                               SEQUENCE LISTING

<110> GUANGZHOU RIBOBIO CO., LTD.
      GUANGZHOU INSTITUTE OF BIOMEDICINE AND HEALTH, 
      CHINESE ACADEMY OF SCIENCES
 
<120> COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF ADAMTS-5 
      AND ADAM17

<130> 13091.0001-00304

<140>
<141>

<150> CN 201410828587.5
<151> 2014-12-25

<150> CN 201410827650.3
<151> 2014-12-25

<160> 198   

<170> PatentIn version 3.5

<210> 1
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
ggauuuaugu gggcaucau                                                    19


<210> 2
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
augaugccca cauaaaucc                                                    19


<210> 3
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 3
ggauuuaugu gggcaucaut t                                                 21


<210> 4
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 4
augaugccca cauaaaucct t                                                 21


<210> 5
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
agctaaaaaa tgatgcccac ataaatcctc tcttgaagga tttatgtggg catcatggg        59


<210> 6
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
gatccccatg atgcccacat aaatccttca agagaggatt tatgtgggca tcatttttt        59


<210> 7
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
gcaucaugua ucugaacaa                                                    19


<210> 8
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
uuguucagau acaugaugc                                                    19


<210> 9
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 9
gcaucaugua ucugaacaat t                                                 21


<210> 10
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 10
uuguucagau acaugaugct t                                                 21


<210> 11
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
agctaaaaat tgttcagata catgatgctc tcttgaagca tcatgtatct gaacaaggg        59


<210> 12
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
gatccccttg ttcagataca tgatgcttca agagagcatc atgtatctga acaattttt        59


<210> 13
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> May be 5'-Cholesterol modified

<220>
<221> modified_base
<222> (1)..(3)
<223> May be 2'-O-methyl modified deoxyribonucleotide 

<220>
<221> modified_base
<222> (17)..(18)
<223> May be 2'-O-methyl modified deoxyribonucleotide 

<220>
<221> modified_base
<222> (19)..(19)
<223> May be 2'-O-methyl modified ribonucleotide 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 13
ggauuuaugu gggcaucaut t                                                 21


<210> 14
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> May 5'-phosphorylated

<220>
<221> modified_base
<222> (1)..(1) 
<223> May be 2'-O-methyl modified deoxyribonucleotide 

<220>
<221> modified_base
<222> (2)..(2) 
<223> May be 2'-O-methyl modified ribonucleotide 

<220>
<221> modified_base
<222> (3)..(3) 
<223> May be 2'-O-methyl modified deoxyribonucleotide 

<220>
<221> modified_base
<222> (17)..(17)
<223> May be 2'-O-methyl modified ribonucleotide 

<220>
<221> modified_base
<222> (18)..(19)
<223> May be 2'-O-methyl modified deoxyribonucleotide 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 14
augaugccca cauaaaucct t                                                 21


<210> 15
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> May be 5'-Cholesterol modified

<220>
<221> modified_base
<222> (1)..(3)
<223> May be 2'-O-methyl modified deoxyribonucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> May be 2'-O-methyl modified deoxyribonucleotide 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 15
gcaucaugua ucugaacaat t                                                 21


<210> 16
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> May 5'-phosphorylated

<220>
<221> modified_base
<222> (1)..(2) 
<223> May be 2'-O-methyl modified ribonucleotide 

<220>
<221> modified_base
<222> (3)..(3) 
<223> May be 2'-O-methyl modified deoxyribonucleotide 

<220>
<221> modified_base
<222> (17)..(17)
<223> May be 2'-O-methyl modified ribonucleotide 

<220>
<221> modified_base
<222> (18)..(19)
<223> May be 2'-O-methyl modified deoxyribonucleotide 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 16
uuguucagau acaugaugct t                                                 21


<210> 17
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
auuuaugugg gcauc                                                        15


<210> 18
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
uuaugugggc a                                                            11


<210> 19
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
ggauuuaugu gggcaucauu cau                                               23


<210> 20
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
ggauuuaugu gggcaucauu cauguga                                           27


<210> 21
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
ggacuaguuu augugggcau cau                                               23


<210> 22
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
gcuguuaugu gggcaucau                                                    19


<210> 23
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
gguuauaugu gggcaucau                                                    19


<210> 24
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
ggauuuaugu aggcaucau                                                    19


<210> 25
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
gcuguaaugu aggcaucau                                                    19


<210> 26
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
aaguccuugu gggcaucau                                                    19


<210> 27
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
auuaaugugg gcauc                                                        15


<210> 28
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
caguuuaugu gggca                                                        15


<210> 29
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
gaugcccaca uaaau                                                        15


<210> 30
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
ugcccacaua a                                                            11


<210> 31
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
augaaugaug cccacauaaa ucc                                               23


<210> 32
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
ucacaugaau gaugcccaca uaaaucc                                           27


<210> 33
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 33
augggucaug cccacauaaa ucc                                               23


<210> 34
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 34
augaugccca cauagauuc                                                    19


<210> 35
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
augaugccca cauaccauc                                                    19


<210> 36
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 36
augaugccca cauaccacc                                                    19


<210> 37
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 37
augaugccca cagaccauc                                                    19


<210> 38
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 38
augaugccca cauacaucc                                                    19


<210> 39
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 39
acgaugccca caugca                                                       16


<210> 40
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 40
uuaugugggc att                                                          13


<210> 41
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 41
ggauuuaugu gggcaucauu caugugatt                                         29


<210> 42
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 42
ucgggaggau uuaugugggc aucau                                             25


<210> 43
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 43
ggauuuaugu gggcaucaua guaca                                             25


<210> 44
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 44
ggauuuaugu gggcaucaua guaca                                             25


<210> 45
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 45
ugcccacaua att                                                          13


<210> 46
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 46
ucacaugaau gaugcccaca uaaaucctt                                         29


<210> 47
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 47
augaugccca cauaaauccu cccga                                             25


<210> 48
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 48
uguacuauga ugcccacaua aauccag                                           27


<210> 49
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 49
uguacuauga ugcccacaua aauccuu                                           27


<210> 50
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(4)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> misc_feature
<222> (17)..(20)
<223> Phosphorothioate linkage between nucleotides 

<400> 50
ggauuuaugu gggcaucaut t                                                 21


<210> 51
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(4)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> misc_feature
<222> (17)..(20)
<223> Phosphorothioate linkage between nucleotides 

<400> 51
augaugccca cauaaaucct t                                                 21


<210> 52
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5'-Chol modified

<400> 52
ggauuuaugu gggcaucaut t                                                 21


<210> 53
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 53
augaugccca cauaaaucct t                                                 21


<210> 54
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide

<400> 54
ggauuuaugu gggcaucaut t                                                 21


<210> 55
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide

<400> 55
augaugccca cauaaaucct t                                                 21


<210> 56
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-F modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-F modified nucleotide 

<400> 56
ggauuuaugu gggcaucaut t                                                 21


<210> 57
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-F modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-F modified nucleotide 

<400> 57
augaugccca cauaaaucct t                                                 21


<210> 58
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 58
ggauuuaugu gggcaucaut t                                                 21


<210> 59
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> LNA modified 

<220>
<221> modified_base
<222> (17)..(19)
<223> LNA modified 

<400> 59
augaugccca cauaaaucct t                                                 21


<210> 60
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 60
ggauuuaugu gggcaucaut t                                                 21


<210> 61
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> UNA modified

<400> 61
augaugccca cauaaaucct t                                                 21


<210> 62
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> Indole modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> Indole modified nucleotide 

<400> 62
ggauuuaugu gggcaucaut t                                                 21


<210> 63
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> Indole modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> Indole modified nucleotide 

<400> 63
augaugccca cauaaaucct t                                                 21


<210> 64
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (14)..(14)
<223> 5-methylcytosine 

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methylcytosine 

<400> 64
ggauuuaugu gggcaucaut t                                                 21


<210> 65
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (7)..(7)
<223> 5-methylcytosine 

<220>
<221> modified_base
<222> (18)..(19)
<223> 5-methylcytosine 

<400> 65
augaugccca cauaaaucct t                                                 21


<210> 66
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (4)..(6)
<223> 5-ethynyluracil 

<220>
<221> modified_base
<222> (16)..(16)
<223> 5-ethynyluracil 

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-ethynyluracil 

<400> 66
ggauuuaugu gggcaucaut t                                                 21


<210> 67
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-ethynyluracil 

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-ethynyluracil 

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-ethynyluracil 

<400> 67
augaugccca cauaaaucct t                                                 21


<210> 68
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<220>
<223> 3'-galactose modified

<400> 68
ggauuuaugu gggcaucaut t                                                 21


<210> 69
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<400> 69
augaugccca cauaaaucct t                                                 21


<210> 70
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<400> 70
ggauuuaugu gggcaucaut t                                                 21


<210> 71
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5'-phosphorylated

<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<400> 71
augaugccca cauaaaucct t                                                 21


<210> 72
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5' may be modified by a polypeptide

<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<400> 72
ggauuuaugu gggcaucaut t                                                 21


<210> 73
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<400> 73
augaugccca cauaaaucct t                                                 21


<210> 74
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5'-Cy modified

<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<400> 74
ggauuuaugu gggcaucaut t                                                 21


<210> 75
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5'-phosphorylated

<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<400> 75
augaugccca cauaaaucct t                                                 21


<210> 76
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (1)..(4)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (17)..(20)
<223> Phosphorothioate linkage between nucleotides 

<400> 76
ggauuuaugu gggcaucaut t                                                 21


<210> 77
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (1)..(4)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (17)..(20)
<223> Phosphorothioate linkage between nucleotides 

<400> 77
augaugccca cauaaaucct t                                                 21


<210> 78
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5'-Chol modified

<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<400> 78
ggauuuaugu gggcaucaut t                                                 21


<210> 79
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<400> 79
augaugccca cauaaaucct t                                                 21


<210> 80
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5'-Chol modified

<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<400> 80
ggauuuaugu gggcaucaut t                                                 21


<210> 81
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5'-phosphorylated

<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<400> 81
augaugccca cauaaaucct t                                                 21


<210> 82
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5'-Chol modified

<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (1)..(4)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (17)..(20)
<223> Phosphorothioate linkage between nucleotides 

<400> 82
ggauuuaugu gggcaucaut t                                                 21


<210> 83
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5'-phosphorylated

<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (1)..(4)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (17)..(20)
<223> Phosphorothioate linkage between nucleotides 

<400> 83
augaugccca cauaaaucct t                                                 21


<210> 84
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (14)..(14) 
<223> 5-methylcytosine 

<220>
<221> modified_base
<222> (17)..(17) 
<223> 5-methylcytosine 

<400> 84
ggauuuaugu gggcaucaut t                                                 21


<210> 85
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (7)..(7) 
<223> 5-methylcytosine 

<220>
<221> modified_base
<222> (18)..(19) 
<223> 5-methylcytosine 

<400> 85
augaugccca cauaaaucct t                                                 21


<210> 86
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5'-Biotin modified

<220>
<221> modified_base
<222> (1)..(2)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (18)..(19)
<223> 2'-OMe modified nucleotide 

<400> 86
ggauuuaugu gggcaucaut t                                                 21


<210> 87
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(2)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (18)..(19)
<223> 2'-OMe modified nucleotide 

<400> 87
augaugccca cauaaaucct t                                                 21


<210> 88
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(2)
<223> 2'-F modified nucleotide 

<220>
<221> modified_base
<222> (19)..(20)
<223> 2'-OMe modified nucleotide 

<400> 88
ggauuuaugu gggcaucauu                                                   20


<210> 89
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(2)
<223> 2'-F modified nucleotide 

<220>
<221> modified_base
<222> (19)..(20)
<223> 2'-OMe modified nucleotide 

<400> 89
aaugaugccc acauaaaucc                                                   20


<210> 90
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1) 
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (2)..(2) 
<223> 2'-F modified nucleotide 

<220>
<221> modified_base
<222> (18)..(18) 
<223> 2'-F modified nucleotide 

<220>
<221> modified_base
<222> (19)..(19) 
<223> 2'-OMe modified nucleotide 

<400> 90
ggauuuaugu gggcaucau                                                    19


<210> 91
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1) 
<223> 2'-F modified nucleotide 

<220>
<221> modified_base
<222> (2)..(2) 
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (18)..(18) 
<223> 2'-F modified nucleotide 

<220>
<221> modified_base
<222> (19)..(19) 
<223> 2'-OMe modified nucleotide 

<400> 91
augaugccca cauaaaucc                                                    19


