
                                SEQUENCE LISTING

<110> Celgene Corporation

<120> METHODS OF TREATING HEMATOLOGICAL DISORDERS, SOLID TUMORS,
 OR INFECTIOUS DISEASES USING NATURAL KILLER CELLS

<130> 12827-786-228

<140> PCT/US2015/068069   
<141> 2015-12-30  

<150> US 62/098,547          
<151> 2014-12-31  

<150> US 62/139,952          
<151> 2015-03-30  

<160> 42

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1912
<212> DNA
<213> Homo sapiens

<220> 
<223> Exemplary nucleic acid sequence encoding human CXCR4 isoform a,
GenBank Accession No. NM_001008540.1

<400> 1
ttttttttct tccctctagt gggcggggca gaggagttag ccaagatgtg actttgaaac 60
cctcagcgtc tcagtgccct tttgttctaa acaaagaatt ttgtaattgg ttctaccaaa 120
gaaggatata atgaagtcac tatgggaaaa gatggggagg agagttgtag gattctacat 180
taattctctt gtgcccttag cccactactt cagaatttcc tgaagaaagc aagcctgaat 240
tggtttttta aattgcttta aaaatttttt ttaactgggt taatgcttgc tgaattggaa 300
gtgaatgtcc attcctttgc ctcttttgca gatatacact tcagataact acaccgagga 360
aatgggctca ggggactatg actccatgaa ggaaccctgt ttccgtgaag aaaatgctaa 420
tttcaataaa atcttcctgc ccaccatcta ctccatcatc ttcttaactg gcattgtggg 480
caatggattg gtcatcctgg tcatgggtta ccagaagaaa ctgagaagca tgacggacaa 540
gtacaggctg cacctgtcag tggccgacct cctctttgtc atcacgcttc ccttctgggc 600
agttgatgcc gtggcaaact ggtactttgg gaacttccta tgcaaggcag tccatgtcat 660
ctacacagtc aacctctaca gcagtgtcct catcctggcc ttcatcagtc tggaccgcta 720
cctggccatc gtccacgcca ccaacagtca gaggccaagg aagctgttgg ctgaaaaggt 780
ggtctatgtt ggcgtctgga tccctgccct cctgctgact attcccgact tcatctttgc 840
caacgtcagt gaggcagatg acagatatat ctgtgaccgc ttctacccca atgacttgtg 900
ggtggttgtg ttccagtttc agcacatcat ggttggcctt atcctgcctg gtattgtcat 960
cctgtcctgc tattgcatta tcatctccaa gctgtcacac tccaagggcc accagaagcg 1020
caaggccctc aagaccacag tcatcctcat cctggctttc ttcgcctgtt ggctgcctta 1080
ctacattggg atcagcatcg actccttcat cctcctggaa atcatcaagc aagggtgtga 1140
gtttgagaac actgtgcaca agtggatttc catcaccgag gccctagctt tcttccactg 1200
ttgtctgaac cccatcctct atgctttcct tggagccaaa tttaaaacct ctgcccagca 1260
cgcactcacc tctgtgagca gagggtccag cctcaagatc ctctccaaag gaaagcgagg 1320
tggacattca tctgtttcca ctgagtctga gtcttcaagt tttcactcca gctaacacag 1380
atgtaaaaga ctttttttta tacgataaat aacttttttt taagttacac atttttcaga 1440
tataaaagac tgaccaatat tgtacagttt ttattgcttg ttggattttt gtcttgtgtt 1500
tctttagttt ttgtgaagtt taattgactt atttatataa attttttttg tttcatattg 1560
atgtgtgtct aggcaggacc tgtggccaag ttcttagttg ctgtatgtct cgtggtagga 1620
ctgtagaaaa gggaactgaa cattccagag cgtgtagtga atcacgtaaa gctagaaatg 1680
atccccagct gtttatgcat agataatctc tccattcccg tggaacgttt ttcctgttct 1740
taagacgtga ttttgctgta gaagatggca cttataacca aagcccaaag tggtatagaa 1800
atgctggttt ttcagttttc aggagtgggt tgatttcagc acctacagtg tacagtcttg 1860
tattaagttg ttaataaaag tacatgttaa acttaaaaaa aaaaaaaaaa aa         1912

<210> 2
<211> 1691
<212> DNA
<213> Homo sapiens

<220> 
<223> Exemplary nucleic acid sequence encoding human CXCR4 isoform b,
GenBank Accession No. NM_003467.2

<400> 2
aacttcagtt tgttggctgc ggcagcaggt agcaaagtga cgccgagggc ctgagtgctc 60
cagtagccac cgcatctgga gaaccagcgg ttaccatgga ggggatcagt atatacactt 120
cagataacta caccgaggaa atgggctcag gggactatga ctccatgaag gaaccctgtt 180
tccgtgaaga aaatgctaat ttcaataaaa tcttcctgcc caccatctac tccatcatct 240
tcttaactgg cattgtgggc aatggattgg tcatcctggt catgggttac cagaagaaac 300
tgagaagcat gacggacaag tacaggctgc acctgtcagt ggccgacctc ctctttgtca 360
tcacgcttcc cttctgggca gttgatgccg tggcaaactg gtactttggg aacttcctat 420
gcaaggcagt ccatgtcatc tacacagtca acctctacag cagtgtcctc atcctggcct 480
tcatcagtct ggaccgctac ctggccatcg tccacgccac caacagtcag aggccaagga 540
agctgttggc tgaaaaggtg gtctatgttg gcgtctggat ccctgccctc ctgctgacta 600
ttcccgactt catctttgcc aacgtcagtg aggcagatga cagatatatc tgtgaccgct 660
tctaccccaa tgacttgtgg gtggttgtgt tccagtttca gcacatcatg gttggcctta 720
tcctgcctgg tattgtcatc ctgtcctgct attgcattat catctccaag ctgtcacact 780
ccaagggcca ccagaagcgc aaggccctca agaccacagt catcctcatc ctggctttct 840
tcgcctgttg gctgccttac tacattggga tcagcatcga ctccttcatc ctcctggaaa 900
tcatcaagca agggtgtgag tttgagaaca ctgtgcacaa gtggatttcc atcaccgagg 960
ccctagcttt cttccactgt tgtctgaacc ccatcctcta tgctttcctt ggagccaaat 1020
ttaaaacctc tgcccagcac gcactcacct ctgtgagcag agggtccagc ctcaagatcc 1080
tctccaaagg aaagcgaggt ggacattcat ctgtttccac tgagtctgag tcttcaagtt 1140
ttcactccag ctaacacaga tgtaaaagac ttttttttat acgataaata actttttttt 1200
aagttacaca tttttcagat ataaaagact gaccaatatt gtacagtttt tattgcttgt 1260
tggatttttg tcttgtgttt ctttagtttt tgtgaagttt aattgactta tttatataaa 1320
ttttttttgt ttcatattga tgtgtgtcta ggcaggacct gtggccaagt tcttagttgc 1380
tgtatgtctc gtggtaggac tgtagaaaag ggaactgaac attccagagc gtgtagtgaa 1440
tcacgtaaag ctagaaatga tccccagctg tttatgcata gataatctct ccattcccgt 1500
ggaacgtttt tcctgttctt aagacgtgat tttgctgtag aagatggcac ttataaccaa 1560
agcccaaagt ggtatagaaa tgctggtttt tcagttttca ggagtgggtt gatttcagca 1620
cctacagtgt acagtcttgt attaagttgt taataaaagt acatgttaaa cttaaaaaaa 1680
aaaaaaaaaa a                                                      1691

<210> 3
<211> 356
<212> PRT
<213> Homo sapiens

<220> 
<223> Exemplary amino acid sequence of human CXCR4 isoform a,
GenBank Accession No. NP_001008540.1

<400> 3
Met Ser Ile Pro Leu Pro Leu Leu Gln Ile Tyr Thr Ser Asp Asn Tyr
 1               5                  10                  15      
Thr Glu Glu Met Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys
            20                  25                  30          
Phe Arg Glu Glu Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile
        35                  40                  45              
Tyr Ser Ile Ile Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile
    50                  55                  60                  
Leu Val Met Gly Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr
65                  70                  75                  80  
Arg Leu His Leu Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro
                85                  90                  95      
Phe Trp Ala Val Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu
            100                 105                 110         
Cys Lys Ala Val His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val
        115                 120                 125             
Leu Ile Leu Ala Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His
    130                 135                 140                 
Ala Thr Asn Ser Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val
145                 150                 155                 160 
Tyr Val Gly Val Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe
                165                 170                 175     
Ile Phe Ala Asn Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg
            180                 185                 190         
Phe Tyr Pro Asn Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile
        195                 200                 205             
Met Val Gly Leu Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys
    210                 215                 220                 
Ile Ile Ile Ser Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys
225                 230                 235                 240 
Ala Leu Lys Thr Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp
                245                 250                 255     
Leu Pro Tyr Tyr Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu
            260                 265                 270         
Ile Ile Lys Gln Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile
        275                 280                 285             
Ser Ile Thr Glu Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile
    290                 295                 300                 
Leu Tyr Ala Phe Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala
305                 310                 315                 320 
Leu Thr Ser Val Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly
                325                 330                 335     
Lys Arg Gly Gly His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser
            340                 345                 350         
Phe His Ser Ser
        355     


<210> 4
<211> 352
<212> PRT
<213> Homo sapiens

<220> 
<223> Exemplary amino acid sequence of human CXCR4 isoform b,
GenBank Accession No. NP_003458.1

<400> 4
Met Glu Gly Ile Ser Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met
 1               5                  10                  15      
Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu Glu
            20                  25                  30          
Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile Tyr Ser Ile Ile
        35                  40                  45              
Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met Gly
    50                  55                  60                  
Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His Leu
65                  70                  75                  80  
Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp Ala Val
                85                  90                  95      
Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala Val
            100                 105                 110         
His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu Ala
        115                 120                 125             
Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn Ser
    130                 135                 140                 
Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val Tyr Val Gly Val
145                 150                 155                 160 
Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala Asn
                165                 170                 175     
Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro Asn
            180                 185                 190         
Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile Met Val Gly Leu
        195                 200                 205             
Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile Ser
    210                 215                 220                 
Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys Thr
225                 230                 235                 240 
Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr Tyr
                245                 250                 255     
Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys Gln
            260                 265                 270         
Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile Ser Ile Thr Glu
        275                 280                 285             
Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala Phe
    290                 295                 300                 
Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr Ser Val
305                 310                 315                 320 
Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly Gly
                325                 330                 335     
His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser Ser
            340                 345                 350         


<210> 5
<211> 2157
<212> DNA
<213> Homo sapiens

<220> 
<223> Exemplary nucleic acid sequence encoding human CCR7 isoform b,
GenBank Accession No. NM_001301714.1

<400> 5
cacttcctcc ccagacaggg gtagtgcgag gccgggcaca gccttcctgt gtggttttac 60
cgcccagaga gcgtcatgga cctgggtatg cctgtgtcaa gatgaggtca cggacgatta 120
catcggagac aacaccacag tggactacac tttgttcgag tctttgtgct ccaagaagga 180
cgtgcggaac tttaaagcct ggttcctccc tatcatgtac tccatcattt gtttcgtggg 240
cctactgggc aatgggctgg tcgtgttgac ctatatctat ttcaagaggc tcaagaccat 300
gaccgatacc tacctgctca acctggcggt ggcagacatc ctcttcctcc tgacccttcc 360
cttctgggcc tacagcgcgg ccaagtcctg ggtcttcggt gtccactttt gcaagctcat 420
ctttgccatc tacaagatga gcttcttcag tggcatgctc ctacttcttt gcatcagcat 480
tgaccgctac gtggccatcg tccaggctgt ctcagctcac cgccaccgtg cccgcgtcct 540
tctcatcagc aagctgtcct gtgtgggcat ctggatacta gccacagtgc tctccatccc 600
agagctcctg tacagtgacc tccagaggag cagcagtgag caagcgatgc gatgctctct 660
catcacagag catgtggagg cctttatcac catccaggtg gcccagatgg tgatcggctt 720
tctggtcccc ctgctggcca tgagcttctg ttaccttgtc atcatccgca ccctgctcca 780
ggcacgcaac tttgagcgca acaaggccat caaggtgatc atcgctgtgg tcgtggtctt 840
catagtcttc cagctgccct acaatggggt ggtcctggcc cagacggtgg ccaacttcaa 900
catcaccagt agcacctgtg agctcagtaa gcaactcaac atcgcctacg acgtcaccta 960
cagcctggcc tgcgtccgct gctgcgtcaa ccctttcttg tacgccttca tcggcgtcaa 1020
gttccgcaac gatctcttca agctcttcaa ggacctgggc tgcctcagcc aggagcagct 1080
ccggcagtgg tcttcctgtc ggcacatccg gcgctcctcc atgagtgtgg aggccgagac 1140
caccaccacc ttctccccat aggcgactct tctgcctgga ctagagggac ctctcccagg 1200
gtccctgggg tggggatagg gagcagatgc aatgactcag gacatccccc cgccaaaagc 1260
tgctcaggga aaagcagctc tcccctcaga gtgcaagccc ctgctccaga agatagcttc 1320
accccaatcc cagctacctc aaccaatgcc aaaaaaagac agggctgata agctaacacc 1380
agacagacaa cactgggaaa cagaggctat tgtcccctaa accaaaaact gaaagtgaaa 1440
gtccagaaac tgttcccacc tgctggagtg aaggggccaa ggagggtgag tgcaaggggc 1500
gtgggagtgg cctgaagagt cctctgaatg aaccttctgg cctcccacag actcaaatgc 1560
tcagaccagc tcttccgaaa accaggcctt atctccaaga ccagagatag tggggagact 1620
tcttggcttg gtgaggaaaa gcggacatca gctggtcaaa caaactctct gaacccctcc 1680
ctccatcgtt ttcttcactg tcctccaagc cagcgggaat ggcagctgcc acgccgccct 1740
aaaagcacac tcatcccctc acttgccgcg tcgccctccc aggctctcaa caggggagag 1800
tgtggtgttt cctgcaggcc aggccagctg cctccgcgtg atcaaagcca cactctgggc 1860
tccagagtgg ggatgacatg cactcagctc ttggctccac tgggatggga ggagaggaca 1920
agggaaatgt caggggcggg gagggtgaca gtggccgccc aaggcccacg agcttgttct 1980
ttgttctttg tcacagggac tgaaaacctc tcctcatgtt ctgctttcga ttcgttaaga 2040
gagcaacatt ttacccacac acagataaag ttttcccttg aggaaacaac agctttaaaa 2100
gaaaaagaaa aaaaaagtct ttggtaaatg gcaaaaaaaa aaaaaaaaaa aaaaaaa    2157

<210> 6
<211> 2457
<212> DNA
<213> Homo sapiens

<220> 
<223> Exemplary nucleic acid sequence encoding human CCR7 isoform c,
GenBank Accession No. NM_001301716.1

<400> 6
ctctagatga gtcagtggag ggcgggtgga gcgttgaacc gtgaagagtg tggttgggcg 60
taaacgtgga cttaaactca ggagctaagg ggtaattcag tgaaaaaggg gaatgagcgg 120
tggggagctc tgttgcaaca gggtccaatc gcagcaggac tacaaatgcc cgagcgcagg 180
ctgggaacga ggggacagcg gctgcctgtc cccagaatag aaaatgcagc taggaagccc 240
tctttgagtg gacagcggag gactggactg ccaggccaag catcaggggc ttcatcctca 300
gggccggtta gagcccctga ggatttagga ggaagggaaa ccaatgaaaa gcgtgctggt 360
ggtggctctc cttgtcattt tccaggtatg cctgtgtcaa gatgaggtca cggacgatta 420
catcggagac aacaccacag tggactacac tttgttcgag tctttgtgct ccaagaagga 480
cgtgcggaac tttaaagcct ggttcctccc tatcatgtac tccatcattt gtttcgtggg 540
cctactgggc aatgggctgg tcgtgttgac ctatatctat ttcaagaggc tcaagaccat 600
gaccgatacc tacctgctca acctggcggt ggcagacatc ctcttcctcc tgacccttcc 660
cttctgggcc tacagcgcgg ccaagtcctg ggtcttcggt gtccactttt gcaagctcat 720
ctttgccatc tacaagatga gcttcttcag tggcatgctc ctacttcttt gcatcagcat 780
tgaccgctac gtggccatcg tccaggctgt ctcagctcac cgccaccgtg cccgcgtcct 840
tctcatcagc aagctgtcct gtgtgggcat ctggatacta gccacagtgc tctccatccc 900
agagctcctg tacagtgacc tccagaggag cagcagtgag caagcgatgc gatgctctct 960
catcacagag catgtggagg cctttatcac catccaggtg gcccagatgg tgatcggctt 1020
tctggtcccc ctgctggcca tgagcttctg ttaccttgtc atcatccgca ccctgctcca 1080
ggcacgcaac tttgagcgca acaaggccat caaggtgatc atcgctgtgg tcgtggtctt 1140
catagtcttc cagctgccct acaatggggt ggtcctggcc cagacggtgg ccaacttcaa 1200
catcaccagt agcacctgtg agctcagtaa gcaactcaac atcgcctacg acgtcaccta 1260
cagcctggcc tgcgtccgct gctgcgtcaa ccctttcttg tacgccttca tcggcgtcaa 1320
gttccgcaac gatctcttca agctcttcaa ggacctgggc tgcctcagcc aggagcagct 1380
ccggcagtgg tcttcctgtc ggcacatccg gcgctcctcc atgagtgtgg aggccgagac 1440
caccaccacc ttctccccat aggcgactct tctgcctgga ctagagggac ctctcccagg 1500
gtccctgggg tggggatagg gagcagatgc aatgactcag gacatccccc cgccaaaagc 1560
tgctcaggga aaagcagctc tcccctcaga gtgcaagccc ctgctccaga agatagcttc 1620
accccaatcc cagctacctc aaccaatgcc aaaaaaagac agggctgata agctaacacc 1680
agacagacaa cactgggaaa cagaggctat tgtcccctaa accaaaaact gaaagtgaaa 1740
gtccagaaac tgttcccacc tgctggagtg aaggggccaa ggagggtgag tgcaaggggc 1800
gtgggagtgg cctgaagagt cctctgaatg aaccttctgg cctcccacag actcaaatgc 1860
tcagaccagc tcttccgaaa accaggcctt atctccaaga ccagagatag tggggagact 1920
tcttggcttg gtgaggaaaa gcggacatca gctggtcaaa caaactctct gaacccctcc 1980
ctccatcgtt ttcttcactg tcctccaagc cagcgggaat ggcagctgcc acgccgccct 2040
aaaagcacac tcatcccctc acttgccgcg tcgccctccc aggctctcaa caggggagag 2100
tgtggtgttt cctgcaggcc aggccagctg cctccgcgtg atcaaagcca cactctgggc 2160
tccagagtgg ggatgacatg cactcagctc ttggctccac tgggatggga ggagaggaca 2220
agggaaatgt caggggcggg gagggtgaca gtggccgccc aaggcccacg agcttgttct 2280
ttgttctttg tcacagggac tgaaaacctc tcctcatgtt ctgctttcga ttcgttaaga 2340
gagcaacatt ttacccacac acagataaag ttttcccttg aggaaacaac agctttaaaa 2400
gaaaaagaaa aaaaaagtct ttggtaaatg gcaaaaaaaa aaaaaaaaaa aaaaaaa    2457

<210> 7
<211> 2213
<212> DNA
<213> Homo sapiens

<220> 
<223> Exemplary nucleic acid sequence encoding human CCR7 isoform c,
GenBank Accession No. NM_001301717.1

<400> 7
ctctagatga gtcagtggag ggcgggtgga gcgttgaacc gtgaagagtg tggttgggcg 60
taaacgtgga cttaaactca ggagctaagg gggaaaccaa tgaaaagcgt gctggtggtg 120
gctctccttg tcattttcca ggtatgcctg tgtcaagatg aggtcacgga cgattacatc 180
ggagacaaca ccacagtgga ctacactttg ttcgagtctt tgtgctccaa gaaggacgtg 240
cggaacttta aagcctggtt cctccctatc atgtactcca tcatttgttt cgtgggccta 300
ctgggcaatg ggctggtcgt gttgacctat atctatttca agaggctcaa gaccatgacc 360
gatacctacc tgctcaacct ggcggtggca gacatcctct tcctcctgac ccttcccttc 420
tgggcctaca gcgcggccaa gtcctgggtc ttcggtgtcc acttttgcaa gctcatcttt 480
gccatctaca agatgagctt cttcagtggc atgctcctac ttctttgcat cagcattgac 540
cgctacgtgg ccatcgtcca ggctgtctca gctcaccgcc accgtgcccg cgtccttctc 600
atcagcaagc tgtcctgtgt gggcatctgg atactagcca cagtgctctc catcccagag 660
ctcctgtaca gtgacctcca gaggagcagc agtgagcaag cgatgcgatg ctctctcatc 720
acagagcatg tggaggcctt tatcaccatc caggtggccc agatggtgat cggctttctg 780
gtccccctgc tggccatgag cttctgttac cttgtcatca tccgcaccct gctccaggca 840
cgcaactttg agcgcaacaa ggccatcaag gtgatcatcg ctgtggtcgt ggtcttcata 900
gtcttccagc tgccctacaa tggggtggtc ctggcccaga cggtggccaa cttcaacatc 960
accagtagca cctgtgagct cagtaagcaa ctcaacatcg cctacgacgt cacctacagc 1020
ctggcctgcg tccgctgctg cgtcaaccct ttcttgtacg ccttcatcgg cgtcaagttc 1080
cgcaacgatc tcttcaagct cttcaaggac ctgggctgcc tcagccagga gcagctccgg 1140
cagtggtctt cctgtcggca catccggcgc tcctccatga gtgtggaggc cgagaccacc 1200
accaccttct ccccataggc gactcttctg cctggactag agggacctct cccagggtcc 1260
ctggggtggg gatagggagc agatgcaatg actcaggaca tccccccgcc aaaagctgct 1320
cagggaaaag cagctctccc ctcagagtgc aagcccctgc tccagaagat agcttcaccc 1380
caatcccagc tacctcaacc aatgccaaaa aaagacaggg ctgataagct aacaccagac 1440
agacaacact gggaaacaga ggctattgtc ccctaaacca aaaactgaaa gtgaaagtcc 1500
agaaactgtt cccacctgct ggagtgaagg ggccaaggag ggtgagtgca aggggcgtgg 1560
gagtggcctg aagagtcctc tgaatgaacc ttctggcctc ccacagactc aaatgctcag 1620
accagctctt ccgaaaacca ggccttatct ccaagaccag agatagtggg gagacttctt 1680
ggcttggtga ggaaaagcgg acatcagctg gtcaaacaaa ctctctgaac ccctccctcc 1740
atcgttttct tcactgtcct ccaagccagc gggaatggca gctgccacgc cgccctaaaa 1800
gcacactcat cccctcactt gccgcgtcgc cctcccaggc tctcaacagg ggagagtgtg 1860
gtgtttcctg caggccaggc cagctgcctc cgcgtgatca aagccacact ctgggctcca 1920
gagtggggat gacatgcact cagctcttgg ctccactggg atgggaggag aggacaaggg 1980
aaatgtcagg ggcggggagg gtgacagtgg ccgcccaagg cccacgagct tgttctttgt 2040
tctttgtcac agggactgaa aacctctcct catgttctgc tttcgattcg ttaagagagc 2100
aacattttac ccacacacag ataaagtttt cccttgagga aacaacagct ttaaaagaaa 2160
aagaaaaaaa aagtctttgg taaatggcaa aaaaaaaaaa aaaaaaaaaa aaa        2213

