
Ala Ile Tyr Gly Asn Tyr Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Thr Leu Thr Val Ser Ser
        115             


<210> 54 
<211> 107
<212> PRT
<213> Mus musculus

<400> 54 
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15      
Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Ser
            20                  25                  30          
Leu Asn Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile
        35                  40                  45              
Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly
    50                  55                  60                  
Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser
65                  70                  75                  80  
Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Phe
                85                  90                  95      
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 55 
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 55 
Thr Tyr Gly Met Ser
 1               5  


<210> 56 
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 56 
Trp Ile Asn Thr Tyr Ser Gly Ala Pro Thr Tyr Ala Asp Asp Phe Lys
 1               5                  10                  15      
Gly
    


<210> 57 
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 57 
Lys Pro Pro His Tyr Tyr Val Asn Ser Phe Asp Tyr
 1               5                  10          


<210> 58 
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 58 
Arg Ala Ser Gln Ser Ile Ser Asp Tyr Leu His
 1               5                  10      


<210> 59 
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 59 
Gly Tyr Gly Val Thr
 1               5  


<210> 60 
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 60 
Gln Asn Gly His Ser Phe Pro Tyr Thr
 1               5                  


<210> 61 
<211> 327
<212> PRT
<213> Homo sapiens

<400> 61 
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro
            100                 105                 110         
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
    130                 135                 140                 
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe
                165                 170                 175     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Lys
                325         


<210> 62 
<211> 107
<212> PRT
<213> Homo sapiens

<400> 62 
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
 1               5                  10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
            100                 105         


<210> 63 
<211> 416
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 63 
Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln Asn Ala Tyr Leu Pro
 1               5                  10                  15      
Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu Val Pro Val Cys Trp
            20                  25                  30          
Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly Asn Val Val Leu Arg
        35                  40                  45              
Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser Arg Tyr Trp Leu Asn
    50                  55                  60                  
Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr Ile Glu Asn Val Thr
65                  70                  75                  80  
Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile Gln Ile Pro Gly Ile
                85                  90                  95      
Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val Ile Lys Pro Ala Lys
            100                 105                 110         
Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe Thr Ala Ala Phe Pro
        115                 120                 125             
Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala Glu Thr Gln Thr Leu
    130                 135                 140                 
Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile Ser Thr Leu Ala Asn
145                 150                 155                 160 
Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu Arg Asp Ser Gly Ala
                165                 170                 175     
Thr Ile Arg Ile Glu Gly Arg Met Asp Pro Lys Ser Cys Asp Lys Thr
            180                 185                 190         
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
        195                 200                 205             
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
    210                 215                 220                 
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
225                 230                 235                 240 
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
                245                 250                 255     
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
            260                 265                 270         
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
        275                 280                 285             
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
    290                 295                 300                 
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
305                 310                 315                 320 
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
                325                 330                 335     
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
            340                 345                 350         
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
        355                 360                 365             
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
    370                 375                 380                 
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
385                 390                 395                 400 
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                405                 410                 415     


<210> 64 
<211> 416
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 64 
Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln Asn Ala Tyr Leu Pro
 1               5                  10                  15      
Cys Phe Tyr Thr Leu Pro Thr Ser Gly Thr Leu Val Pro Val Cys Trp
            20                  25                  30          
Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly Asn Val Val Leu Arg
        35                  40                  45              
Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser Arg Tyr Trp Leu Asn
    50                  55                  60                  
Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr Ile Glu Asn Val Thr
65                  70                  75                  80  
Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile Gln Ile Pro Gly Ile
                85                  90                  95      
Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val Ile Lys Pro Ala Lys
            100                 105                 110         
Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe Thr Ala Ala Phe Pro
        115                 120                 125             
Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala Glu Thr Gln Thr Leu
    130                 135                 140                 
Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile Ser Thr Leu Ala Asn
145                 150                 155                 160 
Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu Arg Asp Ser Gly Ala
                165                 170                 175     
Thr Ile Arg Ile Glu Gly Arg Met Asp Pro Lys Ser Cys Asp Lys Thr
            180                 185                 190         
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
        195                 200                 205             
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
    210                 215                 220                 
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
225                 230                 235                 240 
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
                245                 250                 255     
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
            260                 265                 270         
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
        275                 280                 285             
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
    290                 295                 300                 
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
305                 310                 315                 320 
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
                325                 330                 335     
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
            340                 345                 350         
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
        355                 360                 365             
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
    370                 375                 380                 
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
385                 390                 395                 400 
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                405                 410                 415     