<210> 92
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage between nucleotides 

<400> 92
ggauuuaugu gggcaucaut t                                                 21


<210> 93
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage between nucleotides 

<400> 93
augaugccca cauaaaucct t                                                 21


<210> 94
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate linkage between nucleotides 

<400> 94
ggauuuaugu gggcaucau                                                    19


<210> 95
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage between nucleotides 

<400> 95
augaugccca cauaaauccu c                                                 21


<210> 96
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 3'-Chol modified

<400> 96
ggauuuaugu gggcaucaut t                                                 21


<210> 97
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 97
augaugccca cauaaaucct t                                                 21


<210> 98
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 98
cauguaucug a                                                            11


<210> 99
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 99
aucauguauc ugaac                                                        15


<210> 100
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 100
uggcaucaug uaucugaaca acg                                               23


<210> 101
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 101
ccuggcauca uguaucugaa caacgac                                           27


<210> 102
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 102
gcaagcauca uguaucugaa caa                                               23


<210> 103
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 103
gucacaugua ucugaacaa                                                    19


<210> 104
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 104
gcgucgugua ucugaacaa                                                    19


<210> 105
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 105
gcaucaugua gcugaacaa                                                    19


<210> 106
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 106
gucagaugua gcugaacaa                                                    19


<210> 107
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 107
aucuggagua ucugaacaa                                                    19


<210> 108
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 108
aucguguauc ugaac                                                        15


<210> 109
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 109
gcaucaugua ccugaacaa                                                    19


<210> 110
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 110
cugacgucau guaucugguc                                                   20


<210> 111
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 111
ucagauacau g                                                            11


<210> 112
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 112
guucagauac augau                                                        15


<210> 113
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 113
gucguuguuc agauacauga ugc                                               23


<210> 114
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 114
gucguuguuc agauacauga ugccagg                                           27


<210> 115
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 115
uugucuauuc agauacauga ugc                                               23


<210> 116
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 116
uuguucagau acaucauac                                                    19


<210> 117
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 117
uuguucagau acauccaac                                                    19


<210> 118
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 118
uuguucagau acauccagc                                                    19


<210> 119
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 119
uuguucagau acguccaac                                                    19


<210> 120
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 120
uuguucagau acgucaugc                                                    19


<210> 121
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 121
gcucagauac auggcac                                                      17


<210> 122
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 122
cauguaucug att                                                          13


<210> 123
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 123
ccuggcauca uguaucugaa caacgactt                                         29


<210> 124
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 124
guucguguau cugaacaa                                                     18


<210> 125
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 125
gucagaugua ucugaacaa                                                    19


<210> 126
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 126
ucagauacau gtt                                                          13


<210> 127
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 127
gucguuguuc agauacauga ugccaggtt                                         29


<210> 128
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 128
uuguucaggu acaugaugc                                                    19


<210> 129
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(4)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> misc_feature
<222> (17)..(20)
<223> Phosphorothioate linkage between nucleotides 

<400> 129
gcaucaugua ucugaacaat t                                                 21


<210> 130
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(4)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> misc_feature
<222> (17)..(20)
<223> Phosphorothioate linkage between nucleotides 

<400> 130
uuguucagau acaugaugct t                                                 21


<210> 131
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5'-Chol modified

<400> 131
gcaucaugua ucugaacaat t                                                 21


<210> 132
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 132
uuguucagau acaugaugct t                                                 21


<210> 133
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<400> 133
gcaucaugua ucugaacaat t                                                 21


<210> 134
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<400> 134
uuguucagau acaugaugct t                                                 21


<210> 135
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-F modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-F modified nucleotide 

<400> 135
gcaucaugua ucugaacaat t                                                 21


<210> 136
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-F modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-F modified nucleotide 

<400> 136
uuguucagau acaugaugct t                                                 21


<210> 137
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 137
gcaucaugua ucugaacaat t                                                 21


<210> 138
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> LNA modified 

<220>
<221> modified_base
<222> (17)..(19)
<223> LNA modified 

<400> 138
uuguucagau acaugaugct t                                                 21


<210> 139
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 139
gcaucaugua ucugaacaat t                                                 21


<210> 140
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> UNA modified

<400> 140
uuguucagau acaugaugct t                                                 21


<210> 141
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> Indole modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> Indole modified nucleotide 

<400> 141
gcaucaugua ucugaacaat t                                                 21


<210> 142
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> Indole modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> Indole modified nucleotide 

<400> 142
uuguucagau acaugaugct t                                                 21


<210> 143
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (2)..(2)
<223> 5-methylcytosine 

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methylcytosine 

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-methylcytosine 

<400> 143
gcaucaugua ucugaacaat t                                                 21


<210> 144
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methylcytosine 

<220>
<221> modified_base
<222> (19)..(19)
<223> 5-methylcytosine 

<400> 144
uuguucagau acaugaugct t                                                 21


<210> 145
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (4)..(4)
<223> 5-ethynyluracil 

<400> 145
gcaucaugua ucugaacaat t                                                 21


<210> 146
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(2)
<223> 5-ethynyluracil 

<220>
<221> modified_base
<222> (4)..(5)
<223> 5-ethynyluracil 

<220>
<221> modified_base
<222> (14)..(14)
<223> 5-ethynyluracil 

<220>
<221> modified_base
<222> (17)..(17)
<223> 5-ethynyluracil 

<400> 146
uuguucagau acaugaugct t                                                 21


<210> 147
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<220>
<223> 3'-galactose

<400> 147
gcaucaugua ucugaacaat t                                                 21


<210> 148
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<400> 148
uuguucagau acaugaugct t                                                 21


<210> 149
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<400> 149
gcaucaugua ucugaacaat t                                                 21


<210> 150
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5'-phosphorylated

<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<400> 150
uuguucagau acaugaugct t                                                 21


<210> 151
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5' may be modified by a polypeptide

<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<400> 151
gcaucaugua ucugaacaat t                                                 21


<210> 152
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<400> 152
uuguucagau acaugaugct t                                                 21


<210> 153
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5'-Cy modified

<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<400> 153
gcaucaugua ucugaacaat t                                                 21


<210> 154
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<400> 154
uuguucagau acaugaugct t                                                 21


<210> 155
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (1)..(4)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (17)..(20)
<223> Phosphorothioate linkage between nucleotides 

<400> 155
gcaucaugua ucugaacaat t                                                 21


<210> 156
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (1)..(4)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (17)..(20)
<223> Phosphorothioate linkage between nucleotides 

<400> 156
uuguucagau acaugaugct t                                                 21


<210> 157
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5'-Chol modified

<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<400> 157
gcaucaugua ucugaacaat t                                                 21


<210> 158
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<400> 158
uuguucagau acaugaugct t                                                 21


<210> 159
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5'-Chol modified

<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<400> 159
gcaucaugua ucugaacaat t                                                 21


<210> 160
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5'-phosphorylated

<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<400> 160
uuguucagau acaugaugct t                                                 21


<210> 161
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5'-Chol modified

<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (1)..(4)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (17)..(20)
<223> Phosphorothioate linkage between nucleotides 

<400> 161
gcaucaugua ucugaacaat t                                                 21


<210> 162
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5'-phosphorylated

<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (1)..(4)
<223> Phosphorothioate linkage between nucleotides 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (17)..(20)
<223> Phosphorothioate linkage between nucleotides 

<400> 162
uuguucagau acaugaugct t                                                 21


<210> 163
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1) 
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (2)..(2) 
<223> 5-methylcytosine 

<220>
<221> modified_base
<222> (3)..(3) 
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (5)..(5)
<223> 5-methylcytosine 

<220>
<221> modified_base
<222> (17)..(17) 
<223> 5-methylcytosine 

<220>
<221> modified_base
<222> (18)..(18) 
<223> 2'-OMe modified nucleotide 

<400> 163
gcaucaugua ucugaacaat t                                                 21


<210> 164
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (6)..(6)
<223> 5-methylcytosine 

<220>
<221> modified_base
<222> (17)..(18)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (19)..(19) 
<223> 5-methylcytosine 

<400> 164
uuguucagau acaugaugct t                                                 21


<210> 165
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<223> 5'-biotin modified

<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-OMe modified nucleotide 

<400> 165
gcaucaugua ucugaacaat t                                                 21


<210> 166
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<400> 166
uuguucagau acaugaugct t                                                 21


<210> 167
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 167
gcaucaugua ucugaacaa                                                    19


<210> 168
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-F modified nucleotide 

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-OMe modified nucleotide 

<400> 168
uuguucagau acaugaugc                                                    19


<210> 169
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1) 
<223> 2'-F modified nucleotide 

<220>
<221> modified_base
<222> (2)..(2) 
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (3)..(3) 
<223> 2'-F modified nucleotide 

<220>
<221> modified_base
<222> (4)..(4) 
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-F modified nucleotide 

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-F modified nucleotide 

<400> 169
gcaucaugua ucugaacaa                                                    19


<210> 170
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-F modified nucleotide 

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-F modified nucleotide 

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-F modified nucleotide 

<220>
<221> modified_base
<222> (18)..(18)
<223> 2'-F modified nucleotide 

<400> 170
uuguucagau acaugaugc                                                    19


<210> 171
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage between nucleotides 

<400> 171
gcaucaugua ucugaacaat t                                                 21


<210> 172
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage between nucleotides 

<400> 172
uuguucagau acaugaugct t                                                 21


<210> 173
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(2)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (17)..(17)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (18)..(19)
<223> Phosphorothioate linkage between nucleotides 

<400> 173
gcaucaugua ucugaacaa                                                    19


<210> 174
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-OMe modified nucleotide 

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-OMe modified nucleotide 

<220>
<221> misc_feature
<222> (20)..(21)
<223> Phosphorothioate linkage between nucleotides 

<400> 174
uuguucagau acaugaugcc a                                                 21


<210> 175
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 175
agaucguuag uuagguugct t                                                 21


<210> 176
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 176
gcaaccuaac uaacgaucut t                                                 21


<210> 177
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 177
ctgctcccag aaacaacg                                                     18


<210> 178
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 178
attcagtgcc atcggtca                                                     18


<210> 179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 179
cgagtgacaa gcctgtagcc                                                   20


<210> 180
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 180
tgaagaggac ctgggagtag at                                                22


<210> 181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 181
cagggttgct ggtggtagga                                                   20


<210> 182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 182
gcataaagcg tttgcggtac                                                   20


<210> 183
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 183
acgaatctcc gaccacca                                                     18


<210> 184
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 184
ggaccagaca tcaccaagc                                                    19


<210> 185
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 185
aguaugccac auaagcauct t                                                 21


<210> 186
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 186
gaugcuuaug uggcauacut t                                                 21


<210> 187
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 187
ggaccaggga gggaaata                                                     18


<210> 188
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 188
gttgcagcag gtgtcgtt                                                     18


<210> 189
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 189
uucuccgaac gugucacgut t                                                 21


<210> 190
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 190
acgugacacg uucggagaat t                                                 21