<210> 8
<211> 2303
<212> DNA
<213> Homo sapiens

<220> 
<223> Exemplary nucleic acid sequence encoding human CCR7 isoform c,
GenBank Accession No. NM_001301718.1

<400> 8
aggagaaggt gccttaaaca ggttcccacg catttcctgg cgctattgag cttggagctg 60
ccaagggcct gccttcactt gtggcatcgc agttactgac tctccagtgg gccaggccct 120
acctagctgg gacctgaggg tcaggatacg ggaagagggc tactgccgcc ctgacttgta 180
gggaaaccaa tgaaaagcgt gctggtggtg gctctccttg tcattttcca ggtatgcctg 240
tgtcaagatg aggtcacgga cgattacatc ggagacaaca ccacagtgga ctacactttg 300
ttcgagtctt tgtgctccaa gaaggacgtg cggaacttta aagcctggtt cctccctatc 360
atgtactcca tcatttgttt cgtgggccta ctgggcaatg ggctggtcgt gttgacctat 420
atctatttca agaggctcaa gaccatgacc gatacctacc tgctcaacct ggcggtggca 480
gacatcctct tcctcctgac ccttcccttc tgggcctaca gcgcggccaa gtcctgggtc 540
ttcggtgtcc acttttgcaa gctcatcttt gccatctaca agatgagctt cttcagtggc 600
atgctcctac ttctttgcat cagcattgac cgctacgtgg ccatcgtcca ggctgtctca 660
gctcaccgcc accgtgcccg cgtccttctc atcagcaagc tgtcctgtgt gggcatctgg 720
atactagcca cagtgctctc catcccagag ctcctgtaca gtgacctcca gaggagcagc 780
agtgagcaag cgatgcgatg ctctctcatc acagagcatg tggaggcctt tatcaccatc 840
caggtggccc agatggtgat cggctttctg gtccccctgc tggccatgag cttctgttac 900
cttgtcatca tccgcaccct gctccaggca cgcaactttg agcgcaacaa ggccatcaag 960
gtgatcatcg ctgtggtcgt ggtcttcata gtcttccagc tgccctacaa tggggtggtc 1020
ctggcccaga cggtggccaa cttcaacatc accagtagca cctgtgagct cagtaagcaa 1080
ctcaacatcg cctacgacgt cacctacagc ctggcctgcg tccgctgctg cgtcaaccct 1140
ttcttgtacg ccttcatcgg cgtcaagttc cgcaacgatc tcttcaagct cttcaaggac 1200
ctgggctgcc tcagccagga gcagctccgg cagtggtctt cctgtcggca catccggcgc 1260
tcctccatga gtgtggaggc cgagaccacc accaccttct ccccataggc gactcttctg 1320
cctggactag agggacctct cccagggtcc ctggggtggg gatagggagc agatgcaatg 1380
actcaggaca tccccccgcc aaaagctgct cagggaaaag cagctctccc ctcagagtgc 1440
aagcccctgc tccagaagat agcttcaccc caatcccagc tacctcaacc aatgccaaaa 1500
aaagacaggg ctgataagct aacaccagac agacaacact gggaaacaga ggctattgtc 1560
ccctaaacca aaaactgaaa gtgaaagtcc agaaactgtt cccacctgct ggagtgaagg 1620
ggccaaggag ggtgagtgca aggggcgtgg gagtggcctg aagagtcctc tgaatgaacc 1680
ttctggcctc ccacagactc aaatgctcag accagctctt ccgaaaacca ggccttatct 1740
ccaagaccag agatagtggg gagacttctt ggcttggtga ggaaaagcgg acatcagctg 1800
gtcaaacaaa ctctctgaac ccctccctcc atcgttttct tcactgtcct ccaagccagc 1860
gggaatggca gctgccacgc cgccctaaaa gcacactcat cccctcactt gccgcgtcgc 1920
cctcccaggc tctcaacagg ggagagtgtg gtgtttcctg caggccaggc cagctgcctc 1980
cgcgtgatca aagccacact ctgggctcca gagtggggat gacatgcact cagctcttgg 2040
ctccactggg atgggaggag aggacaaggg aaatgtcagg ggcggggagg gtgacagtgg 2100
ccgcccaagg cccacgagct tgttctttgt tctttgtcac agggactgaa aacctctcct 2160
catgttctgc tttcgattcg ttaagagagc aacattttac ccacacacag ataaagtttt 2220
cccttgagga aacaacagct ttaaaagaaa aagaaaaaaa aagtctttgg taaatggcaa 2280
aaaaaaaaaa aaaaaaaaaa aaa                                         2303

<210> 9
<211> 2207
<212> DNA
<213> Homo sapiens

<220> 
<223> Exemplary nucleic acid sequence encoding human CCR7 isoform a,
GenBank Accession No. NM_001838.3 

<400> 9
cacttcctcc ccagacaggg gtagtgcgag gccgggcaca gccttcctgt gtggttttac 60
cgcccagaga gcgtcatgga cctggggaaa ccaatgaaaa gcgtgctggt ggtggctctc 120
cttgtcattt tccaggtatg cctgtgtcaa gatgaggtca cggacgatta catcggagac 180
aacaccacag tggactacac tttgttcgag tctttgtgct ccaagaagga cgtgcggaac 240
tttaaagcct ggttcctccc tatcatgtac tccatcattt gtttcgtggg cctactgggc 300
aatgggctgg tcgtgttgac ctatatctat ttcaagaggc tcaagaccat gaccgatacc 360
tacctgctca acctggcggt ggcagacatc ctcttcctcc tgacccttcc cttctgggcc 420
tacagcgcgg ccaagtcctg ggtcttcggt gtccactttt gcaagctcat ctttgccatc 480
tacaagatga gcttcttcag tggcatgctc ctacttcttt gcatcagcat tgaccgctac 540
gtggccatcg tccaggctgt ctcagctcac cgccaccgtg cccgcgtcct tctcatcagc 600
aagctgtcct gtgtgggcat ctggatacta gccacagtgc tctccatccc agagctcctg 660
tacagtgacc tccagaggag cagcagtgag caagcgatgc gatgctctct catcacagag 720
catgtggagg cctttatcac catccaggtg gcccagatgg tgatcggctt tctggtcccc 780
ctgctggcca tgagcttctg ttaccttgtc atcatccgca ccctgctcca ggcacgcaac 840
tttgagcgca acaaggccat caaggtgatc atcgctgtgg tcgtggtctt catagtcttc 900
cagctgccct acaatggggt ggtcctggcc cagacggtgg ccaacttcaa catcaccagt 960
agcacctgtg agctcagtaa gcaactcaac atcgcctacg acgtcaccta cagcctggcc 1020
tgcgtccgct gctgcgtcaa ccctttcttg tacgccttca tcggcgtcaa gttccgcaac 1080
gatctcttca agctcttcaa ggacctgggc tgcctcagcc aggagcagct ccggcagtgg 1140
tcttcctgtc ggcacatccg gcgctcctcc atgagtgtgg aggccgagac caccaccacc 1200
ttctccccat aggcgactct tctgcctgga ctagagggac ctctcccagg gtccctgggg 1260
tggggatagg gagcagatgc aatgactcag gacatccccc cgccaaaagc tgctcaggga 1320
aaagcagctc tcccctcaga gtgcaagccc ctgctccaga agatagcttc accccaatcc 1380
cagctacctc aaccaatgcc aaaaaaagac agggctgata agctaacacc agacagacaa 1440
cactgggaaa cagaggctat tgtcccctaa accaaaaact gaaagtgaaa gtccagaaac 1500
tgttcccacc tgctggagtg aaggggccaa ggagggtgag tgcaaggggc gtgggagtgg 1560
cctgaagagt cctctgaatg aaccttctgg cctcccacag actcaaatgc tcagaccagc 1620
tcttccgaaa accaggcctt atctccaaga ccagagatag tggggagact tcttggcttg 1680
gtgaggaaaa gcggacatca gctggtcaaa caaactctct gaacccctcc ctccatcgtt 1740
ttcttcactg tcctccaagc cagcgggaat ggcagctgcc acgccgccct aaaagcacac 1800
tcatcccctc acttgccgcg tcgccctccc aggctctcaa caggggagag tgtggtgttt 1860
cctgcaggcc aggccagctg cctccgcgtg atcaaagcca cactctgggc tccagagtgg 1920
ggatgacatg cactcagctc ttggctccac tgggatggga ggagaggaca agggaaatgt 1980
caggggcggg gagggtgaca gtggccgccc aaggcccacg agcttgttct ttgttctttg 2040
tcacagggac tgaaaacctc tcctcatgtt ctgctttcga ttcgttaaga gagcaacatt 2100
ttacccacac acagataaag ttttcccttg aggaaacaac agctttaaaa gaaaaagaaa 2160
aaaaaagtct ttggtaaatg gcaaaaaaaa aaaaaaaaaa aaaaaaa               2207

<210> 10
<211> 315
<212> PRT
<213> Homo sapiens

<220> 
<223> Exemplary amino acid sequence of human CCR7 isoform b,
GenBank Accession No. NP_001288643.1

<400> 10
Met Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val
 1               5                  10                  15      
Val Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr
            20                  25                  30          
Tyr Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu
        35                  40                  45              
Pro Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His
    50                  55                  60                  
Phe Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly
65                  70                  75                  80  
Met Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val
                85                  90                  95      
Gln Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser
            100                 105                 110         
Lys Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile
        115                 120                 125             
Pro Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala
    130                 135                 140                 
Met Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile
145                 150                 155                 160 
Gln Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met
                165                 170                 175     
Ser Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn
            180                 185                 190         
Phe Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val
        195                 200                 205             
Phe Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr
    210                 215                 220                 
Val Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln
225                 230                 235                 240 
Leu Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys
                245                 250                 255     
Cys Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn
            260                 265                 270         
Asp Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln
        275                 280                 285             
Leu Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser
    290                 295                 300                 
Val Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro
305                 310                 315 


<210> 11
<211> 372
<212> PRT
<213> Homo sapiens

<220> 
<223> Exemplary amino acid sequence of human CCR7 isoform c,
GenBank Accession No. NP_001288645.1

<400> 11
Met Lys Ser Val Leu Val Val Ala Leu Leu Val Ile Phe Gln Val Cys
 1               5                  10                  15      
Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr Ile Gly Asp Asn Thr Thr
            20                  25                  30          
Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys Ser Lys Lys Asp Val Arg
        35                  40                  45              
Asn Phe Lys Ala Trp Phe Leu Pro Ile Met Tyr Ser Ile Ile Cys Phe
    50                  55                  60                  
Val Gly Leu Leu Gly Asn Gly Leu Val Val Leu Thr Tyr Ile Tyr Phe
65                  70                  75                  80  
Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr Leu Leu Asn Leu Ala Val
                85                  90                  95      
Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro Phe Trp Ala Tyr Ser Ala
            100                 105                 110         
Ala Lys Ser Trp Val Phe Gly Val His Phe Cys Lys Leu Ile Phe Ala
        115                 120                 125             
Ile Tyr Lys Met Ser Phe Phe Ser Gly Met Leu Leu Leu Leu Cys Ile
    130                 135                 140                 
Ser Ile Asp Arg Tyr Val Ala Ile Val Gln Ala Val Ser Ala His Arg
145                 150                 155                 160 
His Arg Ala Arg Val Leu Leu Ile Ser Lys Leu Ser Cys Val Gly Ile
                165                 170                 175     
Trp Ile Leu Ala Thr Val Leu Ser Ile Pro Glu Leu Leu Tyr Ser Asp
            180                 185                 190         
Leu Gln Arg Ser Ser Ser Glu Gln Ala Met Arg Cys Ser Leu Ile Thr
        195                 200                 205             
Glu His Val Glu Ala Phe Ile Thr Ile Gln Val Ala Gln Met Val Ile
    210                 215                 220                 
Gly Phe Leu Val Pro Leu Leu Ala Met Ser Phe Cys Tyr Leu Val Ile
225                 230                 235                 240 
Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe Glu Arg Asn Lys Ala Ile
                245                 250                 255     
Lys Val Ile Ile Ala Val Val Val Val Phe Ile Val Phe Gln Leu Pro
            260                 265                 270         
Tyr Asn Gly Val Val Leu Ala Gln Thr Val Ala Asn Phe Asn Ile Thr
        275                 280                 285             
Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu Asn Ile Ala Tyr Asp Val
    290                 295                 300                 
Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys Val Asn Pro Phe Leu Tyr
305                 310                 315                 320 
Ala Phe Ile Gly Val Lys Phe Arg Asn Asp Leu Phe Lys Leu Phe Lys
                325                 330                 335     
Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu Arg Gln Trp Ser Ser Cys
            340                 345                 350         
Arg His Ile Arg Arg Ser Ser Met Ser Val Glu Ala Glu Thr Thr Thr
        355                 360                 365             
Thr Phe Ser Pro
    370         


<210> 12
<211> 372
<212> PRT
<213> Homo sapiens

<220> 
<223> Exemplary amino acid sequence of human CCR7 isoform c,
GenBank Accession No. NP_001288646.1

<400> 12
Met Lys Ser Val Leu Val Val Ala Leu Leu Val Ile Phe Gln Val Cys
 1               5                  10                  15      
Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr Ile Gly Asp Asn Thr Thr
            20                  25                  30          
Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys Ser Lys Lys Asp Val Arg
        35                  40                  45              
Asn Phe Lys Ala Trp Phe Leu Pro Ile Met Tyr Ser Ile Ile Cys Phe
    50                  55                  60                  
Val Gly Leu Leu Gly Asn Gly Leu Val Val Leu Thr Tyr Ile Tyr Phe
65                  70                  75                  80  
Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr Leu Leu Asn Leu Ala Val
                85                  90                  95      
Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro Phe Trp Ala Tyr Ser Ala
            100                 105                 110         
Ala Lys Ser Trp Val Phe Gly Val His Phe Cys Lys Leu Ile Phe Ala
        115                 120                 125             
Ile Tyr Lys Met Ser Phe Phe Ser Gly Met Leu Leu Leu Leu Cys Ile
    130                 135                 140                 
Ser Ile Asp Arg Tyr Val Ala Ile Val Gln Ala Val Ser Ala His Arg
145                 150                 155                 160 
His Arg Ala Arg Val Leu Leu Ile Ser Lys Leu Ser Cys Val Gly Ile
                165                 170                 175     
Trp Ile Leu Ala Thr Val Leu Ser Ile Pro Glu Leu Leu Tyr Ser Asp
            180                 185                 190         
Leu Gln Arg Ser Ser Ser Glu Gln Ala Met Arg Cys Ser Leu Ile Thr
        195                 200                 205             
Glu His Val Glu Ala Phe Ile Thr Ile Gln Val Ala Gln Met Val Ile
    210                 215                 220                 
Gly Phe Leu Val Pro Leu Leu Ala Met Ser Phe Cys Tyr Leu Val Ile
225                 230                 235                 240 
Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe Glu Arg Asn Lys Ala Ile
                245                 250                 255     
Lys Val Ile Ile Ala Val Val Val Val Phe Ile Val Phe Gln Leu Pro
            260                 265                 270         
Tyr Asn Gly Val Val Leu Ala Gln Thr Val Ala Asn Phe Asn Ile Thr
        275                 280                 285             
Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu Asn Ile Ala Tyr Asp Val
    290                 295                 300                 
Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys Val Asn Pro Phe Leu Tyr
305                 310                 315                 320 
Ala Phe Ile Gly Val Lys Phe Arg Asn Asp Leu Phe Lys Leu Phe Lys
                325                 330                 335     
Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu Arg Gln Trp Ser Ser Cys
            340                 345                 350         
Arg His Ile Arg Arg Ser Ser Met Ser Val Glu Ala Glu Thr Thr Thr
        355                 360                 365             
Thr Phe Ser Pro
    370         


<210> 13
<211> 372
<212> PRT
<213> Homo sapiens

<220> 
<223> Exemplary amino acid sequence of human CCR7 isoform c,
GenBank Accession No. NP_001288647.1

<400> 13
Met Lys Ser Val Leu Val Val Ala Leu Leu Val Ile Phe Gln Val Cys
 1               5                  10                  15      
Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr Ile Gly Asp Asn Thr Thr
            20                  25                  30          
Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys Ser Lys Lys Asp Val Arg
        35                  40                  45              
Asn Phe Lys Ala Trp Phe Leu Pro Ile Met Tyr Ser Ile Ile Cys Phe
    50                  55                  60                  
Val Gly Leu Leu Gly Asn Gly Leu Val Val Leu Thr Tyr Ile Tyr Phe
65                  70                  75                  80  
Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr Leu Leu Asn Leu Ala Val
                85                  90                  95      
Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro Phe Trp Ala Tyr Ser Ala
            100                 105                 110         
Ala Lys Ser Trp Val Phe Gly Val His Phe Cys Lys Leu Ile Phe Ala
        115                 120                 125             
Ile Tyr Lys Met Ser Phe Phe Ser Gly Met Leu Leu Leu Leu Cys Ile
    130                 135                 140                 
Ser Ile Asp Arg Tyr Val Ala Ile Val Gln Ala Val Ser Ala His Arg
145                 150                 155                 160 
His Arg Ala Arg Val Leu Leu Ile Ser Lys Leu Ser Cys Val Gly Ile
                165                 170                 175     
Trp Ile Leu Ala Thr Val Leu Ser Ile Pro Glu Leu Leu Tyr Ser Asp
            180                 185                 190         
Leu Gln Arg Ser Ser Ser Glu Gln Ala Met Arg Cys Ser Leu Ile Thr
        195                 200                 205             
Glu His Val Glu Ala Phe Ile Thr Ile Gln Val Ala Gln Met Val Ile
    210                 215                 220                 
Gly Phe Leu Val Pro Leu Leu Ala Met Ser Phe Cys Tyr Leu Val Ile
225                 230                 235                 240 
Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe Glu Arg Asn Lys Ala Ile
                245                 250                 255     
Lys Val Ile Ile Ala Val Val Val Val Phe Ile Val Phe Gln Leu Pro
            260                 265                 270         
Tyr Asn Gly Val Val Leu Ala Gln Thr Val Ala Asn Phe Asn Ile Thr
        275                 280                 285             
Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu Asn Ile Ala Tyr Asp Val
    290                 295                 300                 
Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys Val Asn Pro Phe Leu Tyr
305                 310                 315                 320 
Ala Phe Ile Gly Val Lys Phe Arg Asn Asp Leu Phe Lys Leu Phe Lys
                325                 330                 335     
Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu Arg Gln Trp Ser Ser Cys
            340                 345                 350         
Arg His Ile Arg Arg Ser Ser Met Ser Val Glu Ala Glu Thr Thr Thr
        355                 360                 365             
Thr Phe Ser Pro
    370         


<210> 14
<211> 378
<212> PRT
<213> Homo sapiens

<220> 
<223> Exemplary amino acid sequence of human CCR7 isoform a,
GenBank Accession No. NP_001829.1

<400> 14
Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu
 1               5                  10                  15      
Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr
            20                  25                  30          
Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys
        35                  40                  45              
Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met
    50                  55                  60                  
Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val
65                  70                  75                  80  
Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr
                85                  90                  95      
Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro
            100                 105                 110         
Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe
        115                 120                 125             
Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met
    130                 135                 140                 
Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln
145                 150                 155                 160 
Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys
                165                 170                 175     
Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro
            180                 185                 190         
Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met
        195                 200                 205             
Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln
    210                 215                 220                 
Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser
225                 230                 235                 240 
Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe
                245                 250                 255     
Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe
            260                 265                 270         
Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val
        275                 280                 285             
Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu
    290                 295                 300                 
Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys
305                 310                 315                 320 
Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp
                325                 330                 335     
Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu
            340                 345                 350         
Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val
        355                 360                 365             
Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro
    370                 375             


<210> 15
<211> 6055
<212> DNA
<213> Homo sapiens

<220> 
<223> Exemplary nucleic acid sequence encoding human VEGFR2 precursor,
GenBank Accession No. NM_002253.2

