                         SEQUENCE LISTING

<110>  Universitt Zrich
 
<120>  Directed evolution of membrane proteins in eukaryotic cells with 
       a cell wall

<130>  uz231wo

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fwd primer for error prone PCR

<400>  1
ctaaagaaga aggggtatct ctcgagaaac gtgaggcgga agcggctagc                  50


<210>  2
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for error prone PCR

<400>  2
attacatgac tcgactcgat gccgacgaga gcggccgcct attaggatcc                  50


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  labelled Neurotensin


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  labelled with HiLyte Fluor 488

<400>  3

Lys Lys Pro Tyr Ile Leu 
1               5       


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substance P from Homo sapiens modified


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  labeled with HiLyte Fluor 488

<400>  4

Arg Pro Lys Pro Gln Gln Phe Phe Gly Leu Met 
1               5                   10      


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dynorphin A from homo sapiens modified


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  labeled with HiLyte Fluor 488

<400>  5

Tyr Gly Gly Phe Leu Arg Arg Ile Arg Pro Lys 
1               5                   10      


<210>  6
<211>  424
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Met His Leu Asn Ser Ser Val Pro Gln Gly Thr Pro Gly Glu Pro Asp 
1               5                   10                  15      


Ala Gln Pro Phe Ser Gly Pro Gln Ser Glu Met Glu Ala Thr Phe Leu 
            20                  25                  30          


Ala Leu Ser Leu Ser Asn Gly Ser Gly Asn Thr Ser Glu Ser Asp Thr 
        35                  40                  45              


Ala Gly Pro Asn Ser Asp Leu Asp Val Asn Thr Asp Ile Tyr Ser Lys 
    50                  55                  60                  


Val Leu Val Thr Ala Ile Tyr Leu Ala Leu Phe Val Val Gly Thr Val 
65                  70                  75                  80  


Gly Asn Ser Val Thr Ala Phe Thr Leu Ala Arg Lys Lys Ser Leu Gln 
                85                  90                  95      


Ser Leu Gln Ser Thr Val His Tyr His Leu Gly Ser Leu Ala Leu Ser 
            100                 105                 110         


Asp Leu Leu Ile Leu Leu Leu Ala Met Pro Val Glu Leu Tyr Asn Phe 
        115                 120                 125             


Ile Trp Val His His Pro Trp Ala Phe Gly Asp Ala Gly Cys Arg Gly 
    130                 135                 140                 


Tyr Tyr Phe Leu Arg Asp Ala Cys Thr Tyr Ala Thr Ala Leu Asn Val 
145                 150                 155                 160 


Ala Ser Leu Ser Val Glu Arg Tyr Leu Ala Ile Cys His Pro Phe Lys 
                165                 170                 175     


Ala Lys Thr Leu Met Ser Arg Ser Arg Thr Lys Lys Phe Ile Ser Ala 
            180                 185                 190         


Ile Trp Leu Ala Ser Ala Leu Leu Ala Ile Pro Met Leu Phe Thr Met 
        195                 200                 205             


Gly Leu Gln Asn Arg Ser Gly Asp Gly Thr His Pro Gly Gly Leu Val 
    210                 215                 220                 


Cys Thr Pro Ile Val Asp Thr Ala Thr Val Lys Val Val Ile Gln Val 
225                 230                 235                 240 


Asn Thr Phe Met Ser Phe Leu Phe Pro Met Leu Val Ile Ser Ile Leu 
                245                 250                 255     


Asn Thr Val Ile Ala Asn Lys Leu Thr Val Met Val His Gln Ala Ala 
            260                 265                 270         


Glu Gln Gly Arg Val Cys Thr Val Gly Thr His Asn Gly Leu Glu His 
        275                 280                 285             


Ser Thr Phe Asn Met Thr Ile Glu Pro Gly Arg Val Gln Ala Leu Arg 
    290                 295                 300                 


His Gly Val Leu Val Leu Arg Ala Val Val Ile Ala Phe Val Val Cys 
305                 310                 315                 320 


Trp Leu Pro Tyr His Val Arg Arg Leu Met Phe Cys Tyr Ile Ser Asp 
                325                 330                 335     


Glu Gln Trp Thr Thr Phe Leu Phe Asp Phe Tyr His Tyr Phe Tyr Met 
            340                 345                 350         


Leu Thr Asn Ala Leu Phe Tyr Val Ser Ser Ala Ile Asn Pro Ile Leu 
        355                 360                 365             


Tyr Asn Leu Val Ser Ala Asn Phe Arg Gln Val Phe Leu Ser Thr Leu 
    370                 375                 380                 


Ala Cys Leu Cys Pro Gly Trp Arg His Arg Arg Lys Lys Arg Pro Thr 
385                 390                 395                 400 


Phe Ser Arg Lys Pro Asn Ser Met Ser Ser Asn His Ala Phe Ser Thr 
                405                 410                 415     


Ser Ala Thr Arg Glu Thr Leu Tyr 
            420                 


<210>  7
<211>  424
<212>  PRT
<213>  Rattus norvegicus

<400>  7

Met His Leu Asn Ser Ser Val Pro Gln Gly Thr Pro Gly Glu Pro Asp 
1               5                   10                  15      


Ala Gln Pro Phe Ser Gly Pro Gln Ser Glu Met Glu Ala Thr Phe Leu 
            20                  25                  30          


Ala Leu Ser Leu Ser Asn Gly Ser Gly Asn Thr Ser Glu Ser Asp Thr 
        35                  40                  45              


Pro Gly Pro Asn Ser Asp Leu Asp Val Asn Thr Asp Ile Tyr Ser Lys 
    50                  55                  60                  


Val Leu Val Thr Ala Ile Tyr Leu Ala Leu Phe Val Val Gly Thr Val 
65                  70                  75                  80  


Gly Asn Ser Val Thr Ala Phe Thr Leu Ala Arg Lys Lys Ser Leu Gln 
                85                  90                  95      


Ser Leu Gln Ser Thr Val His Tyr His Leu Gly Ser Leu Ala Leu Ser 
            100                 105                 110         


Asn Leu Leu Ile Leu Leu Leu Ala Met Pro Val Glu Leu Tyr Asn Phe 
        115                 120                 125             


Ile Trp Val His His Pro Trp Ala Phe Gly Asp Ala Gly Cys Arg Gly 
    130                 135                 140                 


Tyr Tyr Phe Leu Arg Asp Ala Cys Thr Tyr Ala Thr Ala Leu Asn Val 
145                 150                 155                 160 


Ala Ser Leu Ser Val Glu Arg Tyr Leu Ala Ile Cys His Pro Phe Lys 
                165                 170                 175     


Ala Lys Thr Leu Met Ser Arg Ser Arg Thr Lys Lys Phe Ile Ser Ala 
            180                 185                 190         


Ile Trp Leu Ala Ser Ala Leu Leu Ala Ile Pro Met Leu Phe Thr Met 
        195                 200                 205             


Gly Leu Gln Asn Arg Ser Gly Asp Gly Thr His Pro Gly Gly Leu Val 
    210                 215                 220                 


Cys Thr Pro Ile Val Asp Thr Ala Thr Val Lys Val Val Ile Gln Val 
225                 230                 235                 240 


Asn Thr Phe Met Ser Phe Leu Phe Pro Met Leu Val Ile Ser Ile Leu 
                245                 250                 255     


Asn Thr Val Ile Ser Asn Lys Leu Thr Val Met Val His Gln Ala Ala 
            260                 265                 270         


Glu Gln Gly Arg Val Cys Thr Val Gly Thr His Asn Gly Leu Glu His 
        275                 280                 285             


Ser Thr Phe Asn Met Thr Ile Glu Pro Gly Arg Val Gln Ala Leu Arg 
    290                 295                 300                 


His Gly Val Leu Val Leu Arg Ala Val Val Ile Ala Phe Val Val Cys 
305                 310                 315                 320 


Trp Leu Pro Tyr His Val Arg Arg Leu Met Phe Cys Tyr Ile Ser Asp 
                325                 330                 335     


Glu Gln Trp Thr Thr Phe Leu Phe Asp Phe Tyr His Tyr Phe Tyr Met 
            340                 345                 350         


Leu Thr Asn Ser Leu Phe Tyr Val Ser Ser Ala Ile Asn Pro Ile Leu 
        355                 360                 365             


Tyr Asn Leu Val Ser Ala Asn Phe Arg Gln Val Phe Leu Ser Thr Leu 
    370                 375                 380                 


Ala Cys Leu Cys Pro Gly Trp Arg His Arg Arg Lys Lys Arg Pro Thr 
385                 390                 395                 400 


Phe Ser Arg Lys Pro Asn Ser Met Ser Ser Asn His Ala Phe Ser Thr 
                405                 410                 415     


Ser Ala Thr Arg Glu Thr Leu Tyr 
            420                 


<210>  8
<211>  424
<212>  PRT
<213>  Rattus norvegicus

<400>  8

Met His Leu Asn Ser Ser Val Pro Gln Gly Thr Pro Gly Glu Pro Asp 
1               5                   10                  15      


Ala Gln Pro Phe Ser Gly Pro Gln Ser Glu Met Glu Ala Thr Phe Leu 
            20                  25                  30          


Ala Leu Ser Leu Ser Asn Gly Ser Gly Asn Thr Ser Glu Ser Asp Thr 
        35                  40                  45              


Pro Gly Pro Asn Ser Asp Leu Asp Val Asn Thr Asp Ile Tyr Ser Lys 
    50                  55                  60                  


Val Leu Val Thr Ala Ile Tyr Leu Ala Leu Phe Val Val Gly Thr Val 
65                  70                  75                  80  


Gly Asn Ser Val Thr Ala Phe Thr Leu Ala Arg Lys Lys Ser Leu Gln 
                85                  90                  95      


Ser Leu Gln Ser Thr Val His Tyr His Leu Gly Ser Leu Ala Leu Ser 
            100                 105                 110         


Asn Leu Leu Ile Leu Leu Leu Ala Met Pro Val Glu Leu Tyr Asn Phe 
        115                 120                 125             


Ile Trp Val His His Pro Trp Ala Phe Gly Asp Ala Gly Cys Arg Gly 
    130                 135                 140                 


Tyr Tyr Phe Leu Arg Asp Ala Cys Thr Tyr Ala Thr Ala Leu Asn Val 
145                 150                 155                 160 


Ala Ser Leu Ser Val Glu Arg Tyr Leu Ala Ile Cys His Pro Phe Lys 
                165                 170                 175     


Ala Lys Thr Leu Met Ser Arg Ser Arg Thr Lys Lys Phe Ile Ser Ala 
            180                 185                 190         


Ile Trp Leu Ala Ser Ala Leu Leu Ala Ile Pro Met Leu Phe Thr Met 
        195                 200                 205             


Gly Leu Gln Asn Arg Ser Gly Asp Gly Thr His Pro Gly Gly Leu Val 
    210                 215                 220                 


Cys Thr Pro Ile Val Asp Thr Ala Thr Val Lys Val Val Ile Gln Val 
225                 230                 235                 240 


Asn Thr Phe Met Ser Phe Leu Leu Pro Met Leu Val Ile Ser Ile Leu 
                245                 250                 255     


Asn Thr Val Ile Ser Asn Lys Leu Thr Val Met Val His Gln Ala Ala 
            260                 265                 270         


Glu Gln Gly Arg Val Cys Thr Ala Gly Thr His Asn Gly Leu Glu His 
        275                 280                 285             


Ser Thr Phe Asn Met Thr Ile Glu Pro Gly Arg Val Gln Ala Leu Arg 
    290                 295                 300                 


His Gly Val Leu Val Leu Arg Ala Val Val Ile Ala Phe Val Val Cys 
305                 310                 315                 320 


