                         SEQUENCE LISTING

<110>  GENTICEL
 
<120>  IMMUNOTHERAPEUTIC VACCINE COMPRISING E7 PROTEINS OF HPV16 AND 
       HPV18 FUSED WITH CyaA, FOR USE IN SUBJECTS INFECTED WITH HPV

<130>  B11000A - AD/KN

<140>  PCT/EPXXXXXX
<141>  2015-12-22

<150>  EP 14307153.8
<151>  2014-12-23

<160>  99    

<170>  PatentIn version 3.5

<210>  1
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1
cgtcgcaggc gtaaacg                                                      17


<210>  2
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2
acaggaggca ggtacac                                                      17


<210>  3
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3
agatgtccgt gtggcgg                                                      17


<210>  4
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4
cgagcaatta ggagagtcag agg                                               23


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5
tgtgtgacgc tgtggttcat                                                   20


<210>  6
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6
aacccgacca tgcagtt                                                      17


<210>  7
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7
acgattccac aacataggag ga                                                22


<210>  8
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8
tacacttggg tttcagtacg aggt                                              24


<210>  9
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9
ctccaacatg ctatgcaacg tcc                                               23


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10
agctcagagg aggaggatga a                                                 21


<210>  11
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11
ggttacaata ttgtaatggg ctc                                               23


<210>  12
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12
cagctggaca agcaga                                                       16


<210>  13
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  13
ccgacgagcc gaacca                                                       16


<210>  14
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  14
ctcaattctg gcttcacact tacaa                                             25


<210>  15
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  15
aacgtcacac aatgtt                                                       16


<210>  16
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  16
tgcatttgac tcctgaggag aa                                                22


<210>  17
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  17
gggcctcacc accaacttc                                                    19


<210>  18
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  18
ctgccgttac tgccct                                                       16


<210>  19
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  19
cgtcgggctg gtagttgtg                                                    19


<210>  20
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  20
attgcatttg gaacctcaga atg                                               23


<210>  21
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  21
atgactaact ccatctgc                                                     18


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  22
ccaaagagga cctgcgtgtt                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  23
tacttgatgc gcagagtggg                                                   20


<210>  24
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  24
tacaacagct gcttatgg                                                     18


<210>  25
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  25
acaacagcgt cacacaattc agt                                               23


<210>  26
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  26
cagttctacg ttccgcaggt t                                                 21


<210>  27
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  27
actgcaacta gtagtagaag cgtcgcggg                                         29


<210>  28
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  28
tgtgcggcgt gttgga                                                       16


<210>  29
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  29
tggcgttttt acacgtcaca gt                                                22


<210>  30
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  30
cccgacgtag agaaa                                                        15


<210>  31
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  31
gtgtggaccg gccagatg                                                     18


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  32
cgtcgcagtg ctatgaatgc                                                   20


<210>  33
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  33
acaagcagaa caagcc                                                       16


<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  34
ccacggacat tgcatgattt g                                                 21


<210>  35
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  35
ctttttgcat tcaacgcatt tca                                               23


<210>  36
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  36
tggagacatc tgtgcatgaa atcgaa                                            26


<210>  37
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  37
tgtgctacga gcaattacct gact                                              24


<210>  38
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  38
tgattaactc catctggttc atcttt                                            26


<210>  39
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  39
cgactccgag aatga                                                        15


<210>  40
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  40
aaaaaccgct gtgtccagtt g                                                 21


<210>  41
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  41
cacctcggtt tctctacgtg ttg                                               23


<210>  42
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  42
attccataac atcggtggac ggt                                               23


<210>  43
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  43
gttcataaag ctaaattgta cgtggaa                                           27


<210>  44
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  44
tgtgaatctt gtccgtccac tt                                                22


<210>  45
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  45
acaatatcct ttagggtaac atgtcttcca tgcatg                                 36


<210>  46
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  46
aaagcaaaaa ttggtggacg a                                                 21


<210>  47
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  47
tgccagcaat tagcgcatt                                                    19


<210>  48
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  48
catgaaatag cgggacgttg gacg                                              24


<210>  49
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  49
aacggtttca caaaatttca catatg                                            26


<210>  50
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  50
tgattcagtt gctgttgtgt gtct                                              24


<210>  51
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  51
accgggtcgt gcctgacatg c                                                 21


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  52
gtccgttaac accggaggaa                                                   20


<210>  53
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  53
cccggtccat gcatatgc                                                     18


<210>  54
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  54
aacaattgca ctgtgaacat aaaagacgat ttcatt                                 36


<210>  55
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  55
gcttcataaa actaaataac cagtggaa                                          28


<210>  56
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  56
tcaggaggct gcaggtctag tac                                               23


<210>  57
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  57
cgttgcttac actgctg                                                      17


<210>  58
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  58
cattgaccac acggacaaaa ag                                                22


<210>  59
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  59
cgaagtgctc gaatgcga                                                     18


<210>  60
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  60
tcatttcgga tggtcaagca gcca                                              24


<210>  61
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of E7 of HPV16

<400>  61

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
                85                  90                  95      


Lys Pro 
        


<210>  62
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of E7 of HPV18

<400>  62

Met His Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu 
1               5                   10                  15      


Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser 
            20                  25                  30          


Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His 
        35                  40                  45              


Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met 
    50                  55                  60                  


Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala 
65                  70                  75                  80  


Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe 
                85                  90                  95      


Val Cys Pro Trp Cys Ala Ser Gln Gln 
            100                 105 


<210>  63
<211>  5121
<212>  DNA
<213>  Bordetella pertussis (wild type CyaA)


<220>
<221>  CDS
<222>  (1)..(5121)

<400>  63
atg cag caa tcg cat cag gct ggt tac gca aac gcc gcc gac cgg gag         48
Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu           
1               5                   10                  15                

tct ggc atc ccc gca gcc gta ctc gat ggc atc aag gcc gtg gcg aag         96
Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys           
            20                  25                  30                    

gaa aaa aac gcc aca ttg atg ttc cgc ctg gtc aac ccc cat tcc acc        144
Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr           
        35                  40                  45                        

agc ctg att gcc gaa ggg gtg gcc acc aaa gga ttg ggc gtg cac gcc        192
Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala           
    50                  55                  60                            

aag tcg tcc gat tgg ggg ttg cag gcg ggc tac att ccc gtc aac ccg        240
Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro           
65                  70                  75                  80            

aat ctt tcc aaa ctg ttc ggc cgt gcg ccc gag gtg atc gcg cgg gcc        288
Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala           
                85                  90                  95                

gac aac gac gtc aac agc agc ctg gcg cat ggc cat acc gcg gtc gac        336
Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp           
            100                 105                 110                   

ctg acg ctg tcg aaa gag cgg ctt gac tat ctg cgg caa gcg ggc ctg        384
Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu           
        115                 120                 125                       

gtc acc ggc atg gcc gat ggc gtg gtc gcg agc aac cac gca ggc tac        432
Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr           
    130                 135                 140                           

gag cag ttc gag ttt cgc gtg aag gaa acc tcg gac ggg cgc tat gcc        480
Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala           
145                 150                 155                 160           

gtg cag tat cgc cgc aag ggc ggc gac gat ttc gag gcg gtc aag gtg        528
Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val           
                165                 170                 175               

atc ggc aat gcc gcc ggt att cca ctg acg gcg gat atc gac atg ttc        576
Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Ile Asp Met Phe           
            180                 185                 190                   

gcc att atg ccg cat ctg tcc aac ttc cgc gac tcg gcg cgc agt tcg        624
Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg Ser Ser           
        195                 200                 205                       

gtg acc agc ggc gat tcg gtg acc gat tac ctg gcg cgc acg cgg cgg        672
Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr Arg Arg           
    210                 215                 220                           

gcc gcc agc gag gcc acg ggc ggc ctg gat cgc gaa cgc atc gac ttg        720
Ala Ala Ser Glu Ala Thr Gly Gly Leu Asp Arg Glu Arg Ile Asp Leu           
225                 230                 235                 240           

ttg tgg aaa atc gct cgc gcc ggc gcc cgt tcc gca gtg ggc acc gag        768
Leu Trp Lys Ile Ala Arg Ala Gly Ala Arg Ser Ala Val Gly Thr Glu           
                245                 250                 255               

gcg cgt cgc cag ttc cgc tac gac ggc gac atg aat atc ggc gtg atc        816
Ala Arg Arg Gln Phe Arg Tyr Asp Gly Asp Met Asn Ile Gly Val Ile           
            260                 265                 270                   

acc gat ttc gag ctg gaa gtg cgc aat gcg ctg aac agg cgg gcg cac        864
Thr Asp Phe Glu Leu Glu Val Arg Asn Ala Leu Asn Arg Arg Ala His           
        275                 280                 285                       

gcc gtc ggc gcg cag gac gtg gtc cag cat ggc act gag cag aac aat        912
Ala Val Gly Ala Gln Asp Val Val Gln His Gly Thr Glu Gln Asn Asn           
    290                 295                 300                           

cct ttc ccg gag gca gat gag aag att ttc gtc gta tcg gcc acc ggt        960
Pro Phe Pro Glu Ala Asp Glu Lys Ile Phe Val Val Ser Ala Thr Gly           
305                 310                 315                 320           

gaa agc cag atg ctc acg cgc ggg caa ctg aag gaa tac att ggc cag       1008
Glu Ser Gln Met Leu Thr Arg Gly Gln Leu Lys Glu Tyr Ile Gly Gln           
                325                 330                 335               

cag cgc ggc gag ggc tat gtc ttc tac gag aac cgt gca tac ggc gtg       1056
Gln Arg Gly Glu Gly Tyr Val Phe Tyr Glu Asn Arg Ala Tyr Gly Val           
            340                 345                 350                   

gcg ggg aaa agc ctg ttc gac gat ggg ctg gga gcc gcg ccc ggc gtg       1104
Ala Gly Lys Ser Leu Phe Asp Asp Gly Leu Gly Ala Ala Pro Gly Val           
        355                 360                 365                       

ccg agc gga cgt tcg aag ttc tcg ccg gat gta ctg gaa acg gtg ccg       1152
Pro Ser Gly Arg Ser Lys Phe Ser Pro Asp Val Leu Glu Thr Val Pro           
    370                 375                 380                           

gcg tca ccc gga ttg cgg cgg ccg tcg ctg ggc gca gtg gaa cgc cag       1200
Ala Ser Pro Gly Leu Arg Arg Pro Ser Leu Gly Ala Val Glu Arg Gln           
385                 390                 395                 400           

gat tcc ggc tat gac agc ctt gat ggg gtg gga tcg cga tcg ttc tcg       1248
Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly Ser Arg Ser Phe Ser           
                405                 410                 415               

ttg ggc gag gtg tcc gac atg gcc gcc gtg gaa gcg gcg gaa ctg gaa       1296
Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu Ala Ala Glu Leu Glu           
            420                 425                 430                   

atg acc cgg caa gtc ttg cac gcc ggg gcg cgg cag gac gat gcc gag       1344
Met Thr Arg Gln Val Leu His Ala Gly Ala Arg Gln Asp Asp Ala Glu           
        435                 440                 445                       

ccg ggc gtg agc ggt gcg tcg gcg cac tgg ggg cag cgg gcg ctg cag       1392
Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly Gln Arg Ala Leu Gln           
    450                 455                 460                           

ggc gcc cag gcg gtg gcg gcg gcg cag cgg ctg gtt cat gcc att gcc       1440
Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu Val His Ala Ile Ala           
465                 470                 475                 480           

ctg atg acg caa ttc ggc cgg gcc ggt tcc acc aac acg ccg cag gaa       1488
Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr Asn Thr Pro Gln Glu           
                485                 490                 495               

gcg gcc tcg ttg tcg gcg gcc gtg ttc ggc ttg ggc gag gcc agc agc       1536
Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu Gly Glu Ala Ser Ser           
            500                 505                 510                   

gcc gtg gcc gaa acc gtg agc ggt ttt ttc cgc ggg tct tcg cgc tgg       1584
Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg Gly Ser Ser Arg Trp           
        515                 520                 525                       

gcc ggc ggt ttc ggc gtg gct ggc ggc gcg atg gcg ctg gga ggc ggc       1632
Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met Ala Leu Gly Gly Gly           
    530                 535                 540                           

atc gcc gcg gcc gtt ggc gcc ggg atg tcg ttg acc gat gac gcg ccg       1680
Ile Ala Ala Ala Val Gly Ala Gly Met Ser Leu Thr Asp Asp Ala Pro           
545                 550                 555                 560           

gcc gga cag aag gcc gcc gcc ggc gcc gag atc gcg ctg cag ttg aca       1728
Ala Gly Gln Lys Ala Ala Ala Gly Ala Glu Ile Ala Leu Gln Leu Thr           
                565                 570                 575               

ggt gga acg gtc gag ctg gct tct tcc atc gcg ttg gcg ctg gcc gcg       1776
Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala Leu Ala Leu Ala Ala           
            580                 585                 590                   

gcg cgc ggc gtg acc agc ggc ttg cag gtg gcc ggg gcg tcg gcc ggg       1824
Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala Gly Ala Ser Ala Gly           
        595                 600                 605                       

gcg gct gcc ggc gca ttg gcc gcg gcg ctc agt ccc atg gag atc tac       1872
Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser Pro Met Glu Ile Tyr           
    610                 615                 620                           

ggc ctg gtg cag caa tcg cac tat gcg gat cag ctg gac aag ctg gcg       1920
Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln Leu Asp Lys Leu Ala           
625                 630                 635                 640           

cag gaa tcg agc gca tac ggt tac gag ggc gac gcc ttg ctg gcc cag       1968
Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp Ala Leu Leu Ala Gln           
                645                 650                 655               

ctg tat cgc gac aag acg gcc gcc gag ggc gcc gtc gcc ggc gtc tcc       2016
Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala Val Ala Gly Val Ser           
            660                 665                 670                   

gcc gtc ctg agc acg gtg ggg gcg gcg gtg tcg atc gcc gcg gcg gcc       2064
Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser Ile Ala Ala Ala Ala           
        675                 680                 685                       

agc gtg gta ggg gcc ccg gtg gcg gtg gtc act tcc ttg ctg acc ggg       2112
Ser Val Val Gly Ala Pro Val Ala Val Val Thr Ser Leu Leu Thr Gly           
    690                 695                 700                           

gct ctc aac ggc atc ctg cgc ggc gtg cag cag ccc atc atc gaa aag       2160
Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln Pro Ile Ile Glu Lys           
705                 710                 715                 720           

ctg gcc aac gat tac gct cgc aag atc gac gag ctg ggc ggg ccg caa       2208
Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu Leu Gly Gly Pro Gln           
                725                 730                 735               

gcg tac ttc gag aaa aac ctg cag gcg cgt cac gaa caa ctg gcc aat       2256
Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His Glu Gln Leu Ala Asn           
            740                 745                 750                   

tcg gac ggc cta cgg aaa atg ctg gcc gac ctg cag gcc ggt tgg aac       2304
Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu Gln Ala Gly Trp Asn           
        755                 760                 765                       

gcc agc agc gtg atc ggg gtg cag acg aca gag atc tcc aag tcg gcg       2352
Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu Ile Ser Lys Ser Ala           
    770                 775                 780                           

ctc gaa ctg gcc gcc att acc ggc aac gcg gac aac ctg aaa tcc gtc       2400
Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp Asn Leu Lys Ser Val           
785                 790                 795                 800           

gac gtg ttc gtg gac cgc ttc gtc cag ggc gag cgg gtg gcc ggc cag       2448
Asp Val Phe Val Asp Arg Phe Val Gln Gly Glu Arg Val Ala Gly Gln           
                805                 810                 815               

ccg gtg gtc ctc gac gtc gcc gcc ggc ggc atc gat atc gcc agc cgc       2496
Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile Asp Ile Ala Ser Arg           
            820                 825                 830                   

aag ggc gag cgg ccg gcg ctg acg ttc atc acg ccg ctg gcc gcg cca       2544
Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr Pro Leu Ala Ala Pro           
        835                 840                 845                       

gga gaa gag cag cgc cgg cgc acg aaa acg ggc aag agc gaa ttc acc       2592
Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly Lys Ser Glu Phe Thr           
    850                 855                 860                           

aca ttc gtc gag atc gtg ggc aag cag gac cgc tgg cgc atc cgg gac       2640
Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg Trp Arg Ile Arg Asp           
865                 870                 875                 880           

ggc gcg gcc gac acc acc atc gat ctg gcc aag gtg gtg tcg caa ctg       2688
Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys Val Val Ser Gln Leu           
                885                 890                 895               

gtc gac gcc aat ggc gtg ctc aag cac agc atc aaa ctg gat gtg atc       2736
Val Asp Ala Asn Gly Val Leu Lys His Ser Ile Lys Leu Asp Val Ile           
            900                 905                 910                   

ggc gga gat ggc gat gac gtc gtg ctt gcc aat gct tcg cgc atc cat       2784
Gly Gly Asp Gly Asp Asp Val Val Leu Ala Asn Ala Ser Arg Ile His           
        915                 920                 925                       

tat gac ggc ggc gcg ggc acc aac acg gtc agc tat gcc gcc ctg ggt       2832
Tyr Asp Gly Gly Ala Gly Thr Asn Thr Val Ser Tyr Ala Ala Leu Gly           
    930                 935                 940                           

cga cag gat tcc att acc gtg tcc gcc gac ggg gaa cgt ttc aac gtg       2880
Arg Gln Asp Ser Ile Thr Val Ser Ala Asp Gly Glu Arg Phe Asn Val           
945                 950                 955                 960           

cgc aag cag ttg aac aac gcc aac gtg tat cgc gaa ggc gtg gct acc       2928
Arg Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg Glu Gly Val Ala Thr           
                965                 970                 975               

cag aca acc gcc tac ggc aag cgc acg gag aat gtc caa tac cgc cat       2976
Gln Thr Thr Ala Tyr Gly Lys Arg Thr Glu Asn Val Gln Tyr Arg His           
            980                 985                 990                   

gtc gag ctg gcc cgt gtc ggg caa  ctg gtg gag gtc gac  acg ctc gag     3024
Val Glu Leu Ala Arg Val Gly Gln  Leu Val Glu Val Asp  Thr Leu Glu         
        995                 1000                 1005                     

cat gtg  cag cac atc atc ggc  ggg gcc ggc aac gat  tcg atc acc        3069
His Val  Gln His Ile Ile Gly  Gly Ala Gly Asn Asp  Ser Ile Thr            
    1010                 1015                 1020                        

ggc aat  gcg cac gac aac ttc  cta gcc ggc ggg tcg  ggc gac gac        3114
Gly Asn  Ala His Asp Asn Phe  Leu Ala Gly Gly Ser  Gly Asp Asp            
    1025                 1030                 1035                        

agg ctg  gat ggc ggc gcc ggc  aac gac acc ctg gtt  ggc ggc gag        3159
Arg Leu  Asp Gly Gly Ala Gly  Asn Asp Thr Leu Val  Gly Gly Glu            
    1040                 1045                 1050                        

ggc caa  aac acg gtc atc ggc  ggc gcc ggc gac gac  gta ttc ctg        3204
Gly Gln  Asn Thr Val Ile Gly  Gly Ala Gly Asp Asp  Val Phe Leu            
    1055                 1060                 1065                        

cag gac  ctg ggg gta tgg agc  aac cag ctc gat ggc  ggc gcg ggc        3249
Gln Asp  Leu Gly Val Trp Ser  Asn Gln Leu Asp Gly  Gly Ala Gly            
    1070                 1075                 1080                        

gtc gat  acc gtg aag tac aac  gtg cac cag cct tcc  gag gag cgc        3294
Val Asp  Thr Val Lys Tyr Asn  Val His Gln Pro Ser  Glu Glu Arg            
    1085                 1090                 1095                        

ctc gaa  cgc atg ggc gac acg  ggc atc cat gcc gat  ctt caa aag        3339
Leu Glu  Arg Met Gly Asp Thr  Gly Ile His Ala Asp  Leu Gln Lys            
    1100                 1105                 1110                        

ggc acg  gtc gag aag tgg ccg  gcc ctg aac ctg ttc  agc gtc gac        3384
Gly Thr  Val Glu Lys Trp Pro  Ala Leu Asn Leu Phe  Ser Val Asp            
    1115                 1120                 1125                        

cat gtc  aag aat atc gag aat  ctg cac ggc tcc cgc  ctg aac gac        3429
His Val  Lys Asn Ile Glu Asn  Leu His Gly Ser Arg  Leu Asn Asp            
    1130                 1135                 1140                        

cgc atc  gcc ggc gac gac cag  gac aac gag ctc tgg  ggc cac gat        3474
Arg Ile  Ala Gly Asp Asp Gln  Asp Asn Glu Leu Trp  Gly His Asp            
    1145                 1150                 1155                        

ggc aac  gac acg ata cgc ggc  cgg ggc ggc gac gac  atc ctg cgc        3519
Gly Asn  Asp Thr Ile Arg Gly  Arg Gly Gly Asp Asp  Ile Leu Arg            
    1160                 1165                 1170                        

ggc ggc  ctg ggc ctg gac acg  ctg tat ggc gag gac  ggc aac gac        3564
Gly Gly  Leu Gly Leu Asp Thr  Leu Tyr Gly Glu Asp  Gly Asn Asp            
    1175                 1180                 1185                        

atc ttc  ctg cag gac gac gag  acc gtc agc gat gac  atc gac ggc        3609
Ile Phe  Leu Gln Asp Asp Glu  Thr Val Ser Asp Asp  Ile Asp Gly            
    1190                 1195                 1200                        

ggc gcg  ggg ctg gac acc gtc  gac tac tcc gcc atg  atc cat cca        3654
Gly Ala  Gly Leu Asp Thr Val  Asp Tyr Ser Ala Met  Ile His Pro            
    1205                 1210                 1215                        

ggc agg  atc gtt gcg ccg cat  gaa tac ggc ttc ggg  atc gag gcg        3699
Gly Arg  Ile Val Ala Pro His  Glu Tyr Gly Phe Gly  Ile Glu Ala            
    1220                 1225                 1230                        

gac ctg  tcc agg gaa tgg gtg  cgc aag gcg tcc gcg  ctg ggc gtg        3744
Asp Leu  Ser Arg Glu Trp Val  Arg Lys Ala Ser Ala  Leu Gly Val            
    1235                 1240                 1245                        

gac tat  tac gat aat gtc cgc  aat gtc gaa aac gtc  atc ggt acg        3789
Asp Tyr  Tyr Asp Asn Val Arg  Asn Val Glu Asn Val  Ile Gly Thr            
    1250                 1255                 1260                        

agc atg  aag gat gtg ctc atc  ggc gac gcg caa gcc  aat acc ctg        3834
Ser Met  Lys Asp Val Leu Ile  Gly Asp Ala Gln Ala  Asn Thr Leu            
    1265                 1270                 1275                        

atg ggc  cag ggc ggc gac gat  acc gtg cgc ggc ggc  gac ggc gat        3879
Met Gly  Gln Gly Gly Asp Asp  Thr Val Arg Gly Gly  Asp Gly Asp            
    1280                 1285                 1290                        

gat ctg  ctg ttc ggc ggc gac  ggc aac gac atg ctg  tat ggc gac        3924
Asp Leu  Leu Phe Gly Gly Asp  Gly Asn Asp Met Leu  Tyr Gly Asp            
    1295                 1300                 1305                        

gcc ggc  aac gac acc ctc tac  ggg ggg ctg ggc gac  gat acc ctt        3969
Ala Gly  Asn Asp Thr Leu Tyr  Gly Gly Leu Gly Asp  Asp Thr Leu            
    1310                 1315                 1320                        

gaa ggc  ggc gcg ggc aac gat  tgg ttc ggc cag acg  cag gcg cgc        4014
Glu Gly  Gly Ala Gly Asn Asp  Trp Phe Gly Gln Thr  Gln Ala Arg            
    1325                 1330                 1335                        

gag cat  gac gtg ctg cgc ggc  gga gat ggg gtg gat  acc gtc gat        4059
Glu His  Asp Val Leu Arg Gly  Gly Asp Gly Val Asp  Thr Val Asp            
    1340                 1345                 1350                        

tac agc  cag acc ggc gcg cat  gcc ggc att gcc gcg  ggt cgc atc        4104
Tyr Ser  Gln Thr Gly Ala His  Ala Gly Ile Ala Ala  Gly Arg Ile            
    1355                 1360                 1365                        

ggg ctg  ggc atc ctg gct gac  ctg ggc gcc ggc cgc  gtc gac aag        4149
Gly Leu  Gly Ile Leu Ala Asp  Leu Gly Ala Gly Arg  Val Asp Lys            
    1370                 1375                 1380                        

ctg ggc  gag gcc ggc agc agc  gcc tac gat acg gtt  tcc ggt atc        4194
Leu Gly  Glu Ala Gly Ser Ser  Ala Tyr Asp Thr Val  Ser Gly Ile            
    1385                 1390                 1395                        

gag aac  gtg gtg ggc acg gaa  ctg gcc gac cgc atc  acg ggc gat        4239
Glu Asn  Val Val Gly Thr Glu  Leu Ala Asp Arg Ile  Thr Gly Asp            
    1400                 1405                 1410                        

gcg cag  gcc aac gtg ctg cgc  ggc gcg ggt ggc gcc  gac gtg ctt        4284
Ala Gln  Ala Asn Val Leu Arg  Gly Ala Gly Gly Ala  Asp Val Leu            
    1415                 1420                 1425                        

gcg ggc  ggc gag ggc gac gat  gtg ctg ctg ggc ggc  gac ggc gac        4329
Ala Gly  Gly Glu Gly Asp Asp  Val Leu Leu Gly Gly  Asp Gly Asp            
    1430                 1435                 1440                        

gac cag  ctg tcg ggc gac gcc  gga cgc gat cgc ttg  tac ggc gaa        4374
Asp Gln  Leu Ser Gly Asp Ala  Gly Arg Asp Arg Leu  Tyr Gly Glu            
    1445                 1450                 1455                        

gcc ggt  gac gac tgg ttc ttc  cag gat gcc gcc aat  gcc ggc aat        4419
Ala Gly  Asp Asp Trp Phe Phe  Gln Asp Ala Ala Asn  Ala Gly Asn            
    1460                 1465                 1470                        

ctg ctc  gac ggc ggc gac ggc  cgc gat acc gtg gat  ttc agc ggc        4464
Leu Leu  Asp Gly Gly Asp Gly  Arg Asp Thr Val Asp  Phe Ser Gly            
    1475                 1480                 1485                        

ccg ggc  cgg ggc ctc gac gcc  ggc gca aag ggc gta  ttc ctg agc        4509
Pro Gly  Arg Gly Leu Asp Ala  Gly Ala Lys Gly Val  Phe Leu Ser            
    1490                 1495                 1500                        

ttg ggc  aag ggg ttc gcc agc  ctg atg gac gaa ccc  gaa acc agc        4554
Leu Gly  Lys Gly Phe Ala Ser  Leu Met Asp Glu Pro  Glu Thr Ser            
    1505                 1510                 1515                        

aac gtg  ttg cgc aat atc gag  aac gcc gtg ggc agc  gcg cgt gat        4599
Asn Val  Leu Arg Asn Ile Glu  Asn Ala Val Gly Ser  Ala Arg Asp            
    1520                 1525                 1530                        

gac gtg  ctg atc ggc gac gca  ggc gcc aac gtc ctc  aat ggc ctg        4644
Asp Val  Leu Ile Gly Asp Ala  Gly Ala Asn Val Leu  Asn Gly Leu            
    1535                 1540                 1545                        

gcg ggc  aac gac gtg ctg tcc  ggc ggc gct ggc gac  gat gtg ctg        4689
Ala Gly  Asn Asp Val Leu Ser  Gly Gly Ala Gly Asp  Asp Val Leu            
    1550                 1555                 1560                        

ctg ggc  gac gag ggc tcg gac  ctg ctc agc ggc gat  gcg ggc aac        4734
Leu Gly  Asp Glu Gly Ser Asp  Leu Leu Ser Gly Asp  Ala Gly Asn            
    1565                 1570                 1575                        

gac gat  ctg ttc ggc ggg cag  ggc gat gat act tat  ctg ttc ggg        4779
Asp Asp  Leu Phe Gly Gly Gln  Gly Asp Asp Thr Tyr  Leu Phe Gly            
    1580                 1585                 1590                        

gtc ggg  tac ggg cac gac acg  atc tac gaa tcg ggc  ggc ggc cat        4824
Val Gly  Tyr Gly His Asp Thr  Ile Tyr Glu Ser Gly  Gly Gly His            
    1595                 1600                 1605                        

gac acc  atc cgc atc aac gcg  ggg gcg gac cag ctg  tgg ttc gcg        4869
Asp Thr  Ile Arg Ile Asn Ala  Gly Ala Asp Gln Leu  Trp Phe Ala            
    1610                 1615                 1620                        

cgc cag  ggc aac gac ctg gag  atc cgc att ctc ggc  acc gac gat        4914
Arg Gln  Gly Asn Asp Leu Glu  Ile Arg Ile Leu Gly  Thr Asp Asp            
    1625                 1630                 1635                        

gca ctt  acc gtg cac gac tgg  tat cgc gac gcc gat  cac cgg gtg        4959
Ala Leu  Thr Val His Asp Trp  Tyr Arg Asp Ala Asp  His Arg Val            
    1640                 1645                 1650                        

gaa atc  atc cat gcc gcc aac  cag gcg gta gac cag  gca ggc atc        5004
Glu Ile  Ile His Ala Ala Asn  Gln Ala Val Asp Gln  Ala Gly Ile            
    1655                 1660                 1665                        

gaa aag  ctg gtc gag gca atg  gcg cag tat ccg gac  ccc ggc gcg        5049
Glu Lys  Leu Val Glu Ala Met  Ala Gln Tyr Pro Asp  Pro Gly Ala            
    1670                 1675                 1680                        

gcg gcg  gct gcc ccg ccg gcg  gcg cgc gtg ccg gac  acg ctg atg        5094
Ala Ala  Ala Ala Pro Pro Ala  Ala Arg Val Pro Asp  Thr Leu Met            
    1685                 1690                 1695                        

cag tcc  ctg gct gtc aac tgg  cgc tga                                 5121
Gln Ser  Leu Ala Val Asn Trp  Arg                                         
    1700                 1705                                             


<210>  64
<211>  1706
<212>  PRT
<213>  Bordetella pertussis (wild type CyaA)

<400>  64

Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu 
1               5                   10                  15      


Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys 
            20                  25                  30          


Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr 
        35                  40                  45              


Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala 
    50                  55                  60                  


Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro 
65                  70                  75                  80  


Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala 
                85                  90                  95      


Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp 
            100                 105                 110         


Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu 
        115                 120                 125             


Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr 
    130                 135                 140                 


Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala 
145                 150                 155                 160 


Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val 
                165                 170                 175     


Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Ile Asp Met Phe 
            180                 185                 190         


Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg Ser Ser 
        195                 200                 205             


Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr Arg Arg 
    210                 215                 220                 


Ala Ala Ser Glu Ala Thr Gly Gly Leu Asp Arg Glu Arg Ile Asp Leu 
225                 230                 235                 240 


Leu Trp Lys Ile Ala Arg Ala Gly Ala Arg Ser Ala Val Gly Thr Glu 
                245                 250                 255     


Ala Arg Arg Gln Phe Arg Tyr Asp Gly Asp Met Asn Ile Gly Val Ile 
            260                 265                 270         


Thr Asp Phe Glu Leu Glu Val Arg Asn Ala Leu Asn Arg Arg Ala His 
        275                 280                 285             


Ala Val Gly Ala Gln Asp Val Val Gln His Gly Thr Glu Gln Asn Asn 
    290                 295                 300                 


Pro Phe Pro Glu Ala Asp Glu Lys Ile Phe Val Val Ser Ala Thr Gly 
305                 310                 315                 320 


Glu Ser Gln Met Leu Thr Arg Gly Gln Leu Lys Glu Tyr Ile Gly Gln 
                325                 330                 335     


Gln Arg Gly Glu Gly Tyr Val Phe Tyr Glu Asn Arg Ala Tyr Gly Val 
            340                 345                 350         


Ala Gly Lys Ser Leu Phe Asp Asp Gly Leu Gly Ala Ala Pro Gly Val 
        355                 360                 365             


Pro Ser Gly Arg Ser Lys Phe Ser Pro Asp Val Leu Glu Thr Val Pro 
    370                 375                 380                 


Ala Ser Pro Gly Leu Arg Arg Pro Ser Leu Gly Ala Val Glu Arg Gln 
385                 390                 395                 400 


Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly Ser Arg Ser Phe Ser 
                405                 410                 415     


Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu Ala Ala Glu Leu Glu 
            420                 425                 430         


Met Thr Arg Gln Val Leu His Ala Gly Ala Arg Gln Asp Asp Ala Glu 
        435                 440                 445             


Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly Gln Arg Ala Leu Gln 
    450                 455                 460                 


Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu Val His Ala Ile Ala 
465                 470                 475                 480 


Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr Asn Thr Pro Gln Glu 
                485                 490                 495     


Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu Gly Glu Ala Ser Ser 
            500                 505                 510         


Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg Gly Ser Ser Arg Trp 
        515                 520                 525             


Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met Ala Leu Gly Gly Gly 
    530                 535                 540                 


Ile Ala Ala Ala Val Gly Ala Gly Met Ser Leu Thr Asp Asp Ala Pro 
545                 550                 555                 560 


Ala Gly Gln Lys Ala Ala Ala Gly Ala Glu Ile Ala Leu Gln Leu Thr 
                565                 570                 575     


Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala Leu Ala Leu Ala Ala 
            580                 585                 590         


Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala Gly Ala Ser Ala Gly 
        595                 600                 605             


Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser Pro Met Glu Ile Tyr 
    610                 615                 620                 


Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln Leu Asp Lys Leu Ala 
625                 630                 635                 640 


Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp Ala Leu Leu Ala Gln 
                645                 650                 655     


Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala Val Ala Gly Val Ser 
            660                 665                 670         


Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser Ile Ala Ala Ala Ala 
        675                 680                 685             


Ser Val Val Gly Ala Pro Val Ala Val Val Thr Ser Leu Leu Thr Gly 
    690                 695                 700                 


Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln Pro Ile Ile Glu Lys 
705                 710                 715                 720 


Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu Leu Gly Gly Pro Gln 
                725                 730                 735     


Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His Glu Gln Leu Ala Asn 
            740                 745                 750         


Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu Gln Ala Gly Trp Asn 
        755                 760                 765             


Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu Ile Ser Lys Ser Ala 
    770                 775                 780                 


Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp Asn Leu Lys Ser Val 
785                 790                 795                 800 


Asp Val Phe Val Asp Arg Phe Val Gln Gly Glu Arg Val Ala Gly Gln 
                805                 810                 815     


Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile Asp Ile Ala Ser Arg 
            820                 825                 830         


Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr Pro Leu Ala Ala Pro 
        835                 840                 845             


Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly Lys Ser Glu Phe Thr 
    850                 855                 860                 


Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg Trp Arg Ile Arg Asp 
865                 870                 875                 880 


Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys Val Val Ser Gln Leu 
                885                 890                 895     


Val Asp Ala Asn Gly Val Leu Lys His Ser Ile Lys Leu Asp Val Ile 
            900                 905                 910         


Gly Gly Asp Gly Asp Asp Val Val Leu Ala Asn Ala Ser Arg Ile His 
        915                 920                 925             


Tyr Asp Gly Gly Ala Gly Thr Asn Thr Val Ser Tyr Ala Ala Leu Gly 
    930                 935                 940                 


Arg Gln Asp Ser Ile Thr Val Ser Ala Asp Gly Glu Arg Phe Asn Val 
945                 950                 955                 960 


Arg Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg Glu Gly Val Ala Thr 
                965                 970                 975     


Gln Thr Thr Ala Tyr Gly Lys Arg Thr Glu Asn Val Gln Tyr Arg His 
            980                 985                 990         


Val Glu Leu Ala Arg Val Gly Gln  Leu Val Glu Val Asp  Thr Leu Glu 
        995                 1000                 1005             


His Val  Gln His Ile Ile Gly  Gly Ala Gly Asn Asp  Ser Ile Thr 
    1010                 1015                 1020             


Gly Asn  Ala His Asp Asn Phe  Leu Ala Gly Gly Ser  Gly Asp Asp 
    1025                 1030                 1035             


Arg Leu  Asp Gly Gly Ala Gly  Asn Asp Thr Leu Val  Gly Gly Glu 
    1040                 1045                 1050             


Gly Gln  Asn Thr Val Ile Gly  Gly Ala Gly Asp Asp  Val Phe Leu 
    1055                 1060                 1065             


Gln Asp  Leu Gly Val Trp Ser  Asn Gln Leu Asp Gly  Gly Ala Gly 
    1070                 1075                 1080             


Val Asp  Thr Val Lys Tyr Asn  Val His Gln Pro Ser  Glu Glu Arg 
    1085                 1090                 1095             


Leu Glu  Arg Met Gly Asp Thr  Gly Ile His Ala Asp  Leu Gln Lys 
    1100                 1105                 1110             


Gly Thr  Val Glu Lys Trp Pro  Ala Leu Asn Leu Phe  Ser Val Asp 
    1115                 1120                 1125             


His Val  Lys Asn Ile Glu Asn  Leu His Gly Ser Arg  Leu Asn Asp 
    1130                 1135                 1140             


Arg Ile  Ala Gly Asp Asp Gln  Asp Asn Glu Leu Trp  Gly His Asp 
    1145                 1150                 1155             


Gly Asn  Asp Thr Ile Arg Gly  Arg Gly Gly Asp Asp  Ile Leu Arg 
    1160                 1165                 1170             


Gly Gly  Leu Gly Leu Asp Thr  Leu Tyr Gly Glu Asp  Gly Asn Asp 
    1175                 1180                 1185             


Ile Phe  Leu Gln Asp Asp Glu  Thr Val Ser Asp Asp  Ile Asp Gly 
    1190                 1195                 1200             


Gly Ala  Gly Leu Asp Thr Val  Asp Tyr Ser Ala Met  Ile His Pro 
    1205                 1210                 1215             


Gly Arg  Ile Val Ala Pro His  Glu Tyr Gly Phe Gly  Ile Glu Ala 
    1220                 1225                 1230             


Asp Leu  Ser Arg Glu Trp Val  Arg Lys Ala Ser Ala  Leu Gly Val 
    1235                 1240                 1245             


Asp Tyr  Tyr Asp Asn Val Arg  Asn Val Glu Asn Val  Ile Gly Thr 
    1250                 1255                 1260             


Ser Met  Lys Asp Val Leu Ile  Gly Asp Ala Gln Ala  Asn Thr Leu 
    1265                 1270                 1275             


Met Gly  Gln Gly Gly Asp Asp  Thr Val Arg Gly Gly  Asp Gly Asp 
    1280                 1285                 1290             


Asp Leu  Leu Phe Gly Gly Asp  Gly Asn Asp Met Leu  Tyr Gly Asp 
    1295                 1300                 1305             


Ala Gly  Asn Asp Thr Leu Tyr  Gly Gly Leu Gly Asp  Asp Thr Leu 
    1310                 1315                 1320             


Glu Gly  Gly Ala Gly Asn Asp  Trp Phe Gly Gln Thr  Gln Ala Arg 
    1325                 1330                 1335             


Glu His  Asp Val Leu Arg Gly  Gly Asp Gly Val Asp  Thr Val Asp 
    1340                 1345                 1350             


Tyr Ser  Gln Thr Gly Ala His  Ala Gly Ile Ala Ala  Gly Arg Ile 
    1355                 1360                 1365             


Gly Leu  Gly Ile Leu Ala Asp  Leu Gly Ala Gly Arg  Val Asp Lys 
    1370                 1375                 1380             


Leu Gly  Glu Ala Gly Ser Ser  Ala Tyr Asp Thr Val  Ser Gly Ile 
    1385                 1390                 1395             


Glu Asn  Val Val Gly Thr Glu  Leu Ala Asp Arg Ile  Thr Gly Asp 
    1400                 1405                 1410             


Ala Gln  Ala Asn Val Leu Arg  Gly Ala Gly Gly Ala  Asp Val Leu 
    1415                 1420                 1425             


Ala Gly  Gly Glu Gly Asp Asp  Val Leu Leu Gly Gly  Asp Gly Asp 
    1430                 1435                 1440             


Asp Gln  Leu Ser Gly Asp Ala  Gly Arg Asp Arg Leu  Tyr Gly Glu 
    1445                 1450                 1455             


Ala Gly  Asp Asp Trp Phe Phe  Gln Asp Ala Ala Asn  Ala Gly Asn 
    1460                 1465                 1470             


Leu Leu  Asp Gly Gly Asp Gly  Arg Asp Thr Val Asp  Phe Ser Gly 
    1475                 1480                 1485             


Pro Gly  Arg Gly Leu Asp Ala  Gly Ala Lys Gly Val  Phe Leu Ser 
    1490                 1495                 1500             


Leu Gly  Lys Gly Phe Ala Ser  Leu Met Asp Glu Pro  Glu Thr Ser 
    1505                 1510                 1515             


Asn Val  Leu Arg Asn Ile Glu  Asn Ala Val Gly Ser  Ala Arg Asp 
    1520                 1525                 1530             


Asp Val  Leu Ile Gly Asp Ala  Gly Ala Asn Val Leu  Asn Gly Leu 
    1535                 1540                 1545             


Ala Gly  Asn Asp Val Leu Ser  Gly Gly Ala Gly Asp  Asp Val Leu 
    1550                 1555                 1560             


Leu Gly  Asp Glu Gly Ser Asp  Leu Leu Ser Gly Asp  Ala Gly Asn 
    1565                 1570                 1575             


Asp Asp  Leu Phe Gly Gly Gln  Gly Asp Asp Thr Tyr  Leu Phe Gly 
    1580                 1585                 1590             


Val Gly  Tyr Gly His Asp Thr  Ile Tyr Glu Ser Gly  Gly Gly His 
    1595                 1600                 1605             


Asp Thr  Ile Arg Ile Asn Ala  Gly Ala Asp Gln Leu  Trp Phe Ala 
    1610                 1615                 1620             


Arg Gln  Gly Asn Asp Leu Glu  Ile Arg Ile Leu Gly  Thr Asp Asp 
    1625                 1630                 1635             


Ala Leu  Thr Val His Asp Trp  Tyr Arg Asp Ala Asp  His Arg Val 
    1640                 1645                 1650             


Glu Ile  Ile His Ala Ala Asn  Gln Ala Val Asp Gln  Ala Gly Ile 
    1655                 1660                 1665             


Glu Lys  Leu Val Glu Ala Met  Ala Gln Tyr Pro Asp  Pro Gly Ala 
    1670                 1675                 1680             


Ala Ala  Ala Ala Pro Pro Ala  Ala Arg Val Pro Asp  Thr Leu Met 
    1685                 1690                 1695             


Gln Ser  Leu Ala Val Asn Trp  Arg 
    1700                 1705     


<210>  65
<211>  5131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimised CyAA

<400>  65
catatgcagc agtcccatca ggccggttac gcaaacgcag ccgatcgtga atctggtatc       60

ccggcagcgg ttctggatgg tattaaggca gttgccaaag agaagaacgc taccctgatg      120

ttccgtctgg tcaacccaca ctctacttcc ctgatcgcgg aaggtgtggc gaccaaaggc      180

ctgggtgtgc acgccaaaag cagcgactgg ggtctgcagg caggttatat tccggtgaac      240

ccgaatctgt ctaaactgtt cggtcgtgcc ccggaggtga tcgcacgtgc agacaacgat      300

gtcaactctt ctctggcgca tggtcacacc gcggttgatc tgaccctgtc caaagaacgc      360

ctggattacc tgcgtcaggc gggcctggtg acgggcatgg ccgacggtgt tgtagcgagc      420

aaccacgcgg gttatgaaca atttgagttt cgcgttaaag agacctctga cggtcgttac      480

gcggtgcagt accgccgcaa aggtggcgat gactttgaag ctgtcaaagt gatcggtaac      540

gctgctggaa ttccgctgac cgcggatatc gacatgtttg ccatcatgcc tcacctgtcc      600

aactttcgcg attccgcacg cagctctgtg acgtctggtg attccgtcac tgactacctg      660

gctcgtaccc gtcgtgcggc ctctgaagcc actggtggtc tggatcgtga acgcattgac      720

ctgctgtgga aaatcgcccg tgccggtgcg cgctctgctg ttggtaccga agcacgccgc      780

caatttcgtt acgacggcga tatgaacatc ggtgtgatca cggattttga actggaagtt      840

cgcaatgccc tgaaccgtcg tgcacacgcg gtcggcgcgc aggacgttgt tcagcacggt      900

acggagcaga ataacccgtt cccagaagcg gacgaaaaga tctttgttgt gtctgccacc      960

ggtgaatccc agatgctgac tcgtggccag ctgaaagaat acatcggcca acagcgtggc     1020

gaaggctacg ttttctacga gaatcgtgct tacggcgttg cgggcaaatc cctgttcgac     1080

gatggtctgg gcgctgcacc gggcgttccg agcggccgtt ctaaattcag cccggacgta     1140

ctggaaactg tgccggcttc cccgggcctg cgccgtccgt ccctgggcgc agtcgaacgt     1200

caggactccg gctacgattc cctggatggc gttggctccc gctccttctc cctgggcgag     1260

gtttctgaca tggctgcggt ggaagcggca gagctggaaa tgacccgtca agtgctgcac     1320

gcgggcgcac gtcaggacga tgctgagccg ggcgtgtccg gtgcgtctgc acactggggt     1380

caacgtgccc tgcagggtgc tcaagctgtc gcggcagcgc agcgtctggt acatgcgatc     1440

gcactgatga cccagttcgg tcgcgcaggt tctaccaaca ctcctcagga agcagctagc     1500

ctgtctgctg ctgttttcgg tctgggcgaa gcgtcttctg cggttgcaga aaccgtgagc     1560

ggtttcttcc gtggttctag ccgctgggcg ggtggttttg gtgtagcagg tggcgctatg     1620

gccctgggtg gcggtatcgc ggctgctgtc ggcgcaggta tgagcctgac cgacgatgct     1680

cctgcgggcc agaaagccgc agctggcgct gaaatcgcgc tgcagctgac tggtggtacc     1740

gttgaactgg ctagctctat cgcgctggct ctggcagcgg cacgtggcgt gacttctggc     1800

ctgcaagtcg ccggtgcctc tgcgggcgct gctgcgggcg ctctggcagc tgcactgtcc     1860

cccatggaaa tctacggtct ggtacagcag tctcactacg cagaccagct ggataaactg     1920

gcgcaggagt cttctgcata cggttacgaa ggcgacgcac tgctggcgca gctgtatcgt     1980

gacaaaactg ctgctgaagg tgctgtggca ggcgtttctg cggtactgtc taccgttggc     2040

gctgcggttt ctattgcggc tgccgcatcc gttgtaggtg cgccggttgc tgtagttacc     2100

tctctgctga ctggtgcact gaacggtatc ctgcgtggtg ttcagcagcc tattatcgaa     2160

aaactggcga atgattatgc ccgtaaaatc gacgaactgg gcggtccgca ggcttatttt     2220

gaaaaaaacc tgcaggcgcg ccacgaacag ctggcaaaca gcgacggcct gcgcaaaatg     2280

ctggcagacc tgcaagctgg ttggaacgcg tcttctgtga tcggcgtgca gaccaccgaa     2340

attagcaaat ctgcgctgga actggctgca attactggca acgcggataa cctgaaaagc     2400

gttgatgttt ttgtcgatcg cttcgttcag ggcgagcgcg ttgctggtca gccggttgtt     2460

ctggacgttg cggcaggcgg catcgacatc gctagccgca agggcgagcg tccggctctg     2520

actttcatta ccccgctggc agctccgggt gaagaacagc gtcgccgtac caagactggt     2580

aaaagcgagt tcaccacctt cgtggaaatc gtaggtaaac aggaccgctg gcgtattcgc     2640

gacggtgcgg cggacaccac catcgacctg gcaaaagttg tttcccaact ggtagatgct     2700

aacggcgtgc tgaaacattc tattaaactg gatgtaatcg gcggtgacgg cgatgacgtt     2760

gtactggcga acgcgtctcg tatccactat gacggcggcg caggtaccaa cacggtttcc     2820

tacgcagcgc tgggccgcca ggattccatc actgttagcg ccgatggcga acgtttcaac     2880

gtgcgtaaac agctgaataa cgcaaacgtc tatcgtgagg gtgtagctac ccagaccacc     2940

gcgtacggta agcgtaccga aaacgttcag tatcgtcacg tggaactggc acgtgtgggt     3000

cagctggtag aggtggatac gctggaacac gtgcagcaca tcatcggtgg cgccggtaac     3060

gattccatta ctggtaacgc tcacgacaac ttcctggcag gtggttctgg tgatgatcgt     3120

ctggacggtg gtgcgggtaa cgatacgctg gtaggcggcg aaggtcagaa caccgtaatt     3180

ggtggtgccg gtgacgacgt tttcctgcag gatctgggcg tttggagcaa ccagctggat     3240

ggcggtgccg gtgttgacac ggttaagtat aacgttcacc agccgtctga agagcgcctg     3300

gaacgtatgg gtgacactgg tattcatgcc gatctgcaga aaggcactgt tgaaaaatgg     3360

cctgcgctga acctgttctc tgtggaccat gttaagaaca ttgaaaacct gcatggctct     3420

cgcctgaacg accgtatcgc tggtgacgac caggataacg aactgtgggg tcatgacggc     3480

aatgatacca ttcgcggtcg tggcggcgac gatattctgc gtggcggtct gggcctggat     3540

accctgtatg gtgaagatgg taacgatatt ttcctgcaag acgatgaaac ggtatctgat     3600

gacatcgacg gtggtgcagg cctggacacc gtagattaca gcgctatgat ccatccgggt     3660

cgtatcgtag ctccgcacga gtacggcttc ggtatcgagg cggacctgtc tcgtgaatgg     3720

gttcgtaaag cgtccgcgct gggtgtggac tactacgata acgttcgtaa cgtggaaaac     3780

gtgatcggta cctccatgaa agacgtgctg attggcgacg cacaggccaa cactctgatg     3840

ggccagggcg gtgatgacac ggttcgcggc ggcgacggtg atgacctgct gttcggtggt     3900

gacggcaacg acatgctgta cggcgacgcg ggcaacgaca ccctgtacgg cggtctgggt     3960

gacgacactc tggaaggtgg tgcaggtaac gactggttcg gccaaaccca ggcacgcgaa     4020

cacgacgtgc tgcgtggtgg cgacggcgta gacaccgtgg attactccca aactggcgct     4080

cacgcgggta tcgcggccgg tcgtatcggt ctgggcattc tggccgatct gggtgccggc     4140

cgtgtcgaca aactgggtga ggctggctct agcgcctatg atactgtttc cggcatcgaa     4200

aacgtggtag gcactgaact ggcagatcgt atcacgggtg acgcgcaagc gaacgttctg     4260

cgtggtgctg gcggtgcaga cgtgctggcg ggtggtgaag gcgacgacgt actgctgggc     4320

ggtgacggtg acgatcagct gagcggtgat gcgggtcgtg accgtctgta cggtgaagca     4380

ggtgacgatt ggttcttcca ggacgctgct aacgctggca acctgctgga cggcggcgat     4440

ggccgtgaca ctgttgactt cagcggtccg ggtcgcggtc tggacgcagg cgcgaaaggc     4500

gttttcctga gcctgggtaa gggtttcgca tctctgatgg acgaaccaga aaccagcaat     4560

gtcctgcgta acatcgaaaa cgctgtcggt tccgcacgcg atgatgttct gattggcgat     4620

gctggtgcca atgttctgaa cggtctggcg ggtaatgatg tactgtctgg tggcgctggt     4680

gatgatgtcc tgctgggtga tgagggcagc gatctgctgt ccggcgatgc cggcaacgac     4740

gatctgttcg gtggccaagg tgatgatact tacctgttcg gcgttggcta tggtcatgac     4800

accatctatg agtctggtgg cggccacgat acgattcgta ttaatgcagg tgctgaccaa     4860

ctgtggtttg cacgtcaggg taacgatctg gaaattcgca tcctgggtac tgatgacgct     4920

ctgaccgtac acgactggta ccgcgatgcg gatcaccgcg tagaaatcat ccatgcggct     4980

aaccaagctg tagaccaggc tggtattgaa aaactggtag aagcgatggc acagtatccg     5040

gacccaggtg cggctgctgc agcacctcca gcggctcgtg tgccggatac cctgatgcag     5100

agcctggccg tcaattggcg ttaatggatc c                                    5131


<210>  66
<211>  5382
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E7-CyaA HPV16


<220>
<221>  CDS
<222>  (1)..(5382)

<220>
<221>  misc_feature
<222>  (685)..(850)
<223>  E7 protein fragment

<220>
<221>  misc_feature
<222>  (1123)..(1207)
<223>  E7 protein fragment

<400>  66
atg cag caa tcg cat cag gct ggt tac gca aac gcc gcc gac cgg gag         48
Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu           
1               5                   10                  15                

tct ggc atc ccc gca gcc gta ctc gat ggc atc aag gcc gtg gcg aag         96
Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys           
            20                  25                  30                    

gaa aaa aac gcc aca ttg atg ttc cgc ctg gtc aac ccc cat tcc acc        144
Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr           
        35                  40                  45                        

agc ctg att gcc gaa ggg gtg gcc acc aaa gga ttg ggc gtg cac gcc        192
Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala           
    50                  55                  60                            

aag tcg tcc gat tgg ggg ttg cag gcg ggc tac att ccc gtc aac ccg        240
Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro           
65                  70                  75                  80            

aat ctt tcc aaa ctg ttc ggc cgt gcg ccc gag gtg atc gcg cgg gcc        288
Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala           
                85                  90                  95                

gac aac gac gtc aac agc agc ctg gcg cat ggc cat acc gcg gtc gac        336
Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp           
            100                 105                 110                   

ctg acg ctg tcg aaa gag cgg ctt gac tat ctg cgg caa gcg ggc ctg        384
Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu           
        115                 120                 125                       

gtc acc ggc atg gcc gat ggc gtg gtc gcg agc aac cac gca ggc tac        432
Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr           
    130                 135                 140                           

gag cag ttc gag ttt cgc gtg aag gaa acc tcg gac ggg cgc tat gcc        480
Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala           
145                 150                 155                 160           

gtg cag tat cgc cgc aag ggc ggc gac gat ttc gag gcg gtc aag gtg        528
Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val           
                165                 170                 175               

atc ggc aat gcc gcc ggt att cca ctg acg gcg gat ctg cag atc gac        576
Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Leu Gln Ile Asp           
            180                 185                 190                   

atg ttc gcc att atg ccg cat ctg tcc aac ttc cgc gac tcg gcg cgc        624
Met Phe Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg           
        195                 200                 205                       

agt tcg gtg acc agc ggc gat tcg gtg acc gat tac ctg gcg cgt acg        672
Ser Ser Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr           
    210                 215                 220                           

cgt cgt gct agc ggt caa gca gaa ccg gac aga gcc cac tat aat atc        720
Arg Arg Ala Ser Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile           
225                 230                 235                 240           

gtc aca ttt tgc tgt aaa tgc gac tca act ctc cgt ttg tgt gta cag        768
Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln           
                245                 250                 255               

agc acc cat gtg gac atc cgc acc ctg gag gat tta ctg atg ggt act        816
Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr           
            260                 265                 270                   

ctg ggg att gtt tgt ccg att tgc tct caa aaa cct ggt acc cgc gca        864
Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys Pro Gly Thr Arg Ala           
        275                 280                 285                       

cgc ctt aag ttg ttg tgg aaa atc gct cgc gcc ggc gcc cgt tcc gca        912
Arg Leu Lys Leu Leu Trp Lys Ile Ala Arg Ala Gly Ala Arg Ser Ala           
    290                 295                 300                           

gtg ggc acc gag gcg cgt cgc cag ttc cgc tac gac ggc gac atg aat        960
Val Gly Thr Glu Ala Arg Arg Gln Phe Arg Tyr Asp Gly Asp Met Asn           
305                 310                 315                 320           

atc ggc gtg atc acc gat ttc gag ctg gaa gtg cgc aat gcg ctg aac       1008
Ile Gly Val Ile Thr Asp Phe Glu Leu Glu Val Arg Asn Ala Leu Asn           
                325                 330                 335               

agg cgg gcg cac gcc gtc ggc gcg cag gac gtg gtc cag cat ggc act       1056
Arg Arg Ala His Ala Val Gly Ala Gln Asp Val Val Gln His Gly Thr           
            340                 345                 350                   

gag cag aac aat cct ttc ccg gag gca gat gag aag att ttc gtc gta       1104
Glu Gln Asn Asn Pro Phe Pro Glu Ala Asp Glu Lys Ile Phe Val Val           
        355                 360                 365                       

tcg gcc acc ggt aaa cgt atg cac ggc gat act ccg acg ctt cat gaa       1152
Ser Ala Thr Gly Lys Arg Met His Gly Asp Thr Pro Thr Leu His Glu           
    370                 375                 380                           

tac atg ttg gat ctg cag cca gaa acg acc gac tta tat tgc tac gag       1200
Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu           
385                 390                 395                 400           

cag ctg aac aaa cgt act agt gaa agc cag atg ctc acg cgc ggg caa       1248
Gln Leu Asn Lys Arg Thr Ser Glu Ser Gln Met Leu Thr Arg Gly Gln           
                405                 410                 415               

ctg aag gaa tac att ggc cag cag cgc ggc gag ggc tat gtc ttc tac       1296
Leu Lys Glu Tyr Ile Gly Gln Gln Arg Gly Glu Gly Tyr Val Phe Tyr           
            420                 425                 430                   

gag aac cgt gca tac ggc gtg gcg ggg aaa agc ctg ttc gac gat ggg       1344
Glu Asn Arg Ala Tyr Gly Val Ala Gly Lys Ser Leu Phe Asp Asp Gly           
        435                 440                 445                       

ctg gga gcc gcg ccc ggc gtg ccg agc gga cgt tcg aag ttc tcg ccg       1392
Leu Gly Ala Ala Pro Gly Val Pro Ser Gly Arg Ser Lys Phe Ser Pro           
    450                 455                 460                           

gat gta ctg gaa acg gtg ccg gcg tca ccc gga ttg cgg cgg ccg tcg       1440
Asp Val Leu Glu Thr Val Pro Ala Ser Pro Gly Leu Arg Arg Pro Ser           
465                 470                 475                 480           

ctg ggc gca gtg gaa cgc cag gat tcc ggc tat gac agc ctt gat ggg       1488
Leu Gly Ala Val Glu Arg Gln Asp Ser Gly Tyr Asp Ser Leu Asp Gly           
                485                 490                 495               

gtg gga tcg cga tcg ttc tcg ttg ggc gag gtg tcc gac atg gcc gcc       1536
Val Gly Ser Arg Ser Phe Ser Leu Gly Glu Val Ser Asp Met Ala Ala           
            500                 505                 510                   

gtg gaa gcg gcg gaa ctg gaa atg acc cgg caa gtc ttg cac gcc ggg       1584
Val Glu Ala Ala Glu Leu Glu Met Thr Arg Gln Val Leu His Ala Gly           
        515                 520                 525                       

gcg cgg cag gac gat gcc gag ccg ggc gtg agc ggt gcg tcg gcg cac       1632
Ala Arg Gln Asp Asp Ala Glu Pro Gly Val Ser Gly Ala Ser Ala His           
    530                 535                 540                           

tgg ggg cag cgg gcg ctg cag ggc gcc cag gcg gtg gcg gcg gcg cag       1680
Trp Gly Gln Arg Ala Leu Gln Gly Ala Gln Ala Val Ala Ala Ala Gln           
545                 550                 555                 560           

cgg ctg gtt cat gcc att gcc ctg atg acg caa ttc ggc cgg gcc ggt       1728
Arg Leu Val His Ala Ile Ala Leu Met Thr Gln Phe Gly Arg Ala Gly           
                565                 570                 575               

tcc acc aac acg ccg cag gaa gcg gcc tcg ttg tcg gcg gcc gtg ttc       1776
Ser Thr Asn Thr Pro Gln Glu Ala Ala Ser Leu Ser Ala Ala Val Phe           
            580                 585                 590                   

ggc ttg ggc gag gcc agc agc gcc gtg gcc gaa acc gtg agc ggt ttt       1824
Gly Leu Gly Glu Ala Ser Ser Ala Val Ala Glu Thr Val Ser Gly Phe           
        595                 600                 605                       

ttc cgc ggg tct tcg cgc tgg gcc ggc ggt ttc ggc gtg gct ggc ggc       1872
Phe Arg Gly Ser Ser Arg Trp Ala Gly Gly Phe Gly Val Ala Gly Gly           
    610                 615                 620                           

gcg atg gcg ctg gga ggc ggc atc gcc gcg gcc gtt ggc gcc ggg atg       1920
Ala Met Ala Leu Gly Gly Gly Ile Ala Ala Ala Val Gly Ala Gly Met           
625                 630                 635                 640           

tcg ttg acc gat gac gcg ccg gcc gga cag aag gcc gcc gcc ggc gcc       1968
Ser Leu Thr Asp Asp Ala Pro Ala Gly Gln Lys Ala Ala Ala Gly Ala           
                645                 650                 655               

gag atc gcg ctg cag ttg aca ggt gga acg gtc gag ctg gct tct tcc       2016
Glu Ile Ala Leu Gln Leu Thr Gly Gly Thr Val Glu Leu Ala Ser Ser           
            660                 665                 670                   

atc gcg ttg gcg ctg gcc gcg gcg cgc ggc gtg acc agc ggc ttg cag       2064
Ile Ala Leu Ala Leu Ala Ala Ala Arg Gly Val Thr Ser Gly Leu Gln           
        675                 680                 685                       

gtg gcc ggg gcg tcg gcc ggg gcg gct gcc ggc gca ttg gcc gcg gcg       2112
Val Ala Gly Ala Ser Ala Gly Ala Ala Ala Gly Ala Leu Ala Ala Ala           
    690                 695                 700                           

ctc agt ccc atg gag atc tac ggc ctg gtg cag caa tcg cac tat gcg       2160
Leu Ser Pro Met Glu Ile Tyr Gly Leu Val Gln Gln Ser His Tyr Ala           
705                 710                 715                 720           

gat cag ctg gac aag ctg gcg cag gaa tcg agc gca tac ggt tac gag       2208
Asp Gln Leu Asp Lys Leu Ala Gln Glu Ser Ser Ala Tyr Gly Tyr Glu           
                725                 730                 735               

ggc gac gcc ttg ctg gcc cag ctg tat cgc gac aag acg gcc gcc gag       2256
Gly Asp Ala Leu Leu Ala Gln Leu Tyr Arg Asp Lys Thr Ala Ala Glu           
            740                 745                 750                   

ggc gcc gtc gcc ggc gtc tcc gcc gtc ctg agc acg gtg ggg gcg gcg       2304
Gly Ala Val Ala Gly Val Ser Ala Val Leu Ser Thr Val Gly Ala Ala           
        755                 760                 765                       

gtg tcg atc gcc gcg gcg gcc agc gtg gta ggg gcc ccg gtg gcg gtg       2352
Val Ser Ile Ala Ala Ala Ala Ser Val Val Gly Ala Pro Val Ala Val           
    770                 775                 780                           

gtc act tcc ttg ctg acc ggg gct ctc aac ggc atc ctg cgc ggc gtg       2400
Val Thr Ser Leu Leu Thr Gly Ala Leu Asn Gly Ile Leu Arg Gly Val           
785                 790                 795                 800           

cag cag ccc atc atc gaa aag ctg gcc aac gat tac gct cgc aag atc       2448
Gln Gln Pro Ile Ile Glu Lys Leu Ala Asn Asp Tyr Ala Arg Lys Ile           
                805                 810                 815               

gac gag ctg ggc ggg ccg caa gcg tac ttc gag aaa aac ctg cag gcg       2496
Asp Glu Leu Gly Gly Pro Gln Ala Tyr Phe Glu Lys Asn Leu Gln Ala           
            820                 825                 830                   

cgt cac gaa caa ctg gcc aat tcg gac ggc cta cgg aaa atg ctg gcc       2544
Arg His Glu Gln Leu Ala Asn Ser Asp Gly Leu Arg Lys Met Leu Ala           
        835                 840                 845                       

gac ctg cag gcc ggt tgg aac gcc agc agc gtg atc ggg gtg cag acg       2592
Asp Leu Gln Ala Gly Trp Asn Ala Ser Ser Val Ile Gly Val Gln Thr           
    850                 855                 860                           

aca gag atc tcc aag tcg gcg ctc gaa ctg gcc gcc att acc ggc aac       2640
Thr Glu Ile Ser Lys Ser Ala Leu Glu Leu Ala Ala Ile Thr Gly Asn           
865                 870                 875                 880           

gcg gac aac ctg aaa tcc gtc gac gtg ttc gtg gac cgc ttc gtc cag       2688
Ala Asp Asn Leu Lys Ser Val Asp Val Phe Val Asp Arg Phe Val Gln           
                885                 890                 895               

ggc gag cgg gtg gcc ggc cag ccg gtg gtc ctc gac gtc gcc gcc ggc       2736
Gly Glu Arg Val Ala Gly Gln Pro Val Val Leu Asp Val Ala Ala Gly           
            900                 905                 910                   

ggc atc gat atc gcc agc cgc aag ggc gag cgg ccg gcg ctg acg ttc       2784
Gly Ile Asp Ile Ala Ser Arg Lys Gly Glu Arg Pro Ala Leu Thr Phe           
        915                 920                 925                       

atc acg ccg ctg gcc gcg cca gga gaa gag cag cgc cgg cgc acg aaa       2832
Ile Thr Pro Leu Ala Ala Pro Gly Glu Glu Gln Arg Arg Arg Thr Lys           
    930                 935                 940                           

acg ggc aag agc gaa ttc acc aca ttc gtc gag atc gtg ggc aag cag       2880
Thr Gly Lys Ser Glu Phe Thr Thr Phe Val Glu Ile Val Gly Lys Gln           
945                 950                 955                 960           

gac cgc tgg cgc atc cgg gac ggc gcg gcc gac acc acc atc gat ctg       2928
Asp Arg Trp Arg Ile Arg Asp Gly Ala Ala Asp Thr Thr Ile Asp Leu           
                965                 970                 975               

gcc aag gtg gtg tcg caa ctg gtc gac gcc aat ggc gtg ctc aag cac       2976
Ala Lys Val Val Ser Gln Leu Val Asp Ala Asn Gly Val Leu Lys His           
            980                 985                 990                   

agc atc aaa ctg gat gtg atc ggc  gga gat ggc gat gac  gtc gtg ctt     3024
Ser Ile Lys Leu Asp Val Ile Gly  Gly Asp Gly Asp Asp  Val Val Leu         
        995                 1000                 1005                     

gcc aat  gct tcg cgc atc cat  tat gac ggc ggc gcg  ggc acc aac        3069
Ala Asn  Ala Ser Arg Ile His  Tyr Asp Gly Gly Ala  Gly Thr Asn            
    1010                 1015                 1020                        

acg gtc  agc tat gcc gcc ctg  ggt cga cag gat tcc  att acc gtg        3114
Thr Val  Ser Tyr Ala Ala Leu  Gly Arg Gln Asp Ser  Ile Thr Val            
    1025                 1030                 1035                        

tcc gcc  gac ggg gaa cgt ttc  aac gtg cgc aag cag  ttg aac aac        3159
Ser Ala  Asp Gly Glu Arg Phe  Asn Val Arg Lys Gln  Leu Asn Asn            
    1040                 1045                 1050                        

gcc aac  gtg tat cgc gaa ggc  gtg gct acc cag aca  acc gcc tac        3204
Ala Asn  Val Tyr Arg Glu Gly  Val Ala Thr Gln Thr  Thr Ala Tyr            
    1055                 1060                 1065                        

ggc aag  cgc acg gag aat gtc  caa tac cgc cat gtc  gag ctg gcc        3249
Gly Lys  Arg Thr Glu Asn Val  Gln Tyr Arg His Val  Glu Leu Ala            
    1070                 1075                 1080                        

cgt gtc  ggg caa ctg gtg gag  gtc gac acg ctc gag  cat gtg cag        3294
Arg Val  Gly Gln Leu Val Glu  Val Asp Thr Leu Glu  His Val Gln            
    1085                 1090                 1095                        

cac atc  atc ggc ggg gcc ggc  aac gat tcg atc acc  ggc aat gcg        3339
His Ile  Ile Gly Gly Ala Gly  Asn Asp Ser Ile Thr  Gly Asn Ala            
    1100                 1105                 1110                        

cac gac  aac ttc cta gcc ggc  ggg tcg ggc gac gac  agg ctg gat        3384
His Asp  Asn Phe Leu Ala Gly  Gly Ser Gly Asp Asp  Arg Leu Asp            
    1115                 1120                 1125                        

ggc ggc  gcc ggc aac gac acc  ctg gtt ggc ggc gag  ggc caa aac        3429
Gly Gly  Ala Gly Asn Asp Thr  Leu Val Gly Gly Glu  Gly Gln Asn            
    1130                 1135                 1140                        

acg gtc  atc ggc ggc gcc ggc  gac gac gta ttc ctg  cag gac ctg        3474
Thr Val  Ile Gly Gly Ala Gly  Asp Asp Val Phe Leu  Gln Asp Leu            
    1145                 1150                 1155                        

ggg gta  tgg agc aac cag ctc  gat ggc ggc gcg ggc  gtc gat acc        3519
Gly Val  Trp Ser Asn Gln Leu  Asp Gly Gly Ala Gly  Val Asp Thr            
    1160                 1165                 1170                        

