                         SEQUENCE LISTING

<110>  Centro Cardiologico Monzino S.p.A. - IRCCS
 
<120>  Prenylcysteine oxidase 1 inhibitors for the prevention and/or 
       treatment of oxidative stress-related degenerative diseases and 
       prenylcysteine oxidase 1 as diagnostic marker

<130>  128554 PCT

<150>  EP14200476.1
<151>  2014-12-29

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  23087
<212>  DNA
<213>  Homo sapiens

<400>  1
gcgcagccgc gcagcggtgg gaggactgcg gggctcttga ggccagctgc agagcttgtg       60

gaggccatgg ggcgcgtcgt cgcggagctc gtctcctcgc tgctggggtt gtggctgttg      120

ctgtgcagct gcggatgccc cgagggcgcc gagctgcgtg ctccgccaga taaaatcggt      180

aggcgagaag ggggcggcgc gggaaggtgc tggagcgcgc cccgcgccgg gcggccgctg      240

cgcagtgcgc ccagatccca cagccgcgac gcagtccagc ggtgcaggcc gagccagctg      300

cgcaggtcgc gctttccccc attcacactt cagggcggct ttcagctctg gtcggaatag      360

gactgtgcat tcccaggcgt ggagaggtgc ccacttgagg aatgggcgtg gacggggaca      420

ggggcgggcg ggcaggcagg cgcctagcgt acctgtagcc cctgtctctt aggtgtgggg      480

ctccggggag gcctaggttt ctctatcttc ccgttgaaca ctgaccgtga agactccagt      540

gttctggctt gacctggggc gcccggccag attaacaggc tcacgcaggc acagcacagg      600

gaggagtgca aacaagttga ccctgcctgc ttcccttggg aggctgaacc gccttccccc      660

agctccgctt tgctgaggtc ggcctgctct cagaggccct tggcttgcac agtttctccg      720

cctaggacta acacagctgc agaaagaatc tgttctcttt ccactgtcaa gagctccagt      780

gtcaggagcc ttggctcttt gcttcctgtc tccctcccgc ccccctttaa agttgtgttc      840

ttcggtatca ttaacctatc tacattgaat ctagacacaa caaagctagg cataaatggc      900

cgtcacttta ttaaaaatgc gtgctggaaa ggtccacctc taatgtgccc gtgagttggg      960

catctggaag ggtgtgcagg ccccttggtt cctccataaa gacctgtgag aatctttggg     1020

catctggaaa aaaaatcgag ttaatgtcaa tatgttaatt aatctactgc ttttgtctgg     1080

gaacagtgtc tgtccagatt cagggagtta gaccttcgct gcaggtgtca ctcttccccc     1140

accaaattgt tggtaatagc tttgagtaac aacctctgct attgatggtc tttcaaaaac     1200

aaaacaactc acagagctgg taaaagggga aaatataatc ttctgttttt ttccctcata     1260

gcgattattg gagccggaat tggtggcact tcagcagcct attacctgcg gcagaaattt     1320

gggaaagatg tgaagataga cctgtttgaa agagaagagg tcgggggccg cctggctacc     1380

atgatggtgc aggggcaaga atacgaggca ggaggttctg tcatccatcc tttaaatctg     1440

cacatgaaac gttttgtcaa agacctgggt atgtaatttt ggtcttggag ctcaccagat     1500

tactgtgtga catccccgga tatttttatc agatggagaa ctgaaatttc tgccttgtta     1560

attgccttac agagacgttg gtaaaactgt tttcctcact ttcttgttag ttggtactgc     1620

ctgagttagg agcagttctg ctgtaatggg acactagttg tctgtatctt cagttatctg     1680

gaattacagc catggggtgg gggtgggaat ggctgccatt gtcttttttt ttcttttgag     1740

gagtttcgct cttgtcgctc aggctggagt gcaatggtgc gatcttggct cactgcaacc     1800

tctgcctccc gggttcaagc gattctcctg ccttagcctc ctgagtagct gggattacag     1860

gtgcctgcca ccacgcccag ctaatttttg tattttcagt agtgacgggg tttcaccatg     1920

ttggccagct ggtcttgaac tcctgacctc aggtgatccg cctgccttgg ccttccaaag     1980

tgctgggatt acaggggtga gccaccgtgc ccggcctctg ttgtctgttc ttaaaattct     2040

gggtttgtgt taaagaatca gagaaggttt ggagatagtc atctcattgt gatcattttg     2100

cagctgagta aatgagaccc agagacttga attgtctggc tcaaagtcac tcacatatgg     2160

ccatggccag ggtcagtggc tcatgcctgt aatcccagca ctttgggagg ccgaggcaga     2220

ggatcacttg agcccaggag ttagaaacca gtctgggcaa catagtgaga tcctgtcttt     2280

actaaaaata aaaaagttag cctggtgtga tggcacaaac ctgtagtccc agcttcttgg     2340

gaggcagagg caggaggatc ccttgagcct gggagataga agctgcagtg agccttgcat     2400

gccactgcac tccagcctgg gcaacaaagt gagaccctat caaaacaaac caccaccaac     2460

aaaacaaact ccgtcacaca gctgtggatg cagacacgtg cctagaactt gggatgtgca     2520

actgctgccc tgacagcaga ggagctggat aggtcatggg gaaagtctga caggcctctg     2580

gaggcccttt cggcagggag tattttgtaa ctttggcctc cttccagtta tctgaaatat     2640

ccagttttgc aaaataggat tctcacagga atggaagtgc ctcagctgcc ttccacatcc     2700

tctgtagatg ctgcctctgc ttccgtttcc tccacgaggg cgaaggtata cccagaacaa     2760

attatgccac gaagatgcat gtctgacatc tttgttttta aattgaattc agttggtact     2820

ctggcttttt tcctttgact atccagtttt tttagacttt tagtctaaaa atagccaggt     2880

aaaaatatat ctacttttga tatattaata tttacatgat catctgaccc atcgcctagc     2940

aaatctgctt ttggacagtg tagtgaaagt atagtgtttc acactgttcc aaagatagag     3000

ctcctttatg tgtctcctga gaactgaggg aagccccaaa ttcactcaga ttacgttctt     3060

tcatttgatc agcatagaca ccactgactt agctgtgctt tatgtttttg caggtctctc     3120

tgctgttcag gcctctggtg gcctactggg gatatataat ggagagactc tggtatttga     3180

ggagagcaac tggttcataa ttaacgtgat taaattagtt tggcgctatg gatttcaatc     3240

cctccgtatg cacatgtggg tagaggacgt gttagacaag ttcatgaggt aatttttttt     3300

ccttccattt aacctaagat cttttaattt aggttaaatt aaacttgatg aactttagga     3360

attatgattt cttgtaagca ttttctacct cacagcaagg cctgtttata acattgttag     3420

gcaaaatgtt ttgtagaaac tatgcagact atttgcttgg atattgaaag gttggtttat     3480

ttttgcttct gaagtgtatt ttgcaaatgc ttctttagtg ttgccagata ctgttagatg     3540

ccttgaattc ttatgacaac ttactctggt aggtactgtt tttagcttct ttaaacagat     3600