Trp Leu Pro Tyr His Val Arg Arg Leu Met Phe Cys Tyr Ile Ser Asp 
                325                 330                 335     


Glu Gln Trp Thr Thr Phe Leu Phe Asp Phe Tyr His Tyr Phe Tyr Met 
            340                 345                 350         


Leu Thr Asn Ser Leu Phe Tyr Val Ser Ser Ala Ile Asn Pro Ile Leu 
        355                 360                 365             


Tyr Asn Leu Val Ser Ala Asn Phe Arg Gln Val Phe Leu Ser Thr Leu 
    370                 375                 380                 


Ala Cys Leu Cys Pro Gly Trp Arg His Arg Arg Lys Lys Arg Pro Thr 
385                 390                 395                 400 


Phe Ser Arg Lys Pro Asn Ser Met Ser Ser Asn His Ala Phe Ser Thr 
                405                 410                 415     


Ser Ala Thr Arg Glu Thr Leu Tyr 
            420                 


<210>  9
<211>  424
<212>  PRT
<213>  Rattus norvegicus

<400>  9

Met His Leu Asn Ser Ser Val Pro Gln Gly Thr Pro Gly Glu Pro Asp 
1               5                   10                  15      


Ala Gln Pro Phe Ser Gly Pro Gln Ser Glu Met Glu Ala Thr Phe Leu 
            20                  25                  30          


Ala Leu Ser Leu Ser Asn Gly Ser Gly Asn Thr Ser Glu Ser Asp Thr 
        35                  40                  45              


Ala Gly Pro Asn Ser Asp Leu Asp Val Asn Thr Asp Ile Tyr Ser Lys 
    50                  55                  60                  


Val Leu Val Thr Ala Ile Tyr Leu Ala Leu Phe Val Val Gly Thr Val 
65                  70                  75                  80  


Gly Asn Ser Val Thr Ala Phe Thr Leu Ala Arg Lys Lys Ser Leu Gln 
                85                  90                  95      


Ser Leu Gln Ser Thr Val His Tyr His Leu Gly Ser Leu Ala Leu Ser 
            100                 105                 110         


Asp Leu Leu Ile Leu Leu Leu Ala Met Pro Val Glu Leu Tyr Asn Phe 
        115                 120                 125             


Ile Trp Val His His Pro Trp Ala Phe Gly Asp Ala Gly Cys Arg Gly 
    130                 135                 140                 


Tyr Tyr Phe Leu Arg Asp Ala Cys Thr Tyr Ala Thr Ala Leu Asn Val 
145                 150                 155                 160 


Ala Ser Leu Ser Val Glu Arg Tyr Leu Ala Ile Cys His Pro Phe Lys 
                165                 170                 175     


Ala Lys Thr Leu Met Ser Arg Ser Arg Thr Lys Lys Phe Ile Ser Ala 
            180                 185                 190         


Ile Trp Leu Ala Ser Ala Leu Leu Ala Ile Pro Met Leu Phe Thr Met 
        195                 200                 205             


Gly Leu Gln Asn Arg Ser Gly Asp Gly Thr His Pro Gly Gly Leu Val 
    210                 215                 220                 


Cys Thr Pro Ile Val Asp Thr Ala Thr Val Lys Val Val Ile Gln Val 
225                 230                 235                 240 


Asn Thr Phe Met Ser Phe Leu Phe Pro Met Leu Val Ile Ser Ile Leu 
                245                 250                 255     


Asn Thr Val Ile Ala Asn Lys Leu Thr Val Met Val His Gln Ala Ala 
            260                 265                 270         


Glu Gln Gly Arg Val Cys Thr Val Gly Thr His Asn Gly Leu Glu His 
        275                 280                 285             


Ser Thr Phe Asn Met Thr Ile Glu Pro Gly Arg Val Gln Ala Leu Arg 
    290                 295                 300                 


His Gly Val Leu Val Leu Arg Ala Val Val Ile Ala Phe Val Val Cys 
305                 310                 315                 320 


Trp Leu Pro Tyr His Val Arg Arg Leu Met Phe Cys Tyr Ile Ser Asp 
                325                 330                 335     


Glu Gln Trp Thr Thr Phe Leu Phe Asp Phe Tyr His Tyr Phe Tyr Met 
            340                 345                 350         


Leu Thr Asn Ala Leu Phe Tyr Val Ser Ser Ala Ile Asn Pro Ile Leu 
        355                 360                 365             


Tyr Asn Leu Val Ser Ala Asn Phe Arg Gln Val Phe Leu Ser Thr Leu 
    370                 375                 380                 


Ala Cys Leu Cys Pro Gly Trp Arg His Arg Arg Lys Lys Arg Pro Thr 
385                 390                 395                 400 


Phe Ser Arg Lys Pro Asn Ser Met Ser Ser Asn His Ala Phe Ser Thr 
                405                 410                 415     


Ser Ala Thr Arg Glu Thr Leu Tyr 
            420                 


<210>  10
<211>  424
<212>  PRT
<213>  Rattus norvegicus

<400>  10

Met His Leu Asn Ser Ser Val Pro Gln Gly Thr Pro Gly Glu Pro Asp 
1               5                   10                  15      


Ala Gln Pro Phe Ser Gly Pro Gln Ser Glu Met Glu Ala Thr Phe Leu 
            20                  25                  30          


Ala Leu Ser Leu Ser Asn Gly Ser Gly Asn Thr Ser Glu Ser Asp Thr 
        35                  40                  45              


Pro Gly Pro Asn Ser Asp Leu Asp Val Asn Thr Asp Ile Tyr Ser Lys 
    50                  55                  60                  


Val Leu Val Thr Ala Ile Tyr Leu Ala Leu Phe Val Val Gly Thr Val 
65                  70                  75                  80  


Gly Asn Ser Val Thr Ala Phe Thr Leu Ala Arg Lys Lys Ser Leu Gln 
                85                  90                  95      


Ser Leu Gln Ser Thr Val His Tyr His Leu Gly Ser Leu Ala Leu Ser 
            100                 105                 110         


Asn Leu Leu Ile Leu Leu Leu Ala Met Pro Val Glu Leu Tyr Asn Phe 
        115                 120                 125             


Ile Trp Val His His Pro Trp Ala Phe Gly Asp Ala Gly Cys Arg Gly 
    130                 135                 140                 


Tyr Tyr Phe Leu Arg Asp Ala Cys Thr Tyr Ala Thr Ala Leu Asn Val 
145                 150                 155                 160 


Ala Ser Leu Ser Val Glu Arg Tyr Leu Ala Ile Cys His Pro Phe Lys 
                165                 170                 175     


Ala Lys Thr Leu Met Ser Arg Ser Arg Thr Lys Lys Phe Ile Ser Ala 
            180                 185                 190         


Ile Trp Leu Ala Ser Ala Leu Leu Ala Ile Pro Met Leu Phe Thr Met 
        195                 200                 205             


Gly Leu Gln Asn Arg Ser Gly Asp Gly Thr His Pro Gly Gly Leu Val 
    210                 215                 220                 


Cys Thr Pro Ile Val Asp Thr Ala Thr Val Lys Val Val Ile Gln Val 
225                 230                 235                 240 


Asn Thr Phe Met Ser Phe Leu Phe Pro Met Leu Val Ile Ser Ile Leu 
                245                 250                 255     


Asn Thr Val Ile Ser Asn Lys Leu Thr Val Met Val His Gln Ala Ala 
            260                 265                 270         


Glu Gln Gly Arg Val Cys Thr Val Gly Thr His Asn Gly Leu Glu His 
        275                 280                 285             


Ser Thr Phe Asn Met Thr Ile Glu Pro Gly Arg Val Gln Ala Leu Arg 
    290                 295                 300                 


His Gly Val Leu Val Leu Arg Ala Val Val Ile Ala Phe Val Val Cys 
305                 310                 315                 320 


Trp Leu Pro Tyr His Val Arg Arg Leu Met Phe Cys Tyr Ile Ser Asp 
                325                 330                 335     


Glu Gln Trp Thr Thr Phe Leu Phe Asp Phe Tyr His Tyr Phe Tyr Met 
            340                 345                 350         


Leu Thr Asn Ser Leu Phe Tyr Val Ser Ser Ala Ile Asn Pro Ile Leu 
        355                 360                 365             


Tyr Asn Leu Val Ser Ala Asn Phe Arg Gln Val Phe Leu Ser Thr Leu 
    370                 375                 380                 


Ala Cys Leu Cys Pro Gly Trp Arg His Arg Arg Lys Lys Trp Pro Thr 
385                 390                 395                 400 


Phe Ser Arg Lys Pro Asn Ser Met Ser Ser Asn His Ala Phe Ser Thr 
                405                 410                 415     


Ser Ala Thr Arg Glu Thr Leu Tyr 
            420                 


<210>  11
<211>  424
<212>  PRT
<213>  Rattus norvegicus

<400>  11

Met His Leu Asn Ser Ser Val Pro Gln Gly Thr Pro Gly Glu Pro Asp 
1               5                   10                  15      


Ala Gln Pro Phe Ser Gly Pro Gln Ser Glu Met Glu Ala Thr Phe Leu 
            20                  25                  30          


Ala Leu Ser Leu Ser Asn Gly Ser Gly Asn Thr Ser Glu Ser Asp Thr 
        35                  40                  45              


Pro Gly Pro Asn Ser Asp Leu Asp Val Asn Thr Asp Ile Tyr Ser Lys 
    50                  55                  60                  


Val Leu Val Thr Ala Ile Tyr Leu Ala Leu Phe Val Val Gly Thr Val 
65                  70                  75                  80  


Gly Asn Ser Val Thr Ala Phe Thr Leu Ala Arg Lys Lys Ser Leu Gln 
                85                  90                  95      


Ser Leu Gln Ser Thr Val His Tyr His Leu Gly Ser Leu Ala Leu Ser 
            100                 105                 110         


Asn Leu Leu Ile Leu Leu Leu Ala Met Pro Val Glu Leu Tyr Asn Phe 
        115                 120                 125             


Ile Trp Val His His Pro Trp Ala Phe Gly Asp Ala Gly Cys Arg Gly 
    130                 135                 140                 


Tyr Tyr Phe Leu Arg Asp Ala Cys Thr Tyr Ala Thr Ala Leu Asn Val 
145                 150                 155                 160 


Ala Ser Leu Ser Val Glu Arg Tyr Leu Ala Ile Cys His Pro Phe Lys 
                165                 170                 175     


Ala Lys Thr Leu Met Ser Arg Ser Arg Thr Lys Lys Phe Ile Ser Ala 
            180                 185                 190         


Ile Trp Leu Ala Ser Ala Leu Leu Ala Ile Pro Met Leu Phe Thr Met 
        195                 200                 205             


Gly Leu Gln Asn Arg Ser Gly Asp Gly Thr His Pro Gly Gly Leu Val 
    210                 215                 220                 


Cys Thr Pro Ile Val Asp Thr Ala Thr Val Lys Val Val Ile Gln Val 
225                 230                 235                 240 


Asn Thr Phe Met Ser Phe Leu Phe Pro Met Leu Val Ile Ser Ile Leu 
                245                 250                 255     


Asn Thr Val Ile Ser Asn Lys Leu Thr Val Met Val His Gln Ala Ala 
            260                 265                 270         


Glu Gln Gly Arg Val Cys Thr Val Gly Thr His Asn Gly Leu Glu His 
        275                 280                 285             


Ser Thr Phe Asn Met Thr Ile Glu Pro Gly Arg Val Gln Ala Leu Arg 
    290                 295                 300                 


His Gly Val Leu Val Leu Arg Ala Val Val Ile Ala Phe Val Val Cys 
305                 310                 315                 320 


Trp Leu Pro Tyr His Val Arg Arg Leu Met Phe Cys Tyr Ile Ser Asp 
                325                 330                 335     


