                         SEQUENCE LISTING

<110>  Agency for Science, Technology and Research
 
<120>  Anti-PD-L1 Antibodies

<130>  RIC/FP7082969

<160>  36    

<170>  PatentIn version 3.3

<210>  1
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Ser Cys Ser Gly Arg Ser Ser Asn Ile Ala Ser His 
            20                  25                  30          


Asp Val Phe Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Ile Val 
        35                  40                  45              


Met Tyr Glu Thr Asn Lys Arg Pro Trp Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Asp Ile Ala Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Trp Asp Ser Gly Leu 
                85                  90                  95      


Thr Gly Met Leu Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  2
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Thr Arg Ile Thr Cys Gly Gly Asp Asn Ile Gly Arg Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Leu Leu Leu Val Tyr 
        35                  40                  45              


Asp Asp Gly Asp Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Thr Val Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Arg Leu Thr Val Leu 
            100                 105 


<210>  3
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  3

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Glu Arg Leu Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Val Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  4
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Ser Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105                 110         


Leu 
    


<210>  5
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  5

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ser Tyr Gly Ser Leu Tyr Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  6
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  6

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ser Tyr Gly Ser Leu Tyr Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  7
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  7

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Gly Gly Asn Ser Leu Tyr Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  8
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  8

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly His Gly Tyr Ser Tyr Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu 
        115     


<210>  9
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  9

Ser Gly Arg Ser Ser Asn Ile Ala Ser His Asp Val Phe 
1               5                   10              


<210>  10
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  10

Glu Thr Asn Lys Arg Pro Trp 
1               5           


<210>  11
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  11

Gly Ala Trp Asp Ser Gly Leu Thr Gly Met Leu 
1               5                   10      


<210>  12
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  12

Gly Gly Asp Asn Ile Gly Arg Lys Ser Val His 
1               5                   10      


<210>  13
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  13

Asp Asp Gly Asp Arg Pro Ser 
1               5           


<210>  14
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  14

Gln Ala Trp Asp Ser Thr Val Val 
1               5               


<210>  15
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  15

Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 
1               5                   10              


<210>  16
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  16

Asp Asn Asn Glu Arg Leu Ser 
1               5           


<210>  17
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  17

Gly Thr Trp Asp Ser Ser Leu Ser Val Val Val 
1               5                   10      


<210>  18
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  18

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  19
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  19

Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  20
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Tyr Val Val 
1               5                   10              


<210>  21
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  21

Ser Tyr Ala Ile Ser 
1               5   


<210>  22
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  22

Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  23
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  23

Gly Gly Ser Tyr Gly Ser Leu Tyr Ala Phe Asp Ile 
1               5                   10          


<210>  24
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  24

Gly Gly Tyr Gly Gly Asn Ser Leu Tyr Ala Phe Asp Ile 
1               5                   10              


<210>  25
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  25

Ser Gly His Gly Tyr Ser Tyr Gly Ala Phe Asp Tyr 
1               5                   10          


<210>  26
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy chain CDR3 consensus

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa = absent or Gly

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa = Gly or Ser

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa = Gly or Tyr

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa = Ser, Gly or His

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa = Tyr or Gly

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa = Gly, Asn or Tyr

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa = Leu or Tyr

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa = Tyr or Gly

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Xaa = Ile or Tyr

<400>  26

Xaa Xaa Xaa Xaa Xaa Xaa Ser Xaa Xaa Ala Phe Asp Xaa 
1               5                   10              


<210>  27
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  27
cagtctgtgt tgacgcagcc tccctcagtg tctgcggccc caggacagag agtctccatc     60

tcctgctctg ggaggagctc caacattgcc agtcatgatg ttttctggta ccagcaactc    120

ccaggaacag cccccaaaat cgtcatgtat gaaactaata aacgtccctg ggggattcct    180

gaccgattct ccggctccaa gtctggcacg tccgccaccc tggacatcgc cggactccag    240

actggggacg aggccgacta ttactgcgga gcatgggata gcggcctgac tggtatgctg    300

ttcggcggag ggaccaaggt gaccgtccta                                     330


<210>  28
<211>  315
<212>  DNA
<213>  Homo sapiens

<400>  28
tcctatgagc tgactcagcc accctcggtg tcagtggccc caggaaagac gaccaggatt     60

acctgtgggg gagacaacat tggacgtaaa agtgtccatt ggtatcagca gaggccaggc    120

caggcccctc tcctcctcgt ctatgatgat ggcgaccggc cctcagggat ccctgaccga    180

ttctctggct ccaactctgg gaacacagcc actctgacca tcagcgggac ccaggctatg    240

gatgaggctg actattactg tcaggcgtgg gacagcaccg tggtattcgg cggagggacc    300

agactgaccg tcctg                                                     315


<210>  29
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  29
cagtctgtcg tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc     60

tcctgctctg gaagtagctc caacattggg aataattatg tatcctggta ccagcagctc    120

ccaggaacag cccccaaact cctcatttat gacaataatg agcgactctc agggattcct    180

gaccgattct ctggttccaa gtctggcacg tcagccaccc tgggcatcag cggactccag    240

actggggacg aggccgatta ttactgcggc acatgggata gtagcctgag tgtcgtggta    300

ttcggcggag ggaccaagct gaccgtccta                                     330


<210>  30
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  30
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc     60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag    120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc    180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc    240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggttct    300

tatgtggtat tcggcggagg gaccaagctg accgtccta                           339


<210>  31
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  31
caggtacagc tgcagcagtc aggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc     60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggaagg atcatcccta tccttggtat agcaaactac    180

gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgag cacagcctac    240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagggggc    300

agctatggtt ctctctatgc ttttgatatc tggggccaag ggacaatggt caccgtctca    360

agc                                                                  363


<210>  32
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  32
caggtacagc tgcagcagtc aggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc     60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggaagg atcatcccta tccttggtat agcaaactac    180

gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgag cacagcctac    240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagggggc    300

agctatggtt ctctctatgc ttttgatatc tggggccaag ggaccagggt caccgtctca    360

agc                                                                  363


<210>  33
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  33
caggtacagc tgcagcagtc aggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc     60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggaagg atcatcccta tccttggtat agcaaactac    180

gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgag cacagcctac    240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagggggggc    300

tacggtggta actccttgta tgcttttgat atctggggcc aagggacaat ggtcaccgtc    360

tcctca                                                               366


<210>  34
<211>  348
<212>  DNA
<213>  Homo sapiens

<400>  34
gaagtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc     60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggaagg atcatcccta tccttggtat agcaaactac    180

gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgag cacagcctac    240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gaggtcaggg    300

catggataca gctatggagc ttttgactac tggggccagg gcaccctg                 348


<210>  35
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  35

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly His Gly Tyr Ser Tyr Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  36
<211>  363
<212>  DNA
<213>  Homo sapiens

<400>  36
caggtgcagc tggtgcaatc tggggctgag gtgaagaagc ctgggtcctc agtgaaggtc     60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggaagg atcatcccta tccttggtat agcaaactac    180

gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgag cacagcctac    240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gaggtcaggg    300

catggataca gctatggagc ttttgactac tggggccagg gcaccctggt caccgtctca    360

agc                                                                  363