gcagaaggtg gcggtgtaga gaggttttaa aaggcaagtt cacccacata gtaagtggta     3660

tagctggagt tgccacccag gcagtctggc ctttgagtct tcactcttaa tctctatgct     3720

gtgctggtgt tgtgtatatg aattgagata atgtgtacaa gagcttgtag aaaggatcag     3780

aaaacttaaa tggcctttaa tagtgacatg ttttcagtga accagcagcc tgaagtagag     3840

taaaagttcc atattccaag aatttacatt ctagcactgt tttgggtagt gagaattcag     3900

gtgcctcttt ttcgtcctta tgcttttcta tatttaaaca gtttttttaa tgcgtgtgaa     3960

tatgtatcac tttggtaatc aggaagacta acataaaata gccagtctaa ttttgaaagg     4020

tacaatctgt atttttaaag ctgttggcat gttctagttt tttagttttt ttgttttttt     4080

gtttttgaga tggagtttcg cttgttgcct aggctggagt gcaatggttc gatattggct     4140

cactgcaacc tctgcctctt gggttcaagc gatactcctg cctcaggctc ccgagtagct     4200

gggattacag atgcctgcca ccacgcccag ctaatttttg tatttttagt agagatgggg     4260

tttcaccctc ttggccaggc tggtctcgaa ctcctgacct caggtgatcc acctgcctcg     4320

gcctcccaaa gtgctgggat tacaggtgtg agctaccgag cttggccggc atgtgctaat     4380

tttttttttt tttttttttg agatggagtt ttgctctgtc gcccgggctg gagtgcagtg     4440

gcaccatctc ggctcactgc aacctctgcc tccctggttc aagcgattct cctgcctcag     4500

actcccgaat agctgggatt acaggtgcct gccactgtgc ctggctaatt ttttgtattt     4560

ttagtagaga cggggtttca ctgtgttagc caggatggtc ttgatctcct gacctcgtga     4620

tccgcctgcc tcagcctccc aaagtgttgg gattgcaggc atgagccact gtgcccggct     4680

agcacatgct aatttttatg ctgctttaca gttttaggta ctggaggcca ggatcgcatc     4740

attacactcc agcctgggtg acagaacaag attccatctt gaggggaaaa acaaaacaaa     4800

acaaaacatg tcatatgacc aggtattgaa caggacaaat atgagttaag cagggctggg     4860

cacagtggct tatgcctcta atcccagaat tttgggaggc tgaggctggt ggatcacctg     4920

aggtcaggag tttgagacca gcctgaccaa catggtaaaa ccctgtctct acaaaaaata     4980

taaaaattta gccggcgtgg tggtgcatgc ctgtaatccc agctacttgt gagcctgagg     5040

caggagaatc acttgaacct gggaggcaga ggttgcagtg agccacgatc gtgccattac     5100

actctagcct gggggacaga gccagactgt ctaaaaaaaa aaaaaagaaa gctaagcagg     5160

atatgctctg gtttctataa ctcatggtag tttggggttt ctttctttct caacatcatt     5220

cttaggtcag ttccttaaat gcctttcccg tgggtacctt aagtccatct acagtgcata     5280

atgtttttaa gtagccattc attcattcac ccaatattga atacctgtta ggtgctaggc     5340

attgttctat gttgagagta taggacctac aacatgtcct tgtcctcaaa gaatatatat     5400

tctagtggag agacaggcaa tacacaacca aggaaatata tagaatttgc gtagagacgg     5460

ccagtcactt tatagaaggt gggtggcatg gtgctgcata ctcagcaggc agatcaagtt     5520

ctgatggcat cagccctgct tgtgtgtatt gtttttcttt tcttttcttt tttttttttg     5580

agatagagtc tcgttttgtc gcccaggctg gagtgcagtg gcgggatctc ggcttactgc     5640

aacatctgcc tcccaggttc aagtgattct cctgcctcag cctcctgagt agctgggact     5700

acaggcacat gccaccatgc ctggttaatt ttttgtattt ttagtagaga tgtggtttca     5760

ccgtgttagc caggctggtc tcaaactcct gaccttgtga tctgcctgtc tcggcttccc     5820

aaagtgttgg gattataggc gtgagccact gtgcccggcc ctcttttttt tttttttttt     5880

tttgatacag gtctcactct gtcacccagg ctggagtgca gtggtgtgat catggctcac     5940

tgcagcctgg acctcctggg ctcaggggat ctgcctacct tagcctctgt gtagctggga     6000

ctacaggcac gtgccatcag atctggctaa ttttttgtat tttttttgta gagatgaggt     6060

ttggccatgt tgcccaggct ggtcttgaat tcctgggctc gagtgttcca ctcacctggg     6120

cctcccaaag tgttgggatt acggttgtga gctcctgttc ccagccttgt tttttttttt     6180

atctgtggct tgcttgagat gtagagaatt gccctttgag aaattaagaa attacttttt     6240

tttttttgag atgagtttca ctctgtcacc caggctggag tgcagtggtg caatctcggc     6300

tcactgcaac ctctgcctcc tgagtccaag cgattctcct gcctcagcct cctgagtagc     6360

tgggattaca ggcatgtgcc accataccca gataattttt ttatttttag tagagatggg     6420

gttttaccat gttggctagg ctggtctcaa actcctggcc ttaattgatc tgcccgcctt     6480

ggcctcctaa agtgctgcga ttacaggcat gagccaccgc acctggccta agaaatcact     6540

tttgaagtga attcaaggta ttacagaact gggaaaaaga accagtgagg ggatacatag     6600

gttatactgt ttttgacttt aaaaaataat ttacgggccg ggcgcggtgg cacacgcctg     6660

taatcccagc actttgggag gccaaggcag atagatcttg aggtcaggag ttcgagacca     6720

gcctggccaa catggtgaaa ctccgccttg ctaaaaatac aaaaattagc tgggtgtgga     6780

ggcgcagcta atgccagcta cttgggaggc tgaggcagta gaatcgcttg aacccaggaa     6840

gcggaggttg tggtgagcca agatcaaagt atacacaagg tggagaaaga cctatgtaac     6900

agtagtaaac catgacactc gaaagagggc tcaagcttgt ggtaggcaat actcgaaaac     6960

agtgcattca ttcattctct gctgttggag gtacttgagt ggaaatcctg cagcccctga     7020

catcagcact agctagctta atttccactt ctgcacatac atttatgtag ttgttctggt     7080

tggatgccat tcttaactaa tttttttttt tttttttttt ttgagaccaa gtcttgctcc     7140

gtcacccagg ctggagtacg gtggtgcaat cacagctcac tgcagctttg acctcctggt     7200

ctcaagtcat cttccagcct cagctgggac tataggcatg tgccatcatg cttggctaat     7260

tttttaaatt tttgtagaga cagggtgttg ccatgttgcc caagctgatc ttgaactcct     7320

gggctcaagt gatcctccca ccttggcctc ccaaagtgtt gggattacag gcgtgagcca     7380

ccgcgctcag ccggatgcca ttctttactc ccaagtccaa cctcttatct cactttttca     7440

gcaaagcatt tccttaatgc ttcaatcaac attcatcttt cttttcaaac atcccttatt     7500