Glu Gln Trp Thr Thr Phe Leu Phe Asp Phe Tyr His Tyr Phe Tyr Met 
            340                 345                 350         


Leu Thr Asn Ser Leu Phe Tyr Val Ser Ser Ala Ile Asn Pro Ile Leu 
        355                 360                 365             


Tyr Asn Leu Val Ser Ala Asn Phe Arg Gln Val Phe Leu Ser Thr Leu 
    370                 375                 380                 


Ala Gly Leu Cys Pro Gly Trp Cys His Arg Arg Lys Lys Arg Pro Thr 
385                 390                 395                 400 


Phe Ser Arg Lys Pro Asn Ser Met Ser Ser Asn His Ala Phe Ser Thr 
                405                 410                 415     


Ser Ala Thr Arg Glu Thr Leu Tyr 
            420                 


<210>  12
<211>  424
<212>  PRT
<213>  Rattus norvegicus

<400>  12

Met His Leu Asn Ser Ser Val Pro Gln Gly Thr Pro Gly Glu Pro Asp 
1               5                   10                  15      


Ala Gln Pro Phe Ser Gly Pro Gln Ser Glu Met Glu Ala Thr Phe Leu 
            20                  25                  30          


Ala Leu Ser Leu Ser Asn Gly Ser Gly Asn Thr Ser Glu Ser Asp Thr 
        35                  40                  45              


Pro Gly Pro Asn Ser Asp Leu Asp Val Asn Thr Asp Ile Tyr Ser Lys 
    50                  55                  60                  


Val Leu Val Thr Ala Ile Tyr Leu Ala Leu Phe Val Val Gly Thr Val 
65                  70                  75                  80  


Gly Asn Ser Val Thr Ala Phe Thr Leu Ala Arg Lys Lys Ser Leu Gln 
                85                  90                  95      


Ser Leu Gln Ser Thr Val His Tyr His Leu Gly Ser Leu Ala Leu Ser 
            100                 105                 110         


Asn Leu Leu Ile Leu Leu Leu Ala Met Pro Val Glu Leu Tyr Asn Phe 
        115                 120                 125             


Ile Trp Val His His Pro Trp Ala Phe Gly Asp Ala Gly Cys Arg Gly 
    130                 135                 140                 


Tyr Tyr Phe Leu Arg Asp Ala Cys Thr Tyr Ala Thr Ala Leu Asn Val 
145                 150                 155                 160 


Ala Ser Leu Ser Val Glu Arg Tyr Leu Ala Ile Cys His Pro Phe Lys 
                165                 170                 175     


Ala Lys Thr Leu Met Ser Arg Ser Arg Thr Lys Lys Phe Ile Ser Ala 
            180                 185                 190         


Ile Trp Leu Ala Ser Ala Leu Leu Ala Ile Pro Met Leu Phe Thr Met 
        195                 200                 205             


Gly Leu Gln Asn Arg Ser Gly Asp Gly Thr His Pro Gly Gly Leu Val 
    210                 215                 220                 


Cys Thr Pro Ile Val Asp Thr Ala Thr Val Lys Val Val Ile Gln Val 
225                 230                 235                 240 


Asn Thr Phe Met Ser Phe Leu Phe Pro Met Leu Val Ile Ser Ile Leu 
                245                 250                 255     


Ser Thr Val Ile Ser Asn Lys Leu Thr Val Met Val His Gln Ala Ala 
            260                 265                 270         


Glu Gln Gly Arg Val Cys Thr Val Gly Thr His Asp Gly Leu Glu His 
        275                 280                 285             


Ser Thr Phe Asn Met Thr Ile Glu Pro Gly Arg Val Gln Ala Leu Arg 
    290                 295                 300                 


His Gly Val Leu Val Leu Arg Ala Val Val Ile Ala Phe Val Val Cys 
305                 310                 315                 320 


Trp Leu Pro Tyr His Val Arg Arg Leu Met Phe Cys Tyr Ile Ser Asp 
                325                 330                 335     


Glu Gln Trp Thr Thr Phe Leu Phe Asp Phe Tyr His Tyr Phe Tyr Met 
            340                 345                 350         


Leu Thr Asn Thr Leu Leu Tyr Val Ser Ser Thr Ile Asn Pro Ile Leu 
        355                 360                 365             


Tyr Ile Leu Val Ser Ala Asn Phe Arg Gln Val Phe Leu Ser Thr Leu 
    370                 375                 380                 


Ala Cys Leu Cys Pro Gly Trp Cys His Arg Arg Lys Lys Arg Pro Thr 
385                 390                 395                 400 


Phe Ser Arg Lys Pro Asn Ser Met Ser Ser Asn His Ala Phe Ser Thr 
                405                 410                 415     


Ser Ala Thr Arg Glu Thr Leu Tyr 
            420                 


<210>  13
<211>  424
<212>  PRT
<213>  Rattus norvegicus

<400>  13

Met His Leu Asn Ser Ser Val Pro Gln Gly Thr Pro Gly Glu Pro Asp 
1               5                   10                  15      


Ala Gln Pro Phe Ser Gly Pro Gln Ser Glu Met Glu Ala Thr Phe Leu 
            20                  25                  30          


Ala Leu Ser Leu Ser Asn Gly Ser Gly Asn Thr Ser Glu Ser Asp Thr 
        35                  40                  45              


Pro Gly Pro Asn Ser Asp Leu Asp Val Asn Thr Asp Ile Tyr Ser Lys 
    50                  55                  60                  


Val Leu Val Thr Ala Ile Tyr Leu Ala Leu Phe Val Val Gly Thr Val 
65                  70                  75                  80  


Gly Asn Ser Val Thr Ala Phe Thr Leu Ala Arg Lys Lys Ser Leu Gln 
                85                  90                  95      


Ser Leu Gln Ser Thr Val His Tyr His Leu Gly Ser Leu Ala Leu Ser 
            100                 105                 110         


Asn Leu Leu Ile Leu Leu Leu Ala Met Pro Val Glu Leu Tyr Asn Phe 
        115                 120                 125             


Ile Trp Val His His Pro Trp Ala Phe Gly Asp Ala Gly Cys Arg Gly 
    130                 135                 140                 


Tyr Tyr Phe Leu Arg Asp Ala Cys Thr Tyr Ala Thr Ala Leu Asn Val 
145                 150                 155                 160 


Ala Ser Leu Ser Val Glu Arg Tyr Leu Ala Ile Cys His Pro Phe Lys 
                165                 170                 175     


Ala Lys Thr Leu Met Ser Arg Ser Arg Thr Lys Lys Phe Ile Ser Ala 
            180                 185                 190         


Leu Trp Leu Ala Ser Ala Leu Leu Ala Ile Pro Met Leu Phe Thr Met 
        195                 200                 205             


Gly Leu Gln Asn Arg Ser Gly Asp Gly Thr His Pro Gly Gly Leu Val 
    210                 215                 220                 


Cys Thr Pro Ile Val Asp Thr Ala Thr Val Lys Val Ala Ile Gln Val 
225                 230                 235                 240 


Asn Thr Phe Met Ser Phe Leu Phe Pro Met Leu Val Ile Ser Ile Leu 
                245                 250                 255     


Asn Thr Val Ile Ser Asn Lys Leu Thr Val Met Gly His Gln Ala Ala 
            260                 265                 270         


Glu Gln Gly Arg Val Cys Thr Val Gly Thr His Asn Gly Leu Glu His 
        275                 280                 285             


Ser Thr Phe Asp Met Thr Ile Glu Pro Gly Arg Val Gln Ala Leu Arg 
    290                 295                 300                 


His Gly Val Leu Val Leu Arg Ala Val Val Ile Ala Phe Ala Val Cys 
305                 310                 315                 320 


Trp Leu Pro Tyr His Val Arg Arg Leu Met Phe Cys Tyr Ile Ser Asp 
                325                 330                 335     


Glu Gln Trp Thr Thr Phe Leu Phe Asp Phe Tyr His Tyr Phe Tyr Met 
            340                 345                 350         


Leu Thr Asn Thr Leu Leu Tyr Val Ser Ser Ala Ile Asn Pro Ile Leu 
        355                 360                 365             


Tyr Ile Leu Val Ser Ala Asn Phe Arg Gln Ala Phe Leu Ser Thr Leu 
    370                 375                 380                 


Ala Cys Leu Cys Pro Gly Trp Cys His Arg Arg Lys Lys Arg Pro Thr 
385                 390                 395                 400 


Phe Ser Arg Lys Pro Asn Ser Met Ser Ser Asn His Ala Phe Ser Thr 
                405                 410                 415     


Ser Ala Thr Arg Glu Thr Leu Tyr 
            420                 


<210>  14
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Asp Asn Val Leu Pro Val Asp Ser Asp Leu Ser Pro Asn Ile Ser 
1               5                   10                  15      


Thr Asn Thr Ser Glu Pro Asn Gln Phe Val Gln Pro Ala Trp Gln Ile 
            20                  25                  30          


Val Leu Trp Ala Ala Ala Tyr Thr Val Ile Val Val Thr Ser Val Val 
        35                  40                  45              


Gly Asn Val Val Val Met Trp Ile Ile Leu Ala His Lys Arg Met Arg 
    50                  55                  60                  


Thr Val Thr Asn Tyr Phe Leu Val Asn Leu Ala Phe Ala Glu Ala Ser 
65                  70                  75                  80  


Met Ala Ala Phe Asn Thr Val Val Asn Phe Thr Tyr Ala Val His Asn 
                85                  90                  95      


Glu Trp Tyr Tyr Gly Leu Phe Tyr Cys Lys Phe His Asn Phe Phe Pro 
            100                 105                 110         


Ile Ala Ala Val Phe Ala Ser Ile Tyr Ser Met Thr Ala Val Ala Phe 
        115                 120                 125             


Asp Arg Tyr Met Ala Ile Ile His Pro Leu Gln Pro Arg Leu Ser Ala 
    130                 135                 140                 


Thr Ala Thr Lys Val Val Ile Cys Val Ile Trp Val Leu Ala Leu Leu 
145                 150                 155                 160 


Leu Ala Phe Pro Gln Gly Tyr Tyr Ser Thr Thr Glu Thr Met Pro Ser 
                165                 170                 175     


Arg Val Val Cys Met Ile Glu Trp Pro Glu His Pro Asn Lys Ile Tyr 
            180                 185                 190         


Glu Lys Val Tyr His Ile Cys Val Thr Val Leu Ile Tyr Phe Leu Pro 
        195                 200                 205             


Leu Leu Val Ile Gly Tyr Ala Tyr Thr Val Val Gly Ile Thr Leu Trp 
    210                 215                 220                 


Ala Ser Glu Ile Pro Gly Asp Ser Ser Asp Arg Tyr His Glu Gln Val 
225                 230                 235                 240 


Ser Ala Lys Arg Lys Val Val Lys Met Met Ile Val Val Val Cys Thr 
                245                 250                 255     


Phe Ala Ile Cys Trp Leu Pro Phe His Ile Phe Phe Leu Leu Pro Tyr 
            260                 265                 270         


Ile Asn Pro Asp Leu Tyr Leu Lys Lys Phe Ile Gln Gln Val Tyr Leu 
        275                 280                 285             


Ala Ile Met Trp Leu Ala Met Ser Ser Thr Met Tyr Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Cys Cys Leu Asn Asp Arg Phe Arg Leu Gly Phe Lys His Ala Phe 
305                 310                 315                 320 


Arg Cys Cys Pro Phe Ile Ser Ala Gly Asp Tyr Glu Gly Leu Glu Met 
                325                 330                 335     


Lys Ser Thr Arg Tyr Leu Gln Thr Gln Gly Ser Val Tyr Lys Val Ser 
            340                 345                 350         