<400> 15
actgagtccc gggaccccgg gagagcggtc aatgtgtggt cgctgcgttt cctctgcctg 60
cgccgggcat cacttgcgcg ccgcagaaag tccgtctggc agcctggata tcctctccta 120
ccggcacccg cagacgcccc tgcagccgcg gtcggcgccc gggctcccta gccctgtgcg 180
ctcaactgtc ctgcgctgcg gggtgccgcg agttccacct ccgcgcctcc ttctctagac 240
aggcgctggg agaaagaacc ggctcccgag ttctgggcat ttcgcccggc tcgaggtgca 300
ggatgcagag caaggtgctg ctggccgtcg ccctgtggct ctgcgtggag acccgggccg 360
cctctgtggg tttgcctagt gtttctcttg atctgcccag gctcagcata caaaaagaca 420
tacttacaat taaggctaat acaactcttc aaattacttg caggggacag agggacttgg 480
actggctttg gcccaataat cagagtggca gtgagcaaag ggtggaggtg actgagtgca 540
gcgatggcct cttctgtaag acactcacaa ttccaaaagt gatcggaaat gacactggag 600
cctacaagtg cttctaccgg gaaactgact tggcctcggt catttatgtc tatgttcaag 660
attacagatc tccatttatt gcttctgtta gtgaccaaca tggagtcgtg tacattactg 720
agaacaaaaa caaaactgtg gtgattccat gtctcgggtc catttcaaat ctcaacgtgt 780
cactttgtgc aagataccca gaaaagagat ttgttcctga tggtaacaga atttcctggg 840
acagcaagaa gggctttact attcccagct acatgatcag ctatgctggc atggtcttct 900
gtgaagcaaa aattaatgat gaaagttacc agtctattat gtacatagtt gtcgttgtag 960
ggtataggat ttatgatgtg gttctgagtc cgtctcatgg aattgaacta tctgttggag 1020
aaaagcttgt cttaaattgt acagcaagaa ctgaactaaa tgtggggatt gacttcaact 1080
gggaataccc ttcttcgaag catcagcata agaaacttgt aaaccgagac ctaaaaaccc 1140
agtctgggag tgagatgaag aaatttttga gcaccttaac tatagatggt gtaacccgga 1200
gtgaccaagg attgtacacc tgtgcagcat ccagtgggct gatgaccaag aagaacagca 1260
catttgtcag ggtccatgaa aaaccttttg ttgcttttgg aagtggcatg gaatctctgg 1320
tggaagccac ggtgggggag cgtgtcagaa tccctgcgaa gtaccttggt tacccacccc 1380
cagaaataaa atggtataaa aatggaatac cccttgagtc caatcacaca attaaagcgg 1440
ggcatgtact gacgattatg gaagtgagtg aaagagacac aggaaattac actgtcatcc 1500
ttaccaatcc catttcaaag gagaagcaga gccatgtggt ctctctggtt gtgtatgtcc 1560
caccccagat tggtgagaaa tctctaatct ctcctgtgga ttcctaccag tacggcacca 1620
ctcaaacgct gacatgtacg gtctatgcca ttcctccccc gcatcacatc cactggtatt 1680
ggcagttgga ggaagagtgc gccaacgagc ccagccaagc tgtctcagtg acaaacccat 1740
acccttgtga agaatggaga agtgtggagg acttccaggg aggaaataaa attgaagtta 1800
ataaaaatca atttgctcta attgaaggaa aaaacaaaac tgtaagtacc cttgttatcc 1860
aagcggcaaa tgtgtcagct ttgtacaaat gtgaagcggt caacaaagtc gggagaggag 1920
agagggtgat ctccttccac gtgaccaggg gtcctgaaat tactttgcaa cctgacatgc 1980
agcccactga gcaggagagc gtgtctttgt ggtgcactgc agacagatct acgtttgaga 2040
acctcacatg gtacaagctt ggcccacagc ctctgccaat ccatgtggga gagttgccca 2100
cacctgtttg caagaacttg gatactcttt ggaaattgaa tgccaccatg ttctctaata 2160
gcacaaatga cattttgatc atggagctta agaatgcatc cttgcaggac caaggagact 2220
atgtctgcct tgctcaagac aggaagacca agaaaagaca ttgcgtggtc aggcagctca 2280
cagtcctaga gcgtgtggca cccacgatca caggaaacct ggagaatcag acgacaagta 2340
ttggggaaag catcgaagtc tcatgcacgg catctgggaa tccccctcca cagatcatgt 2400
ggtttaaaga taatgagacc cttgtagaag actcaggcat tgtattgaag gatgggaacc 2460
ggaacctcac tatccgcaga gtgaggaagg aggacgaagg cctctacacc tgccaggcat 2520
gcagtgttct tggctgtgca aaagtggagg catttttcat aatagaaggt gcccaggaaa 2580
agacgaactt ggaaatcatt attctagtag gcacggcggt gattgccatg ttcttctggc 2640
tacttcttgt catcatccta cggaccgtta agcgggccaa tggaggggaa ctgaagacag 2700
gctacttgtc catcgtcatg gatccagatg aactcccatt ggatgaacat tgtgaacgac 2760
tgccttatga tgccagcaaa tgggaattcc ccagagaccg gctgaagcta ggtaagcctc 2820
ttggccgtgg tgcctttggc caagtgattg aagcagatgc ctttggaatt gacaagacag 2880
caacttgcag gacagtagca gtcaaaatgt tgaaagaagg agcaacacac agtgagcatc 2940
gagctctcat gtctgaactc aagatcctca ttcatattgg tcaccatctc aatgtggtca 3000
accttctagg tgcctgtacc aagccaggag ggccactcat ggtgattgtg gaattctgca 3060
aatttggaaa cctgtccact tacctgagga gcaagagaaa tgaatttgtc ccctacaaga 3120
ccaaaggggc acgattccgt caagggaaag actacgttgg agcaatccct gtggatctga 3180
aacggcgctt ggacagcatc accagtagcc agagctcagc cagctctgga tttgtggagg 3240
agaagtccct cagtgatgta gaagaagagg aagctcctga agatctgtat aaggacttcc 3300
tgaccttgga gcatctcatc tgttacagct tccaagtggc taagggcatg gagttcttgg 3360
catcgcgaaa gtgtatccac agggacctgg cggcacgaaa tatcctctta tcggagaaga 3420
acgtggttaa aatctgtgac tttggcttgg cccgggatat ttataaagat ccagattatg 3480
tcagaaaagg agatgctcgc ctccctttga aatggatggc cccagaaaca atttttgaca 3540
gagtgtacac aatccagagt gacgtctggt cttttggtgt tttgctgtgg gaaatatttt 3600
ccttaggtgc ttctccatat cctggggtaa agattgatga agaattttgt aggcgattga 3660
aagaaggaac tagaatgagg gcccctgatt atactacacc agaaatgtac cagaccatgc 3720
tggactgctg gcacggggag cccagtcaga gacccacgtt ttcagagttg gtggaacatt 3780
tgggaaatct cttgcaagct aatgctcagc aggatggcaa agactacatt gttcttccga 3840
tatcagagac tttgagcatg gaagaggatt ctggactctc tctgcctacc tcacctgttt 3900
cctgtatgga ggaggaggaa gtatgtgacc ccaaattcca ttatgacaac acagcaggaa 3960
tcagtcagta tctgcagaac agtaagcgaa agagccggcc tgtgagtgta aaaacatttg 4020
aagatatccc gttagaagaa ccagaagtaa aagtaatccc agatgacaac cagacggaca 4080
gtggtatggt tcttgcctca gaagagctga aaactttgga agacagaacc aaattatctc 4140
catcttttgg tggaatggtg cccagcaaaa gcagggagtc tgtggcatct gaaggctcaa 4200
accagacaag cggctaccag tccggatatc actccgatga cacagacacc accgtgtact 4260
ccagtgagga agcagaactt ttaaagctga tagagattgg agtgcaaacc ggtagcacag 4320
cccagattct ccagcctgac tcggggacca cactgagctc tcctcctgtt taaaaggaag 4380
catccacacc cccaactcct ggacatcaca tgagaggtgc tgctcagatt ttcaagtgtt 4440
gttctttcca ccagcaggaa gtagccgcat ttgattttca tttcgacaac agaaaaagga 4500
cctcggactg cagggagcca gtcttctagg catatcctgg aagaggcttg tgacccaaga 4560
atgtgtctgt gtcttctccc agtgttgacc tgatcctctt tttcattcat ttaaaaagca 4620
tttatcatgc cccctgctgc gggtctcacc atgggtttag aacaaagacg ttcaagaaat 4680
ggccccatcc tcaaagaagt agcagtacct ggggagctga cacttctgta aaactagaag 4740
ataaaccagg caatgtaagt gttcgaggtg ttgaagatgg gaaggatttg cagggctgag 4800
tctatccaag aggctttgtt taggacgtgg gtcccaagcc aagccttaag tgtggaattc 4860
ggattgatag aaaggaagac taacgttacc ttgctttgga gagtactgga gcctgcaaat 4920
gcattgtgtt tgctctggtg gaggtgggca tggggtctgt tctgaaatgt aaagggttca 4980
gacggggttt ctggttttag aaggttgcgt gttcttcgag ttgggctaaa gtagagttcg 5040
ttgtgctgtt tctgactcct aatgagagtt ccttccagac cgttacgtgt ctcctggcca 5100
agccccagga aggaaatgat gcagctctgg ctccttgtct cccaggctga tcctttattc 5160
agaataccac aaagaaagga cattcagctc aaggctccct gccgtgttga agagttctga 5220
ctgcacaaac cagcttctgg tttcttctgg aatgaatacc ctcatatctg tcctgatgtg 5280
atatgtctga gactgaatgc gggaggttca atgtgaagct gtgtgtggtg tcaaagtttc 5340
aggaaggatt ttaccctttt gttcttcccc ctgtccccaa cccactctca ccccgcaacc 5400
catcagtatt ttagttattt ggcctctact ccagtaaacc tgattgggtt tgttcactct 5460
ctgaatgatt attagccaga cttcaaaatt attttatagc ccaaattata acatctattg 5520
tattatttag acttttaaca tatagagcta tttctactga tttttgccct tgttctgtcc 5580
tttttttcaa aaaagaaaat gtgttttttg tttggtacca tagtgtgaaa tgctgggaac 5640
aatgactata agacatgcta tggcacatat atttatagtc tgtttatgta gaaacaaatg 5700
taatatatta aagccttata tataatgaac tttgtactat tcacattttg tatcagtatt 5760
atgtagcata acaaaggtca taatgctttc agcaattgat gtcattttat taaagaacat 5820
tgaaaaactt gaaggaatcc ctttgcaagg ttgcattact gtacccatca tttctaaaat 5880
ggaagagggg gtggctgggc acagtggccg acacctaaaa acccagcact ttggggggcc 5940
aaggtgggag gatcgcttga gcccaggagt tcaagaccag tctggccaac atggtcagat 6000
tccatctcaa agaaaaaagg taaaaataaa ataaaatgga gaagaaggaa tcaga      6055



<210> 16
<211> 1356
<212> PRT
<213> Homo sapiens

<220> 
<223> Exemplary amino acid sequence of human VEGFR2 precursor,
GenBank Accession No. NP_002244.1

<400> 16
Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu
 1               5                  10                  15      
Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro
            20                  25                  30          
Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr
        35                  40                  45              
Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro
    50                  55                  60                  
Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser
65                  70                  75                  80  
Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn
                85                  90                  95      
Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser
            100                 105                 110         
Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser
        115                 120                 125             
Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys
    130                 135                 140                 
Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser
145                 150                 155                 160 
Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg
                165                 170                 175     
Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile
            180                 185                 190         
Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser
        195                 200                 205             
Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr
    210                 215                 220                 
Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu
225                 230                 235                 240 
Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile
                245                 250                 255     
Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu
            260                 265                 270         
Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe
        275                 280                 285             
Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu
    290                 295                 300                 
Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr
305                 310                 315                 320 
Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met
                325                 330                 335     
Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala
            340                 345                 350         
Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly
        355                 360                 365             
Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr
    370                 375                 380                 
Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu
385                 390                 395                 400 
Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val
                405                 410                 415     
Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val
            420                 425                 430         
Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr
        435                 440                 445             
Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu
    450                 455                 460                 
Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr
465                 470                 475                 480 
Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys
                485                 490                 495     
Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys
            500                 505                 510         
Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr
        515                 520                 525             
Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser
    530                 535                 540                 
Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln
545                 550                 555                 560 
Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser
                565                 570                 575     
Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro
            580                 585                 590         
Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr
        595                 600                 605             
Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile
    610                 615                 620                 
Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr
625                 630                 635                 640 
Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val
                645                 650                 655     
Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn
            660                 665                 670         
Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys
        675                 680                 685             
Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn
    690                 695                 700                 
Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg
705                 710                 715                 720 
Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr
                725                 730                 735     
Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe
            740                 745                 750         
Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu Ile Ile Ile Leu
        755                 760                 765             
Val Gly Thr Ala Val Ile Ala Met Phe Phe Trp Leu Leu Leu Val Ile
    770                 775                 780                 
Ile Leu Arg Thr Val Lys Arg Ala Asn Gly Gly Glu Leu Lys Thr Gly
785                 790                 795                 800 
Tyr Leu Ser Ile Val Met Asp Pro Asp Glu Leu Pro Leu Asp Glu His
                805                 810                 815     
Cys Glu Arg Leu Pro Tyr Asp Ala Ser Lys Trp Glu Phe Pro Arg Asp
            820                 825                 830         
Arg Leu Lys Leu Gly Lys Pro Leu Gly Arg Gly Ala Phe Gly Gln Val
        835                 840                 845             
Ile Glu Ala Asp Ala Phe Gly Ile Asp Lys Thr Ala Thr Cys Arg Thr
    850                 855                 860                 
Val Ala Val Lys Met Leu Lys Glu Gly Ala Thr His Ser Glu His Arg
865                 870                 875                 880 
Ala Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly His His Leu
                885                 890                 895     
Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gly Gly Pro Leu
            900                 905                 910         
Met Val Ile Val Glu Phe Cys Lys Phe Gly Asn Leu Ser Thr Tyr Leu
        915                 920                 925             
Arg Ser Lys Arg Asn Glu Phe Val Pro Tyr Lys Thr Lys Gly Ala Arg
    930                 935                 940                 
Phe Arg Gln Gly Lys Asp Tyr Val Gly Ala Ile Pro Val Asp Leu Lys
945                 950                 955                 960 
Arg Arg Leu Asp Ser Ile Thr Ser Ser Gln Ser Ser Ala Ser Ser Gly
                965                 970                 975     
Phe Val Glu Glu Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Ala Pro
            980                 985                 990         
Glu Asp Leu Tyr Lys Asp Phe Leu Thr Leu Glu His Leu Ile Cys Tyr
        995                 1000                1005            
Ser Phe Gln Val Ala Lys Gly Met Glu Phe Leu Ala Ser Arg Lys Cys
    1010                1015                1020                
Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu Ser Glu Lys Asn
1025                1030                1035                1040
Val Val Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Tyr Lys Asp
                1045                1050                1055    
Pro Asp Tyr Val Arg Lys Gly Asp Ala Arg Leu Pro Leu Lys Trp Met
            1060                1065                1070        
Ala Pro Glu Thr Ile Phe Asp Arg Val Tyr Thr Ile Gln Ser Asp Val
        1075                1080                1085            
Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser Leu Gly Ala Ser
    1090                1095                1100                
Pro Tyr Pro Gly Val Lys Ile Asp Glu Glu Phe Cys Arg Arg Leu Lys
1105                1110                1115                1120
Glu Gly Thr Arg Met Arg Ala Pro Asp Tyr Thr Thr Pro Glu Met Tyr
                1125                1130                1135    
Gln Thr Met Leu Asp Cys Trp His Gly Glu Pro Ser Gln Arg Pro Thr
            1140                1145                1150        
Phe Ser Glu Leu Val Glu His Leu Gly Asn Leu Leu Gln Ala Asn Ala
        1155                1160                1165            
Gln Gln Asp Gly Lys Asp Tyr Ile Val Leu Pro Ile Ser Glu Thr Leu
    1170                1175                1180                
Ser Met Glu Glu Asp Ser Gly Leu Ser Leu Pro Thr Ser Pro Val Ser
1185                1190                1195                1200
Cys Met Glu Glu Glu Glu Val Cys Asp Pro Lys Phe His Tyr Asp Asn
                1205                1210                1215    
Thr Ala Gly Ile Ser Gln Tyr Leu Gln Asn Ser Lys Arg Lys Ser Arg
            1220                1225                1230        
Pro Val Ser Val Lys Thr Phe Glu Asp Ile Pro Leu Glu Glu Pro Glu
        1235                1240                1245            
Val Lys Val Ile Pro Asp Asp Asn Gln Thr Asp Ser Gly Met Val Leu
    1250                1255                1260                
Ala Ser Glu Glu Leu Lys Thr Leu Glu Asp Arg Thr Lys Leu Ser Pro
1265                1270                1275                1280
Ser Phe Gly Gly Met Val Pro Ser Lys Ser Arg Glu Ser Val Ala Ser
                1285                1290                1295    
Glu Gly Ser Asn Gln Thr Ser Gly Tyr Gln Ser Gly Tyr His Ser Asp
            1300                1305                1310        
Asp Thr Asp Thr Thr Val Tyr Ser Ser Glu Glu Ala Glu Leu Leu Lys
        1315                1320                1325            
Leu Ile Glu Ile Gly Val Gln Thr Gly Ser Thr Ala Gln Ile Leu Gln
    1330                1335                1340                
Pro Asp Ser Gly Thr Thr Leu Ser Ser Pro Pro Val
1345                1350                1355    


<210> 17
<211> 2919
<212> DNA
<213> Homo sapiens

<220> 
<223> Exemplary nucleic acid sequence encoding human CXCR5,
GenBank Accession No. NM_001716.4

<400> 17
aaaaaaaaaa agtgatgagt tgtgaggcag gtcgcggccc tactgcctca ggagacgatg 60
cgcagctcat ttgcttaaat ttgcagctga cggctgccac ctctctagag gcacctggcg 120
gggagcctct caacataaga cagtgaccag tctggtgact cacagccggc acagccatga 180
actacccgct aacgctggaa atggacctcg agaacctgga ggacctgttc tgggaactgg 240
acagattgga caactataac gacacctccc tggtggaaaa tcatctctgc cctgccacag 300
aggggcccct catggcctcc ttcaaggccg tgttcgtgcc cgtggcctac agcctcatct 360
tcctcctggg cgtgatcggc aacgtcctgg tgctggtgat cctggagcgg caccggcaga 420
cacgcagttc cacggagacc ttcctgttcc acctggccgt ggccgacctc ctgctggtct 480
tcatcttgcc ctttgccgtg gccgagggct ctgtgggctg ggtcctgggg accttcctct 540
gcaaaactgt gattgccctg cacaaagtca acttctactg cagcagcctg ctcctggcct 600
gcatcgccgt ggaccgctac ctggccattg tccacgccgt ccatgcctac cgccaccgcc 660
gcctcctctc catccacatc acctgtggga ccatctggct ggtgggcttc ctccttgcct 720
tgccagagat tctcttcgcc aaagtcagcc aaggccatca caacaactcc ctgccacgtt 780
gcaccttctc ccaagagaac caagcagaaa cgcatgcctg gttcacctcc cgattcctct 840
accatgtggc gggattcctg ctgcccatgc tggtgatggg ctggtgctac gtgggggtag 900
tgcacaggtt gcgccaggcc cagcggcgcc ctcagcggca gaaggcagtc agggtggcca 960
tcctggtgac aagcatcttc ttcctctgct ggtcacccta ccacatcgtc atcttcctgg 1020
acaccctggc gaggctgaag gccgtggaca atacctgcaa gctgaatggc tctctccccg 1080
tggccatcac catgtgtgag ttcctgggcc tggcccactg ctgcctcaac cccatgctct 1140
acactttcgc cggcgtgaag ttccgcagtg acctgtcgcg gctcctgacg aagctgggct 1200
gtaccggccc tgcctccctg tgccagctct tccctagctg gcgcaggagc agtctctctg 1260
agtcagagaa tgccacctct ctcaccacgt tctaggtccc agtgtcccct tttattgctg 1320
cttttccttg gggcaggcag tgatgctgga tgctccttcc aacaggagct gggatcctaa 1380
gggctcaccg tggctaagag tgtcctagga gtatcctcat ttggggtagc tagaggaacc 1440
aacccccatt tctagaacat ccctgccagc tcttctgccg gccctggggc taggctggag 1500
cccagggagc ggaaagcagc tcaaaggcac agtgaaggct gtccttaccc atctgcaccc 1560
ccctgggctg agagaacctc acgcacctcc catcctaatc atccaatgct caagaaacaa 1620
cttctacttc tgcccttgcc aacggagagc gcctgcccct cccagaacac actccatcag 1680
cttaggggct gctgacctcc acagcttccc ctctctcctc ctgcccacct gtcaaacaaa 1740
gccagaagct gagcaccagg ggatgagtgg aggttaaggc tgaggaaagg ccagctggca 1800
gcagagtgtg gccttcggac aactcagtcc ctaaaaacac agacattctg ccaggccccc 1860
aagcctgcag tcatcttgac caagcaggaa gctcagactg gttgagttca ggtagctgcc 1920
cctggctctg accgaaacag cgctgggtcc accccatgtc accggatcct gggtggtctg 1980
caggcagggc tgactctagg tgcccttgga ggccagccag tgacctgagg aagcgtgaag 2040
gccgagaagc aagaaagaaa cccgacagag ggaagaaaag agctttcttc ccgaacccca 2100
aggagggaga tggatcaatc aaacccggcg gtcccctccg ccaggcgaga tggggtgggg 2160
tggagaactc ctagggtggc tgggtccagg ggatgggagg ttgtgggcat tgatggggaa 2220
ggaggctggc ttgtcccctc ctcactccct tcccataagc tatagacccg aggaaactca 2280
gagtcggaac ggagaaaggt ggactggaag gggcccgtgg gagtcatctc aaccatcccc 2340
tccgtggcat caccttaggc agggaagtgt aagaaacaca ctgaggcagg gaagtcccca 2400
ggccccagga agccgtgccc tgcccccgtg aggatgtcac tcagatggaa ccgcaggaag 2460
ctgctccgtg cttgtttgct cacctggggt gtgggaggcc cgtccggcag ttctgggtgc 2520
tccctaccac ctccccagcc tttgatcagg tggggagtca gggacccctg cccttgtccc 2580
actcaagcca agcagccaag ctccttggga ggccccactg gggaaataac agctgtggct 2640
cacgtgagag tgtcttcacg gcaggacaac gaggaagccc taagacgtcc cttttttctc 2700
tgagtatctc ctcgcaagct gggtaatcga tgggggagtc tgaagcagat gcaaagaggc 2760
aagaggctgg attttgaatt ttctttttaa taaaaaggca cctataaaac aggtcaatac 2820
agtacaggca gcacagagac ccccggaaca agcctaaaaa ttgtttcaaa ataaaaacca 2880
agaagatgtc ttcacatatt gtaaaaaaaa aaaaaaaaa                        2919