<210> 65 
<211> 416
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 65 
Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln Asn Ala Tyr Leu Pro
 1               5                  10                  15      
Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu Val Pro Val Cys Trp
            20                  25                  30          
Gly Lys Gly Ala Cys Pro Trp Ser Gln Cys Gly Asn Val Val Leu Arg
        35                  40                  45              
Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser Arg Tyr Trp Leu Asn
    50                  55                  60                  
Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr Ile Glu Asn Val Thr
65                  70                  75                  80  
Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile Gln Ile Pro Gly Ile
                85                  90                  95      
Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val Ile Lys Pro Ala Lys
            100                 105                 110         
Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe Thr Ala Ala Phe Pro
        115                 120                 125             
Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala Glu Thr Gln Thr Leu
    130                 135                 140                 
Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile Ser Thr Leu Ala Asn
145                 150                 155                 160 
Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu Arg Asp Ser Gly Ala
                165                 170                 175     
Thr Ile Arg Ile Glu Gly Arg Met Asp Pro Lys Ser Cys Asp Lys Thr
            180                 185                 190         
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
        195                 200                 205             
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
    210                 215                 220                 
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
225                 230                 235                 240 
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
                245                 250                 255     
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
            260                 265                 270         
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
        275                 280                 285             
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
    290                 295                 300                 
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
305                 310                 315                 320 
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
                325                 330                 335     
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
            340                 345                 350         
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
        355                 360                 365             
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
    370                 375                 380                 
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
385                 390                 395                 400 
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                405                 410                 415     


<210> 66 
<211> 416
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 66 
Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln Asn Ala Tyr Leu Pro
 1               5                  10                  15      
Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu Val Pro Val Cys Trp
            20                  25                  30          
Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly Asn Val Val Leu Arg
        35                  40                  45              
Thr Asp Glu Arg Asn Val Thr Tyr Trp Thr Ser Arg Tyr Trp Leu Asn
    50                  55                  60                  
Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr Ile Glu Asn Val Thr
65                  70                  75                  80  
Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile Gln Ile Pro Gly Ile
                85                  90                  95      
Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val Ile Lys Pro Ala Lys
            100                 105                 110         
Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe Thr Ala Ala Phe Pro
        115                 120                 125             
Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala Glu Thr Gln Thr Leu
    130                 135                 140                 
Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile Ser Thr Leu Ala Asn
145                 150                 155                 160 
Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu Arg Asp Ser Gly Ala
                165                 170                 175     
Thr Ile Arg Ile Glu Gly Arg Met Asp Pro Lys Ser Cys Asp Lys Thr
            180                 185                 190         
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
        195                 200                 205             
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
    210                 215                 220                 
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
225                 230                 235                 240 
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
                245                 250                 255     
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
            260                 265                 270         
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
        275                 280                 285             
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
    290                 295                 300                 
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
305                 310                 315                 320 
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
                325                 330                 335     
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
            340                 345                 350         
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
        355                 360                 365             
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
    370                 375                 380                 
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
385                 390                 395                 400 
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                405                 410                 415     


<210> 67 
<211> 416
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 67 
Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln Asn Ala Tyr Leu Pro
 1               5                  10                  15      
Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu Val Pro Val Cys Trp
            20                  25                  30          
Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly Asn Val Val Leu Arg
        35                  40                  45              
Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser Arg Tyr Trp Leu Asn
    50                  55                  60                  
Gly Asp Leu Asn Lys Gly Asp Val Ser Leu Thr Ile Glu Asn Val Thr
65                  70                  75                  80  
Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile Gln Ile Pro Gly Ile
                85                  90                  95      
Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val Ile Lys Pro Ala Lys
            100                 105                 110         
Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe Thr Ala Ala Phe Pro
        115                 120                 125             
Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala Glu Thr Gln Thr Leu
    130                 135                 140                 
Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile Ser Thr Leu Ala Asn
145                 150                 155                 160 
Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu Arg Asp Ser Gly Ala
                165                 170                 175     
Thr Ile Arg Ile Glu Gly Arg Met Asp Pro Lys Ser Cys Asp Lys Thr
            180                 185                 190         
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
        195                 200                 205             
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
    210                 215                 220                 
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
225                 230                 235                 240 
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
                245                 250                 255     
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
            260                 265                 270         
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
        275                 280                 285             
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
    290                 295                 300                 
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
305                 310                 315                 320 
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
                325                 330                 335     
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
            340                 345                 350         
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
        355                 360                 365             
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
    370                 375                 380                 
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
385                 390                 395                 400 
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                405                 410                 415     