<210> 191
<211> 9663
<212> DNA
<213> Homo sapiens

<400> 191
ataaattcat tgttccacct cctcgcatct tcacagcgct cgcgctgctc tcggcgctcg       60

cagctgccga ctggggatga cggcgggcag gaggagaccg cagccgaagg gacacagaca      120

cgccgcttca ccagctcgcc tcaggctgcc cccctgcatt tttgttttaa tttttacggc      180

tttttcccct ctctttcttc ccttcctcct ggtcccagca gagccaagga aacccacaaa      240

ataagaaagg aagtgggccc cggagcttgg aacctccaca gccggcttgt ccagcgcagc      300

gcgggggcgg gaggctgcgc gcaccagttg ccagcccggt gcgcggtacc tttccttact      360

tttcttgaaa cagcgatcgt gcctgcattt ggtggttttt tggtttttgt ttttttcctt      420

ttcccgtatt tgctgaatct ccactatccg actttttttt tttaatcttt tctttccccc      480

cccccccacc ccacctcttt ctggagcacg aatccaaaca ttttcccaag caacaaagaa      540

aagttcgcac gctggcaccg cagcccggac aggctggcgc tgctgccggg cccccctccc      600

tccgacactt gactcaatcc tgcaagcaag tgtgtgtgtg tccccatccc ccgccccgtt      660

aacttcatag caaataacaa atacccataa agtcccagtc gcgcagcccc tccccgcggg      720

cagcgcacta tgctgctcgg gtgggcgtcc ctgctgctgt gcgcgttccg cctgcccctg      780

gccgcggtcg gccccgccgc gacacctgcc caggataaag ccgggcagcc tccgactgct      840

gcagcagccg cccagccccg ccggcggcag ggggaggagg tgcaggagcg agccgagcct      900

cccggccacc cgcaccccct ggcgcagcgg cgcaggagca aggggctggt gcagaacatc      960

gaccaactct actccggcgg cggcaaggtg ggctacctcg tctacgcggg cggccggagg     1020

ttcctcttgg acctggagcg agatggttcg gtgggcattg ctggcttcgt gcccgcagga     1080

ggcgggacga gtgcgccctg gcgccaccgg agccactgct tctatcgggg cacagtggac     1140

ggtagtcccc gctctctggc tgtctttgac ctctgtgggg gtctcgacgg cttcttcgcg     1200

gtcaagcacg cgcgctacac cctaaagcca ctgctgcgcg gaccctgggc ggaggaagaa     1260

aaggggcgcg tgtacgggga tgggtccgca cggatcctgc acgtctacac ccgcgagggc     1320

ttcagcttcg aggccctgcc gccgcgcgcc agctgcgaaa cccccgcgtc cacaccggag     1380

gcccacgagc atgctccggc gcacagcaac ccgagcggac gcgcagcact ggcctcgcag     1440

ctcttggacc agtccgctct ctcgcccgct gggggctcag gaccgcagac gtggtggcgg     1500

cggcggcgcc gctccatctc ccgggcccgc caggtggagc tgcttctggt ggctgacgcg     1560

tccatggcgc ggttgtatgg ccggggcctg cagcattacc tgctgaccct ggcctccatc     1620

gccaataggc tgtacagcca tgctagcatc gagaaccaca tccgcctggc cgtggtgaag     1680

gtggtggtgc taggcgacaa ggacaagagc ctggaagtga gcaagaacgc tgccaccaca     1740

ctcaagaact tttgcaagtg gcagcaccaa cacaaccagc tgggagatga ccatgaggag     1800

cactacgatg cagctatcct gtttactcgg gaggatttat gtgggcatca ttcatgtgac     1860

accctgggaa tggcagacgt tgggaccata tgttctccag agcgcagctg tgctgtgatt     1920

gaagacgatg gcctccacgc agccttcact gtggctcacg aaatcggaca tttacttggc     1980

ctctcccatg acgattccaa attctgtgaa gagacctttg gttccacaga agataagcgc     2040

ttaatgtctt ccatccttac cagcattgat gcatctaagc cctggtccaa atgcacttca     2100

gccaccatca cagaattcct ggatgatggc catggtaact gtttgctgga cctaccacga     2160

aagcagatcc tgggccccga agaactccca ggacagacct acgatgccac ccagcagtgc     2220

aacctgacat tcgggcctga gtactccgtg tgtcccggca tggatgtctg tgctcgcctg     2280

tggtgtgctg tggtacgcca gggccagatg gtctgtctga ccaagaagct gcctgcggtg     2340

gaagggacgc cttgtggaaa ggggagaatc tgcctgcagg gcaaatgtgt ggacaaaacc     2400

aagaaaaaat attattcaac gtcaagccat ggcaactggg gatcttgggg atcctggggc     2460

cagtgttctc gctcatgtgg aggaggagtg cagtttgcct atcgtcactg taataaccct     2520

gctcccagaa acaacggacg ctactgcaca gggaagaggg ccatctaccg ctcctgcagt     2580

ctcatgccct gcccacccaa tggtaaatca tttcgtcatg aacagtgtga ggccaaaaat     2640

ggctatcagt ctgatgcaaa aggagtcaaa acttttgtgg aatgggttcc caaatatgca     2700

ggtgtcctgc cagcggatgt gtgcaagctg acctgcagag ccaagggcac tggctactat     2760

gtggtatttt ctccaaaggt gaccgatggc actgaatgta ggctgtacag taattccgtc     2820

tgcgtccggg ggaagtgtgt gagaactggc tgtgacggca tcattggctc aaagctgcag     2880

tatgacaagt gcggagtatg tggaggagac aactccagct gtacaaagat tgttggaacc     2940

tttaataaga aaagtaaggg ttacactgac gtggtgagga ttcctgaagg ggcaacccac     3000

ataaaagttc gacagttcaa agccaaagac cagactagat tcactgccta tttagccctg     3060

aaaaagaaaa acggtgagta ccttatcaat ggaaagtaca tgatctccac ttcagagact     3120

atcattgaca tcaatggaac agtcatgaac tatagcggtt ggagccacag ggatgacttc     3180

ctgcatggca tgggctactc tgccacgaag gaaattctaa tagtgcagat tcttgcaaca     3240

gaccccacta aaccattaga tgtccgttat agcttttttg ttcccaagaa gtccactcca     3300

aaagtaaact ctgtcactag tcatggcagc aataaagtgg gatcacacac ttcgcagccg     3360

cagtgggtca cgggcccatg gctcgcctgc tctaggacct gtgacacagg ttggcacacc     3420

agaacggtgc agtgccagga tggaaaccgg aagttagcaa aaggatgtcc tctctcccaa     3480

aggccttctg cgtttaagca atgcttgttg aagaaatgtt agcctgtggt tatgatctta     3540

tgcacaaaga taactggagg attcagcact gatgcagtcg tggtgaacag gaggtctacc     3600

taacgcacag aaagtcatgc ttcagtgaca ttgtcaacag gagtccaatt atgggcagaa     3660

tctgctctct gtgaccaaaa gaggatgtgc actgcttcac gtgacagtgg tgaccttgca     3720

atatagaaaa acttgggagt tattgaacat cccctgggct tacaagaaac actgatgaat     3780

gtaaaatcag gggacatttg aagatggcag aactgtctcc cccttgtcac ctacctctga     3840

tagaatgtct ttaatggtat cataatcatt ttcacccata atacacagta gcttcttctt     3900

actgtttgta aatacattct cccttggtat gtcactttat atcccctggt tctattaaaa     3960

tatccatata tatttctata aaaaaagtgt ttgaccaaag taggtctgca gctatttcaa     4020

cttccttccg tttccagaaa gagctgtgga tattttactg gaaattaaga acttgctgct     4080

gttttaataa gatgtagtat attttctgac tacaggagat aaaatttcag tcaaaaaacc     4140

attttgacag caagtatctt ctgagaaatt ttgaaaagta aatagatctc agtgtatcta     4200

gtcacttaaa tacatacacg ggttcattta cttaaacctt tgactgcctg tatttttttc     4260

aggtagctag ccaaattaat gcataatttc agatgtagaa gtagggtttg cgtgtgtgtg     4320

tgtgatcata ctcaagagtc taaaaactag tttccttgtg ttggaaattt aaaaggaaaa     4380

aaatcgtatt tcactgtgtt ttcaatttat attttcacaa ctactttctc tctccagagc     4440

tttcatctga tatctcacaa tgtatgatat acgtacaaaa cacacagcaa gttttctatc     4500

atgtccaaca cattcaacac tggtatacct cctaccagca agcctttaaa atgcatttgt     4560

gtttgcttat ttgttttgtt caagggttca gtaagaccta caatgttttg tatttcttga     4620

cttattttat tagaaacatt aaagatcact tggtagttag ccacattgag aagtggttat     4680

cattgttaat gtggttaatg ccaaaaagtg gttaatatta ataagactgt ttccacacca     4740

taggcaataa tttcttaatt taaaaaatct aagtatattc ctattgtact aaatattttt     4800

cccaactgga aagcacttga ttgtacccgt aagtgtttga gtgatgacat gtgatgattt     4860

tcagaaagtt gttgtttttg tttccatagc ctgtttaagt aggttgtaag tttgaatagt     4920

tagacatgga aattatttta taagcacaca cctaaagata tctttttaga tgataaaatg     4980

tacacccccc catcaccaac ctcacaactt agaaaatcta agttgtttga tttctttggg     5040

atttcttttg ttgtgaaaca ctgcaaagcc aatttttctt tataaaaatt catagtaatc     5100

ctgccaaatg tgcctattgt taaagatttg catgtgaaga tcttagggaa ccactgtttg     5160

agttctacaa gctcatgaga gtttattttt attataagat gtttttaata taaaagaatt     5220

atgtaactga tcactatatt acatcatttc agtgggccag gaaaatagat gtcttgctgt     5280

tttcagtatt ttcttaagaa attgctttta aaacaaataa ttgttttaca aaaccaataa     5340

ttatcctttg aattttcata gactgacttt gcttttgacg tagaaatttt ttttctcaat     5400

aaattatcac tttgagaaat gaggcctgta caaggctgat aacctatatg tgatggagat     5460

cacccaatgc caagggcaga aagcaaacct agttaaatag gtgagaaaaa aaataataat     5520

cccagtgcca tttgtctgtg caaagagaat taggagagag gttaatgtta cttttttcca     5580

ttttggaaat aattttaatc aagtaactca aatgtgacaa aatttatttt tattttttgt     5640

ggttatattc ccaacaacat taaaaaatac tcgaggcata aatgtagttg tctcctactc     5700

tgcttctctt actatactca tacattttta atatggttta tcaatgattc atgtttccct     5760

caaatagtga tggtttacac ctgtcatgga aacaatccta gagagctcag agcaattaaa     5820

ccactattcc atgcttttaa gtagttttct ccaccttttt cttatgagtc tcactagatt     5880

gactgaggaa tgtatgtcta aattcctgga gaagatgata tggattggaa actgaaattc     5940

agagaaatgg agtgttcaat agataccacg aattgtgaac aaagggaaaa ttctatacaa     6000

ctcaatctaa gtcagtccac tttgacttcg tactgtcttt cacctttcca ttgttgcatc     6060

ttgaattttt taaaatgtct agaattcagg atgctagggg ctacttcttt aaaaaaaaaa     6120

aaaaaaaaga attcgtctga aaatgctcag gtttgtaaga atctaatctc acttacataa     6180

ctaagcactc cataataagt tttattaagt acaaagggag ccagaaaaaa tgacatttat     6240

ttcttctaga tcagaaaaat ttaaattaag ccctgccttg ctgtttagaa atatgtgggc     6300