atacggtgca cactgtgtgc ttgtgttcta tgctacgcac agtaactaga atgtagtaga     7560

tgtttactca gatgtttgtg gaatttaaat ctctggtctg ctgatggctt cctgttgaga     7620

tatcttggct tgtagactag gttaaagctt attcttctct ctcaagttag tgcatttctg     7680

gggacttgta agatccttaa cacttcttga tctgagactg atagactcac agggaaaggc     7740

tttataaaca ccctttcttc cttccagtta ctcctaccaa atattttgag tcaatttttg     7800

ttctttcatt tcccaaaccc actctatctt gaatcccatc agcctttaaa atacatccag     7860

tattccacta cttctctcca ggattactgc taccactttg ttccaagtca ccaccactgt     7920

ctcttgtctg gattgctaga gtagcctcct attataggct gaataatcct ctcccctgct     7980

gtctgccaca agatgtccat gtcttaattc ctggaacctg tgaatgtgtt accttttgag     8040

gtaaaagaga cgttgcagat atggttaagg atgggtagat tattctggat tatctaggtg     8100

ggcccaatat aatcacaagg gtccttagag aggcaggagg atcagggtag gtagtaggag     8160

atgtgatgat ggaaggaaga gattggagtg atgctaggaa ggggtgtgcg tccacgagcc     8220

aaggaatgca ggtggcctgt agaggctgga aaagacagtc ttccctcaga gcttctagaa     8280

ggaaccagcc ttgtgcacac cttgatttta gcccggagag actgactttg gtcttctaat     8340

ttacagaacc gtaagattat aacttttttt ttttttgtta gtatttatta atcattcttg     8400

ggtgttcttc ggagaggggg atttggcagg gtcataggac aatagtggag ggaaggtcag     8460

cggataaaca tgtgaacaaa ggtctctggt tttcctaggc agagggccct gccgccttcc     8520

gcagtgtttg tgtccctggg tacttgagat tagggagtgg tgatgactct taacgagtat     8580

gctgccttca agcatctgtt taacaaagca catcttgcac cgcccttaat ccatttaacc     8640

cttagtggac acagcacatg tttcagagag catggggttg ggggtaaggt catagataaa     8700

cagcattcca aggcagaaga atttctctta ctacagaaca aaatggagtc tcctatgtcc     8760

acctctttct acacagacac agtaacaatc cgatctctcc ttcctttccc cacatttccc     8820

ccacttctat tcgacaaaac tgccatcgtc atcatggccc gttctcaatg agctattggg     8880

tacacctccc agacggggtg gcggctgggc agaggggctc ctcacttccc agacagggcg     8940

gctgctgggc ggaggggctc ctcacttctc agagagggcg gctggtcaga gaggctcctc     9000

acctcccaga cgggatggcg gcggggcaga gacactcctc agttcccaga cggcgtcgcg     9060

gccgggcaga ggcgctcttc acatctcaga cggggcggcg gggcagaggc gctccccaca     9120

tcccagacga tgggcagccg ggcagagacg ctcctcactt cctagacggg atgacggccg     9180

ggaagaggcg ctcctcactt cccagactgg gcggccgggc agaggagttc ctcacatccc     9240

agacgatggg cggccaggca aagacactcc tcacttccta gacggggtgg cggctgggca     9300

gaggctgcaa tctcagcact tttgggaggt caaggcaggc ggctgggagg tggaggttgt     9360

agcgagccga gatcacgcca ctgcactcca gcctgggcaa cattgagcac tgagtgagcg     9420

acactccgtc tgcaatcctg gcacctcggg aggccgaggc tggcagatca ctcatggtca     9480

ggaactggag accagcccgg ccaacacggt gaaaccccgt ctccaccaaa aaatacgaaa     9540

accagtcagg cgtggcggcg cgcgcctgca atcccaggca cttggcaggc tgaagcagga     9600

gaatcaggca gggaggttgc agtgagtcga gatggcagca gtacagtcca gccttggctc     9660

ggcatcagag ggagaccgtg gagagggaga gggggagggg gagggggaga gggagagctg     9720

ttttttgttt tgagacagag tcttgctctg tcacccaggc tggagtgcag tggcacaatc     9780

ttggctcact gcagcctccg cctcctgggt tcaagcagtt ctctgcctca gcctcccgag     9840

tagttgggat cacaggcgcc caccaccatg cccggctaat ttttgtattt ttagtagaga     9900

tggggtttca ccatcttggc caggcaggtc ttgcactcct gacctcgtga tccacccgcc     9960

tcagcctccc aaagtgctgg gattacaggt gtgagccact gcacccggcc gtaaatttgt    10020

gttgttttaa gccactaagt ttgtggtaat ttgttatagc agcagtggaa aaccaagaca    10080

cctcctaaat catctgccat tactgttata ttgctaccat ttgttctcag gttagcagcc    10140

aaagtagttc tttaaaatct aaggctcatc acatcactcc actaactcag aaaccttcag    10200

tggctatttc attaatagag atttatagcc aaaatctgtt ttgtgactga gaagacatga    10260

caggattctg tgctctcatc ccttactttt aaatttgttt tccccaaaat tcataggttg    10320

aaacactagc cacccagtac tcagaatgtg actgcatatg tatgtagggc ctttaaatat    10380

gtgattaagt taaaatgagg tctttagcgt agaccctaaa acaatttgat gggtgtcctt    10440

aagattagga cacagaaagg aggccaaggc gggcagatca cctgaggttg ggagttcgag    10500

accagcctga ccaacatggt gaaacccctt ctctactaaa aatacaaaaa attagctggg    10560

cgtggtggtg catgcttgta atcccagcta ctcaggaagg ctgaggcaag agaatcactt    10620

gaacctgggc ggcagaggtt gcagtgagcc attgcactcc agcctgggca acaagcgtga    10680

aactctgtct cagaaaaaaa aaaaaaaaaa ttgggacaca gaagaaacac acaaagacca    10740

tgtgaggaca cagcaagaag gtggccatct gcaagccaag gaaataggcc tcagaagaaa    10800

ccgaatgcat ccacaccttg atcttggact tttggcctac agaactataa gaaataaaac    10860

tttttttgtt taagccatcc agtctttggt actgtgttat ggcagtcttg gtgaactaat    10920

acactgttgt cattttcagt aactgtccat tattgaaaat gggatattga agtctccatt    10980

attgttgaac tatgtatttc agttctgtca agatcatttg atcatattca tgaaggttta    11040

tttctgggtt ttcttatttg tttcaaggat ctgtgtgtct gttttttttt ttttttcaga    11100

tgatgtttta ctctgttgcc caggctagag tgtagtatgt tcacagcaac ctctgcctcc    11160

caggctcaag caattctcca acctcaggcc ccttgagtgg ctgggactac agatgtgcac    11220

taccatgccc agctaatttt tttttttttt tttttgagac agagtctcgc tctgttgccc    11280

aggctggagt tcagtggcgc tatctcggct cactgcaacc tctgcctccc gggttcaagc    11340

aattcttgtg cctcagcctc ctgagtaggt gggactacag gcatgcacca ccaaccctgg    11400

