                         SEQUENCE LISTING

<110>  Centre National de la Recherche Scientifique
 
<120>  Use of Rad18 inhibitors in the treatment of tumors

<130>  B1949PC

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  1669
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (37)..(1524)

<400>  1
gtgggtggct gacccccagc atcctcggga gcgacc atg gac tcc ctg gcc gag         54
                                        Met Asp Ser Leu Ala Glu           
                                        1               5                 

tct cgg tgg cct ccg ggc ctg gca gtc atg aag aca ata gat gat ttg        102
Ser Arg Trp Pro Pro Gly Leu Ala Val Met Lys Thr Ile Asp Asp Leu           
            10                  15                  20                    

ctg cgg tgt gga att tgc ttc gag tat ttc aac att gca atg ata ata        150
Leu Arg Cys Gly Ile Cys Phe Glu Tyr Phe Asn Ile Ala Met Ile Ile           
        25                  30                  35                        

cct cag tgt tca cat aac tac tgc tct ctc tgt ata aga aaa ttt ctg        198
Pro Gln Cys Ser His Asn Tyr Cys Ser Leu Cys Ile Arg Lys Phe Leu           
    40                  45                  50                            

tcc tat aaa act cag tgt cca act tgc tgt gtg act gtc aca gag ccg        246
Ser Tyr Lys Thr Gln Cys Pro Thr Cys Cys Val Thr Val Thr Glu Pro           
55                  60                  65                  70            

gat ctg aaa aat aac cgc ata tta gat gaa ctg gta aaa agc ttg aat        294
Asp Leu Lys Asn Asn Arg Ile Leu Asp Glu Leu Val Lys Ser Leu Asn           
                75                  80                  85                

ttt gca cgg aat cat ctg ctg cag ttt gct tta gag tca cca gcc aaa        342
Phe Ala Arg Asn His Leu Leu Gln Phe Ala Leu Glu Ser Pro Ala Lys           
            90                  95                  100                   

tct cct gct tct tcc tct tca aag aat ctt gct gtc aaa gta tat act        390
Ser Pro Ala Ser Ser Ser Ser Lys Asn Leu Ala Val Lys Val Tyr Thr           
        105                 110                 115                       

cct gta gcc tcc aga cag tct tta aag cag ggg agc agg tta atg gat        438
Pro Val Ala Ser Arg Gln Ser Leu Lys Gln Gly Ser Arg Leu Met Asp           
    120                 125                 130                           

aat ttc ttg atc aga gaa atg agt ggt tct aca tca gag ttg ttg ata        486
Asn Phe Leu Ile Arg Glu Met Ser Gly Ser Thr Ser Glu Leu Leu Ile           
135                 140                 145                 150           

aaa gaa aat aaa agc aaa ttc agc cct caa aaa gag gcg agc cct gct        534
Lys Glu Asn Lys Ser Lys Phe Ser Pro Gln Lys Glu Ala Ser Pro Ala           
                155                 160                 165               

gca aag acc aaa gag aca cgt tct gta gaa gag atc gct cca gat ccc        582
Ala Lys Thr Lys Glu Thr Arg Ser Val Glu Glu Ile Ala Pro Asp Pro           
            170                 175                 180                   

tca gag gct aag cgt cct gag cca ccc tcg aca tcc act ttg aaa caa        630
Ser Glu Ala Lys Arg Pro Glu Pro Pro Ser Thr Ser Thr Leu Lys Gln           
        185                 190                 195                       

gtt act aaa gtg gat tgt cct gtt tgc ggg gtt aac att cca gaa agt        678
Val Thr Lys Val Asp Cys Pro Val Cys Gly Val Asn Ile Pro Glu Ser           
    200                 205                 210                           

cac att aat aag cat tta gac agc tgt tta tca cgc gaa gag aag aag        726
His Ile Asn Lys His Leu Asp Ser Cys Leu Ser Arg Glu Glu Lys Lys           
215                 220                 225                 230           

gaa agc ctc aga agt tct gtt cac aaa agg aag ccg ctg ccc aaa act        774
Glu Ser Leu Arg Ser Ser Val His Lys Arg Lys Pro Leu Pro Lys Thr           
                235                 240                 245               

gta tat aat ttg ctc tct gat cgt gat tta aag aaa aag cta aaa gag        822
Val Tyr Asn Leu Leu Ser Asp Arg Asp Leu Lys Lys Lys Leu Lys Glu           
            250                 255                 260                   