gtg aag  tac aac gtg cac cag  cct tcc gag gag cgc  ctc gaa cgc        3564
Val Lys  Tyr Asn Val His Gln  Pro Ser Glu Glu Arg  Leu Glu Arg            
    1175                 1180                 1185                        

atg ggc  gac acg ggc atc cat  gcc gat ctt caa aag  ggc acg gtc        3609
Met Gly  Asp Thr Gly Ile His  Ala Asp Leu Gln Lys  Gly Thr Val            
    1190                 1195                 1200                        

gag aag  tgg ccg gcc ctg aac  ctg ttc agc gtc gac  cat gtc aag        3654
Glu Lys  Trp Pro Ala Leu Asn  Leu Phe Ser Val Asp  His Val Lys            
    1205                 1210                 1215                        

aat atc  gag aat ctg cac ggc  tcc cgc cta aac gac  cgc atc gcc        3699
Asn Ile  Glu Asn Leu His Gly  Ser Arg Leu Asn Asp  Arg Ile Ala            
    1220                 1225                 1230                        

ggc gac  gac cag gac aac gag  ctc tgg ggc cac gat  ggc aac gac        3744
Gly Asp  Asp Gln Asp Asn Glu  Leu Trp Gly His Asp  Gly Asn Asp            
    1235                 1240                 1245                        

acg ata  cgc ggc cgg ggc ggc  gac gac atc ctg cgc  ggc ggc ctg        3789
Thr Ile  Arg Gly Arg Gly Gly  Asp Asp Ile Leu Arg  Gly Gly Leu            
    1250                 1255                 1260                        

ggc ctg  gac acg ctg tat ggc  gag gac ggc aac gac  atc ttc ctg        3834
Gly Leu  Asp Thr Leu Tyr Gly  Glu Asp Gly Asn Asp  Ile Phe Leu            
    1265                 1270                 1275                        

cag gac  gac gag acc gtc agc  gat gac atc gac ggc  ggc gcg ggg        3879
Gln Asp  Asp Glu Thr Val Ser  Asp Asp Ile Asp Gly  Gly Ala Gly            
    1280                 1285                 1290                        

ctg gac  acc gtc gac tac tcc  gcc atg atc cat cca  ggc agg atc        3924
Leu Asp  Thr Val Asp Tyr Ser  Ala Met Ile His Pro  Gly Arg Ile            
    1295                 1300                 1305                        

gtt gcg  ccg cat gaa tac ggc  ttc ggg atc gag gcg  gac ctg tcc        3969
Val Ala  Pro His Glu Tyr Gly  Phe Gly Ile Glu Ala  Asp Leu Ser            
    1310                 1315                 1320                        

agg gaa  tgg gtg cgc aag gcg  tcc gcg ctg ggc gtg  gac tat tac        4014
Arg Glu  Trp Val Arg Lys Ala  Ser Ala Leu Gly Val  Asp Tyr Tyr            
    1325                 1330                 1335                        

gat aat  gtc cgc aat gtc gaa  aac gtc atc ggt acg  agc atg aag        4059
Asp Asn  Val Arg Asn Val Glu  Asn Val Ile Gly Thr  Ser Met Lys            
    1340                 1345                 1350                        

gat gtg  ctc atc ggc gac gcg  caa gcc aat acc ctg  atg ggc cag        4104
Asp Val  Leu Ile Gly Asp Ala  Gln Ala Asn Thr Leu  Met Gly Gln            
    1355                 1360                 1365                        

ggc ggc  gac gat acc gtg cgc  ggc ggc gac ggc gat  gat ctg ctg        4149
Gly Gly  Asp Asp Thr Val Arg  Gly Gly Asp Gly Asp  Asp Leu Leu            
    1370                 1375                 1380                        

ttc ggc  ggc gac ggc aac gac  atg ctg tat ggc gac  gcc ggc aac        4194
Phe Gly  Gly Asp Gly Asn Asp  Met Leu Tyr Gly Asp  Ala Gly Asn            
    1385                 1390                 1395                        

gac acc  ctc tac ggg ggg ctg  ggc gac gat acc ctt  gaa ggc ggc        4239
Asp Thr  Leu Tyr Gly Gly Leu  Gly Asp Asp Thr Leu  Glu Gly Gly            
    1400                 1405                 1410                        

gcg ggc  aac gat tgg ttc ggc  cag acg cag gcg cgc  gag cat gac        4284
Ala Gly  Asn Asp Trp Phe Gly  Gln Thr Gln Ala Arg  Glu His Asp            
    1415                 1420                 1425                        

gtg ctg  cgc ggc gga gat ggg  gtg gat acc gtc gat  tac agc cag        4329
Val Leu  Arg Gly Gly Asp Gly  Val Asp Thr Val Asp  Tyr Ser Gln            
    1430                 1435                 1440                        

acc ggc  gcg cat gcc ggc att  gcc gcg ggt cgc atc  ggg ctg ggc        4374
Thr Gly  Ala His Ala Gly Ile  Ala Ala Gly Arg Ile  Gly Leu Gly            
    1445                 1450                 1455                        

atc ctg  gct gac ctg ggc gcc  ggc cgc gtc gac aag  ctg ggc gag        4419
Ile Leu  Ala Asp Leu Gly Ala  Gly Arg Val Asp Lys  Leu Gly Glu            
    1460                 1465                 1470                        

gcc ggc  agc agc gcc tac gat  acg gtt tcc ggt atc  gag aac gtg        4464
Ala Gly  Ser Ser Ala Tyr Asp  Thr Val Ser Gly Ile  Glu Asn Val            
    1475                 1480                 1485                        

gtg ggc  acg gaa ctg gcc gac  cgc atc acg ggc gat  gcg cag gcc        4509
Val Gly  Thr Glu Leu Ala Asp  Arg Ile Thr Gly Asp  Ala Gln Ala            
    1490                 1495                 1500                        

aac gtg  ctg cgc ggc gcg ggt  ggc gcc gac gtg ctt  gcg ggc ggc        4554
Asn Val  Leu Arg Gly Ala Gly  Gly Ala Asp Val Leu  Ala Gly Gly            
    1505                 1510                 1515                        

gag ggc  gac gat gtg ctg ctg  ggc ggc gac ggc gac  gac cag ctg        4599
Glu Gly  Asp Asp Val Leu Leu  Gly Gly Asp Gly Asp  Asp Gln Leu            
    1520                 1525                 1530                        

tcg ggc  gac gcc gga cgc gat  cgc ttg tac ggc gaa  gcc ggt gac        4644
Ser Gly  Asp Ala Gly Arg Asp  Arg Leu Tyr Gly Glu  Ala Gly Asp            
    1535                 1540                 1545                        

gac tgg  ttc ttc cag gat gcc  gcc aat gcc ggc aat  ctg ctc gac        4689
Asp Trp  Phe Phe Gln Asp Ala  Ala Asn Ala Gly Asn  Leu Leu Asp            
    1550                 1555                 1560                        

ggc ggc  gac ggc cgc gat acc  gtg gat ttc agc ggc  ccg ggc cgg        4734
Gly Gly  Asp Gly Arg Asp Thr  Val Asp Phe Ser Gly  Pro Gly Arg            
    1565                 1570                 1575                        

ggc ctc  gac gcc ggc gca aag  ggc gta ttc ctg agc  ttg ggc aag        4779
Gly Leu  Asp Ala Gly Ala Lys  Gly Val Phe Leu Ser  Leu Gly Lys            
    1580                 1585                 1590                        

ggg ttc  gcc agc ctg atg gac  gaa ccc gaa acc agc  aac gtg ttg        4824
Gly Phe  Ala Ser Leu Met Asp  Glu Pro Glu Thr Ser  Asn Val Leu            
    1595                 1600                 1605                        

cgc aat  atc gag aac gcc gtg  ggc agc gcg cgt gat  gac gtg ctg        4869
Arg Asn  Ile Glu Asn Ala Val  Gly Ser Ala Arg Asp  Asp Val Leu            
    1610                 1615                 1620                        

atc ggc  gac gca ggc gcc aac  gtc ctc aat ggc ctg  gcg ggc aac        4914
Ile Gly  Asp Ala Gly Ala Asn  Val Leu Asn Gly Leu  Ala Gly Asn            
    1625                 1630                 1635                        

gac gtg  ctg tcc ggc ggc gct  ggc gac gat gtg ctg  ctg ggc gac        4959
Asp Val  Leu Ser Gly Gly Ala  Gly Asp Asp Val Leu  Leu Gly Asp            
    1640                 1645                 1650                        

gag ggc  tcg gac ctg ctc agc  ggc gat gcg ggc aac  gac gat ctg        5004
Glu Gly  Ser Asp Leu Leu Ser  Gly Asp Ala Gly Asn  Asp Asp Leu            
    1655                 1660                 1665                        

ttc ggc  ggg cag ggc gat gat  act tat ctg ttc ggg  gtc ggg tac        5049
Phe Gly  Gly Gln Gly Asp Asp  Thr Tyr Leu Phe Gly  Val Gly Tyr            
    1670                 1675                 1680                        

ggg cac  gac acg atc tac gaa  tcg ggc ggc ggc cat  gac acc atc        5094
Gly His  Asp Thr Ile Tyr Glu  Ser Gly Gly Gly His  Asp Thr Ile            
    1685                 1690                 1695                        

cgc atc  aac gcg ggg gcg gac  cag ctg tgg ttc gcg  cgc cag ggc        5139
Arg Ile  Asn Ala Gly Ala Asp  Gln Leu Trp Phe Ala  Arg Gln Gly            
    1700                 1705                 1710                        

aac gac  ctg gag atc cgc att  ctc ggc acc gac gat  gca ctt acc        5184
Asn Asp  Leu Glu Ile Arg Ile  Leu Gly Thr Asp Asp  Ala Leu Thr            
    1715                 1720                 1725                        

gtg cac  gac tgg tat cgc gac  gcc gat cac cgg gtg  gaa atc atc        5229
Val His  Asp Trp Tyr Arg Asp  Ala Asp His Arg Val  Glu Ile Ile            
    1730                 1735                 1740                        

cat gcc  gcc aac cag gcg gta  gac cag gca ggc atc  gaa aag ctg        5274
His Ala  Ala Asn Gln Ala Val  Asp Gln Ala Gly Ile  Glu Lys Leu            
    1745                 1750                 1755                        

gtc gag  gca atg gcg cag tat  ccg gac ccc ggc gcg  gcg gcg gct        5319
Val Glu  Ala Met Ala Gln Tyr  Pro Asp Pro Gly Ala  Ala Ala Ala            
    1760                 1765                 1770                        

gcc ccg  ccg gcg gcg cgc gtg  ccg gac acg ctg atg  cag tcc ctg        5364
Ala Pro  Pro Ala Ala Arg Val  Pro Asp Thr Leu Met  Gln Ser Leu            
    1775                 1780                 1785                        

gct gtc  aac tgg cgc tga                                              5382
Ala Val  Asn Trp Arg                                                      
    1790                                                                  


<210>  67
<211>  1793
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  67

Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu 
1               5                   10                  15      


Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys 
            20                  25                  30          


Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr 
        35                  40                  45              


Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala 
    50                  55                  60                  


Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro 
65                  70                  75                  80  


Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala 
                85                  90                  95      


Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp 
            100                 105                 110         


Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu 
        115                 120                 125             


Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr 
    130                 135                 140                 


Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala 
145                 150                 155                 160 


Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val 
                165                 170                 175     


Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Leu Gln Ile Asp 
            180                 185                 190         


Met Phe Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg 
        195                 200                 205             


Ser Ser Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr 
    210                 215                 220                 


Arg Arg Ala Ser Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile 
225                 230                 235                 240 


Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln 
                245                 250                 255     


Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr 
            260                 265                 270         


Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys Pro Gly Thr Arg Ala 
        275                 280                 285             


Arg Leu Lys Leu Leu Trp Lys Ile Ala Arg Ala Gly Ala Arg Ser Ala 
    290                 295                 300                 


Val Gly Thr Glu Ala Arg Arg Gln Phe Arg Tyr Asp Gly Asp Met Asn 
305                 310                 315                 320 


Ile Gly Val Ile Thr Asp Phe Glu Leu Glu Val Arg Asn Ala Leu Asn 
                325                 330                 335     


Arg Arg Ala His Ala Val Gly Ala Gln Asp Val Val Gln His Gly Thr 
            340                 345                 350         


Glu Gln Asn Asn Pro Phe Pro Glu Ala Asp Glu Lys Ile Phe Val Val 
        355                 360                 365             


Ser Ala Thr Gly Lys Arg Met His Gly Asp Thr Pro Thr Leu His Glu 
    370                 375                 380                 


Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu 
385                 390                 395                 400 


Gln Leu Asn Lys Arg Thr Ser Glu Ser Gln Met Leu Thr Arg Gly Gln 
                405                 410                 415     


Leu Lys Glu Tyr Ile Gly Gln Gln Arg Gly Glu Gly Tyr Val Phe Tyr 
            420                 425                 430         


Glu Asn Arg Ala Tyr Gly Val Ala Gly Lys Ser Leu Phe Asp Asp Gly 
        435                 440                 445             


Leu Gly Ala Ala Pro Gly Val Pro Ser Gly Arg Ser Lys Phe Ser Pro 
    450                 455                 460                 


Asp Val Leu Glu Thr Val Pro Ala Ser Pro Gly Leu Arg Arg Pro Ser 
465                 470                 475                 480 


Leu Gly Ala Val Glu Arg Gln Asp Ser Gly Tyr Asp Ser Leu Asp Gly 
                485                 490                 495     


Val Gly Ser Arg Ser Phe Ser Leu Gly Glu Val Ser Asp Met Ala Ala 
            500                 505                 510         


Val Glu Ala Ala Glu Leu Glu Met Thr Arg Gln Val Leu His Ala Gly 
        515                 520                 525             


Ala Arg Gln Asp Asp Ala Glu Pro Gly Val Ser Gly Ala Ser Ala His 
    530                 535                 540                 


Trp Gly Gln Arg Ala Leu Gln Gly Ala Gln Ala Val Ala Ala Ala Gln 
545                 550                 555                 560 


Arg Leu Val His Ala Ile Ala Leu Met Thr Gln Phe Gly Arg Ala Gly 
                565                 570                 575     


Ser Thr Asn Thr Pro Gln Glu Ala Ala Ser Leu Ser Ala Ala Val Phe 
            580                 585                 590         


Gly Leu Gly Glu Ala Ser Ser Ala Val Ala Glu Thr Val Ser Gly Phe 
        595                 600                 605             


Phe Arg Gly Ser Ser Arg Trp Ala Gly Gly Phe Gly Val Ala Gly Gly 
    610                 615                 620                 


Ala Met Ala Leu Gly Gly Gly Ile Ala Ala Ala Val Gly Ala Gly Met 
625                 630                 635                 640 


Ser Leu Thr Asp Asp Ala Pro Ala Gly Gln Lys Ala Ala Ala Gly Ala 
                645                 650                 655     


Glu Ile Ala Leu Gln Leu Thr Gly Gly Thr Val Glu Leu Ala Ser Ser 
            660                 665                 670         


Ile Ala Leu Ala Leu Ala Ala Ala Arg Gly Val Thr Ser Gly Leu Gln 
        675                 680                 685             


Val Ala Gly Ala Ser Ala Gly Ala Ala Ala Gly Ala Leu Ala Ala Ala 
    690                 695                 700                 


Leu Ser Pro Met Glu Ile Tyr Gly Leu Val Gln Gln Ser His Tyr Ala 
705                 710                 715                 720 


Asp Gln Leu Asp Lys Leu Ala Gln Glu Ser Ser Ala Tyr Gly Tyr Glu 
                725                 730                 735     


Gly Asp Ala Leu Leu Ala Gln Leu Tyr Arg Asp Lys Thr Ala Ala Glu 
            740                 745                 750         


Gly Ala Val Ala Gly Val Ser Ala Val Leu Ser Thr Val Gly Ala Ala 
        755                 760                 765             


Val Ser Ile Ala Ala Ala Ala Ser Val Val Gly Ala Pro Val Ala Val 
    770                 775                 780                 


Val Thr Ser Leu Leu Thr Gly Ala Leu Asn Gly Ile Leu Arg Gly Val 
785                 790                 795                 800 


Gln Gln Pro Ile Ile Glu Lys Leu Ala Asn Asp Tyr Ala Arg Lys Ile 
                805                 810                 815     


Asp Glu Leu Gly Gly Pro Gln Ala Tyr Phe Glu Lys Asn Leu Gln Ala 
            820                 825                 830         


Arg His Glu Gln Leu Ala Asn Ser Asp Gly Leu Arg Lys Met Leu Ala 
        835                 840                 845             


Asp Leu Gln Ala Gly Trp Asn Ala Ser Ser Val Ile Gly Val Gln Thr 
    850                 855                 860                 


Thr Glu Ile Ser Lys Ser Ala Leu Glu Leu Ala Ala Ile Thr Gly Asn 
865                 870                 875                 880 


Ala Asp Asn Leu Lys Ser Val Asp Val Phe Val Asp Arg Phe Val Gln 
                885                 890                 895     


Gly Glu Arg Val Ala Gly Gln Pro Val Val Leu Asp Val Ala Ala Gly 
            900                 905                 910         


Gly Ile Asp Ile Ala Ser Arg Lys Gly Glu Arg Pro Ala Leu Thr Phe 
        915                 920                 925             


Ile Thr Pro Leu Ala Ala Pro Gly Glu Glu Gln Arg Arg Arg Thr Lys 
    930                 935                 940                 


Thr Gly Lys Ser Glu Phe Thr Thr Phe Val Glu Ile Val Gly Lys Gln 
945                 950                 955                 960 


Asp Arg Trp Arg Ile Arg Asp Gly Ala Ala Asp Thr Thr Ile Asp Leu 
                965                 970                 975     


Ala Lys Val Val Ser Gln Leu Val Asp Ala Asn Gly Val Leu Lys His 
            980                 985                 990         


Ser Ile Lys Leu Asp Val Ile Gly  Gly Asp Gly Asp Asp  Val Val Leu 
        995                 1000                 1005             


Ala Asn  Ala Ser Arg Ile His  Tyr Asp Gly Gly Ala  Gly Thr Asn 
    1010                 1015                 1020             


Thr Val  Ser Tyr Ala Ala Leu  Gly Arg Gln Asp Ser  Ile Thr Val 
    1025                 1030                 1035             


Ser Ala  Asp Gly Glu Arg Phe  Asn Val Arg Lys Gln  Leu Asn Asn 
    1040                 1045                 1050             


Ala Asn  Val Tyr Arg Glu Gly  Val Ala Thr Gln Thr  Thr Ala Tyr 
    1055                 1060                 1065             


Gly Lys  Arg Thr Glu Asn Val  Gln Tyr Arg His Val  Glu Leu Ala 
    1070                 1075                 1080             


Arg Val  Gly Gln Leu Val Glu  Val Asp Thr Leu Glu  His Val Gln 
    1085                 1090                 1095             


His Ile  Ile Gly Gly Ala Gly  Asn Asp Ser Ile Thr  Gly Asn Ala 
    1100                 1105                 1110             


His Asp  Asn Phe Leu Ala Gly  Gly Ser Gly Asp Asp  Arg Leu Asp 
    1115                 1120                 1125             


Gly Gly  Ala Gly Asn Asp Thr  Leu Val Gly Gly Glu  Gly Gln Asn 
    1130                 1135                 1140             


Thr Val  Ile Gly Gly Ala Gly  Asp Asp Val Phe Leu  Gln Asp Leu 
    1145                 1150                 1155             


Gly Val  Trp Ser Asn Gln Leu  Asp Gly Gly Ala Gly  Val Asp Thr 
    1160                 1165                 1170             


Val Lys  Tyr Asn Val His Gln  Pro Ser Glu Glu Arg  Leu Glu Arg 
    1175                 1180                 1185             


Met Gly  Asp Thr Gly Ile His  Ala Asp Leu Gln Lys  Gly Thr Val 
    1190                 1195                 1200             


Glu Lys  Trp Pro Ala Leu Asn  Leu Phe Ser Val Asp  His Val Lys 
    1205                 1210                 1215             


Asn Ile  Glu Asn Leu His Gly  Ser Arg Leu Asn Asp  Arg Ile Ala 
    1220                 1225                 1230             


Gly Asp  Asp Gln Asp Asn Glu  Leu Trp Gly His Asp  Gly Asn Asp 
    1235                 1240                 1245             


Thr Ile  Arg Gly Arg Gly Gly  Asp Asp Ile Leu Arg  Gly Gly Leu 
    1250                 1255                 1260             


Gly Leu  Asp Thr Leu Tyr Gly  Glu Asp Gly Asn Asp  Ile Phe Leu 
    1265                 1270                 1275             


Gln Asp  Asp Glu Thr Val Ser  Asp Asp Ile Asp Gly  Gly Ala Gly 
    1280                 1285                 1290             


Leu Asp  Thr Val Asp Tyr Ser  Ala Met Ile His Pro  Gly Arg Ile 
    1295                 1300                 1305             


Val Ala  Pro His Glu Tyr Gly  Phe Gly Ile Glu Ala  Asp Leu Ser 
    1310                 1315                 1320             


Arg Glu  Trp Val Arg Lys Ala  Ser Ala Leu Gly Val  Asp Tyr Tyr 
    1325                 1330                 1335             


Asp Asn  Val Arg Asn Val Glu  Asn Val Ile Gly Thr  Ser Met Lys 
    1340                 1345                 1350             


Asp Val  Leu Ile Gly Asp Ala  Gln Ala Asn Thr Leu  Met Gly Gln 
    1355                 1360                 1365             


Gly Gly  Asp Asp Thr Val Arg  Gly Gly Asp Gly Asp  Asp Leu Leu 
    1370                 1375                 1380             


Phe Gly  Gly Asp Gly Asn Asp  Met Leu Tyr Gly Asp  Ala Gly Asn 
    1385                 1390                 1395             


Asp Thr  Leu Tyr Gly Gly Leu  Gly Asp Asp Thr Leu  Glu Gly Gly 
    1400                 1405                 1410             


Ala Gly  Asn Asp Trp Phe Gly  Gln Thr Gln Ala Arg  Glu His Asp 
    1415                 1420                 1425             


Val Leu  Arg Gly Gly Asp Gly  Val Asp Thr Val Asp  Tyr Ser Gln 
    1430                 1435                 1440             


Thr Gly  Ala His Ala Gly Ile  Ala Ala Gly Arg Ile  Gly Leu Gly 
    1445                 1450                 1455             


Ile Leu  Ala Asp Leu Gly Ala  Gly Arg Val Asp Lys  Leu Gly Glu 
    1460                 1465                 1470             


Ala Gly  Ser Ser Ala Tyr Asp  Thr Val Ser Gly Ile  Glu Asn Val 
    1475                 1480                 1485             


Val Gly  Thr Glu Leu Ala Asp  Arg Ile Thr Gly Asp  Ala Gln Ala 
    1490                 1495                 1500             


Asn Val  Leu Arg Gly Ala Gly  Gly Ala Asp Val Leu  Ala Gly Gly 
    1505                 1510                 1515             


Glu Gly  Asp Asp Val Leu Leu  Gly Gly Asp Gly Asp  Asp Gln Leu 
    1520                 1525                 1530             


Ser Gly  Asp Ala Gly Arg Asp  Arg Leu Tyr Gly Glu  Ala Gly Asp 
    1535                 1540                 1545             


Asp Trp  Phe Phe Gln Asp Ala  Ala Asn Ala Gly Asn  Leu Leu Asp 
    1550                 1555                 1560             


Gly Gly  Asp Gly Arg Asp Thr  Val Asp Phe Ser Gly  Pro Gly Arg 
    1565                 1570                 1575             


Gly Leu  Asp Ala Gly Ala Lys  Gly Val Phe Leu Ser  Leu Gly Lys 
    1580                 1585                 1590             


Gly Phe  Ala Ser Leu Met Asp  Glu Pro Glu Thr Ser  Asn Val Leu 
    1595                 1600                 1605             


Arg Asn  Ile Glu Asn Ala Val  Gly Ser Ala Arg Asp  Asp Val Leu 
    1610                 1615                 1620             


Ile Gly  Asp Ala Gly Ala Asn  Val Leu Asn Gly Leu  Ala Gly Asn 
    1625                 1630                 1635             


Asp Val  Leu Ser Gly Gly Ala  Gly Asp Asp Val Leu  Leu Gly Asp 
    1640                 1645                 1650             


Glu Gly  Ser Asp Leu Leu Ser  Gly Asp Ala Gly Asn  Asp Asp Leu 
    1655                 1660                 1665             


Phe Gly  Gly Gln Gly Asp Asp  Thr Tyr Leu Phe Gly  Val Gly Tyr 
    1670                 1675                 1680             


Gly His  Asp Thr Ile Tyr Glu  Ser Gly Gly Gly His  Asp Thr Ile 
    1685                 1690                 1695             


Arg Ile  Asn Ala Gly Ala Asp  Gln Leu Trp Phe Ala  Arg Gln Gly 
    1700                 1705                 1710             


Asn Asp  Leu Glu Ile Arg Ile  Leu Gly Thr Asp Asp  Ala Leu Thr 
    1715                 1720                 1725             


Val His  Asp Trp Tyr Arg Asp  Ala Asp His Arg Val  Glu Ile Ile 
    1730                 1735                 1740             


His Ala  Ala Asn Gln Ala Val  Asp Gln Ala Gly Ile  Glu Lys Leu 
    1745                 1750                 1755             


Val Glu  Ala Met Ala Gln Tyr  Pro Asp Pro Gly Ala  Ala Ala Ala 
    1760                 1765                 1770             


Ala Pro  Pro Ala Ala Arg Val  Pro Asp Thr Leu Met  Gln Ser Leu 
    1775                 1780                 1785             


Ala Val  Asn Trp Arg 
    1790             


<210>  68
<211>  5409
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E7-CyaA HPV18


<220>
<221>  CDS
<222>  (1)..(5409)

<220>
<221>  misc_feature
<222>  (685)..(871)
<223>  E7 protein fragment

<220>
<221>  misc_feature
<222>  (1141)..(1234)
<223>  E7 protein fragment

<400>  68
atg cag caa tcg cat cag gct ggt tac gca aac gcc gcc gac cgg gag         48
Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu           
1               5                   10                  15                

tct ggc atc ccc gca gcc gta ctc gat ggc atc aag gcc gtg gcg aag         96
Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys           
            20                  25                  30                    

gaa aaa aac gcc aca ttg atg ttc cgc ctg gtc aac ccc cat tcc acc        144
Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr           
        35                  40                  45                        

agc ctg att gcc gaa ggg gtg gcc acc aaa gga ttg ggc gtg cac gcc        192
Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala           
    50                  55                  60                            

aag tcg tcc gat tgg ggg ttg cag gcg ggc tac att ccc gtc aac ccg        240
Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro           
65                  70                  75                  80            

aat ctt tcc aaa ctg ttc ggc cgt gcg ccc gag gtg atc gcg cgg gcc        288
Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala           
                85                  90                  95                

gac aac gac gtc aac agc agc ctg gcg cat ggc cat acc gcg gtc gac        336
Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp           
            100                 105                 110                   

ctg acg ctg tcg aaa gag cgg ctt gac tat ctg cgg caa gcg ggc ctg        384
Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu           
        115                 120                 125                       

gtc acc ggc atg gcc gat ggc gtg gtc gcg agc aac cac gca ggc tac        432
Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr           
    130                 135                 140                           

gag cag ttc gag ttt cgc gtg aag gaa acc tcg gac ggg cgc tat gcc        480
Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala           
145                 150                 155                 160           

gtg cag tat cgc cgc aag ggc ggc gac gat ttc gag gcg gtc aag gtg        528
Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val           
                165                 170                 175               

atc ggc aat gcc gcc ggt att cca ctg acg gcg gat ctg cag atc gac        576
Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Leu Gln Ile Asp           
            180                 185                 190                   

atg ttc gcc att atg ccg cat ctg tcc aac ttc cgc gac tcg gcg cgc        624
Met Phe Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg           
        195                 200                 205                       

agt tcg gtg acc agc ggc gat tcg gtg acc gat tac ctg gcg cgt acg        672
Ser Ser Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr           
    210                 215                 220                           

cgt cgt gct agc ggt gtg aat cac caa cat ctg ccg gcg cgc cgt gct        720
Arg Arg Ala Ser Gly Val Asn His Gln His Leu Pro Ala Arg Arg Ala           
225                 230                 235                 240           

gaa ccg cag cgc cat acc atg tta tgt atg tgt tgc aag tgt gag gcg        768
Glu Pro Gln Arg His Thr Met Leu Cys Met Cys Cys Lys Cys Glu Ala           
                245                 250                 255               

cgt atc gag ctg gtc gtt gaa tct agc gct gat gat ctg cgt gcg ttt        816
Arg Ile Glu Leu Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala Phe           
            260                 265                 270                   

caa cag ctg ttc ctg aac act tta tcc ttc gta tgc cca tgg tgc gcc        864
Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe Val Cys Pro Trp Cys Ala           
        275                 280                 285                       

agc cag cag ggt acc cgc gca cgc ctt aag ttg ttg tgg aaa atc gct        912
Ser Gln Gln Gly Thr Arg Ala Arg Leu Lys Leu Leu Trp Lys Ile Ala           
    290                 295                 300                           

cgc gcc ggc gcc cgt tcc gca gtg ggc acc gag gcg cgt cgc cag ttc        960
Arg Ala Gly Ala Arg Ser Ala Val Gly Thr Glu Ala Arg Arg Gln Phe           
305                 310                 315                 320           

cgc tac gac ggc gac atg aat atc ggc gtg atc acc gat ttc gag ctg       1008
Arg Tyr Asp Gly Asp Met Asn Ile Gly Val Ile Thr Asp Phe Glu Leu           
                325                 330                 335               

gaa gtg cgc aat gcg ctg aac agg cgg gcg cac gcc gtc ggc gcg cag       1056
Glu Val Arg Asn Ala Leu Asn Arg Arg Ala His Ala Val Gly Ala Gln           
            340                 345                 350                   

gac gtg gtc cag cat ggc act gag cag aac aat cct ttc ccg gag gca       1104
Asp Val Val Gln His Gly Thr Glu Gln Asn Asn Pro Phe Pro Glu Ala           
        355                 360                 365                       

gat gag aag att ttc gtc gta tcg gcc acc ggt aaa cgt atg cat ggt       1152
Asp Glu Lys Ile Phe Val Val Ser Ala Thr Gly Lys Arg Met His Gly           
    370                 375                 380                           

ccg aaa gcc act ctg caa gat att gtt ctg cac ttg gaa ccg caa aat       1200
Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn           
385                 390                 395                 400           

gaa att cca gtt gac ctg ctg tgt cat gaa caa ttg aaa cgt act agt       1248
Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Lys Arg Thr Ser           
                405                 410                 415               

gaa agc cag atg ctc acg cgc ggg caa ctg aag gaa tac att ggc cag       1296
Glu Ser Gln Met Leu Thr Arg Gly Gln Leu Lys Glu Tyr Ile Gly Gln           
            420                 425                 430                   

cag cgc ggc gag ggc tat gtc ttc tac gag aac cgt gca tac ggc gtg       1344
Gln Arg Gly Glu Gly Tyr Val Phe Tyr Glu Asn Arg Ala Tyr Gly Val           
        435                 440                 445                       

gcg ggg aaa agc ctg ttc gac gat ggg ctg gga gcc gcg ccc ggc gtg       1392
Ala Gly Lys Ser Leu Phe Asp Asp Gly Leu Gly Ala Ala Pro Gly Val           
    450                 455                 460                           

ccg agc gga cgt tcg aag ttc tcg ccg gat gta ctg gaa acg gtg ccg       1440
Pro Ser Gly Arg Ser Lys Phe Ser Pro Asp Val Leu Glu Thr Val Pro           
465                 470                 475                 480           

gcg tca ccc gga ttg cgg cgg ccg tcg ctg ggc gca gtg gaa cgc cag       1488
Ala Ser Pro Gly Leu Arg Arg Pro Ser Leu Gly Ala Val Glu Arg Gln           
                485                 490                 495               

gat tcc ggc tat gac agc ctt gat ggg gtg gga tcg cga tcg ttc tcg       1536
Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly Ser Arg Ser Phe Ser           
            500                 505                 510                   

ttg ggc gag gtg tcc gac atg gcc gcc gtg gaa gcg gcg gaa ctg gaa       1584
Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu Ala Ala Glu Leu Glu           
        515                 520                 525                       

atg acc cgg caa gtc ttg cac gcc ggg gcg cgg cag gac gat gcc gag       1632
Met Thr Arg Gln Val Leu His Ala Gly Ala Arg Gln Asp Asp Ala Glu           
    530                 535                 540                           

ccg ggc gtg agc ggt gcg tcg gcg cac tgg ggg cag cgg gcg ctg cag       1680
Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly Gln Arg Ala Leu Gln           
545                 550                 555                 560           

ggc gcc cag gcg gtg gcg gcg gcg cag cgg ctg gtt cat gcc att gcc       1728
Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu Val His Ala Ile Ala           
                565                 570                 575               

ctg atg acg caa ttc ggc cgg gcc ggt tcc acc aac acg ccg cag gaa       1776
Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr Asn Thr Pro Gln Glu           
            580                 585                 590                   

gcg gcc tcg ttg tcg gcg gcc gtg ttc ggc ttg ggc gag gcc agc agc       1824
Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu Gly Glu Ala Ser Ser           
        595                 600                 605                       

gcc gtg gcc gaa acc gtg agc ggt ttt ttc cgc ggg tct tcg cgc tgg       1872
Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg Gly Ser Ser Arg Trp           
    610                 615                 620                           

gcc ggc ggt ttc ggc gtg gct ggc ggc gcg atg gcg ctg gga ggc ggc       1920
Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met Ala Leu Gly Gly Gly           
625                 630                 635                 640           

atc gcc gcg gcc gtt ggc gcc ggg atg tcg ttg acc gat gac gcg ccg       1968
Ile Ala Ala Ala Val Gly Ala Gly Met Ser Leu Thr Asp Asp Ala Pro           
                645                 650                 655               

gcc gga cag aag gcc gcc gcc ggc gcc gag atc gcg ctg cag ttg aca       2016
Ala Gly Gln Lys Ala Ala Ala Gly Ala Glu Ile Ala Leu Gln Leu Thr           
            660                 665                 670                   

ggt gga acg gtc gag ctg gct tct tcc atc gcg ttg gcg ctg gcc gcg       2064
Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala Leu Ala Leu Ala Ala           
        675                 680                 685                       

gcg cgc ggc gtg acc agc ggc ttg cag gtg gcc ggg gcg tcg gcc ggg       2112
Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala Gly Ala Ser Ala Gly           
    690                 695                 700                           