ctaatttttt gtgtttttag tagagatggg ttttcgccat gatggccagg ctggtctcga    11460

actcctaacc tcaagtgatc ctccagcctg tgcctcccaa tgtgctggga ttacaggcgt    11520

gagccactgc acccggcctt ttttaaaaag tttttttggt cagcctcttg tagtctctat    11580

tgatgtcata gcctccggca tctgtgatgt taaacaattg ccacagattt tttttttgac    11640

acgtggacac gtgccctcag gatggggctg ttgcatagag tgaactttga atcaggtcga    11700

ataaagacaa gccttcagga tagagctttt tcggagctgc cagataggtc aaatattgac    11760

agttctctga ggatagtgct ttttgggagc tacaaactcg ttgtgttctc tccagtggct    11820

tctagcttgc tagtttcaca ttgcagttgg aagggtgctg gttttatttt ttattttttt    11880

ttctctctct ctttttctct ttctttcttt ctttcgacgg agtctccctc ttgtcgccca    11940

ggctggagtg caatggtgcg atcttggctc actgcaacct ccatctcctg ggttcaagcg    12000

attctcctgc ctcagcctcc tgaatagctg ggattacagg cgtgtgccac cacacctggc    12060

taatttttta tatttttggt acagatggtg tttcaccatg ttgggcaggc tggtcttgaa    12120

ctcctgacct caagtgatcc gcctggctca gcttcccaga gtgctgggat tacaggtgtg    12180

agccaccatg cctgccagac atttttcttg aataaatact ccttggactt ggaaaggctt    12240

tggtttatct gcagagctct gaaagagtca atgttgatca tttttggcag tattctcata    12300

gcttttatgg aggagcagat ttccagaggt ccttcctctg ccattctgga agtttcctct    12360

ccccagtaac atttctggct gtaccactcc cggttctccc atatcactct gcttcagctg    12420

ctctggcttc attgtttctt gaatgtgcca ggcaagcttc tgtcatgtga cctttgcatt    12480

gcttttacct ctaccggaaa tattttcccc caggtgtttg cctggtttgc atcctcatct    12540

ccttcgggtc tttggtctat atcatcttct cagtgaggct tttcctgacc actcttgttt    12600

ttggacagtc ttatttagaa ttcaaccctc ctaaccccat gtatttctag tcttcttttc    12660

agaccatttt ctcctttttt ttttcttttg agatggagtc tgtctctgtt gcccaggctg    12720

gagtgcagtg gcacgatctt ggctctcctc ggctcacctt ggctcactgt gccactgcac    12780

cactacgccc ggctaatttt gtatttttag tagagacagg gtttctccat gttggtcagg    12840

ctggtctcga actcctgacc tcaggtgatc cacctgtctt ggcctcccaa agtgctggga    12900

ttacaggcgt gagccactgt gcctggcccc agttatattt ttttaaaaat tattattttt    12960

ttgtttttgt ttttgttttt tttaagacaa ggtctcactc tgttgcccaa gctggatgga    13020

gtgcagtggt gtgatcacag ctcactgcag cctcaaccag cggggctgaa gtgatcctca    13080

tgcctcagct tcctgaatag ctgggactac aggcatgcct caccatgcct ggctaatttt    13140

tttttttttt tttttctgta agtattttat ttatcactga agaaaaaaca cagcagcaag    13200

ttctgtgttg gcttcaatga gaccaaatag ttcatcttta acatagctac tgcgctccaa    13260

aattgaagtc aacacagtca ttactacaaa ttacttgttg aaagaatcta tcttcaaaag    13320

aaagaaaatt aggaaagaga atttaaacga ttcctccaaa ccatacattt ataaatattg    13380

tcatatttaa aatgcttgaa aggcgtgaat tctccattaa tggaaaagca gtttgctatt    13440

ggcaacagaa aaaaactcag cgataattta ccaaatgctt taaaatttaa aagctatact    13500

gtttggattc acacttgcgc agtaatcttg tcattacaac aactgcaaat tgctttgtac    13560

tcaccttctc tcaagtaaaa tctaaagaaa accccaccgt atccaatgtt tgtaatgttt    13620

acttcaagtg aatctaaaaa atttctaaat ttagtttatg gtaaatacct caaaatacct    13680

aaaaataggt acgtatcaac cacttaaggg tgtgaaaatt gtttcagatt cactgcttta    13740

aagggtcttc aaatatattt tctttaacag aaccttactt cattccaaat tattatcaga    13800

tatttcaaaa taaaaaaaaa gtatcagttc tataccaaga taaaggtgtt actcaatacc    13860

tgaaggttca cattttaaat ttatttttta gtttttcttt tttgtcaaca aatgattgat    13920

gaaataatgc aacaccctta aattccagaa aatggcatgg tttttccaac ctcctgtgga    13980

tatggtgcat gatcaatcta ttatatagga gcctggctaa tttttaattt tttttttttt    14040

ttttttgaga gggagtttca ctctgtcacc aaggctagag tgcagtggca cgatctcggc    14100

tcactgcaac ctctacctcc caggttcaag cgattctcct gcctccacct cccaagtagc    14160

tggtattaca ggcatgcgcc accatgccca gttaattttt gtatttttag tagaggtggg    14220

gtttcgctat gttggccagg ctggtctcaa actcctgacc tcaagcgatc tgcccgcctc    14280

agcctcccaa agtgctggga ttacaggcat gaaccactgc gcctggctaa tttttacatt    14340

ttgtgtacag acagagtctt gctatgttgc ccaggctagt cttgaactcc tggcctcaag    14400

gtatcctcct gtcttactct gtcacccagg ctggagtata ttggctggct gttcacaggt    14460

gcaaccataa tgtactacag ccttgtgccc ctgggcttaa gtgatcctcc cacctcagcc    14520

tcttgagtag ctgtgactac aggtgcatgc tgcctcacct gggtgctgtt ttttagtagt    14580

atttattctg ttttttcatt tattattatt atttttttga gatggagtct tgctctgtca    14640

tccagggtgt agtgcagtgg tgtgatcttg acttactgca acctctgtct cctgggtcaa    14700

gcaattctca tgcctcagcc acctgagtag ctgggattac aggcatgcac caccacacct    14760

ggataatttt tgtattttta gtagagatgg ggtttcacca tgttggccag gcggtctcaa    14820

actactgacc tcaagtgatg ctgccccact ttgcctccca aagtgctagg attacaggca    14880

tgagccacca tacccagcag tgtatttatt ctaatacgat tagttgtatc atgaaacaat    14940

tagagtgctc tctgtttata ttgtgtatat agtttcatct caccgctgcc accccgcccc    15000

ctcccaggga gacttgcttg agtgaggttg cagctctggc aggagcagtt ggggaatatg    15060

ttttttatag catcattagt agcttattta attgactgtt attttctcat gttgaccatt    15120

agccaaagat cactcttctt tggatatgag atatccaggc tattattttt ctgaagaatt    15180

cagtgtttcc atcctacttt ttccagtctc ctaaagactg ggacccaaat gctatggtta    15240

gaaggtattt agtttctcag ttttggcata gatatcgaat cagtttttcc aataaaaatg    15300

tgtttaacat tttgtacact tatactacta ctatgctttt agtaggtaat actgaaatgg    15360

