                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
       NOVINA , Carl
       MEISTER , Glenna
       OSTERMEIER , Marc
       XIONG , Tina
 
<120>  SYSTEMS AND METHODS FOR GENOME MODIFICATION AND REGULATION

<130>  DFCI-098/001WO

<150>  US 62/096,766
<151>  2014-12-24

<150>  US62/143,080
<151>  2015-04-04

<150>  US62/186,862
<151>  2015-06-30

<160>  1     

<170>  PatentIn version 3.5

<210>  1
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  1

Met Ser Lys Val Glu Asn Lys Thr Lys Lys Leu Arg Val Phe Glu Ala 
1               5                   10                  15      


Phe Ala Gly Ile Gly Ala Gln Arg Lys Ala Leu Glu Lys Val Arg Lys 
            20                  25                  30          


Asp Glu Tyr Glu Ile Val Gly Leu Ala Glu Trp Tyr Val Pro Ala Ile 
        35                  40                  45              


Val Met Tyr Gln Ala Ile His Asn Asn Phe His Thr Lys Leu Glu Tyr 
    50                  55                  60                  


Lys Ser Val Ser Arg Glu Glu Met Ile Asp Tyr Leu Glu Asn Lys Thr 
65                  70                  75                  80  


Leu Ser Trp Asn Ser Lys Asn Pro Val Ser Asn Gly Tyr Trp Lys Arg 
                85                  90                  95      


Lys Lys Asp Asp Glu Leu Lys Ile Ile Tyr Asn Ala Ile Lys Leu Ser 
            100                 105                 110         


Glu Lys Glu Gly Asn Ile Phe Asp Ile Arg Asp Leu Tyr Lys Arg Thr 
        115                 120                 125             


Leu Lys Asn Ile Asp Leu Leu Thr Tyr Ser Phe Pro Cys Gln Asp Leu 
    130                 135                 140                 


Ser Gln Gln Gly Ile Gln Lys Gly Met Lys Arg Gly Ser Gly Thr Arg 
145                 150                 155                 160 


Ser Gly Leu Leu Trp Glu Ile Glu Arg Ala Leu Asp Ser Thr Glu Lys 
                165                 170                 175     


Asn Asp Leu Pro Lys Tyr Leu Leu Met Glu Asn Val Gly Ala Leu Leu 
            180                 185                 190         


His Lys Lys Asn Glu Glu Glu Leu Asn Gln Trp Lys Gln Lys Leu Glu 
        195                 200                 205             


Ser Leu Gly Tyr Gln Asn Ser Ile Glu Val Leu Asn Ala Ala Asp Phe 
    210                 215                 220                 


Gly Ser Ser Gln Ala Arg Arg Arg Val Phe Met Ile Ser Thr Leu Asn 
225                 230                 235                 240 


Glu Phe Val Glu Leu Pro Lys Gly Asp Lys Lys Pro Lys Ser Ile Lys 
                245                 250                 255     


Lys Val Leu Asn Lys Ile Val Ser Glu Lys Asp Ile Leu Asn Asn Leu 
            260                 265                 270         


Leu Lys Tyr Asn Leu Thr Glu Phe Lys Lys Thr Lys Ser Asn Ile Asn 
        275                 280                 285             


Lys Ala Ser Leu Ile Gly Tyr Ser Lys Phe Asn Ser Glu Gly Tyr Val 
    290                 295                 300                 


Tyr Asp Pro Glu Phe Thr Gly Pro Thr Leu Thr Ala Ser Gly Ala Asn 
305                 310                 315                 320 


Ser Arg Ile Lys Ile Lys Asp Gly Ser Asn Ile Arg Lys Met Asn Ser 
                325                 330                 335     


Asp Glu Thr Phe Leu Tyr Met Gly Phe Asp Ser Gln Asp Gly Lys Arg 
            340                 345                 350         


Val Asn Glu Ile Glu Phe Leu Thr Glu Asn Gln Lys Ile Phe Val Cys 
        355                 360                 365             


Gly Asn Ser Ile Ser Val Glu Val Leu Glu Ala Ile Ile Asp Lys Ile 
    370                 375                 380                 


Gly Gly 
385     