<210> 68 
<211> 416
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 68 
Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln Asn Ala Tyr Leu Pro
 1               5                  10                  15      
Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu Val Pro Val Cys Trp
            20                  25                  30          
Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly Asn Val Val Leu Arg
        35                  40                  45              
Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser Arg Tyr Trp Leu Asn
    50                  55                  60                  
Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr Ile Glu Asn Val Thr
65                  70                  75                  80  
Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile Gln Phe Pro Gly Leu
                85                  90                  95      
Met Asn Asp Lys Lys Phe Asn Leu Lys Leu Val Ile Lys Pro Ala Lys
            100                 105                 110         
Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe Thr Ala Ala Phe Pro
        115                 120                 125             
Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala Glu Thr Gln Thr Leu
    130                 135                 140                 
Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile Ser Thr Leu Ala Asn
145                 150                 155                 160 
Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu Arg Asp Ser Gly Ala
                165                 170                 175     
Thr Ile Arg Ile Glu Gly Arg Met Asp Pro Lys Ser Cys Asp Lys Thr
            180                 185                 190         
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
        195                 200                 205             
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
    210                 215                 220                 
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
225                 230                 235                 240 
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
                245                 250                 255     
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
            260                 265                 270         
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
        275                 280                 285             
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
    290                 295                 300                 
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
305                 310                 315                 320 
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
                325                 330                 335     
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
            340                 345                 350         
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
        355                 360                 365             
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
    370                 375                 380                 
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
385                 390                 395                 400 
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                405                 410                 415     


<210> 69 
<211> 346
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 69 
Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln Asn Ala Tyr Leu Pro
 1               5                  10                  15      
Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu Val Pro Val Cys Trp
            20                  25                  30          
Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly Asn Val Val Leu Arg
        35                  40                  45              
Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser Arg Tyr Trp Leu Asn
    50                  55                  60                  
Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr Ile Glu Asn Val Thr
65                  70                  75                  80  
Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile Gln Ile Pro Gly Ile
                85                  90                  95      
Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val Ile Lys Ile Glu Gly
            100                 105                 110         
Arg Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
        115                 120                 125             
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
    130                 135                 140                 
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
145                 150                 155                 160 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
                165                 170                 175     
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
            180                 185                 190         
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
        195                 200                 205             
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
    210                 215                 220                 
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
225                 230                 235                 240 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
                245                 250                 255     
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
            260                 265                 270         
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
        275                 280                 285             
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
    290                 295                 300                 
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
305                 310                 315                 320 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
                325                 330                 335     
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            340                 345     


<210> 70 
<211> 114
<212> PRT
<213> Mus musculus

<400> 70 
Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Thr Pro Gly Thr
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Ile Ala Tyr
65                  70                  75                  80  
Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                85                  90                  95      
Ala Gly Asp Arg Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val
            100                 105                 110         
Ser Ser
        


<210> 71 
<211> 108
<212> PRT
<213> Mus musculus

<400> 71 
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
 1               5                  10                  15      
Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Gly Val Ser Ser Ser
            20                  25                  30          
Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
        35                  40                  45              
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Asn Met Glu
65                  70                  75                  80  
Thr Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Ser Asn Ser Pro
                85                  90                  95      
Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105             


<210> 72 
<211> 124
<212> PRT
<213> Mus musculus

<400> 72 
Asp Val Gln Phe Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly
            20                  25                  30          
Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp
        35                  40                  45              
Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu
    50                  55                  60                  
Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe
65                  70                  75                  80  
Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys
                85                  90                  95      
Gly Arg Asp Gly Pro Tyr Tyr Tyr Gly Ser Ser Tyr Gly Tyr Phe Asp
            100                 105                 110         
Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser
        115                 120                 


<210> 73 
<211> 112
<212> PRT
<213> Mus musculus

<400> 73 
Asp Ile Val Met Thr Gln Ala Glu Ser Ser Val Pro Val Thr Pro Gly
 1               5                  10                  15      
Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser
        35                  40                  45              
Pro Gln Leu Leu Ile His Arg Met Ser Asn Leu Ala Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Met Gly Val Tyr Tyr Cys Met Gln His
                85                  90                  95      
Leu Glu Tyr Pro Cys Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 74 
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 74 
Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser Arg Tyr Trp Leu
 1               5                  10                  15      
Asn Gly Asp Phe Arg Lys Gly Asp Val Ser
            20                  25      


<210> 75 
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 75 
Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser Arg Tyr Trp Leu Asn Gly
 1               5                  10                  15      
Asp Phe Arg Lys
            20  


<210> 76 
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 76 
Arg Thr Asp Glu Arg Asp Val Asn Tyr
 1               5                  


<210> 77 
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 77 
Asp Glu Arg Asp Val Asn
 1               5      


<210> 78 
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 78 
Asn Gly Asp Phe Arg Lys Gly Asp Val Ser
 1               5                  10  


<210> 79 
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 79 
Asp Phe Arg Lys
 1              


<210> 80 
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 80 
Met Ile Trp Gly Asp Gly Asn Thr Asp Tyr Asn Ser Gly Leu Lys Ser
 1               5                  10                  15      