Arg Leu Glu Thr Thr Ile Ser Thr Val Val Gly Ala His Glu Glu Glu 
        355                 360                 365             


Pro Glu Asp Gly Pro Lys Ala Thr Pro Ser Ser Leu Asp Leu Thr Ser 
    370                 375                 380                 


Asn Cys Ser Ser Arg Ser Asp Ser Lys Thr Met Thr Glu Ser Phe Ser 
385                 390                 395                 400 


Phe Ser Ser Asn Val Leu Ser 
                405         


<210>  15
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Asp Asn Val Leu Pro Val Asp Ser Asp Leu Ser Pro Asn Ile Ser 
1               5                   10                  15      


Thr Asn Thr Ser Glu Pro Asn Gln Phe Val Gln Pro Ala Trp Gln Ile 
            20                  25                  30          


Val Leu Trp Ala Ala Ala Tyr Thr Val Ile Val Val Thr Ser Val Val 
        35                  40                  45              


Gly Asn Val Val Val Met Trp Ile Ile Leu Ala His Lys Arg Met Arg 
    50                  55                  60                  


Thr Val Thr Asn Tyr Phe Leu Val Asn Leu Ala Phe Ala Glu Ala Ser 
65                  70                  75                  80  


Met Ala Ala Phe Asn Thr Val Val Asn Phe Thr Tyr Ala Val His Asn 
                85                  90                  95      


Glu Trp Tyr Tyr Gly Leu Phe Tyr Cys Lys Phe His Asn Phe Phe Pro 
            100                 105                 110         


Ile Ala Ala Val Phe Ala Ser Ile Tyr Ser Met Thr Ala Val Ala Phe 
        115                 120                 125             


Asp Arg Tyr Met Ala Ile Ile His Pro Leu Gln Pro Arg Leu Ser Ala 
    130                 135                 140                 


Thr Ala Thr Lys Val Val Ile Cys Val Ile Trp Val Leu Ala Leu Leu 
145                 150                 155                 160 


Leu Ala Phe Pro Gln Gly Tyr Tyr Ser Thr Thr Glu Thr Met Pro Ser 
                165                 170                 175     


Arg Val Val Cys Met Ile Glu Trp Pro Glu His Pro Asn Lys Ile Tyr 
            180                 185                 190         


Glu Lys Val Tyr His Ile Cys Val Thr Val Leu Ile Tyr Phe Leu Pro 
        195                 200                 205             


Leu Leu Val Ile Gly Tyr Ala Tyr Thr Val Val Gly Ile Thr Leu Trp 
    210                 215                 220                 


Ala Ser Glu Ile Pro Gly Asp Ser Ser Asp Arg Tyr His Glu Gln Val 
225                 230                 235                 240 


Ser Ala Lys Arg Lys Val Val Lys Met Met Ile Val Val Val Cys Thr 
                245                 250                 255     


Phe Ala Ile Cys Trp Leu Pro Phe His Ile Phe Phe Leu Leu Pro Tyr 
            260                 265                 270         


Ile Asn Pro Asp Leu Tyr Leu Lys Lys Phe Ile Gln Gln Val Tyr Leu 
        275                 280                 285             


Ala Ile Met Trp Leu Ala Met Ser Ser Thr Met Tyr Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Cys Cys Leu Asn Asp Arg Phe Arg Leu Gly Phe Lys His Ala Phe 
305                 310                 315                 320 


Arg Cys Cys Pro Phe Ile Ser Ala Gly Asp Tyr Glu Gly Leu Lys Met 
                325                 330                 335     


Lys Ser Thr Arg Tyr Leu Gln Thr Gln Gly Ser Val Tyr Lys Val Ser 
            340                 345                 350         


Arg Leu Glu Thr Thr Ile Ser Thr Val Val Gly Ala His Glu Glu Glu 
        355                 360                 365             


Pro Glu Asp Gly Pro Lys Ala Thr Pro Ser Ser Leu Asp Leu Thr Ser 
    370                 375                 380                 


Asn Cys Ser Ser Arg Ser Asp Ser Lys Thr Met Thr Glu Ser Phe Ser 
385                 390                 395                 400 


Phe Ser Ser Asn Val Leu Ser 
                405         


<210>  16
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Asp Asn Val Leu Pro Val Asp Ser Asp Leu Ser Pro Asn Ile Ser 
1               5                   10                  15      


Thr Asn Thr Ser Glu Pro Asn Gln Phe Val Gln Pro Ala Trp Gln Ile 
            20                  25                  30          


Val Leu Trp Ala Ala Ala Tyr Thr Val Ile Val Val Thr Ser Val Val 
        35                  40                  45              


Gly Asn Val Val Val Met Trp Ile Ile Leu Ala His Lys Arg Met Arg 
    50                  55                  60                  


Thr Val Thr Asn Tyr Phe Leu Val Asn Leu Ala Phe Ala Glu Ala Ser 
65                  70                  75                  80  


Met Ala Ala Phe Asn Thr Val Val Asn Phe Thr Tyr Ala Val His Asn 
                85                  90                  95      


Glu Trp Tyr Tyr Gly Leu Phe Tyr Cys Lys Phe His Asn Phe Phe Pro 
            100                 105                 110         


Ile Ala Ala Val Phe Ala Ser Ile Tyr Ser Met Thr Ala Val Ala Phe 
        115                 120                 125             


Asp Arg Tyr Met Ala Ile Ile His Pro Leu Gln Pro Arg Leu Ser Ala 
    130                 135                 140                 


Thr Ala Thr Lys Val Val Ile Cys Val Ile Trp Val Leu Ala Leu Leu 
145                 150                 155                 160 


Leu Ala Phe Pro Gln Gly Tyr Tyr Ser Thr Thr Glu Thr Met Pro Ser 
                165                 170                 175     


Arg Val Val Cys Met Ile Glu Trp Pro Glu His Pro Asn Lys Ile Tyr 
            180                 185                 190         


Glu Lys Val Tyr His Ile Cys Val Thr Val Leu Ile Tyr Phe Leu Pro 
        195                 200                 205             


Leu Leu Val Ile Gly Tyr Ala Tyr Ser Val Val Gly Ile Thr Leu Trp 
    210                 215                 220                 


Ala Ser Glu Ile Pro Gly Asp Ser Ser Asp Arg Tyr His Glu Gln Val 
225                 230                 235                 240 


Ser Ala Lys Arg Lys Val Val Lys Met Met Ile Val Val Val Cys Thr 
                245                 250                 255     


Phe Ala Ile Cys Trp Leu Pro Phe His Ile Phe Phe Leu Leu Pro Tyr 
            260                 265                 270         


Ile Asn Pro Asp Leu Tyr Leu Lys Lys Phe Ile Gln Gln Ala Tyr Leu 
        275                 280                 285             


Ala Ile Met Trp Leu Ala Met Ser Ser Thr Met Tyr Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Cys Cys Leu Asn Asp Arg Phe Arg Leu Gly Phe Lys His Ala Phe 
305                 310                 315                 320 


Arg Cys Cys Pro Phe Ile Ser Ala Gly Asp Tyr Glu Gly Leu Glu Met 
                325                 330                 335     


Lys Ser Thr Arg Tyr Leu Gln Thr Gln Gly Ser Val Tyr Lys Val Ser 
            340                 345                 350         


Arg Leu Glu Thr Thr Ile Ser Thr Val Val Gly Ala His Glu Glu Glu 
        355                 360                 365             


Pro Glu Asp Gly Pro Lys Ala Thr Pro Ser Ser Leu Asp Leu Thr Ser 
    370                 375                 380                 


Asn Cys Ser Ser Arg Ser Asp Ser Lys Thr Met Thr Glu Ser Phe Ser 
385                 390                 395                 400 


Phe Ser Ser Asn Val Leu Ser 
                405         


<210>  17
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Asp Asn Val Leu Pro Val Asp Ser Asp Leu Ser Pro Asn Ile Ser 
1               5                   10                  15      


Thr Asn Thr Ser Glu Pro Asn Gln Phe Val Gln Pro Ala Trp Gln Ile 
            20                  25                  30          


Val Leu Trp Ala Ala Ala Tyr Thr Val Ile Val Val Thr Ser Val Val 
        35                  40                  45              


Gly Asn Val Val Val Met Trp Ile Ile Leu Ala His Lys Arg Met Arg 
    50                  55                  60                  


Thr Val Thr Asn Tyr Phe Leu Val Asn Leu Ala Phe Ala Glu Ala Ser 
65                  70                  75                  80  


Met Ala Ala Phe Asn Thr Val Val Asn Phe Thr Tyr Ala Val His Asn 
                85                  90                  95      


Glu Trp Tyr Tyr Gly Leu Phe Tyr Cys Lys Phe His Asn Phe Phe Pro 
            100                 105                 110         


Ile Ala Ala Val Phe Ala Ser Ile Tyr Ser Met Thr Ala Val Ala Phe 
        115                 120                 125             


Asp Arg Tyr Met Ala Ile Ile His Pro Leu Gln Pro Arg Leu Ser Ala 
    130                 135                 140                 


Thr Ala Thr Lys Val Val Ile Cys Val Ile Trp Val Leu Ala Leu Leu 
145                 150                 155                 160 


Leu Ala Phe Pro Gln Gly Tyr Tyr Ser Thr Thr Glu Thr Met Pro Ser 
                165                 170                 175     


Arg Val Val Cys Met Ile Glu Trp Pro Glu His Pro Asn Lys Ile Tyr 
            180                 185                 190         


Glu Lys Val Tyr His Ile Cys Val Thr Val Leu Ile Tyr Phe Leu Pro 
        195                 200                 205             


Leu Leu Val Ile Gly Tyr Ala Tyr Thr Val Val Gly Ile Thr Leu Trp 
    210                 215                 220                 


Ala Ser Glu Ile Pro Gly Asp Ser Ser Asp Arg Tyr His Glu Gln Val 
225                 230                 235                 240 


Ser Ala Lys Arg Lys Val Val Lys Met Met Ile Val Val Val Cys Thr 
                245                 250                 255     


Phe Ala Ile Cys Trp Leu Pro Phe His Ile Phe Phe Leu Leu Pro Tyr 
            260                 265                 270         


Ile Tyr Pro Asp Leu Tyr Leu Lys Lys Phe Ile Gln Gln Val Tyr Leu 
        275                 280                 285             


Ala Ile Met Trp Leu Ala Met Ser Ser Thr Met Tyr Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Cys Cys Leu Asn Asp Arg Phe Arg Leu Gly Phe Lys His Ala Phe 
305                 310                 315                 320 


Arg Cys Cys Pro Phe Ile Ser Ala Gly Asp Tyr Glu Gly Leu Glu Met 
                325                 330                 335     


Lys Ser Thr Arg Tyr Leu Gln Thr Gln Gly Ser Val Tyr Lys Val Ser 
            340                 345                 350         


Arg Leu Glu Thr Thr Ile Ser Thr Val Val Gly Ala His Glu Glu Glu 
        355                 360                 365             


Pro Glu Asp Gly Pro Lys Ala Thr Pro Ser Ser Leu Asp Leu Thr Ser 
    370                 375                 380                 


Asn Cys Ser Ser Arg Ser Asp Ser Lys Thr Met Thr Glu Ser Phe Ser 
385                 390                 395                 400 


Phe Ser Ser Asn Val Leu Ser 
                405         


<210>  18
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Asp Asn Val Leu Pro Val Asp Ser Asp Leu Ser Pro Asn Ile Ser 
1               5                   10                  15      


Thr Asn Thr Ser Glu Pro Asn Gln Phe Val Gln Pro Ala Trp Gln Ile 
            20                  25                  30          


Val Leu Trp Ala Ala Ala Tyr Thr Val Ile Val Val Thr Ser Val Val 
        35                  40                  45              


Gly Asn Val Val Val Met Trp Ile Ile Leu Ala His Lys Arg Met Arg 
    50                  55                  60                  