ttataatact gtcccttgtt ctgtaaaaaa atatagtaca ttttgagaga aaaacttgat    15420

gtgaaagttt cccttccatg atcagtgata gggatctttc cttggctctt aatttcttat    15480

tttcatatac ttatctctgc atgtgcctta ttacttatcc ctaactataa gccccttaag    15540

ggaataagag ataaaccccg tattacttat cccaaactta agcctgtttt ccatctttgt    15600

actatttgca acatgaaaaa ttgtgtttga attactgaat gcactaattt atgtgaatgt    15660

tgttttaaat ccataaaatg cagagaagtg ttgggtgata tttttctttt tggtcaagtg    15720

atgttttcta aaaaataata gaaagcatct aattgttgaa tgagtggcat tggtgctaag    15780

ttttatgagg cttctggaga tgatataact gtggactggg aagttgagca agacttttca    15840

gagaaggtgg gattcaagtt ctgttaagga agaatagatg ttccatggtt aggaatggga    15900

agtgtattca ggttggaggg aagagcttgt gcactggtgg ggatacagca tgtagggcaa    15960

atttagagac cagtgaatgg gtcaggtgtg ctccagtgga gactgtgcat gtgtgggtga    16020

ttgacagcag agtgggcaag ttgtgattga gccttatact tgccatgtgg cctttagaca    16080

aagtatttta cttctacttt tttttttttt tttttttgag atggagtctc gctctgttgc    16140

ccaggctgga gtgcagcggt gtgatctcgg ctcactgcaa cctccgcttt ctgggttgaa    16200

gcgattctcc tgcctcagcc tcctgaatag ctgggattac aggcgtgcgc caccaggccc    16260

agctaatttt tgtattttta gtagagacgg ggtttcacca tgttggtcag gctggtctca    16320

aactcctgac ctagtgatct gcctgccttg gccttccaaa gagctaggat tacaggcatg    16380

aaaccaccgc gcctggcctt acttctactt tttatttttc ctttttcttc ttctttcttt    16440

cttccttagt ttcttttctt tttttttttc tttttttttt tttaagagac actgtcactg    16500

tctggcccag gctggagtgc agcggcatta tcacagttca ctgcggcctt gaattccggg    16560

gctcaagcag tcctcctgcc tcagcctccc aagtagctgg gaccacaggc atacaccact    16620

atgcctggtt aatttttgta tttttagtaa agctggggtt ttgccatgtt ggccaggctg    16680

gtcttgaact cctgacctca ggtgacctgc ccacctctgc ctcccaaagt gtggggatta    16740

taggcgtgag ccactgcacc tagatgtcag tttgattctt atgacgccac ttcccttctt    16800

tatacatccc cttccccaca tcttgtttgg tatttaatgg atttctcttc ttttccaaag    16860

gatctaccgc taccagtctc atgactatgc cttcagtagt gtcgaaaaat tacttcatgc    16920

tctaggagga gatgacttcc ttggaatgct taatcgaaca cttcttgaaa ccttgcaaaa    16980

ggccggcttt tctgagaagt tcctcaatga aatgattgct cctgttatga gggtcaatta    17040

tggccaaagc acggacatca atgcctttgt gggtaagcca gggcttgaaa cagtggtgga    17100

cattagttca cagaggggct tacctgatgc tatggtggtt cctgacttta ggctgtggat    17160

tggaggctac ttttctctgt gaacctcaga cattgttagc aaaattgtgc gtatgtagat    17220

gtgcattttt agggggagag ggtctttagc tttcattagt tcagtaattc ttaactgggg    17280

gagattttgc tcccaggggc catttagcaa tgtctagaga catttggagt agaacatgta    17340

attgggaagg gagagtgggt agagagcctc ttacaaaaag tcagaattaa aacacatttt    17400

tcctcctatt gacaggggcg gtgtcactgt cctgttctga ttctggcctt tgggcagtag    17460

aaggtggcaa taaacttgtt tgctcagggc ttctgcaggc atccaaaagc aatcttatat    17520

ctggctcagt aatgtacatc gaggagaaaa caaagaccaa gtacacaggt aagcttgaat    17580

ttcttattgt tcctgatatc ccctgcagaa aatgattgct cagggagaaa cacttctctt    17640

ctgtcatctc ttactcagtt ctaaaatgat gaaacttgaa attgtatata ttgtaccata    17700

tagaaatatt ccccaatggg ccaggcacgg tggctcatgc ctgtaatccc tgtactttgg    17760

gaggccaagg agggtggatc acctgaggtc aggagatcaa gactagcctg gccaacatag    17820

ttaaaccctg tctctactaa aaatacaaaa aattagccgg gcgtggtggc aggtgcctgt    17880

aatcccagct actcgggagg ctgaggcagg agaatcacat gaacccaggg ggcagaggtt    17940

gcagtgagcc aagatcacac cactgcactc tagcctgggt gacggagtga gactccatct    18000

aaaaaaaaaa aaaaaaaaaa aaaattcccc agtgtagtta agtgctgtgg catcactcct    18060

tggatttgaa aaataatctt tttttttttt gagatggagt ctcgctcttt tgcccaggcc    18120

ggactgtagt ggcctatctc ggctcactgc aagctccgcc tcccgggttc acgccattct    18180

cctgcctcag cgtcccgagt agctgggact ataggcgcct gcctcagcgt cccgagtagc    18240

tgggactata ggcgcctgcc accgcgctcg gctaattttt tgtattttta gtagagacgg    18300

ggtttcacca tgttagccag gatggtctcg atctcctgac ctcgtgatcc acccacctcg    18360

gcctcccaaa gtgctgagat tacaggtgtg agccaccatg cccggccgaa agataatctt    18420

accttcaaaa gtaaaaattc tgtattttgt acttactgac attctgaata agaaattggc    18480

ctcaatgtaa taaaaatgca agggacaact atcttaaggg atataacttc ttcaattctt    18540

tagaattata gagaaattat gaagaaggta tacaattatt tttagaaggt atgttagaaa    18600

cactaaacaa atatatgcct ccttatttcc tctaggaaat ccaacaaaga tgtatgaagt    18660

ggtctaccaa attggaactg agactcgttc agacttctat gacatcgtct tggtggccac    18720

tccgttgaat cgaaaaatgt cgaatattac ttttctcaac tttgatcctc caattgagga    18780

attccatcaa tattatcaac atatagtgac aactttagtt aagggggaat tgaatacatc    18840

tatctttagc tctagaccca tagataaatt tggccttaat acagttttaa ccactgataa    18900

ttcagatttg ttcattaaca gtattgggat tgtgccctct gtgagagaaa aggaagatcc    18960

tgagccatca acagatggaa catatgtttg gaagatcttt tcccaagaaa ctcttactaa    19020

agcacaaatt ttaaagctct ttctgtccta tgattatgct gtgaagaagc catggcttgc    19080

atatcctcac tataagcccc cggagaaatg cccctctatc attctccatg atcgacttta    19140

ttacctcaat ggcatagagt gtgcagcaag tgccatggag atgagtgcca ttgcagccca    19200

caacgctgca ctccttgcct atcaccgctg gaacgggcac acagacatga ttgatcagga    19260