<210> 81 
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 81 
Ser Tyr Tyr Tyr Gly Pro Pro Asp Tyr
 1               5                  


<210> 82 
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 82 
Ser Gly Tyr Tyr Trp Asn
 1               5      


<210> 83 
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 83 
Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Asn
 1               5                  10                  15      


<210> 84 
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 84 
Asp Gly Pro Tyr Tyr Tyr Gly Ser Ser Tyr Gly Tyr Phe Asp Val
 1               5                  10                  15  


<210> 85 
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 85 
Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr
 1               5                  10                  15      


<210> 86 
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 86 
Arg Met Ser Asn Leu Ala Ser
 1               5          


<210> 87 
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 87 
Met Gln His Leu Glu Tyr Pro Cys Thr
 1               5                  


<210> 88 
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 88 
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Ser Gln Lys Asn Tyr Leu
 1               5                  10                  15      
Ala
    


<210> 89 
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 89 
Phe Ala Ser Thr Arg Glu Ser
 1               5          


<210> 90 
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 90 
Asp Tyr Tyr Ile Asn
 1               5  


<210> 91 
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 91 
Asn Tyr Gly Met Ser
 1               5  


<210> 92 
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 92 
Asp Arg Phe Asp Tyr
 1               5  


<210> 93 
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 93 
Ser Ala Ser Ser Gly Val Ser Ser Ser Tyr Leu Tyr
 1               5                  10          


<210> 94 
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 94 
Ser Thr Ser Asn Leu Ala Ser
 1               5          


<210> 95 
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 95 
His Gln Trp Ser Asn Ser Pro Tyr Thr
 1               5                  


<210> 96 
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 96 
Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys
 1               5                  10  


<210> 97 
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 97 
Asn His Gly Met Ser
 1               5  


<210> 98 
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 98 
Thr Ile Ser Ser Gly Gly Ser Asn Thr Tyr
 1               5                  10  

<210> 99 
<211> 203
<212> PRT
<213> Homo sapiens

<400> 99 
Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu
 1               5                  10                  15      
Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln
            20                  25                  30          
Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu
        35                  40                  45              
Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly
    50                  55                  60                  
Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser
65                  70                  75                  80  
Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr
                85                  90                  95      
Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile
            100                 105                 110         
Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val
        115                 120                 125             
Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe
    130                 135                 140                 
Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Gly Pro
145                 150                 155                 160 
Ala Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln
                165                 170                 175     
Ile Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp
            180                 185                 190         
Leu Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly
        195                 200             


<210> 100 
<211> 194
<212> PRT
<213> Mus musculus

<400> 100 
Met Phe Ser Gly Leu Thr Leu Asn Cys Val Leu Leu Leu Leu Gln Leu
 1               5                  10                  15      
Leu Leu Ala Arg Ser Leu Glu Asp Gly Tyr Lys Val Glu Val Gly Lys
            20                  25                  30          
Asn Ala Tyr Leu Pro Cys Ser Tyr Thr Leu Pro Thr Ser Gly Thr Leu
        35                  40                  45              
Val Pro Met Cys Trp Gly Lys Gly Phe Cys Pro Trp Ser Gln Cys Thr
    50                  55                  60                  
Asn Glu Leu Leu Arg Thr Asp Glu Arg Asn Val Thr Tyr Gln Lys Ser
65                  70                  75                  80  
Ser Arg Tyr Gln Leu Lys Gly Asp Leu Asn Lys Gly Asp Val Ser Leu
                85                  90                  95      
Ile Ile Lys Asn Val Thr Leu Asp Asp His Gly Thr Tyr Cys Cys Arg
            100                 105                 110         
Ile Gln Phe Pro Gly Leu Met Asn Asp Lys Lys Leu Glu Leu Lys Leu
        115                 120                 125             
Asp Ile Lys Ala Ala Lys Val Thr Pro Ala Gln Thr Ala His Gly Asp
    130                 135                 140                 
Ser Thr Thr Ala Ser Pro Arg Thr Leu Thr Thr Glu Arg Asn Gly Gly
145                 150                 155                 160 
Ser Glu Thr Gln Thr Leu Val Thr Leu His Asn Asn Asn Gly Thr Lys
                165                 170                 175     
Ile Ser Thr Trp Ala Asp Glu Ile Lys Asp Ser Gly Glu Thr Ile Arg
            180                 185                 190         
Thr Ala
        


<210> 101 
<211> 11
<212> PRT
<213> Homo sapiens

<400> 101 
Ala Lys Val Thr Pro Ala Thr Thr Arg Gln Thr
 1               5                  10      


<210> 102 
<211> 12
<212> PRT
<213> Homo sapiens

<400> 102 
Gly Glu Trp Thr Gly Phe Ala Cys His Leu Tyr Glu
 1               5                  10          