cat gga tta tct att caa gga aat aaa caa cag ctc att aaa agg cac        870
His Gly Leu Ser Ile Gln Gly Asn Lys Gln Gln Leu Ile Lys Arg His           
        265                 270                 275                       

caa gaa ttt gta cac atg tac aat gcc caa tgc gat gct ttg cat cct        918
Gln Glu Phe Val His Met Tyr Asn Ala Gln Cys Asp Ala Leu His Pro           
    280                 285                 290                           

aaa tca gct gct gaa ata gtt caa gaa atc gaa aat ata gag aag act        966
Lys Ser Ala Ala Glu Ile Val Gln Glu Ile Glu Asn Ile Glu Lys Thr           
295                 300                 305                 310           

agg atg cgt ctt gaa gct agt aaa ctc aat gaa agt gta atg gtt ttt       1014
Arg Met Arg Leu Glu Ala Ser Lys Leu Asn Glu Ser Val Met Val Phe           
                315                 320                 325               

aca aag gac caa aca gaa aag gaa ata gat gaa atc cac agt aaa tat       1062
Thr Lys Asp Gln Thr Glu Lys Glu Ile Asp Glu Ile His Ser Lys Tyr           
            330                 335                 340                   

cgt aaa aaa cat aag agt gaa ttt cag ctt ctg gtg gat cag gct aga       1110
Arg Lys Lys His Lys Ser Glu Phe Gln Leu Leu Val Asp Gln Ala Arg           
        345                 350                 355                       

aaa gga tac aag aaa att gct gga atg tca caa aaa aca gta aca ata       1158
Lys Gly Tyr Lys Lys Ile Ala Gly Met Ser Gln Lys Thr Val Thr Ile           
    360                 365                 370                           

aca aaa gaa gat gaa tct aca gaa aag cta tct tct gta tgc atg gga       1206
Thr Lys Glu Asp Glu Ser Thr Glu Lys Leu Ser Ser Val Cys Met Gly           
375                 380                 385                 390           

cag gaa gat aat atg acc tca gta aca aac cac ttt tct caa tca aag       1254
Gln Glu Asp Asn Met Thr Ser Val Thr Asn His Phe Ser Gln Ser Lys           
                395                 400                 405               

ctg gac tcc cca gag gaa ttg gaa cct gac aga gaa gag gat tct tct       1302
Leu Asp Ser Pro Glu Glu Leu Glu Pro Asp Arg Glu Glu Asp Ser Ser           
            410                 415                 420                   

agc tgt att gat att caa gaa gtt ctt tct tca tca gaa tca gat tca       1350
Ser Cys Ile Asp Ile Gln Glu Val Leu Ser Ser Ser Glu Ser Asp Ser           
        425                 430                 435                       

tgc aat agt tcc agt tca gac atc ata aga gat ctt tta gaa gaa gag       1398
Cys Asn Ser Ser Ser Ser Asp Ile Ile Arg Asp Leu Leu Glu Glu Glu           
    440                 445                 450                           

gaa gcc tgg gaa gca tca cat aaa aac gat ctt caa gac aca gaa ata       1446
Glu Ala Trp Glu Ala Ser His Lys Asn Asp Leu Gln Asp Thr Glu Ile           
455                 460                 465                 470           

agt cca aga cag aat cgc cgc aca aga gcc gct gaa agt gct gag att       1494
Ser Pro Arg Gln Asn Arg Arg Thr Arg Ala Ala Glu Ser Ala Glu Ile           
                475                 480                 485               

gaa cca aga aac aag cgt aat agg aat taa tgtgggcttt tgctgacttt         1544
Glu Pro Arg Asn Lys Arg Asn Arg Asn                                       
            490                 495                                       

tcaaatgcat tgattagaat accgtacttt tggttgccac agatagattt tctatttata     1604

aatgcccaag gaaagatgct aaattctaaa tattacggtt agctgataaa aaaaaaaaaa     1664

aaaaa                                                                 1669


<210>  2
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Ser Leu Ala Glu Ser Arg Trp Pro Pro Gly Leu Ala Val Met 
1               5                   10                  15      


Lys Thr Ile Asp Asp Leu Leu Arg Cys Gly Ile Cys Phe Glu Tyr Phe 
            20                  25                  30          