attgttataa tttattcaat aaatttatgt tcctttgcct tcctgtggaa acagttttat     6360

cccactaaac taggaattag gggataaatc acaaacaaaa aaaaagttgc agcactgaaa     6420

aaaagtaatt tattgttttt gcaactggta tgtgaatttg tgtgataaaa ttatttattc     6480

ttatttaaca aaaatatgtt caaatttttc tatatttaaa atgttttgct gttgtcctac     6540

tttttaattt atgcttcatg tttgtgtata aagtacactt ttacactttg tgagtttaca     6600

taatatacag cactggttgc ttttgtattt ttttacagaa agctttctgt gtgaagcagg     6660

tgtatatgta tatattcctc atgtattctt attctgatac tatcattttt ctttccaagg     6720

aaattttaat ctgtcatgac caatagtgtt cattacttgt gcctatgata ataggttttt     6780

tacatcacat taacactatt ttttccaagt cacaaataag aaaaacactt attcaatgaa     6840

acaaggtgca agttttaaat ttgggtacac aaatagccta gaagcttcct acagacgcta     6900

agacacagcc aataatcaga tcctttcact tcatcgagaa acttggacaa gtcgatattg     6960

atgtattaga tgaaagttgt ctacacacaa cttctgaggg atacaaacga taataaaacc     7020

aaatgttgtc tgtttctcct ttagaaacac ctcctaaaat taatatcatt tagtctctag     7080

tgtctgtagg attctacaga tgagcacaaa tagattgggt ttgtataaca aatgctaata     7140

gtcataactg tttctacaaa tatggggtgt ccattaagag aatgtgatgt tttcctactg     7200

ctgttgaatc ccatggggtg attataggac ttgaaatagg cagagtcacc tctgatgaca     7260

tcagcttgcc tctgtgattt cacagtctga tcctggcaac aagacaaagc acccttggac     7320

acacagccaa tctctggttg tgatatttcc ccattgattc cttccttgtt aacaaggtca     7380

ttttaatggt tcaggtgagg acagcagcca gattcaaagt ccagaatttg tgctgttaca     7440

tagagttcac actgtcaaat aacattgaat ttaataatga tcaaattttt ctagtagtct     7500

ttggcagagt gtataatctc attggcatga ttggtgaata ttactaatct ctttataatg     7560

aaagatgctt tacaaatacc ttatatttgc taacatttca aaactactaa ataaatgaaa     7620

tagccatgtg tacagaaatg gtcatttaaa gctttaatag aaccaaattc aagacaatgt     7680

atcatttaga cacacagaaa aggaacttgt atgttttccc tattattttt ctcatttgcc     7740

aacaatctat agttttaggt tatcaaacag atagatcaac ttaactggct agtacattga     7800

aaaatcttcc taagaatcct ttgttagcat aatctataga gataatttct caaattatat     7860

catcatgatg catataaact ctataatgta taattgtgtt tcatttattt aatgtatgag     7920

aacatattga aatacaaaac catgcattag ccaaaaaatt ggaatacagg tagtgttcag     7980

atcagcaaaa cattcagtct ggtaaatgcc tgcctggggc tatgatatca ttctcaatgc     8040

aggttttatg gaaaaactaa aagaatatgt tgttagatga tgttggtttt gaaaaaaaaa     8100

agacattaac atacacatta gttagcccag ttaattgcat tctactaata tagttgcaca     8160

ttagcaataa ttttgctgtc tctggtcttt attttgtggc ttcaactaac tggaccatgt     8220

ggactgtaaa ggtcaaatgg aaaaaacgag cagtggcccc tcatcctgta aggtactgct     8280

acatcagagt gacctaaaag tctaacactg tgaggaaaac tgtgatttgt aggaaaaaaa     8340

aaaaaaacaa ataaaaaaca gggcatgctt tttaattttt ttccactttc ctttggcaca     8400

cccaatgaac aattctaatt tttattgagg tgctaacatc tttcgtgacc gactgtcaaa     8460

tgtggtattt ttgagttact atttttctac atgattttac agtttgcaag aaagacctct     8520

aagctttgtg tcacggtagg gcacaacttg atactcaaaa tttgaaaaat aagcacatcc     8580

aatgattgtt ttgaccaaca gtggtcagtg acgtaaactg catgtgcatc tgaggacatt     8640

taaggggtca ttaaaatttg aggagcatca ggccggagta gcagactttt agatgagtca     8700

tatttcagca ttcactaagt cctcagcatt ccattcaaac tgtcgtgtat atttggcctg     8760

attttttttc aagctttgca ataatttatg ttattggtaa acacttggtg actatatctc     8820

agccttttct ttaacaactc acaatatatt agaaacacgt ctacctatac tgagagtata     8880

tttacaatag aagaacatac tgtatgtgac tttgtaaagc tagacttttg attaagaaat     8940

atataatctc tggatgctat ttttgcatta tacactcagg cacaacgtaa accttgatgg     9000

ctcatcttgc tacaattacg agttgaaaaa cactacttac gtatttgtat gacctattag     9060

tcagaggaaa tcatacatat gctttgtaaa tagactttgc agataactaa atagactgaa     9120

gaaatatgtt gcatttgata gaagcaattg cataaatatt tggtttctat attagagtct     9180

gtgagtaaag tcaagtaata aacctaagta ggtataacag atttttaaac cttgaaactt     9240

gctttgatgg tagagaaaat cattgaagat ttacatactg tatataagat gtaaaatgta     9300

cgctgcttat taccctcaat tttccagaag caatggtata taatgcagtt gaaaaaccaa     9360

aaatcttgga aaactaagac gggtcttgtt taaaatgtct ctcagctttg gcaaccttca     9420

aatcttaatc aactatttaa agcattactg tgtcttgtag cctgcattcc acaacagctc     9480

tgttattcag gtaaaagact tgaactgagc cgtttgggac ctatactgta atattttcat     9540

tgaggaacaa tatcctattt tgtaaagcat ttccctatgt gtgactttaa actgtaaaat     9600

taaacactgc ttttgtgggt tcagtgggca taataaatat aaattgtaaa ctaggttaaa     9660

gta                                                                   9663


<210> 192
<211> 2787
<212> DNA
<213> Rattus norvegicus

<400> 192
atgctactcg agtgggcgtc cttgctgctg ctactgctgc tgctgtgcgc gtcctgcctg       60

gccctggcgg ctgacaaccc tgccgcggca cctgcccagg ataaaaccag gcagcctcgg      120

gctgctgcag cggccgccca gcccgaccag cggcagtggg aggaaacaca ggagcggggc      180

catccgcaac ccttggccag gcagcgcagg agcagcgggc tggtgcagaa tatagaccaa      240

ctctactctg gcggtggcaa agtgggctac cttgtctacg cgggcggccg gaggttcctg      300

ctggacctgg agagggatga cacagtgggt gctgctggtg gcatcgttac tgcaggagga      360

gggctgagcg catcctctgg ccacaggggt cactgcttct acagaggcac tgtggacggc      420

agccctcgat ccctagctgt ctttgacctc tgtgggggtc tcgatggctt cttcgcagtc      480

aagcatgcgc gctacactct gaagccgctc ttgcgtgggt cctgggcaga gtccgaacga      540

gtttacgggg atgggtcttc acgcatcctg catgtctaca cccgcgaggg cttcagcttc      600

gaggccctgc cgccacgcac cagttgcgag actccagcgt ccccgtctgg gccccaagag      660

agcccctcgg tgcacagtag ttctaggcga cgcacagaac tggcaccgca gctgctggac      720

cattcagctt tctcgccagc tgggaacgcg ggacctcaga cgtggtggag gcggaggcgc      780

cgttccatct ccagggcccg ccaggtggag ctcctcttgg tggctgactc ttccatggcc      840

aagatgtatg ggcggggcct gcagcattac ctgctgaccc tggcctctat tgccaaccgg      900

ctgtacagtc atgcaagcat cgagaaccac atccgcctgg ccgtagtgaa agtggtggtg      960

ctgaccgaca agagtctgga ggtgagcaag aacgcggcca cgaccctcaa gaacttttgc     1020

aaatggcagc accaacacaa ccagctaggt gatgaccatg aggagcacta cgatgcagcc     1080

atcctgttca ccagagagga tttatgtggg catcattcat gtgacaccct gggaatggca     1140

gacgttggga ccatatgttc tccggagcgc agctgcgctg tgattgaaga tgatggcctc     1200

catgcagctt tcactgtggc tcacgaaatt ggacatctac ttggcctctc tcacgacgat     1260

tccaaattct gtgaagagaa ttttggttct acagaagaca agcgtttaat gtcttcaatc     1320

cttaccagca ttgatgcatc caagccctgg tccaaatgca cttcagccac gatcacagaa     1380

tttctggatg acggtcatgg taactgttta ctagatgtac cacggaagca gattctgggc     1440

cccgaggaac tcccaggaca gacctatgat gccacccagc agtgcaactt gacatttggg     1500

cctgaatatt ctgtgtgccc tggcatggat gtctgtgcac ggctgtggtg tgctgtggtg     1560

cgccaaggcc aaatggtgtg tctgaccaag aagttgcctg ccgtggaggg cactccctgt     1620

ggtaaaggaa gaatctgcct gcaagggaaa tgtgtggaca aaactaagaa aaaatattac     1680

tcgacatcaa gccatggaaa ttgggggtcc tggggcccct ggggtcagtg ttctcgctct     1740

tgcgggggag gagtacagtt tgcctaccgc cattgcaata accccgcacc tcgaaacagt     1800

ggccgctact gcacagggaa gagggccata taccgttcct gcagtgtcat accctgccca     1860

cctaacggca aatctttccg ccacgagcag tgtgaagcca aaaatggcta tcagtccgat     1920

gcaaaaggag tcaaaacatt tgtagaatgg gttcccaaat acgcaggtgt cctgccggca     1980

gacgtgtgca agcttacgtg cagagctaag ggcactggct attacgtggt cttttctcca     2040

aaggttacag atgggacaga atgtagaccc tacagcaact ccgtgtgtgt ccgaggaagg     2100

tgcgtgagaa cggggtgtga cggcatcatc ggctcaaagc tacagtatga caagtgtgga     2160

gtgtgtggag gggataactc cagttgtaca aagattatcg gaaccttcaa taaaaaaagc     2220

aagggttata ctgacgttgt gaggatccct gaaggagcaa cccacataaa agtccgacag     2280

ttcaaagcca aagaccagac tagattcact gcttacttag ccctaaagaa gaaaactggc     2340

gagtacctta tcaacggcaa gtacatgatc tccacttcag agaccatcat cgacatcaat     2400

ggtaccgtca tgaactacag tgggtggagt cacagagatg attttttaca tgggatgggc     2460

tattcagcca caaaggaaat tctgattgtg cagatccttg caacagaccc aactaaagca     2520

ttagacgtcc gttacagctt ttttgttccc aagaagacca ctcaaaaagt gaattccgtc     2580

attagccaca gcagcaacaa agtgggacta cactccccgc agctacagtg ggtgacaggc     2640

ccctggctgg cctgctctag gacctgtgac acaggctggc acaccaggac cgtgcagtgc     2700

caggatggaa acaggaaatt agctaaggga tgcattctct ctcagaggcc ttctgcgttt     2760

aagcaatgtt tgctcaagaa atgttag                                         2787


<210> 193
<211> 8104
<212> DNA
<213> Mus musculus

<400> 193
gaaattgcca ttgcaggatg gcacgccgct ataaattcat tgtcccacct cctcgcatct       60