gcg gct gcc ggc gca ttg gcc gcg gcg ctc agt ccc atg gag atc tac       2160
Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser Pro Met Glu Ile Tyr           
705                 710                 715                 720           

ggc ctg gtg cag caa tcg cac tat gcg gat cag ctg gac aag ctg gcg       2208
Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln Leu Asp Lys Leu Ala           
                725                 730                 735               

cag gaa tcg agc gca tac ggt tac gag ggc gac gcc ttg ctg gcc cag       2256
Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp Ala Leu Leu Ala Gln           
            740                 745                 750                   

ctg tat cgc gac aag acg gcc gcc gag ggc gcc gtc gcc ggc gtc tcc       2304
Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala Val Ala Gly Val Ser           
        755                 760                 765                       

gcc gtc ctg agc acg gtg ggg gcg gcg gtg tcg atc gcc gcg gcg gcc       2352
Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser Ile Ala Ala Ala Ala           
    770                 775                 780                           

agc gtg gta ggg gcc ccg gtg gcg gtg gtc act tcc ttg ctg acc ggg       2400
Ser Val Val Gly Ala Pro Val Ala Val Val Thr Ser Leu Leu Thr Gly           
785                 790                 795                 800           

gct ctc aac ggc atc ctg cgc ggc gtg cag cag ccc atc atc gaa aag       2448
Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln Pro Ile Ile Glu Lys           
                805                 810                 815               

ctg gcc aac gat tac gct cgc aag atc gac gag ctg ggc ggg ccg caa       2496
Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu Leu Gly Gly Pro Gln           
            820                 825                 830                   

gcg tac ttc gag aaa aac ctg cag gcg cgt cac gaa caa ctg gcc aat       2544
Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His Glu Gln Leu Ala Asn           
        835                 840                 845                       

tcg gac ggc cta cgg aaa atg ctg gcc gac ctg cag gcc ggt tgg aac       2592
Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu Gln Ala Gly Trp Asn           
    850                 855                 860                           

gcc agc agc gtg atc ggg gtg cag acg aca gag atc tcc aag tcg gcg       2640
Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu Ile Ser Lys Ser Ala           
865                 870                 875                 880           

ctc gaa ctg gcc gcc att acc ggc aac gcg gac aac ctg aaa tcc gtc       2688
Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp Asn Leu Lys Ser Val           
                885                 890                 895               

gac gtg ttc gtg gac cgc ttc gtc cag ggc gag cgg gtg gcc ggc cag       2736
Asp Val Phe Val Asp Arg Phe Val Gln Gly Glu Arg Val Ala Gly Gln           
            900                 905                 910                   

ccg gtg gtc ctc gac gtc gcc gcc ggc ggc atc gat atc gcc agc cgc       2784
Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile Asp Ile Ala Ser Arg           
        915                 920                 925                       

aag ggc gag cgg ccg gcg ctg acg ttc atc acg ccg ctg gcc gcg cca       2832
Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr Pro Leu Ala Ala Pro           
    930                 935                 940                           

gga gaa gag cag cgc cgg cgc acg aaa acg ggc aag agc gaa ttc acc       2880
Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly Lys Ser Glu Phe Thr           
945                 950                 955                 960           

aca ttc gtc gag atc gtg ggc aag cag gac cgc tgg cgc atc cgg gac       2928
Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg Trp Arg Ile Arg Asp           
                965                 970                 975               

ggc gcg gcc gac acc acc atc gat ctg gcc aag gtg gtg tcg caa ctg       2976
Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys Val Val Ser Gln Leu           
            980                 985                 990                   

gtc gac gcc aat ggc gtg ctc aag  cac agc atc aaa ctg  gat gtg atc     3024
Val Asp Ala Asn Gly Val Leu Lys  His Ser Ile Lys Leu  Asp Val Ile         
        995                 1000                 1005                     

ggc gga  gat ggc gat gac gtc  gtg ctt gcc aat gct  tcg cgc atc        3069
Gly Gly  Asp Gly Asp Asp Val  Val Leu Ala Asn Ala  Ser Arg Ile            
    1010                 1015                 1020                        

cat tat  gac ggc ggc gcg ggc  acc aac acg gtc agc  tat gcc gcc        3114
His Tyr  Asp Gly Gly Ala Gly  Thr Asn Thr Val Ser  Tyr Ala Ala            
    1025                 1030                 1035                        

ctg ggt  cga cag gat tcc att  acc gtg tcc gcc gac  ggg gaa cgt        3159
Leu Gly  Arg Gln Asp Ser Ile  Thr Val Ser Ala Asp  Gly Glu Arg            
    1040                 1045                 1050                        

ttc aac  gtg cgc aag cag ttg  aac aac gcc aac gtg  tat cgc gaa        3204
Phe Asn  Val Arg Lys Gln Leu  Asn Asn Ala Asn Val  Tyr Arg Glu            
    1055                 1060                 1065                        

ggc gtg  gct acc cag aca acc  gcc tac ggc aag cgc  acg gag aat        3249
Gly Val  Ala Thr Gln Thr Thr  Ala Tyr Gly Lys Arg  Thr Glu Asn            
    1070                 1075                 1080                        

gtc caa  tac cgc cat gtc gag  ctg gcc cgt gtc ggg  caa ctg gtg        3294
Val Gln  Tyr Arg His Val Glu  Leu Ala Arg Val Gly  Gln Leu Val            
    1085                 1090                 1095                        

gag gtc  gac acg ctc gag cat  gtg cag cac atc atc  ggc ggg gcc        3339
Glu Val  Asp Thr Leu Glu His  Val Gln His Ile Ile  Gly Gly Ala            
    1100                 1105                 1110                        

ggc aac  gat tcg atc acc ggc  aat gcg cac gac aac  ttc cta gcc        3384
Gly Asn  Asp Ser Ile Thr Gly  Asn Ala His Asp Asn  Phe Leu Ala            
    1115                 1120                 1125                        

ggc ggg  tcg ggc gac gac agg  ctg gat ggc ggc gcc  ggc aac gac        3429
Gly Gly  Ser Gly Asp Asp Arg  Leu Asp Gly Gly Ala  Gly Asn Asp            
    1130                 1135                 1140                        

acc ctg  gtt ggc ggc gag ggc  caa aac acg gtc atc  ggc ggc gcc        3474
Thr Leu  Val Gly Gly Glu Gly  Gln Asn Thr Val Ile  Gly Gly Ala            
    1145                 1150                 1155                        

ggc gac  gac gta ttc ctg cag  gac ctg ggg gta tgg  agc aac cag        3519
Gly Asp  Asp Val Phe Leu Gln  Asp Leu Gly Val Trp  Ser Asn Gln            
    1160                 1165                 1170                        

ctc gat  ggc ggc gcg ggc gtc  gat acc gtg aag tac  aac gtg cac        3564
Leu Asp  Gly Gly Ala Gly Val  Asp Thr Val Lys Tyr  Asn Val His            
    1175                 1180                 1185                        

cag cct  tcc gag gag cgc ctc  gaa cgc atg ggc gac  acg ggc atc        3609
Gln Pro  Ser Glu Glu Arg Leu  Glu Arg Met Gly Asp  Thr Gly Ile            
    1190                 1195                 1200                        

cat gcc  gat ctt caa aag ggc  acg gtc gag aag tgg  ccg gcc ctg        3654
His Ala  Asp Leu Gln Lys Gly  Thr Val Glu Lys Trp  Pro Ala Leu            
    1205                 1210                 1215                        

aac ctg  ttc agc gtc gac cat  gtc aag aat atc gag  aat ctg cac        3699
Asn Leu  Phe Ser Val Asp His  Val Lys Asn Ile Glu  Asn Leu His            
    1220                 1225                 1230                        

ggc tcc  cgc cta aac gac cgc  atc gcc ggc gac gac  cag gac aac        3744
Gly Ser  Arg Leu Asn Asp Arg  Ile Ala Gly Asp Asp  Gln Asp Asn            
    1235                 1240                 1245                        

gag ctc  tgg ggc cac gat ggc  aac gac acg ata cgc  ggc cgg ggc        3789
Glu Leu  Trp Gly His Asp Gly  Asn Asp Thr Ile Arg  Gly Arg Gly            
    1250                 1255                 1260                        

ggc gac  gac atc ctg cgc ggc  ggc ctg ggc ctg gac  acg ctg tat        3834
Gly Asp  Asp Ile Leu Arg Gly  Gly Leu Gly Leu Asp  Thr Leu Tyr            
    1265                 1270                 1275                        

ggc gag  gac ggc aac gac atc  ttc ctg cag gac gac  gag acc gtc        3879
Gly Glu  Asp Gly Asn Asp Ile  Phe Leu Gln Asp Asp  Glu Thr Val            
    1280                 1285                 1290                        

agc gat  gac atc gac ggc ggc  gcg ggg ctg gac acc  gtc gac tac        3924
Ser Asp  Asp Ile Asp Gly Gly  Ala Gly Leu Asp Thr  Val Asp Tyr            
    1295                 1300                 1305                        

tcc gcc  atg atc cat cca ggc  agg atc gtt gcg ccg  cat gaa tac        3969
Ser Ala  Met Ile His Pro Gly  Arg Ile Val Ala Pro  His Glu Tyr            
    1310                 1315                 1320                        

ggc ttc  ggg atc gag gcg gac  ctg tcc agg gaa tgg  gtg cgc aag        4014
Gly Phe  Gly Ile Glu Ala Asp  Leu Ser Arg Glu Trp  Val Arg Lys            
    1325                 1330                 1335                        

gcg tcc  gcg ctg ggc gtg gac  tat tac gat aat gtc  cgc aat gtc        4059
Ala Ser  Ala Leu Gly Val Asp  Tyr Tyr Asp Asn Val  Arg Asn Val            
    1340                 1345                 1350                        

gaa aac  gtc atc ggt acg agc  atg aag gat gtg ctc  atc ggc gac        4104
Glu Asn  Val Ile Gly Thr Ser  Met Lys Asp Val Leu  Ile Gly Asp            
    1355                 1360                 1365                        

gcg caa  gcc aat acc ctg atg  ggc cag ggc ggc gac  gat acc gtg        4149
Ala Gln  Ala Asn Thr Leu Met  Gly Gln Gly Gly Asp  Asp Thr Val            
    1370                 1375                 1380                        

cgc ggc  ggc gac ggc gat gat  ctg ctg ttc ggc ggc  gac ggc aac        4194
Arg Gly  Gly Asp Gly Asp Asp  Leu Leu Phe Gly Gly  Asp Gly Asn            
    1385                 1390                 1395                        

gac atg  ctg tat ggc gac gcc  ggc aac gac acc ctc  tac ggg ggg        4239
Asp Met  Leu Tyr Gly Asp Ala  Gly Asn Asp Thr Leu  Tyr Gly Gly            
    1400                 1405                 1410                        

ctg ggc  gac gat acc ctt gaa  ggc ggc gcg ggc aac  gat tgg ttc        4284
Leu Gly  Asp Asp Thr Leu Glu  Gly Gly Ala Gly Asn  Asp Trp Phe            
    1415                 1420                 1425                        

ggc cag  acg cag gcg cgc gag  cat gac gtg ctg cgc  ggc gga gat        4329
Gly Gln  Thr Gln Ala Arg Glu  His Asp Val Leu Arg  Gly Gly Asp            
    1430                 1435                 1440                        

ggg gtg  gat acc gtc gat tac  agc cag acc ggc gcg  cat gcc ggc        4374
Gly Val  Asp Thr Val Asp Tyr  Ser Gln Thr Gly Ala  His Ala Gly            
    1445                 1450                 1455                        

att gcc  gcg ggt cgc atc ggg  ctg ggc atc ctg gct  gac ctg ggc        4419
Ile Ala  Ala Gly Arg Ile Gly  Leu Gly Ile Leu Ala  Asp Leu Gly            
    1460                 1465                 1470                        

gcc ggc  cgc gtc gac aag ctg  ggc gag gcc ggc agc  agc gcc tac        4464
Ala Gly  Arg Val Asp Lys Leu  Gly Glu Ala Gly Ser  Ser Ala Tyr            
    1475                 1480                 1485                        

gat acg  gtt tcc ggt atc gag  aac gtg gtg ggc acg  gaa ctg gcc        4509
Asp Thr  Val Ser Gly Ile Glu  Asn Val Val Gly Thr  Glu Leu Ala            
    1490                 1495                 1500                        

gac cgc  atc acg ggc gat gcg  cag gcc aac gtg ctg  cgc ggc gcg        4554
Asp Arg  Ile Thr Gly Asp Ala  Gln Ala Asn Val Leu  Arg Gly Ala            
    1505                 1510                 1515                        

ggt ggc  gcc gac gtg ctt gcg  ggc ggc gag ggc gac  gat gtg ctg        4599
Gly Gly  Ala Asp Val Leu Ala  Gly Gly Glu Gly Asp  Asp Val Leu            
    1520                 1525                 1530                        

ctg ggc  ggc gac ggc gac gac  cag ctg tcg ggc gac  gcc gga cgc        4644
Leu Gly  Gly Asp Gly Asp Asp  Gln Leu Ser Gly Asp  Ala Gly Arg            
    1535                 1540                 1545                        

gat cgc  ttg tac ggc gaa gcc  ggt gac gac tgg ttc  ttc cag gat        4689
Asp Arg  Leu Tyr Gly Glu Ala  Gly Asp Asp Trp Phe  Phe Gln Asp            
    1550                 1555                 1560                        

gcc gcc  aat gcc ggc aat ctg  ctc gac ggc ggc gac  ggc cgc gat        4734
Ala Ala  Asn Ala Gly Asn Leu  Leu Asp Gly Gly Asp  Gly Arg Asp            
    1565                 1570                 1575                        

acc gtg  gat ttc agc ggc ccg  ggc cgg ggc ctc gac  gcc ggc gca        4779
Thr Val  Asp Phe Ser Gly Pro  Gly Arg Gly Leu Asp  Ala Gly Ala            
    1580                 1585                 1590                        

aag ggc  gta ttc ctg agc ttg  ggc aag ggg ttc gcc  agc ctg atg        4824
Lys Gly  Val Phe Leu Ser Leu  Gly Lys Gly Phe Ala  Ser Leu Met            
    1595                 1600                 1605                        

gac gaa  ccc gaa acc agc aac  gtg ttg cgc aat atc  gag aac gcc        4869
Asp Glu  Pro Glu Thr Ser Asn  Val Leu Arg Asn Ile  Glu Asn Ala            
    1610                 1615                 1620                        

gtg ggc  agc gcg cgt gat gac  gtg ctg atc ggc gac  gca ggc gcc        4914
Val Gly  Ser Ala Arg Asp Asp  Val Leu Ile Gly Asp  Ala Gly Ala            
    1625                 1630                 1635                        

aac gtc  ctc aat ggc ctg gcg  ggc aac gac gtg ctg  tcc ggc ggc        4959
Asn Val  Leu Asn Gly Leu Ala  Gly Asn Asp Val Leu  Ser Gly Gly            
    1640                 1645                 1650                        

gct ggc  gac gat gtg ctg ctg  ggc gac gag ggc tcg  gac ctg ctc        5004
Ala Gly  Asp Asp Val Leu Leu  Gly Asp Glu Gly Ser  Asp Leu Leu            
    1655                 1660                 1665                        

agc ggc  gat gcg ggc aac gac  gat ctg ttc ggc ggg  cag ggc gat        5049
Ser Gly  Asp Ala Gly Asn Asp  Asp Leu Phe Gly Gly  Gln Gly Asp            
    1670                 1675                 1680                        

gat act  tat ctg ttc ggg gtc  ggg tac ggg cac gac  acg atc tac        5094
Asp Thr  Tyr Leu Phe Gly Val  Gly Tyr Gly His Asp  Thr Ile Tyr            
    1685                 1690                 1695                        

gaa tcg  ggc ggc ggc cat gac  acc atc cgc atc aac  gcg ggg gcg        5139
Glu Ser  Gly Gly Gly His Asp  Thr Ile Arg Ile Asn  Ala Gly Ala            
    1700                 1705                 1710                        

gac cag  ctg tgg ttc gcg cgc  cag ggc aac gac ctg  gag atc cgc        5184
Asp Gln  Leu Trp Phe Ala Arg  Gln Gly Asn Asp Leu  Glu Ile Arg            
    1715                 1720                 1725                        

att ctc  ggc acc gac gat gca  ctt acc gtg cac gac  tgg tat cgc        5229
Ile Leu  Gly Thr Asp Asp Ala  Leu Thr Val His Asp  Trp Tyr Arg            
    1730                 1735                 1740                        

gac gcc  gat cac cgg gtg gaa  atc atc cat gcc gcc  aac cag gcg        5274
Asp Ala  Asp His Arg Val Glu  Ile Ile His Ala Ala  Asn Gln Ala            
    1745                 1750                 1755                        

gta gac  cag gca ggc atc gaa  aag ctg gtc gag gca  atg gcg cag        5319
Val Asp  Gln Ala Gly Ile Glu  Lys Leu Val Glu Ala  Met Ala Gln            
    1760                 1765                 1770                        

tat ccg  gac ccc ggc gcg gcg  gcg gct gcc ccg ccg  gcg gcg cgc        5364
Tyr Pro  Asp Pro Gly Ala Ala  Ala Ala Ala Pro Pro  Ala Ala Arg            
    1775                 1780                 1785                        

gtg ccg  gac acg ctg atg cag  tcc ctg gct gtc aac  tgg cgc tga        5409
Val Pro  Asp Thr Leu Met Gln  Ser Leu Ala Val Asn  Trp Arg                
    1790                 1795                 1800                        


<210>  69
<211>  1802
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  69

Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu 
1               5                   10                  15      


Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys 
            20                  25                  30          


Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr 
        35                  40                  45              


Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala 
    50                  55                  60                  


Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro 
65                  70                  75                  80  


Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala 
                85                  90                  95      


Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp 
            100                 105                 110         


Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu 
        115                 120                 125             


Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr 
    130                 135                 140                 


Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala 
145                 150                 155                 160 


Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val 
                165                 170                 175     


Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Leu Gln Ile Asp 
            180                 185                 190         


Met Phe Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg 
        195                 200                 205             


Ser Ser Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr 
    210                 215                 220                 


Arg Arg Ala Ser Gly Val Asn His Gln His Leu Pro Ala Arg Arg Ala 
225                 230                 235                 240 


Glu Pro Gln Arg His Thr Met Leu Cys Met Cys Cys Lys Cys Glu Ala 
                245                 250                 255     


Arg Ile Glu Leu Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala Phe 
            260                 265                 270         


Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe Val Cys Pro Trp Cys Ala 
        275                 280                 285             


Ser Gln Gln Gly Thr Arg Ala Arg Leu Lys Leu Leu Trp Lys Ile Ala 
    290                 295                 300                 


Arg Ala Gly Ala Arg Ser Ala Val Gly Thr Glu Ala Arg Arg Gln Phe 
305                 310                 315                 320 


Arg Tyr Asp Gly Asp Met Asn Ile Gly Val Ile Thr Asp Phe Glu Leu 
                325                 330                 335     


Glu Val Arg Asn Ala Leu Asn Arg Arg Ala His Ala Val Gly Ala Gln 
            340                 345                 350         


Asp Val Val Gln His Gly Thr Glu Gln Asn Asn Pro Phe Pro Glu Ala 
        355                 360                 365             


Asp Glu Lys Ile Phe Val Val Ser Ala Thr Gly Lys Arg Met His Gly 
    370                 375                 380                 


Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn 
385                 390                 395                 400 


Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Lys Arg Thr Ser 
                405                 410                 415     


Glu Ser Gln Met Leu Thr Arg Gly Gln Leu Lys Glu Tyr Ile Gly Gln 
            420                 425                 430         


Gln Arg Gly Glu Gly Tyr Val Phe Tyr Glu Asn Arg Ala Tyr Gly Val 
        435                 440                 445             


Ala Gly Lys Ser Leu Phe Asp Asp Gly Leu Gly Ala Ala Pro Gly Val 
    450                 455                 460                 


Pro Ser Gly Arg Ser Lys Phe Ser Pro Asp Val Leu Glu Thr Val Pro 
465                 470                 475                 480 


Ala Ser Pro Gly Leu Arg Arg Pro Ser Leu Gly Ala Val Glu Arg Gln 
                485                 490                 495     


Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly Ser Arg Ser Phe Ser 
            500                 505                 510         


Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu Ala Ala Glu Leu Glu 
        515                 520                 525             


Met Thr Arg Gln Val Leu His Ala Gly Ala Arg Gln Asp Asp Ala Glu 
    530                 535                 540                 


Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly Gln Arg Ala Leu Gln 
545                 550                 555                 560 


Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu Val His Ala Ile Ala 
                565                 570                 575     


Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr Asn Thr Pro Gln Glu 
            580                 585                 590         


Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu Gly Glu Ala Ser Ser 
        595                 600                 605             


Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg Gly Ser Ser Arg Trp 
    610                 615                 620                 


Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met Ala Leu Gly Gly Gly 
625                 630                 635                 640 


Ile Ala Ala Ala Val Gly Ala Gly Met Ser Leu Thr Asp Asp Ala Pro 
                645                 650                 655     


Ala Gly Gln Lys Ala Ala Ala Gly Ala Glu Ile Ala Leu Gln Leu Thr 
            660                 665                 670         


Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala Leu Ala Leu Ala Ala 
        675                 680                 685             


Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala Gly Ala Ser Ala Gly 
    690                 695                 700                 


Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser Pro Met Glu Ile Tyr 
705                 710                 715                 720 


Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln Leu Asp Lys Leu Ala 
                725                 730                 735     


Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp Ala Leu Leu Ala Gln 
            740                 745                 750         


Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala Val Ala Gly Val Ser 
        755                 760                 765             


Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser Ile Ala Ala Ala Ala 
    770                 775                 780                 


Ser Val Val Gly Ala Pro Val Ala Val Val Thr Ser Leu Leu Thr Gly 
785                 790                 795                 800 


Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln Pro Ile Ile Glu Lys 
                805                 810                 815     


Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu Leu Gly Gly Pro Gln 
            820                 825                 830         


Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His Glu Gln Leu Ala Asn 
        835                 840                 845             


Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu Gln Ala Gly Trp Asn 
    850                 855                 860                 


Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu Ile Ser Lys Ser Ala 
865                 870                 875                 880 


Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp Asn Leu Lys Ser Val 
                885                 890                 895     


Asp Val Phe Val Asp Arg Phe Val Gln Gly Glu Arg Val Ala Gly Gln 
            900                 905                 910         


Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile Asp Ile Ala Ser Arg 
        915                 920                 925             


Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr Pro Leu Ala Ala Pro 
    930                 935                 940                 


Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly Lys Ser Glu Phe Thr 
945                 950                 955                 960 


Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg Trp Arg Ile Arg Asp 
                965                 970                 975     


Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys Val Val Ser Gln Leu 
            980                 985                 990         


Val Asp Ala Asn Gly Val Leu Lys  His Ser Ile Lys Leu  Asp Val Ile 
        995                 1000                 1005             


Gly Gly  Asp Gly Asp Asp Val  Val Leu Ala Asn Ala  Ser Arg Ile 
    1010                 1015                 1020             


His Tyr  Asp Gly Gly Ala Gly  Thr Asn Thr Val Ser  Tyr Ala Ala 
    1025                 1030                 1035             


Leu Gly  Arg Gln Asp Ser Ile  Thr Val Ser Ala Asp  Gly Glu Arg 
    1040                 1045                 1050             


Phe Asn  Val Arg Lys Gln Leu  Asn Asn Ala Asn Val  Tyr Arg Glu 
    1055                 1060                 1065             


Gly Val  Ala Thr Gln Thr Thr  Ala Tyr Gly Lys Arg  Thr Glu Asn 
    1070                 1075                 1080             


Val Gln  Tyr Arg His Val Glu  Leu Ala Arg Val Gly  Gln Leu Val 
    1085                 1090                 1095             


Glu Val  Asp Thr Leu Glu His  Val Gln His Ile Ile  Gly Gly Ala 
    1100                 1105                 1110             


Gly Asn  Asp Ser Ile Thr Gly  Asn Ala His Asp Asn  Phe Leu Ala 
    1115                 1120                 1125             


Gly Gly  Ser Gly Asp Asp Arg  Leu Asp Gly Gly Ala  Gly Asn Asp 
    1130                 1135                 1140             


Thr Leu  Val Gly Gly Glu Gly  Gln Asn Thr Val Ile  Gly Gly Ala 
    1145                 1150                 1155             


Gly Asp  Asp Val Phe Leu Gln  Asp Leu Gly Val Trp  Ser Asn Gln 
    1160                 1165                 1170             


Leu Asp  Gly Gly Ala Gly Val  Asp Thr Val Lys Tyr  Asn Val His 
    1175                 1180                 1185             


Gln Pro  Ser Glu Glu Arg Leu  Glu Arg Met Gly Asp  Thr Gly Ile 
    1190                 1195                 1200             


His Ala  Asp Leu Gln Lys Gly  Thr Val Glu Lys Trp  Pro Ala Leu 
    1205                 1210                 1215             


Asn Leu  Phe Ser Val Asp His  Val Lys Asn Ile Glu  Asn Leu His 
    1220                 1225                 1230             


Gly Ser  Arg Leu Asn Asp Arg  Ile Ala Gly Asp Asp  Gln Asp Asn 
    1235                 1240                 1245             


Glu Leu  Trp Gly His Asp Gly  Asn Asp Thr Ile Arg  Gly Arg Gly 
    1250                 1255                 1260             


Gly Asp  Asp Ile Leu Arg Gly  Gly Leu Gly Leu Asp  Thr Leu Tyr 
    1265                 1270                 1275             


Gly Glu  Asp Gly Asn Asp Ile  Phe Leu Gln Asp Asp  Glu Thr Val 
    1280                 1285                 1290             


Ser Asp  Asp Ile Asp Gly Gly  Ala Gly Leu Asp Thr  Val Asp Tyr 
    1295                 1300                 1305             


Ser Ala  Met Ile His Pro Gly  Arg Ile Val Ala Pro  His Glu Tyr 
    1310                 1315                 1320             


Gly Phe  Gly Ile Glu Ala Asp  Leu Ser Arg Glu Trp  Val Arg Lys 
    1325                 1330                 1335             


Ala Ser  Ala Leu Gly Val Asp  Tyr Tyr Asp Asn Val  Arg Asn Val 
    1340                 1345                 1350             


Glu Asn  Val Ile Gly Thr Ser  Met Lys Asp Val Leu  Ile Gly Asp 
    1355                 1360                 1365             


Ala Gln  Ala Asn Thr Leu Met  Gly Gln Gly Gly Asp  Asp Thr Val 
    1370                 1375                 1380             


Arg Gly  Gly Asp Gly Asp Asp  Leu Leu Phe Gly Gly  Asp Gly Asn 
    1385                 1390                 1395             


Asp Met  Leu Tyr Gly Asp Ala  Gly Asn Asp Thr Leu  Tyr Gly Gly 
    1400                 1405                 1410             


Leu Gly  Asp Asp Thr Leu Glu  Gly Gly Ala Gly Asn  Asp Trp Phe 
    1415                 1420                 1425             


Gly Gln  Thr Gln Ala Arg Glu  His Asp Val Leu Arg  Gly Gly Asp 
    1430                 1435                 1440             


Gly Val  Asp Thr Val Asp Tyr  Ser Gln Thr Gly Ala  His Ala Gly 
    1445                 1450                 1455             


Ile Ala  Ala Gly Arg Ile Gly  Leu Gly Ile Leu Ala  Asp Leu Gly 
    1460                 1465                 1470             


Ala Gly  Arg Val Asp Lys Leu  Gly Glu Ala Gly Ser  Ser Ala Tyr 
    1475                 1480                 1485             


Asp Thr  Val Ser Gly Ile Glu  Asn Val Val Gly Thr  Glu Leu Ala 
    1490                 1495                 1500             


Asp Arg  Ile Thr Gly Asp Ala  Gln Ala Asn Val Leu  Arg Gly Ala 
    1505                 1510                 1515             


Gly Gly  Ala Asp Val Leu Ala  Gly Gly Glu Gly Asp  Asp Val Leu 
    1520                 1525                 1530             


Leu Gly  Gly Asp Gly Asp Asp  Gln Leu Ser Gly Asp  Ala Gly Arg 
    1535                 1540                 1545             


Asp Arg  Leu Tyr Gly Glu Ala  Gly Asp Asp Trp Phe  Phe Gln Asp 
    1550                 1555                 1560             


Ala Ala  Asn Ala Gly Asn Leu  Leu Asp Gly Gly Asp  Gly Arg Asp 
    1565                 1570                 1575             


Thr Val  Asp Phe Ser Gly Pro  Gly Arg Gly Leu Asp  Ala Gly Ala 
    1580                 1585                 1590             


Lys Gly  Val Phe Leu Ser Leu  Gly Lys Gly Phe Ala  Ser Leu Met 
    1595                 1600                 1605             


Asp Glu  Pro Glu Thr Ser Asn  Val Leu Arg Asn Ile  Glu Asn Ala 
    1610                 1615                 1620             


Val Gly  Ser Ala Arg Asp Asp  Val Leu Ile Gly Asp  Ala Gly Ala 
    1625                 1630                 1635             


Asn Val  Leu Asn Gly Leu Ala  Gly Asn Asp Val Leu  Ser Gly Gly 
    1640                 1645                 1650             


Ala Gly  Asp Asp Val Leu Leu  Gly Asp Glu Gly Ser  Asp Leu Leu 
    1655                 1660                 1665             


Ser Gly  Asp Ala Gly Asn Asp  Asp Leu Phe Gly Gly  Gln Gly Asp 
    1670                 1675                 1680             


Asp Thr  Tyr Leu Phe Gly Val  Gly Tyr Gly His Asp  Thr Ile Tyr 
    1685                 1690                 1695             


Glu Ser  Gly Gly Gly His Asp  Thr Ile Arg Ile Asn  Ala Gly Ala 
    1700                 1705                 1710             


Asp Gln  Leu Trp Phe Ala Arg  Gln Gly Asn Asp Leu  Glu Ile Arg 
    1715                 1720                 1725             


Ile Leu  Gly Thr Asp Asp Ala  Leu Thr Val His Asp  Trp Tyr Arg 
    1730                 1735                 1740             


Asp Ala  Asp His Arg Val Glu  Ile Ile His Ala Ala  Asn Gln Ala 
    1745                 1750                 1755             


Val Asp  Gln Ala Gly Ile Glu  Lys Leu Val Glu Ala  Met Ala Gln 
    1760                 1765                 1770             


Tyr Pro  Asp Pro Gly Ala Ala  Ala Ala Ala Pro Pro  Ala Ala Arg 
    1775                 1780                 1785             


Val Pro  Asp Thr Leu Met Gln  Ser Leu Ala Val Asn  Trp Arg 
    1790                 1795                 1800         


<210>  70
<211>  4512
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding polypeptides 1-183 + 387-1706 of 
       CyaA


<220>
<221>  CDS
<222>  (1)..(4512)