Thr Val Thr Asn Tyr Phe Leu Val Asn Leu Ala Phe Ala Glu Ala Ser 
65                  70                  75                  80  


Met Ala Ala Phe Asn Thr Val Val Asn Phe Thr Tyr Ala Val His Asn 
                85                  90                  95      


Glu Trp Tyr Tyr Gly Leu Phe Tyr Cys Lys Phe His Asn Phe Phe Pro 
            100                 105                 110         


Ile Ala Ala Val Phe Ala Ser Ile Tyr Ser Met Thr Ala Val Ala Phe 
        115                 120                 125             


Asp Arg Tyr Met Ala Ile Ile His Pro Leu Gln Pro Arg Leu Ser Ala 
    130                 135                 140                 


Thr Ala Thr Lys Val Val Ile Cys Val Ile Trp Val Leu Ala Leu Leu 
145                 150                 155                 160 


Leu Ala Phe Pro Gln Gly Tyr Tyr Ser Thr Thr Glu Thr Met Pro Ser 
                165                 170                 175     


Arg Val Val Cys Met Ile Glu Trp Pro Glu His Pro Asn Lys Ile Tyr 
            180                 185                 190         


Glu Lys Val Tyr His Ile Cys Val Thr Val Leu Ile Tyr Phe Leu Pro 
        195                 200                 205             


Leu Leu Val Ile Gly Tyr Ala Tyr Thr Val Val Gly Ile Thr Leu Trp 
    210                 215                 220                 


Ala Ser Glu Ile Pro Gly Asp Ser Ser Asp Arg Tyr His Glu Gln Val 
225                 230                 235                 240 


Ser Ala Lys Arg Lys Val Val Lys Met Met Ile Val Val Val Cys Thr 
                245                 250                 255     


Phe Ala Ile Cys Trp Leu Pro Phe His Ile Phe Phe Leu Leu Pro Tyr 
            260                 265                 270         


Ile Asn Pro Asp Leu Tyr Leu Lys Lys Phe Ile Gln Gln Val Tyr Leu 
        275                 280                 285             


Ala Ile Met Trp Leu Ala Met Ser Ser Thr Met Tyr Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Cys Cys Leu Asn Asp Arg Phe Arg Leu Gly Phe Lys His Ala Phe 
305                 310                 315                 320 


Arg Cys Cys Pro Phe Ile Ser Ala Gly Asp Tyr Glu Gly Leu Glu Met 
                325                 330                 335     


Lys Ser Thr Arg Tyr Leu Gln Thr Gln Gly Ser Val Tyr Lys Val Ser 
            340                 345                 350         


Arg Leu Glu Thr Thr Ile Ser Thr Val Val Gly Ala His Glu Glu Glu 
        355                 360                 365             


Pro Glu Asp Gly Pro Lys Ala Thr Pro Ser Ser Leu Asp Leu Thr Ser 
    370                 375                 380                 


Asn Cys Ser Ser Arg Ser Asp Ser Lys Thr Met Thr Glu Ser Phe Ser 
385                 390                 395                 400 


Phe Ser Ser Asn Val Leu Ser 
                405         


<210>  19
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Asp Asn Val Leu Pro Val Asp Ser Asp Leu Ser Pro Asn Ile Ser 
1               5                   10                  15      


Thr Asn Thr Ser Glu Pro Asn Gln Phe Val Gln Pro Ala Trp Gln Ile 
            20                  25                  30          


Val Leu Trp Ala Ala Ala Tyr Thr Val Ile Val Val Thr Ser Val Val 
        35                  40                  45              


Gly Asn Val Val Val Met Trp Ile Ile Leu Ala His Lys Arg Met Arg 
    50                  55                  60                  


Thr Val Thr Asn Tyr Phe Leu Val Asn Leu Ala Phe Ala Glu Ala Ser 
65                  70                  75                  80  


Met Ala Ala Phe Asn Thr Val Val Asn Phe Thr Tyr Ala Val His Asn 
                85                  90                  95      


Glu Trp Tyr Tyr Gly Leu Phe Tyr Cys Lys Phe His Asn Phe Phe Pro 
            100                 105                 110         


Ile Ala Ala Ile Phe Ala Ser Ile Tyr Ser Met Thr Ala Val Ala Phe 
        115                 120                 125             


Asp Arg Tyr Met Ala Ile Ile His Pro Leu Gln Pro Arg Leu Ser Ala 
    130                 135                 140                 


Thr Ala Thr Lys Val Val Ile Cys Val Ile Trp Val Leu Ala Leu Leu 
145                 150                 155                 160 


Leu Ala Phe Pro Gln Gly Tyr Tyr Ser Thr Thr Glu Thr Met Pro Ser 
                165                 170                 175     


Arg Val Val Cys Lys Ile Glu Trp Pro Glu His Pro Asn Lys Ile Tyr 
            180                 185                 190         


Glu Lys Val Tyr His Ile Cys Val Thr Val Leu Ile Tyr Phe Leu Pro 
        195                 200                 205             


Leu Leu Val Ile Gly Tyr Ala Tyr Thr Val Val Gly Ile Thr Leu Arg 
    210                 215                 220                 


Ala Ser Glu Ile Pro Gly Asp Ser Ser Asp Arg Tyr His Glu Gln Val 
225                 230                 235                 240 


Ser Ala Lys Arg Lys Val Val Lys Met Met Ile Val Val Val Cys Thr 
                245                 250                 255     


Phe Ala Ile Cys Trp Leu Pro Phe His Ile Phe Phe Leu Leu Pro Tyr 
            260                 265                 270         


Ile Asn Pro Asp Leu Tyr Leu Lys Lys Phe Ile Gln Gln Val Tyr Leu 
        275                 280                 285             


Ala Ile Met Trp Leu Ala Met Ser Ser Thr Met Tyr Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Cys Cys Leu Asn Asp Arg Phe Arg Leu Gly Phe Lys His Ala Phe 
305                 310                 315                 320 


Arg Cys Cys Pro Phe Ile Ser Ala Gly Asp Tyr Glu Gly Leu Glu Met 
                325                 330                 335     


Lys Ser Thr Arg Tyr Leu Gln Thr Gln Gly Ser Val Tyr Lys Val Ser 
            340                 345                 350         


Arg Leu Glu Thr Thr Ile Ser Thr Val Val Gly Ala His Glu Glu Glu 
        355                 360                 365             


Pro Glu Asp Gly Pro Lys Ala Thr Pro Ser Ser Leu Asp Leu Thr Ser 
    370                 375                 380                 


Asn Cys Ser Ser Arg Ser Asp Ser Lys Thr Met Thr Glu Ser Phe Ser 
385                 390                 395                 400 


Phe Ser Ser Asn Val Leu Ser 
                405         


<210>  20
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Asp Asn Val Leu Pro Val Asp Ser Asp Leu Ser Pro Asn Ile Ser 
1               5                   10                  15      


Thr Asn Thr Ser Glu Pro Asn Gln Phe Val Gln Pro Ala Trp Gln Ile 
            20                  25                  30          


Val Leu Trp Ala Ala Ala Tyr Thr Val Ile Val Val Thr Ser Val Val 
        35                  40                  45              


Gly Asn Val Val Val Met Trp Ile Ile Leu Ala His Lys Arg Met Arg 
    50                  55                  60                  


Thr Val Thr Asn Tyr Phe Leu Val Asn Leu Ala Phe Ala Glu Ala Ser 
65                  70                  75                  80  


Met Ala Ala Phe Asn Thr Val Val Asn Phe Thr Tyr Ala Val His Asn 
                85                  90                  95      


Glu Trp Tyr Tyr Gly Leu Phe Tyr Cys Lys Phe His Asn Phe Phe Pro 
            100                 105                 110         


Ile Ala Ala Ile Phe Ala Ser Ile Tyr Ser Met Thr Ala Val Ala Phe 
        115                 120                 125             


Asp Arg Tyr Met Ala Ile Ile His Pro Leu Gln Pro Arg Leu Ser Ala 
    130                 135                 140                 


Thr Ala Thr Lys Val Val Ile Cys Val Ile Trp Val Leu Ala Leu Leu 
145                 150                 155                 160 


Leu Ala Phe Pro Gln Gly Tyr Tyr Ser Thr Thr Glu Thr Met Pro Ser 
                165                 170                 175     


Arg Val Val Cys Lys Ile Glu Trp Pro Glu His Pro Asn Lys Ile Tyr 
            180                 185                 190         


Glu Lys Val Tyr His Ile Cys Val Thr Val Leu Ile Tyr Phe Leu Pro 
        195                 200                 205             


Leu Leu Val Ile Gly Tyr Ala Tyr Thr Val Val Gly Ile Thr Leu Arg 
    210                 215                 220                 


Ala Ser Glu Ile Pro Gly Asp Ser Ser Asp Arg Tyr His Glu Gln Val 
225                 230                 235                 240 


Ser Ala Lys Arg Lys Val Val Lys Met Met Ile Val Val Val Cys Thr 
                245                 250                 255     


Phe Ala Ile Cys Trp Leu Pro Phe His Ile Phe Phe Leu Leu Pro Tyr 
            260                 265                 270         


Ile Asn Pro Asp Leu Tyr Leu Lys Lys Phe Ile Gln Gln Val Tyr Leu 
        275                 280                 285             


Ala Ile Met Trp Leu Ala Met Ser Ser Thr Met Tyr Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Cys Cys Leu Asn Asp Arg Phe Arg Leu Gly Phe Lys His Ala Phe 
305                 310                 315                 320 


Arg Trp Cys Pro Phe Ile Ser Ala Gly Asp Tyr Glu Gly Leu Lys Met 
                325                 330                 335     


Lys Ser Thr Arg Tyr Leu Gln Thr Gln Gly Ser Val Tyr Lys Val Ser 
            340                 345                 350         


Arg Leu Glu Thr Thr Ile Ser Thr Val Val Gly Ala His Glu Glu Glu 
        355                 360                 365             


Pro Glu Asp Gly Pro Lys Ala Thr Pro Ser Ser Leu Asp Leu Thr Ser 
    370                 375                 380                 


Asn Cys Ser Ser Arg Ser Asp Ser Lys Thr Met Thr Glu Ser Phe Ser 
385                 390                 395                 400 


Phe Ser Ser Asn Val Leu Ser 
                405         


<210>  21
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Asp Asn Val Leu Pro Val Asp Ser Asp Leu Ser Pro Asn Ile Ser 
1               5                   10                  15      


Thr Asn Thr Ser Glu Pro Asn Gln Phe Val Gln Pro Ala Trp Gln Ile 
            20                  25                  30          


Val Leu Trp Ala Ala Ala Tyr Ala Val Ile Val Val Thr Ser Val Val 
        35                  40                  45              


Gly Asn Val Val Val Met Trp Ile Ile Leu Ala His Lys Arg Met Arg 
    50                  55                  60                  


Thr Val Thr Asn Tyr Phe Leu Val Asn Leu Ala Phe Ala Glu Ala Ser 
65                  70                  75                  80  


Met Ala Ala Phe Asn Thr Val Val Asn Phe Thr Tyr Ala Val His Asn 
                85                  90                  95      


Glu Trp Tyr Tyr Gly Leu Phe Tyr Cys Lys Phe His Asn Phe Phe Pro 
            100                 105                 110         


Ile Ala Ala Ile Phe Ala Ser Ile Tyr Ser Met Thr Ala Val Ala Phe 
        115                 120                 125             


Asp Arg Tyr Met Ala Ile Ile His Pro Leu Gln Pro Arg Leu Ser Ala 
    130                 135                 140                 


Thr Ala Thr Lys Val Val Ile Cys Val Ile Trp Val Leu Ala Leu Leu 
145                 150                 155                 160 


