                               SEQUENCE LISTING

<110> UNIVERSITY OF IOWA RESEARCH FOUNDATION
 
<120> METHODS AND COMPOSITIONS FOR TREATING BRAIN DISEASES

<130> 17023.164WO1

<140> PCT/US2015/068034
<141> 2015-12-30

<150> 62/098,085
<151> 2014-12-30

<160> 4     

<170> PatentIn version 3.5

<210> 1
<211> 2092
<212> DNA
<213> Homo sapiens

<400> 1
ggcgtaatta aaaagcggcg gaagaaggtg ggagggtcat gacgcagcga gtttcagtcg       60

tgacttttct gggggcatcg cggcgtcccc tttttttgcc tttaaagtaa aacgtcgccc      120

cgacgcaccc cccgcgtatt tcggggggcg gaggcggcgg gccacggcgc gaagaggggc      180

ggtgctgacg ccggccggtc acgtgggcgt gttgtggggg ggaggggcgc cgccgcgcgg      240

tcggttccgg gcggttggga gcgcgcgagc tagcgagcga gaggcagccg cgcccgccgc      300

cgcccctgct ctgtatgccg ctctctcccg gcgcggccgc cgccgatcac agcagcagga      360

gccaccgccg ccgcggttga tgtggttggg ccggggctga ggaggccgcc aagatgccgc      420

agtccaagtc ccggaagatc gcgatcctgg gctaccggtc tgtggggaaa tcctcattga      480

cgattcaatt tgttgaaggc caatttgtgg actcctacga tccaaccata gaaaacactt      540

ttacaaagtt gatcacagta aatggacaag aatatcatct tcaacttgta gacacagccg      600

ggcaagatga atattctatc tttcctcaga catactccat agatattaat ggctatattc      660

ttgtgtattc tgttacatca atcaaaagtt ttgaagtgat taaagttatc catggcaaat      720

tgttggatat ggtggggaaa gtacaaatac ctattatgtt ggttgggaat aagaaagacc      780

tgcatatgga aagggtgatc agttatgaag aagggaaagc tttggcagaa tcttggaatg      840

cagctttttt ggaatcttct gctaaagaaa atcagactgc tgtggatgtt tttcgaagga      900

taattttgga ggcagaaaaa atggacgggg cagcttcaca aggcaagtct tcatgctcgg      960

tgatgtgatt ctgctgcaaa gcctgaggac actgggaata tattctacct gaagaagcaa     1020

actgcccgtt ctccttgaag ataaactatg cttctttttt cttctgttaa cctgaaagat     1080

atcatttggg tcagagctcc cctcccttca gattatgtta actctgagtc tgtccaaatg     1140

agttcacttc cattttcaaa ttttaagcaa tcatattttc aatttatata ttgtatttct     1200

taatattatg accaagaatt ttatcggcat taatttttca gtgtagtttg ttgtttaaaa     1260

taatgtaatc atcaaaatga tgcatattgt tacactacta ttaactaggc ttcagtatat     1320

cagtgtttat ttcattgtgt taaatgtata cttgtaaata aaatagctgc aaacctcagt     1380

cctttgtgct acttgatgtg gctttcaaag aagagaagcc ttgtcctgag tttctcactt     1440

ggcttcagga aggccccagg ttggattcca gaaaccagtg aagatgtggc cacaggagga     1500

ggtgtgctga ggtggctgct gaccgtggac tccctgcgca gtggcctgca gatgttgggg     1560

ctgggttaca gctgattgaa gctgagtggc cctggggggt ctgtgagggg agttcctccc     1620

cagtgatgaa attctctcct tccaccctca aatccctaga ccttgactga aatgctccgt     1680

ggtcgggagc ctggtcaagg aggaggagct gctgagaggc attgttcgcc cttgctcata     1740

gcttagctcg atgtccgtgt cagacaggag atgattgaga acagccttgc ctgtcactgt     1800

cctagaacac cctggagttt agtgttctgt gtcagagtct tgggagcctc cttcagaccc     1860

agatgacggg cctccctctg tccaaggagc agctgtaaag gagaagaggg atttcatttg     1920

tttggtggct gttaccttgt ctgtaagtca aacttggagt tgagcagtgc tttttaaacg     1980

attccctttt gcagctaaaa tttcacaggg ctatttctaa tacgtaagca aatgttacca     2040

ttgactttat taataaaata tagttttgct ttgcaaaaaa aaaaaaaaaa aa             2092


<210> 2
<211> 184
<212> PRT
<213> Homo sapiens

<400> 2
Met Pro Gln Ser Lys Ser Arg Lys Ile Ala Ile Leu Gly Tyr Arg Ser 
1               5                   10                  15      


Val Gly Lys Ser Ser Leu Thr Ile Gln Phe Val Glu Gly Gln Phe Val 
            20                  25                  30          