tggcttatat gagaaactta aaactgaact atgaagtgac acactccttt ttcccctcct    19320

agttccaaat gactatcagt ggcaaaaaag aacaaaatct gagcagagat gattttgaac    19380

cagatatttt gccattatca ttgtttaata aaagtaatcc ctgctggtca taggaaaaca    19440

cacggttcta attaagtgtg aaggtatagc tattgcactt atgccatctc caaaatttct    19500

taagtattct ttcactatcc attaggagtt tttcttaaac ttgtctgata ataagaatca    19560

cctggagtta ggaggtggtg gttgcagtga gccaatctca ccattgcact tcagcctgag    19620

caacacgagc aaaactccgt ctcaaaagta aataaaaata atcacctgga gtttgttaaa    19680

ccatatggat tctcaagctc ctctcttgaa gattctgatt cagtaggtct gggagtggcg    19740

cgctggattt tgatcaaaat tgtagagcat tttaaggtga gtacctgagg gagaacttaa    19800

agacatctta gttggggagt agtccttttg aattttacag ctagatataa tcttcagtca    19860

gataaaattt atgggagctg gtgtcttatg cctgactctt agtaatttca taccggtttg    19920

aagtacgtgt gcccatgcct aaagccttga ctttcagaat gttgtctttt gattcttctg    19980

tcttgatttg attaggggtg aaatttagaa gtcttagtaa tgtaacttga agatgttaaa    20040

caaaaatctc aagtaaaatg aaaagcaaat atgggctact gaattaagaa actggcattc    20100

tagtattaaa tcctcacttc aggagctttt aaaaatactg agaccccccc ataaccagag    20160

attcagattc aaagactgag gataggacct tagcattgta gctatttaaa gtttctaatg    20220

tgcacccagg gttgggaatc accaatgtgg gtgtgaaaat gcctacaaag ggttttagtg    20280

ccttagaagt cctaagaagc ccaatctgta tcaaagcaga tccattttgc aaggatcttt    20340

cttttagaac tttctcagtt ctcttagtaa gaactttaga agtaatcttg ataataagca    20400

cagacagcct aacagcagag gcaacttaaa taactcctga gcagttggca ctagaacaga    20460

atacttggaa tgacaccaaa gttaaccaag tccagcatat gtccaaagag ttaagtgttt    20520

catttactgt agcattctgg gtgagaaatt ggttgctgaa atcttaagac agtggtctca    20580

accttggctg cacattggaa tcacctgtag ggttttaaag catccaaatg gtaattaaca    20640

ggcagcaaaa cttcagaact agttctgcat ctactgtgca aagatcatga ttaactgtca    20700

agacactggt agaacagaac aagcaaaaga ttaagagttc aaaagtaaat gcaaccaatt    20760

taacatgtag tgttattaaa aaattacaaa ggcctagacc agcctgggca acatggtgaa    20820

accccatctc tacaaaaaat ttttaaaaag ttggccaggc atggtaatgc gcgcctgtgg    20880

tcccagctgc tcgggaggct gaggtgggag gatcacttga gccttggagg tcaaggctgc    20940

agtgaatcat gatcatgcca ctgtactcca gcctgggcaa cagagaccat cttaaaaaaa    21000

aaaaatcctt ccattgaata gaaacttcaa agtccttcat cagatcatgg cattagctac    21060

tttagcaaaa tagtgtaaac tttggttctg agtaaaaatg acttcttccc taccacagtt    21120

gtgaatgtta atatgctgat aaaactgcca agatatattt gataggtagg ggattaaact    21180

catggtttgt caaaagagtg tttttttcta gttttattct taacagatat gttgaggtat    21240

tcatatttgt ttccttttgt ggttttaatg aagacaattt gtaaagtaat actgttatgt    21300

atatgctaaa tgttggtaaa tactaattaa tttccatcat ttgtagactt gttttgcaat    21360

gggatatatt tttacttata ataccaattt aggctgggcg cagtggctca cgcctgtaat    21420

cccagcactt tgggaggcca aggcaaacgg atcacgaggt caggagatca agaccatcct    21480

ggccaacatg gtgaaacccc atctctactg aatacacaaa aattggctgg acatggtggc    21540

gcatgtctgt aatcccagct actgtaatct cagctacttg ggaggctgag gcaggagaat    21600

tgcctcaacc gggaggcgga ggttgcagtg agccaagatc gcaccactgc actccagcct    21660

ggcaacagag cgagactctg tctcagaaaa aaaaaacaaa aaccagttta ggctgggtat    21720

ggtggctcac cagcactttg ggaggctgag gcaggtggat ctcttgaggt cgggagtttg    21780

agaccagcct ggccaacatg gtgaaaccct gtctttacta aaaatacaaa aattagccag    21840

gcatggtggc gtgtgccagt aatcccagct acttgggagg ctgaggcgcg agaatcgctt    21900

gaaccctgga gatggaggtt gcagtgagca gagatcgcac cactgcactc cagcctgggc    21960

aagagtgaga ctgtgtctca aaaggaaaaa aaaaaaatta aaaatgttgc tggtattaca    22020

tcaaacctac tctggataaa ttttccagta gggcatctga aattgctttg gcaaaagcaa    22080

aacaggttat caatacacca aggacatcaa gtagttttaa tgcaactaca gtgttgagtg    22140

cttttttact gggagaaaaa tcctagcaga acctgctact ctgggcgcat taggtagttt    22200

tatgcaacta tagtattaag agttttattg gaagaaaaaa cactgtcaga gcttactgct    22260

ccagaccttt ttttttaata gaagagactg gtaaaaatga tgcaggggct gaatgaaagc    22320

cagctctgct ccagtggctc tctgagttga gcatgcatca gttaccttaa gggcttgtta    22380

aaacatcgct aggctccacc ctgtttattc aataagtttg ttatgggata taagaagatg    22440

cattttatta agttccccag tgatgctgct gttctactat aggaaccaca cttgaagaac    22500

tagttctaca attcagctgt atgttgtaaa ggagtcaagt caatgaagga gttataaaga    22560

gttgctgaaa aatggagtaa cagtgtatgg gacttcacat cagttctcct tattgattgt    22620

tagtttgatc cctcttgttc ttttgttgta aacattttct ataattagga aatgccattt    22680

aagagtgaga gaggtatata tctatgagcc attgtgtttg gtgttttaca agaactttac    22740

catactggtg tgtagtccat tctgtacagt ttaaaagtga ttcacgattt gcaggctttt    22800

tatcagatca caaaaaaatc agtctttaag catttgcttg gtaaggtttc ttaagattag    22860

gtttataata caaccatctg taatgtatct ctcgtttgag cttgtgggcc atacaattca    22920

ttaactagat gaatacattg tggacagcat cctcactacc cctctctact cactcacaaa    22980

gaaccatgat acactggaat gtttttctct ggaatcctct ttctactctt gtattaaaat    23040

ttttccccac ttcatgatta tattcaaaat aaacaactac atcatta                  23087


<210>  2
<211>  5377
<212>  DNA
<213>  Homo sapiens

<400>  2
gcgcagccgc gcagcggtgg gaggactgcg gggctcttga ggccagctgc agagcttgtg       60