<400>  70
atg cag cag tcc cat cag gcc ggt tac gca aac gca gcc gat cgt gaa         48
Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu           
1               5                   10                  15                

tct ggt atc ccg gca gcg gtt ctg gat ggt att aag gca gtt gcc aaa         96
Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys           
            20                  25                  30                    

gag aag aac gct acc ctg atg ttc cgt ctg gtc aac cca cac tct act        144
Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr           
        35                  40                  45                        

tcc ctg atc gcg gaa ggt gtg gcg acc aaa ggc ctg ggt gtg cac gcc        192
Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala           
    50                  55                  60                            

aaa agc agc gac tgg ggt ctg cag gca ggt tat att ccg gtg aac ccg        240
Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro           
65                  70                  75                  80            

aat ctg tct aaa ctg ttc ggt cgt gcc ccg gag gtg atc gca cgt gca        288
Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala           
                85                  90                  95                

gac aac gat gtc aac tct tct ctg gcg cat ggt cac acc gcg gtt gat        336
Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp           
            100                 105                 110                   

ctg acc ctg tcc aaa gaa cgc ctg gat tac ctg cgt cag gcg ggc ctg        384
Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu           
        115                 120                 125                       

gtg acg ggc atg gcc gac ggt gtt gta gcg agc aac cac gcg ggt tat        432
Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr           
    130                 135                 140                           

gaa caa ttt gag ttt cgc gtt aaa gag acc tct gac ggt cgt tac gcg        480
Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala           
145                 150                 155                 160           

gtg cag tac cgc cgc aaa ggt ggc gat gac ttt gaa gct gtc aaa gtg        528
Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val           
                165                 170                 175               

atc ggt aac gct gct gga att ccg ggc ctg cgc cgt ccg tcc ctg ggc        576
Ile Gly Asn Ala Ala Gly Ile Pro Gly Leu Arg Arg Pro Ser Leu Gly           
            180                 185                 190                   

gca gtc gaa cgt cag gac tcc ggc tac gat tcc ctg gat ggc gtt ggc        624
Ala Val Glu Arg Gln Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly           
        195                 200                 205                       

tcc cgc tcc ttc tcc ctg ggc gag gtt tct gac atg gct gcg gtg gaa        672
Ser Arg Ser Phe Ser Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu           
    210                 215                 220                           

gcg gca gag ctg gaa atg acc cgt caa gtg ctg cac gcg ggc gca cgt        720
Ala Ala Glu Leu Glu Met Thr Arg Gln Val Leu His Ala Gly Ala Arg           
225                 230                 235                 240           

cag gac gat gct gag ccg ggc gtg tcc ggt gcg tct gca cac tgg ggt        768
Gln Asp Asp Ala Glu Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly           
                245                 250                 255               

caa cgt gcc ctg cag ggt gct caa gct gtc gcg gca gcg cag cgt ctg        816
Gln Arg Ala Leu Gln Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu           
            260                 265                 270                   

gta cat gcg atc gca ctg atg acc cag ttc ggt cgc gca ggt tct acc        864
Val His Ala Ile Ala Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr           
        275                 280                 285                       

aac act cct cag gaa gca gct agc ctg tct gct gct gtt ttc ggt ctg        912
Asn Thr Pro Gln Glu Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu           
    290                 295                 300                           

ggc gaa gcg tct tct gcg gtt gca gaa acc gtg agc ggt ttc ttc cgt        960
Gly Glu Ala Ser Ser Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg           
305                 310                 315                 320           

ggt tct agc cgc tgg gcg ggt ggt ttt ggt gta gca ggt ggc gct atg       1008
Gly Ser Ser Arg Trp Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met           
                325                 330                 335               

gcc ctg ggt ggc ggt atc gcg gct gct gtc ggc gca ggt atg agc ctg       1056
Ala Leu Gly Gly Gly Ile Ala Ala Ala Val Gly Ala Gly Met Ser Leu           
            340                 345                 350                   

acc gac gat gct cct gcg ggc cag aaa gcc gca gct ggc gct gaa atc       1104
Thr Asp Asp Ala Pro Ala Gly Gln Lys Ala Ala Ala Gly Ala Glu Ile           
        355                 360                 365                       

gcg ctg cag ctg act ggt ggt acc gtt gaa ctg gct agc tct atc gcg       1152
Ala Leu Gln Leu Thr Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala           
    370                 375                 380                           

ctg gct ctg gca gcg gca cgt ggc gtg act tct ggc ctg caa gtc gcc       1200
Leu Ala Leu Ala Ala Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala           
385                 390                 395                 400           

ggt gcc tct gcg ggc gct gct gcg ggc gct ctg gca gct gca ctg tcc       1248
Gly Ala Ser Ala Gly Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser           
                405                 410                 415               

ccc atg gaa atc tac ggt ctg gta cag cag tct cac tac gca gac cag       1296
Pro Met Glu Ile Tyr Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln           
            420                 425                 430                   

ctg gat aaa ctg gcg cag gag tct tct gca tac ggt tac gaa ggc gac       1344
Leu Asp Lys Leu Ala Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp           
        435                 440                 445                       

gca ctg ctg gcg cag ctg tat cgt gac aaa act gct gct gaa ggt gct       1392
Ala Leu Leu Ala Gln Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala           
    450                 455                 460                           

gtg gca ggc gtt tct gcg gta ctg tct acc gtt ggc gct gcg gtt tct       1440
Val Ala Gly Val Ser Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser           
465                 470                 475                 480           

att gcg gct gcc gca tcc gtt gta ggt gcg ccg gtt gct gta gtt acc       1488
Ile Ala Ala Ala Ala Ser Val Val Gly Ala Pro Val Ala Val Val Thr           
                485                 490                 495               

tct ctg ctg act ggt gca ctg aac ggt atc ctg cgt ggt gtt cag cag       1536
Ser Leu Leu Thr Gly Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln           
            500                 505                 510                   

cct att atc gaa aaa ctg gcg aat gat tat gcc cgt aaa atc gac gaa       1584
Pro Ile Ile Glu Lys Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu           
        515                 520                 525                       

ctg ggc ggt ccg cag gct tat ttt gaa aaa aac ctg cag gcg cgc cac       1632
Leu Gly Gly Pro Gln Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His           
    530                 535                 540                           

gaa cag ctg gca aac agc gac ggc ctg cgc aaa atg ctg gca gac ctg       1680
Glu Gln Leu Ala Asn Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu           
545                 550                 555                 560           

caa gct ggt tgg aac gcg tct tct gtg atc ggc gtg cag acc acc gaa       1728
Gln Ala Gly Trp Asn Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu           
                565                 570                 575               

att agc aaa tct gcg ctg gaa ctg gct gca att act ggc aac gcg gat       1776
Ile Ser Lys Ser Ala Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp           
            580                 585                 590                   

aac ctg aaa agc gtt gat gtt ttt gtc gat cgc ttc gtt cag ggc gag       1824
Asn Leu Lys Ser Val Asp Val Phe Val Asp Arg Phe Val Gln Gly Glu           
        595                 600                 605                       

cgc gtt gct ggt cag ccg gtt gtt ctg gac gtt gcg gca ggc ggc atc       1872
Arg Val Ala Gly Gln Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile           
    610                 615                 620                           

gac atc gct agc cgc aag ggc gag cgt ccg gct ctg act ttc att acc       1920
Asp Ile Ala Ser Arg Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr           
625                 630                 635                 640           

ccg ctg gca gct ccg ggt gaa gaa cag cgt cgc cgt acc aag act ggt       1968
Pro Leu Ala Ala Pro Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly           
                645                 650                 655               

aaa agc gag ttc acc acc ttc gtg gaa atc gta ggt aaa cag gac cgc       2016
Lys Ser Glu Phe Thr Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg           
            660                 665                 670                   

tgg cgt att cgc gac ggt gcg gcg gac acc acc atc gac ctg gca aaa       2064
Trp Arg Ile Arg Asp Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys           
        675                 680                 685                       

gtt gtt tcc caa ctg gta gat gct aac ggc gtg ctg aaa cat tct att       2112
Val Val Ser Gln Leu Val Asp Ala Asn Gly Val Leu Lys His Ser Ile           
    690                 695                 700                           

aaa ctg gat gta atc ggc ggt gac ggc gat gac gtt gta ctg gcg aac       2160
Lys Leu Asp Val Ile Gly Gly Asp Gly Asp Asp Val Val Leu Ala Asn           
705                 710                 715                 720           

gcg tct cgt atc cac tat gac ggc ggc gca ggt acc aac acg gtt tcc       2208
Ala Ser Arg Ile His Tyr Asp Gly Gly Ala Gly Thr Asn Thr Val Ser           
                725                 730                 735               

tac gca gcg ctg ggc cgc cag gat tcc atc act gtt agc gcc gat ggc       2256
Tyr Ala Ala Leu Gly Arg Gln Asp Ser Ile Thr Val Ser Ala Asp Gly           
            740                 745                 750                   

gaa cgt ttc aac gtg cgt aaa cag ctg aat aac gca aac gtc tat cgt       2304
Glu Arg Phe Asn Val Arg Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg           
        755                 760                 765                       

gag ggt gta gct acc cag acc acc gcg tac ggt aag cgt acc gaa aac       2352
Glu Gly Val Ala Thr Gln Thr Thr Ala Tyr Gly Lys Arg Thr Glu Asn           
    770                 775                 780                           

gtt cag tat cgt cac gtg gaa ctg gca cgt gtg ggt cag ctg gta gag       2400
Val Gln Tyr Arg His Val Glu Leu Ala Arg Val Gly Gln Leu Val Glu           
785                 790                 795                 800           

gtg gat acg ctg gaa cac gtg cag cac atc atc ggt ggc gcc ggt aac       2448
Val Asp Thr Leu Glu His Val Gln His Ile Ile Gly Gly Ala Gly Asn           
                805                 810                 815               

gat tcc att act ggt aac gct cac gac aac ttc ctg gca ggt ggt tct       2496
Asp Ser Ile Thr Gly Asn Ala His Asp Asn Phe Leu Ala Gly Gly Ser           
            820                 825                 830                   

ggt gat gat cgt ctg gac ggt ggt gcg ggt aac gat acg ctg gta ggc       2544
Gly Asp Asp Arg Leu Asp Gly Gly Ala Gly Asn Asp Thr Leu Val Gly           
        835                 840                 845                       

ggc gaa ggt cag aac acc gta att ggt ggt gcc ggt gac gac gtt ttc       2592
Gly Glu Gly Gln Asn Thr Val Ile Gly Gly Ala Gly Asp Asp Val Phe           
    850                 855                 860                           

ctg cag gat ctg ggc gtt tgg agc aac cag ctg gat ggc ggt gcc ggt       2640
Leu Gln Asp Leu Gly Val Trp Ser Asn Gln Leu Asp Gly Gly Ala Gly           
865                 870                 875                 880           

gtt gac acg gtt aag tat aac gtt cac cag ccg tct gaa gag cgc ctg       2688
Val Asp Thr Val Lys Tyr Asn Val His Gln Pro Ser Glu Glu Arg Leu           
                885                 890                 895               

gaa cgt atg ggt gac act ggt att cat gcc gat ctg cag aaa ggc act       2736
Glu Arg Met Gly Asp Thr Gly Ile His Ala Asp Leu Gln Lys Gly Thr           
            900                 905                 910                   

gtt gaa aaa tgg cct gcg ctg aac ctg ttc tct gtg gac cat gtt aag       2784
Val Glu Lys Trp Pro Ala Leu Asn Leu Phe Ser Val Asp His Val Lys           
        915                 920                 925                       

aac att gaa aac ctg cat ggc tct cgc ctg aac gac cgt atc gct ggt       2832
Asn Ile Glu Asn Leu His Gly Ser Arg Leu Asn Asp Arg Ile Ala Gly           
    930                 935                 940                           

gac gac cag gat aac gaa ctg tgg ggt cat gac ggc aat gat acc att       2880
Asp Asp Gln Asp Asn Glu Leu Trp Gly His Asp Gly Asn Asp Thr Ile           
945                 950                 955                 960           

cgc ggt cgt ggc ggc gac gat att ctg cgt ggc ggt ctg ggc ctg gat       2928
Arg Gly Arg Gly Gly Asp Asp Ile Leu Arg Gly Gly Leu Gly Leu Asp           
                965                 970                 975               

acc ctg tat ggt gaa gat ggt aac gat att ttc ctg caa gac gat gaa       2976
Thr Leu Tyr Gly Glu Asp Gly Asn Asp Ile Phe Leu Gln Asp Asp Glu           
            980                 985                 990                   

acg gta tct gat gac atc gac ggt  ggt gca ggc ctg gac  acc gta gat     3024
Thr Val Ser Asp Asp Ile Asp Gly  Gly Ala Gly Leu Asp  Thr Val Asp         
        995                 1000                 1005                     

tac agc  gct atg atc cat ccg  ggt cgt atc gta gct  ccg cac gag        3069
Tyr Ser  Ala Met Ile His Pro  Gly Arg Ile Val Ala  Pro His Glu            
    1010                 1015                 1020                        

tac ggc  ttc ggt atc gag gcg  gac ctg tct cgt gaa  tgg gtt cgt        3114
Tyr Gly  Phe Gly Ile Glu Ala  Asp Leu Ser Arg Glu  Trp Val Arg            
    1025                 1030                 1035                        

aaa gcg  tcc gcg ctg ggt gtg  gac tac tac gat aac  gtt cgt aac        3159
Lys Ala  Ser Ala Leu Gly Val  Asp Tyr Tyr Asp Asn  Val Arg Asn            
    1040                 1045                 1050                        

gtg gaa  aac gtg atc ggt acc  tcc atg aaa gac gtg  ctg att ggc        3204
Val Glu  Asn Val Ile Gly Thr  Ser Met Lys Asp Val  Leu Ile Gly            
    1055                 1060                 1065                        

gac gca  cag gcc aac act ctg  atg ggc cag ggc ggt  gat gac acg        3249
Asp Ala  Gln Ala Asn Thr Leu  Met Gly Gln Gly Gly  Asp Asp Thr            
    1070                 1075                 1080                        

gtt cgc  ggc ggc gac ggt gat  gac ctg ctg ttc ggt  ggt gac ggc        3294
Val Arg  Gly Gly Asp Gly Asp  Asp Leu Leu Phe Gly  Gly Asp Gly            
    1085                 1090                 1095                        

aac gac  atg ctg tac ggc gac  gcg ggc aac gac acc  ctg tac ggc        3339
Asn Asp  Met Leu Tyr Gly Asp  Ala Gly Asn Asp Thr  Leu Tyr Gly            
    1100                 1105                 1110                        

ggt ctg  ggt gac gac act ctg  gaa ggt ggt gca ggt  aac gac tgg        3384
Gly Leu  Gly Asp Asp Thr Leu  Glu Gly Gly Ala Gly  Asn Asp Trp            
    1115                 1120                 1125                        

ttc ggc  caa acc cag gca cgc  gaa cac gac gtg ctg  cgt ggt ggc        3429
Phe Gly  Gln Thr Gln Ala Arg  Glu His Asp Val Leu  Arg Gly Gly            
    1130                 1135                 1140                        

gac ggc  gta gac acc gtg gat  tac tcc caa act ggc  gct cac gcg        3474
Asp Gly  Val Asp Thr Val Asp  Tyr Ser Gln Thr Gly  Ala His Ala            
    1145                 1150                 1155                        

ggt atc  gcg gcc ggt cgt atc  ggt ctg ggc att ctg  gcc gat ctg        3519
Gly Ile  Ala Ala Gly Arg Ile  Gly Leu Gly Ile Leu  Ala Asp Leu            
    1160                 1165                 1170                        

ggt gcc  ggc cgt gtc gac aaa  ctg ggt gag gct ggc  tct agc gcc        3564
Gly Ala  Gly Arg Val Asp Lys  Leu Gly Glu Ala Gly  Ser Ser Ala            
    1175                 1180                 1185                        

tat gat  act gtt tcc ggc atc  gaa aac gtg gta ggc  act gaa ctg        3609
Tyr Asp  Thr Val Ser Gly Ile  Glu Asn Val Val Gly  Thr Glu Leu            
    1190                 1195                 1200                        

gca gat  cgt atc acg ggt gac  gcg caa gcg aac gtt  ctg cgt ggt        3654
Ala Asp  Arg Ile Thr Gly Asp  Ala Gln Ala Asn Val  Leu Arg Gly            
    1205                 1210                 1215                        

gct ggc  ggt gca gac gtg ctg  gcg ggt ggt gaa ggc  gac gac gta        3699
Ala Gly  Gly Ala Asp Val Leu  Ala Gly Gly Glu Gly  Asp Asp Val            
    1220                 1225                 1230                        

ctg ctg  ggc ggt gac ggt gac  gat cag ctg agc ggt  gat gcg ggt        3744
Leu Leu  Gly Gly Asp Gly Asp  Asp Gln Leu Ser Gly  Asp Ala Gly            
    1235                 1240                 1245                        

cgt gac  cgt ctg tac ggt gaa  gca ggt gac gat tgg  ttc ttc cag        3789
Arg Asp  Arg Leu Tyr Gly Glu  Ala Gly Asp Asp Trp  Phe Phe Gln            
    1250                 1255                 1260                        

gac gct  gct aac gct ggc aac  ctg ctg gac ggc ggc  gat ggc cgt        3834
Asp Ala  Ala Asn Ala Gly Asn  Leu Leu Asp Gly Gly  Asp Gly Arg            
    1265                 1270                 1275                        

gac act  gtt gac ttc agc ggt  ccg ggt cgc ggt ctg  gac gca ggc        3879
Asp Thr  Val Asp Phe Ser Gly  Pro Gly Arg Gly Leu  Asp Ala Gly            
    1280                 1285                 1290                        

gcg aaa  ggc gtt ttc ctg agc  ctg ggt aag ggt ttc  gca tct ctg        3924
Ala Lys  Gly Val Phe Leu Ser  Leu Gly Lys Gly Phe  Ala Ser Leu            
    1295                 1300                 1305                        

atg gac  gaa cca gaa acc agc  aat gtc ctg cgt aac  atc gaa aac        3969
Met Asp  Glu Pro Glu Thr Ser  Asn Val Leu Arg Asn  Ile Glu Asn            
    1310                 1315                 1320                        

gct gtc  ggt tcc gca cgc gat  gat gtt ctg att ggc  gat gct ggt        4014
Ala Val  Gly Ser Ala Arg Asp  Asp Val Leu Ile Gly  Asp Ala Gly            
    1325                 1330                 1335                        

gcc aat  gtt ctg aac ggt ctg  gcg ggt aat gat gta  ctg tct ggt        4059
Ala Asn  Val Leu Asn Gly Leu  Ala Gly Asn Asp Val  Leu Ser Gly            
    1340                 1345                 1350                        

ggc gct  ggt gat gat gtc ctg  ctg ggt gat gag ggc  agc gat ctg        4104
Gly Ala  Gly Asp Asp Val Leu  Leu Gly Asp Glu Gly  Ser Asp Leu            
    1355                 1360                 1365                        

ctg tcc  ggc gat gcc ggc aac  gac gat ctg ttc ggt  ggc caa ggt        4149
Leu Ser  Gly Asp Ala Gly Asn  Asp Asp Leu Phe Gly  Gly Gln Gly            
    1370                 1375                 1380                        

gat gat  act tac ctg ttc ggc  gtt ggc tat ggt cat  gac acc atc        4194
Asp Asp  Thr Tyr Leu Phe Gly  Val Gly Tyr Gly His  Asp Thr Ile            
    1385                 1390                 1395                        

tat gag  tct ggt ggc ggc cac  gat acg att cgt att  aat gca ggt        4239
Tyr Glu  Ser Gly Gly Gly His  Asp Thr Ile Arg Ile  Asn Ala Gly            
    1400                 1405                 1410                        

gct gac  caa ctg tgg ttt gca  cgt cag ggt aac gat  ctg gaa att        4284
Ala Asp  Gln Leu Trp Phe Ala  Arg Gln Gly Asn Asp  Leu Glu Ile            
    1415                 1420                 1425                        

cgc atc  ctg ggt act gat gac  gct ctg acc gta cac  gac tgg tac        4329
Arg Ile  Leu Gly Thr Asp Asp  Ala Leu Thr Val His  Asp Trp Tyr            
    1430                 1435                 1440                        

cgc gat  gcg gat cac cgc gta  gaa atc atc cat gcg  gct aac caa        4374
Arg Asp  Ala Asp His Arg Val  Glu Ile Ile His Ala  Ala Asn Gln            
    1445                 1450                 1455                        

gct gta  gac cag gct ggt att  gaa aaa ctg gta gaa  gcg atg gca        4419
Ala Val  Asp Gln Ala Gly Ile  Glu Lys Leu Val Glu  Ala Met Ala            
    1460                 1465                 1470                        

cag tat  ccg gac cca ggt gcg  gct gct gca gca cct  cca gcg gct        4464
Gln Tyr  Pro Asp Pro Gly Ala  Ala Ala Ala Ala Pro  Pro Ala Ala            
    1475                 1480                 1485                        

cgt gtg  ccg gat acc ctg atg  cag agc ctg gcc gtc  aat tgg cgt        4509
Arg Val  Pro Asp Thr Leu Met  Gln Ser Leu Ala Val  Asn Trp Arg            
    1490                 1495                 1500                        

taa                                                                   4512


<210>  71
<211>  1503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  71

Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu 
1               5                   10                  15      


Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys 
            20                  25                  30          


Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr 
        35                  40                  45              


Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala 
    50                  55                  60                  


Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro 
65                  70                  75                  80  


Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala 
                85                  90                  95      


Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp 
            100                 105                 110         


Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu 
        115                 120                 125             


Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr 
    130                 135                 140                 


Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala 
145                 150                 155                 160 


Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val 
                165                 170                 175     


Ile Gly Asn Ala Ala Gly Ile Pro Gly Leu Arg Arg Pro Ser Leu Gly 
            180                 185                 190         


Ala Val Glu Arg Gln Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly 
        195                 200                 205             


Ser Arg Ser Phe Ser Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu 
    210                 215                 220                 


Ala Ala Glu Leu Glu Met Thr Arg Gln Val Leu His Ala Gly Ala Arg 
225                 230                 235                 240 


Gln Asp Asp Ala Glu Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly 
                245                 250                 255     


Gln Arg Ala Leu Gln Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu 
            260                 265                 270         


Val His Ala Ile Ala Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr 
        275                 280                 285             


Asn Thr Pro Gln Glu Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu 
    290                 295                 300                 


Gly Glu Ala Ser Ser Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg 
305                 310                 315                 320 


Gly Ser Ser Arg Trp Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met 
                325                 330                 335     


Ala Leu Gly Gly Gly Ile Ala Ala Ala Val Gly Ala Gly Met Ser Leu 
            340                 345                 350         


Thr Asp Asp Ala Pro Ala Gly Gln Lys Ala Ala Ala Gly Ala Glu Ile 
        355                 360                 365             


Ala Leu Gln Leu Thr Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala 
    370                 375                 380                 


Leu Ala Leu Ala Ala Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala 
385                 390                 395                 400 


Gly Ala Ser Ala Gly Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser 
                405                 410                 415     


Pro Met Glu Ile Tyr Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln 
            420                 425                 430         


Leu Asp Lys Leu Ala Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp 
        435                 440                 445             


Ala Leu Leu Ala Gln Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala 
    450                 455                 460                 


Val Ala Gly Val Ser Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser 
465                 470                 475                 480 


Ile Ala Ala Ala Ala Ser Val Val Gly Ala Pro Val Ala Val Val Thr 
                485                 490                 495     


Ser Leu Leu Thr Gly Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln 
            500                 505                 510         


Pro Ile Ile Glu Lys Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu 
        515                 520                 525             


Leu Gly Gly Pro Gln Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His 
    530                 535                 540                 


Glu Gln Leu Ala Asn Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu 
545                 550                 555                 560 


Gln Ala Gly Trp Asn Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu 
                565                 570                 575     


Ile Ser Lys Ser Ala Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp 
            580                 585                 590         


Asn Leu Lys Ser Val Asp Val Phe Val Asp Arg Phe Val Gln Gly Glu 
        595                 600                 605             


Arg Val Ala Gly Gln Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile 
    610                 615                 620                 


Asp Ile Ala Ser Arg Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr 
625                 630                 635                 640 


Pro Leu Ala Ala Pro Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly 
                645                 650                 655     


Lys Ser Glu Phe Thr Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg 
            660                 665                 670         


Trp Arg Ile Arg Asp Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys 
        675                 680                 685             


Val Val Ser Gln Leu Val Asp Ala Asn Gly Val Leu Lys His Ser Ile 
    690                 695                 700                 


Lys Leu Asp Val Ile Gly Gly Asp Gly Asp Asp Val Val Leu Ala Asn 
705                 710                 715                 720 


Ala Ser Arg Ile His Tyr Asp Gly Gly Ala Gly Thr Asn Thr Val Ser 
                725                 730                 735     


Tyr Ala Ala Leu Gly Arg Gln Asp Ser Ile Thr Val Ser Ala Asp Gly 
            740                 745                 750         


Glu Arg Phe Asn Val Arg Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg 
        755                 760                 765             


Glu Gly Val Ala Thr Gln Thr Thr Ala Tyr Gly Lys Arg Thr Glu Asn 
    770                 775                 780                 


Val Gln Tyr Arg His Val Glu Leu Ala Arg Val Gly Gln Leu Val Glu 
785                 790                 795                 800 


Val Asp Thr Leu Glu His Val Gln His Ile Ile Gly Gly Ala Gly Asn 
                805                 810                 815     


Asp Ser Ile Thr Gly Asn Ala His Asp Asn Phe Leu Ala Gly Gly Ser 
            820                 825                 830         


Gly Asp Asp Arg Leu Asp Gly Gly Ala Gly Asn Asp Thr Leu Val Gly 
        835                 840                 845             


Gly Glu Gly Gln Asn Thr Val Ile Gly Gly Ala Gly Asp Asp Val Phe 
    850                 855                 860                 


Leu Gln Asp Leu Gly Val Trp Ser Asn Gln Leu Asp Gly Gly Ala Gly 
865                 870                 875                 880 


Val Asp Thr Val Lys Tyr Asn Val His Gln Pro Ser Glu Glu Arg Leu 
                885                 890                 895     


Glu Arg Met Gly Asp Thr Gly Ile His Ala Asp Leu Gln Lys Gly Thr 
            900                 905                 910         


Val Glu Lys Trp Pro Ala Leu Asn Leu Phe Ser Val Asp His Val Lys 
        915                 920                 925             


Asn Ile Glu Asn Leu His Gly Ser Arg Leu Asn Asp Arg Ile Ala Gly 
    930                 935                 940                 


Asp Asp Gln Asp Asn Glu Leu Trp Gly His Asp Gly Asn Asp Thr Ile 
945                 950                 955                 960 


Arg Gly Arg Gly Gly Asp Asp Ile Leu Arg Gly Gly Leu Gly Leu Asp 
                965                 970                 975     


Thr Leu Tyr Gly Glu Asp Gly Asn Asp Ile Phe Leu Gln Asp Asp Glu 
            980                 985                 990         


Thr Val Ser Asp Asp Ile Asp Gly  Gly Ala Gly Leu Asp  Thr Val Asp 
        995                 1000                 1005             


Tyr Ser  Ala Met Ile His Pro  Gly Arg Ile Val Ala  Pro His Glu 
    1010                 1015                 1020             


Tyr Gly  Phe Gly Ile Glu Ala  Asp Leu Ser Arg Glu  Trp Val Arg 
    1025                 1030                 1035             


Lys Ala  Ser Ala Leu Gly Val  Asp Tyr Tyr Asp Asn  Val Arg Asn 
    1040                 1045                 1050             


Val Glu  Asn Val Ile Gly Thr  Ser Met Lys Asp Val  Leu Ile Gly 
    1055                 1060                 1065             


Asp Ala  Gln Ala Asn Thr Leu  Met Gly Gln Gly Gly  Asp Asp Thr 
    1070                 1075                 1080             


Val Arg  Gly Gly Asp Gly Asp  Asp Leu Leu Phe Gly  Gly Asp Gly 
    1085                 1090                 1095             


Asn Asp  Met Leu Tyr Gly Asp  Ala Gly Asn Asp Thr  Leu Tyr Gly 
    1100                 1105                 1110             


Gly Leu  Gly Asp Asp Thr Leu  Glu Gly Gly Ala Gly  Asn Asp Trp 
    1115                 1120                 1125             


Phe Gly  Gln Thr Gln Ala Arg  Glu His Asp Val Leu  Arg Gly Gly 
    1130                 1135                 1140             


Asp Gly  Val Asp Thr Val Asp  Tyr Ser Gln Thr Gly  Ala His Ala 
    1145                 1150                 1155             


Gly Ile  Ala Ala Gly Arg Ile  Gly Leu Gly Ile Leu  Ala Asp Leu 
    1160                 1165                 1170             


Gly Ala  Gly Arg Val Asp Lys  Leu Gly Glu Ala Gly  Ser Ser Ala 
    1175                 1180                 1185             


Tyr Asp  Thr Val Ser Gly Ile  Glu Asn Val Val Gly  Thr Glu Leu 
    1190                 1195                 1200             


Ala Asp  Arg Ile Thr Gly Asp  Ala Gln Ala Asn Val  Leu Arg Gly 
    1205                 1210                 1215             


Ala Gly  Gly Ala Asp Val Leu  Ala Gly Gly Glu Gly  Asp Asp Val 
    1220                 1225                 1230             


Leu Leu  Gly Gly Asp Gly Asp  Asp Gln Leu Ser Gly  Asp Ala Gly 
    1235                 1240                 1245             


Arg Asp  Arg Leu Tyr Gly Glu  Ala Gly Asp Asp Trp  Phe Phe Gln 
    1250                 1255                 1260             


Asp Ala  Ala Asn Ala Gly Asn  Leu Leu Asp Gly Gly  Asp Gly Arg 
    1265                 1270                 1275             


Asp Thr  Val Asp Phe Ser Gly  Pro Gly Arg Gly Leu  Asp Ala Gly 
    1280                 1285                 1290             


Ala Lys  Gly Val Phe Leu Ser  Leu Gly Lys Gly Phe  Ala Ser Leu 
    1295                 1300                 1305             


Met Asp  Glu Pro Glu Thr Ser  Asn Val Leu Arg Asn  Ile Glu Asn 
    1310                 1315                 1320             


Ala Val  Gly Ser Ala Arg Asp  Asp Val Leu Ile Gly  Asp Ala Gly 
    1325                 1330                 1335             


Ala Asn  Val Leu Asn Gly Leu  Ala Gly Asn Asp Val  Leu Ser Gly 
    1340                 1345                 1350             


Gly Ala  Gly Asp Asp Val Leu  Leu Gly Asp Glu Gly  Ser Asp Leu 
    1355                 1360                 1365             


Leu Ser  Gly Asp Ala Gly Asn  Asp Asp Leu Phe Gly  Gly Gln Gly 
    1370                 1375                 1380             


Asp Asp  Thr Tyr Leu Phe Gly  Val Gly Tyr Gly His  Asp Thr Ile 
    1385                 1390                 1395             


Tyr Glu  Ser Gly Gly Gly His  Asp Thr Ile Arg Ile  Asn Ala Gly 
    1400                 1405                 1410             


Ala Asp  Gln Leu Trp Phe Ala  Arg Gln Gly Asn Asp  Leu Glu Ile 
    1415                 1420                 1425             


Arg Ile  Leu Gly Thr Asp Asp  Ala Leu Thr Val His  Asp Trp Tyr 
    1430                 1435                 1440             


Arg Asp  Ala Asp His Arg Val  Glu Ile Ile His Ala  Ala Asn Gln 
    1445                 1450                 1455             


Ala Val  Asp Gln Ala Gly Ile  Glu Lys Leu Val Glu  Ala Met Ala 
    1460                 1465                 1470             


Gln Tyr  Pro Asp Pro Gly Ala  Ala Ala Ala Ala Pro  Pro Ala Ala 
    1475                 1480                 1485             


Arg Val  Pro Asp Thr Leu Met  Gln Ser Leu Ala Val  Asn Trp Arg 
    1490                 1495                 1500             


<210>  72
<211>  4842
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding polypeptide 1-227 + 321-1706 of CyaA


<220>
<221>  CDS
<222>  (1)..(4842)

<400>  72
atg cag cag tcc cat cag gcc ggt tac gca aac gca gcc gat cgt gaa         48
Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu           
1               5                   10                  15                

tct ggt atc ccg gca gcg gtt ctg gat ggt att aag gca gtt gcc aaa         96
Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys           
            20                  25                  30                    

gag aag aac gct acc ctg atg ttc cgt ctg gtc aac cca cac tct act        144
Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr           
        35                  40                  45                        

tcc ctg atc gcg gaa ggt gtg gcg acc aaa ggc ctg ggt gtg cac gcc        192
Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala           
    50                  55                  60                            

aaa agc agc gac tgg ggt ctg cag gca ggt tat att ccg gtg aac ccg        240
Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro           
65                  70                  75                  80            

aat ctg tct aaa ctg ttc ggt cgt gcc ccg gag gtg atc gca cgt gca        288
Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala           
                85                  90                  95                

gac aac gat gtc aac tct tct ctg gcg cat ggt cac acc gcg gtt gat        336
Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp           
            100                 105                 110                   

ctg acc ctg tcc aaa gaa cgc ctg gat tac ctg cgt cag gcg ggc ctg        384
Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu           
        115                 120                 125                       

gtg acg ggc atg gcc gac ggt gtt gta gcg agc aac cac gcg ggt tat        432
Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr           
    130                 135                 140                           

gaa caa ttt gag ttt cgc gtt aaa gag acc tct gac ggt cgt tac gcg        480
Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala           
145                 150                 155                 160           

gtg cag tac cgc cgc aaa ggt ggc gat gac ttt gaa gct gtc aaa gtg        528
Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val           
                165                 170                 175               

atc ggt aac gct gct gga att ccg ctg acc gcg gat atc gac atg ttt        576
Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Ile Asp Met Phe           
            180                 185                 190                   

gcc atc atg cct cac ctg tcc aac ttt cgc gat tcc gca cgc agc tct        624
Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg Ser Ser           
        195                 200                 205                       

gtg acg tct ggt gat tcc gtc act gac tac ctg gct cgt acc cgt cgt        672
Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr Arg Arg           
    210                 215                 220                           

gcg gcc tct gaa tcc cag atg ctg act cgt ggc cag ctg aaa gaa tac        720
Ala Ala Ser Glu Ser Gln Met Leu Thr Arg Gly Gln Leu Lys Glu Tyr           
225                 230                 235                 240           

atc ggc caa cag cgt ggc gaa ggc tac gtt ttc tac gag aat cgt gct        768
Ile Gly Gln Gln Arg Gly Glu Gly Tyr Val Phe Tyr Glu Asn Arg Ala           
                245                 250                 255               

tac ggc gtt gcg ggc aaa tcc ctg ttc gac gat ggt ctg ggc gct gca        816
Tyr Gly Val Ala Gly Lys Ser Leu Phe Asp Asp Gly Leu Gly Ala Ala           
            260                 265                 270                   

ccg ggc gtt ccg agc ggc cgt tct aaa ttc agc ccg gac gta ctg gaa        864
Pro Gly Val Pro Ser Gly Arg Ser Lys Phe Ser Pro Asp Val Leu Glu           
        275                 280                 285                       

act gtg ccg gct tcc ccg ggc ctg cgc cgt ccg tcc ctg ggc gca gtc        912
Thr Val Pro Ala Ser Pro Gly Leu Arg Arg Pro Ser Leu Gly Ala Val           
    290                 295                 300                           

gaa cgt cag gac tcc ggc tac gat tcc ctg gat ggc gtt ggc tcc cgc        960
Glu Arg Gln Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly Ser Arg           
305                 310                 315                 320           

tcc ttc tcc ctg ggc gag gtt tct gac atg gct gcg gtg gaa gcg gca       1008
Ser Phe Ser Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu Ala Ala           
                325                 330                 335               

gag ctg gaa atg acc cgt caa gtg ctg cac gcg ggc gca cgt cag gac       1056
Glu Leu Glu Met Thr Arg Gln Val Leu His Ala Gly Ala Arg Gln Asp           
            340                 345                 350                   

gat gct gag ccg ggc gtg tcc ggt gcg tct gca cac tgg ggt caa cgt       1104
Asp Ala Glu Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly Gln Arg           
        355                 360                 365                       

gcc ctg cag ggt gct caa gct gtc gcg gca gcg cag cgt ctg gta cat       1152
Ala Leu Gln Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu Val His           
    370                 375                 380                           

gcg atc gca ctg atg acc cag ttc ggt cgc gca ggt tct acc aac act       1200
Ala Ile Ala Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr Asn Thr           
385                 390                 395                 400           

cct cag gaa gca gct agc ctg tct gct gct gtt ttc ggt ctg ggc gaa       1248
Pro Gln Glu Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu Gly Glu           
                405                 410                 415               

gcg tct tct gcg gtt gca gaa acc gtg agc ggt ttc ttc cgt ggt tct       1296
Ala Ser Ser Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg Gly Ser           
            420                 425                 430                   

agc cgc tgg gcg ggt ggt ttt ggt gta gca ggt ggc gct atg gcc ctg       1344
Ser Arg Trp Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met Ala Leu           
        435                 440                 445                       

ggt ggc ggt atc gcg gct gct gtc ggc gca ggt atg agc ctg acc gac       1392
Gly Gly Gly Ile Ala Ala Ala Val Gly Ala Gly Met Ser Leu Thr Asp           
    450                 455                 460                           

gat gct cct gcg ggc cag aaa gcc gca gct ggc gct gaa atc gcg ctg       1440
Asp Ala Pro Ala Gly Gln Lys Ala Ala Ala Gly Ala Glu Ile Ala Leu           
465                 470                 475                 480           

cag ctg act ggt ggt acc gtt gaa ctg gct agc tct atc gcg ctg gct       1488
Gln Leu Thr Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala Leu Ala           
                485                 490                 495               

ctg gca gcg gca cgt ggc gtg act tct ggc ctg caa gtc gcc ggt gcc       1536
Leu Ala Ala Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala Gly Ala           
            500                 505                 510                   

tct gcg ggc gct gct gcg ggc gct ctg gca gct gca ctg tcc ccc atg       1584
Ser Ala Gly Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser Pro Met           
        515                 520                 525                       

gaa atc tac ggt ctg gta cag cag tct cac tac gca gac cag ctg gat       1632
Glu Ile Tyr Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln Leu Asp           
    530                 535                 540                           

aaa ctg gcg cag gag tct tct gca tac ggt tac gaa ggc gac gca ctg       1680
Lys Leu Ala Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp Ala Leu           
545                 550                 555                 560           

ctg gcg cag ctg tat cgt gac aaa act gct gct gaa ggt gct gtg gca       1728
Leu Ala Gln Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala Val Ala           
                565                 570                 575               