tcacagcgcc tgagccgctc tccgcgcccg tagcagccga ctggggatga tcccgggcgg      120

gaggacgcgg caacggaagg gaccgggacg cgccgcctcg ctggctctcc gcaggccgcc      180

tcctagcttt tgattttaaa catttttagg tgtttccttt gcttgctttc tttccttttc      240

ttttctcccg tctcatttct ccctgccttc gggttccagc ggagccgagg aagccctgag      300

aataagaaag gaagtgggtc ggagcttgga agctttgcag cccgccagcc ccgggcttcg      360

agggggcggg agcggacgcg caccagttgc gggccagcgc ggtcgccctt cttactctct      420

tagctcgttt gttttgatct gtttgtgcaa agatcttgtc tgcgttgggc ctctctcctt      480

ttttgtattt ggttgctctc cacctcttgg cttttactcc caccaacacc accctttatt      540

taattttttt tcttttattt tatttaaaat ttttcttcct ccgtctcttg gacctccatt      600

ccaaacattt tccaaaccaa caaagaaaaa gttctcacag tggcaccggt gccaggccag      660

gctggctctc tgctgcggat tccccctacc ctttcctgga cacttgactc aaccttgcac      720

gccagtgtgt agagtgtgcg gctgtgggtg ggtgggtggg agggcgagcc ccccaccccc      780

gcccctgaaa cttctatagc aaatagcaag catccagcta gactcagtcg cgcagcccct      840

cccggcgggc agcgcactat gcggctcgag tgggcgccct tgttgctgct actgctgctg      900

ctgagcgcgt cctgcctgtc cctggccgct gacagccccg ccgcggcacc tgcccaggat      960

aaaaccaggc agcctcaggc tgcagcagcg gccgccgagc cggaccagcc gcagggggag     1020

gaaacacggg agcgaggcca tttacaaccc ttggccgggc agcgcaggag cggcgggctg     1080

gtccagaata tagaccaact ctactctggc ggtggcaaag tgggctacct tgtctacgcg     1140

ggcggccgga ggttcctgct ggacctggag agagatgaca cagtgggtgc tgctggtagc     1200

atcgttactg caggaggagg gctgagcgca tcctctggcc accggggtca ctgtttctac     1260

agaggcaccg tggacggcag ccctcgatcc ctagctgtct ttgacctctg cgggggtctc     1320

gatggcttct ttgcagtcaa gcatgcgcgc tacactctaa agccactcct gcgtgggtcc     1380

tgggcagagt atgaacgaat ttatggggat ggatcttccc gcatcctgca tgtctacaac     1440

cgcgagggct ttagcttcga ggccctgccg ccacgcgcca gttgcgagac tcctgcatcc     1500

ccatctgggc cccaagagag cccctcggtg cacagtagat ctaggagacg ctcagcgctg     1560

gccccgcagc tgctggacca ctcagctttc tcgccatctg ggaacgcggg acctcagact     1620

tggtggaggc gtaggcgccg ttccatctcc agggcccgcc aggtggagct cctcttggtg     1680

gctgactcgt ccatggccag gatgtatggg cggggcctgc agcattacct gctgaccctg     1740

gcctccatcg ccaacaggct gtacagtcat gcaagcattg agaaccacat ccgcctggcg     1800

gtggtgaagg tggtggtgct gacggacaag gacacgagtc tggaggtgag caagaatgcg     1860

gccacgaccc tcaagaactt ttgcaaatgg cagcaccaac ataaccagct aggggatgat     1920

cacgaagagc actacgatgc agccatcctg ttcacccgag aggatttatg tgggcatcat     1980

tcatgtgaca ccctgggaat ggcagacgtt gggaccatat gttctccgga gcgcagctgt     2040

gcagtgattg aagatgatgg cctccatgca gccttcactg tggctcatga aattgggcat     2100

ctacttggcc tttctcatga cgattccaaa ttctgtgaag agaacttcgg tactacagaa     2160

gacaagcgtt taatgtcttc aatccttacc agcatcgatg catccaagcc ctggtccaaa     2220

tgcacgtcag ccaccatcac agaattcctg gatgatggtc atggtaattg tttgctagac     2280

ctaccacgga agcagatttt gggtcccgag gaactcccag gacagaccta cgatgccacc     2340

cagcagtgca acttgacatt tgggcctgag tactcggtgt gccctggcat ggatgtctgt     2400

gcgcggctgt ggtgtgctgt ggtgcgccaa ggccaaatgg tgtgtctgac caagaagctg     2460

ccggctgtgg agggcactcc ctgtgggaag ggaagagtct gccttcaagg caaatgtgtg     2520

gacaaaacta agaaaaaata ttactcgaca tcaagccatg gaaattgggg gtcctggggc     2580

ccctggggtc agtgttctcg ctcatgcggg ggaggagtgc agtttgccta ccgccattgt     2640

aataaccctg cacctcgaaa cagtggccgc tactgcacag ggaagagggc catataccgt     2700

tcctgcagtg ttacaccctg cccacccaat ggtaaatctt ttcgccatga gcagtgtgaa     2760

gccaaaaatg gctatcagtc tgatgcaaaa ggagtcaaaa catttgtaga atgggttccc     2820

aaatatgcag gtgtcctgcc ggcagatgtg tgcaagctta cctgcagagc taagggcaca     2880

ggctactatg tggtcttttc tccaaaggtt acggatggga ctgaatgcag gccgtacagc     2940

aactctgtgt gtgtccgagg acggtgtgtg agaactggat gtgacggcat tattggctca     3000

aagctacaat atgacaagtg tggagtgtgc ggaggggata actccagttg tacaaagatt     3060

atcggaacct tcaataaaaa aagcaagggt tatactgacg ttgtgaggat ccctgaagga     3120

gcaacccaca taaaagtccg acagttcaaa gccaaagacc agactagatt cactgcctac     3180

ttagccctga agaagaaaac tggcgagtac cttatcaatg gcaagtacat gatttccact     3240

tcagagacca tcatcgacat caatggtacc gtcatgaact acagtggatg gagccacaga     3300

gatgattttt tacatgggat gggctattca gccacaaaag aaatcctgat cgtgcagatc     3360

cttgccacag acccaactaa agcgctagac gtccgttaca gcttttttgt tcccaagaag     3420

accactcaaa aagtaaactc tgtcatcagc catggcagca acaaggtggg accacactct     3480

acacagctgc agtgggtgac aggtccatgg ctggcctgct ccaggacctg tgacacaggc     3540

tggcacacta ggaccgtgca gtgccaggat ggaaacagga aattagctaa aggatgcctt     3600

ctctctcaga ggccttctgc atttaagcaa tgtctgctga agaaatgtta gcctgtggtt     3660

tactctaatg cacaaaaaaa caacaggagg atcatcgcag atacagctgt ggtgaagaca     3720

aggcctaccc aaagcacaga aagtcatgcc ttcatgtcat tgtcaccacg agtcgaatta     3780

tgggcagaat ctgctctctg cgaccaaaag gtttactcta cttggtgtaa tgatggtgac     3840

cttggaataa agaaaacgtg agggtcatgg aacatccctg ggcctacaca aaggagacac     3900

acaatgatga atgtagaatc ggggacattt gaagatggca gagaagtctt gtcacctacc     3960

tcttatagaa tgtcttcaaa gacatcgtga tcatgttcag ccatgacaca cagcttattt     4020

ttactgtttg taaatgcatc cgcccttagt atgtcacttt ataaacttgg tcctattaat     4080

atatacacat gtgtaaatac aatatatata tttgaccaaa gtaggtctgc agctatttca     4140

actactattt tccagaaaga gctgaagaag atttactgga aattaagaac ttgctgctgt     4200

taaataaaac tttgtatatt gtcagcctgc aggagataac attttagtca aaaaaaaaaa     4260

aaaaagaaaa aaaagaaaaa gaaaagaaaa agaaagaaac cattttgaca gcaagcacct     4320

tctgtgaagt tctaaaaagg gaaaggatct gcgtgtgtct ggtcatttaa acacatattc     4380

agttctgtgt actctagagt ttgacggtct gtatattttt caggcagcca agccaagtta     4440

ttgtatcatt tgggtgtaga aactgtgttt tcctgtgtat atgtgatcaa tatccaaggg     4500

tctaaaagtt agcttgcttg tattggaatt taaaacaaca acaacaaaaa gaaatatgtc     4560

actgtgtttt caatttgtat tttcacaact gcttcctttt ctatggctcc tggttcatat     4620

ctcacagtgt gtagggatca tagagaacac gcagagccgc aagctgtctg tcacatccag     4680

cttccgcagt aatggctcac ctctgctcag ccagggttta aaatgtgttt gtggttgctt     4740

gtttgttttt cctgagggtg ggaagatgta tgttctgtat tggctgggtc taacagtaat     4800

attaaaatca tttcgtattt agcctcatct tgaacgagca atcggatcag ttcaactaat     4860

tcaagaaacc aaactagtta gcacttaaaa gactgtttcc acaccatagg caattatctc     4920

ataatttaca aaatataagc atatgtctgc tgtattagag aatttctgct ctcagaaggc     4980

gtttgtctct accagtgagt atgtaagtga tggaatataa gtggtttcag gaagtctttt     5040

acctgcacaa gaaggtcgca cacgcttaat gataatcata atctccttta actactcact     5100

gaaaggcccc cctccgataa ttcaaataat atgacgtggt tttattccac tggcatttct     5160

tttttcttcg taaaaatctg caaagtaaat tgttttacac aaattctata gtgaccatac     5220

caaatgtgcc tactgtgaaa gatttgcata gaaggatttt gagaaatcct ctctggaatt     5280

ccactaaatg tatgagagtt tatttttatt ataggatatt ttaatataaa taactatgta     5340

attgatgact ccatatcaca ttgatttcag tgggacagaa aaagaatgca atcctactta     5400

ggtttgtttg tttgtttgtt tgttttaaga gattattttg tgaaacagac caatgccctc     5460

ccaaaccagt catcatccat tggcttctca cagcctggtc tttttacatc aagaaatgca     5520

gactatacag aacttgtagc ctatattggg tgcaggtctc caaatataga gcagggagtt     5580

catttagtca aattggtcat aagacaaaaa attaaatctc acgttgctta tttaactgta     5640

cagagagaat aaatagtata atgcaacttt ctccaatttc taaaaacaat ataagccaag     5700

tagttccaat ttgacaaaat tcttattttg ttttttgttg tggttatatt aaaaaaaata     5760

aatgaagagt aaatgtgatt atctcctact ctgcttccct ctatgatcat catagttttt     5820

tttaataata ttttcactgg gttactttcc ctataataat cgagttttat acttcacact     5880

gaaatcatcc taaggagggt aaacggataa accactaatc tatgtctaga gggattttct     5940

ttatgtttta aaaagactat tcctacattg acaggggaat gtatataaat ctcctgagga     6000

aagaaacaca gcaaactgag agtcagaaat ctgaagtgtc acagagggaa agagaaattg     6060

agtgtgggag gagaaaccga tattaaattc caattcattc agttagattc tgtgctgtgt     6120

ttgccatctt cccggttgtg tatcttgaat cgttaaagac cttggattta agatggtgaa     6180

taaaggtggg gaaacagaac aaggcagtgc tctggttaca aaatgtctaa ccttgcttgc     6240

ataaaaaaat tattccagag tgagtgtcag tgcaaaagag cccagagtga aacagtacct     6300

tgatctatca gaacagcaaa tgccacctta aaaccccctt attgcttgaa agtataagga     6360

catggttata gtgtatttaa cagactcaac atctattgcc ttcctgtgga aacagtttta     6420

aactaacagt tgagggatga atcacaaaca aacagaataa gaagttgcag cactgaaaac     6480

taagtaattt attgtttttg caactgccat gtgaatttct gtgatgaaat tatttattct     6540

tatttaacaa aaattatgtg caaaatctta tatttgaaat gttttgctgt tgtccttttt     6600

ttaatttatg cttcttgttt gtgtataaag tgcactttgt gagtttatat aatatacagc     6660

actggtggct ttgtatttct tttttacaga aggctttctg tgtggaacag gtgtatgtgt     6720

gtatattccg catgtatttt cagtctgcca ctctcttaaa ttttaaagga acattgatca     6780

ctatgttaat aggtcattta aataccaata acattggctt tttcagatca tgagttttaa     6840

aaatgtgtat tcaatccagc aagttgcaac tggtttttaa ctagaggaca tatatacctt     6900

aggaacatct caacagaagc taagacacaa tggagaacag ggtttgaaac aggcatagca     6960

cacaggaggc tgaaggagga agattatgaa cttaagagtt gtctgggagc catagcaggc     7020

ccctagtttg gtggaagaaa tagaatcagt ttcagtcaca tcactgataa ttatatacaa     7080

ggagacttaa atttattata tgcatgttat agacacataa cttctaagtg attaaagaat     7140

gataaataca aactcttaca gctttagaaa cagcttccca caaaaacagt gtctgagcct     7200

ctgctgtctg tagagattct agagatgatc tcaaatgaaa gtggatttgt gtatttctaa     7260

taccagtcat aaccttgtct atgggtgtaa gtgcacataa caaagtaaga ctttttacta     7320

ctactatcag accagagtgg taggacatgg gacaagcagg aacaactctg gtaacaacag     7380

ctcatttgtg agtgagactg tgcggtccag gtctagaaat aaagtcaagc actcttggcc     7440

ccactgtata agtcattggg tcaagccctg gctccgatgt tcctccatta ataacttcct     7500

tgttagcaaa ttaacaaggt cagtcagtgc aaccagcagg gaacataggc aggttcagaa     7560

atccagggtg tgcactatga ctgcagctca ttgttagaaa tatgatgaat acaatgctta     7620

attctactct gagttgagaa ccctgcaaaa cagccatact gtgctaatac cactcatcta     7680

tttacactga aacatgggac cgtacaaatg cattacattt tttattattt catggctaca     7740

aaataaaaga aataaccaca agagcaaaat aggtcaaagc agatgcaaaa tcatattaag     7800

gaagttttat cattaaaaca cagagaaaag gcacttgtat ggtttctgta ttattatttt     7860

ctttggccaa cagtctacag ttgcaaagaa tcaaacaaat agatcagcct aaccgaatag     7920

tttggtaaaa atgtggtaat aaacccttat taatgtgaaa tataggcatg gcttattgaa     7980

tcatatcacc acaaaacata gcaatctata atcaacccat taattctatt caatcaaaca     8040

atgaggacac attgcaatac aggtccattc attattaagc taatgcacag gaataaaaat     8100

cagt                                                                  8104


<210> 194
<211> 3572
<212> DNA
<213> Homo sapiens

<400> 194
acctgcactt ctgggggcgt cgagcctggc ggtagaatct tcccagtagg cggcgcggga       60