<210> 18
<211> 2896
<212> DNA
<213> Homo sapiens

<220> 
<223> Exemplary nucleic acid sequence encoding human CXCR5,
GenBank Accession No. NM_032966.2

<400> 18
ccactctaag gaatgcggtc cctttgacag gcgaaaaact gaagttggaa aagacaaagt 60
gatttgttca aaattgaaat ttgaaacttg acatttggtc agtgggccct atgtaggaaa 120
aaacctccaa gagagctagg gttcctctca gagaggaaag acaggtcctt aggtcctcac 180
cctcccgtct ccttgccctt gcagttctgg gaactggaca gattggacaa ctataacgac 240
acctccctgg tggaaaatca tctctgccct gccacagagg ggcccctcat ggcctccttc 300
aaggccgtgt tcgtgcccgt ggcctacagc ctcatcttcc tcctgggcgt gatcggcaac 360
gtcctggtgc tggtgatcct ggagcggcac cggcagacac gcagttccac ggagaccttc 420
ctgttccacc tggccgtggc cgacctcctg ctggtcttca tcttgccctt tgccgtggcc 480
gagggctctg tgggctgggt cctggggacc ttcctctgca aaactgtgat tgccctgcac 540
aaagtcaact tctactgcag cagcctgctc ctggcctgca tcgccgtgga ccgctacctg 600
gccattgtcc acgccgtcca tgcctaccgc caccgccgcc tcctctccat ccacatcacc 660
tgtgggacca tctggctggt gggcttcctc cttgccttgc cagagattct cttcgccaaa 720
gtcagccaag gccatcacaa caactccctg ccacgttgca ccttctccca agagaaccaa 780
gcagaaacgc atgcctggtt cacctcccga ttcctctacc atgtggcggg attcctgctg 840
cccatgctgg tgatgggctg gtgctacgtg ggggtagtgc acaggttgcg ccaggcccag 900
cggcgccctc agcggcagaa ggcagtcagg gtggccatcc tggtgacaag catcttcttc 960
ctctgctggt caccctacca catcgtcatc ttcctggaca ccctggcgag gctgaaggcc 1020
gtggacaata cctgcaagct gaatggctct ctccccgtgg ccatcaccat gtgtgagttc 1080
ctgggcctgg cccactgctg cctcaacccc atgctctaca ctttcgccgg cgtgaagttc 1140
cgcagtgacc tgtcgcggct cctgacgaag ctgggctgta ccggccctgc ctccctgtgc 1200
cagctcttcc ctagctggcg caggagcagt ctctctgagt cagagaatgc cacctctctc 1260
accacgttct aggtcccagt gtcccctttt attgctgctt ttccttgggg caggcagtga 1320
tgctggatgc tccttccaac aggagctggg atcctaaggg ctcaccgtgg ctaagagtgt 1380
cctaggagta tcctcatttg gggtagctag aggaaccaac ccccatttct agaacatccc 1440
tgccagctct tctgccggcc ctggggctag gctggagccc agggagcgga aagcagctca 1500
aaggcacagt gaaggctgtc cttacccatc tgcacccccc tgggctgaga gaacctcacg 1560
cacctcccat cctaatcatc caatgctcaa gaaacaactt ctacttctgc ccttgccaac 1620
ggagagcgcc tgcccctccc agaacacact ccatcagctt aggggctgct gacctccaca 1680
gcttcccctc tctcctcctg cccacctgtc aaacaaagcc agaagctgag caccagggga 1740
tgagtggagg ttaaggctga ggaaaggcca gctggcagca gagtgtggcc ttcggacaac 1800
tcagtcccta aaaacacaga cattctgcca ggcccccaag cctgcagtca tcttgaccaa 1860
gcaggaagct cagactggtt gagttcaggt agctgcccct ggctctgacc gaaacagcgc 1920
tgggtccacc ccatgtcacc ggatcctggg tggtctgcag gcagggctga ctctaggtgc 1980
ccttggaggc cagccagtga cctgaggaag cgtgaaggcc gagaagcaag aaagaaaccc 2040
gacagaggga agaaaagagc tttcttcccg aaccccaagg agggagatgg atcaatcaaa 2100
cccggcggtc ccctccgcca ggcgagatgg ggtggggtgg agaactccta gggtggctgg 2160
gtccagggga tgggaggttg tgggcattga tggggaagga ggctggcttg tcccctcctc 2220
actcccttcc cataagctat agacccgagg aaactcagag tcggaacgga gaaaggtgga 2280
ctggaagggg cccgtgggag tcatctcaac catcccctcc gtggcatcac cttaggcagg 2340
gaagtgtaag aaacacactg aggcagggaa gtccccaggc cccaggaagc cgtgccctgc 2400
ccccgtgagg atgtcactca gatggaaccg caggaagctg ctccgtgctt gtttgctcac 2460
ctggggtgtg ggaggcccgt ccggcagttc tgggtgctcc ctaccacctc cccagccttt 2520
gatcaggtgg ggagtcaggg acccctgccc ttgtcccact caagccaagc agccaagctc 2580
cttgggaggc cccactgggg aaataacagc tgtggctcac gtgagagtgt cttcacggca 2640
ggacaacgag gaagccctaa gacgtccctt ttttctctga gtatctcctc gcaagctggg 2700
taatcgatgg gggagtctga agcagatgca aagaggcaag aggctggatt ttgaattttc 2760
tttttaataa aaaggcacct ataaaacagg tcaatacagt acaggcagca cagagacccc 2820
cggaacaagc ctaaaaattg tttcaaaata aaaaccaaga agatgtcttc acatattgta 2880
aaaaaaaaaa aaaaaa                                                 2896

<210> 19
<211> 327
<212> PRT
<213> Homo sapiens

<220> 
<223> Exemplary amino acid sequence of human CXCR5,
GenBank Accession No. NP_116743.1

<400> 19
Met Ala Ser Phe Lys Ala Val Phe Val Pro Val Ala Tyr Ser Leu Ile
 1               5                  10                  15      
Phe Leu Leu Gly Val Ile Gly Asn Val Leu Val Leu Val Ile Leu Glu
            20                  25                  30          
Arg His Arg Gln Thr Arg Ser Ser Thr Glu Thr Phe Leu Phe His Leu
        35                  40                  45              
Ala Val Ala Asp Leu Leu Leu Val Phe Ile Leu Pro Phe Ala Val Ala
    50                  55                  60                  
Glu Gly Ser Val Gly Trp Val Leu Gly Thr Phe Leu Cys Lys Thr Val
65                  70                  75                  80  
Ile Ala Leu His Lys Val Asn Phe Tyr Cys Ser Ser Leu Leu Leu Ala
                85                  90                  95      
Cys Ile Ala Val Asp Arg Tyr Leu Ala Ile Val His Ala Val His Ala
            100                 105                 110         
Tyr Arg His Arg Arg Leu Leu Ser Ile His Ile Thr Cys Gly Thr Ile
        115                 120                 125             
Trp Leu Val Gly Phe Leu Leu Ala Leu Pro Glu Ile Leu Phe Ala Lys
    130                 135                 140                 
Val Ser Gln Gly His His Asn Asn Ser Leu Pro Arg Cys Thr Phe Ser
145                 150                 155                 160 
Gln Glu Asn Gln Ala Glu Thr His Ala Trp Phe Thr Ser Arg Phe Leu
                165                 170                 175     
Tyr His Val Ala Gly Phe Leu Leu Pro Met Leu Val Met Gly Trp Cys
            180                 185                 190         
Tyr Val Gly Val Val His Arg Leu Arg Gln Ala Gln Arg Arg Pro Gln
        195                 200                 205             
Arg Gln Lys Ala Val Arg Val Ala Ile Leu Val Thr Ser Ile Phe Phe
    210                 215                 220                 
Leu Cys Trp Ser Pro Tyr His Ile Val Ile Phe Leu Asp Thr Leu Ala
225                 230                 235                 240 
Arg Leu Lys Ala Val Asp Asn Thr Cys Lys Leu Asn Gly Ser Leu Pro
                245                 250                 255     
Val Ala Ile Thr Met Cys Glu Phe Leu Gly Leu Ala His Cys Cys Leu
            260                 265                 270         
Asn Pro Met Leu Tyr Thr Phe Ala Gly Val Lys Phe Arg Ser Asp Leu
        275                 280                 285             
Ser Arg Leu Leu Thr Lys Leu Gly Cys Thr Gly Pro Ala Ser Leu Cys
    290                 295                 300                 
Gln Leu Phe Pro Ser Trp Arg Arg Ser Ser Leu Ser Glu Ser Glu Asn
305                 310                 315                 320 
Ala Thr Ser Leu Thr Thr Phe
                325         


<210> 20
<211> 372
<212> PRT
<213> Homo sapiens

<220> 
<223> Exemplary amino acid sequence of human CXCR5,
GenBank Accession No. NP_001707.1

<400> 20
Met Asn Tyr Pro Leu Thr Leu Glu Met Asp Leu Glu Asn Leu Glu Asp
 1               5                  10                  15      
Leu Phe Trp Glu Leu Asp Arg Leu Asp Asn Tyr Asn Asp Thr Ser Leu
            20                  25                  30          
Val Glu Asn His Leu Cys Pro Ala Thr Glu Gly Pro Leu Met Ala Ser
        35                  40                  45              
Phe Lys Ala Val Phe Val Pro Val Ala Tyr Ser Leu Ile Phe Leu Leu
    50                  55                  60                  
Gly Val Ile Gly Asn Val Leu Val Leu Val Ile Leu Glu Arg His Arg
65                  70                  75                  80  
Gln Thr Arg Ser Ser Thr Glu Thr Phe Leu Phe His Leu Ala Val Ala
                85                  90                  95      
Asp Leu Leu Leu Val Phe Ile Leu Pro Phe Ala Val Ala Glu Gly Ser
            100                 105                 110         
Val Gly Trp Val Leu Gly Thr Phe Leu Cys Lys Thr Val Ile Ala Leu
        115                 120                 125             
His Lys Val Asn Phe Tyr Cys Ser Ser Leu Leu Leu Ala Cys Ile Ala
    130                 135                 140                 
Val Asp Arg Tyr Leu Ala Ile Val His Ala Val His Ala Tyr Arg His
145                 150                 155                 160 
Arg Arg Leu Leu Ser Ile His Ile Thr Cys Gly Thr Ile Trp Leu Val
                165                 170                 175     
Gly Phe Leu Leu Ala Leu Pro Glu Ile Leu Phe Ala Lys Val Ser Gln
            180                 185                 190         
Gly His His Asn Asn Ser Leu Pro Arg Cys Thr Phe Ser Gln Glu Asn
        195                 200                 205             
Gln Ala Glu Thr His Ala Trp Phe Thr Ser Arg Phe Leu Tyr His Val
    210                 215                 220                 
Ala Gly Phe Leu Leu Pro Met Leu Val Met Gly Trp Cys Tyr Val Gly
225                 230                 235                 240 
Val Val His Arg Leu Arg Gln Ala Gln Arg Arg Pro Gln Arg Gln Lys
                245                 250                 255     
Ala Val Arg Val Ala Ile Leu Val Thr Ser Ile Phe Phe Leu Cys Trp
            260                 265                 270         
Ser Pro Tyr His Ile Val Ile Phe Leu Asp Thr Leu Ala Arg Leu Lys
        275                 280                 285             
Ala Val Asp Asn Thr Cys Lys Leu Asn Gly Ser Leu Pro Val Ala Ile
    290                 295                 300                 
Thr Met Cys Glu Phe Leu Gly Leu Ala His Cys Cys Leu Asn Pro Met
305                 310                 315                 320 
Leu Tyr Thr Phe Ala Gly Val Lys Phe Arg Ser Asp Leu Ser Arg Leu
                325                 330                 335     
Leu Thr Lys Leu Gly Cys Thr Gly Pro Ala Ser Leu Cys Gln Leu Phe
            340                 345                 350         
Pro Ser Trp Arg Arg Ser Ser Leu Ser Glu Ser Glu Asn Ala Thr Ser
        355                 360                 365             
Leu Thr Thr Phe
    370         


<210> 21
<211> 2567
<212> DNA
<213> Homo sapiens

<220> 
<223> Exemplary nucleic acid sequence encoding human CCR9,
GenBank Accession No. NM_031200.2

<400> 21
gcttcctttc tcgtgttgtt atcgggtagc tgcctgctca gaacccacaa agcctgcccc 60
tcatcccagg cagagagcaa cccagctctt tccccagaca ctgagagctg gtggtgcctg 120
ctgtcccagg gagagttgca tcgccctcca cagagcaggc ttgcatctga ctgacccacc 180
atgacaccca cagacttcac aagccctatt cctaacatgg ctgatgacta tggctctgaa 240
tccacatctt ccatggaaga ctacgttaac ttcaacttca ctgacttcta ctgtgagaaa 300
aacaatgtca ggcagtttgc gagccatttc ctcccaccct tgtactggct cgtgttcatc 360
gtgggtgcct tgggcaacag tcttgttatc cttgtctact ggtactgcac aagagtgaag 420
accatgaccg acatgttcct tttgaatttg gcaattgctg acctcctctt tcttgtcact 480
cttcccttct gggccattgc tgctgctgac cagtggaagt tccagacctt catgtgcaag 540
gtggtcaaca gcatgtacaa gatgaacttc tacagctgtg tgttgctgat catgtgcatc 600
agcgtggaca ggtacattgc cattgcccag gccatgagag cacatacttg gagggagaaa 660
aggcttttgt acagcaaaat ggtttgcttt accatctggg tattggcagc tgctctctgc 720
atcccagaaa tcttatacag ccaaatcaag gaggaatccg gcattgctat ctgcaccatg 780
gtttacccta gcgatgagag caccaaactg aagtcagctg tcttgaccct gaaggtcatt 840
ctggggttct tccttccctt cgtggtcatg gcttgctgct ataccatcat cattcacacc 900
ctgatacaag ccaagaagtc ttccaagcac aaagccctaa aagtgaccat cactgtcctg 960
accgtctttg tcttgtctca gtttccctac aactgcattt tgttggtgca gaccattgac 1020
gcctatgcca tgttcatctc caactgtgcc gtttccacca acattgacat ctgcttccag 1080
gtcacccaga ccatcgcctt cttccacagt tgcctgaacc ctgttctcta tgtttttgtg 1140
ggtgagagat tccgccggga tctcgtgaaa accctgaaga acttgggttg catcagccag 1200
gcccagtggg tttcatttac aaggagagag ggaagcttga agctgtcgtc tatgttgctg 1260
gagacaacct caggagcact ctccctctga ggggtcttct ctgaggtgca tggttctttt 1320
ggaagaaatg agaaatacag aaacagtttc cccactgatg ggaccagaga gagtgaaaga 1380
gaaaagaaaa ctcagaaagg gatgaatctg aactatatga ttacttgtag tcagaatttg 1440
ccaaagcaaa tatttcaaaa tcaactgact agtgcaggag gctgttgatt ggctcttgac 1500
tgtgatgccc gcaattctca aaggaggact aaggaccggc actgtggagc accctggctt 1560
tgccactcgc cggagcatca atgccgctgc ctctggagga gcccttggat tttctccatg 1620
cactgtgaac ttctgtggct tcagttctca tgctgcctct tccaaaaggg gacacagaag 1680
cactggctgc tgctacagac cgcaaaagca gaaagtttcg tgaaaatgtc catctttggg 1740
aaattttcta ccctgctctt gagcctgata acccatgcca ggtcttatag attcctgatc 1800
tagaaccttt ccaggcaatc tcagacctaa tttccttctg ttctccttgt tctgttctgg 1860
gccagtgaag gtccttgttc tgattttgaa acgatctgca ggtcttgcca gtgaacccct 1920
ggacaactga ccacacccac aaggcatcca aagtctgttg gcttccaatc catttctgtg 1980
tcctgctgga ggttttaacc tagacaagga ttccgcttat tccttggtat ggtgacagtg 2040
tctctccatg gcctgagcag ggagattata acagctgggt tcgcaggagc cagccttggc 2100
cctgttgtag gcttgttctg ttgagtggca cttgctttgg gtccaccgtc tgtctgctcc 2160
ctagaaaatg ggctggttct tttggccctc ttctttctga ggcccacttt attctgagga 2220
atacagtgag cagatatggg cagcagccag gtagggcaaa ggggtgaagc gcaggccttg 2280
ctggaaggct atttacttcc atgcttctcc ttttcttact ctatagtggc aacattttaa 2340
aagcttttaa cttagagatt aggctgaaaa aaataagtaa tggaattcac ctttgcatct 2400
tttgtgtctt tcttatcatg atttggcaaa atgcatcacc tttgaaaata tttcacatat 2460
tggaaaagtg ctttttaatg tgtatatgaa gcattaatta cttgtcactt tctttaccct 2520
gtctcaatat tttaagtgtg tgcaattaaa gatcaaatag atacatt               2567

<210> 22
<211> 2653
<212> DNA
<213> Homo sapiens

<220> 
<223> Exemplary nucleic acid sequence encoding human CCR9,
GenBank Accession No. NM001256369.1

<400> 22
gcttcctttc tcgtgttgtt atcgggtagc tgcctgctca gaacccacaa agcctgcccc 60
tcatcccagg cagagagcaa cccagctctt tccccagaca ctgagagctg gtggtgcctg 120
ctgtcccagg gagagttgca tcgccctcca cagagcaggc ttgcatctga ctgacccacc 180
atgacaccca cagacttcac atctcctcca ggccccgctc cagatcacct tccctcgctg 240
gcccaggaat ccatctcctt ccaggacctt agcccaggac taacacaagc cctattccta 300
acatggctga tgactatggc tctgaatcca catcttccat ggaagactac gttaacttca 360
acttcactga cttctactgt gagaaaaaca atgtcaggca gtttgcgagc catttcctcc 420
cacccttgta ctggctcgtg ttcatcgtgg gtgccttggg caacagtctt gttatccttg 480
tctactggta ctgcacaaga gtgaagacca tgaccgacat gttccttttg aatttggcaa 540
ttgctgacct cctctttctt gtcactcttc ccttctgggc cattgctgct gctgaccagt 600
ggaagttcca gaccttcatg tgcaaggtgg tcaacagcat gtacaagatg aacttctaca 660
gctgtgtgtt gctgatcatg tgcatcagcg tggacaggta cattgccatt gcccaggcca 720
tgagagcaca tacttggagg gagaaaaggc ttttgtacag caaaatggtt tgctttacca 780
tctgggtatt ggcagctgct ctctgcatcc cagaaatctt atacagccaa atcaaggagg 840
aatccggcat tgctatctgc accatggttt accctagcga tgagagcacc aaactgaagt 900
cagctgtctt gaccctgaag gtcattctgg ggttcttcct tcccttcgtg gtcatggctt 960
gctgctatac catcatcatt cacaccctga tacaagccaa gaagtcttcc aagcacaaag 1020
ccctaaaagt gaccatcact gtcctgaccg tctttgtctt gtctcagttt ccctacaact 1080
gcattttgtt ggtgcagacc attgacgcct atgccatgtt catctccaac tgtgccgttt 1140
ccaccaacat tgacatctgc ttccaggtca cccagaccat cgccttcttc cacagttgcc 1200
tgaaccctgt tctctatgtt tttgtgggtg agagattccg ccgggatctc gtgaaaaccc 1260
tgaagaactt gggttgcatc agccaggccc agtgggtttc atttacaagg agagagggaa 1320
gcttgaagct gtcgtctatg ttgctggaga caacctcagg agcactctcc ctctgagggg 1380
tcttctctga ggtgcatggt tcttttggaa gaaatgagaa atacagaaac agtttcccca 1440
ctgatgggac cagagagagt gaaagagaaa agaaaactca gaaagggatg aatctgaact 1500
atatgattac ttgtagtcag aatttgccaa agcaaatatt tcaaaatcaa ctgactagtg 1560
caggaggctg ttgattggct cttgactgtg atgcccgcaa ttctcaaagg aggactaagg 1620
accggcactg tggagcaccc tggctttgcc actcgccgga gcatcaatgc cgctgcctct 1680
ggaggagccc ttggattttc tccatgcact gtgaacttct gtggcttcag ttctcatgct 1740
gcctcttcca aaaggggaca cagaagcact ggctgctgct acagaccgca aaagcagaaa 1800
gtttcgtgaa aatgtccatc tttgggaaat tttctaccct gctcttgagc ctgataaccc 1860
atgccaggtc ttatagattc ctgatctaga acctttccag gcaatctcag acctaatttc 1920
cttctgttct ccttgttctg ttctgggcca gtgaaggtcc ttgttctgat tttgaaacga 1980
tctgcaggtc ttgccagtga acccctggac aactgaccac acccacaagg catccaaagt 2040
ctgttggctt ccaatccatt tctgtgtcct gctggaggtt ttaacctaga caaggattcc 2100
gcttattcct tggtatggtg acagtgtctc tccatggcct gagcagggag attataacag 2160
ctgggttcgc aggagccagc cttggccctg ttgtaggctt gttctgttga gtggcacttg 2220
ctttgggtcc accgtctgtc tgctccctag aaaatgggct ggttcttttg gccctcttct 2280
ttctgaggcc cactttattc tgaggaatac agtgagcaga tatgggcagc agccaggtag 2340
ggcaaagggg tgaagcgcag gccttgctgg aaggctattt acttccatgc ttctcctttt 2400
cttactctat agtggcaaca ttttaaaagc ttttaactta gagattaggc tgaaaaaaat 2460
aagtaatgga attcaccttt gcatcttttg tgtctttctt atcatgattt ggcaaaatgc 2520
atcacctttg aaaatatttc acatattgga aaagtgcttt ttaatgtgta tatgaagcat 2580
taattacttg tcactttctt taccctgtct caatatttta agtgtgtgca attaaagatc 2640
aaatagatac att                                                    2653