Asp Ser Tyr Asp Pro Thr Ile Glu Asn Thr Phe Thr Lys Leu Ile Thr 
        35                  40                  45              


Val Asn Gly Gln Glu Tyr His Leu Gln Leu Val Asp Thr Ala Gly Gln 
    50                  55                  60                  


Asp Glu Tyr Ser Ile Phe Pro Gln Thr Tyr Ser Ile Asp Ile Asn Gly 
65                  70                  75                  80  


Tyr Ile Leu Val Tyr Ser Val Thr Ser Ile Lys Ser Phe Glu Val Ile 
                85                  90                  95      


Lys Val Ile His Gly Lys Leu Leu Asp Met Val Gly Lys Val Gln Ile 
            100                 105                 110         


Pro Ile Met Leu Val Gly Asn Lys Lys Asp Leu His Met Glu Arg Val 
        115                 120                 125             


Ile Ser Tyr Glu Glu Gly Lys Ala Leu Ala Glu Ser Trp Asn Ala Ala 
    130                 135                 140                 


Phe Leu Glu Ser Ser Ala Lys Glu Asn Gln Thr Ala Val Asp Val Phe 
145                 150                 155                 160 


Arg Arg Ile Ile Leu Glu Ala Glu Lys Met Asp Gly Ala Ala Ser Gln 
                165                 170                 175     


Gly Lys Ser Ser Cys Ser Val Met 
            180                 


<210> 3
<211> 3047
<212> DNA
<213> Homo sapiens

<400> 3
cccttgcgcc tccttgcccg gccgcgccca gcccggcgtc ccgagcagcg caggggagga       60