Asn Ile Ala Met Ile Ile Pro Gln Cys Ser His Asn Tyr Cys Ser Leu 
        35                  40                  45              


Cys Ile Arg Lys Phe Leu Ser Tyr Lys Thr Gln Cys Pro Thr Cys Cys 
    50                  55                  60                  


Val Thr Val Thr Glu Pro Asp Leu Lys Asn Asn Arg Ile Leu Asp Glu 
65                  70                  75                  80  


Leu Val Lys Ser Leu Asn Phe Ala Arg Asn His Leu Leu Gln Phe Ala 
                85                  90                  95      


Leu Glu Ser Pro Ala Lys Ser Pro Ala Ser Ser Ser Ser Lys Asn Leu 
            100                 105                 110         


Ala Val Lys Val Tyr Thr Pro Val Ala Ser Arg Gln Ser Leu Lys Gln 
        115                 120                 125             


Gly Ser Arg Leu Met Asp Asn Phe Leu Ile Arg Glu Met Ser Gly Ser 
    130                 135                 140                 


Thr Ser Glu Leu Leu Ile Lys Glu Asn Lys Ser Lys Phe Ser Pro Gln 
145                 150                 155                 160 


Lys Glu Ala Ser Pro Ala Ala Lys Thr Lys Glu Thr Arg Ser Val Glu 
                165                 170                 175     


Glu Ile Ala Pro Asp Pro Ser Glu Ala Lys Arg Pro Glu Pro Pro Ser 
            180                 185                 190         


Thr Ser Thr Leu Lys Gln Val Thr Lys Val Asp Cys Pro Val Cys Gly 
        195                 200                 205             


Val Asn Ile Pro Glu Ser His Ile Asn Lys His Leu Asp Ser Cys Leu 
    210                 215                 220                 


Ser Arg Glu Glu Lys Lys Glu Ser Leu Arg Ser Ser Val His Lys Arg 
225                 230                 235                 240 


Lys Pro Leu Pro Lys Thr Val Tyr Asn Leu Leu Ser Asp Arg Asp Leu 
                245                 250                 255     


Lys Lys Lys Leu Lys Glu His Gly Leu Ser Ile Gln Gly Asn Lys Gln 
            260                 265                 270         


Gln Leu Ile Lys Arg His Gln Glu Phe Val His Met Tyr Asn Ala Gln 
        275                 280                 285             


Cys Asp Ala Leu His Pro Lys Ser Ala Ala Glu Ile Val Gln Glu Ile 
    290                 295                 300                 


Glu Asn Ile Glu Lys Thr Arg Met Arg Leu Glu Ala Ser Lys Leu Asn 
305                 310                 315                 320 


Glu Ser Val Met Val Phe Thr Lys Asp Gln Thr Glu Lys Glu Ile Asp 
                325                 330                 335     


Glu Ile His Ser Lys Tyr Arg Lys Lys His Lys Ser Glu Phe Gln Leu 
            340                 345                 350         


Leu Val Asp Gln Ala Arg Lys Gly Tyr Lys Lys Ile Ala Gly Met Ser 
        355                 360                 365             


Gln Lys Thr Val Thr Ile Thr Lys Glu Asp Glu Ser Thr Glu Lys Leu 
    370                 375                 380                 


Ser Ser Val Cys Met Gly Gln Glu Asp Asn Met Thr Ser Val Thr Asn 
385                 390                 395                 400 


His Phe Ser Gln Ser Lys Leu Asp Ser Pro Glu Glu Leu Glu Pro Asp 
                405                 410                 415     


Arg Glu Glu Asp Ser Ser Ser Cys Ile Asp Ile Gln Glu Val Leu Ser 
            420                 425                 430         


Ser Ser Glu Ser Asp Ser Cys Asn Ser Ser Ser Ser Asp Ile Ile Arg 
        435                 440                 445             


Asp Leu Leu Glu Glu Glu Glu Ala Trp Glu Ala Ser His Lys Asn Asp 
    450                 455                 460                 


Leu Gln Asp Thr Glu Ile Ser Pro Arg Gln Asn Arg Arg Thr Arg Ala 
465                 470                 475                 480 


Ala Glu Ser Ala Glu Ile Glu Pro Arg Asn Lys Arg Asn Arg Asn 
                485                 490                 495 


<210>  3
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  3
gaggauucuu cuagcugua                                                    19