gggaaaagag gattgagggg ctaggccggg cggatcccgt cctcccccga tgtgagcagt      120

tttccgaaac cccgtcaggc gaaggctgcc cagagaggtg gagtcggtag cggggccggg      180

aacatgaggc agtctctcct attcctgacc agcgtggttc ctttcgtgct ggcgccgcga      240

cctccggatg acccgggctt cggcccccac cagagactcg agaagcttga ttctttgctc      300

tcagactacg atattctctc tttatctaat atccagcagc attcggtaag aaaaagagat      360

ctacagactt caacacatgt agaaacacta ctaacttttt cagctttgaa aaggcatttt      420

aaattatacc tgacatcaag tactgaacgt ttttcacaaa atttcaaggt cgtggtggtg      480

gatggtaaaa acgaaagcga gtacactgta aaatggcagg acttcttcac tggacacgtg      540

gttggtgagc ctgactctag ggttctagcc cacataagag atgatgatgt tataatcaga      600

atcaacacag atggggccga atataacata gagccacttt ggagatttgt taatgatacc      660

aaagacaaaa gaatgttagt ttataaatct gaagatatca agaatgtttc acgtttgcag      720

tctccaaaag tgtgtggtta tttaaaagtg gataatgaag agttgctccc aaaagggtta      780

gtagacagag aaccacctga agagcttgtt catcgagtga aaagaagagc tgacccagat      840

cccatgaaga acacgtgtaa attattggtg gtagcagatc atcgcttcta cagatacatg      900

ggcagagggg aagagagtac aactacaaat tacttaatag agctaattga cagagttgat      960

gacatctatc ggaacacttc atgggataat gcaggtttta aaggctatgg aatacagata     1020

gagcagattc gcattctcaa gtctccacaa gaggtaaaac ctggtgaaaa gcactacaac     1080

atggcaaaaa gttacccaaa tgaagaaaag gatgcttggg atgtgaagat gttgctagag     1140

caatttagct ttgatatagc tgaggaagca tctaaagttt gcttggcaca ccttttcaca     1200

taccaagatt ttgatatggg aactcttgga ttagcttatg ttggctctcc cagagcaaac     1260

agccatggag gtgtttgtcc aaaggcttat tatagcccag ttgggaagaa aaatatctat     1320

ttgaatagtg gtttgacgag cacaaagaat tatggtaaaa ccatccttac aaaggaagct     1380

gacctggtta caactcatga attgggacat aattttggag cagaacatga tccggatggt     1440

ctagcagaat gtgccccgaa tgaggaccag ggagggaaat atgtcatgta tcccatagct     1500

gtgagtggcg atcacgagaa caataagatg ttttcaaact gcagtaaaca atcaatctat     1560

aagaccattg aaagtaaggc ccaggagtgt tttcaagaac gcagcaataa agtttgtggg     1620

aactcgaggg tggatgaagg agaagagtgt gatcctggca tcatgtatct gaacaacgac     1680

acctgctgca acagcgactg cacgttgaag gaaggtgtcc agtgcagtga caggaacagt     1740

ccttgctgta aaaactgtca gtttgagact gcccagaaga agtgccagga ggcgattaat     1800

gctacttgca aaggcgtgtc ctactgcaca ggtaatagca gtgagtgccc gcctccagga     1860

aatgctgaag atgacactgt ttgcttggat cttggcaagt gtaaggatgg gaaatgcatc     1920

cctttctgcg agagggaaca gcagctggag tcctgtgcat gtaatgaaac tgacaactcc     1980

tgcaaggtgt gctgcaggga cctttctggc cgctgtgtgc cctatgtcga tgctgaacaa     2040

aagaacttat ttttgaggaa aggaaagccc tgtacagtag gattttgtga catgaatggc     2100

aaatgtgaga aacgagtaca ggatgtaatt gaacgatttt gggatttcat tgaccagctg     2160

agcatcaata cttttggaaa gtttttagca gacaacatcg ttgggtctgt cctggttttc     2220

tccttgatat tttggattcc tttcagcatt cttgtccatt gtgtggataa gaaattggat     2280

aaacagtatg aatctctgtc tctgtttcac cccagtaacg tcgaaatgct gagcagcatg     2340

gattctgcat cggttcgcat tatcaaaccc tttcctgcgc cccagactcc aggccgcctg     2400

cagcctgccc ctgtgatccc ttcggcgcca gcagctccaa aactggacca ccagagaatg     2460

gacaccatcc aggaagaccc cagcacagac tcacatatgg acgaggatgg gtttgagaag     2520

gaccccttcc caaatagcag cacagctgcc aagtcatttg aggatctcac ggaccatccg     2580

gtcaccagaa gtgaaaaggc tgcctccttt aaactgcagc gtcagaatcg tgttgacagc     2640

aaagaaacag agtgctaatt tagttctcag ctcttctgac ttaagtgtgc aaaatatttt     2700

tatagatttg acctacaaat caatcacagc ttgtattttg tgaagactgg gaagtgactt     2760

agcagatgct ggtcatgtgt ttgaacttcc tgcaggtaaa cagttcttgt gtggtttggc     2820

ccttctcctt ttgaaaaggt aaggtgaagg tgaatctagc ttattttgag gctttcaggt     2880

tttagttttt aaaatatctt ttgacctgtg gtgcaaaagc agaaaataca gctggattgg     2940

gttatgaata tttacgtttt tgtaaattaa tcttttatat tgataacagc actgactagg     3000

gaaatgatca gttttttttt atacactgta atgaaccgct gaatatgagg catttggcat     3060

ttatttgtga tgacaactgg aatagttttt tttttttttt tttttttttg ccttcaacta     3120

aaaacaaagg agataaatct agtatacatt gtctctaaat tgtgggtcta tttctagtta     3180

ttacccagag tttttatgta gcagggaaaa tatatatcta aatttagaaa tcatttgggt     3240

taatatggct cttcataatt ctaagactaa tgctctctag aaacctaacc acctacctta     3300

cagtgagggc tatacatggt agccagttga atttatggaa tctaccaact gtttagggcc     3360

ctgatttgct gggcagtttt tctgtatttt ataagtatct tcatgtatcc ctgttactga     3420

tagggataca tgctcttaga aaattcacta ttggctggga gtggtggctc atgcctgtaa     3480

tcccagcact tggagaggct gaggttgcgc cactacactc cagcctgggt gacagagtga     3540

gactctgcct caaaaaaaaa aaaaaaaaaa aa                                   3572


<210> 195
<211> 4126
<212> DNA
<213> Rattus norvegicus

<400> 195
ttccggctgt gggcagcagg gtggtccgcg actgcggccg gaagcaggct gagcggctct       60

cggcgagcgc cgcctgtact tccggggact tcagcctagc tcttgagttt tccctgtagg      120

cggcgcggga gggaaaagtt tgcagggccg tgctgggaag atcacctccg cttcccaatg      180

tgagcagttt ctcgaacgct ctctctagaa ggttgcccag agaggtggtg gacgggaaca      240

tgaggcagcg tctcctcttc ctgaccactt tggtgccttt cgtcctggca ccccgacctc      300

cggaggaacc aggctctggc tcccacctgc gacttgagaa gcttgattct ttgctctcag      360

actacgatat cctctcttta tctaatatcc agcagcactc cataaggaaa agggatctac      420

agtctgcgac acacttagaa acactactaa ctttttcagc tttgaaaagg cattttaaat      480

tatacttgac atcaagtaca gaacgctttt cacagaactt gcgagtcgtg gtggtggatg      540

ggaaagagga aagcgagtac agtgtgaagt ggcaggactt cttcagcgga catgtggttg      600

gtgagcctga ctctagggtt ctagcgcaca taggagatga tgatgtcaca gtaagaatca      660

acacagatgg ggcagaatat aacatagagc cactttggag gtttgttaat gatactaaag      720

ataaaaggat gctggtgtat aagtctgaag atatcaagga tttttcacgt ttgcagtctc      780

caaaagtatg tggttattta aatgcagata gtgaagagtt gcttccaaaa gggctcatag      840

acagagagcc atctgaagag tttgtccgtc gagtgaagag gcgagctgaa cctaacccat      900

tgaagaatac ttgtaaatta ctggtggtgg cagatcatcg attttataag tacatgggcc      960

gaggagaaga gagcactact acaaattact taatagagtt aattgaccga gttgatgaca     1020

tataccggaa cacctcgtgg gacaatgcag gatttaaagg ttatggagta cagatagaac     1080

agattcgaat tctcaagtct ccacaagagg taaaacctgg tgaaagacac ttcaatatgg     1140

caaaaagttt tccaaatgaa gaaaaggatg cttgggatgt gaagatgctg ctggagcaat     1200

ttagccttga tatagctgaa gaggcctcta aagtctgcct ggctcatctt ttcacctacc     1260

aagattttga tatgggaact cttggattag cttacgttgg ttctcccaga gcaaacagtc     1320

atggaggggt ttgtccaaaa gcttattaca acccaggtgt gaagaagaac atctatttga     1380

atagtggtct gacaagtaca aaaaattatg gtaaaaccat ccttacaaag gaggctgacc     1440

tggttacaac tcatgaattg ggacacaatt ttggagcaga acatgatcct gatgggctgg     1500

cagagtgtgc cccaaatgag gaccaaggag gaaagtatgt tatgtacccc atagctgtga     1560

gtggtgacca tgagaataat aagatgtttt caaactgcag taaacagtcc atctacaaga     1620

ccatagaaag caaggctcaa gagtgcttcc aggagcgcag caacaaggtg tgcggcaact     1680

ccagggtgga cgaaggagaa gagtgtgacc cgggcatcat gtacctgaac aacgacacct     1740

gctgcaatag tgactgcaca ctgaagccag gtgtgcagtg cagtgatagg aatagtcctt     1800

gctgtaaaaa ttgtcagttt gagacggccc agaagaagtg ccaggaggct atcaatgcta     1860

cttgcaaagg agtgtcttac tgcacaggga atagcagtga gtgcccccca ccaggagatg     1920

ctgaagatga cactgtgtgc ttggacctgg gcaagtgcaa ggctgggaaa tgcatccctt     1980

tctgcaagag ggagcaggag ctggagtcct gcgcatgtgc tgacaccgac aactcgtgca     2040

aggtatgctg caggaacctt tctggcccat gtgtgcctta cgtcgatgca gagcaaaaga     2100

acttattttt gaggaaaggg aagccctgta cagtagggtt ttgtgacatg aatggcaaat     2160

gtgagaaacg ggtacaggac gtaattgagc ggttttggga tttcattgac cagctgagca     2220

tcaacacttt tgggaagttt ctggcagaca acatcgttgg gtctgttctg gttttctcct     2280

tgatattttg gattcctttc agcattcttg tccactgtgt ggataagaaa ctggacaagc     2340

agtatgagtc cctgtctctg tttcatcaca gtaacattga gatgttgagc agcatggact     2400

cagcatctgt tcgcattatc aagccgttcc ctgcacccca gactccaggt cgtctgcagg     2460

ccctgcagcc ggctgcaatg atgccgccag tgtctgcggc tccaaaactg gatcaccaga     2520

ggatggacac catccaggaa gaccccagca cagattcaca tgtggatgat gatggctttg     2580

agaaggaccc cttccccaac agcagtgcag ccgccaagtc ctttgaggac ctcacagacc     2640

acccagtcac caggagtgag aaggccgcct ccttcaagct gcagcgtcag agccgagttg     2700

atagcaaaga gacagagtgt tagtgggagc ctgggcctgc tctgggggac acagacctac     2760

agatgttcca cagagctgac ctgaatcaaa atagactgta atgatctgag aaacgggagc     2820

agcttagcag atgctggtca tgtgacagga ccttcacatg acatcctgtg tatgtaggcc     2880

ctttgaagag gtgaggtaaa tctggcttat ttaaggcttt caggttttgg ggttttcttt     2940

tgtaatctaa aaatctcctt tgacctgtgg tgcagaagca gaaaataagg ctggatcaag     3000

ttcctggtga cagcactgat taagccttca gtctgttttt ctgtatgctg taaggtcctc     3060

tcactacggt gaagcactta gcagtgagga taactggaac acagactttt tgggggtttt     3120

ggccttcaca tgtgcgttgt ctccaaatgc cgtctgtctt ggcactgaac tttgtggata     3180

cagtcctttc caagatgaag actagctctg gaacagtcta tacaaacagc cacatgaact     3240

tcaagatggc ctattaactg cttagcccca ggttccctgg acagtttttc cgttttgcaa     3300

aaagtgtctt cacgggtctc taaacattgt ttgtcttaaa aaatactggg ctggagagtt     3360

ggccccacag ttaagagcac ttggtttcat tcccagtacc cacacggtgg ctcttaactc     3420

caatcccagg ggagatgaca tcttctgaac tctagaacac aaggcatgca ttggtgcagt     3480

caaacatgca ggcaacacac acaaatttag aaagccaagt gctgtaagaa gttgcacatc     3540

ccccaaccta cagtgcttcg cggtctgagc tggagtggag ctctctcctg aacactctgg     3600

aaggctggca ggtgctgagc tggctaggga gacgggtggg gcccagccct ggaagaaccg     3660

tcttcagcct cagcaagcag acactcgcgt tacctcaggc tttggggctt caggacccag     3720

gatgttttgt acttattgtg tgaggataaa taccattagc ctgaattctc atttctgtaa     3780

gttttagtta taaaagcttt ttttcttcta agaattgcaa tgtgctcacc agcaaacacg     3840

tcttaaccag aataacttgt aactctgagg acagttaacc aaacctgtgc cttgtctctc     3900

ctgagggtgt ctgttacact aatacttgaa catgtacctt gtggtattgg ctccttttac     3960

tagtcatgac agccttatat gttagttaca ctttgaggat ttgctctaag gtgagtgggg     4020

tgtgtgggtg tatgtatgaa tgaaacagtt ggcagaatat aagaaaacca tttttataaa     4080

attgtgactt tttaaaacaa aaaaaaaaaa aaaaaaaaaa aaaaaa                    4126


<210> 196
<211> 4508
<212> DNA
<213> Mus musculus

<400> 196
gctgcggccg gaaacgagtt aagccgctct cagcgagcgc cgcctgcact tccggggacg       60