Leu Ala Phe Pro Gln Gly Tyr Tyr Ser Thr Thr Glu Thr Met Pro Ser 
                165                 170                 175     


Arg Val Val Cys Lys Ile Glu Trp Pro Glu His Pro Asn Lys Ile Tyr 
            180                 185                 190         


Glu Lys Val Tyr His Ile Cys Val Thr Val Leu Ile Tyr Phe Leu Pro 
        195                 200                 205             


Leu Leu Val Ile Gly Tyr Ala Tyr Thr Val Val Gly Ile Thr Leu Arg 
    210                 215                 220                 


Ala Ser Glu Ile Pro Gly Asp Ser Ser Asp Arg Tyr His Glu Gln Val 
225                 230                 235                 240 


Ser Ala Lys Arg Lys Val Val Lys Met Met Ile Val Val Val Cys Thr 
                245                 250                 255     


Phe Ala Ile Cys Trp Leu Pro Phe His Ile Phe Phe Leu Leu Pro Tyr 
            260                 265                 270         


Ile Asn Pro Asp Leu Tyr Leu Lys Lys Phe Ile Gln Gln Val Tyr Leu 
        275                 280                 285             


Ala Ile Met Trp Leu Ala Met Ser Ser Thr Met Tyr Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Cys Cys Leu Asn Asp Arg Phe Arg Leu Gly Phe Lys His Ala Phe 
305                 310                 315                 320 


Arg Trp Cys Pro Phe Ile Ser Ala Gly Asp Tyr Glu Gly Leu Lys Met 
                325                 330                 335     


Lys Ser Thr Arg Tyr Leu Gln Thr Gln Gly Ser Val Tyr Lys Val Ser 
            340                 345                 350         


Arg Leu Glu Thr Thr Ile Ser Thr Val Val Gly Ala His Glu Glu Glu 
        355                 360                 365             


Pro Glu Asp Gly Pro Lys Ala Thr Pro Ser Ser Leu Asp Leu Thr Ser 
    370                 375                 380                 


Asn Cys Ser Ser Arg Ser Asp Ser Lys Thr Met Thr Glu Ser Phe Ser 
385                 390                 395                 400 


Phe Ser Ser Asn Val Leu Ser 
                405         


<210>  22
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Asp Asn Val Leu Pro Val Asp Ser Asp Leu Ser Pro Asn Ile Ser 
1               5                   10                  15      


Thr Asn Thr Ser Glu Pro Asn Gln Phe Val Gln Pro Ala Trp Gln Ile 
            20                  25                  30          


Val Leu Trp Ala Ala Ala Tyr Thr Val Ile Val Val Thr Ser Val Val 
        35                  40                  45              


Gly Asn Val Val Val Met Trp Ile Ile Leu Ala His Lys Arg Met Arg 
    50                  55                  60                  


Thr Val Thr Asn Tyr Phe Leu Val Asn Leu Ala Phe Ala Glu Ala Ser 
65                  70                  75                  80  


Met Ala Ala Phe Asn Thr Val Val Asn Phe Thr Tyr Ala Val His Asn 
                85                  90                  95      


Glu Trp Tyr Tyr Gly Leu Phe Tyr Cys Lys Phe His Asn Phe Phe Pro 
            100                 105                 110         


Ile Ala Ala Ile Phe Ala Ser Ile Tyr Ser Met Thr Ala Val Ala Phe 
        115                 120                 125             


Asp Arg Tyr Met Ala Ile Ile His Pro Leu Gln Pro Arg Leu Ser Ala 
    130                 135                 140                 


Thr Ala Thr Lys Val Val Ile Cys Val Ile Trp Val Leu Ala Leu Leu 
145                 150                 155                 160 


Leu Ala Phe Pro Gln Gly Tyr Tyr Ser Thr Thr Glu Thr Met Pro Ser 
                165                 170                 175     


Arg Val Val Cys Lys Ile Glu Trp Pro Glu His Pro Asn Lys Ile Tyr 
            180                 185                 190         


Glu Lys Val Tyr His Ile Cys Val Thr Val Leu Ile Tyr Phe Leu Pro 
        195                 200                 205             


Leu Leu Val Ile Gly Tyr Ala Tyr Thr Val Val Gly Ile Thr Leu Trp 
    210                 215                 220                 


Ala Ser Glu Ile Pro Gly Asp Ser Ser Asp Arg Tyr His Glu Gln Val 
225                 230                 235                 240 


Ser Ala Lys Arg Lys Val Val Lys Met Met Ile Val Val Val Cys Thr 
                245                 250                 255     


Phe Ala Ile Cys Trp Leu Pro Phe His Ile Phe Phe Leu Leu Pro Tyr 
            260                 265                 270         


Ile Asn Pro Asp Leu Tyr Leu Lys Lys Phe Ile Gln Gln Val Tyr Leu 
        275                 280                 285             


Ala Ile Met Trp Leu Ala Met Ser Ser Thr Met Tyr Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Cys Cys Leu Asn Asp Arg Phe Arg Leu Gly Phe Lys His Ala Phe 
305                 310                 315                 320 


Arg Trp Cys Pro Phe Ile Ser Ala Gly Asp Tyr Glu Gly Leu Lys Met 
                325                 330                 335     


Lys Ser Thr Arg Tyr Leu Gln Thr Gln Gly Ser Val Tyr Lys Val Ser 
            340                 345                 350         


Arg Leu Glu Thr Thr Ile Ser Thr Val Val Gly Ala His Glu Glu Glu 
        355                 360                 365             


Pro Glu Asp Gly Pro Lys Ala Thr Pro Ser Ser Leu Asp Leu Thr Ser 
    370                 375                 380                 


Asn Cys Ser Ser Arg Ser Asp Ser Lys Thr Met Thr Glu Ser Phe Ser 
385                 390                 395                 400 


Phe Ser Ser Asn Val Leu Ser 
                405         


<210>  23
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Asp Asn Val Leu Pro Val Asp Ser Asp Leu Ser Pro Asn Ile Ser 
1               5                   10                  15      


Thr Asn Thr Ser Glu Pro Asn Gln Phe Val Gln Pro Ala Trp Gln Ile 
            20                  25                  30          


Val Leu Trp Ala Ala Ala Tyr Ala Val Ile Val Val Thr Ser Val Val 
        35                  40                  45              


Gly Asn Val Val Val Met Trp Ile Ile Leu Ala His Lys Ser Met Arg 
    50                  55                  60                  


Thr Val Thr Asn Tyr Phe Leu Val Asn Leu Ala Phe Ala Glu Ala Ser 
65                  70                  75                  80  


Met Ala Ala Phe Asn Thr Val Val Asn Phe Thr Tyr Ala Val His Asn 
                85                  90                  95      


Glu Trp Tyr Tyr Gly Leu Phe Tyr Cys Lys Phe His Asn Phe Phe Pro 
            100                 105                 110         


Ile Ala Ala Val Phe Ala Ser Ile Tyr Ser Met Thr Ala Val Ala Phe 
        115                 120                 125             


Asp Arg Tyr Met Ala Ile Ile His Pro Leu Gln Pro Arg Leu Ser Ala 
    130                 135                 140                 


Thr Ala Thr Lys Val Val Ile Cys Val Ile Trp Val Leu Ala Leu Leu 
145                 150                 155                 160 


Leu Ala Phe Pro Gln Gly Tyr Tyr Ser Thr Thr Glu Thr Met Pro Ser 
                165                 170                 175     


Arg Val Val Cys Met Ile Glu Trp Pro Glu His Pro Asn Lys Ile Tyr 
            180                 185                 190         


Glu Lys Val Tyr His Ile Cys Val Thr Val Leu Ile Tyr Phe Leu Pro 
        195                 200                 205             


Leu Leu Val Ile Gly Tyr Ala Tyr Thr Val Val Gly Ile Thr Leu Trp 
    210                 215                 220                 


Ala Ser Glu Ile Pro Gly Asp Ser Ser Asp Arg Tyr His Glu Gln Val 
225                 230                 235                 240 


Ser Ala Lys Arg Lys Val Val Lys Met Met Ile Val Val Val Cys Thr 
                245                 250                 255     


Phe Ala Ile Cys Trp Leu Pro Tyr His Ile Phe Phe Leu Leu Pro Tyr 
            260                 265                 270         


Ile Asn Pro Asp Leu Tyr Leu Lys Lys Phe Ile Gln Gln Val Tyr Leu 
        275                 280                 285             


Ala Ile Met Trp Leu Ala Met Ser Ser Thr Thr Tyr Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Cys Cys Leu Asn Asp Arg Phe Arg Leu Gly Phe Lys His Ala Phe 
305                 310                 315                 320 


Arg Cys Cys Pro Phe Ile Ser Ala Gly Asp Tyr Glu Gly Leu Glu Met 
                325                 330                 335     


Lys Ser Thr Arg Tyr Leu Gln Thr Gln Gly Ser Val Tyr Lys Val Ser 
            340                 345                 350         


Arg Leu Glu Thr Thr Ile Ser Thr Val Val Gly Ala His Glu Glu Glu 
        355                 360                 365             


Pro Glu Asp Gly Pro Lys Ala Thr Pro Ser Ser Leu Asp Leu Thr Ser 
    370                 375                 380                 


Asn Cys Ser Ser Arg Ser Asp Ser Lys Thr Met Thr Glu Ser Phe Ser 
385                 390                 395                 400 


Phe Ser Ser Asn Val Leu Ser 
                405         


<210>  24
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Asp Asn Val Leu Pro Val Asp Ser Asp Leu Ser Pro Asn Ile Ser 
1               5                   10                  15      


Thr Asn Thr Ser Glu Pro Asn Gln Phe Val Gln Pro Ala Trp Gln Ile 
            20                  25                  30          


Val Leu Trp Ala Ala Ala Tyr Thr Val Ile Val Val Thr Ser Val Val 
        35                  40                  45              


Gly Asn Val Val Val Met Trp Ile Ile Leu Ala His Lys Arg Met Arg 
    50                  55                  60                  


Thr Val Thr Asn Tyr Phe Leu Val Asn Leu Ala Phe Ala Glu Ala Ser 
65                  70                  75                  80  


Met Ala Ala Phe Asn Thr Val Val Asn Phe Thr Tyr Ala Val Arg Asn 
                85                  90                  95      


Glu Trp Tyr Tyr Gly Leu Phe Tyr Cys Lys Phe His Asn Phe Phe Pro 
            100                 105                 110         


Ile Ala Ala Val Phe Ala Ser Ile Tyr Ser Met Thr Ala Val Ala Phe 
        115                 120                 125             


Asp Arg Tyr Met Ala Ile Ile His Pro His Gln Pro Arg Leu Ser Ala 
    130                 135                 140                 


Thr Ala Thr Lys Val Val Ile Cys Val Ile Trp Val Leu Ala Leu Leu 
145                 150                 155                 160 


Leu Ala Phe Pro Gln Gly Tyr Tyr Ser Thr Thr Glu Thr Met Pro Ser 
                165                 170                 175     


Arg Val Val Cys Lys Ile Glu Trp Pro Glu His Pro Asn Lys Ile Tyr 
            180                 185                 190         


Glu Lys Val Tyr His Ile Cys Val Thr Val Leu Ile Tyr Phe Leu Pro 
        195                 200                 205             


Leu Leu Val Ile Gly Tyr Ala Tyr Thr Val Val Gly Ile Thr Leu Arg 
    210                 215                 220                 


Ala Ser Glu Ile Pro Gly Asp Ser Ser Asp Arg Tyr His Glu Gln Val 
225                 230                 235                 240 


Ser Ala Lys Arg Lys Val Val Lys Met Met Ile Val Val Val Cys Thr 
                245                 250                 255     


Phe Ala Ile Cys Trp Leu Pro Phe His Ile Phe Phe Leu Leu Pro Tyr 
            260                 265                 270         