tccccgcgca gtgacccggg agccaccaca gactctggga ggctcggcgg ctggagcagc      120

aggcagctcc ccgcagctcc cggcgcttcc aggcagctct ctgagccgtg ccagaggccc      180

ggcccgccat tcccagcccc gagccatgat gaagactttg tccagcggga actgcacgct      240

cagtgtgccc gccaaaaact cataccgcat ggtggtgctg ggtgcctctc gggtgggcaa      300

gagctccatc gtgtctcgct tcctcaatgg ccgctttgag gaccagtaca cacccaccat      360

cgaggacttc caccgtaagg tatacaacat ccgcggcgac atgtaccagc tcgacatcct      420

ggatacctct ggcaaccacc ccttccccgc catgcgcagg ctgtccatcc tcacagggga      480

tgtcttcatc ctggtgttca gcctggataa ccgggagtcc ttcgatgagg tcaagcgcct      540

tcagaagcag atcctggagg tcaagtcctg cctgaagaac aagaccaagg aggcggcgga      600

gctgcccatg gtcatctgtg gcaacaagaa cgaccacggc gagctgtgcc gccaggtgcc      660

caccaccgag gccgagctgc tggtgtcggg cgacgagaac tgcgcctact tcgaggtgtc      720

ggccaagaag aacaccaacg tggacgagat gttctacgtg ctcttcagca tggccaagct      780

gccacacgag atgagccccg ccctgcatcg caagatctcc gtgcagtacg gtgacgcctt      840

ccaccccagg cccttctgca tgcgccgcgt caaggagatg gacgcctatg gcatggtctc      900

gcccttcgcc cgccgcccca gcgtcaacag tgacctcaag tacatcaagg ccaaggtcct      960

tcgggaaggc caggcccgtg agagggacaa gtgcaccatc cagtgagcga gggatgctgg     1020

ggcggggctt ggccagtgcc ttcagggagg tggccccaga tgcccactgt gcgcatctcc     1080

ccaccgaggc cccggcagca gtcttgttca cagaccttag gcaccagact ggaggccccc     1140

gggcgctggc ctccgcacat tcgtctgcct tctcacagct ttcctgagtc cgcttgtcca     1200

cagctccttg gtggtttcat ctcctctgtg ggaggacaca tctctgcagc ctcaagagtt     1260

aggcagagac tcaagttaca ccttcctctc ctggggttgg aagaaatgtt gatgccagag     1320

gggtgaggat tgctgcgtca tatggagcct cctgggacaa gcctcaggat gaaaaggaca     1380

cagaaggcca gatgagaaag gtctcctctc tcctggcata acacccagct tggtttgggt     1440

ggcagctggg agaacttctc tcccagccct gcaactctta cgctctggtt cagctgcctc     1500

tgcaccccct cccaccccca gcacacacac aagttggccc ccagctgcgc ctgacattga     1560

gccagtggac tctgtgtctg aagggggcgt ggccacacct cctagaccac gcccaccact     1620

tagaccacgc ccacctcctg accgcgttcc tcagcctcct ctcctaggtc cctccgcccg     1680

acagttgtgc tttgttgtgg ttgcagctgt tttcgtgtca tgtatagtag tagaaatgga     1740

aatcattgta ctgtaaaagc ctagtgactc cctccttggc caggccctca cccagttcag     1800

atccacggcc tccacccggg acgccttcct cctctgctcc caaacagggt ttccgtggcc     1860

tgtttgcagc tagacattga cctccgccat tgagctccac ggtttacaga caattgcaca     1920

agcgtggggt gggcaggcca ggactgcttt tttttaatgc tcccatttca cagaggatac     1980

caccgagact cggaggggac acgatgagca ccaggcccca cctttgtccc ctagcaaatt     2040

cagggtacag ctccacctag aaccaggctg ccctctactg tgctcgttcc tcaagcattt     2100

attaagcacc tactgggtgc tgggttcact gtgtcctagg aaaccaagag ggtccccagt     2160

cctggcctct gcccgcccct gctgccccac caccttctgc acacacagcg gtggggaggc     2220

ggggaggagc agctgggacc cagaactgag cctgggaggg atccgacaga aaagctcagg     2280

gcgggtcttc tccttgtgcc cgggattggg ctatgctggg taccaccatg tactcaggca     2340

tggtgggttt tgaacccata aaccaaaggc ccttgtcatc agctcttaac aagtatattt     2400

tgtattttaa tctctctaaa catattgaag ttttagggcc ctaaggaacc ttagtgatct     2460

tctattgggt ctttctgagg ttcagagagg gtaagtaact tcctccaggt cacacagcaa     2520

gtctgtgggt ggcagaagca agctagcgct gggcattcag tacataccac gatgtgctcc     2580

ctctcttgat gcttggcccc tggggccttc agggctttgg gacatcttgt cctcaaccct     2640

ctccctagat cagtctgtga gggtccctgt agatattgtg tacaccatgc ccatgtatat     2700

acaagtacac acagatgtac acacagatgt acacatgctc cagccccagc tctgcatacc     2760

tgcacctgca ccccagcctt ggcccctgcc tgcgtctgtg ctcaaagcag cagctccaac     2820

cctgcctctg tccccttccc cacccactgc ctgagccttc tgagcagacc aggtaccttg     2880

gctgcaccgg tgtgtggccc gctctcaccc aggcacagcc ccgccaccat ggatctccgt     2940

gtacactatc aataaaagtg ggtttgttac aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3000

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                   3047


<210> 4
<211> 266
<212> PRT
<213> Homo sapiens

<400> 4
Met Met Lys Thr Leu Ser Ser Gly Asn Cys Thr Leu Ser Val Pro Ala 
1               5                   10                  15      


Lys Asn Ser Tyr Arg Met Val Val Leu Gly Ala Ser Arg Val Gly Lys 
            20                  25                  30          


Ser Ser Ile Val Ser Arg Phe Leu Asn Gly Arg Phe Glu Asp Gln Tyr 
        35                  40                  45              


Thr Pro Thr Ile Glu Asp Phe His Arg Lys Val Tyr Asn Ile Arg Gly 
    50                  55                  60                  


Asp Met Tyr Gln Leu Asp Ile Leu Asp Thr Ser Gly Asn His Pro Phe 
65                  70                  75                  80  


Pro Ala Met Arg Arg Leu Ser Ile Leu Thr Gly Asp Val Phe Ile Leu 
                85                  90                  95      


Val Phe Ser Leu Asp Asn Arg Glu Ser Phe Asp Glu Val Lys Arg Leu 
            100                 105                 110         


Gln Lys Gln Ile Leu Glu Val Lys Ser Cys Leu Lys Asn Lys Thr Lys 
        115                 120                 125             


Glu Ala Ala Glu Leu Pro Met Val Ile Cys Gly Asn Lys Asn Asp His 
    130                 135                 140                 


Gly Glu Leu Cys Arg Gln Val Pro Thr Thr Glu Ala Glu Leu Leu Val 
145                 150                 155                 160 


Ser Gly Asp Glu Asn Cys Ala Tyr Phe Glu Val Ser Ala Lys Lys Asn 
                165                 170                 175     


Thr Asn Val Asp Glu Met Phe Tyr Val Leu Phe Ser Met Ala Lys Leu 
            180                 185                 190         


Pro His Glu Met Ser Pro Ala Leu His Arg Lys Ile Ser Val Gln Tyr 
        195                 200                 205             


Gly Asp Ala Phe His Pro Arg Pro Phe Cys Met Arg Arg Val Lys Glu 
    210                 215                 220                 


Met Asp Ala Tyr Gly Met Val Ser Pro Phe Ala Arg Arg Pro Ser Val 
225                 230                 235                 240 


Asn Ser Asp Leu Lys Tyr Ile Lys Ala Lys Val Leu Arg Glu Gly Gln 
                245                 250                 255     


Ala Arg Glu Arg Asp Lys Cys Thr Ile Gln 
            260                 265     