tgagcctagc ttccctgtag gcggcgcggg agggagaagt ttgcagggcc gtgctgggaa      120

gatcacctcc gctcccaatg tgagcagttt cccgaacgct ctttcggaga aggtttccca      180

gagaggtggt ggacgggaac atgaggcggc gtctcctcat cctgaccact ttggtgcctt      240

tcgtcctggc accccgacct ccggaggaag caggctctgg ctcccatccg cgacttgaga      300

agcttgattc tttgctctca gactacgaca tcctctcctt agctaatatt cagcagcact      360

ccataaggaa aagggatcta cagtctgcga cacacttaga aacattacta actttttcag      420

ctttgaaaag acattttaaa ttatacttga catcaagtac cgaacgcttt tcacaaaact      480

tgagagtcgt ggtggtggac gggaaagaag aaagcgagta cagcgtgaag tggcagaact      540

tcttcagtgg tcacgtggtt ggtgagcctg actctagggt tctagcccac ataggagatg      600

atgatgttac agtgagaatc aacacagatg gggcagaata taacgtagag ccactttgga      660

ggtttgtcaa tgatactaaa gataaacgaa tgctggtgta taagtctgaa gatatcaagg      720

atttttcacg tttgcagtct ccaaaagtat gtggttattt aaatgcagat agtgaagagc      780

tgcttccaaa agggctcata gacagagagc catctgaaga gtttgttcgt cgagtgaaga      840

gacgagctga acctaacccc ttgaagaata cttgtaaatt actggtggta gcagatcatc      900

gattttataa atacatgggc cgtggagaag agagcaccac tacaaattac ttaggctaca      960

tttcaggcac tcgggacaga gtgacgaccg actgcttttt agagtttttg atagagctaa     1020

ttgaccgagt tgatgacata taccggaaca cgtcgtggga taatgcaggg tttaaagggt     1080

atggagtgca gatagagcag attcgaattc tcaagtctcc acaagaggta aaacctggtg     1140

aaagacactt caatatggca aaaagtttcc caaacgaaga gaaggatgct tgggatgtga     1200

agatgctatt agagcaattt agctttgata tagctgaaga agcatctaaa gtctgcctgg     1260

ctcatctttt cacgtaccag gattttgata tgggaactct tggattagct tacgttggtt     1320

ctcccagagc aaacagtcat ggaggggttt gtccaaaagc ttattacaac ccaactgtga     1380

agaaaaacat ctatttaaat agtggtctga ctagtactaa aaattatggc aaaactattc     1440

tcacaaagga agctgacctg gttacaactc atgaattggg acataatttt ggagcagaac     1500

atgaccctga tgggctagca gaatgtgccc caaatgagga ccaaggagga aagtatgtca     1560

tgtatcccat agctgtgagc ggtgaccacg agaataataa gatgttttca aactgcagta     1620

aacagtccat ctacaagacc atagaaagta aggctcaaga gtgcttccag gagcgcagca     1680

acaaggtgtg tggcaactcc agggtggatg aaggagagga gtgtgacccg ggtattatgt     1740

acctgaacaa cgacacctgc tgcaatagtg actgcacact gaagccgggt gtgcagtgca     1800

gtgataggaa cagtccttgc tgtaaaaact gtcagtttga gacggcgcag aagaagtgcc     1860

aggaggctat taatgctaca tgcaaaggag tgtcttactg cacagggaat agcagtgagt     1920

gccccccacc cggagatgct gaagatgaca ctgtgtgctt ggaccttggc aagtgcaagg     1980

ctgggaaatg catccctttc tgcaagaggg agcaggagct ggagtcctgc gcatgcgttg     2040

acactgacaa ctcgtgcaag gtgtgctgca ggaacctttc tggcccgtgt gtgccgtacg     2100

tcgatgcaga gcaaaagaac ttgtttttga ggaaagggaa gccatgtaca gtagggtttt     2160

gcgacatgaa tggcaaatgt gagaaacgag tacaggacgt aattgagcga ttttgggatt     2220

tcattgacca gctgagcatc aacacttttg ggaagtttct ggcagataac atcgttgggt     2280

ctgttctggt tttctccttg atattttgga ttcctttcag cattcttgtc cactgtgtgg     2340

ataagaaact ggacaagcag tatgaatccc tgtctctgtt tcatcacagt aacattgaga     2400

tgctgagcag catggactca gcatctgttc gcatcatcaa gccctttcct gcaccccaga     2460

ctccaggtcg tctgcaggcc ctgcagccag ctgccatgat gccgccagta cctgcagctc     2520

caaaactgga ccaccagagg atggacacca tccaggaaga ccccagcaca gactcacatg     2580

cagatgatga cggttttgag aaggacccct tccccaacag cagcacagct gccaagtcct     2640

ttgaggatct cacagaccac ccagtcacca ggagcgaaaa ggcggcctca ttcaagctgc     2700

agcgtcagag ccgagttgac agcaaagaga cagagtgcta gtggggaacc ttggcctgct     2760

ctaggacata tacctgcaga tgttccatag agctgacctg aatcaaaaca tagattataa     2820

tgatctgaga aacggggaag caacttagca gatgctggtc atgtgctatg accttcacat     2880

gacatcctat gtatgtaggc cctttgaaga ggtgaggtaa atctggctta tgtaaggctt     2940

tcaggttttg ggtttttctt ttataatcta aaatctcctt tgacctgtgg tgcagaagca     3000

gaaagtaagg ctggaccccg ttcctggtga cagtgctgtt aagtcttcag tctgtttttc     3060

tgtaccctct gactacagtg aagcacttaa cagtgaggat aactggaaca cagacatact     3120

tgtttgtttg ttttgttttt gtttttgttt tttttttttt gaccctcaac taaaagagga     3180

gcaagagaaa cctgcttgta tgttgtctcc aaatgcggcc tgtcttggca ctgaattctt     3240

tgtagatgga gagacctgcc tacacttagg gccatctaca ttaagagcag tcctttccaa     3300

gaggaacagt ttatagaaac agccacatga acttcgagat ggcctattaa ctgttcagcc     3360

ccagattcac tgggcagttt ttccatttta caaatgtgtc gtctttaaac tgtttgcctt     3420

aaaaaaaaaa atcaatattg ggctggagag ttggccccac agttaagagc agttggtctc     3480

attctcagca cccacatggt ggctctcaac tctgtaactc caatcccaga ggagatgaca     3540

tcttctgaac tctaggacac gaggcataca ttggtgcagg caaaacaaag ccaagtgctg     3600

taaaatgtgg caataaccac aaaacctata gtgcctcaca gtatggactg agtggtgaat     3660

agacactctt cccagaacca cttctggaca ggccgggatg tgctggctgg ctaggaagag     3720

ggggtgggag tgggagagtg gtgctgccat cggggcccag ccctagaaga actgaccttc     3780

agtctcggca agtagacacc cacgtgacct ctggctctgg tgcttcaaga tgttctgtac     3840

ttactgtgtg aggaataaat gccattagcc tgaattctga tttctataaa ttctagttat     3900

aaatgctctt ttcttctaag aattgcagtg tgctcacaag ccaacacatt ttaaccaaga     3960

taatttgtaa actctgagga cagttaacca agcctgtgcc ttgtctctcc tgaggacgcc     4020

tgttacacta atacttgaat atataccttg tggtatttgc tctttttact agtcatgata     4080

gtcttgtatt ttaattacac tttgatgatt tgctataggg agagtggggt gtgtgggtat     4140

atgtatgaat gaaacagttg gcagaatata agaaaaccat ttttataaaa ttgtgacttt     4200

ttaaaccaaa attgtcttaa ttgtattact ttttttttct ttggcatgta cagaattaat     4260

aagatgctca gggcatattc tatagctgtg gcattgatga tacctgcctc agtcaataaa     4320

tactgaatat caaagcagtg gattgcgtat ataacatttc cctgaaaaat aagttagtag     4380

gttttttgat caataatcat gaacagaagt taagcttgga aaagacattt aatcaatctc     4440

ttgatgtctg tgaattacta ataaagctac gcacatgttc acagaatgtt tgtggctacc     4500

aacatgaa                                                              4508


<210> 197
<211> 4470
<212> DNA
<213> Mus musculus

<400> 197
gctgcggccg gaaacgagtt aagccgctct cagcgagcgc cgcctgcact tccggggacg       60