gaggccatgg ggcgcgtcgt cgcggagctc gtctcctcgc tgctggggtt gtggctgttg      120

ctgtgcagct gcggatgccc cgagggcgcc gagctgcgtg ctccgccaga taaaatcgcg      180

attattggag ccggaattgg tggcacttca gcagcctatt acctgcggca gaaatttggg      240

aaagatgtga agatagacct gtttgaaaga gaagaggtcg ggggccgcct ggctaccatg      300

atggtgcagg ggcaagaata cgaggcagga ggttctgtca tccatccttt aaatctgcac      360

atgaaacgtt ttgtcaaaga cctgggtctc tctgctgttc aggcctctgg tggcctactg      420

gggatatata atggagagac tctggtattt gaggagagca actggttcat aattaacgtg      480

attaaattag tttggcgcta tggatttcaa tccctccgta tgcacatgtg ggtagaggac      540

gtgttagaca agttcatgag gatctaccgc taccagtctc atgactatgc cttcagtagt      600

gtcgaaaaat tacttcatgc tctaggagga gatgacttcc ttggaatgct taatcgaaca      660

cttcttgaaa ccttgcaaaa ggccggcttt tctgagaagt tcctcaatga aatgattgct      720

cctgttatga gggtcaatta tggccaaagc acggacatca atgcctttgt gggggcggtg      780

tcactgtcct gttctgattc tggcctttgg gcagtagaag gtggcaataa acttgtttgc      840

tcagggcttc tgcaggcatc caaaagcaat cttatatctg gctcagtaat gtacatcgag      900

gagaaaacaa agaccaagta cacaggaaat ccaacaaaga tgtatgaagt ggtctaccaa      960

attggaactg agactcgttc agacttctat gacatcgtct tggtggccac tccgttgaat     1020

cgaaaaatgt cgaatattac ttttctcaac tttgatcctc caattgagga attccatcaa     1080

tattatcaac atatagtgac aactttagtt aagggggaat tgaatacatc tatctttagc     1140

tctagaccca tagataaatt tggccttaat acagttttaa ccactgataa ttcagatttg     1200

ttcattaaca gtattgggat tgtgccctct gtgagagaaa aggaagatcc tgagccatca     1260

acagatggaa catatgtttg gaagatcttt tcccaagaaa ctcttactaa agcacaaatt     1320

ttaaagctct ttctgtccta tgattatgct gtgaagaagc catggcttgc atatcctcac     1380

tataagcccc cggagaaatg cccctctatc attctccatg atcgacttta ttacctcaat     1440

ggcatagagt gtgcagcaag tgccatggag atgagtgcca ttgcagccca caacgctgca     1500

ctccttgcct atcaccgctg gaacgggcac acagacatga ttgatcagga tggcttatat     1560

gagaaactta aaactgaact atgaagtgac acactccttt ttcccctcct agttccaaat     1620

gactatcagt ggcaaaaaag aacaaaatct gagcagagat gattttgaac cagatatttt     1680

gccattatca ttgtttaata aaagtaatcc ctgctggtca taggaaaaca cacggttcta     1740

attaagtgtg aaggtatagc tattgcactt atgccatctc caaaatttct taagtattct     1800

ttcactatcc attaggagtt tttcttaaac ttgtctgata ataagaatca cctggagtta     1860

ggaggtggtg gttgcagtga gccaatctca ccattgcact tcagcctgag caacacgagc     1920

aaaactccgt ctcaaaagta aataaaaata atcacctgga gtttgttaaa ccatatggat     1980

tctcaagctc ctctcttgaa gattctgatt cagtaggtct gggagtggcg cgctggattt     2040

tgatcaaaat tgtagagcat tttaaggtga gtacctgagg gagaacttaa agacatctta     2100

gttggggagt agtccttttg aattttacag ctagatataa tcttcagtca gataaaattt     2160

atgggagctg gtgtcttatg cctgactctt agtaatttca taccggtttg aagtacgtgt     2220

gcccatgcct aaagccttga ctttcagaat gttgtctttt gattcttctg tcttgatttg     2280

attaggggtg aaatttagaa gtcttagtaa tgtaacttga agatgttaaa caaaaatctc     2340

aagtaaaatg aaaagcaaat atgggctact gaattaagaa actggcattc tagtattaaa     2400

tcctcacttc aggagctttt aaaaatactg agaccccccc ataaccagag attcagattc     2460

aaagactgag gataggacct tagcattgta gctatttaaa gtttctaatg tgcacccagg     2520

gttgggaatc accaatgtgg gtgtgaaaat gcctacaaag ggttttagtg ccttagaagt     2580

cctaagaagc ccaatctgta tcaaagcaga tccattttgc aaggatcttt cttttagaac     2640

tttctcagtt ctcttagtaa gaactttaga agtaatcttg ataataagca cagacagcct     2700

aacagcagag gcaacttaaa taactcctga gcagttggca ctagaacaga atacttggaa     2760

tgacaccaaa gttaaccaag tccagcatat gtccaaagag ttaagtgttt catttactgt     2820

agcattctgg gtgagaaatt ggttgctgaa atcttaagac agtggtctca accttggctg     2880

cacattggaa tcacctgtag ggttttaaag catccaaatg gtaattaaca ggcagcaaaa     2940

cttcagaact agttctgcat ctactgtgca aagatcatga ttaactgtca agacactggt     3000

agaacagaac aagcaaaaga ttaagagttc aaaagtaaat gcaaccaatt taacatgtag     3060

tgttattaaa aaattacaaa ggcctagacc agcctgggca acatggtgaa accccatctc     3120

tacaaaaaat ttttaaaaag ttggccaggc atggtaatgc gcgcctgtgg tcccagctgc     3180

tcgggaggct gaggtgggag gatcacttga gccttggagg tcaaggctgc agtgaatcat     3240

gatcatgcca ctgtactcca gcctgggcaa cagagaccat cttaaaaaaa aaaaatcctt     3300

ccattgaata gaaacttcaa agtccttcat cagatcatgg cattagctac tttagcaaaa     3360

tagtgtaaac tttggttctg agtaaaaatg acttcttccc taccacagtt gtgaatgtta     3420

atatgctgat aaaactgcca agatatattt gataggtagg ggattaaact catggtttgt     3480

caaaagagtg tttttttcta gttttattct taacagatat gttgaggtat tcatatttgt     3540

ttccttttgt ggttttaatg aagacaattt gtaaagtaat actgttatgt atatgctaaa     3600

tgttggtaaa tactaattaa tttccatcat ttgtagactt gttttgcaat gggatatatt     3660

tttacttata ataccaattt aggctgggcg cagtggctca cgcctgtaat cccagcactt     3720

tgggaggcca aggcaaacgg atcacgaggt caggagatca agaccatcct ggccaacatg     3780

gtgaaacccc atctctactg aatacacaaa aattggctgg acatggtggc gcatgtctgt     3840

aatcccagct actgtaatct cagctacttg ggaggctgag gcaggagaat tgcctcaacc     3900

gggaggcgga ggttgcagtg agccaagatc gcaccactgc actccagcct ggcaacagag     3960

cgagactctg tctcagaaaa aaaaaacaaa aaccagttta ggctgggtat ggtggctcac     4020

cagcactttg ggaggctgag gcaggtggat ctcttgaggt cgggagtttg agaccagcct     4080

ggccaacatg gtgaaaccct gtctttacta aaaatacaaa aattagccag gcatggtggc     4140

gtgtgccagt aatcccagct acttgggagg ctgaggcgcg agaatcgctt gaaccctgga     4200

gatggaggtt gcagtgagca gagatcgcac cactgcactc cagcctgggc aagagtgaga     4260

ctgtgtctca aaaggaaaaa aaaaaaatta aaaatgttgc tggtattaca tcaaacctac     4320

tctggataaa ttttccagta gggcatctga aattgctttg gcaaaagcaa aacaggttat     4380

caatacacca aggacatcaa gtagttttaa tgcaactaca gtgttgagtg cttttttact     4440

gggagaaaaa tcctagcaga acctgctact ctgggcgcat taggtagttt tatgcaacta     4500

tagtattaag agttttattg gaagaaaaaa cactgtcaga gcttactgct ccagaccttt     4560

ttttttaata gaagagactg gtaaaaatga tgcaggggct gaatgaaagc cagctctgct     4620

ccagtggctc tctgagttga gcatgcatca gttaccttaa gggcttgtta aaacatcgct     4680

aggctccacc ctgtttattc aataagtttg ttatgggata taagaagatg cattttatta     4740

agttccccag tgatgctgct gttctactat aggaaccaca cttgaagaac tagttctaca     4800

attcagctgt atgttgtaaa ggagtcaagt caatgaagga gttataaaga gttgctgaaa     4860

aatggagtaa cagtgtatgg gacttcacat cagttctcct tattgattgt tagtttgatc     4920

cctcttgttc ttttgttgta aacattttct ataattagga aatgccattt aagagtgaga     4980

gaggtatata tctatgagcc attgtgtttg gtgttttaca agaactttac catactggtg     5040

tgtagtccat tctgtacagt ttaaaagtga ttcacgattt gcaggctttt tatcagatca     5100

caaaaaaatc agtctttaag catttgcttg gtaaggtttc ttaagattag gtttataata     5160

caaccatctg taatgtatct ctcgtttgag cttgtgggcc atacaattca ttaactagat     5220

gaatacattg tggacagcat cctcactacc cctctctact cactcacaaa gaaccatgat     5280