ggc gtt tct gcg gta ctg tct acc gtt ggc gct gcg gtt tct att gcg       1776
Gly Val Ser Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser Ile Ala           
            580                 585                 590                   

gct gcc gca tcc gtt gta ggt gcg ccg gtt gct gta gtt acc tct ctg       1824
Ala Ala Ala Ser Val Val Gly Ala Pro Val Ala Val Val Thr Ser Leu           
        595                 600                 605                       

ctg act ggt gca ctg aac ggt atc ctg cgt ggt gtt cag cag cct att       1872
Leu Thr Gly Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln Pro Ile           
    610                 615                 620                           

atc gaa aaa ctg gcg aat gat tat gcc cgt aaa atc gac gaa ctg ggc       1920
Ile Glu Lys Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu Leu Gly           
625                 630                 635                 640           

ggt ccg cag gct tat ttt gaa aaa aac ctg cag gcg cgc cac gaa cag       1968
Gly Pro Gln Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His Glu Gln           
                645                 650                 655               

ctg gca aac agc gac ggc ctg cgc aaa atg ctg gca gac ctg caa gct       2016
Leu Ala Asn Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu Gln Ala           
            660                 665                 670                   

ggt tgg aac gcg tct tct gtg atc ggc gtg cag acc acc gaa att agc       2064
Gly Trp Asn Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu Ile Ser           
        675                 680                 685                       

aaa tct gcg ctg gaa ctg gct gca att act ggc aac gcg gat aac ctg       2112
Lys Ser Ala Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp Asn Leu           
    690                 695                 700                           

aaa agc gtt gat gtt ttt gtc gat cgc ttc gtt cag ggc gag cgc gtt       2160
Lys Ser Val Asp Val Phe Val Asp Arg Phe Val Gln Gly Glu Arg Val           
705                 710                 715                 720           

gct ggt cag ccg gtt gtt ctg gac gtt gcg gca ggc ggc atc gac atc       2208
Ala Gly Gln Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile Asp Ile           
                725                 730                 735               

gct agc cgc aag ggc gag cgt ccg gct ctg act ttc att acc ccg ctg       2256
Ala Ser Arg Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr Pro Leu           
            740                 745                 750                   

gca gct ccg ggt gaa gaa cag cgt cgc cgt acc aag act ggt aaa agc       2304
Ala Ala Pro Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly Lys Ser           
        755                 760                 765                       

gag ttc acc acc ttc gtg gaa atc gta ggt aaa cag gac cgc tgg cgt       2352
Glu Phe Thr Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg Trp Arg           
    770                 775                 780                           

att cgc gac ggt gcg gcg gac acc acc atc gac ctg gca aaa gtt gtt       2400
Ile Arg Asp Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys Val Val           
785                 790                 795                 800           

tcc caa ctg gta gat gct aac ggc gtg ctg aaa cat tct att aaa ctg       2448
Ser Gln Leu Val Asp Ala Asn Gly Val Leu Lys His Ser Ile Lys Leu           
                805                 810                 815               

gat gta atc ggc ggt gac ggc gat gac gtt gta ctg gcg aac gcg tct       2496
Asp Val Ile Gly Gly Asp Gly Asp Asp Val Val Leu Ala Asn Ala Ser           
            820                 825                 830                   

cgt atc cac tat gac ggc ggc gca ggt acc aac acg gtt tcc tac gca       2544
Arg Ile His Tyr Asp Gly Gly Ala Gly Thr Asn Thr Val Ser Tyr Ala           
        835                 840                 845                       

gcg ctg ggc cgc cag gat tcc atc act gtt agc gcc gat ggc gaa cgt       2592
Ala Leu Gly Arg Gln Asp Ser Ile Thr Val Ser Ala Asp Gly Glu Arg           
    850                 855                 860                           

ttc aac gtg cgt aaa cag ctg aat aac gca aac gtc tat cgt gag ggt       2640
Phe Asn Val Arg Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg Glu Gly           
865                 870                 875                 880           

gta gct acc cag acc acc gcg tac ggt aag cgt acc gaa aac gtt cag       2688
Val Ala Thr Gln Thr Thr Ala Tyr Gly Lys Arg Thr Glu Asn Val Gln           
                885                 890                 895               

tat cgt cac gtg gaa ctg gca cgt gtg ggt cag ctg gta gag gtg gat       2736
Tyr Arg His Val Glu Leu Ala Arg Val Gly Gln Leu Val Glu Val Asp           
            900                 905                 910                   

acg ctg gaa cac gtg cag cac atc atc ggt ggc gcc ggt aac gat tcc       2784
Thr Leu Glu His Val Gln His Ile Ile Gly Gly Ala Gly Asn Asp Ser           
        915                 920                 925                       

att act ggt aac gct cac gac aac ttc ctg gca ggt ggt tct ggt gat       2832
Ile Thr Gly Asn Ala His Asp Asn Phe Leu Ala Gly Gly Ser Gly Asp           
    930                 935                 940                           

gat cgt ctg gac ggt ggt gcg ggt aac gat acg ctg gta ggc ggc gaa       2880
Asp Arg Leu Asp Gly Gly Ala Gly Asn Asp Thr Leu Val Gly Gly Glu           
945                 950                 955                 960           

ggt cag aac acc gta att ggt ggt gcc ggt gac gac gtt ttc ctg cag       2928
Gly Gln Asn Thr Val Ile Gly Gly Ala Gly Asp Asp Val Phe Leu Gln           
                965                 970                 975               

gat ctg ggc gtt tgg agc aac cag ctg gat ggc ggt gcc ggt gtt gac       2976
Asp Leu Gly Val Trp Ser Asn Gln Leu Asp Gly Gly Ala Gly Val Asp           
            980                 985                 990                   

acg gtt aag tat aac gtt cac cag  ccg tct gaa gag cgc  ctg gaa cgt     3024
Thr Val Lys Tyr Asn Val His Gln  Pro Ser Glu Glu Arg  Leu Glu Arg         
        995                 1000                 1005                     

atg ggt  gac act ggt att cat  gcc gat ctg cag aaa  ggc act gtt        3069
Met Gly  Asp Thr Gly Ile His  Ala Asp Leu Gln Lys  Gly Thr Val            
    1010                 1015                 1020                        

gaa aaa  tgg cct gcg ctg aac  ctg ttc tct gtg gac  cat gtt aag        3114
Glu Lys  Trp Pro Ala Leu Asn  Leu Phe Ser Val Asp  His Val Lys            
    1025                 1030                 1035                        

aac att  gaa aac ctg cat ggc  tct cgc ctg aac gac  cgt atc gct        3159
Asn Ile  Glu Asn Leu His Gly  Ser Arg Leu Asn Asp  Arg Ile Ala            
    1040                 1045                 1050                        

ggt gac  gac cag gat aac gaa  ctg tgg ggt cat gac  ggc aat gat        3204
Gly Asp  Asp Gln Asp Asn Glu  Leu Trp Gly His Asp  Gly Asn Asp            
    1055                 1060                 1065                        

acc att  cgc ggt cgt ggc ggc  gac gat att ctg cgt  ggc ggt ctg        3249
Thr Ile  Arg Gly Arg Gly Gly  Asp Asp Ile Leu Arg  Gly Gly Leu            
    1070                 1075                 1080                        

ggc ctg  gat acc ctg tat ggt  gaa gat ggt aac gat  att ttc ctg        3294
Gly Leu  Asp Thr Leu Tyr Gly  Glu Asp Gly Asn Asp  Ile Phe Leu            
    1085                 1090                 1095                        

caa gac  gat gaa acg gta tct  gat gac atc gac ggt  ggt gca ggc        3339
Gln Asp  Asp Glu Thr Val Ser  Asp Asp Ile Asp Gly  Gly Ala Gly            
    1100                 1105                 1110                        

ctg gac  acc gta gat tac agc  gct atg atc cat ccg  ggt cgt atc        3384
Leu Asp  Thr Val Asp Tyr Ser  Ala Met Ile His Pro  Gly Arg Ile            
    1115                 1120                 1125                        

gta gct  ccg cac gag tac ggc  ttc ggt atc gag gcg  gac ctg tct        3429
Val Ala  Pro His Glu Tyr Gly  Phe Gly Ile Glu Ala  Asp Leu Ser            
    1130                 1135                 1140                        

cgt gaa  tgg gtt cgt aaa gcg  tcc gcg ctg ggt gtg  gac tac tac        3474
Arg Glu  Trp Val Arg Lys Ala  Ser Ala Leu Gly Val  Asp Tyr Tyr            
    1145                 1150                 1155                        

gat aac  gtt cgt aac gtg gaa  aac gtg atc ggt acc  tcc atg aaa        3519
Asp Asn  Val Arg Asn Val Glu  Asn Val Ile Gly Thr  Ser Met Lys            
    1160                 1165                 1170                        

gac gtg  ctg att ggc gac gca  cag gcc aac act ctg  atg ggc cag        3564
Asp Val  Leu Ile Gly Asp Ala  Gln Ala Asn Thr Leu  Met Gly Gln            
    1175                 1180                 1185                        

ggc ggt  gat gac acg gtt cgc  ggc ggc gac ggt gat  gac ctg ctg        3609
Gly Gly  Asp Asp Thr Val Arg  Gly Gly Asp Gly Asp  Asp Leu Leu            
    1190                 1195                 1200                        

ttc ggt  ggt gac ggc aac gac  atg ctg tac ggc gac  gcg ggc aac        3654
Phe Gly  Gly Asp Gly Asn Asp  Met Leu Tyr Gly Asp  Ala Gly Asn            
    1205                 1210                 1215                        

gac acc  ctg tac ggc ggt ctg  ggt gac gac act ctg  gaa ggt ggt        3699
Asp Thr  Leu Tyr Gly Gly Leu  Gly Asp Asp Thr Leu  Glu Gly Gly            
    1220                 1225                 1230                        

gca ggt  aac gac tgg ttc ggc  caa acc cag gca cgc  gaa cac gac        3744
Ala Gly  Asn Asp Trp Phe Gly  Gln Thr Gln Ala Arg  Glu His Asp            
    1235                 1240                 1245                        

gtg ctg  cgt ggt ggc gac ggc  gta gac acc gtg gat  tac tcc caa        3789
Val Leu  Arg Gly Gly Asp Gly  Val Asp Thr Val Asp  Tyr Ser Gln            
    1250                 1255                 1260                        

act ggc  gct cac gcg ggt atc  gcg gcc ggt cgt atc  ggt ctg ggc        3834
Thr Gly  Ala His Ala Gly Ile  Ala Ala Gly Arg Ile  Gly Leu Gly            
    1265                 1270                 1275                        

att ctg  gcc gat ctg ggt gcc  ggc cgt gtc gac aaa  ctg ggt gag        3879
Ile Leu  Ala Asp Leu Gly Ala  Gly Arg Val Asp Lys  Leu Gly Glu            
    1280                 1285                 1290                        

gct ggc  tct agc gcc tat gat  act gtt tcc ggc atc  gaa aac gtg        3924
Ala Gly  Ser Ser Ala Tyr Asp  Thr Val Ser Gly Ile  Glu Asn Val            
    1295                 1300                 1305                        

gta ggc  act gaa ctg gca gat  cgt atc acg ggt gac  gcg caa gcg        3969
Val Gly  Thr Glu Leu Ala Asp  Arg Ile Thr Gly Asp  Ala Gln Ala            
    1310                 1315                 1320                        

aac gtt  ctg cgt ggt gct ggc  ggt gca gac gtg ctg  gcg ggt ggt        4014
Asn Val  Leu Arg Gly Ala Gly  Gly Ala Asp Val Leu  Ala Gly Gly            
    1325                 1330                 1335                        

gaa ggc  gac gac gta ctg ctg  ggc ggt gac ggt gac  gat cag ctg        4059
Glu Gly  Asp Asp Val Leu Leu  Gly Gly Asp Gly Asp  Asp Gln Leu            
    1340                 1345                 1350                        

agc ggt  gat gcg ggt cgt gac  cgt ctg tac ggt gaa  gca ggt gac        4104
Ser Gly  Asp Ala Gly Arg Asp  Arg Leu Tyr Gly Glu  Ala Gly Asp            
    1355                 1360                 1365                        

gat tgg  ttc ttc cag gac gct  gct aac gct ggc aac  ctg ctg gac        4149
Asp Trp  Phe Phe Gln Asp Ala  Ala Asn Ala Gly Asn  Leu Leu Asp            
    1370                 1375                 1380                        

ggc ggc  gat ggc cgt gac act  gtt gac ttc agc ggt  ccg ggt cgc        4194
Gly Gly  Asp Gly Arg Asp Thr  Val Asp Phe Ser Gly  Pro Gly Arg            
    1385                 1390                 1395                        

ggt ctg  gac gca ggc gcg aaa  ggc gtt ttc ctg agc  ctg ggt aag        4239
Gly Leu  Asp Ala Gly Ala Lys  Gly Val Phe Leu Ser  Leu Gly Lys            
    1400                 1405                 1410                        

ggt ttc  gca tct ctg atg gac  gaa cca gaa acc agc  aat gtc ctg        4284
Gly Phe  Ala Ser Leu Met Asp  Glu Pro Glu Thr Ser  Asn Val Leu            
    1415                 1420                 1425                        

cgt aac  atc gaa aac gct gtc  ggt tcc gca cgc gat  gat gtt ctg        4329
Arg Asn  Ile Glu Asn Ala Val  Gly Ser Ala Arg Asp  Asp Val Leu            
    1430                 1435                 1440                        

att ggc  gat gct ggt gcc aat  gtt ctg aac ggt ctg  gcg ggt aat        4374
Ile Gly  Asp Ala Gly Ala Asn  Val Leu Asn Gly Leu  Ala Gly Asn            
    1445                 1450                 1455                        

gat gta  ctg tct ggt ggc gct  ggt gat gat gtc ctg  ctg ggt gat        4419
Asp Val  Leu Ser Gly Gly Ala  Gly Asp Asp Val Leu  Leu Gly Asp            
    1460                 1465                 1470                        

gag ggc  agc gat ctg ctg tcc  ggc gat gcc ggc aac  gac gat ctg        4464
Glu Gly  Ser Asp Leu Leu Ser  Gly Asp Ala Gly Asn  Asp Asp Leu            
    1475                 1480                 1485                        

ttc ggt  ggc caa ggt gat gat  act tac ctg ttc ggc  gtt ggc tat        4509
Phe Gly  Gly Gln Gly Asp Asp  Thr Tyr Leu Phe Gly  Val Gly Tyr            
    1490                 1495                 1500                        

ggt cat  gac acc atc tat gag  tct ggt ggc ggc cac  gat acg att        4554
Gly His  Asp Thr Ile Tyr Glu  Ser Gly Gly Gly His  Asp Thr Ile            
    1505                 1510                 1515                        

cgt att  aat gca ggt gct gac  caa ctg tgg ttt gca  cgt cag ggt        4599
Arg Ile  Asn Ala Gly Ala Asp  Gln Leu Trp Phe Ala  Arg Gln Gly            
    1520                 1525                 1530                        

aac gat  ctg gaa att cgc atc  ctg ggt act gat gac  gct ctg acc        4644
Asn Asp  Leu Glu Ile Arg Ile  Leu Gly Thr Asp Asp  Ala Leu Thr            
    1535                 1540                 1545                        

gta cac  gac tgg tac cgc gat  gcg gat cac cgc gta  gaa atc atc        4689
Val His  Asp Trp Tyr Arg Asp  Ala Asp His Arg Val  Glu Ile Ile            
    1550                 1555                 1560                        

cat gcg  gct aac caa gct gta  gac cag gct ggt att  gaa aaa ctg        4734
His Ala  Ala Asn Gln Ala Val  Asp Gln Ala Gly Ile  Glu Lys Leu            
    1565                 1570                 1575                        

gta gaa  gcg atg gca cag tat  ccg gac cca ggt gcg  gct gct gca        4779
Val Glu  Ala Met Ala Gln Tyr  Pro Asp Pro Gly Ala  Ala Ala Ala            
    1580                 1585                 1590                        

gca cct  cca gcg gct cgt gtg  ccg gat acc ctg atg  cag agc ctg        4824
Ala Pro  Pro Ala Ala Arg Val  Pro Asp Thr Leu Met  Gln Ser Leu            
    1595                 1600                 1605                        

gcc gtc  aat tgg cgt taa                                              4842
Ala Val  Asn Trp Arg                                                      
    1610                                                                  


<210>  73
<211>  1613
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  73

Met Gln Gln Ser His Gln Ala Gly Tyr Ala Asn Ala Ala Asp Arg Glu 
1               5                   10                  15      


Ser Gly Ile Pro Ala Ala Val Leu Asp Gly Ile Lys Ala Val Ala Lys 
            20                  25                  30          


Glu Lys Asn Ala Thr Leu Met Phe Arg Leu Val Asn Pro His Ser Thr 
        35                  40                  45              


Ser Leu Ile Ala Glu Gly Val Ala Thr Lys Gly Leu Gly Val His Ala 
    50                  55                  60                  


Lys Ser Ser Asp Trp Gly Leu Gln Ala Gly Tyr Ile Pro Val Asn Pro 
65                  70                  75                  80  


Asn Leu Ser Lys Leu Phe Gly Arg Ala Pro Glu Val Ile Ala Arg Ala 
                85                  90                  95      


Asp Asn Asp Val Asn Ser Ser Leu Ala His Gly His Thr Ala Val Asp 
            100                 105                 110         


Leu Thr Leu Ser Lys Glu Arg Leu Asp Tyr Leu Arg Gln Ala Gly Leu 
        115                 120                 125             


Val Thr Gly Met Ala Asp Gly Val Val Ala Ser Asn His Ala Gly Tyr 
    130                 135                 140                 


Glu Gln Phe Glu Phe Arg Val Lys Glu Thr Ser Asp Gly Arg Tyr Ala 
145                 150                 155                 160 


Val Gln Tyr Arg Arg Lys Gly Gly Asp Asp Phe Glu Ala Val Lys Val 
                165                 170                 175     


Ile Gly Asn Ala Ala Gly Ile Pro Leu Thr Ala Asp Ile Asp Met Phe 
            180                 185                 190         


Ala Ile Met Pro His Leu Ser Asn Phe Arg Asp Ser Ala Arg Ser Ser 
        195                 200                 205             


Val Thr Ser Gly Asp Ser Val Thr Asp Tyr Leu Ala Arg Thr Arg Arg 
    210                 215                 220                 


Ala Ala Ser Glu Ser Gln Met Leu Thr Arg Gly Gln Leu Lys Glu Tyr 
225                 230                 235                 240 


Ile Gly Gln Gln Arg Gly Glu Gly Tyr Val Phe Tyr Glu Asn Arg Ala 
                245                 250                 255     


Tyr Gly Val Ala Gly Lys Ser Leu Phe Asp Asp Gly Leu Gly Ala Ala 
            260                 265                 270         


Pro Gly Val Pro Ser Gly Arg Ser Lys Phe Ser Pro Asp Val Leu Glu 
        275                 280                 285             


Thr Val Pro Ala Ser Pro Gly Leu Arg Arg Pro Ser Leu Gly Ala Val 
    290                 295                 300                 


Glu Arg Gln Asp Ser Gly Tyr Asp Ser Leu Asp Gly Val Gly Ser Arg 
305                 310                 315                 320 


Ser Phe Ser Leu Gly Glu Val Ser Asp Met Ala Ala Val Glu Ala Ala 
                325                 330                 335     


Glu Leu Glu Met Thr Arg Gln Val Leu His Ala Gly Ala Arg Gln Asp 
            340                 345                 350         


Asp Ala Glu Pro Gly Val Ser Gly Ala Ser Ala His Trp Gly Gln Arg 
        355                 360                 365             


Ala Leu Gln Gly Ala Gln Ala Val Ala Ala Ala Gln Arg Leu Val His 
    370                 375                 380                 


Ala Ile Ala Leu Met Thr Gln Phe Gly Arg Ala Gly Ser Thr Asn Thr 
385                 390                 395                 400 


Pro Gln Glu Ala Ala Ser Leu Ser Ala Ala Val Phe Gly Leu Gly Glu 
                405                 410                 415     


Ala Ser Ser Ala Val Ala Glu Thr Val Ser Gly Phe Phe Arg Gly Ser 
            420                 425                 430         


Ser Arg Trp Ala Gly Gly Phe Gly Val Ala Gly Gly Ala Met Ala Leu 
        435                 440                 445             


Gly Gly Gly Ile Ala Ala Ala Val Gly Ala Gly Met Ser Leu Thr Asp 
    450                 455                 460                 


Asp Ala Pro Ala Gly Gln Lys Ala Ala Ala Gly Ala Glu Ile Ala Leu 
465                 470                 475                 480 


Gln Leu Thr Gly Gly Thr Val Glu Leu Ala Ser Ser Ile Ala Leu Ala 
                485                 490                 495     


Leu Ala Ala Ala Arg Gly Val Thr Ser Gly Leu Gln Val Ala Gly Ala 
            500                 505                 510         


Ser Ala Gly Ala Ala Ala Gly Ala Leu Ala Ala Ala Leu Ser Pro Met 
        515                 520                 525             


Glu Ile Tyr Gly Leu Val Gln Gln Ser His Tyr Ala Asp Gln Leu Asp 
    530                 535                 540                 


Lys Leu Ala Gln Glu Ser Ser Ala Tyr Gly Tyr Glu Gly Asp Ala Leu 
545                 550                 555                 560 


Leu Ala Gln Leu Tyr Arg Asp Lys Thr Ala Ala Glu Gly Ala Val Ala 
                565                 570                 575     


Gly Val Ser Ala Val Leu Ser Thr Val Gly Ala Ala Val Ser Ile Ala 
            580                 585                 590         


Ala Ala Ala Ser Val Val Gly Ala Pro Val Ala Val Val Thr Ser Leu 
        595                 600                 605             


Leu Thr Gly Ala Leu Asn Gly Ile Leu Arg Gly Val Gln Gln Pro Ile 
    610                 615                 620                 


Ile Glu Lys Leu Ala Asn Asp Tyr Ala Arg Lys Ile Asp Glu Leu Gly 
625                 630                 635                 640 


Gly Pro Gln Ala Tyr Phe Glu Lys Asn Leu Gln Ala Arg His Glu Gln 
                645                 650                 655     


Leu Ala Asn Ser Asp Gly Leu Arg Lys Met Leu Ala Asp Leu Gln Ala 
            660                 665                 670         


Gly Trp Asn Ala Ser Ser Val Ile Gly Val Gln Thr Thr Glu Ile Ser 
        675                 680                 685             


Lys Ser Ala Leu Glu Leu Ala Ala Ile Thr Gly Asn Ala Asp Asn Leu 
    690                 695                 700                 


Lys Ser Val Asp Val Phe Val Asp Arg Phe Val Gln Gly Glu Arg Val 
705                 710                 715                 720 


Ala Gly Gln Pro Val Val Leu Asp Val Ala Ala Gly Gly Ile Asp Ile 
                725                 730                 735     


Ala Ser Arg Lys Gly Glu Arg Pro Ala Leu Thr Phe Ile Thr Pro Leu 
            740                 745                 750         


Ala Ala Pro Gly Glu Glu Gln Arg Arg Arg Thr Lys Thr Gly Lys Ser 
        755                 760                 765             


Glu Phe Thr Thr Phe Val Glu Ile Val Gly Lys Gln Asp Arg Trp Arg 
    770                 775                 780                 


Ile Arg Asp Gly Ala Ala Asp Thr Thr Ile Asp Leu Ala Lys Val Val 
785                 790                 795                 800 


Ser Gln Leu Val Asp Ala Asn Gly Val Leu Lys His Ser Ile Lys Leu 
                805                 810                 815     


Asp Val Ile Gly Gly Asp Gly Asp Asp Val Val Leu Ala Asn Ala Ser 
            820                 825                 830         


Arg Ile His Tyr Asp Gly Gly Ala Gly Thr Asn Thr Val Ser Tyr Ala 
        835                 840                 845             


Ala Leu Gly Arg Gln Asp Ser Ile Thr Val Ser Ala Asp Gly Glu Arg 
    850                 855                 860                 


Phe Asn Val Arg Lys Gln Leu Asn Asn Ala Asn Val Tyr Arg Glu Gly 
865                 870                 875                 880 


Val Ala Thr Gln Thr Thr Ala Tyr Gly Lys Arg Thr Glu Asn Val Gln 
                885                 890                 895     


Tyr Arg His Val Glu Leu Ala Arg Val Gly Gln Leu Val Glu Val Asp 
            900                 905                 910         


Thr Leu Glu His Val Gln His Ile Ile Gly Gly Ala Gly Asn Asp Ser 
        915                 920                 925             


Ile Thr Gly Asn Ala His Asp Asn Phe Leu Ala Gly Gly Ser Gly Asp 
    930                 935                 940                 


Asp Arg Leu Asp Gly Gly Ala Gly Asn Asp Thr Leu Val Gly Gly Glu 
945                 950                 955                 960 


Gly Gln Asn Thr Val Ile Gly Gly Ala Gly Asp Asp Val Phe Leu Gln 
                965                 970                 975     


Asp Leu Gly Val Trp Ser Asn Gln Leu Asp Gly Gly Ala Gly Val Asp 
            980                 985                 990         


Thr Val Lys Tyr Asn Val His Gln  Pro Ser Glu Glu Arg  Leu Glu Arg 
        995                 1000                 1005             


Met Gly  Asp Thr Gly Ile His  Ala Asp Leu Gln Lys  Gly Thr Val 
    1010                 1015                 1020             


Glu Lys  Trp Pro Ala Leu Asn  Leu Phe Ser Val Asp  His Val Lys 
    1025                 1030                 1035             


Asn Ile  Glu Asn Leu His Gly  Ser Arg Leu Asn Asp  Arg Ile Ala 
    1040                 1045                 1050             


Gly Asp  Asp Gln Asp Asn Glu  Leu Trp Gly His Asp  Gly Asn Asp 
    1055                 1060                 1065             


Thr Ile  Arg Gly Arg Gly Gly  Asp Asp Ile Leu Arg  Gly Gly Leu 
    1070                 1075                 1080             


Gly Leu  Asp Thr Leu Tyr Gly  Glu Asp Gly Asn Asp  Ile Phe Leu 
    1085                 1090                 1095             


Gln Asp  Asp Glu Thr Val Ser  Asp Asp Ile Asp Gly  Gly Ala Gly 
    1100                 1105                 1110             


Leu Asp  Thr Val Asp Tyr Ser  Ala Met Ile His Pro  Gly Arg Ile 
    1115                 1120                 1125             


Val Ala  Pro His Glu Tyr Gly  Phe Gly Ile Glu Ala  Asp Leu Ser 
    1130                 1135                 1140             


Arg Glu  Trp Val Arg Lys Ala  Ser Ala Leu Gly Val  Asp Tyr Tyr 
    1145                 1150                 1155             


Asp Asn  Val Arg Asn Val Glu  Asn Val Ile Gly Thr  Ser Met Lys 
    1160                 1165                 1170             


Asp Val  Leu Ile Gly Asp Ala  Gln Ala Asn Thr Leu  Met Gly Gln 
    1175                 1180                 1185             


Gly Gly  Asp Asp Thr Val Arg  Gly Gly Asp Gly Asp  Asp Leu Leu 
    1190                 1195                 1200             


Phe Gly  Gly Asp Gly Asn Asp  Met Leu Tyr Gly Asp  Ala Gly Asn 
    1205                 1210                 1215             


Asp Thr  Leu Tyr Gly Gly Leu  Gly Asp Asp Thr Leu  Glu Gly Gly 
    1220                 1225                 1230             


Ala Gly  Asn Asp Trp Phe Gly  Gln Thr Gln Ala Arg  Glu His Asp 
    1235                 1240                 1245             


Val Leu  Arg Gly Gly Asp Gly  Val Asp Thr Val Asp  Tyr Ser Gln 
    1250                 1255                 1260             


Thr Gly  Ala His Ala Gly Ile  Ala Ala Gly Arg Ile  Gly Leu Gly 
    1265                 1270                 1275             


Ile Leu  Ala Asp Leu Gly Ala  Gly Arg Val Asp Lys  Leu Gly Glu 
    1280                 1285                 1290             


Ala Gly  Ser Ser Ala Tyr Asp  Thr Val Ser Gly Ile  Glu Asn Val 
    1295                 1300                 1305             


Val Gly  Thr Glu Leu Ala Asp  Arg Ile Thr Gly Asp  Ala Gln Ala 
    1310                 1315                 1320             


Asn Val  Leu Arg Gly Ala Gly  Gly Ala Asp Val Leu  Ala Gly Gly 
    1325                 1330                 1335             


Glu Gly  Asp Asp Val Leu Leu  Gly Gly Asp Gly Asp  Asp Gln Leu 
    1340                 1345                 1350             


Ser Gly  Asp Ala Gly Arg Asp  Arg Leu Tyr Gly Glu  Ala Gly Asp 
    1355                 1360                 1365             


Asp Trp  Phe Phe Gln Asp Ala  Ala Asn Ala Gly Asn  Leu Leu Asp 
    1370                 1375                 1380             


Gly Gly  Asp Gly Arg Asp Thr  Val Asp Phe Ser Gly  Pro Gly Arg 
    1385                 1390                 1395             


Gly Leu  Asp Ala Gly Ala Lys  Gly Val Phe Leu Ser  Leu Gly Lys 
    1400                 1405                 1410             


Gly Phe  Ala Ser Leu Met Asp  Glu Pro Glu Thr Ser  Asn Val Leu 
    1415                 1420                 1425             


Arg Asn  Ile Glu Asn Ala Val  Gly Ser Ala Arg Asp  Asp Val Leu 
    1430                 1435                 1440             


Ile Gly  Asp Ala Gly Ala Asn  Val Leu Asn Gly Leu  Ala Gly Asn 
    1445                 1450                 1455             


Asp Val  Leu Ser Gly Gly Ala  Gly Asp Asp Val Leu  Leu Gly Asp 
    1460                 1465                 1470             


Glu Gly  Ser Asp Leu Leu Ser  Gly Asp Ala Gly Asn  Asp Asp Leu 
    1475                 1480                 1485             


Phe Gly  Gly Gln Gly Asp Asp  Thr Tyr Leu Phe Gly  Val Gly Tyr 
    1490                 1495                 1500             


Gly His  Asp Thr Ile Tyr Glu  Ser Gly Gly Gly His  Asp Thr Ile 
    1505                 1510                 1515             


Arg Ile  Asn Ala Gly Ala Asp  Gln Leu Trp Phe Ala  Arg Gln Gly 
    1520                 1525                 1530             


Asn Asp  Leu Glu Ile Arg Ile  Leu Gly Thr Asp Asp  Ala Leu Thr 
    1535                 1540                 1545             


Val His  Asp Trp Tyr Arg Asp  Ala Asp His Arg Val  Glu Ile Ile 
    1550                 1555                 1560             


His Ala  Ala Asn Gln Ala Val  Asp Gln Ala Gly Ile  Glu Lys Leu 
    1565                 1570                 1575             


Val Glu  Ala Met Ala Gln Tyr  Pro Asp Pro Gly Ala  Ala Ala Ala 
    1580                 1585                 1590             


Ala Pro  Pro Ala Ala Arg Val  Pro Asp Thr Leu Met  Gln Ser Leu 
    1595                 1600                 1605             


Ala Val  Asn Trp Arg 
    1610             


<210>  74
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of E7 of HPV31

<400>  74

Met Arg Gly Glu Thr Pro Thr Leu Gln Asp Tyr Val Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Ala Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Pro Asp Ser Ser 
            20                  25                  30          


Asp Glu Glu Asp Val Ile Asp Ser Pro Ala Gly Gln Ala Lys Pro Asp 
        35                  40                  45              


Thr Ser Asn Tyr Asn Ile Val Thr Phe Cys Cys Gln Cys Glu Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr Gln Val Asp Ile Arg Ile Leu Gln 
65                  70                  75                  80  


Glu Leu Leu Met Gly Ser Phe Gly Ile Val Cys Pro Asn Cys Ser Thr 
                85                  90                  95      


Arg Leu 
        


<210>  75
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of E7 of HPV33

<400>  75

Met Arg Gly His Lys Pro Thr Leu Lys Glu Tyr Ile Leu Asp Leu Tyr 
1               5                   10                  15      


Pro Glu Pro Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Ser Asp Ser Ser 
            20                  25                  30          


Asp Glu Asp Glu Gly Leu Asp Arg Pro Asp Gly Gln Ala Gln Pro Ala 
        35                  40                  45              


Thr Ala Asp Tyr Tyr Ile Val Thr Cys Cys His Thr Cys Asn Thr Thr 
    50                  55                  60                  


Val Arg Leu Cys Val Asn Ser Thr Ala Ser Asp Leu Arg Thr Ile Gln 
65                  70                  75                  80  


Gln Leu Leu Met Gly Thr Val Asn Ile Val Cys Pro Ser Cys Ala Gln 
                85                  90                  95      


Leu 
    


<210>  76
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of E7 of HPV45

<400>  76

Met His Gly Pro Arg Glu Thr Leu Gln Glu Ile Val Leu His Leu Glu 
1               5                   10                  15      


Pro Gln Asn Glu Leu Asp Pro Val Asp Leu Leu Cys Tyr Glu Gln Leu 
            20                  25                  30          


Ser Glu Ser Glu Glu Glu Asn Asp Glu Ala Asp Gly Val Ser His Ala 
        35                  40                  45              


Gln Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu Cys 
    50                  55                  60                  


Val Cys Cys Lys Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser 
65                  70                  75                  80  


Ala Glu Asp Leu Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser 
                85                  90                  95      


Phe Val Cys Pro Trp Cys Ala Thr Asn Gln 
            100                 105     


<210>  77
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of E7 of HPV52

<400>  77

Met Arg Gly Asp Lys Ala Thr Ile Lys Asp Tyr Ile Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu His Cys Tyr Glu Gln Leu Gly Asp Ser Ser 
            20                  25                  30          


Asp Glu Glu Asp Thr Asp Gly Val Asp Arg Pro Asp Gly Gln Ala Glu 
        35                  40                  45              


Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr Cys His Ser Cys Asp 
    50                  55                  60                  


Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala Thr Asp Leu Arg Thr 
65                  70                  75                  80  


Leu Gln Gln Met Leu Leu Gly Thr Leu Gln Val Val Cys Pro Gly Cys 
                85                  90                  95      


Ala Arg Leu 
            


<210>  78
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified version of protein sequence of E7 of HPV52

<400>  78

Met Arg Gly Asp Lys Ala Thr Ile Lys Asp Tyr Ile Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu His Cys Tyr Glu Gln Leu Gly Asp Ser Ser 
            20                  25                  30          


Asp Glu Glu Asp Thr Asp Gly Val Asp Arg Pro Asp Gly Gln Ala Glu 
        35                  40                  45              


Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr Cys His Ser Cys Asp 
    50                  55                  60                  


Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala Thr Asp Leu Arg Thr 
65                  70                  75                  80  