Ile Asn Pro Asp Leu Phe Leu Lys Lys Phe Ile Gln Gln Val Tyr Leu 
        275                 280                 285             


Ala Ile Met Trp Leu Ala Met Ser Ser Thr Met Tyr Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Cys Cys Leu Asn Asp Arg Phe Arg Leu Gly Phe Lys His Ala Phe 
305                 310                 315                 320 


Arg Trp Cys Pro Phe Ile Ser Ala Gly Asp Tyr Glu Gly Leu Lys Met 
                325                 330                 335     


Lys Ser Thr Arg Tyr Leu Gln Thr Gln Gly Ser Val Tyr Lys Val Ser 
            340                 345                 350         


Arg Leu Glu Thr Thr Ile Ser Thr Val Val Gly Ala His Glu Glu Glu 
        355                 360                 365             


Pro Glu Asp Gly Pro Lys Ala Thr Pro Ser Ser Leu Asp Leu Thr Ser 
    370                 375                 380                 


Asn Cys Ser Ser Arg Ser Asp Ser Lys Thr Met Thr Glu Ser Phe Ser 
385                 390                 395                 400 


Phe Ser Ser Asn Val Leu Ser 
                405         


<210>  25
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Asp Asn Val Leu Pro Val Asp Ser Asp Leu Ser Pro Asn Ile Ser 
1               5                   10                  15      


Thr Asn Thr Ser Glu Pro Asn Gln Phe Val Gln Pro Ala Trp Gln Ile 
            20                  25                  30          


Val Leu Trp Ala Ala Ala Tyr Thr Val Ile Val Val Thr Ser Val Val 
        35                  40                  45              


Gly Asn Val Val Val Met Trp Ile Ile Leu Ala His Lys Arg Met Arg 
    50                  55                  60                  


Thr Val Thr Asn Tyr Phe Leu Val Asn Leu Ala Phe Ala Glu Ala Ser 
65                  70                  75                  80  


Met Ala Ala Phe Asn Thr Val Val Asn Phe Thr Tyr Ala Val His Asn 
                85                  90                  95      


Glu Trp Tyr Tyr Gly Leu Phe Tyr Cys Lys Phe His Asn Phe Phe Pro 
            100                 105                 110         


Ile Ala Ala Val Phe Ala Ser Ile Tyr Ser Met Thr Ala Val Ala Phe 
        115                 120                 125             


Val Arg Tyr Met Ala Ile Ile His Pro Leu Gln Pro Arg Leu Ser Ala 
    130                 135                 140                 


Thr Ala Thr Lys Val Val Ile Cys Val Ile Trp Val Leu Ala Leu Leu 
145                 150                 155                 160 


Leu Ala Phe Pro Gln Gly Tyr Tyr Ser Thr Thr Glu Thr Met Pro Ser 
                165                 170                 175     


Arg Val Val Cys Lys Ile Glu Trp Pro Glu His Pro Asn Lys Ile Tyr 
            180                 185                 190         


Glu Lys Val Tyr His Ile Cys Val Thr Val Leu Ile Tyr Phe Leu Pro 
        195                 200                 205             


Leu Leu Val Ile Gly Tyr Ala Tyr Thr Val Val Gly Ile Arg Leu Trp 
    210                 215                 220                 


Ala Ser Glu Ile Pro Gly Asp Ser Ser Asp Arg Tyr His Glu Gln Val 
225                 230                 235                 240 


Ser Ala Lys Arg Lys Val Val Lys Met Met Ile Val Val Val Cys Thr 
                245                 250                 255     


Phe Ala Ile Cys Trp Leu Pro Tyr His Ile Phe Phe Leu Leu Pro Tyr 
            260                 265                 270         


Ile Asn Pro Asp Leu Tyr Leu Lys Lys Phe Ile Gln Gln Val Tyr Leu 
        275                 280                 285             


Ala Ile Met Trp Leu Ala Met Ser Ser Thr Met Tyr Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Cys Cys Leu Asn Asp Arg Phe Arg Leu Gly Phe Lys His Ala Phe 
305                 310                 315                 320 


Arg Trp Cys Pro Phe Ile Ser Ala Gly Asp Tyr Glu Gly Leu Lys Met 
                325                 330                 335     


Lys Ser Thr Arg Tyr Leu Gln Thr Gln Gly Ser Val Tyr Lys Val Ser 
            340                 345                 350         


Arg Leu Glu Thr Thr Ile Ser Thr Val Val Gly Ala His Glu Glu Glu 
        355                 360                 365             


Pro Glu Asp Gly Pro Lys Ala Thr Pro Ser Ser Leu Asp Leu Thr Ser 
    370                 375                 380                 


Asn Cys Ser Ser Arg Ser Asp Ser Lys Thr Met Thr Glu Ser Phe Ser 
385                 390                 395                 400 


Phe Ser Ser Asn Val Leu Ser 
                405         


<210>  26
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Asp Ser Pro Ile Gln Ile Phe Arg Gly Glu Pro Gly Pro Thr Cys 
1               5                   10                  15      


Ala Pro Ser Ala Cys Leu Pro Pro Asn Ser Ser Ala Trp Phe Pro Gly 
            20                  25                  30          


Trp Ala Glu Pro Asp Ser Asn Gly Ser Ala Gly Ser Glu Asp Ala Gln 
        35                  40                  45              


Leu Glu Pro Ala His Ile Ser Pro Ala Ile Pro Val Ile Ile Thr Ala 
    50                  55                  60                  


Val Tyr Ser Val Val Phe Val Val Gly Leu Val Gly Asn Ser Leu Val 
65                  70                  75                  80  


Met Phe Val Ile Ile Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile 
                85                  90                  95      


Tyr Ile Phe Asn Leu Ala Leu Ala Asp Ala Leu Val Thr Thr Thr Met 
            100                 105                 110         


Pro Phe Gln Ser Thr Val Tyr Leu Met Asn Ser Trp Pro Phe Gly Asp 
        115                 120                 125             


Val Leu Cys Lys Ile Val Ile Ser Ile Asp Tyr Tyr Asn Met Phe Thr 
    130                 135                 140                 


Ser Ile Phe Thr Leu Thr Met Met Ser Val Asp Arg Tyr Ile Ala Val 
145                 150                 155                 160 


Cys His Pro Val Lys Ala Leu Asp Phe Arg Thr Pro Leu Lys Ala Lys 
                165                 170                 175     


Ile Ile Asn Ile Cys Ile Trp Leu Leu Ser Ser Ser Val Gly Ile Ser 
            180                 185                 190         


Ala Ile Val Leu Gly Gly Thr Lys Val Arg Glu Asp Val Asp Val Ile 
        195                 200                 205             


Glu Cys Ser Leu Gln Phe Pro Asp Asp Asp Tyr Ser Trp Trp Asp Leu 
    210                 215                 220                 


Phe Met Lys Ile Cys Val Phe Ile Phe Ala Phe Val Ile Pro Val Leu 
225                 230                 235                 240 


Ile Ile Ile Val Cys Tyr Thr Leu Met Ile Leu Arg Leu Lys Ser Val 
                245                 250                 255     


Arg Leu Leu Ser Gly Ser Arg Glu Lys Asp Arg Asn Leu Arg Arg Ile 
            260                 265                 270         


Thr Arg Leu Val Leu Val Val Val Ala Val Phe Val Val Cys Trp Thr 
        275                 280                 285             


Pro Ile His Ile Phe Ile Leu Val Glu Ala Leu Gly Ser Thr Ser His 
    290                 295                 300                 


Ser Thr Ala Ala Leu Ser Ser Tyr Tyr Phe Cys Ile Ala Leu Gly Tyr 
305                 310                 315                 320 


Thr Asn Ser Ser Leu Asn Pro Ile Leu Tyr Ala Phe Leu Asp Glu Asn 
                325                 330                 335     


Phe Lys Arg Cys Phe Arg Asp Phe Cys Phe Pro Leu Lys Met Arg Met 
            340                 345                 350         


Glu Arg Gln Ser Thr Ser Arg Val Arg Asn Thr Val Gln Asp Pro Ala 
        355                 360                 365             


Tyr Leu Arg Asp Ile Asp Gly Met Asn Lys Pro Val 
    370                 375                 380 


<210>  27
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Asp Ser Pro Ile Gln Ile Phe Arg Gly Glu Pro Gly Pro Thr Cys 
1               5                   10                  15      


Ala Pro Ser Ala Cys Leu Pro Pro Asn Ser Ser Ala Trp Phe Pro Gly 
            20                  25                  30          


Trp Ala Glu Pro Asp Ser Asn Gly Ser Ala Gly Ser Glu Asp Ala Gln 
        35                  40                  45              


Leu Glu Pro Ala His Ile Ser Pro Ala Ile Pro Val Ile Ile Thr Ala 
    50                  55                  60                  


Val Tyr Ser Val Val Phe Val Val Gly Leu Val Gly Asn Ser Leu Val 
65                  70                  75                  80  


Met Phe Val Ile Ile Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile 
                85                  90                  95      


Tyr Ile Phe Asn Leu Ala Leu Ala Asp Ala Leu Val Thr Ala Thr Met 
            100                 105                 110         


Pro Phe Gln Ser Thr Asp Tyr Leu Met Asn Ser Trp Pro Phe Gly Asp 
        115                 120                 125             


Val Leu Cys Lys Ile Val Ile Ser Ile Asp Tyr Tyr Ser Met Phe Thr 
    130                 135                 140                 


Ser Ile Phe Thr Leu Thr Met Met Cys Val Asp Arg Tyr Ile Ala Val 
145                 150                 155                 160 


Cys His Pro Val Lys Ala Leu Asp Phe Arg Thr Pro Leu Lys Ala Lys 
                165                 170                 175     


Ile Ile Asn Ile Cys Ile Trp Leu Leu Ser Ser Ser Val Gly Ile Ser 
            180                 185                 190         


Ala Ile Val Leu Gly Gly Thr Lys Val Arg Glu Asp Val Asp Val Ile 
        195                 200                 205             


Glu Cys Ser Leu Gln Phe Pro Asp Asp Asp Tyr Ser Trp Trp Asp Leu 
    210                 215                 220                 


Phe Met Lys Ile Cys Val Phe Ile Phe Ala Phe Val Ile Pro Val Leu 
225                 230                 235                 240 


Ile Ile Ile Val Cys Tyr Thr Leu Met Ile Leu Arg Leu Lys Ser Val 
                245                 250                 255     


Arg Leu Leu Ser Gly Ser Arg Glu Lys Asp Arg Asn Leu Arg Arg Ile 
            260                 265                 270         


Thr Arg Leu Val Leu Val Val Val Ala Val Phe Val Val Cys Trp Thr 
        275                 280                 285             


Pro Ile His Ile Phe Ile Leu Val Glu Ala Leu Gly Ser Thr Ser His 
    290                 295                 300                 


Ser Thr Ala Ala Leu Ser Ser Tyr Tyr Phe Cys Ile Ala Leu Gly Tyr 
305                 310                 315                 320 


Ile Asn Ser Ser Leu Asn Pro Ile Leu Tyr Ala Phe Leu Asp Glu Asn 
                325                 330                 335     


Phe Lys Arg Cys Phe Arg Asp Phe Cys Phe Pro Leu Lys Met Arg Met 
            340                 345                 350         


Lys Arg Gln Ser Thr Ser Arg Val Arg Asn Thr Val Gln Asp Pro Ala 
        355                 360                 365             


Tyr Leu Arg Asp Ile Asp Gly Met Asn Lys Pro Val 
    370                 375                 380 


<210>  28
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Asp Ser Pro Ile Gln Ile Phe Arg Arg Glu Pro Gly Pro Thr Cys 
1               5                   10                  15      