acactggaat gtttttctct ggaatcctct ttctactctt gtattaaaat ttttccccac     5340

ttcatgatta tattcaaaat aaacaactac atcatta                              5377


<210>  3
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Arg Val Val Ala Glu Leu Val Ser Ser Leu Leu Gly Leu Trp 
1               5                   10                  15      


Leu Leu Leu Cys Ser Cys Gly Cys Pro Glu Gly Ala Glu Leu Arg Ala 
            20                  25                  30          


Pro Pro Asp Lys Ile Ala Ile Ile Gly Ala Gly Ile Gly Gly Thr Ser 
        35                  40                  45              


Ala Ala Tyr Tyr Leu Arg Gln Lys Phe Gly Lys Asp Val Lys Ile Asp 
    50                  55                  60                  


Leu Phe Glu Arg Glu Glu Val Gly Gly Arg Leu Ala Thr Met Met Val 
65                  70                  75                  80  


Gln Gly Gln Glu Tyr Glu Ala Gly Gly Ser Val Ile His Pro Leu Asn 
                85                  90                  95      


Leu His Met Lys Arg Phe Val Lys Asp Leu Gly Leu Ser Ala Val Gln 
            100                 105                 110         


Ala Ser Gly Gly Leu Leu Gly Ile Tyr Asn Gly Glu Thr Leu Val Phe 
        115                 120                 125             


Glu Glu Ser Asn Trp Phe Ile Ile Asn Val Ile Lys Leu Val Trp Arg 
    130                 135                 140                 


Tyr Gly Phe Gln Ser Leu Arg Met His Met Trp Val Glu Asp Val Leu 
145                 150                 155                 160 


Asp Lys Phe Met Arg Ile Tyr Arg Tyr Gln Ser His Asp Tyr Ala Phe 
                165                 170                 175     


Ser Ser Val Glu Lys Leu Leu His Ala Leu Gly Gly Asp Asp Phe Leu 
            180                 185                 190         


Gly Met Leu Asn Arg Thr Leu Leu Glu Thr Leu Gln Lys Ala Gly Phe 
        195                 200                 205             


Ser Glu Lys Phe Leu Asn Glu Met Ile Ala Pro Val Met Arg Val Asn 
    210                 215                 220                 


Tyr Gly Gln Ser Thr Asp Ile Asn Ala Phe Val Gly Ala Val Ser Leu 
225                 230                 235                 240 


Ser Cys Ser Asp Ser Gly Leu Trp Ala Val Glu Gly Gly Asn Lys Leu 
                245                 250                 255     


Val Cys Ser Gly Leu Leu Gln Ala Ser Lys Ser Asn Leu Ile Ser Gly 
            260                 265                 270         


Ser Val Met Tyr Ile Glu Glu Lys Thr Lys Thr Lys Tyr Thr Gly Asn 
        275                 280                 285             


Pro Thr Lys Met Tyr Glu Val Val Tyr Gln Ile Gly Thr Glu Thr Arg 
    290                 295                 300                 


Ser Asp Phe Tyr Asp Ile Val Leu Val Ala Thr Pro Leu Asn Arg Lys 
305                 310                 315                 320 


Met Ser Asn Ile Thr Phe Leu Asn Phe Asp Pro Pro Ile Glu Glu Phe 
                325                 330                 335     


His Gln Tyr Tyr Gln His Ile Val Thr Thr Leu Val Lys Gly Glu Leu 
            340                 345                 350         


Asn Thr Ser Ile Phe Ser Ser Arg Pro Ile Asp Lys Phe Gly Leu Asn 
        355                 360                 365             


Thr Val Leu Thr Thr Asp Asn Ser Asp Leu Phe Ile Asn Ser Ile Gly 
    370                 375                 380                 


Ile Val Pro Ser Val Arg Glu Lys Glu Asp Pro Glu Pro Ser Thr Asp 
385                 390                 395                 400 


Gly Thr Tyr Val Trp Lys Ile Phe Ser Gln Glu Thr Leu Thr Lys Ala 
                405                 410                 415     


Gln Ile Leu Lys Leu Phe Leu Ser Tyr Asp Tyr Ala Val Lys Lys Pro 
            420                 425                 430         


Trp Leu Ala Tyr Pro His Tyr Lys Pro Pro Glu Lys Cys Pro Ser Ile 
        435                 440                 445             


Ile Leu His Asp Arg Leu Tyr Tyr Leu Asn Gly Ile Glu Cys Ala Ala 
    450                 455                 460                 


Ser Ala Met Glu Met Ser Ala Ile Ala Ala His Asn Ala Ala Leu Leu 
465                 470                 475                 480 


Ala Tyr His Arg Trp Asn Gly His Thr Asp Met Ile Asp Gln Asp Gly 
                485                 490                 495     


Leu Tyr Glu Lys Leu Lys Thr Glu Leu 
            500                 505 


<210>  4
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  4

Tyr Gln Ser His Asp Tyr Ala Phe Ser Ser Val Glu Lys 
1               5                   10              


<210>  5
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Cysteine is carbamidomethylated

<400>  5

Leu Val Cys Ser Gly Leu Leu Gln Ala Ser Lys 
1               5                   10      


<210>  6
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hairpin sequence:

<400>  6
gatccggaaa gatgtgaaga tagattcaag agatctatct tcacatcttt ccttttt          57


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  7
ggaaagaugu gaagauagat t                                                 21


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  8
ucuaucuuca caucuuucct t                                                 21


<210>  9
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hairpin sequence

<400>  9
gatccccact ccgttgaatc gaaattcaag agatttcgat tcaacggagt ggttttt          57


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  10
ccacuccguu gaaucgaaat t                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  11
uuucgauuca acggaguggt t                                                 21


<210>  12
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hairpin sequence

<400>  12
gatccgaagc ccaatctgta tcaattcaag agattgatac agattgggct tcttttt          57


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  13
gaagcccaau cuguaucaat t                                                 21


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  14
uugauacaga uugggcuuct t                                                 21


<210>  15
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y-13-K heavy peptide


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  (13C6; 15N2)

<400>  15

Tyr Gln Ser His Asp Tyr Ala Phe Ser Ser Val Glu Lys 
1               5                   10              


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-11-R heavy peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Cysteine is carbamidomethylated

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  (13C6; 15N2)

<400>  16

Leu Val Cys Ser Gly Leu Leu Gln Ala Ser Lys 
1               5                   10      