<210> 23
<211> 369
<212> PRT
<213> Homo sapiens

<220> 
<223> Exemplary amino acid sequence of human CCR9 precursor,
GenBank Accession No. NP_112477.1

<400> 23
Met Thr Pro Thr Asp Phe Thr Ser Pro Ile Pro Asn Met Ala Asp Asp
 1               5                  10                  15      
Tyr Gly Ser Glu Ser Thr Ser Ser Met Glu Asp Tyr Val Asn Phe Asn
            20                  25                  30          
Phe Thr Asp Phe Tyr Cys Glu Lys Asn Asn Val Arg Gln Phe Ala Ser
        35                  40                  45              
His Phe Leu Pro Pro Leu Tyr Trp Leu Val Phe Ile Val Gly Ala Leu
    50                  55                  60                  
Gly Asn Ser Leu Val Ile Leu Val Tyr Trp Tyr Cys Thr Arg Val Lys
65                  70                  75                  80  
Thr Met Thr Asp Met Phe Leu Leu Asn Leu Ala Ile Ala Asp Leu Leu
                85                  90                  95      
Phe Leu Val Thr Leu Pro Phe Trp Ala Ile Ala Ala Ala Asp Gln Trp
            100                 105                 110         
Lys Phe Gln Thr Phe Met Cys Lys Val Val Asn Ser Met Tyr Lys Met
        115                 120                 125             
Asn Phe Tyr Ser Cys Val Leu Leu Ile Met Cys Ile Ser Val Asp Arg
    130                 135                 140                 
Tyr Ile Ala Ile Ala Gln Ala Met Arg Ala His Thr Trp Arg Glu Lys
145                 150                 155                 160 
Arg Leu Leu Tyr Ser Lys Met Val Cys Phe Thr Ile Trp Val Leu Ala
                165                 170                 175     
Ala Ala Leu Cys Ile Pro Glu Ile Leu Tyr Ser Gln Ile Lys Glu Glu
            180                 185                 190         
Ser Gly Ile Ala Ile Cys Thr Met Val Tyr Pro Ser Asp Glu Ser Thr
        195                 200                 205             
Lys Leu Lys Ser Ala Val Leu Thr Leu Lys Val Ile Leu Gly Phe Phe
    210                 215                 220                 
Leu Pro Phe Val Val Met Ala Cys Cys Tyr Thr Ile Ile Ile His Thr
225                 230                 235                 240 
Leu Ile Gln Ala Lys Lys Ser Ser Lys His Lys Ala Leu Lys Val Thr
                245                 250                 255     
Ile Thr Val Leu Thr Val Phe Val Leu Ser Gln Phe Pro Tyr Asn Cys
            260                 265                 270         
Ile Leu Leu Val Gln Thr Ile Asp Ala Tyr Ala Met Phe Ile Ser Asn
        275                 280                 285             
Cys Ala Val Ser Thr Asn Ile Asp Ile Cys Phe Gln Val Thr Gln Thr
    290                 295                 300                 
Ile Ala Phe Phe His Ser Cys Leu Asn Pro Val Leu Tyr Val Phe Val
305                 310                 315                 320 
Gly Glu Arg Phe Arg Arg Asp Leu Val Lys Thr Leu Lys Asn Leu Gly
                325                 330                 335     
Cys Ile Ser Gln Ala Gln Trp Val Ser Phe Thr Arg Arg Glu Gly Ser
            340                 345                 350         
Leu Lys Leu Ser Ser Met Leu Leu Glu Thr Thr Ser Gly Ala Leu Ser
        355                 360                 365             
Leu
    


<210> 24
<211> 357
<212> PRT
<213> Homo sapiens

<220> 
<223> Exemplary amino acid sequence of human CCR9 precursor,
GenBank Accession No. NP_001243298.1

<400> 24
Met Ala Asp Asp Tyr Gly Ser Glu Ser Thr Ser Ser Met Glu Asp Tyr
 1               5                  10                  15      
Val Asn Phe Asn Phe Thr Asp Phe Tyr Cys Glu Lys Asn Asn Val Arg
            20                  25                  30          
Gln Phe Ala Ser His Phe Leu Pro Pro Leu Tyr Trp Leu Val Phe Ile
        35                  40                  45              
Val Gly Ala Leu Gly Asn Ser Leu Val Ile Leu Val Tyr Trp Tyr Cys
    50                  55                  60                  
Thr Arg Val Lys Thr Met Thr Asp Met Phe Leu Leu Asn Leu Ala Ile
65                  70                  75                  80  
Ala Asp Leu Leu Phe Leu Val Thr Leu Pro Phe Trp Ala Ile Ala Ala
                85                  90                  95      
Ala Asp Gln Trp Lys Phe Gln Thr Phe Met Cys Lys Val Val Asn Ser
            100                 105                 110         
Met Tyr Lys Met Asn Phe Tyr Ser Cys Val Leu Leu Ile Met Cys Ile
        115                 120                 125             
Ser Val Asp Arg Tyr Ile Ala Ile Ala Gln Ala Met Arg Ala His Thr
    130                 135                 140                 
Trp Arg Glu Lys Arg Leu Leu Tyr Ser Lys Met Val Cys Phe Thr Ile
145                 150                 155                 160 
Trp Val Leu Ala Ala Ala Leu Cys Ile Pro Glu Ile Leu Tyr Ser Gln
                165                 170                 175     
Ile Lys Glu Glu Ser Gly Ile Ala Ile Cys Thr Met Val Tyr Pro Ser
            180                 185                 190         
Asp Glu Ser Thr Lys Leu Lys Ser Ala Val Leu Thr Leu Lys Val Ile
        195                 200                 205             
Leu Gly Phe Phe Leu Pro Phe Val Val Met Ala Cys Cys Tyr Thr Ile
    210                 215                 220                 
Ile Ile His Thr Leu Ile Gln Ala Lys Lys Ser Ser Lys His Lys Ala
225                 230                 235                 240 
Leu Lys Val Thr Ile Thr Val Leu Thr Val Phe Val Leu Ser Gln Phe
                245                 250                 255     
Pro Tyr Asn Cys Ile Leu Leu Val Gln Thr Ile Asp Ala Tyr Ala Met
            260                 265                 270         
Phe Ile Ser Asn Cys Ala Val Ser Thr Asn Ile Asp Ile Cys Phe Gln
        275                 280                 285             
Val Thr Gln Thr Ile Ala Phe Phe His Ser Cys Leu Asn Pro Val Leu
    290                 295                 300                 
Tyr Val Phe Val Gly Glu Arg Phe Arg Arg Asp Leu Val Lys Thr Leu
305                 310                 315                 320 
Lys Asn Leu Gly Cys Ile Ser Gln Ala Gln Trp Val Ser Phe Thr Arg
                325                 330                 335     
Arg Glu Gly Ser Leu Lys Leu Ser Ser Met Leu Leu Glu Thr Thr Ser
            340                 345                 350         
Gly Ala Leu Ser Leu
        355         


<210> 25
<211> 6082
<212> DNA
<213> Homo sapiens

<220> 
<223> Exemplary nucleic acid sequence encoding human alpha 4,
GenBank Accession No. NM_000885.4

<400> 25
ataacgtctt tgtcactaaa atgttcccca ggggccttcg gcgagtcttt ttgtttggtt 60
ttttgttttt aatctgtggc tcttgataat ttatctagtg gttgcctaca cctgaaaaac 120
aagacacagt gtttaactat caacgaaaga actggacggc tccccgccgc agtcccactc 180
cccgagtttg tggctggcat ttgggccacg ccgggctggg cggtcacagc gaggggcgcg 240
cagtttgggg tcacacagct ccgcttctag gccccaacca ccgttaaaag gggaagcccg 300
tgccccatca ggtccgctct tgctgagccc agagccatcc cgcgctctgc gggctgggag 360
gcccgggcca ggacgcgagt cctgcgcagc cgaggttccc cagcgccccc tgcagccgcg 420
cgtaggcaga gacggagccc ggccctgcgc ctccgcacca cgcccgggac cccacccagc 480
ggcccgtacc cggagaagca gcgcgagcac ccgaagctcc cggctggcgg cagaaaccgg 540
gagtggggcc gggcgagtgc gcggcatccc aggccggccc gaacgctccg cccgcggtgg 600
gccgacttcc cctcctcttc cctctctcct tcctttagcc cgctggcgcc ggacacgctg 660
cgcctcatct cttggggcgt tcttccccgt tggccaaccg tcgcatcccg tgcaactttg 720
gggtagtggc cgtttagtgt tgaatgttcc ccaccgagag cgcatggctt gggaagcgag 780
gcgcgaaccc ggcccccgaa gggccgccgt ccgggagacg gtgatgctgt tgctgtgcct 840
gggggtcccg accggccgcc cctacaacgt ggacactgag agcgcgctgc tttaccaggg 900
cccccacaac acgctgttcg gctactcggt cgtgctgcac agccacgggg cgaaccgatg 960
gctcctagtg ggtgcgccca ctgccaactg gctcgccaac gcttcagtga tcaatcccgg 1020
ggcgatttac agatgcagga tcggaaagaa tcccggccag acgtgcgaac agctccagct 1080
gggtagccct aatggagaac cttgtggaaa gacttgtttg gaagagagag acaatcagtg 1140
gttgggggtc acactttcca gacagccagg agaaaatgga tccatcgtga cttgtgggca 1200
tagatggaaa aatatatttt acataaagaa tgaaaataag ctccccactg gtggttgcta 1260
tggagtgccc cctgatttac gaacagaact gagtaaaaga atagctccgt gttatcaaga 1320
ttatgtgaaa aaatttggag aaaattttgc atcatgtcaa gctggaatat ccagttttta 1380
cacaaaggat ttaattgtga tgggggcccc aggatcatct tactggactg gctctctttt 1440
tgtctacaat ataactacaa ataaatacaa ggctttttta gacaaacaaa atcaagtaaa 1500
atttggaagt tatttaggat attcagtcgg agctggtcat tttcggagcc agcatactac 1560
cgaagtagtc ggaggagctc ctcaacatga gcagattggt aaggcatata tattcagcat 1620
tgatgaaaaa gaactaaata tcttacatga aatgaaaggt aaaaagcttg gatcgtactt 1680
tggagcttct gtctgtgctg tggacctcaa tgcagatggc ttctcagatc tgctcgtggg 1740
agcacccatg cagagcacca tcagagagga aggaagagtg tttgtgtaca tcaactctgg 1800
ctcgggagca gtaatgaatg caatggaaac aaacctcgtt ggaagtgaca aatatgctgc 1860
aagatttggg gaatctatag ttaatcttgg cgacattgac aatgatggct ttgaagatgt 1920
tgctatcgga gctccacaag aagatgactt gcaaggtgct atttatattt acaatggccg 1980
tgcagatggg atctcgtcaa ccttctcaca gagaattgaa ggacttcaga tcagcaaatc 2040
gttaagtatg tttggacagt ctatatcagg acaaattgat gcagataata atggctatgt 2100
agatgtagca gttggtgctt ttcggtctga ttctgctgtc ttgctaagga caagacctgt 2160
agtaattgtt gacgcttctt taagccaccc tgagtcagta aatagaacga aatttgactg 2220
tgttgaaaat ggatggcctt ctgtgtgcat agatctaaca ctttgtttct catataaggg 2280
caaggaagtt ccaggttaca ttgttttgtt ttataacatg agtttggatg tgaacagaaa 2340
ggcagagtct ccaccaagat tctatttctc ttctaatgga acttctgacg tgattacagg 2400
aagcatacag gtgtccagca gagaagctaa ctgtagaaca catcaagcat ttatgcggaa 2460
agatgtgcgg gacatcctca ccccaattca gattgaagct gcttaccacc ttggtcctca 2520
tgtcatcagt aaacgaagta cagaggaatt cccaccactt cagccaattc ttcagcagaa 2580
gaaagaaaaa gacataatga aaaaaacaat aaactttgca aggttttgtg cccatgaaaa 2640
ttgttctgct gatttacagg tttctgcaaa gattgggttt ttgaagcccc atgaaaataa 2700
aacatatctt gctgttggga gtatgaagac attgatgttg aatgtgtcct tgtttaatgc 2760
tggagatgat gcatatgaaa cgactctaca tgtcaaacta cccgtgggtc tttatttcat 2820
taagatttta gagctggaag agaagcaaat aaactgtgaa gtcacagata actctggcgt 2880
ggtacaactt gactgcagta ttggctatat atatgtagat catctctcaa ggatagatat 2940
tagctttctc ctggatgtga gctcactcag cagagcggaa gaggacctca gtatcacagt 3000
gcatgctacc tgtgaaaatg aagaggaaat ggacaatcta aagcacagca gagtgactgt 3060
agcaatacct ttaaaatatg aggttaagct gactgttcat gggtttgtaa acccaacttc 3120
atttgtgtat ggatcaaatg atgaaaatga gcctgaaacg tgcatggtgg agaaaatgaa 3180
cttaactttc catgttatca acactggcaa tagtatggct cccaatgtta gtgtggaaat 3240
aatggtacca aattctttta gcccccaaac tgataagctg ttcaacattt tggatgtcca 3300
gactactact ggagaatgcc actttgaaaa ttatcaaaga gtgtgtgcat tagagcagca 3360
aaagagtgca atgcagacct tgaaaggcat agtccggttc ttgtccaaga ctgataagag 3420
gctattgtac tgcataaaag ctgatccaca ttgtttaaat ttcttgtgta attttgggaa 3480
aatggaaagt ggaaaagaag ccagtgttca tatccaactg gaaggccggc catccatttt 3540
agaaatggat gagacttcag cactcaagtt tgaaataaga gcaacaggtt ttccagagcc 3600
aaatccaaga gtaattgaac taaacaagga tgagaatgtt gcgcatgttc tactggaagg 3660
actacatcat caaagaccca aacgttattt caccatagtg attatttcaa gtagcttgct 3720
acttggactt attgtacttc tgttgatctc atatgttatg tggaaggctg gcttctttaa 3780
aagacaatac aaatctatcc tacaagaaga aaacagaaga gacagttgga gttatatcaa 3840
cagtaaaagc aatgatgatt aaggacttct ttcaaattga gagaatggaa aacagactca 3900
ggttgtagta aagaaattta aaagacactg tttacaagaa aaaatgaatt ttgtttggac 3960
ttcttttact catgatcttg tgacatatta tgtcttcatg caaggggaaa atctcagcaa 4020
tgattactct ttgagataga agaactgcaa aggtaataat acagccaaag ataatctctc 4080
agcttttaaa tgggtagaga aacactaaag cattcaattt attcaagaaa agtaagccct 4140
tgaagatatc ttgaaatgaa agtataactg agttaaatta tactggagaa gtcttagact 4200
tgaaatacta cttaccatat gtgcttgcct cagtaaaatg aaccccactg ggtgggcaga 4260
ggttcatttc aaatacatct ttgatacttg ttcaaaatat gttctttaaa aatataattt 4320
tttagagagc tgttcccaaa ttttctaacg agtggaccat tatcacttta aagcccttta 4380
tttataatac atttcctacg ggctgtgttc caacaaccat tttttttcag cagactatga 4440
atattatagt attataggcc aaactggcaa acttcagact gaacatgtac actggtttga 4500
gcttagtgaa attacttctg gataattatt tttttataat tatggatttc accatctttc 4560
tttctgtata tatacatgtg tttttatgta ggtatatatt taccattctt cctatctatt 4620
cttcctataa cacaccttta tcaagcatac ccaggagtaa tcttcaaatc ttttgttata 4680
ttctgaaaca aaagattgtg agtgttgcac tttacctgat acacgctgat ttagaaaata 4740
cagaaaccat acctcactaa taactttaaa atcaaagctg tgcaaagact agggggccta 4800
tacttcatat gtattatgta ctatgtaaaa tattgactat cacacaacta tttccttgga 4860
tgtaattctt tgttaccctt tacaagtata agtgttacct tacatggaaa cgaagaaaca 4920
aaattcataa atttaaattc ataaatttag ctgaaagata ctgattcaat ttgtatacag 4980
tgaatataaa tgagacgaca gcaaaatttt catgaaatgt aaaatatttt tatagtttgt 5040
tcatactata tgaggttcta ttttaaatga ctttctggat tttaaaaaat ttctttaaat 5100
acaatcattt ttgtaatatt tattttatgc ttatgatcta gataattgca gaatatcatt 5160
ttatctgact ctgccttcat aagagagctg tggccgaatt ttgaacatct gttataggga 5220
gtgatcaaat tagaaggcaa tgtggaaaaa caattctggg aaagatttct ttatatgaag 5280
tccctgccac tagccagcca tcctaattga tgaaagttat ctgttcacag gcctgcagtg 5340
atggtgagga atgttctgag atttgcgaag gcatttgagt agtgaaatgt aagcacaaaa 5400
cctcctgaac ccagagtgtg tatacacagg aataaacttt atgacattta tgtattttta 5460
aaaaactttg tatcgttata aaaaggctag tcattctttc aggagaacat ctaggatcat 5520
agatgaaaaa tcaagccccg atttagaact gtcttctcca ggatggtctc taaggaaatt 5580
tacatttggt tctttcctac tcagaactac tcagaaacaa ctatatattt caggttatct 5640
gagcacagtg aaagcagagt actatggttg tccaacacag gcctctcaga tacaagggga 5700
acacaattac atattgggct agattttgcc cagttcaaaa tagtatttgt tatcaactta 5760
ctttgttact tgtatcatga attttaaaac cctaccactt taagaagaca gggatgggtt 5820
attctttttt ggcaggtagg ctatataact atgtgatttt gaaatttaac tgctctggat 5880
tagggagcag tgaatcaagg cagacttatg aaatctgtat tatatttgta acagaatata 5940
ggaaatttaa cataattgat gagctcaaat cctgaaaaat gaaagaatcc aaattatttc 6000
agaattatct aggttaaata ttgatgtatt atgatggttg caaagttttt ttgtgtgtcc 6060
aataaacaca ttgtaaaaaa aa                                          6082



<210> 26
<211> 2878
<212> DNA
<213> Homo sapiens

<220> 
<223> Exemplary nucleic acid sequence encoding human beta 7,
GenBank Accession No. NM_000889.2

<400> 26
aaatcttccc caccctgggg agtgtcactt cctcctctgc cgtctcccag atcagtacac 60
aaaggctgct gctgccgcca gaggaaggac tgctctgcac gcacctatgt ggaaactaaa 120
gcccagagag aaagtctgac ttgccccaca gccagtgagt gactgcagca gcaccagaat 180
ctggtctgtt tcctgtttgg ctcttctacc actacggctt gggatctcgg gcatggtggc 240
tttgccaatg gtccttgttt tgctgctggt cctgagcaga ggtgagagtg aattggacgc 300
caagatccca tccacagggg atgccacaga atggcggaat cctcacctgt ccatgctggg 360
gtcctgccag ccagccccct cctgccagaa gtgcatcctc tcacacccca gctgtgcatg 420
gtgcaagcaa ctgaacttca ccgcgtcggg agaggcggag gcgcggcgct gcgcccgacg 480
agaggagctg ctggctcgag gctgcccgct ggaggagctg gaggagcccc gcggccagca 540
ggaggtgctg caggaccagc cgctcagcca gggcgcccgc ggagagggtg ccacccagct 600
ggcgccgcag cgggtccggg tcacgctgcg gcctggggag ccccagcagc tccaggtccg 660
cttccttcgt gctgagggat acccggtgga cctgtactac cttatggacc tgagctactc 720
catgaaggac gacctggaac gcgtgcgcca gctcgggcac gctctgctgg tccggctgca 780
ggaagtcacc cattctgtgc gcattggttt tggttccttt gtggacaaaa cggtgctgcc 840
ctttgtgagc acagtaccct ccaaactgcg ccacccctgc cccacccggc tggagcgctg 900
ccagtcacca ttcagctttc accatgtgct gtccctgacg ggggacgcac aagccttcga 960
gcgggaggtg gggcgccaga gtgtgtccgg caatctggac tcgcctgaag gtggcttcga 1020
tgccattctg caggctgcac tctgccagga gcagattggc tggagaaatg tgtcccggct 1080
gctggtgttc acttcagacg acacattcca tacagctggg gacgggaagt tgggcggcat 1140
tttcatgccc agtgatgggc actgccactt ggacagcaat ggcctctaca gtcgcagcac 1200
agagtttgac tacccttctg tgggtcaggt agcccaggcc ctctctgcag caaatatcca 1260
gcccatcttt gctgtcacca gtgccgcact gcctgtctac caggagctga gtaaactgat 1320
tcctaagtct gcagttgggg agctgagtga ggactccagc aacgtggtac agctcatcat 1380
ggatgcttat aatagcctgt cttccaccgt gacccttgaa cactcttcac tccctcctgg 1440
ggtccacatt tcttacgaat cccagtgtga gggtcctgag aagagggagg gtaaggctga 1500
ggatcgagga cagtgcaacc acgtccgaat caaccagacg gtgactttct gggtttctct 1560
ccaagccacc cactgcctcc cagagcccca tctcctgagg ctccgggccc ttggcttctc 1620
agaggagctg attgtggagt tgcacacgct gtgtgactgt aattgcagtg acacccagcc 1680
ccaggctccc cactgcagtg atggccaggg acacctacaa tgtggtgtat gcagctgtgc 1740
ccctggccgc ctaggtcggc tctgtgagtg ctctgtggca gagctgtcct ccccagacct 1800
ggaatctggg tgccgggctc ccaatggcac agggcccctg tgcagtggaa agggtcactg 1860
tcaatgtgga cgctgcagct gcagtggaca gagctctggg catctgtgcg agtgtgacga 1920
tgccagctgt gagcgacatg agggcatcct ctgcggaggc tttggtcgct gccaatgtgg 1980
agtatgtcac tgtcatgcca accgcacggg cagagcatgc gaatgcagtg gggacatgga 2040
cagttgcatc agtcccgagg gagggctctg cagtgggcat ggacgctgca aatgcaaccg 2100
ctgccagtgc ttggacggct actatggtgc tctatgcgac caatgcccag gctgcaagac 2160
accatgcgag agacaccggg actgtgcaga gtgtggggcc ttcaggactg gcccactggc 2220
caccaactgc agtacagctt gtgcccatac caatgtgacc ctggccttgg cccctatctt 2280
ggatgatggc tggtgcaaag agcggaccct ggacaaccag ctgttcttct tcttggtgga 2340
ggatgacgcc agaggcacgg tcgtgctcag agtgagaccc caagaaaagg gagcagacca 2400
cacgcaggcc attgtgctgg gctgcgtagg gggcatcgtg gcagtggggc tggggctggt 2460
cctggcttac cggctctcgg tggaaatcta tgaccgccgg gaatacagtc gctttgagaa 2520
ggagcagcaa caactcaact ggaagcagga cagtaatcct ctctacaaaa gtgccatcac 2580
gaccaccatc aatcctcgct ttcaagaggc agacagtccc actctctgaa ggagggaggg 2640
acacttaccc aaggctcttc tccttggagg acagtgggaa ctggagggtg agaggaaggg 2700
tgggtctgta agaccttggt aggggactaa ttcactggcg aggtgcggcc accaccctac 2760
ttcattttca gagtgacacc caagagggct gcttcccatg cctgcaacct tgcatccatc 2820
tgggctaccc cacccaagta tacaataaag tcttacctca gaccacaaaa aaaaaaaa   2878