Leu Gln Gln Leu Leu Met Gly Thr Leu Gln Val Val Cys Pro Gly Cys 
                85                  90                  95      


Ala Arg Leu 
            


<210>  79
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of E7 of HPV 58

<400>  79

Met Arg Gly Asn Asn Pro Thr Leu Arg Glu Tyr Ile Leu Asp Leu His 
1               5                   10                  15      


Pro Glu Pro Thr Asp Leu Phe Cys Tyr Glu Gln Leu Cys Asp Ser Ser 
            20                  25                  30          


Asp Glu Asp Glu Ile Gly Leu Asp Arg Pro Asp Gly Gln Ala Gln Pro 
        35                  40                  45              


Ala Thr Ala Asn Tyr Tyr Ile Val Thr Cys Cys Tyr Thr Cys Asp Thr 
    50                  55                  60                  


Thr Val Arg Leu Cys Ile Asn Ser Thr Thr Thr Asp Val Arg Thr Leu 
65                  70                  75                  80  


Gln Gln Leu Leu Met Gly Thr Cys Thr Ile Val Cys Pro Ser Cys Ala 
                85                  90                  95      


Gln Gln 
        


<210>  80
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide for antigen E7 of HPV16, HPV18 and HPV45 
       acidic-deleted


<220>
<221>  CDS
<222>  (1)..(828)

<400>  80
ggt cag gcg gaa ccg gat cgc gcg cac tac aac atc gtt act ttt tgt         48
Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys           
1               5                   10                  15                

tgc aaa tgt gat tcc act ctg cgc ctg tgt gtg caa tcc acc cac gta         96
Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val           
            20                  25                  30                    

gac att cgc act ctg gaa gac ctg ctg atg ggt acc ctt ggt att gtt        144
Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val           
        35                  40                  45                        

tgt ccg att tgc tcc cag aag ccg gcg tct ggc gtt aac cac caa cac        192
Cys Pro Ile Cys Ser Gln Lys Pro Ala Ser Gly Val Asn His Gln His           
    50                  55                  60                            

ctg ccg gcg cgt cgc gca gag ccg cag cgt cac acc atg ctg tgc atg        240
Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met           
65                  70                  75                  80            

tgc tgt aaa tgt gag gcc cgt atc gag ctg gtc gtt gag tct agc gcc        288
Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala           
                85                  90                  95                

gac gat ctg cgt gcg ttt cag cag ctg ttc ctg aac acg ctg agc ttc        336
Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe           
            100                 105                 110                   

gtt tgc ccg tgg tgt gct agc cag cag ggc gtg tct cac gct cag ctg        384
Val Cys Pro Trp Cys Ala Ser Gln Gln Gly Val Ser His Ala Gln Leu           
        115                 120                 125                       

ccg gca cgt cgt gct gag cct cag cgt cac aaa atc ctg tgc gtg tgc        432
Pro Ala Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu Cys Val Cys           
    130                 135                 140                           

tgc aaa tgc gat ggc cgc atc gaa ctg acc gtg gaa tct agc gca gaa        480
Cys Lys Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser Ala Glu           
145                 150                 155                 160           

gac ctg cgt acg ctg cag caa ctg ttc ctg agc acg ctg tcc ttc gta        528
Asp Leu Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe Val           
                165                 170                 175               

tgc cct tgg tgc gca act aat cag atg cac ggt gac acc ccg acc ctg        576
Cys Pro Trp Cys Ala Thr Asn Gln Met His Gly Asp Thr Pro Thr Leu           
            180                 185                 190                   

cac gaa tac atg ctg gac ctg cag cca gaa acc acc gat ctg tac tgt        624
His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Cys           
        195                 200                 205                       

tac gaa cag ctg aac atg cat ggc cca aaa gct act ctg cag gat atc        672
Tyr Glu Gln Leu Asn Met His Gly Pro Lys Ala Thr Leu Gln Asp Ile           
    210                 215                 220                           

gtc ctg cat ctg gaa cca cag aac gaa atc ccg gta gat ctg ctg tgc        720
Val Leu His Leu Glu Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys           
225                 230                 235                 240           

cat gag cag ctg atg cat ggt ccg cgt gaa acc ctg cag gaa atc gtt        768
His Glu Gln Leu Met His Gly Pro Arg Glu Thr Leu Gln Glu Ile Val           
                245                 250                 255               

ctg cac ctg gaa ccg caa aac gaa ctg gac ccg gtt gac ctg ctg tgc        816
Leu His Leu Glu Pro Gln Asn Glu Leu Asp Pro Val Asp Leu Leu Cys           
            260                 265                 270                   

tat gaa cag ctg                                                        828
Tyr Glu Gln Leu                                                           
        275                                                               


<210>  81
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  81

Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys 
1               5                   10                  15      


Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val 
            20                  25                  30          


Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val 
        35                  40                  45              


Cys Pro Ile Cys Ser Gln Lys Pro Ala Ser Gly Val Asn His Gln His 
    50                  55                  60                  


Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met 
65                  70                  75                  80  


Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala 
                85                  90                  95      


Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe 
            100                 105                 110         


Val Cys Pro Trp Cys Ala Ser Gln Gln Gly Val Ser His Ala Gln Leu 
        115                 120                 125             


Pro Ala Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu Cys Val Cys 
    130                 135                 140                 


Cys Lys Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser Ala Glu 
145                 150                 155                 160 


Asp Leu Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe Val 
                165                 170                 175     


Cys Pro Trp Cys Ala Thr Asn Gln Met His Gly Asp Thr Pro Thr Leu 
            180                 185                 190         


His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Cys 
        195                 200                 205             


Tyr Glu Gln Leu Asn Met His Gly Pro Lys Ala Thr Leu Gln Asp Ile 
    210                 215                 220                 


Val Leu His Leu Glu Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys 
225                 230                 235                 240 


His Glu Gln Leu Met His Gly Pro Arg Glu Thr Leu Gln Glu Ile Val 
                245                 250                 255     


Leu His Leu Glu Pro Gln Asn Glu Leu Asp Pro Val Asp Leu Leu Cys 
            260                 265                 270         


Tyr Glu Gln Leu 
        275     


<210>  82
<211>  933
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide for antigen E7 of HPV16, HPV18 and HPV45 full


<220>
<221>  CDS
<222>  (1)..(933)

<400>  82
gaa gac gaa atc gac ggc cct gcg ggc cag gct gaa cca gat cgt gct         48
Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala           
1               5                   10                  15                

cac tac aac atc gta act ttt tgc tgt aag tgc gat agc act ctg cgt         96
His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg           
            20                  25                  30                    

ctg tgc gta cag tct act cac gtt gat atc cgc act ctg gaa gat ctg        144
Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu           
        35                  40                  45                        

ctg atg ggt acc ctg ggt atc gtc tgc cca atc tgc tct caa aag cct        192
Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys Pro           
    50                  55                  60                            

gct tct ggt gtt aac cat cag cac ctg ccg gct cgt cgc gct gaa cca        240
Ala Ser Gly Val Asn His Gln His Leu Pro Ala Arg Arg Ala Glu Pro           
65                  70                  75                  80            

cag cgt cat acc atg ctg tgc atg tgt tgc aaa tgc gag gct cgc atc        288
Gln Arg His Thr Met Leu Cys Met Cys Cys Lys Cys Glu Ala Arg Ile           
                85                  90                  95                

gaa ctg gtt gtt gaa tcc agc gct gac gac ctg cgt gcg ttt cag caa        336
Glu Leu Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln Gln           
            100                 105                 110                   

ctg ttc ctg aac acg ctg tct ttt gtt tgt ccg tgg tgt gcc tcc cag        384
Leu Phe Leu Asn Thr Leu Ser Phe Val Cys Pro Trp Cys Ala Ser Gln           
        115                 120                 125                       

cag gag aac gat gaa gcg gat ggc gtg tcc cac gcg cag ctg ccg gca        432
Gln Glu Asn Asp Glu Ala Asp Gly Val Ser His Ala Gln Leu Pro Ala           
    130                 135                 140                           

cgt cgt gca gaa ccg cag cgc cac aag att ctg tgc gtt tgc tgt aaa        480
Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu Cys Val Cys Cys Lys           
145                 150                 155                 160           

tgt gat ggc cgt atc gaa ctg act gtg gaa tcc tcc gcg gaa gat ctg        528
Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser Ala Glu Asp Leu           
                165                 170                 175               

cgt acg ctg cag cag ctg ttc ctg tct acc ctg tct ttc gtg tgc ccg        576
Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe Val Cys Pro           
            180                 185                 190                   

tgg tgc gcc acc aat caa atg cac ggc gac acc ccg acc ctg cac gaa        624
Trp Cys Ala Thr Asn Gln Met His Gly Asp Thr Pro Thr Leu His Glu           
        195                 200                 205                       

tac atg ctg gac ctg cag ccg gaa acc acg gat ctg tat tgt tat gaa        672
Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu           
    210                 215                 220                           

cag ctg aac gat agc agc gag gaa atg cac ggt ccg aaa gca act ctg        720
Gln Leu Asn Asp Ser Ser Glu Glu Met His Gly Pro Lys Ala Thr Leu           
225                 230                 235                 240           

cag gac att gtg ctg cat ctg gag cca cag aac gaa atc ccg gtt gat        768
Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn Glu Ile Pro Val Asp           
                245                 250                 255               

ctg ctg tgc cac gag caa ctg agc gat tcc gaa gag gaa aac gac gaa        816
Leu Leu Cys His Glu Gln Leu Ser Asp Ser Glu Glu Glu Asn Asp Glu           
            260                 265                 270                   

att gat atg cat ggt ccg cgc gag acc ctg caa gaa atc gtc ctg cac        864
Ile Asp Met His Gly Pro Arg Glu Thr Leu Gln Glu Ile Val Leu His           
        275                 280                 285                       

ctg gaa ccg caa aac gaa ctg gac cct gta gac ctg ctg tgc tac gaa        912
Leu Glu Pro Gln Asn Glu Leu Asp Pro Val Asp Leu Leu Cys Tyr Glu           
    290                 295                 300                           

cag ctg tcc gaa tct gaa gaa                                            933
Gln Leu Ser Glu Ser Glu Glu                                               
305                 310                                                   


<210>  83
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  83

Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala 
1               5                   10                  15      


His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg 
            20                  25                  30          


Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu 
        35                  40                  45              


Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys Pro 
    50                  55                  60                  


Ala Ser Gly Val Asn His Gln His Leu Pro Ala Arg Arg Ala Glu Pro 
65                  70                  75                  80  


Gln Arg His Thr Met Leu Cys Met Cys Cys Lys Cys Glu Ala Arg Ile 
                85                  90                  95      


Glu Leu Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln Gln 
            100                 105                 110         


Leu Phe Leu Asn Thr Leu Ser Phe Val Cys Pro Trp Cys Ala Ser Gln 
        115                 120                 125             


Gln Glu Asn Asp Glu Ala Asp Gly Val Ser His Ala Gln Leu Pro Ala 
    130                 135                 140                 


Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu Cys Val Cys Cys Lys 
145                 150                 155                 160 


Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser Ala Glu Asp Leu 
                165                 170                 175     


Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe Val Cys Pro 
            180                 185                 190         


Trp Cys Ala Thr Asn Gln Met His Gly Asp Thr Pro Thr Leu His Glu 
        195                 200                 205             


Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu 
    210                 215                 220                 


Gln Leu Asn Asp Ser Ser Glu Glu Met His Gly Pro Lys Ala Thr Leu 
225                 230                 235                 240 


Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn Glu Ile Pro Val Asp 
                245                 250                 255     


Leu Leu Cys His Glu Gln Leu Ser Asp Ser Glu Glu Glu Asn Asp Glu 
            260                 265                 270         


Ile Asp Met His Gly Pro Arg Glu Thr Leu Gln Glu Ile Val Leu His 
        275                 280                 285             


Leu Glu Pro Gln Asn Glu Leu Asp Pro Val Asp Leu Leu Cys Tyr Glu 
    290                 295                 300                 


Gln Leu Ser Glu Ser Glu Glu 
305                 310     


<210>  84
<211>  1080
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide for antigen E7 of HPV16, 18, 33 and 45 
       acidic-deleted


<220>
<221>  CDS
<222>  (1)..(1080)

<400>  84
ggt cag gcg gaa ccg gat cgc gcg cac tac aac atc gtt act ttt tgt         48
Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys           
1               5                   10                  15                

tgc aaa tgt gat tcc act ctg cgc ctg tgt gtg caa tcc acc cac gta         96
Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val           
            20                  25                  30                    

gac atc cgc act ctg gaa gac ctg ctg atg ggt acc ctg ggt att gtt        144
Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val           
        35                  40                  45                        

tgt ccg att tgc tcc cag aag ccg gcg tct ggc gtt aac cac caa cac        192
Cys Pro Ile Cys Ser Gln Lys Pro Ala Ser Gly Val Asn His Gln His           
    50                  55                  60                            

ctg ccg gcg cgt cgc gca gag ccg cag cgt cac acc atg ctg tgc atg        240
Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met           
65                  70                  75                  80            

tgc tgt aaa tgt gag gcc cgt att gaa ctg gtc gtt gag tct agc gcc        288
Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala           
                85                  90                  95                

gac gat ctg cgt gcg ttt cag cag ctg ttc ctg aac acg ctg agc ttc        336
Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe           
            100                 105                 110                   

gtt tgc ccg tgg tgt gct agc cag cag ggc gtg tct cac gct cag ctg        384
Val Cys Pro Trp Cys Ala Ser Gln Gln Gly Val Ser His Ala Gln Leu           
        115                 120                 125                       

ccg gca cgt cgt gct gag cct cag cgt cac aaa atc ctg tgc gtg tgc        432
Pro Ala Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu Cys Val Cys           
    130                 135                 140                           

tgc aaa tgc gat ggc cgc atc gaa ctg acc gtg gaa tct agc gca gaa        480
Cys Lys Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser Ala Glu           
145                 150                 155                 160           

gac ctg cgt acg ctg cag caa ctg ttc ctg agc acg ctg tcc ttc gta        528
Asp Leu Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe Val           
                165                 170                 175               

tgc cct tgg tgc gca act aat cag ggt cag gcg caa ccg gcc acg gcg        576
Cys Pro Trp Cys Ala Thr Asn Gln Gly Gln Ala Gln Pro Ala Thr Ala           
            180                 185                 190                   

gac tac tat atc gtg acc tgt tgc cac acc tgc aac act acc gtt cgc        624
Asp Tyr Tyr Ile Val Thr Cys Cys His Thr Cys Asn Thr Thr Val Arg           
        195                 200                 205                       

ttg tgt gtc aat agc acc gct tcc gat ctg cgt acc att caa caa ctg        672
Leu Cys Val Asn Ser Thr Ala Ser Asp Leu Arg Thr Ile Gln Gln Leu           
    210                 215                 220                           

ctg atg ggt acc gtt aac atc gtg tgc ccg agc tgc gca cag ctg atg        720
Leu Met Gly Thr Val Asn Ile Val Cys Pro Ser Cys Ala Gln Leu Met           
225                 230                 235                 240           

cac ggt gac acc ccg acc ctg cac gaa tac atg ctg gac ctg cag cca        768
His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro           
                245                 250                 255               

gaa acc acc gat ctg tac tgt tac gaa cag ctg aac atg cat ggc cca        816
Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Met His Gly Pro           
            260                 265                 270                   

aaa gct act ctg cag gat atc gtc ctg cat ctg gaa cca cag aac gaa        864
Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn Glu           
        275                 280                 285                       

atc ccg gta gat ctg ctg tgc cat gag cag ctg atg cat ggt ccg cgt        912
Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Met His Gly Pro Arg           
    290                 295                 300                           

gaa acc ctg cag gaa atc gtt ctg cac ctg gaa ccg caa aac gaa ctg        960
Glu Thr Leu Gln Glu Ile Val Leu His Leu Glu Pro Gln Asn Glu Leu           
305                 310                 315                 320           

gac ccg gtt gac ctg ctg tgc tat gaa cag ctg atg cgt ggc cat aag       1008
Asp Pro Val Asp Leu Leu Cys Tyr Glu Gln Leu Met Arg Gly His Lys           
                325                 330                 335               

ccg acg ctg aaa gag tat att ctg gac ctg tac cca gag ccg acg gat       1056
Pro Thr Leu Lys Glu Tyr Ile Leu Asp Leu Tyr Pro Glu Pro Thr Asp           
            340                 345                 350                   

ttg tac tgt tat gaa cag ctg agc                                       1080
Leu Tyr Cys Tyr Glu Gln Leu Ser                                           
        355                 360                                           


<210>  85
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  85

Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys 
1               5                   10                  15      


Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val 
            20                  25                  30          


Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val 
        35                  40                  45              


Cys Pro Ile Cys Ser Gln Lys Pro Ala Ser Gly Val Asn His Gln His 
    50                  55                  60                  


Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met 
65                  70                  75                  80  


Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala 
                85                  90                  95      


Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe 
            100                 105                 110         


Val Cys Pro Trp Cys Ala Ser Gln Gln Gly Val Ser His Ala Gln Leu 
        115                 120                 125             


Pro Ala Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu Cys Val Cys 
    130                 135                 140                 


Cys Lys Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser Ala Glu 
145                 150                 155                 160 


Asp Leu Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe Val 
                165                 170                 175     


Cys Pro Trp Cys Ala Thr Asn Gln Gly Gln Ala Gln Pro Ala Thr Ala 
            180                 185                 190         


Asp Tyr Tyr Ile Val Thr Cys Cys His Thr Cys Asn Thr Thr Val Arg 
        195                 200                 205             


Leu Cys Val Asn Ser Thr Ala Ser Asp Leu Arg Thr Ile Gln Gln Leu 
    210                 215                 220                 


Leu Met Gly Thr Val Asn Ile Val Cys Pro Ser Cys Ala Gln Leu Met 
225                 230                 235                 240 


His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro 
                245                 250                 255     


Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Met His Gly Pro 
            260                 265                 270         


Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn Glu 
        275                 280                 285             


Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Met His Gly Pro Arg 
    290                 295                 300                 


Glu Thr Leu Gln Glu Ile Val Leu His Leu Glu Pro Gln Asn Glu Leu 
305                 310                 315                 320 


Asp Pro Val Asp Leu Leu Cys Tyr Glu Gln Leu Met Arg Gly His Lys 
                325                 330                 335     


Pro Thr Leu Lys Glu Tyr Ile Leu Asp Leu Tyr Pro Glu Pro Thr Asp 
            340                 345                 350         


Leu Tyr Cys Tyr Glu Gln Leu Ser 
        355                 360 


<210>  86
<211>  1224
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide for antigen E7 of HPV16, 18, 33 and 45 full


<220>
<221>  CDS
<222>  (1)..(1224)

<400>  86
gaa gac gaa atc gac ggc cct gcg ggc cag gct gaa cca gat cgt gct         48
Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala           
1               5                   10                  15                

cac tac aac atc gta act ttt tgc tgt aag tgc gat agc act ctg cgt         96
His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg           
            20                  25                  30                    

ctg tgc gta cag tct act cac gtt gat atc cgc act ctg gaa gat ctg        144
Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu           
        35                  40                  45                        

ctg atg ggt acc ctg ggt atc gtc tgc cca atc tgc tct caa aag cct        192
Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys Pro           
    50                  55                  60                            

gct tct ggt gtt aac cat cag cac ctg ccg gct cgt cgc gct gaa cca        240
Ala Ser Gly Val Asn His Gln His Leu Pro Ala Arg Arg Ala Glu Pro           
65                  70                  75                  80            

cag cgt cat acc atg ctg tgc atg tgt tgc aaa tgc gag gct cgc atc        288
Gln Arg His Thr Met Leu Cys Met Cys Cys Lys Cys Glu Ala Arg Ile           
                85                  90                  95                

gaa ctg gtt gtt gaa tcc agc gct gac gac ctg cgt gcg ttt cag caa        336
Glu Leu Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln Gln           
            100                 105                 110                   

ctg ttc ctg aac acg ctg tct ttt gtt tgt ccg tgg tgt gcc tcc cag        384
Leu Phe Leu Asn Thr Leu Ser Phe Val Cys Pro Trp Cys Ala Ser Gln           
        115                 120                 125                       

cag gag aac gat gaa gcg gat ggc gtg tcc cac gcg cag ctg ccg gca        432
Gln Glu Asn Asp Glu Ala Asp Gly Val Ser His Ala Gln Leu Pro Ala           
    130                 135                 140                           

cgt cgt gca gaa ccg cag cgc cac aag att ctg tgc gtt tgc tgt aaa        480
Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu Cys Val Cys Cys Lys           
145                 150                 155                 160           

tgt gat ggc cgt atc gaa ctg act gtg gaa tcc tcc gcg gaa gat ctg        528
Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser Ala Glu Asp Leu           
                165                 170                 175               

cgt acg ctg cag cag ctg ttc ctg tct acc ctg tct ttc gtg tgc ccg        576
Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe Val Cys Pro           
            180                 185                 190                   

tgg tgc gcc acc aat caa tcg gat gaa gat gaa ggt ctg gat cgt ccg        624
Trp Cys Ala Thr Asn Gln Ser Asp Glu Asp Glu Gly Leu Asp Arg Pro           
        195                 200                 205                       

gat ggt caa gcg cag ccg gcg act gca gat tac tat atc gtc act tgt        672
Asp Gly Gln Ala Gln Pro Ala Thr Ala Asp Tyr Tyr Ile Val Thr Cys           
    210                 215                 220                           

tgc cac acc tgc aat acc acc gtg cgt ctg tgt gtg aac agc acg gcg        720
Cys His Thr Cys Asn Thr Thr Val Arg Leu Cys Val Asn Ser Thr Ala           
225                 230                 235                 240           

agc gac ctg cgc acg atc caa cag ttg ttg atg ggc acc gtg aat atc        768
Ser Asp Leu Arg Thr Ile Gln Gln Leu Leu Met Gly Thr Val Asn Ile           
                245                 250                 255               

gtc tgc cca agc tgt gct cag ttg atg cac ggc gac acc ccg acc ctg        816
Val Cys Pro Ser Cys Ala Gln Leu Met His Gly Asp Thr Pro Thr Leu           
            260                 265                 270                   

cac gaa tac atg ctg gac ctg cag ccg gaa acc acg gat ctg tat tgt        864
His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Cys           
        275                 280                 285                       

tat gaa cag ctg aac gat agc agc gag gaa atg cac ggt ccg aaa gca        912
Tyr Glu Gln Leu Asn Asp Ser Ser Glu Glu Met His Gly Pro Lys Ala           
    290                 295                 300                           

act ctg cag gac att gtg ctg cat ctg gag cca cag aac gaa atc ccg        960
Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn Glu Ile Pro           
305                 310                 315                 320           

gtt gat ctg ctg tgc cac gag caa ctg agc gat tcc gaa gag gaa aac       1008
Val Asp Leu Leu Cys His Glu Gln Leu Ser Asp Ser Glu Glu Glu Asn           
                325                 330                 335               

gac gaa att gat atg cat ggt ccg cgc gag acc ctg caa gaa atc gtc       1056
Asp Glu Ile Asp Met His Gly Pro Arg Glu Thr Leu Gln Glu Ile Val           
            340                 345                 350                   

ctg cac ctg gaa ccg caa aac gaa ctg gac cct gta gac ctg ctg tgc       1104
Leu His Leu Glu Pro Gln Asn Glu Leu Asp Pro Val Asp Leu Leu Cys           
        355                 360                 365                       

tac gaa cag ctg tcc gaa tct gaa gaa atg cgt ggt cac aaa ccg acg       1152
Tyr Glu Gln Leu Ser Glu Ser Glu Glu Met Arg Gly His Lys Pro Thr           
    370                 375                 380                           

ctg aaa gag tac atc ctg gac ctg tac ccg gaa cct acg gat ctg tac       1200
Leu Lys Glu Tyr Ile Leu Asp Leu Tyr Pro Glu Pro Thr Asp Leu Tyr           
385                 390                 395                 400           

tgt tat gaa caa ctg agc gat agc                                       1224
Cys Tyr Glu Gln Leu Ser Asp Ser                                           
                405                                                       


<210>  87
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  87

Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala 
1               5                   10                  15      


His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg 
            20                  25                  30          


Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu 
        35                  40                  45              


Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys Pro 
    50                  55                  60                  


Ala Ser Gly Val Asn His Gln His Leu Pro Ala Arg Arg Ala Glu Pro 
65                  70                  75                  80  


Gln Arg His Thr Met Leu Cys Met Cys Cys Lys Cys Glu Ala Arg Ile 
                85                  90                  95      


Glu Leu Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln Gln 
            100                 105                 110         


Leu Phe Leu Asn Thr Leu Ser Phe Val Cys Pro Trp Cys Ala Ser Gln 
        115                 120                 125             


Gln Glu Asn Asp Glu Ala Asp Gly Val Ser His Ala Gln Leu Pro Ala 
    130                 135                 140                 


Arg Arg Ala Glu Pro Gln Arg His Lys Ile Leu Cys Val Cys Cys Lys 
145                 150                 155                 160 


Cys Asp Gly Arg Ile Glu Leu Thr Val Glu Ser Ser Ala Glu Asp Leu 
                165                 170                 175     


Arg Thr Leu Gln Gln Leu Phe Leu Ser Thr Leu Ser Phe Val Cys Pro 
            180                 185                 190         


Trp Cys Ala Thr Asn Gln Ser Asp Glu Asp Glu Gly Leu Asp Arg Pro 
        195                 200                 205             


Asp Gly Gln Ala Gln Pro Ala Thr Ala Asp Tyr Tyr Ile Val Thr Cys 
    210                 215                 220                 


Cys His Thr Cys Asn Thr Thr Val Arg Leu Cys Val Asn Ser Thr Ala 
225                 230                 235                 240 


Ser Asp Leu Arg Thr Ile Gln Gln Leu Leu Met Gly Thr Val Asn Ile 
                245                 250                 255     


Val Cys Pro Ser Cys Ala Gln Leu Met His Gly Asp Thr Pro Thr Leu 
            260                 265                 270         


His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Cys 
        275                 280                 285             


Tyr Glu Gln Leu Asn Asp Ser Ser Glu Glu Met His Gly Pro Lys Ala 
    290                 295                 300                 


Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn Glu Ile Pro 
305                 310                 315                 320 


Val Asp Leu Leu Cys His Glu Gln Leu Ser Asp Ser Glu Glu Glu Asn 
                325                 330                 335     


Asp Glu Ile Asp Met His Gly Pro Arg Glu Thr Leu Gln Glu Ile Val 
            340                 345                 350         


Leu His Leu Glu Pro Gln Asn Glu Leu Asp Pro Val Asp Leu Leu Cys 
        355                 360                 365             


Tyr Glu Gln Leu Ser Glu Ser Glu Glu Met Arg Gly His Lys Pro Thr 
    370                 375                 380                 


Leu Lys Glu Tyr Ile Leu Asp Leu Tyr Pro Glu Pro Thr Asp Leu Tyr 
385                 390                 395                 400 


Cys Tyr Glu Gln Leu Ser Asp Ser 
                405             


<210>  88
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide for antigen E7 of HPV31, 52 and 58 acidic-deleted


<220>
<221>  CDS
<222>  (1)..(759)

<400>  88
gcg ggt caa gcc aaa ccg gat acc tcc aac tac aac att gtg acc ttc         48
Ala Gly Gln Ala Lys Pro Asp Thr Ser Asn Tyr Asn Ile Val Thr Phe           
1               5                   10                  15                

tgt tgt caa tgc gag agc acg ctg cgt ctg tgt gtt caa agc acc cag         96
Cys Cys Gln Cys Glu Ser Thr Leu Arg Leu Cys Val Gln Ser Thr Gln           
            20                  25                  30                    

gtt gac att cgt atc ctg caa gaa ctg ctg atg ggc tct ttt ggc atc        144
Val Asp Ile Arg Ile Leu Gln Glu Leu Leu Met Gly Ser Phe Gly Ile           
        35                  40                  45                        

gtc tgc cca aat tgc agc act cgc ctg ggc cag gcg gag cag gcg acg        192
Val Cys Pro Asn Cys Ser Thr Arg Leu Gly Gln Ala Glu Gln Ala Thr           
    50                  55                  60                            

agc aac tac tac att gtc acg tat tgc cat tcc tgt gat agc act ctg        240
Ser Asn Tyr Tyr Ile Val Thr Tyr Cys His Ser Cys Asp Ser Thr Leu           
65                  70                  75                  80            

cgt ctg tgt atc cac agc acg gca acc gat ctg cgt acc ttg caa caa        288
Arg Leu Cys Ile His Ser Thr Ala Thr Asp Leu Arg Thr Leu Gln Gln           
                85                  90                  95                

ctg ctg atg ggc acc ctg cag gtg gtt tgt ccg ggt tgc gct cgc ctg        336
Leu Leu Met Gly Thr Leu Gln Val Val Cys Pro Gly Cys Ala Arg Leu           
            100                 105                 110                   

ggc cag gcg cag cca gcg acg gcc aat tac tac atc gtt acc tgt tgc        384
Gly Gln Ala Gln Pro Ala Thr Ala Asn Tyr Tyr Ile Val Thr Cys Cys           
        115                 120                 125                       

tat acg tgc gat act acc gtc cgt ctg tgc att aac agc acc acc acg        432
Tyr Thr Cys Asp Thr Thr Val Arg Leu Cys Ile Asn Ser Thr Thr Thr           
    130                 135                 140                           

gac gtg cgt acc ctg caa cag ctg ctg atg ggt acc tgc acg att gtt        480
Asp Val Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Cys Thr Ile Val           
145                 150                 155                 160           

tgt ccg agc tgt gca caa caa atg cgt ggt gaa acg ccg acc ctg cag        528
Cys Pro Ser Cys Ala Gln Gln Met Arg Gly Glu Thr Pro Thr Leu Gln           
                165                 170                 175               

gat tat gtg ttg gac ttg cag ccg gag gca acg gac ctg tac tgc tat        576
Asp Tyr Val Leu Asp Leu Gln Pro Glu Ala Thr Asp Leu Tyr Cys Tyr           
            180                 185                 190                   

gag cag ctg atg cgt ggt gac aag gcc acc att aaa gat tac atc ctg        624
Glu Gln Leu Met Arg Gly Asp Lys Ala Thr Ile Lys Asp Tyr Ile Leu           
        195                 200                 205                       

gac ttg caa ccg gaa acc acc gac ctg cac tgc tat gag cag ctg ggt        672
Asp Leu Gln Pro Glu Thr Thr Asp Leu His Cys Tyr Glu Gln Leu Gly           
    210                 215                 220                           

atg cgc ggt aat aac ccg acc ttg cgt gag tat atc ttg gac ctg cac        720
Met Arg Gly Asn Asn Pro Thr Leu Arg Glu Tyr Ile Leu Asp Leu His           
225                 230                 235                 240           

ccg gag ccg acc gat ctg ttc tgt tac gaa cag ctg tgc                    759
Pro Glu Pro Thr Asp Leu Phe Cys Tyr Glu Gln Leu Cys                       
                245                 250                                   


<210>  89
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  89

Ala Gly Gln Ala Lys Pro Asp Thr Ser Asn Tyr Asn Ile Val Thr Phe 
1               5                   10                  15      


Cys Cys Gln Cys Glu Ser Thr Leu Arg Leu Cys Val Gln Ser Thr Gln 
            20                  25                  30          


Val Asp Ile Arg Ile Leu Gln Glu Leu Leu Met Gly Ser Phe Gly Ile 
        35                  40                  45              


Val Cys Pro Asn Cys Ser Thr Arg Leu Gly Gln Ala Glu Gln Ala Thr 
    50                  55                  60                  


Ser Asn Tyr Tyr Ile Val Thr Tyr Cys His Ser Cys Asp Ser Thr Leu 
65                  70                  75                  80  


Arg Leu Cys Ile His Ser Thr Ala Thr Asp Leu Arg Thr Leu Gln Gln 
                85                  90                  95      


Leu Leu Met Gly Thr Leu Gln Val Val Cys Pro Gly Cys Ala Arg Leu 
            100                 105                 110         


Gly Gln Ala Gln Pro Ala Thr Ala Asn Tyr Tyr Ile Val Thr Cys Cys 
        115                 120                 125             


Tyr Thr Cys Asp Thr Thr Val Arg Leu Cys Ile Asn Ser Thr Thr Thr 
    130                 135                 140                 


Asp Val Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Cys Thr Ile Val 
145                 150                 155                 160 


Cys Pro Ser Cys Ala Gln Gln Met Arg Gly Glu Thr Pro Thr Leu Gln 
                165                 170                 175     


Asp Tyr Val Leu Asp Leu Gln Pro Glu Ala Thr Asp Leu Tyr Cys Tyr 
            180                 185                 190         


Glu Gln Leu Met Arg Gly Asp Lys Ala Thr Ile Lys Asp Tyr Ile Leu 
        195                 200                 205             


Asp Leu Gln Pro Glu Thr Thr Asp Leu His Cys Tyr Glu Gln Leu Gly 
    210                 215                 220                 


Met Arg Gly Asn Asn Pro Thr Leu Arg Glu Tyr Ile Leu Asp Leu His 
225                 230                 235                 240 


Pro Glu Pro Thr Asp Leu Phe Cys Tyr Glu Gln Leu Cys 
                245                 250             


<210>  90
<211>  885
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide for antigen E7 of HPV31, 52 and 58 full


<220>
<221>  CDS
<222>  (1)..(885)