tgagcctagc ttccctgtag gcggcgcggg agggagaagt ttgcagggcc gtgctgggaa      120

gatcacctcc gctcccaatg tgagcagttt cccgaacgct ctttcggaga aggtttccca      180

gagaggtggt ggacgggaac atgaggcggc gtctcctcat cctgaccact ttggtgcctt      240

tcgtcctggc accccgacct ccggaggaag caggctctgg ctcccatccg cgacttgaga      300

agcttgattc tttgctctca gactacgaca tcctctcctt agctaatatt cagcagcact      360

ccataaggaa aagggatcta cagtctgcga cacacttaga aacattacta actttttcag      420

ctttgaaaag acattttaaa ttatacttga catcaagtac cgaacgcttt tcacaaaact      480

tgagagtcgt ggtggtggac gggaaagaag aaagcgagta cagcgtgaag tggcagaact      540

tcttcagtgg tcacgtggtt ggtgagcctg actctagggt tctagcccac ataggagatg      600

atgatgttac agtgagaatc aacacagatg gggcagaata taacgtagag ccactttgga      660

ggtttgtcaa tgatactaaa gataaacgaa tgctggtgta taagtctgaa gatatcaagg      720

atttttcacg tttgcagtct ccaaaagtat gtggttattt aaatgcagat agtgaagagc      780

tgcttccaaa agggctcata gacagagagc catctgaagt gcatacaaat tcatatagag      840

tttgttcgtc gagtgaagag acgagctgaa cctaacccct tgaagaatac ttgtaaatta      900

ctggtggtag cagatcatcg attttataaa tacatgggcc gtggagaaga gagcaccact      960

acaaattact taatagagct aattgaccga gttgatgaca tataccggaa cacgtcgtgg     1020

gataatgcag ggtttaaagg gtatggagtg cagatagagc agattcgaat tctcaagtct     1080

ccacaagagg taaaacctgg tgaaagacac ttcaatatgg caaaaagttt cccaaacgaa     1140

gagaaggatg cttgggatgt gaagatgcta ttagagcaat ttagctttga tatagctgaa     1200

gaagcatcta aagtctgcct ggctcatctt ttcacgtacc aggattttga tatgggaact     1260

cttggattag cttacgttgg ttctcccaga gcaaacagtc atggaggggt ttgtccaaaa     1320

gcttattaca acccaactgt gaagaaaaac atctatttaa atagtggtct gactagtact     1380

aaaaattatg gcaaaactat tctcacaaag gaagctgacc tggttacaac tcatgaattg     1440

ggacataatt ttggagcaga acatgaccct gatgggctag cagaatgtgc cccaaatgag     1500

gaccaaggag gaaagtatgt catgtatccc atagctgtga gcggtgacca cgagaataat     1560

aagatgtttt caaactgcag taaacagtcc atctacaaga ccatagaaag taaggctcaa     1620

gagtgcttcc aggagcgcag caacaaggtg tgtggcaact ccagggtgga tgaaggagag     1680

gagtgtgacc cgggtattat gtacctgaac aacgacacct gctgcaatag tgactgcaca     1740

ctgaagccgg gtgtgcagtg cagtgatagg aacagtcctt gctgtaaaaa ctgtcagttt     1800

gagacggcgc agaagaagtg ccaggaggct attaatgcta catgcaaagg agtgtcttac     1860

tgcacaggga atagcagtga gtgcccccca cccggagatg ctgaagatga cactgtgtgc     1920

ttggaccttg gcaagtgcaa ggctgggaaa tgcatccctt tctgcaagag ggagcaggag     1980

ctggagtcct gcgcatgcgt tgacactgac aactcgtgca aggtgtgctg caggaacctt     2040

tctggcccgt gtgtgccgta cgtcgatgca gagcaaaaga acttgttttt gaggaaaggg     2100

aagccatgta cagtagggtt ttgcgacatg aatggcaaat gtgagaaacg agtacaggac     2160

gtaattgagc gattttggga tttcattgac cagctgagca tcaacacttt tgggaagttt     2220

ctggcagata acatcgttgg gtctgttctg gttttctcct tgatattttg gattcctttc     2280

agcattcttg tccactgtgt ggataagaaa ctggacaagc agtatgaatc cctgtctctg     2340

tttcatcaca gtaacattga gatgctgagc agcatggact cagcatctgt tcgcatcatc     2400

aagccctttc ctgcacccca gactccaggt cgtctgcagg ccctgcagcc agctgccatg     2460

atgccgccag tacctgcagc tccaaaactg gaccaccaga ggatggacac catccaggaa     2520

gaccccagca cagactcaca tgcagatgat gacggttttg agaaggaccc cttccccaac     2580

agcagcacag ctgccaagtc ctttgaggat ctcacagacc acccagtcac caggagcgaa     2640

aaggcggcct cattcaagct gcagcgtcag agccgagttg acagcaaaga gacagagtgc     2700

tagtggggaa ccttggcctg ctctaggaca tatacctgca gatgttccat agagctgacc     2760

tgaatcaaaa catagattat aatgatctga gaaacgggga agcaacttag cagatgctgg     2820

tcatgtgcta tgaccttcac atgacatcct atgtatgtag gccctttgaa gaggtgaggt     2880

aaatctggct tatgtaaggc tttcaggttt tgggtttttc ttttataatc taaaatctcc     2940

tttgacctgt ggtgcagaag cagaaagtaa ggctggaccc cgttcctggt gacagtgctg     3000

ttaagtcttc agtctgtttt tctgtaccct ctgactacag tgaagcactt aacagtgagg     3060

ataactggaa cacagacata cttgtttgtt tgttttgttt ttgtttttgt tttttttttt     3120

ttgaccctca actaaaagag gagcaagaga aacctgcttg tatgttgtct ccaaatgcgg     3180

cctgtcttgg cactgaattc tttgtagatg gagagacctg cctacactta gggccatcta     3240

cattaagagc agtcctttcc aagaggaaca gtttatagaa acagccacat gaacttcgag     3300

atggcctatt aactgttcag ccccagattc actgggcagt ttttccattt tacaaatgtg     3360

tcgtctttaa actgtttgcc ttaaaaaaaa aaatcaatat tgggctggag agttggcccc     3420

acagttaaga gcagttggtc tcattctcag cacccacatg gtggctctca actctgtaac     3480

tccaatccca gaggagatga catcttctga actctaggac acgaggcata cattggtgca     3540

ggcaaaacaa agccaagtgc tgtaaaatgt ggcaataacc acaaaaccta tagtgcctca     3600

cagtatggac tgagtggtga atagacactc ttcccagaac cacttctgga caggccggga     3660

tgtgctggct ggctaggaag agggggtggg agtgggagag tggtgctgcc atcggggccc     3720

agccctagaa gaactgacct tcagtctcgg caagtagaca cccacgtgac ctctggctct     3780

ggtgcttcaa gatgttctgt acttactgtg tgaggaataa atgccattag cctgaattct     3840

gatttctata aattctagtt ataaatgctc ttttcttcta agaattgcag tgtgctcaca     3900

agccaacaca ttttaaccaa gataatttgt aaactctgag gacagttaac caagcctgtg     3960

ccttgtctct cctgaggacg cctgttacac taatacttga atatatacct tgtggtattt     4020

gctcttttta ctagtcatga tagtcttgta ttttaattac actttgatga tttgctatag     4080

ggagagtggg gtgtgtgggt atatgtatga atgaaacagt tggcagaata taagaaaacc     4140

atttttataa aattgtgact ttttaaacca aaattgtctt aattgtatta cttttttttt     4200

ctttggcatg tacagaatta ataagatgct cagggcatat tctatagctg tggcattgat     4260

gatacctgcc tcagtcaata aatactgaat atcaaagcag tggattgcgt atataacatt     4320

tccctgaaaa ataagttagt aggttttttg atcaataatc atgaacagaa gttaagcttg     4380

gaaaagacat ttaatcaatc tcttgatgtc tgtgaattac taataaagct acgcacatgt     4440

tcacagaatg tttgtggcta ccaacatgaa                                      4470


<210> 198
<211> 4451
<212> DNA
<213> Mus musculus

<400> 198
gctgcggccg gaaacgagtt aagccgctct cagcgagcgc cgcctgcact tccggggacg       60

tgagcctagc ttccctgtag gcggcgcggg agggagaagt ttgcagggcc gtgctgggaa      120

gatcacctcc gctcccaatg tgagcagttt cccgaacgct ctttcggaga aggtttccca      180

gagaggtggt ggacgggaac atgaggcggc gtctcctcat cctgaccact ttggtgcctt      240

tcgtcctggc accccgacct ccggaggaag caggctctgg ctcccatccg cgacttgaga      300

agcttgattc tttgctctca gactacgaca tcctctcctt agctaatatt cagcagcact      360

ccataaggaa aagggatcta cagtctgcga cacacttaga aacattacta actttttcag      420

ctttgaaaag acattttaaa ttatacttga catcaagtac cgaacgcttt tcacaaaact      480

tgagagtcgt ggtggtggac gggaaagaag aaagcgagta cagcgtgaag tggcagaact      540

tcttcagtgg tcacgtggtt ggtgagcctg actctagggt tctagcccac ataggagatg      600

atgatgttac agtgagaatc aacacagatg gggcagaata taacgtagag ccactttgga      660

ggtttgtcaa tgatactaaa gataaacgaa tgctggtgta taagtctgaa gatatcaagg      720

atttttcacg tttgcagtct ccaaaagtat gtggttattt aaatgcagat agtgaagagc      780

tgcttccaaa agggctcata gacagagagc catctgaaga gtttgttcgt cgagtgaaga      840

gacgagctga acctaacccc ttgaagaata cttgtaaatt actggtggta gcagatcatc      900

gattttataa atacatgggc cgtggagaag agagcaccac tacaaattac ttaatagagc      960

taattgaccg agttgatgac atataccgga acacgtcgtg ggataatgca gggtttaaag     1020

ggtatggagt gcagatagag cagattcgaa ttctcaagtc tccacaagag gtaaaacctg     1080

gtgaaagaca cttcaatatg gcaaaaagtt tcccaaacga agagaaggat gcttgggatg     1140

tgaagatgct attagagcaa tttagctttg atatagctga agaagcatct aaagtctgcc     1200

tggctcatct tttcacgtac caggattttg atatgggaac tcttggatta gcttacgttg     1260

gttctcccag agcaaacagt catggagggg tttgtccaaa agcttattac aacccaactg     1320

tgaagaaaaa catctattta aatagtggtc tgactagtac taaaaattat ggcaaaacta     1380

ttctcacaaa ggaagctgac ctggttacaa ctcatgaatt gggacataat tttggagcag     1440

aacatgaccc tgatgggcta gcagaatgtg ccccaaatga ggaccaagga ggaaagtatg     1500

tcatgtatcc catagctgtg agcggtgacc acgagaataa taagatgttt tcaaactgca     1560

gtaaacagtc catctacaag accatagaaa gtaaggctca agagtgcttc caggagcgca     1620

gcaacaaggt gtgtggcaac tccagggtgg atgaaggaga ggagtgtgac ccgggtatta     1680

tgtacctgaa caacgacacc tgctgcaata gtgactgcac actgaagccg ggtgtgcagt     1740

gcagtgatag gaacagtcct tgctgtaaaa actgtcagtt tgagacggcg cagaagaagt     1800

gccaggaggc tattaatgct acatgcaaag gagtgtctta ctgcacaggg aatagcagtg     1860

agtgcccccc acccggagat gctgaagatg acactgtgtg cttggacctt ggcaagtgca     1920

aggctgggaa atgcatccct ttctgcaaga gggagcagga gctggagtcc tgcgcatgcg     1980

ttgacactga caactcgtgc aaggtgtgct gcaggaacct ttctggcccg tgtgtgccgt     2040

acgtcgatgc agagcaaaag aacttgtttt tgaggaaagg gaagccatgt acagtagggt     2100

tttgcgacat gaatggcaaa tgtgagaaac gagtacagga cgtaattgag cgattttggg     2160

atttcattga ccagctgagc atcaacactt ttgggaagtt tctggcagat aacatcgttg     2220

ggtctgttct ggttttctcc ttgatatttt ggattccttt cagcattctt gtccactgtg     2280

tggataagaa actggacaag cagtatgaat ccctgtctct gtttcatcac agtaacattg     2340

agatgctgag cagcatggac tcagcatctg ttcgcatcat caagcccttt cctgcacccc     2400

agactccagg tcgtctgcag gccctgcagc cagctgccat gatgccgcca gtacctgcag     2460

ctccaaaact ggaccaccag aggatggaca ccatccagga agaccccagc acagactcac     2520

atgcagatga tgacggtttt gagaaggacc ccttccccaa cagcagcaca gctgccaagt     2580

cctttgagga tctcacagac cacccagtca ccaggagcga aaaggcggcc tcattcaagc     2640

tgcagcgtca gagccgagtt gacagcaaag agacagagtg ctagtgggga accttggcct     2700

gctctaggac atatacctgc agatgttcca tagagctgac ctgaatcaaa acatagatta     2760

taatgatctg agaaacgggg aagcaactta gcagatgctg gtcatgtgct atgaccttca     2820

catgacatcc tatgtatgta ggccctttga agaggtgagg taaatctggc ttatgtaagg     2880

ctttcaggtt ttgggttttt cttttataat ctaaaatctc ctttgacctg tggtgcagaa     2940

gcagaaagta aggctggacc ccgttcctgg tgacagtgct gttaagtctt cagtctgttt     3000

ttctgtaccc tctgactaca gtgaagcact taacagtgag gataactgga acacagacat     3060

acttgtttgt ttgttttgtt tttgtttttg tttttttttt tttgaccctc aactaaaaga     3120

ggagcaagag aaacctgctt gtatgttgtc tccaaatgcg gcctgtcttg gcactgaatt     3180

ctttgtagat ggagagacct gcctacactt agggccatct acattaagag cagtcctttc     3240

caagaggaac agtttataga aacagccaca tgaacttcga gatggcctat taactgttca     3300

gccccagatt cactgggcag tttttccatt ttacaaatgt gtcgtcttta aactgtttgc     3360

cttaaaaaaa aaaatcaata ttgggctgga gagttggccc cacagttaag agcagttggt     3420

ctcattctca gcacccacat ggtggctctc aactctgtaa ctccaatccc agaggagatg     3480

acatcttctg aactctagga cacgaggcat acattggtgc aggcaaaaca aagccaagtg     3540

ctgtaaaatg tggcaataac cacaaaacct atagtgcctc acagtatgga ctgagtggtg     3600

aatagacact cttcccagaa ccacttctgg acaggccggg atgtgctggc tggctaggaa     3660

gagggggtgg gagtgggaga gtggtgctgc catcggggcc cagccctaga agaactgacc     3720

ttcagtctcg gcaagtagac acccacgtga cctctggctc tggtgcttca agatgttctg     3780

tacttactgt gtgaggaata aatgccatta gcctgaattc tgatttctat aaattctagt     3840

tataaatgct cttttcttct aagaattgca gtgtgctcac aagccaacac attttaacca     3900

agataatttg taaactctga ggacagttaa ccaagcctgt gccttgtctc tcctgaggac     3960

gcctgttaca ctaatacttg aatatatacc ttgtggtatt tgctcttttt actagtcatg     4020

atagtcttgt attttaatta cactttgatg atttgctata gggagagtgg ggtgtgtggg     4080

tatatgtatg aatgaaacag ttggcagaat ataagaaaac catttttata aaattgtgac     4140

tttttaaacc aaaattgtct taattgtatt actttttttt tctttggcat gtacagaatt     4200

aataagatgc tcagggcata ttctatagct gtggcattga tgatacctgc ctcagtcaat     4260

aaatactgaa tatcaaagca gtggattgcg tatataacat ttccctgaaa aataagttag     4320

taggtttttt gatcaataat catgaacaga agttaagctt ggaaaagaca tttaatcaat     4380

ctcttgatgt ctgtgaatta ctaataaagc tacgcacatg ttcacagaat gtttgtggct     4440

accaacatga a                                                          4451