<210> 27
<211> 1032
<212> PRT
<213> Homo sapiens

<220> 
<223> Exemplary amino acid sequence for human alpha 4,
GenBank Accession No. NP_000876.3

<400> 27
Met Ala Trp Glu Ala Arg Arg Glu Pro Gly Pro Arg Arg Ala Ala Val
 1               5                  10                  15      
Arg Glu Thr Val Met Leu Leu Leu Cys Leu Gly Val Pro Thr Gly Arg
            20                  25                  30          
Pro Tyr Asn Val Asp Thr Glu Ser Ala Leu Leu Tyr Gln Gly Pro His
        35                  40                  45              
Asn Thr Leu Phe Gly Tyr Ser Val Val Leu His Ser His Gly Ala Asn
    50                  55                  60                  
Arg Trp Leu Leu Val Gly Ala Pro Thr Ala Asn Trp Leu Ala Asn Ala
65                  70                  75                  80  
Ser Val Ile Asn Pro Gly Ala Ile Tyr Arg Cys Arg Ile Gly Lys Asn
                85                  90                  95      
Pro Gly Gln Thr Cys Glu Gln Leu Gln Leu Gly Ser Pro Asn Gly Glu
            100                 105                 110         
Pro Cys Gly Lys Thr Cys Leu Glu Glu Arg Asp Asn Gln Trp Leu Gly
        115                 120                 125             
Val Thr Leu Ser Arg Gln Pro Gly Glu Asn Gly Ser Ile Val Thr Cys
    130                 135                 140                 
Gly His Arg Trp Lys Asn Ile Phe Tyr Ile Lys Asn Glu Asn Lys Leu
145                 150                 155                 160 
Pro Thr Gly Gly Cys Tyr Gly Val Pro Pro Asp Leu Arg Thr Glu Leu
                165                 170                 175     
Ser Lys Arg Ile Ala Pro Cys Tyr Gln Asp Tyr Val Lys Lys Phe Gly
            180                 185                 190         
Glu Asn Phe Ala Ser Cys Gln Ala Gly Ile Ser Ser Phe Tyr Thr Lys
        195                 200                 205             
Asp Leu Ile Val Met Gly Ala Pro Gly Ser Ser Tyr Trp Thr Gly Ser
    210                 215                 220                 
Leu Phe Val Tyr Asn Ile Thr Thr Asn Lys Tyr Lys Ala Phe Leu Asp
225                 230                 235                 240 
Lys Gln Asn Gln Val Lys Phe Gly Ser Tyr Leu Gly Tyr Ser Val Gly
                245                 250                 255     
Ala Gly His Phe Arg Ser Gln His Thr Thr Glu Val Val Gly Gly Ala
            260                 265                 270         
Pro Gln His Glu Gln Ile Gly Lys Ala Tyr Ile Phe Ser Ile Asp Glu
        275                 280                 285             
Lys Glu Leu Asn Ile Leu His Glu Met Lys Gly Lys Lys Leu Gly Ser
    290                 295                 300                 
Tyr Phe Gly Ala Ser Val Cys Ala Val Asp Leu Asn Ala Asp Gly Phe
305                 310                 315                 320 
Ser Asp Leu Leu Val Gly Ala Pro Met Gln Ser Thr Ile Arg Glu Glu
                325                 330                 335     
Gly Arg Val Phe Val Tyr Ile Asn Ser Gly Ser Gly Ala Val Met Asn
            340                 345                 350         
Ala Met Glu Thr Asn Leu Val Gly Ser Asp Lys Tyr Ala Ala Arg Phe
        355                 360                 365             
Gly Glu Ser Ile Val Asn Leu Gly Asp Ile Asp Asn Asp Gly Phe Glu
    370                 375                 380                 
Asp Val Ala Ile Gly Ala Pro Gln Glu Asp Asp Leu Gln Gly Ala Ile
385                 390                 395                 400 
Tyr Ile Tyr Asn Gly Arg Ala Asp Gly Ile Ser Ser Thr Phe Ser Gln
                405                 410                 415     
Arg Ile Glu Gly Leu Gln Ile Ser Lys Ser Leu Ser Met Phe Gly Gln
            420                 425                 430         
Ser Ile Ser Gly Gln Ile Asp Ala Asp Asn Asn Gly Tyr Val Asp Val
        435                 440                 445             
Ala Val Gly Ala Phe Arg Ser Asp Ser Ala Val Leu Leu Arg Thr Arg
    450                 455                 460                 
Pro Val Val Ile Val Asp Ala Ser Leu Ser His Pro Glu Ser Val Asn
465                 470                 475                 480 
Arg Thr Lys Phe Asp Cys Val Glu Asn Gly Trp Pro Ser Val Cys Ile
                485                 490                 495     
Asp Leu Thr Leu Cys Phe Ser Tyr Lys Gly Lys Glu Val Pro Gly Tyr
            500                 505                 510         
Ile Val Leu Phe Tyr Asn Met Ser Leu Asp Val Asn Arg Lys Ala Glu
        515                 520                 525             
Ser Pro Pro Arg Phe Tyr Phe Ser Ser Asn Gly Thr Ser Asp Val Ile
    530                 535                 540                 
Thr Gly Ser Ile Gln Val Ser Ser Arg Glu Ala Asn Cys Arg Thr His
545                 550                 555                 560 
Gln Ala Phe Met Arg Lys Asp Val Arg Asp Ile Leu Thr Pro Ile Gln
                565                 570                 575     
Ile Glu Ala Ala Tyr His Leu Gly Pro His Val Ile Ser Lys Arg Ser
            580                 585                 590         
Thr Glu Glu Phe Pro Pro Leu Gln Pro Ile Leu Gln Gln Lys Lys Glu
        595                 600                 605             
Lys Asp Ile Met Lys Lys Thr Ile Asn Phe Ala Arg Phe Cys Ala His
    610                 615                 620                 
Glu Asn Cys Ser Ala Asp Leu Gln Val Ser Ala Lys Ile Gly Phe Leu
625                 630                 635                 640 
Lys Pro His Glu Asn Lys Thr Tyr Leu Ala Val Gly Ser Met Lys Thr
                645                 650                 655     
Leu Met Leu Asn Val Ser Leu Phe Asn Ala Gly Asp Asp Ala Tyr Glu
            660                 665                 670         
Thr Thr Leu His Val Lys Leu Pro Val Gly Leu Tyr Phe Ile Lys Ile
        675                 680                 685             
Leu Glu Leu Glu Glu Lys Gln Ile Asn Cys Glu Val Thr Asp Asn Ser
    690                 695                 700                 
Gly Val Val Gln Leu Asp Cys Ser Ile Gly Tyr Ile Tyr Val Asp His
705                 710                 715                 720 
Leu Ser Arg Ile Asp Ile Ser Phe Leu Leu Asp Val Ser Ser Leu Ser
                725                 730                 735     
Arg Ala Glu Glu Asp Leu Ser Ile Thr Val His Ala Thr Cys Glu Asn
            740                 745                 750         
Glu Glu Glu Met Asp Asn Leu Lys His Ser Arg Val Thr Val Ala Ile
        755                 760                 765             
Pro Leu Lys Tyr Glu Val Lys Leu Thr Val His Gly Phe Val Asn Pro
    770                 775                 780                 
Thr Ser Phe Val Tyr Gly Ser Asn Asp Glu Asn Glu Pro Glu Thr Cys
785                 790                 795                 800 
Met Val Glu Lys Met Asn Leu Thr Phe His Val Ile Asn Thr Gly Asn
                805                 810                 815     
Ser Met Ala Pro Asn Val Ser Val Glu Ile Met Val Pro Asn Ser Phe
            820                 825                 830         
Ser Pro Gln Thr Asp Lys Leu Phe Asn Ile Leu Asp Val Gln Thr Thr
        835                 840                 845             
Thr Gly Glu Cys His Phe Glu Asn Tyr Gln Arg Val Cys Ala Leu Glu
    850                 855                 860                 
Gln Gln Lys Ser Ala Met Gln Thr Leu Lys Gly Ile Val Arg Phe Leu
865                 870                 875                 880 
Ser Lys Thr Asp Lys Arg Leu Leu Tyr Cys Ile Lys Ala Asp Pro His
                885                 890                 895     
Cys Leu Asn Phe Leu Cys Asn Phe Gly Lys Met Glu Ser Gly Lys Glu
            900                 905                 910         
Ala Ser Val His Ile Gln Leu Glu Gly Arg Pro Ser Ile Leu Glu Met
        915                 920                 925             
Asp Glu Thr Ser Ala Leu Lys Phe Glu Ile Arg Ala Thr Gly Phe Pro
    930                 935                 940                 
Glu Pro Asn Pro Arg Val Ile Glu Leu Asn Lys Asp Glu Asn Val Ala
945                 950                 955                 960 
His Val Leu Leu Glu Gly Leu His His Gln Arg Pro Lys Arg Tyr Phe
                965                 970                 975     
Thr Ile Val Ile Ile Ser Ser Ser Leu Leu Leu Gly Leu Ile Val Leu
            980                 985                 990         
Leu Leu Ile Ser Tyr Val Met Trp Lys Ala Gly Phe Phe Lys Arg Gln
        995                 1000                1005            
Tyr Lys Ser Ile Leu Gln Glu Glu Asn Arg Arg Asp Ser Trp Ser Tyr
    1010                1015                1020                
Ile Asn Ser Lys Ser Asn Asp Asp
1025                1030        


<210> 28
<211> 798
<212> PRT
<213> Homo sapiens

<220> 
<223> Exemplary amino acid sequence for human beta 7,
GenBank Accession No. NP_000880.1

<400> 28
Met Val Ala Leu Pro Met Val Leu Val Leu Leu Leu Val Leu Ser Arg
 1               5                  10                  15      
Gly Glu Ser Glu Leu Asp Ala Lys Ile Pro Ser Thr Gly Asp Ala Thr
            20                  25                  30          
Glu Trp Arg Asn Pro His Leu Ser Met Leu Gly Ser Cys Gln Pro Ala
        35                  40                  45              
Pro Ser Cys Gln Lys Cys Ile Leu Ser His Pro Ser Cys Ala Trp Cys
    50                  55                  60                  
Lys Gln Leu Asn Phe Thr Ala Ser Gly Glu Ala Glu Ala Arg Arg Cys
65                  70                  75                  80  
Ala Arg Arg Glu Glu Leu Leu Ala Arg Gly Cys Pro Leu Glu Glu Leu
                85                  90                  95      
Glu Glu Pro Arg Gly Gln Gln Glu Val Leu Gln Asp Gln Pro Leu Ser
            100                 105                 110         
Gln Gly Ala Arg Gly Glu Gly Ala Thr Gln Leu Ala Pro Gln Arg Val
        115                 120                 125             
Arg Val Thr Leu Arg Pro Gly Glu Pro Gln Gln Leu Gln Val Arg Phe
    130                 135                 140                 
Leu Arg Ala Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu
145                 150                 155                 160 
Ser Tyr Ser Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His
                165                 170                 175     
Ala Leu Leu Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly
            180                 185                 190         
Phe Gly Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Ser Thr Val
        195                 200                 205             
Pro Ser Lys Leu Arg His Pro Cys Pro Thr Arg Leu Glu Arg Cys Gln
    210                 215                 220                 
Ser Pro Phe Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln
225                 230                 235                 240 
Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp
                245                 250                 255     
Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Cys Gln
            260                 265                 270         
Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser
        275                 280                 285             
Asp Asp Thr Phe His Thr Ala Gly Asp Gly Lys Leu Gly Gly Ile Phe
    290                 295                 300                 
Met Pro Ser Asp Gly His Cys His Leu Asp Ser Asn Gly Leu Tyr Ser
305                 310                 315                 320 
Arg Ser Thr Glu Phe Asp Tyr Pro Ser Val Gly Gln Val Ala Gln Ala
                325                 330                 335     
Leu Ser Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala
            340                 345                 350         
Leu Pro Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val
        355                 360                 365             
Gly Glu Leu Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Met Asp
    370                 375                 380                 
Ala Tyr Asn Ser Leu Ser Ser Thr Val Thr Leu Glu His Ser Ser Leu
385                 390                 395                 400 
Pro Pro Gly Val His Ile Ser Tyr Glu Ser Gln Cys Glu Gly Pro Glu
                405                 410                 415     
Lys Arg Glu Gly Lys Ala Glu Asp Arg Gly Gln Cys Asn His Val Arg
            420                 425                 430         
Ile Asn Gln Thr Val Thr Phe Trp Val Ser Leu Gln Ala Thr His Cys
        435                 440                 445             
Leu Pro Glu Pro His Leu Leu Arg Leu Arg Ala Leu Gly Phe Ser Glu
    450                 455                 460                 
Glu Leu Ile Val Glu Leu His Thr Leu Cys Asp Cys Asn Cys Ser Asp
465                 470                 475                 480 
Thr Gln Pro Gln Ala Pro His Cys Ser Asp Gly Gln Gly His Leu Gln
                485                 490                 495     
Cys Gly Val Cys Ser Cys Ala Pro Gly Arg Leu Gly Arg Leu Cys Glu
            500                 505                 510         
Cys Ser Val Ala Glu Leu Ser Ser Pro Asp Leu Glu Ser Gly Cys Arg
        515                 520                 525             
Ala Pro Asn Gly Thr Gly Pro Leu Cys Ser Gly Lys Gly His Cys Gln
    530                 535                 540                 
Cys Gly Arg Cys Ser Cys Ser Gly Gln Ser Ser Gly His Leu Cys Glu
545                 550                 555                 560 
Cys Asp Asp Ala Ser Cys Glu Arg His Glu Gly Ile Leu Cys Gly Gly
                565                 570                 575     
Phe Gly Arg Cys Gln Cys Gly Val Cys His Cys His Ala Asn Arg Thr
            580                 585                 590         
Gly Arg Ala Cys Glu Cys Ser Gly Asp Met Asp Ser Cys Ile Ser Pro
        595                 600                 605             
Glu Gly Gly Leu Cys Ser Gly His Gly Arg Cys Lys Cys Asn Arg Cys
    610                 615                 620                 
Gln Cys Leu Asp Gly Tyr Tyr Gly Ala Leu Cys Asp Gln Cys Pro Gly
625                 630                 635                 640 
Cys Lys Thr Pro Cys Glu Arg His Arg Asp Cys Ala Glu Cys Gly Ala
                645                 650                 655     
Phe Arg Thr Gly Pro Leu Ala Thr Asn Cys Ser Thr Ala Cys Ala His
            660                 665                 670         
Thr Asn Val Thr Leu Ala Leu Ala Pro Ile Leu Asp Asp Gly Trp Cys
        675                 680                 685             
Lys Glu Arg Thr Leu Asp Asn Gln Leu Phe Phe Phe Leu Val Glu Asp
    690                 695                 700                 
Asp Ala Arg Gly Thr Val Val Leu Arg Val Arg Pro Gln Glu Lys Gly
705                 710                 715                 720 
Ala Asp His Thr Gln Ala Ile Val Leu Gly Cys Val Gly Gly Ile Val
                725                 730                 735     
Ala Val Gly Leu Gly Leu Val Leu Ala Tyr Arg Leu Ser Val Glu Ile
            740                 745                 750         
Tyr Asp Arg Arg Glu Tyr Ser Arg Phe Glu Lys Glu Gln Gln Gln Leu
        755                 760                 765             
Asn Trp Lys Gln Asp Ser Asn Pro Leu Tyr Lys Ser Ala Ile Thr Thr
    770                 775                 780                 
Thr Ile Asn Pro Arg Phe Gln Glu Ala Asp Ser Pro Thr Leu
785                 790                 795             


<210> 29
<211> 1244
<212> DNA
<213> Homo sapiens

<220> 
<223> Exemplary nucleic acid sequence encoding human CCR10,
GenBank Accession No. NM_016602.2

<400> 29
agagatgggg acggaggcca cagagcaggt ttcctggggc cattactctg gggatgaaga 60
ggacgcatac tcggctgagc cactgccgga gctttgctac aaggccgatg tccaggcctt 120
cagccgggcc ttccaaccca gtgtctccct gaccgtggct gcgctgggtc tggccggcaa 180
tggcctggtc ctggccaccc acctggcagc ccgacgcgca gcgcgctcgc ccacctctgc 240
ccacctgctc cagctggccc tggccgacct cttgctggcc ctgactctgc ccttcgcggc 300
agcaggggct cttcagggct ggagtctggg aagtgccacc tgccgcacca tctctggcct 360
ctactcggcc tccttccacg ccggcttcct cttcctggcc tgtatcagcg ccgaccgcta 420
cgtggccatc gcgcgagcgc tcccagccgg gccgcggccc tccactcccg gccgcgcaca 480
cttggtctcc gtcatcgtgt ggctgctgtc actgctcctg gcgctgcctg cgctgctctt 540
cagccaggat gggcagcggg aaggccaacg acgctgtcgc ctcatcttcc ccgagggcct 600
cacgcagacg gtgaaggggg cgagcgccgt ggcgcaggtg gccctgggct tcgcgctgcc 660
gctgggcgtc atggtagcct gctacgcgct tctgggccgc acgctgctgg ccgccagggg 720
gcccgagcgc cggcgtgcgc tgcgcgtcgt ggtggctctg gtggcggcct tcgtggtgct 780
gcagctgccc tacagcctcg ccctgctgct ggatactgcc gatctactgg ctgcgcgcga 840
gcggagctgc cctgccagca aacgcaagga tgtcgcactg ctggtgacca gcggcttggc 900
cctcgcccgc tgtggcctca atcccgttct ctacgccttc ctgggcctgc gcttccgcca 960
ggacctgcgg aggctgctac ggggtgggag ctgcccctca gggcctcaac cccgccgcgg 1020
ctgcccccgc cggccccgcc tttcttcctg ctcagctccc acggagaccc acagtctctc 1080
ctgggacaac tagggctgcg aatctagagg agggggcagg ctgagggtcg tgggaaaggg 1140
gagtaggtgg gggaacactg agaaagaggc agggacctaa agggactacc tctgtgcctt 1200
gccacattaa attgataaca tggaaatgag atgcaaccca acaa                  1244

<210> 30
<211> 1244
<212> DNA
<213> Homo sapiens

<220> 
<223> Exemplary nucleic acid sequence encoding human CCR10,
GenBank Accession No. AF215981.1

<400> 30
agagatgggg acggaggcca cagagcaggt ttcctggggc cattactctg gggatgaaga 60
ggacgcatac tcggctgagc cactgccgga gctttgctac aaggccgatg tccaggcctt 120
cagccgggcc ttccaaccca gtgtctccct gaccgtggct gcgctgggtc tggccggcaa 180
tggcctggtc ctggccaccc acctggcagc ccgacgcgca gcgcgctcgc ccacctctgc 240
ccacctgctc cagctggccc tggccgacct cttgctggcc ctgactctgc ccttcgcggc 300
agcaggggct cttcagggct ggagtctggg aagtgccacc tgccgcacca tctctggcct 360
ctactcggcc tccttccacg ccggcttcct cttcctggcc tgtatcagcg ccgaccgcta 420
cgtggccatc gcgcgagcgc tcccagccgg gccgcggccc tccactcccg gccgcgcaca 480
cttggtctcc gtcatcgtgt ggctgctgtc actgctcctg gcgctgcctg cgctgctctt 540
cagccaggat gggcagcggg aaggccaacg acgctgtcgc ctcatcttcc ccgagggcct 600
cacgcagacg gtgaaggggg cgagcgccgt ggcgcaggtg gccctgggct tcgcgctgcc 660
gctgggcgtc atggtagcct gctacgcgct tctgggccgc acgctgctgg ccgccagggg 720
gcccgagcgc cggcgtgcgc tgcgcgtcgt ggtggctctg gtggcggcct tcgtggtgct 780
gcagctgccc tacagcctcg ccctgctgct ggatactgcc gatctactgg ctgcgcgcga 840
gcggagctgc cctgccagca aacgcaagga tgtcgcactg ctggtgacca gcggcttggc 900
cctcgcccgc tgtggcctca atcccgttct ctacgccttc ctgggcctgc gcttccgcca 960
ggacctgcgg aggctgctac ggggtgggag ctcgccctca gggcctcaac cccgccgcgg 1020
ctgcccccgc cggccccgcc tttcttcctg ctcagctccc acggagaccc acagtctctc 1080
ctgggacaac tagggctgcg aatctagagg agggggcagg ctgagggtcg tgggaaaggg 1140
gagtaggtgg gggaacactg agaaagaggc agggacctaa agggactacc tctgtgcctt 1200
gccacattaa attgataaca tggaaatgaa aaaaaaaaaa aaaa                  1244