<400>  90
gat gaa gag gat gtc atc gat tcc cca gca ggc caa gca aag ccg gac         48
Asp Glu Glu Asp Val Ile Asp Ser Pro Ala Gly Gln Ala Lys Pro Asp           
1               5                   10                  15                

acc agc aat tac aat atc gtg acc ttc tgc tgc caa tgt gag tcc act         96
Thr Ser Asn Tyr Asn Ile Val Thr Phe Cys Cys Gln Cys Glu Ser Thr           
            20                  25                  30                    

ctg cgt ctg tgc gtt cag agc acc cag gtt gac att cgt att ctg caa        144
Leu Arg Leu Cys Val Gln Ser Thr Gln Val Asp Ile Arg Ile Leu Gln           
        35                  40                  45                        

gaa ttg ttg atg ggt agc ttt ggc att gtg tgt ccg aac tgc agc acc        192
Glu Leu Leu Met Gly Ser Phe Gly Ile Val Cys Pro Asn Cys Ser Thr           
    50                  55                  60                            

cgt ctg agc gat gaa gag gac acc gac ggt gtc gac cgt ccg gac ggc        240
Arg Leu Ser Asp Glu Glu Asp Thr Asp Gly Val Asp Arg Pro Asp Gly           
65                  70                  75                  80            

caa gct gag cag gcg acc agc aac tac tat atc gtt acg tac tgt cac        288
Gln Ala Glu Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr Cys His           
                85                  90                  95                

agc tgc gat agc act ctg cgc ctg tgt att cat agc acg gcc acc gat        336
Ser Cys Asp Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala Thr Asp           
            100                 105                 110                   

ctg cgt acc ctg caa caa ctg ctg atg ggt act ctg cag gtt gtg tgc        384
Leu Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Leu Gln Val Val Cys           
        115                 120                 125                       

cca ggt tgt gct cgt ctg tcc gac gag gac gaa atc ggc ctg gac cgt        432
Pro Gly Cys Ala Arg Leu Ser Asp Glu Asp Glu Ile Gly Leu Asp Arg           
    130                 135                 140                           

cct gat ggc cag gcc cag ccg gca acg gcg aac tat tac att gtg acc        480
Pro Asp Gly Gln Ala Gln Pro Ala Thr Ala Asn Tyr Tyr Ile Val Thr           
145                 150                 155                 160           

tgc tgc tat acg tgc gat acc acg gtc cgt ctg tgc att aac tct acc        528
Cys Cys Tyr Thr Cys Asp Thr Thr Val Arg Leu Cys Ile Asn Ser Thr           
                165                 170                 175               

acc acg gat gtt cgc acg ctg cag caa ctg ctg atg ggt acc tgt acc        576
Thr Thr Asp Val Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Cys Thr           
            180                 185                 190                   

att gtt tgc ccg tct tgt gcc cag cag atg cgc ggt gaa acg ccg acc        624
Ile Val Cys Pro Ser Cys Ala Gln Gln Met Arg Gly Glu Thr Pro Thr           
        195                 200                 205                       

ctg cag gat tat gtt ctg gac ctg caa ccg gag gcg acc gat ctg tat        672
Leu Gln Asp Tyr Val Leu Asp Leu Gln Pro Glu Ala Thr Asp Leu Tyr           
    210                 215                 220                           

tgc tac gag caa ctg ccg gac agc tcg atg cgt ggt gac aag gcg acg        720
Cys Tyr Glu Gln Leu Pro Asp Ser Ser Met Arg Gly Asp Lys Ala Thr           
225                 230                 235                 240           

att aag gac tac atc ttg gat ctg cag ccg gaa acc acc gac ctg cac        768
Ile Lys Asp Tyr Ile Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu His           
                245                 250                 255               

tgc tat gag cag ctg ggt gat tct atg cgc ggt aac aat ccg acc ctg        816
Cys Tyr Glu Gln Leu Gly Asp Ser Met Arg Gly Asn Asn Pro Thr Leu           
            260                 265                 270                   

cgc gag tac att ctg gac ttg cat ccg gaa ccg acg gac ctg ttc tgt        864
Arg Glu Tyr Ile Leu Asp Leu His Pro Glu Pro Thr Asp Leu Phe Cys           
        275                 280                 285                       

tac gag cag ctg tgt gac agc                                            885
Tyr Glu Gln Leu Cys Asp Ser                                               
    290                 295                                               


<210>  91
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  91

Asp Glu Glu Asp Val Ile Asp Ser Pro Ala Gly Gln Ala Lys Pro Asp 
1               5                   10                  15      


Thr Ser Asn Tyr Asn Ile Val Thr Phe Cys Cys Gln Cys Glu Ser Thr 
            20                  25                  30          


Leu Arg Leu Cys Val Gln Ser Thr Gln Val Asp Ile Arg Ile Leu Gln 
        35                  40                  45              


Glu Leu Leu Met Gly Ser Phe Gly Ile Val Cys Pro Asn Cys Ser Thr 
    50                  55                  60                  


Arg Leu Ser Asp Glu Glu Asp Thr Asp Gly Val Asp Arg Pro Asp Gly 
65                  70                  75                  80  


Gln Ala Glu Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr Cys His 
                85                  90                  95      


Ser Cys Asp Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala Thr Asp 
            100                 105                 110         


Leu Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Leu Gln Val Val Cys 
        115                 120                 125             


Pro Gly Cys Ala Arg Leu Ser Asp Glu Asp Glu Ile Gly Leu Asp Arg 
    130                 135                 140                 


Pro Asp Gly Gln Ala Gln Pro Ala Thr Ala Asn Tyr Tyr Ile Val Thr 
145                 150                 155                 160 


Cys Cys Tyr Thr Cys Asp Thr Thr Val Arg Leu Cys Ile Asn Ser Thr 
                165                 170                 175     


Thr Thr Asp Val Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Cys Thr 
            180                 185                 190         


Ile Val Cys Pro Ser Cys Ala Gln Gln Met Arg Gly Glu Thr Pro Thr 
        195                 200                 205             


Leu Gln Asp Tyr Val Leu Asp Leu Gln Pro Glu Ala Thr Asp Leu Tyr 
    210                 215                 220                 


Cys Tyr Glu Gln Leu Pro Asp Ser Ser Met Arg Gly Asp Lys Ala Thr 
225                 230                 235                 240 


Ile Lys Asp Tyr Ile Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu His 
                245                 250                 255     


Cys Tyr Glu Gln Leu Gly Asp Ser Met Arg Gly Asn Asn Pro Thr Leu 
            260                 265                 270         


Arg Glu Tyr Ile Leu Asp Leu His Pro Glu Pro Thr Asp Leu Phe Cys 
        275                 280                 285             


Tyr Glu Gln Leu Cys Asp Ser 
    290                 295 


<210>  92
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide for antigen E7 of HPV31, 33 and 52 acidic-deleted


<220>
<221>  CDS
<222>  (1)..(759)

<400>  92
gcg ggt caa gcc aaa ccg gat acc tcc aac tac aac att gtg acc ttc         48
Ala Gly Gln Ala Lys Pro Asp Thr Ser Asn Tyr Asn Ile Val Thr Phe           
1               5                   10                  15                

tgt tgt caa tgc gag agc acg ctg cgt ctg tgt gtt caa agc acc cag         96
Cys Cys Gln Cys Glu Ser Thr Leu Arg Leu Cys Val Gln Ser Thr Gln           
            20                  25                  30                    

gtt gac att cgt atc ctg caa gaa ctg ctg atg ggc tct ttt ggc atc        144
Val Asp Ile Arg Ile Leu Gln Glu Leu Leu Met Gly Ser Phe Gly Ile           
        35                  40                  45                        

gtc tgc cca aat tgc agc act cgc ctg ggt cag gcg caa ccg gcc acg        192
Val Cys Pro Asn Cys Ser Thr Arg Leu Gly Gln Ala Gln Pro Ala Thr           
    50                  55                  60                            

gcg gac tac tat atc gtg acc tgt tgc cac acc tgc aac act acc gtt        240
Ala Asp Tyr Tyr Ile Val Thr Cys Cys His Thr Cys Asn Thr Thr Val           
65                  70                  75                  80            

cgc ttg tgt gtc aat agc acc gct tcc gat ctg cgt acc att caa caa        288
Arg Leu Cys Val Asn Ser Thr Ala Ser Asp Leu Arg Thr Ile Gln Gln           
                85                  90                  95                

ctg ctg atg ggt acc gtt aac atc gtg tgc ccg agc tgc gca cag ctg        336
Leu Leu Met Gly Thr Val Asn Ile Val Cys Pro Ser Cys Ala Gln Leu           
            100                 105                 110                   

ggc cag gcg gag cag gcg acg agc aac tac tac att gtc acg tat tgc        384
Gly Gln Ala Glu Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr Cys           
        115                 120                 125                       

cat tcc tgt gat agc act ctg cgt ctg tgt atc cac agc acg gca acc        432
His Ser Cys Asp Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala Thr           
    130                 135                 140                           

gat ctg cgt acc ttg caa caa ctg ctg atg ggc acc ctg cag gtg gtt        480
Asp Leu Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Leu Gln Val Val           
145                 150                 155                 160           

tgt ccg ggt tgc gct cgc ctg atg cgt ggt gaa acg ccg acc ctg cag        528
Cys Pro Gly Cys Ala Arg Leu Met Arg Gly Glu Thr Pro Thr Leu Gln           
                165                 170                 175               

gat tat gtg ttg gac ttg cag ccg gag gca acg gac ctg tac tgc tat        576
Asp Tyr Val Leu Asp Leu Gln Pro Glu Ala Thr Asp Leu Tyr Cys Tyr           
            180                 185                 190                   

gag cag ctg atg cgt ggc cat aag ccg acg ctg aaa gag tat att ctg        624
Glu Gln Leu Met Arg Gly His Lys Pro Thr Leu Lys Glu Tyr Ile Leu           
        195                 200                 205                       

gac ctg tac cca gag ccg acg gat ttg tac tgt tat gaa cag ctg agc        672
Asp Leu Tyr Pro Glu Pro Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Ser           
    210                 215                 220                           

atg cgt ggt gac aag gcc acc att aaa gat tac atc ctg gac ttg caa        720
Met Arg Gly Asp Lys Ala Thr Ile Lys Asp Tyr Ile Leu Asp Leu Gln           
225                 230                 235                 240           

ccg gaa acc acc gac ctg cac tgc tat gag cag ctg ggt                    759
Pro Glu Thr Thr Asp Leu His Cys Tyr Glu Gln Leu Gly                       
                245                 250                                   


<210>  93
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  93

Ala Gly Gln Ala Lys Pro Asp Thr Ser Asn Tyr Asn Ile Val Thr Phe 
1               5                   10                  15      


Cys Cys Gln Cys Glu Ser Thr Leu Arg Leu Cys Val Gln Ser Thr Gln 
            20                  25                  30          


Val Asp Ile Arg Ile Leu Gln Glu Leu Leu Met Gly Ser Phe Gly Ile 
        35                  40                  45              


Val Cys Pro Asn Cys Ser Thr Arg Leu Gly Gln Ala Gln Pro Ala Thr 
    50                  55                  60                  


Ala Asp Tyr Tyr Ile Val Thr Cys Cys His Thr Cys Asn Thr Thr Val 
65                  70                  75                  80  


Arg Leu Cys Val Asn Ser Thr Ala Ser Asp Leu Arg Thr Ile Gln Gln 
                85                  90                  95      


Leu Leu Met Gly Thr Val Asn Ile Val Cys Pro Ser Cys Ala Gln Leu 
            100                 105                 110         


Gly Gln Ala Glu Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr Cys 
        115                 120                 125             


His Ser Cys Asp Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala Thr 
    130                 135                 140                 


Asp Leu Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Leu Gln Val Val 
145                 150                 155                 160 


Cys Pro Gly Cys Ala Arg Leu Met Arg Gly Glu Thr Pro Thr Leu Gln 
                165                 170                 175     


Asp Tyr Val Leu Asp Leu Gln Pro Glu Ala Thr Asp Leu Tyr Cys Tyr 
            180                 185                 190         


Glu Gln Leu Met Arg Gly His Lys Pro Thr Leu Lys Glu Tyr Ile Leu 
        195                 200                 205             


Asp Leu Tyr Pro Glu Pro Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Ser 
    210                 215                 220                 


Met Arg Gly Asp Lys Ala Thr Ile Lys Asp Tyr Ile Leu Asp Leu Gln 
225                 230                 235                 240 


Pro Glu Thr Thr Asp Leu His Cys Tyr Glu Gln Leu Gly 
                245                 250             


<210>  94
<211>  882
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide for antigen E7 of HPV31, 33 and 52 full


<220>
<221>  CDS
<222>  (1)..(882)

<400>  94
gat gaa gag gat gtc atc gat tcc cca gca ggc caa gca aag ccg gac         48
Asp Glu Glu Asp Val Ile Asp Ser Pro Ala Gly Gln Ala Lys Pro Asp           
1               5                   10                  15                

acc agc aat tac aat atc gtg acc ttc tgc tgc caa tgt gag tcc act         96
Thr Ser Asn Tyr Asn Ile Val Thr Phe Cys Cys Gln Cys Glu Ser Thr           
            20                  25                  30                    

ctg cgt ctg tgc gtt cag agc acc cag gtt gac att cgt att ctg caa        144
Leu Arg Leu Cys Val Gln Ser Thr Gln Val Asp Ile Arg Ile Leu Gln           
        35                  40                  45                        

gaa ttg ttg atg ggt agc ttt ggc att gtg tgt ccg aac tgc agc acc        192
Glu Leu Leu Met Gly Ser Phe Gly Ile Val Cys Pro Asn Cys Ser Thr           
    50                  55                  60                            

cgt ctg tcg gat gaa gat gaa ggt ctg gat cgt ccg gat ggt caa gcg        240
Arg Leu Ser Asp Glu Asp Glu Gly Leu Asp Arg Pro Asp Gly Gln Ala           
65                  70                  75                  80            

cag ccg gcg act gca gat tac tat atc gtc act tgt tgc cac acc tgc        288
Gln Pro Ala Thr Ala Asp Tyr Tyr Ile Val Thr Cys Cys His Thr Cys           
                85                  90                  95                

aat acc acc gtg cgt ctg tgt gtg aac agc acg gcg agc gac ctg cgc        336
Asn Thr Thr Val Arg Leu Cys Val Asn Ser Thr Ala Ser Asp Leu Arg           
            100                 105                 110                   

acg atc caa cag ttg ttg atg ggc acc gtg aat atc gtc tgc cca agc        384
Thr Ile Gln Gln Leu Leu Met Gly Thr Val Asn Ile Val Cys Pro Ser           
        115                 120                 125                       

tgt gct cag ttg agc gat gaa gag gac acc gac ggt gtc gac cgt ccg        432
Cys Ala Gln Leu Ser Asp Glu Glu Asp Thr Asp Gly Val Asp Arg Pro           
    130                 135                 140                           

gac ggc caa gct gag cag gcg acc agc aac tac tat atc gtt acg tac        480
Asp Gly Gln Ala Glu Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr           
145                 150                 155                 160           

tgt cac agc tgc gat agc act ctg cgc ctg tgt att cat agc acg gcc        528
Cys His Ser Cys Asp Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala           
                165                 170                 175               

acc gat ctg cgt acc ctg caa caa ctg ctg atg ggt act ctg cag gtt        576
Thr Asp Leu Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Leu Gln Val           
            180                 185                 190                   

gtg tgc cca ggt tgt gct cgt ctg atg cgc ggt gaa acg ccg acc ctg        624
Val Cys Pro Gly Cys Ala Arg Leu Met Arg Gly Glu Thr Pro Thr Leu           
        195                 200                 205                       

cag gat tat gtt ctg gac ctg caa ccg gag gcg acc gat ctg tat tgc        672
Gln Asp Tyr Val Leu Asp Leu Gln Pro Glu Ala Thr Asp Leu Tyr Cys           
    210                 215                 220                           

tac gag caa ctg ccg gac agc tcg atg cgt ggt cac aaa ccg acg ctg        720
Tyr Glu Gln Leu Pro Asp Ser Ser Met Arg Gly His Lys Pro Thr Leu           
225                 230                 235                 240           

aaa gag tac atc ctg gac ctg tac ccg gaa cct acg gat ctg tac tgt        768
Lys Glu Tyr Ile Leu Asp Leu Tyr Pro Glu Pro Thr Asp Leu Tyr Cys           
                245                 250                 255               

tat gaa caa ctg agc gat agc atg cgt ggt gac aag gcg acg att aag        816
Tyr Glu Gln Leu Ser Asp Ser Met Arg Gly Asp Lys Ala Thr Ile Lys           
            260                 265                 270                   

gac tac atc ttg gat ctg cag ccg gaa acc acc gac ctg cac tgc tat        864
Asp Tyr Ile Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu His Cys Tyr           
        275                 280                 285                       

gag cag ctg ggt gat tct                                                882
Glu Gln Leu Gly Asp Ser                                                   
    290                                                                   


<210>  95
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  95

Asp Glu Glu Asp Val Ile Asp Ser Pro Ala Gly Gln Ala Lys Pro Asp 
1               5                   10                  15      


Thr Ser Asn Tyr Asn Ile Val Thr Phe Cys Cys Gln Cys Glu Ser Thr 
            20                  25                  30          


Leu Arg Leu Cys Val Gln Ser Thr Gln Val Asp Ile Arg Ile Leu Gln 
        35                  40                  45              


Glu Leu Leu Met Gly Ser Phe Gly Ile Val Cys Pro Asn Cys Ser Thr 
    50                  55                  60                  


Arg Leu Ser Asp Glu Asp Glu Gly Leu Asp Arg Pro Asp Gly Gln Ala 
65                  70                  75                  80  


Gln Pro Ala Thr Ala Asp Tyr Tyr Ile Val Thr Cys Cys His Thr Cys 
                85                  90                  95      


Asn Thr Thr Val Arg Leu Cys Val Asn Ser Thr Ala Ser Asp Leu Arg 
            100                 105                 110         


Thr Ile Gln Gln Leu Leu Met Gly Thr Val Asn Ile Val Cys Pro Ser 
        115                 120                 125             


Cys Ala Gln Leu Ser Asp Glu Glu Asp Thr Asp Gly Val Asp Arg Pro 
    130                 135                 140                 


Asp Gly Gln Ala Glu Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr 
145                 150                 155                 160 


Cys His Ser Cys Asp Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala 
                165                 170                 175     


Thr Asp Leu Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Leu Gln Val 
            180                 185                 190         


Val Cys Pro Gly Cys Ala Arg Leu Met Arg Gly Glu Thr Pro Thr Leu 
        195                 200                 205             


Gln Asp Tyr Val Leu Asp Leu Gln Pro Glu Ala Thr Asp Leu Tyr Cys 
    210                 215                 220                 


Tyr Glu Gln Leu Pro Asp Ser Ser Met Arg Gly His Lys Pro Thr Leu 
225                 230                 235                 240 


Lys Glu Tyr Ile Leu Asp Leu Tyr Pro Glu Pro Thr Asp Leu Tyr Cys 
                245                 250                 255     


Tyr Glu Gln Leu Ser Asp Ser Met Arg Gly Asp Lys Ala Thr Ile Lys 
            260                 265                 270         


Asp Tyr Ile Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu His Cys Tyr 
        275                 280                 285             


Glu Gln Leu Gly Asp Ser 
    290                 


<210>  96
<211>  1011
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide for antigen E7 of HPV31, 33, 52 and 58 
       acidic-deleted


<220>
<221>  CDS
<222>  (1)..(1011)

<400>  96
gcg ggt caa gcg aag ccg gat acg agc aac tat aac att gtc acg ttc         48
Ala Gly Gln Ala Lys Pro Asp Thr Ser Asn Tyr Asn Ile Val Thr Phe           
1               5                   10                  15                

tgc tgc cag tgt gaa agc acc ttg cgt ctg tgt gtc cag agc acc caa         96
Cys Cys Gln Cys Glu Ser Thr Leu Arg Leu Cys Val Gln Ser Thr Gln           
            20                  25                  30                    

gtt gac atc cgt att ctg cag gag ttg ctg atg ggc agc ttt ggc atc        144
Val Asp Ile Arg Ile Leu Gln Glu Leu Leu Met Gly Ser Phe Gly Ile           
        35                  40                  45                        

gtg tgc ccg aat tgc agc act cgc ctg ggt cag gca cag ccg gcc acc        192
Val Cys Pro Asn Cys Ser Thr Arg Leu Gly Gln Ala Gln Pro Ala Thr           
    50                  55                  60                            

gct gac tac tac att gtt act tgt tgc cat acc tgc aat acc acg gtc        240
Ala Asp Tyr Tyr Ile Val Thr Cys Cys His Thr Cys Asn Thr Thr Val           
65                  70                  75                  80            

cgc ctg tgc gtc aat tcc acc gct tcc gac ttg cgt acc att cag caa        288
Arg Leu Cys Val Asn Ser Thr Ala Ser Asp Leu Arg Thr Ile Gln Gln           
                85                  90                  95                

ctg ctg atg ggc acg gtt aac atc gtt tgc ccg tct tgt gcg cag ctg        336
Leu Leu Met Gly Thr Val Asn Ile Val Cys Pro Ser Cys Ala Gln Leu           
            100                 105                 110                   

ggc caa gcg gaa cag gcg acg agc aat tac tac atc gtg act tac tgt        384
Gly Gln Ala Glu Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr Cys           
        115                 120                 125                       

cac tcg tgt gac agc acg ctg cgt ttg tgc att cac agc acc gcg acc        432
His Ser Cys Asp Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala Thr           
    130                 135                 140                           

gat ctg cgt acg ctg caa caa ttg ctg atg ggt acc ctg cag gtg gtg        480
Asp Leu Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Leu Gln Val Val           
145                 150                 155                 160           

tgc cct ggt tgc gca cgt ctg ggt caa gct caa ccg gca acc gcg aac        528
Cys Pro Gly Cys Ala Arg Leu Gly Gln Ala Gln Pro Ala Thr Ala Asn           
                165                 170                 175               

tac tat atc gtt acg tgt tgt tat acg tgt gat acc acc gtt cgt ctg        576
Tyr Tyr Ile Val Thr Cys Cys Tyr Thr Cys Asp Thr Thr Val Arg Leu           
            180                 185                 190                   

tgc atc aac agc acc acc acc gat gtc cgc acg ctg caa caa ctg ctg        624
Cys Ile Asn Ser Thr Thr Thr Asp Val Arg Thr Leu Gln Gln Leu Leu           
        195                 200                 205                       

atg ggt acg tgt acg att gtt tgc ccg agc tgt gcc cag caa atg cgt        672
Met Gly Thr Cys Thr Ile Val Cys Pro Ser Cys Ala Gln Gln Met Arg           
    210                 215                 220                           

ggt gaa acc cca acg ctg cag gac tac gtg ctg gat ttg cag ccg gaa        720
Gly Glu Thr Pro Thr Leu Gln Asp Tyr Val Leu Asp Leu Gln Pro Glu           
225                 230                 235                 240           

gca acc gac ctg tac tgc tac gag cag ctg atg cgt ggt cac aag ccg        768
Ala Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Met Arg Gly His Lys Pro           
                245                 250                 255               

acg ctg aaa gag tat atc ttg gac ctg tat ccg gag cct acc gat ctg        816
Thr Leu Lys Glu Tyr Ile Leu Asp Leu Tyr Pro Glu Pro Thr Asp Leu           
            260                 265                 270                   

tat tgc tat gaa cag ctg agc atg cgt ggc gat aag gcg acc atc aaa        864
Tyr Cys Tyr Glu Gln Leu Ser Met Arg Gly Asp Lys Ala Thr Ile Lys           
        275                 280                 285                       

gac tac att ctg gac ttg cag ccg gaa acc acg gat ctg cat tgc tac        912
Asp Tyr Ile Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu His Cys Tyr           
    290                 295                 300                           

gaa caa ctg ggc atg cgc ggt aac aat ccg acc ctg cgc gag tat atc        960
Glu Gln Leu Gly Met Arg Gly Asn Asn Pro Thr Leu Arg Glu Tyr Ile           
305                 310                 315                 320           

ctg gat ctg cac cca gag ccg act gac ctg ttc tgc tat gag cag ttg       1008
Leu Asp Leu His Pro Glu Pro Thr Asp Leu Phe Cys Tyr Glu Gln Leu           
                325                 330                 335               

tgc                                                                   1011
Cys                                                                       
                                                                          


<210>  97
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  97

Ala Gly Gln Ala Lys Pro Asp Thr Ser Asn Tyr Asn Ile Val Thr Phe 
1               5                   10                  15      


Cys Cys Gln Cys Glu Ser Thr Leu Arg Leu Cys Val Gln Ser Thr Gln 
            20                  25                  30          


Val Asp Ile Arg Ile Leu Gln Glu Leu Leu Met Gly Ser Phe Gly Ile 
        35                  40                  45              


Val Cys Pro Asn Cys Ser Thr Arg Leu Gly Gln Ala Gln Pro Ala Thr 
    50                  55                  60                  


Ala Asp Tyr Tyr Ile Val Thr Cys Cys His Thr Cys Asn Thr Thr Val 
65                  70                  75                  80  


Arg Leu Cys Val Asn Ser Thr Ala Ser Asp Leu Arg Thr Ile Gln Gln 
                85                  90                  95      


Leu Leu Met Gly Thr Val Asn Ile Val Cys Pro Ser Cys Ala Gln Leu 
            100                 105                 110         


Gly Gln Ala Glu Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr Cys 
        115                 120                 125             


His Ser Cys Asp Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala Thr 
    130                 135                 140                 


Asp Leu Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Leu Gln Val Val 
145                 150                 155                 160 


Cys Pro Gly Cys Ala Arg Leu Gly Gln Ala Gln Pro Ala Thr Ala Asn 
                165                 170                 175     


Tyr Tyr Ile Val Thr Cys Cys Tyr Thr Cys Asp Thr Thr Val Arg Leu 
            180                 185                 190         


Cys Ile Asn Ser Thr Thr Thr Asp Val Arg Thr Leu Gln Gln Leu Leu 
        195                 200                 205             


Met Gly Thr Cys Thr Ile Val Cys Pro Ser Cys Ala Gln Gln Met Arg 
    210                 215                 220                 


Gly Glu Thr Pro Thr Leu Gln Asp Tyr Val Leu Asp Leu Gln Pro Glu 
225                 230                 235                 240 


Ala Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Met Arg Gly His Lys Pro 
                245                 250                 255     


Thr Leu Lys Glu Tyr Ile Leu Asp Leu Tyr Pro Glu Pro Thr Asp Leu 
            260                 265                 270         


Tyr Cys Tyr Glu Gln Leu Ser Met Arg Gly Asp Lys Ala Thr Ile Lys 
        275                 280                 285             


Asp Tyr Ile Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu His Cys Tyr 
    290                 295                 300                 


Glu Gln Leu Gly Met Arg Gly Asn Asn Pro Thr Leu Arg Glu Tyr Ile 
305                 310                 315                 320 


Leu Asp Leu His Pro Glu Pro Thr Asp Leu Phe Cys Tyr Glu Gln Leu 
                325                 330                 335     


Cys 
    


<210>  98
<211>  1176
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full polynucleotide for antigen E7 of HPV31, 33, 52 and 58


<220>
<221>  CDS
<222>  (1)..(1176)

<400>  98
gat gaa gag gat gtc atc gat tcc cca gca ggc caa gca aag ccg gac         48
Asp Glu Glu Asp Val Ile Asp Ser Pro Ala Gly Gln Ala Lys Pro Asp           
1               5                   10                  15                

acc agc aat tac aat atc gtg acc ttc tgc tgc caa tgt gag tcc act         96
Thr Ser Asn Tyr Asn Ile Val Thr Phe Cys Cys Gln Cys Glu Ser Thr           
            20                  25                  30                    

ctg cgt ctg tgc gtt cag agc acc cag gtt gac att cgt att ctg caa        144
Leu Arg Leu Cys Val Gln Ser Thr Gln Val Asp Ile Arg Ile Leu Gln           
        35                  40                  45                        

gaa ttg ttg atg ggt agc ttt ggc att gtg tgt ccg aac tgc agc acc        192
Glu Leu Leu Met Gly Ser Phe Gly Ile Val Cys Pro Asn Cys Ser Thr           
    50                  55                  60                            

cgt ctg tcg gat gaa gat gaa ggt ctg gat cgt ccg gat ggt caa gcg        240
Arg Leu Ser Asp Glu Asp Glu Gly Leu Asp Arg Pro Asp Gly Gln Ala           
65                  70                  75                  80            

cag ccg gcg act gca gat tac tat atc gtc act tgt tgc cac acc tgc        288
Gln Pro Ala Thr Ala Asp Tyr Tyr Ile Val Thr Cys Cys His Thr Cys           
                85                  90                  95                

aat acc acc gtg cgt ctg tgt gtg aac agc acg gcg agc gac ctg cgc        336
Asn Thr Thr Val Arg Leu Cys Val Asn Ser Thr Ala Ser Asp Leu Arg           
            100                 105                 110                   

acg atc caa cag ttg ttg atg ggc acc gtg aat atc gtc tgc cca agc        384
Thr Ile Gln Gln Leu Leu Met Gly Thr Val Asn Ile Val Cys Pro Ser           
        115                 120                 125                       

tgt gct cag ttg agc gat gaa gag gac acc gac ggt gtc gac cgt ccg        432
Cys Ala Gln Leu Ser Asp Glu Glu Asp Thr Asp Gly Val Asp Arg Pro           
    130                 135                 140                           

gac ggc caa gct gag cag gcg acc agc aac tac tat atc gtt acg tac        480
Asp Gly Gln Ala Glu Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr           
145                 150                 155                 160           

tgt cac agc tgc gat agc act ctg cgc ctg tgt att cat agc acg gcc        528
Cys His Ser Cys Asp Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala           
                165                 170                 175               

acc gat ctg cgt acc ctg caa caa ctg ctg atg ggt act ctg cag gtt        576
Thr Asp Leu Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Leu Gln Val           
            180                 185                 190                   

gtg tgc cca ggt tgt gct cgt ctg tcc gac gag gac gaa atc ggc ctg        624
Val Cys Pro Gly Cys Ala Arg Leu Ser Asp Glu Asp Glu Ile Gly Leu           
        195                 200                 205                       

gac cgt cct gat ggc cag gcc cag ccg gca acg gcg aac tat tac att        672
Asp Arg Pro Asp Gly Gln Ala Gln Pro Ala Thr Ala Asn Tyr Tyr Ile           
    210                 215                 220                           

gtg acc tgc tgc tat acg tgc gat acc acg gtc cgt ctg tgc att aac        720
Val Thr Cys Cys Tyr Thr Cys Asp Thr Thr Val Arg Leu Cys Ile Asn           
225                 230                 235                 240           

tct acc acc acg gat gtt cgc acg ctg cag caa ctg ctg atg ggt acc        768
Ser Thr Thr Thr Asp Val Arg Thr Leu Gln Gln Leu Leu Met Gly Thr           
                245                 250                 255               

tgt acc att gtt tgc ccg tct tgt gcc cag cag atg cgc ggt gaa acg        816
Cys Thr Ile Val Cys Pro Ser Cys Ala Gln Gln Met Arg Gly Glu Thr           
            260                 265                 270                   

ccg acc ctg cag gat tat gtt ctg gac ctg caa ccg gag gcg acc gat        864
Pro Thr Leu Gln Asp Tyr Val Leu Asp Leu Gln Pro Glu Ala Thr Asp           
        275                 280                 285                       

ctg tat tgc tac gag caa ctg ccg gac agc tcg atg cgt ggt cac aaa        912
Leu Tyr Cys Tyr Glu Gln Leu Pro Asp Ser Ser Met Arg Gly His Lys           
    290                 295                 300                           

ccg acg ctg aaa gag tac atc ctg gac ctg tac ccg gaa cct acg gat        960
Pro Thr Leu Lys Glu Tyr Ile Leu Asp Leu Tyr Pro Glu Pro Thr Asp           
305                 310                 315                 320           

ctg tac tgt tat gaa caa ctg agc gat agc atg cgt ggt gac aag gcg       1008
Leu Tyr Cys Tyr Glu Gln Leu Ser Asp Ser Met Arg Gly Asp Lys Ala           
                325                 330                 335               

acg att aag gac tac atc ttg gat ctg cag ccg gaa acc acc gac ctg       1056
Thr Ile Lys Asp Tyr Ile Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu           
            340                 345                 350                   

cac tgc tat gag cag ctg ggt gat tct atg cgc ggt aac aat ccg acc       1104
His Cys Tyr Glu Gln Leu Gly Asp Ser Met Arg Gly Asn Asn Pro Thr           
        355                 360                 365                       

ctg cgc gag tac att ctg gac ttg cat ccg gaa ccg acg gac ctg ttc       1152
Leu Arg Glu Tyr Ile Leu Asp Leu His Pro Glu Pro Thr Asp Leu Phe           
    370                 375                 380                           

tgt tac gag cag ctg tgt gac agc                                       1176
Cys Tyr Glu Gln Leu Cys Asp Ser                                           
385                 390                                                   


<210>  99
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  99

Asp Glu Glu Asp Val Ile Asp Ser Pro Ala Gly Gln Ala Lys Pro Asp 
1               5                   10                  15      


Thr Ser Asn Tyr Asn Ile Val Thr Phe Cys Cys Gln Cys Glu Ser Thr 
            20                  25                  30          


Leu Arg Leu Cys Val Gln Ser Thr Gln Val Asp Ile Arg Ile Leu Gln 
        35                  40                  45              


Glu Leu Leu Met Gly Ser Phe Gly Ile Val Cys Pro Asn Cys Ser Thr 
    50                  55                  60                  


Arg Leu Ser Asp Glu Asp Glu Gly Leu Asp Arg Pro Asp Gly Gln Ala 
65                  70                  75                  80  


Gln Pro Ala Thr Ala Asp Tyr Tyr Ile Val Thr Cys Cys His Thr Cys 
                85                  90                  95      


Asn Thr Thr Val Arg Leu Cys Val Asn Ser Thr Ala Ser Asp Leu Arg 
            100                 105                 110         


Thr Ile Gln Gln Leu Leu Met Gly Thr Val Asn Ile Val Cys Pro Ser 
        115                 120                 125             


Cys Ala Gln Leu Ser Asp Glu Glu Asp Thr Asp Gly Val Asp Arg Pro 
    130                 135                 140                 


Asp Gly Gln Ala Glu Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr 
145                 150                 155                 160 


Cys His Ser Cys Asp Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala 
                165                 170                 175     


Thr Asp Leu Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Leu Gln Val 
            180                 185                 190         


Val Cys Pro Gly Cys Ala Arg Leu Ser Asp Glu Asp Glu Ile Gly Leu 
        195                 200                 205             


Asp Arg Pro Asp Gly Gln Ala Gln Pro Ala Thr Ala Asn Tyr Tyr Ile 
    210                 215                 220                 


Val Thr Cys Cys Tyr Thr Cys Asp Thr Thr Val Arg Leu Cys Ile Asn 
225                 230                 235                 240 


Ser Thr Thr Thr Asp Val Arg Thr Leu Gln Gln Leu Leu Met Gly Thr 
                245                 250                 255     


Cys Thr Ile Val Cys Pro Ser Cys Ala Gln Gln Met Arg Gly Glu Thr 
            260                 265                 270         


Pro Thr Leu Gln Asp Tyr Val Leu Asp Leu Gln Pro Glu Ala Thr Asp 
        275                 280                 285             


Leu Tyr Cys Tyr Glu Gln Leu Pro Asp Ser Ser Met Arg Gly His Lys 
    290                 295                 300                 


Pro Thr Leu Lys Glu Tyr Ile Leu Asp Leu Tyr Pro Glu Pro Thr Asp 
305                 310                 315                 320 


Leu Tyr Cys Tyr Glu Gln Leu Ser Asp Ser Met Arg Gly Asp Lys Ala 
                325                 330                 335     


Thr Ile Lys Asp Tyr Ile Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu 
            340                 345                 350         


His Cys Tyr Glu Gln Leu Gly Asp Ser Met Arg Gly Asn Asn Pro Thr 
        355                 360                 365             


Leu Arg Glu Tyr Ile Leu Asp Leu His Pro Glu Pro Thr Asp Leu Phe 
    370                 375                 380                 


Cys Tyr Glu Gln Leu Cys Asp Ser 
385                 390         