<210> 31
<211> 362
<212> PRT
<213> Homo sapiens

<220> 
<223> Exemplary amino acid sequence for human CCR10 precursor,
GenBank Accession No. NP_057686.2

<400> 31
Met Gly Thr Glu Ala Thr Glu Gln Val Ser Trp Gly His Tyr Ser Gly
 1               5                  10                  15      
Asp Glu Glu Asp Ala Tyr Ser Ala Glu Pro Leu Pro Glu Leu Cys Tyr
            20                  25                  30          
Lys Ala Asp Val Gln Ala Phe Ser Arg Ala Phe Gln Pro Ser Val Ser
        35                  40                  45              
Leu Thr Val Ala Ala Leu Gly Leu Ala Gly Asn Gly Leu Val Leu Ala
    50                  55                  60                  
Thr His Leu Ala Ala Arg Arg Ala Ala Arg Ser Pro Thr Ser Ala His
65                  70                  75                  80  
Leu Leu Gln Leu Ala Leu Ala Asp Leu Leu Leu Ala Leu Thr Leu Pro
                85                  90                  95      
Phe Ala Ala Ala Gly Ala Leu Gln Gly Trp Ser Leu Gly Ser Ala Thr
            100                 105                 110         
Cys Arg Thr Ile Ser Gly Leu Tyr Ser Ala Ser Phe His Ala Gly Phe
        115                 120                 125             
Leu Phe Leu Ala Cys Ile Ser Ala Asp Arg Tyr Val Ala Ile Ala Arg
    130                 135                 140                 
Ala Leu Pro Ala Gly Pro Arg Pro Ser Thr Pro Gly Arg Ala His Leu
145                 150                 155                 160 
Val Ser Val Ile Val Trp Leu Leu Ser Leu Leu Leu Ala Leu Pro Ala
                165                 170                 175     
Leu Leu Phe Ser Gln Asp Gly Gln Arg Glu Gly Gln Arg Arg Cys Arg
            180                 185                 190         
Leu Ile Phe Pro Glu Gly Leu Thr Gln Thr Val Lys Gly Ala Ser Ala
        195                 200                 205             
Val Ala Gln Val Ala Leu Gly Phe Ala Leu Pro Leu Gly Val Met Val
    210                 215                 220                 
Ala Cys Tyr Ala Leu Leu Gly Arg Thr Leu Leu Ala Ala Arg Gly Pro
225                 230                 235                 240 
Glu Arg Arg Arg Ala Leu Arg Val Val Val Ala Leu Val Ala Ala Phe
                245                 250                 255     
Val Val Leu Gln Leu Pro Tyr Ser Leu Ala Leu Leu Leu Asp Thr Ala
            260                 265                 270         
Asp Leu Leu Ala Ala Arg Glu Arg Ser Cys Pro Ala Ser Lys Arg Lys
        275                 280                 285             
Asp Val Ala Leu Leu Val Thr Ser Gly Leu Ala Leu Ala Arg Cys Gly
    290                 295                 300                 
Leu Asn Pro Val Leu Tyr Ala Phe Leu Gly Leu Arg Phe Arg Gln Asp
305                 310                 315                 320 
Leu Arg Arg Leu Leu Arg Gly Gly Ser Cys Pro Ser Gly Pro Gln Pro
                325                 330                 335     
Arg Arg Gly Cys Pro Arg Arg Pro Arg Leu Ser Ser Cys Ser Ala Pro
            340                 345                 350         
Thr Glu Thr His Ser Leu Ser Trp Asp Asn
        355                 360         


<210> 32
<211> 362
<212> PRT
<213> Homo sapiens

<220> 
<223> Exemplary amino acid sequence for human CCR10 precursor,
GenBank Accession No. P46092.3

<400> 32
Met Gly Thr Glu Ala Thr Glu Gln Val Ser Trp Gly His Tyr Ser Gly
 1               5                  10                  15      
Asp Glu Glu Asp Ala Tyr Ser Ala Glu Pro Leu Pro Glu Leu Cys Tyr
            20                  25                  30          
Lys Ala Asp Val Gln Ala Phe Ser Arg Ala Phe Gln Pro Ser Val Ser
        35                  40                  45              
Leu Thr Val Ala Ala Leu Gly Leu Ala Gly Asn Gly Leu Val Leu Ala
    50                  55                  60                  
Thr His Leu Ala Ala Arg Arg Ala Ala Arg Ser Pro Thr Ser Ala His
65                  70                  75                  80  
Leu Leu Gln Leu Ala Leu Ala Asp Leu Leu Leu Ala Leu Thr Leu Pro
                85                  90                  95      
Phe Ala Ala Ala Gly Ala Leu Gln Gly Trp Ser Leu Gly Ser Ala Thr
            100                 105                 110         
Cys Arg Thr Ile Ser Gly Leu Tyr Ser Ala Ser Phe His Ala Gly Phe
        115                 120                 125             
Leu Phe Leu Ala Cys Ile Ser Ala Asp Arg Tyr Val Ala Ile Ala Arg
    130                 135                 140                 
Ala Leu Pro Ala Gly Pro Arg Pro Ser Thr Pro Gly Arg Ala His Leu
145                 150                 155                 160 
Val Ser Val Ile Val Trp Leu Leu Ser Leu Leu Leu Ala Leu Pro Ala
                165                 170                 175     
Leu Leu Phe Ser Gln Asp Gly Gln Arg Glu Gly Gln Arg Arg Cys Arg
            180                 185                 190         
Leu Ile Phe Pro Glu Gly Leu Thr Gln Thr Val Lys Gly Ala Ser Ala
        195                 200                 205             
Val Ala Gln Val Ala Leu Gly Phe Ala Leu Pro Leu Gly Val Met Val
    210                 215                 220                 
Ala Cys Tyr Ala Leu Leu Gly Arg Thr Leu Leu Ala Ala Arg Gly Pro
225                 230                 235                 240 
Glu Arg Arg Arg Ala Leu Arg Val Val Val Ala Leu Val Ala Ala Phe
                245                 250                 255     
Val Val Leu Gln Leu Pro Tyr Ser Leu Ala Leu Leu Leu Asp Thr Ala
            260                 265                 270         
Asp Leu Leu Ala Ala Arg Glu Arg Ser Cys Pro Ala Ser Lys Arg Lys
        275                 280                 285             
Asp Val Ala Leu Leu Val Thr Ser Gly Leu Ala Leu Ala Arg Cys Gly
    290                 295                 300                 
Leu Asn Pro Val Leu Tyr Ala Phe Leu Gly Leu Arg Phe Arg Gln Asp
305                 310                 315                 320 
Leu Arg Arg Leu Leu Arg Gly Gly Ser Cys Pro Ser Gly Pro Gln Pro
                325                 330                 335     
Arg Arg Gly Cys Pro Arg Arg Pro Arg Leu Ser Ser Cys Ser Ala Pro
            340                 345                 350         
Thr Glu Thr His Ser Leu Ser Trp Asp Asn
        355                 360         


<210> 33
<211> 1487
<212> DNA
<213> Homo sapiens

<220> 
<223> Exemplary nucleic acid sequence encoding human CCR8,
GenBank Accession No. NM_005201.3

<400> 33
tttgtagtgg gaggatacct ccagagaggc tgctgctcat tgagctgcac tcacatgagg 60
atacagactt tgtgaagaag gaattggcaa cactgaaacc tccagaacaa aggctgtcac 120
taaggtcccg ctgccttgat ggattataca cttgacctca gtgtgacaac agtgaccgac 180
tactactacc ctgatatctt ctcaagcccc tgtgatgcgg aacttattca gacaaatggc 240
aagttgctcc ttgctgtctt ttattgcctc ctgtttgtat tcagtcttct gggaaacagc 300
ctggtcatcc tggtccttgt ggtctgcaag aagctgagga gcatcacaga tgtatacctc 360
ttgaacctgg ccctgtctga cctgcttttt gtcttctcct tcccctttca gacctactat 420
ctgctggacc agtgggtgtt tgggactgta atgtgcaaag tggtgtctgg cttttattac 480
attggcttct acagcagcat gtttttcatc accctcatga gtgtggacag gtacctggct 540
gttgtccatg ccgtgtatgc cctaaaggtg aggacgatca ggatgggcac aacgctgtgc 600
ctggcagtat ggctaaccgc cattatggct accatcccat tgctagtgtt ttaccaagtg 660
gcctctgaag atggtgttct acagtgttat tcattttaca atcaacagac tttgaagtgg 720
aagatcttca ccaacttcaa aatgaacatt ttaggcttgt tgatcccatt caccatcttt 780
atgttctgct acattaaaat cctgcaccag ctgaagaggt gtcaaaacca caacaagacc 840
aaggccatca ggttggtgct cattgtggtc attgcatctt tacttttctg ggtcccattc 900
aacgtggttc ttttcctcac ttccttgcac agtatgcaca tcttggatgg atgtagcata 960
agccaacagc tgacttatgc cacccatgtc acagaaatca tttcctttac tcactgctgt 1020
gtgaaccctg ttatctatgc ttttgttggg gagaagttca agaaacacct ctcagaaata 1080
tttcagaaaa gttgcagcca aatcttcaac tacctaggaa gacaaatgcc tagggagagc 1140
tgtgaaaagt catcatcctg ccagcagcac tcctcccgtt cctccagcgt agactacatt 1200
ttgtgaggat caatgaagac taaatataaa aaacattttc ttgaatggca tgctagtagc 1260
agtgagcaaa ggtgtgggtg tgaaaggttt ccaaaaaaag ttcagcatga aggatgccat 1320
atatgttgtt gccaacactt ggaacacaat gactaaagac atagttgtgc atgcctggca 1380
caacatcaag cctgtgattg tgtttattga tgatgttgaa caagtggtaa ctttaaagga 1440
ttctgtatgc caagtgaaaa aaaaagatgt ctgacctcct tacatat               1487

<210> 34
<211> 1420
<212> DNA
<213> Homo sapiens

<220> 
<223> Exemplary nucleic acid sequence encoding human CCR8,
GenBank Accession No. BC107159.1

<400> 34
ctttgtgaag aaggaattgg caacactgaa acctccagaa caaaggctgt cactaaggtc 60
ccgctgcctt gatggattat acacttgacc tcagtgtgac aacagtgacc gactactact 120
accctgatat cttctcaagc ccctgtgatg cggaacttat tcagacaaat ggcaagttgc 180
tccttgctgt cttttattgc ctcctgtttg tattcagtct tctgggaaac agcctggtca 240
tcctggtcct tgtggtctgc aagaagctga ggagcatcac agatgtatac ctcttgaacc 300
tggccctgtc tgacctgctt tttgtcttct ccttcccctt tcagacctac tatctgctgg 360
accagtgggt gtttgggact gtaatgtgca aagtggtgtc tggcttttat tacattggct 420
tctacagcag catgtttttc atcaccctca tgagtgtgga caggtacctg gctgttgtcc 480
atgccgtgta tgccctaaag gtgaggacga tcaggatggg cacaacgctg tgcctggcag 540
tatggctaac cgccattatg gctaccatcc cattgctagt gttttaccaa gtggcctctg 600
aagatggtgt tctacagtgt tattcatttt acaatcaaca gactttgaag tggaagatct 660
tcaccaactt caaaatgaac attttaggct tgttgatccc attcaccatc tttatgttct 720
gctacattaa aatcctgcac cagctgaaga ggtgtcaaaa ccacaacaag accaaggcca 780
tcaggttggt gctcattgtg gtcattgcat ctttactttt ctgggtccca ttcaacgtgg 840
ttcttttcct cacttccttg cacagtatgc acatcttgga tggatgtagc ataagccaac 900
agctgactta tgccacccat gtcacagaaa tcatttcctt tactcactgc tgtgtgaacc 960
ctgttatcta tgcttttgtt ggggagaagt tcaagaaaca cctctcagaa atatttcaga 1020
aaagttgcag ccaaatcttc aactacctag gaagacaaat gcctagggag agctgtgaaa 1080
agtcatcatc ctgccagcag cactcctccc gttcctccag cgtagactac attttgtgag 1140
gatcaatgaa gactaaatat aaaaaacatt ttcttgaatg gcatgctagt agcagtgagc 1200
aaaggtgtgg gtgtgaaagg tttccaaaaa aagttcagca tgaaggatgc cgtgtgtgtt 1260
gttgccaaca cttggaacac gatgactggg gacgtggttg tgcatgcctg gcacaacatc 1320
aagcctgtga ttgtgtttat tgatgatgtt gaacaagtgg tggctttgga ggattctgta 1380
tgccaagtga aaggggagat gtctgacctc cttcatatag                       1420

<210> 35
<211> 355
<212> PRT
<213> Homo sapiens

<220> 
<223> Exemplary amino acid sequence for human CCR8 precursor,
GenBank Accession No. NP_005192.1

<400> 35
Met Asp Tyr Thr Leu Asp Leu Ser Val Thr Thr Val Thr Asp Tyr Tyr
 1               5                  10                  15      
Tyr Pro Asp Ile Phe Ser Ser Pro Cys Asp Ala Glu Leu Ile Gln Thr
            20                  25                  30          
Asn Gly Lys Leu Leu Leu Ala Val Phe Tyr Cys Leu Leu Phe Val Phe
        35                  40                  45              
Ser Leu Leu Gly Asn Ser Leu Val Ile Leu Val Leu Val Val Cys Lys
    50                  55                  60                  
Lys Leu Arg Ser Ile Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ser
65                  70                  75                  80  
Asp Leu Leu Phe Val Phe Ser Phe Pro Phe Gln Thr Tyr Tyr Leu Leu
                85                  90                  95      
Asp Gln Trp Val Phe Gly Thr Val Met Cys Lys Val Val Ser Gly Phe
            100                 105                 110         
Tyr Tyr Ile Gly Phe Tyr Ser Ser Met Phe Phe Ile Thr Leu Met Ser
        115                 120                 125             
Val Asp Arg Tyr Leu Ala Val Val His Ala Val Tyr Ala Leu Lys Val
    130                 135                 140                 
Arg Thr Ile Arg Met Gly Thr Thr Leu Cys Leu Ala Val Trp Leu Thr
145                 150                 155                 160 
Ala Ile Met Ala Thr Ile Pro Leu Leu Val Phe Tyr Gln Val Ala Ser
                165                 170                 175     
Glu Asp Gly Val Leu Gln Cys Tyr Ser Phe Tyr Asn Gln Gln Thr Leu
            180                 185                 190         
Lys Trp Lys Ile Phe Thr Asn Phe Lys Met Asn Ile Leu Gly Leu Leu
        195                 200                 205             
Ile Pro Phe Thr Ile Phe Met Phe Cys Tyr Ile Lys Ile Leu His Gln
    210                 215                 220                 
Leu Lys Arg Cys Gln Asn His Asn Lys Thr Lys Ala Ile Arg Leu Val
225                 230                 235                 240 
Leu Ile Val Val Ile Ala Ser Leu Leu Phe Trp Val Pro Phe Asn Val
                245                 250                 255     
Val Leu Phe Leu Thr Ser Leu His Ser Met His Ile Leu Asp Gly Cys
            260                 265                 270         
Ser Ile Ser Gln Gln Leu Thr Tyr Ala Thr His Val Thr Glu Ile Ile
        275                 280                 285             
Ser Phe Thr His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Val Gly
    290                 295                 300                 
Glu Lys Phe Lys Lys His Leu Ser Glu Ile Phe Gln Lys Ser Cys Ser
305                 310                 315                 320 
Gln Ile Phe Asn Tyr Leu Gly Arg Gln Met Pro Arg Glu Ser Cys Glu
                325                 330                 335     
Lys Ser Ser Ser Cys Gln Gln His Ser Ser Arg Ser Ser Ser Val Asp
            340                 345                 350         
Tyr Ile Leu
        355 


<210> 36
<211> 355
<212> PRT
<213> Homo sapiens

<220> 
<223> Exemplary amino acid sequence for human CCR8 precursor,
GenBank Accession No. AAI07160.1

<400> 36
Met Asp Tyr Thr Leu Asp Leu Ser Val Thr Thr Val Thr Asp Tyr Tyr
 1               5                  10                  15      
Tyr Pro Asp Ile Phe Ser Ser Pro Cys Asp Ala Glu Leu Ile Gln Thr
            20                  25                  30          
Asn Gly Lys Leu Leu Leu Ala Val Phe Tyr Cys Leu Leu Phe Val Phe
        35                  40                  45              
Ser Leu Leu Gly Asn Ser Leu Val Ile Leu Val Leu Val Val Cys Lys
    50                  55                  60                  
Lys Leu Arg Ser Ile Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ser
65                  70                  75                  80  
Asp Leu Leu Phe Val Phe Ser Phe Pro Phe Gln Thr Tyr Tyr Leu Leu
                85                  90                  95      
Asp Gln Trp Val Phe Gly Thr Val Met Cys Lys Val Val Ser Gly Phe
            100                 105                 110         
Tyr Tyr Ile Gly Phe Tyr Ser Ser Met Phe Phe Ile Thr Leu Met Ser
        115                 120                 125             
Val Asp Arg Tyr Leu Ala Val Val His Ala Val Tyr Ala Leu Lys Val
    130                 135                 140                 
Arg Thr Ile Arg Met Gly Thr Thr Leu Cys Leu Ala Val Trp Leu Thr
145                 150                 155                 160 
Ala Ile Met Ala Thr Ile Pro Leu Leu Val Phe Tyr Gln Val Ala Ser
                165                 170                 175     
Glu Asp Gly Val Leu Gln Cys Tyr Ser Phe Tyr Asn Gln Gln Thr Leu
            180                 185                 190         
Lys Trp Lys Ile Phe Thr Asn Phe Lys Met Asn Ile Leu Gly Leu Leu
        195                 200                 205             
Ile Pro Phe Thr Ile Phe Met Phe Cys Tyr Ile Lys Ile Leu His Gln
    210                 215                 220                 
Leu Lys Arg Cys Gln Asn His Asn Lys Thr Lys Ala Ile Arg Leu Val
225                 230                 235                 240 
Leu Ile Val Val Ile Ala Ser Leu Leu Phe Trp Val Pro Phe Asn Val
                245                 250                 255     
Val Leu Phe Leu Thr Ser Leu His Ser Met His Ile Leu Asp Gly Cys
            260                 265                 270         
Ser Ile Ser Gln Gln Leu Thr Tyr Ala Thr His Val Thr Glu Ile Ile
        275                 280                 285             
Ser Phe Thr His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Val Gly
    290                 295                 300                 
Glu Lys Phe Lys Lys His Leu Ser Glu Ile Phe Gln Lys Ser Cys Ser
305                 310                 315                 320 
Gln Ile Phe Asn Tyr Leu Gly Arg Gln Met Pro Arg Glu Ser Cys Glu
                325                 330                 335     
Lys Ser Ser Ser Cys Gln Gln His Ser Ser Arg Ser Ser Ser Val Asp
            340                 345                 350         
Tyr Ile Leu
        355 


<210> 37
<211> 1657
<212> DNA
<213> Homo sapiens

<220> 
<223> Exemplary nucleic acid sequence encoding human CCR4,
GenBank Accession No. NM_005508.4

<400> 37
gctcacagga agccacgcac ccttgaaagg caccgggtcc ttcttagcat cgtgcttcct 60
gagcaagcct ggcattgcct cacagacctt cctcagagcc gctttcagaa aagcaagctg 120
cttctggttg ggcccagacc tgccttgagg agcctgtaga gttaaaaaat gaaccccacg 180
gatatagcag acaccaccct cgatgaaagc atatacagca attactatct gtatgaaagt 240
atccccaagc cttgcaccaa agaaggcatc aaggcatttg gggagctctt cctgccccca 300
ctgtattcct tggtttttgt atttggtctg cttggaaatt ctgtggtggt tctggtcctg 360
ttcaaataca agcggctcag gtccatgact gatgtgtacc tgctcaacct tgccatctcg 420
gatctgctct tcgtgttttc cctccctttt tggggctact atgcagcaga ccagtgggtt 480
tttgggctag gtctgtgcaa gatgatttcc tggatgtact tggtgggctt ttacagtggc 540
atattctttg tcatgctcat gagcattgat agatacctgg caattgtgca cgcggtgttt 600
tccttgaggg caaggacctt gacttatggg gtcatcacca gtttggctac atggtcagtg 660
gctgtgttcg cctcccttcc tggctttctg ttcagcactt gttatactga gcgcaaccat 720
acctactgca aaaccaagta ctctctcaac tccacgacgt ggaaggttct cagctccctg 780
gaaatcaaca ttctcggatt ggtgatcccc ttagggatca tgctgttttg ctactccatg 840
atcatcagga ccttgcagca ttgtaaaaat gagaagaaga acaaggcggt gaagatgatc 900
tttgccgtgg tggtcctctt ccttgggttc tggacacctt acaacatagt gctcttccta 960
gagaccctgg tggagctaga agtccttcag gactgcacct ttgaaagata cttggactat 1020
gccatccagg ccacagaaac tctggctttt gttcactgct gccttaatcc catcatctac 1080
ttttttctgg gggagaaatt tcgcaagtac atcctacagc tcttcaaaac ctgcaggggc 1140
ctttttgtgc tctgccaata ctgtgggctc ctccaaattt actctgctga cacccccagc 1200
tcatcttaca cgcagtccac catggatcat gatctccatg atgctctgta gaaaaatgaa 1260
atggtgaaat gcagagtcaa tgaactttcc acattcagag cttacttaaa attgtatttt 1320
agtaagagat tcctgagcca gtgtcaggag gaaggcttac acccacagtg gaaagacagc 1380
ttctcatcct gcaggcagct ttttctctcc cactagacaa gtccagcctg gcaagggttc 1440
acctgggctg aggcatcctt cctcacacca ggcttgcctg caggcatgag tcagtctgat 1500
gagaactctg agcagtgctt gaatgaagtt gtaggtaata ttgcaaggca aagactattc 1560
ccttctaacc tgaactgatg ggtttctcca gagggaattg cagagtactg gctgatggag 1620
taaatcgcta ccttttgctg tggcaaatgg gccctct                          1657

<210> 38
<211> 360
<212> PRT
<213> Homo sapiens

<220> 
<223> Exemplary amino acid sequence for human CCR4 precursor,
GenBank Accession No. P51679.1

<400> 38
Met Asn Pro Thr Asp Ile Ala Asp Thr Thr Leu Asp Glu Ser Ile Tyr
 1               5                  10                  15      
Ser Asn Tyr Tyr Leu Tyr Glu Ser Ile Pro Lys Pro Cys Thr Lys Glu
            20                  25                  30          
Gly Ile Lys Ala Phe Gly Glu Leu Phe Leu Pro Pro Leu Tyr Ser Leu
        35                  40                  45              
Val Phe Val Phe Gly Leu Leu Gly Asn Ser Val Val Val Leu Val Leu
    50                  55                  60                  
Phe Lys Tyr Lys Arg Leu Arg Ser Met Thr Asp Val Tyr Leu Leu Asn
65                  70                  75                  80  
Leu Ala Ile Ser Asp Leu Leu Phe Val Phe Ser Leu Pro Phe Trp Gly
                85                  90                  95      
Tyr Tyr Ala Ala Asp Gln Trp Val Phe Gly Leu Gly Leu Cys Lys Met
            100                 105                 110         
Ile Ser Trp Met Tyr Leu Val Gly Phe Tyr Ser Gly Ile Phe Phe Val
        115                 120                 125             
Met Leu Met Ser Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe
    130                 135                 140                 
Ser Leu Arg Ala Arg Thr Leu Thr Tyr Gly Val Ile Thr Ser Leu Ala
145                 150                 155                 160 
Thr Trp Ser Val Ala Val Phe Ala Ser Leu Pro Gly Phe Leu Phe Ser
                165                 170                 175     
Thr Cys Tyr Thr Glu Arg Asn His Thr Tyr Cys Lys Thr Lys Tyr Ser
            180                 185                 190         
Leu Asn Ser Thr Thr Trp Lys Val Leu Ser Ser Leu Glu Ile Asn Ile
        195                 200                 205             
Leu Gly Leu Val Ile Pro Leu Gly Ile Met Leu Phe Cys Tyr Ser Met
    210                 215                 220                 
Ile Ile Arg Thr Leu Gln His Cys Lys Asn Glu Lys Lys Asn Lys Ala
225                 230                 235                 240 
Val Lys Met Ile Phe Ala Val Val Val Leu Phe Leu Gly Phe Trp Thr
                245                 250                 255     
Pro Tyr Asn Ile Val Leu Phe Leu Glu Thr Leu Val Glu Leu Glu Val
            260                 265                 270         
Leu Gln Asp Cys Thr Phe Glu Arg Tyr Leu Asp Tyr Ala Ile Gln Ala
        275                 280                 285             
Thr Glu Thr Leu Ala Phe Val His Cys Cys Leu Asn Pro Ile Ile Tyr
    290                 295                 300                 
Phe Phe Leu Gly Glu Lys Phe Arg Lys Tyr Ile Leu Gln Leu Phe Lys
305                 310                 315                 320 
Thr Cys Arg Gly Leu Phe Val Leu Cys Gln Tyr Cys Gly Leu Leu Gln
                325                 330                 335     
Ile Tyr Ser Ala Asp Thr Pro Ser Ser Ser Tyr Thr Gln Ser Thr Met
            340                 345                 350         
Asp His Asp Leu His Asp Ala Leu
        355                 360 


<210> 39
<211> 2638
<212> DNA
<213> Homo sapiens

<220> 
<223> Exemplary nucleic acid sequence encoding human CLA,
GenBank Accession No. NM_001206609.1

<400> 39
aatcatccga gaaccttgga gggtggacag tgcccctttt acagatgaga aaactgaggc 60
ttgaagggga gaagcagctg cctctggcgg catggcttct ggctgcagga tgcccatgga 120
gttcgtggtg accctaggcc tgtgtctcgg cttcctttgc tgaacttgaa caggaagatg 180
gcagtggggg ccagtggtct agaaggagat aagatggctg gtgccatgcc tctgcaactc 240
ctcctgttgc tgatcctact gggccctggc aacagcttgc agctgtggga cacctgggca 300
gatgaagccg agaaagcctt gggtcccctg cttgcccggg accggagaca ggccaccgaa 360
tatgagtacc tagattatga tttcctgcca gaaacggagc ctccagaaat gctgaggaac 420
agcactgaca ccactcctct gactgggcct ggaacccctg agtctaccac tgtggagcct 480
gctgcaaggc gttctactgg cctggatgca ggaggggcag tcacagagct gaccacggag 540
ctggccaaca tggggaacct gtccacggat tcagcagcta tggagataca gaccactcaa 600
ccagcagcca cggaggcaca gaccactcaa ccagtgccca cggaggcaca gaccactcca 660
ctggcagcca cagaggcaca gacaactcga ctgacggcca cggaggcaca gaccactcca 720
ctggcagcca cagaggcaca gaccactcca ccagcagcca cggaagcaca gaccactcaa 780
cccacaggcc tggaggcaca gaccactgca ccagcagcca tggaggcaca gaccactgca 840
ccagcagcca tggaagcaca gaccactcca ccagcagcca tggaggcaca gaccactcaa 900
accacagcca tggaggcaca gaccactgca ccagaagcca cggaggcaca gaccactcaa 960
cccacagcca cggaggcaca gaccactcca ctggcagcca tggaggccct gtccacagaa 1020
cccagtgcca cagaggccct gtccatggaa cctactacca aaagaggtct gttcataccc 1080
ttttctgtgt cctctgttac tcacaagggc attcccatgg cagccagcaa tttgtccgtc 1140
aactacccag tgggggcccc agaccacatc tctgtgaagc agtgcctgct ggccatccta 1200
atcttggcgc tggtggccac tatcttcttc gtgtgcactg tggtgctggc ggtccgcctc 1260
tcccgcaagg gccacatgta ccccgtgcgt aattactccc ccaccgagat ggtctgcatc 1320
tcatccctgt tgcctgatgg gggtgagggg ccctctgcca cagccaatgg gggcctgtcc 1380
aaggccaaga gcccgggcct gacgccagag cccagggagg accgtgaggg ggatgacctc 1440
accctgcaca gcttcctccc ttagctcact ctgccatctg ttttggcaag accccacctc 1500
cacgggctct cctgggccac ccctgagtgc ccagacccca ttccacagct ctgggcttcc 1560
tcggagaccc ctggggatgg ggatcttcag ggaaggaact ctggccaccc aaacaggaca 1620
agagcagcct ggggccaagc agacgggcaa gtggagccac ctctttcctc cctccgcgga 1680
tgaagcccag ccacatttca gccgaggtcc aaggcaggag gccatttact tgagacagat 1740
tctctccttt ttcctgtccc ccatcttctc tgggtccctc taacatctcc catggctctc 1800
cccgcttctc ctggtcactg gagtctcctc cccatgtacc caaggaagat ggagctcccc 1860
catcccacac gcactgcact gccattgtct tttggttgcc atggtcacca aacaggaagt 1920
ggacattcta agggaggagt actgaagagt gacggacttc tgaggctgtt tcctgctgct 1980
cctctgactt ggggcagctt gggtcttctt gggcacctct ctgggaaaac ccagggtgag 2040
gttcagcctg tgagggctgg gatgggtttc gtgggcccaa gggcagacct ttctttggga 2100
ctgtgtggac caaggagctt ccatctagtg acaagtgacc cccagctatc gcctcttgcc 2160
ttcccctgtg gccactttcc agggtggact ctgtcttgtt cactgcagta tcccaactgc 2220
aggtccagtg caggcaataa atatgtgatg gacaaacgat agcggaatcc ttcaaggttt 2280
caaggctgtc tccttcaggc agccttcccg gaattctcca tccctcagtg caggatgggg 2340
gctggtcctc agctgtctgc cctcagcccc tggcccccca ggaagcctct ttcatgggct 2400
gttaggttga cttcagtttt gcctcttgga caacaggggg tcttgtacat ccttgggtga 2460
ccaggaaaag ttcaggctat ggggggccaa agggagggct gccccttccc caccagtgac 2520
cactttattc cacttcctcc attacccagt tttggcccac agagtttggt cccccccaaa 2580
cctcggacca atatccctct aaacatcaat ctatcctcct gttaaagaaa aaaaaaaa   2638

<210> 40
<211> 2573
<212> DNA
<213> Homo sapiens

<220> 
<223> Exemplary nucleic acid sequence encoding human CLA,
GenBank Accession No. NM_003006.4

<400> 40
acacacagcc attgggggtt gctcggatcc gggactgccg cagggggtgc cacagcagtg 60
cctggcagcg tgggctggga ccttgtcact aaagcagaga agccacttct tctgggccca 120
cgaggcagct gtcccatgct ctgctgagca cggtggtgcc atgcctctgc aactcctcct 180
gttgctgatc ctactgggcc ctggcaacag cttgcagctg tgggacacct gggcagatga 240
agccgagaaa gccttgggtc ccctgcttgc ccgggaccgg agacaggcca ccgaatatga 300
gtacctagat tatgatttcc tgccagaaac ggagcctcca gaaatgctga ggaacagcac 360
tgacaccact cctctgactg ggcctggaac ccctgagtct accactgtgg agcctgctgc 420
aaggcgttct actggcctgg atgcaggagg ggcagtcaca gagctgacca cggagctggc 480
caacatgggg aacctgtcca cggattcagc agctatggag atacagacca ctcaaccagc 540
agccacggag gcacagacca ctcaaccagt gcccacggag gcacagacca ctccactggc 600
agccacagag gcacagacaa ctcgactgac ggccacggag gcacagacca ctccactggc 660
agccacagag gcacagacca ctccaccagc agccacggaa gcacagacca ctcaacccac 720
aggcctggag gcacagacca ctgcaccagc agccatggag gcacagacca ctgcaccagc 780
agccatggaa gcacagacca ctccaccagc agccatggag gcacagacca ctcaaaccac 840
agccatggag gcacagacca ctgcaccaga agccacggag gcacagacca ctcaacccac 900
agccacggag gcacagacca ctccactggc agccatggag gccctgtcca cagaacccag 960
tgccacagag gccctgtcca tggaacctac taccaaaaga ggtctgttca tacccttttc 1020
tgtgtcctct gttactcaca agggcattcc catggcagcc agcaatttgt ccgtcaacta 1080
cccagtgggg gccccagacc acatctctgt gaagcagtgc ctgctggcca tcctaatctt 1140
ggcgctggtg gccactatct tcttcgtgtg cactgtggtg ctggcggtcc gcctctcccg 1200
caagggccac atgtaccccg tgcgtaatta ctcccccacc gagatggtct gcatctcatc 1260
cctgttgcct gatgggggtg aggggccctc tgccacagcc aatgggggcc tgtccaaggc 1320
caagagcccg ggcctgacgc cagagcccag ggaggaccgt gagggggatg acctcaccct 1380
gcacagcttc ctcccttagc tcactctgcc atctgttttg gcaagacccc acctccacgg 1440
gctctcctgg gccacccctg agtgcccaga ccccattcca cagctctggg cttcctcgga 1500
gacccctggg gatggggatc ttcagggaag gaactctggc cacccaaaca ggacaagagc 1560
agcctggggc caagcagacg ggcaagtgga gccacctctt tcctccctcc gcggatgaag 1620
cccagccaca tttcagccga ggtccaaggc aggaggccat ttacttgaga cagattctct 1680
cctttttcct gtcccccatc ttctctgggt ccctctaaca tctcccatgg ctctccccgc 1740
ttctcctggt cactggagtc tcctccccat gtacccaagg aagatggagc tcccccatcc 1800
cacacgcact gcactgccat tgtcttttgg ttgccatggt caccaaacag gaagtggaca 1860
ttctaaggga ggagtactga agagtgacgg acttctgagg ctgtttcctg ctgctcctct 1920
gacttggggc agcttgggtc ttcttgggca cctctctggg aaaacccagg gtgaggttca 1980
gcctgtgagg gctgggatgg gtttcgtggg cccaagggca gacctttctt tgggactgtg 2040
tggaccaagg agcttccatc tagtgacaag tgacccccag ctatcgcctc ttgccttccc 2100
ctgtggccac tttccagggt ggactctgtc ttgttcactg cagtatccca actgcaggtc 2160
cagtgcaggc aataaatatg tgatggacaa acgatagcgg aatccttcaa ggtttcaagg 2220
ctgtctcctt caggcagcct tcccggaatt ctccatccct cagtgcagga tgggggctgg 2280
tcctcagctg tctgccctca gcccctggcc ccccaggaag cctctttcat gggctgttag 2340
gttgacttca gttttgcctc ttggacaaca gggggtcttg tacatccttg ggtgaccagg 2400
aaaagttcag gctatggggg gccaaaggga gggctgcccc ttccccacca gtgaccactt 2460
tattccactt cctccattac ccagttttgg cccacagagt ttggtccccc ccaaacctcg 2520
gaccaatatc cctctaaaca tcaatctatc ctcctgttaa agaaaaaaaa aaa        2573

<210> 41
<211> 428
<212> PRT
<213> Homo sapiens

<220> 
<223> Exemplary amino acid sequence for human CLA precursor,
GenBank Accession No. NP_001193538.1

<400> 41
Met Ala Val Gly Ala Ser Gly Leu Glu Gly Asp Lys Met Ala Gly Ala
 1               5                  10                  15      
Met Pro Leu Gln Leu Leu Leu Leu Leu Ile Leu Leu Gly Pro Gly Asn
            20                  25                  30          
Ser Leu Gln Leu Trp Asp Thr Trp Ala Asp Glu Ala Glu Lys Ala Leu
        35                  40                  45              
Gly Pro Leu Leu Ala Arg Asp Arg Arg Gln Ala Thr Glu Tyr Glu Tyr
    50                  55                  60                  
Leu Asp Tyr Asp Phe Leu Pro Glu Thr Glu Pro Pro Glu Met Leu Arg
65                  70                  75                  80  
Asn Ser Thr Asp Thr Thr Pro Leu Thr Gly Pro Gly Thr Pro Glu Ser
                85                  90                  95      
Thr Thr Val Glu Pro Ala Ala Arg Arg Ser Thr Gly Leu Asp Ala Gly
            100                 105                 110         
Gly Ala Val Thr Glu Leu Thr Thr Glu Leu Ala Asn Met Gly Asn Leu
        115                 120                 125             
Ser Thr Asp Ser Ala Ala Met Glu Ile Gln Thr Thr Gln Pro Ala Ala
    130                 135                 140                 
Thr Glu Ala Gln Thr Thr Gln Pro Val Pro Thr Glu Ala Gln Thr Thr
145                 150                 155                 160 
Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Arg Leu Thr Ala Thr Glu
                165                 170                 175     
Ala Gln Thr Thr Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Pro Pro
            180                 185                 190         
Ala Ala Thr Glu Ala Gln Thr Thr Gln Pro Thr Gly Leu Glu Ala Gln
        195                 200                 205             
Thr Thr Ala Pro Ala Ala Met Glu Ala Gln Thr Thr Ala Pro Ala Ala
    210                 215                 220                 
Met Glu Ala Gln Thr Thr Pro Pro Ala Ala Met Glu Ala Gln Thr Thr
225                 230                 235                 240 
Gln Thr Thr Ala Met Glu Ala Gln Thr Thr Ala Pro Glu Ala Thr Glu
                245                 250                 255     
Ala Gln Thr Thr Gln Pro Thr Ala Thr Glu Ala Gln Thr Thr Pro Leu
            260                 265                 270         
Ala Ala Met Glu Ala Leu Ser Thr Glu Pro Ser Ala Thr Glu Ala Leu
        275                 280                 285             
Ser Met Glu Pro Thr Thr Lys Arg Gly Leu Phe Ile Pro Phe Ser Val
    290                 295                 300                 
Ser Ser Val Thr His Lys Gly Ile Pro Met Ala Ala Ser Asn Leu Ser
305                 310                 315                 320 
Val Asn Tyr Pro Val Gly Ala Pro Asp His Ile Ser Val Lys Gln Cys
                325                 330                 335     
Leu Leu Ala Ile Leu Ile Leu Ala Leu Val Ala Thr Ile Phe Phe Val
            340                 345                 350         
Cys Thr Val Val Leu Ala Val Arg Leu Ser Arg Lys Gly His Met Tyr
        355                 360                 365             
Pro Val Arg Asn Tyr Ser Pro Thr Glu Met Val Cys Ile Ser Ser Leu
    370                 375                 380                 
Leu Pro Asp Gly Gly Glu Gly Pro Ser Ala Thr Ala Asn Gly Gly Leu
385                 390                 395                 400 
Ser Lys Ala Lys Ser Pro Gly Leu Thr Pro Glu Pro Arg Glu Asp Arg
                405                 410                 415     
Glu Gly Asp Asp Leu Thr Leu His Ser Phe Leu Pro
            420                 425             


<210> 42
<211> 412
<212> PRT
<213> Homo sapiens

<220> 
<223> Exemplary amino acid sequence for human CLA precursor,
GenBank Accession No. NP_002997.2

<400> 42
Met Pro Leu Gln Leu Leu Leu Leu Leu Ile Leu Leu Gly Pro Gly Asn
 1               5                  10                  15      
Ser Leu Gln Leu Trp Asp Thr Trp Ala Asp Glu Ala Glu Lys Ala Leu
            20                  25                  30          
Gly Pro Leu Leu Ala Arg Asp Arg Arg Gln Ala Thr Glu Tyr Glu Tyr
        35                  40                  45              
Leu Asp Tyr Asp Phe Leu Pro Glu Thr Glu Pro Pro Glu Met Leu Arg
    50                  55                  60                  
Asn Ser Thr Asp Thr Thr Pro Leu Thr Gly Pro Gly Thr Pro Glu Ser
65                  70                  75                  80  
Thr Thr Val Glu Pro Ala Ala Arg Arg Ser Thr Gly Leu Asp Ala Gly
                85                  90                  95      
Gly Ala Val Thr Glu Leu Thr Thr Glu Leu Ala Asn Met Gly Asn Leu
            100                 105                 110         
Ser Thr Asp Ser Ala Ala Met Glu Ile Gln Thr Thr Gln Pro Ala Ala
        115                 120                 125             
Thr Glu Ala Gln Thr Thr Gln Pro Val Pro Thr Glu Ala Gln Thr Thr
    130                 135                 140                 
Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Arg Leu Thr Ala Thr Glu
145                 150                 155                 160 
Ala Gln Thr Thr Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Pro Pro
                165                 170                 175     
Ala Ala Thr Glu Ala Gln Thr Thr Gln Pro Thr Gly Leu Glu Ala Gln
            180                 185                 190         
Thr Thr Ala Pro Ala Ala Met Glu Ala Gln Thr Thr Ala Pro Ala Ala
        195                 200                 205             
Met Glu Ala Gln Thr Thr Pro Pro Ala Ala Met Glu Ala Gln Thr Thr
    210                 215                 220                 
Gln Thr Thr Ala Met Glu Ala Gln Thr Thr Ala Pro Glu Ala Thr Glu
225                 230                 235                 240 
Ala Gln Thr Thr Gln Pro Thr Ala Thr Glu Ala Gln Thr Thr Pro Leu
                245                 250                 255     
Ala Ala Met Glu Ala Leu Ser Thr Glu Pro Ser Ala Thr Glu Ala Leu
            260                 265                 270         
Ser Met Glu Pro Thr Thr Lys Arg Gly Leu Phe Ile Pro Phe Ser Val
        275                 280                 285             
Ser Ser Val Thr His Lys Gly Ile Pro Met Ala Ala Ser Asn Leu Ser
    290                 295                 300                 
Val Asn Tyr Pro Val Gly Ala Pro Asp His Ile Ser Val Lys Gln Cys
305                 310                 315                 320 
Leu Leu Ala Ile Leu Ile Leu Ala Leu Val Ala Thr Ile Phe Phe Val
                325                 330                 335     
Cys Thr Val Val Leu Ala Val Arg Leu Ser Arg Lys Gly His Met Tyr
            340                 345                 350         
Pro Val Arg Asn Tyr Ser Pro Thr Glu Met Val Cys Ile Ser Ser Leu
        355                 360                 365             
Leu Pro Asp Gly Gly Glu Gly Pro Ser Ala Thr Ala Asn Gly Gly Leu
    370                 375                 380                 
Ser Lys Ala Lys Ser Pro Gly Leu Thr Pro Glu Pro Arg Glu Asp Arg
385                 390                 395                 400 
Glu Gly Asp Asp Leu Thr Leu His Ser Phe Leu Pro
                405                 410         