Ala Pro Ser Ala Cys Leu Pro Pro Asn Ser Ser Ala Trp Phe Pro Gly 
            20                  25                  30          


Trp Ala Glu Pro Asp Ser Asn Gly Ser Ala Gly Ser Glu Asp Ala Gln 
        35                  40                  45              


Leu Glu Pro Ala His Ile Ser Pro Ala Ile Pro Val Ile Ile Thr Ala 
    50                  55                  60                  


Val Tyr Ser Val Val Phe Val Val Gly Leu Val Gly Asn Ser Leu Val 
65                  70                  75                  80  


Met Phe Val Ile Ile Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile 
                85                  90                  95      


Tyr Ile Phe Ser Leu Ala Leu Ala Gly Ala Leu Val Thr Thr Thr Met 
            100                 105                 110         


Pro Phe Gln Ser Thr Asp Tyr Leu Met Asn Ser Trp Pro Phe Gly Asp 
        115                 120                 125             


Val Leu Cys Lys Ile Val Ile Ser Ile Asp Tyr Tyr Ser Met Phe Thr 
    130                 135                 140                 


Ser Ile Phe Thr Leu Thr Met Met Cys Val Asp Arg Tyr Ile Ala Val 
145                 150                 155                 160 


Cys His Pro Val Lys Ala Leu Asp Phe Arg Thr Pro Leu Lys Ala Lys 
                165                 170                 175     


Ile Ile Asn Ile Cys Ile Trp Leu Leu Ser Ser Ser Val Gly Ile Ser 
            180                 185                 190         


Ala Ile Val Leu Gly Gly Thr Lys Val Arg Glu Asp Val Asp Val Ile 
        195                 200                 205             


Glu Cys Ser Leu Gln Phe Pro Asp Asp Asp Tyr Ser Trp Trp Asp Leu 
    210                 215                 220                 


Phe Met Lys Ile Cys Val Phe Ile Phe Ala Phe Val Ile Pro Val Leu 
225                 230                 235                 240 


Ile Ile Ile Val Cys Tyr Thr Leu Met Ile Leu Arg Leu Lys Ser Val 
                245                 250                 255     


Arg Leu Leu Ser Gly Ser Arg Glu Lys Asp Arg Asn Leu Arg Arg Ile 
            260                 265                 270         


Thr Arg Leu Val Leu Val Val Val Ala Val Phe Val Val Cys Trp Thr 
        275                 280                 285             


Pro Ile His Ile Phe Ile Leu Val Glu Ala Leu Gly Gly Thr Ser His 
    290                 295                 300                 


Ser Thr Ala Ala Leu Ser Ser Tyr Tyr Phe Cys Ile Ala Leu Gly Tyr 
305                 310                 315                 320 


Ile Asn Ser Ser Leu Asn Pro Ile Leu Tyr Ala Phe Leu Asp Glu Asn 
                325                 330                 335     


Phe Lys Arg Cys Phe Arg Asp Phe Cys Phe Pro Leu Lys Met Arg Met 
            340                 345                 350         


Lys Arg Gln Ser Thr Ser Arg Val Arg Asn Thr Val Gln Asp Pro Ala 
        355                 360                 365             


Tyr Leu Arg Asp Ile Asp Gly Met Asn Lys Pro Val 
    370                 375                 380 


<210>  29
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Asp Ser Pro Ile Gln Ile Phe Arg Gly Glu Pro Gly Pro Thr Cys 
1               5                   10                  15      


Ala Pro Ser Ala Cys Leu Pro Pro Asn Ser Ser Ala Trp Phe Pro Gly 
            20                  25                  30          


Trp Ala Glu Pro Asp Ser Asn Gly Ser Ala Gly Ser Glu Asp Ala Gln 
        35                  40                  45              


Leu Glu Pro Ala His Ile Ser Pro Ala Ile Pro Val Ile Ile Thr Ala 
    50                  55                  60                  


Val Tyr Ser Val Val Phe Val Val Gly Leu Val Gly Asn Ser Leu Val 
65                  70                  75                  80  


Met Phe Val Ile Ile Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile 
                85                  90                  95      


Tyr Ile Phe Ser Leu Ala Leu Ala Gly Ala Leu Val Thr Thr Thr Met 
            100                 105                 110         


Pro Phe Gln Ser Thr Asp Tyr Leu Met Asn Ser Trp Pro Phe Gly Asp 
        115                 120                 125             


Val Leu Cys Lys Ile Val Ile Ser Ile Asp Tyr Tyr Ser Met Phe Thr 
    130                 135                 140                 


Ser Ile Phe Thr Leu Thr Met Met Cys Val Asp Arg Tyr Ile Ala Val 
145                 150                 155                 160 


Cys His Pro Val Lys Ala Leu Asp Phe Arg Thr Pro Leu Lys Ala Lys 
                165                 170                 175     


Ile Ile Asn Ile Cys Ile Trp Leu Leu Ser Ser Ser Val Gly Ile Ser 
            180                 185                 190         


Ala Ile Val Leu Gly Gly Thr Lys Val Arg Glu Asp Val Asp Val Ile 
        195                 200                 205             


Glu Cys Ser Leu Gln Phe Pro Asp Asp Asp Tyr Ser Trp Trp Asp Leu 
    210                 215                 220                 


Phe Met Lys Ile Cys Val Phe Ile Phe Ala Phe Val Ile Pro Val Leu 
225                 230                 235                 240 


Ile Ile Ile Val Cys Tyr Thr Leu Met Ile Leu Arg Leu Lys Ser Val 
                245                 250                 255     


Arg Leu Leu Ser Gly Ser Arg Glu Lys Asp Arg Asn Leu Arg Arg Ile 
            260                 265                 270         


Thr Arg Leu Val Leu Val Val Val Ala Val Phe Val Val Cys Trp Thr 
        275                 280                 285             


Pro Ile His Ile Phe Ile Leu Val Glu Ala Leu Gly Ser Thr Ser His 
    290                 295                 300                 


Ser Thr Ala Ala Leu Ser Ser Tyr Tyr Phe Cys Ile Ala Leu Gly Tyr 
305                 310                 315                 320 


Ile Asn Ser Ser Leu Asn Pro Ile Leu Tyr Ala Phe Leu Asp Glu Asn 
                325                 330                 335     


Phe Lys Arg Cys Phe Arg Asp Phe Cys Phe Pro Leu Lys Met Arg Met 
            340                 345                 350         


Lys Arg Gln Ser Thr Ser Arg Val Arg Asn Thr Val Gln Asp Pro Ala 
        355                 360                 365             


Tyr Leu Arg Asp Ile Asp Gly Met Asn Lys Pro Val 
    370                 375                 380 


<210>  30
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Asp Ser Pro Ile Gln Ile Phe Arg Gly Glu Pro Gly Pro Thr Cys 
1               5                   10                  15      


Ala Pro Ser Ala Cys Leu Pro Arg Asn Ser Ser Ala Trp Phe Pro Gly 
            20                  25                  30          


Trp Ala Glu Pro Asp Ser Asn Gly Ser Ala Gly Ser Glu Asp Ala Gln 
        35                  40                  45              


Leu Glu Pro Ala His Ile Ser Pro Ala Ile Pro Val Ile Ile Thr Ala 
    50                  55                  60                  


Val Tyr Ser Val Val Phe Val Val Gly Leu Val Gly Asn Ser Leu Val 
65                  70                  75                  80  


Met Phe Val Ile Ile Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile 
                85                  90                  95      


Tyr Ile Phe Ser Leu Ala Leu Ala Gly Ala Leu Val Thr Thr Thr Met 
            100                 105                 110         


Pro Phe Gln Ser Thr Asp Tyr Leu Met Asn Ser Trp Pro Phe Gly Asp 
        115                 120                 125             


Val Leu Cys Lys Ile Val Ile Ser Ile Asp Tyr Tyr Ser Met Phe Thr 
    130                 135                 140                 


Ser Ile Phe Thr Leu Thr Met Met Cys Val Asp Arg Tyr Ile Ala Val 
145                 150                 155                 160 


Cys His Pro Val Lys Ala Leu Asp Phe Arg Thr Pro Leu Lys Ala Lys 
                165                 170                 175     


Ile Ile Asn Ile Cys Ile Trp Leu Leu Ser Ser Ser Val Gly Ile Ser 
            180                 185                 190         


Ala Ile Val Leu Gly Gly Thr Lys Val Arg Glu Asp Val Asp Val Ile 
        195                 200                 205             


Glu Cys Ser Leu Gln Phe Pro Asp Asp Asp Tyr Ser Trp Trp Asp Leu 
    210                 215                 220                 


Phe Met Lys Ile Cys Val Phe Ile Phe Ala Phe Val Ile Pro Val Leu 
225                 230                 235                 240 


Ile Ile Ile Val Cys Tyr Thr Leu Met Ile Leu Arg Leu Lys Ser Val 
                245                 250                 255     


Arg Leu Leu Ser Gly Ser Arg Glu Lys Asp Arg Asn Leu Arg Arg Ile 
            260                 265                 270         


Thr Arg Leu Val Leu Val Val Val Ala Val Phe Val Val Cys Trp Thr 
        275                 280                 285             


Pro Ile His Ile Phe Ile Leu Val Glu Ala Leu Gly Ser Thr Ser His 
    290                 295                 300                 


Ser Thr Ala Ala Leu Ser Ser Tyr Tyr Phe Cys Ile Ala Leu Gly Tyr 
305                 310                 315                 320 


Ile Asn Ser Ser Leu Asn Pro Ile Leu Tyr Ala Phe Leu Asp Glu Asn 
                325                 330                 335     


Phe Lys Arg Cys Phe Arg Asp Phe Cys Phe Pro Leu Lys Met Arg Met 
            340                 345                 350         


Lys Arg Gln Ser Thr Ser Arg Val Arg Asn Thr Val Gln Asp Pro Ala 
        355                 360                 365             


Tyr Leu Arg Asp Ile Asp Gly Met Asn Lys Pro Val 
    370                 375                 380 


<210>  31
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Asp Ser Pro Ile Gln Ile Phe Arg Gly Glu Pro Gly Pro Thr Cys 
1               5                   10                  15      


Ala Pro Ser Ala Cys Leu Pro Pro Asn Ser Ser Ala Trp Phe Pro Gly 
            20                  25                  30          


Trp Ala Glu Pro Asp Ser Asn Gly Ser Ala Gly Ser Glu Asp Ala Gln 
        35                  40                  45              


Leu Glu Pro Ala His Ile Ser Pro Ala Ile Pro Val Ile Ile Thr Ala 
    50                  55                  60                  


Val Tyr Ser Val Val Phe Val Val Gly Leu Val Gly Asn Ser Leu Val 
65                  70                  75                  80  


Met Phe Val Ile Ile Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile 
                85                  90                  95      


Tyr Ile Phe Ser Leu Ala Leu Ala Gly Ala Leu Val Thr Thr Thr Met 
            100                 105                 110         


Pro Phe Gln Ser Thr Asp Tyr Leu Met Asn Ser Trp Pro Phe Gly Asp 
        115                 120                 125             


Val Leu Cys Lys Ile Val Ile Ser Ile Asp Tyr Tyr Ser Met Phe Thr 
    130                 135                 140                 


Ser Ile Phe Thr Leu Thr Met Met Cys Val Asp Arg Tyr Ile Ala Val 
145                 150                 155                 160 


Cys His Pro Val Lys Ala Leu Asp Phe Arg Thr Pro Leu Lys Ala Lys 
                165                 170                 175     


Ile Ile Asn Ile Cys Ile Trp Leu Leu Ser Ser Ser Val Gly Ile Ser 
            180                 185                 190         


Ala Ile Val Leu Gly Gly Thr Lys Val Arg Glu Asp Val Asp Val Ile 
        195                 200                 205             


Glu Cys Ser Leu Gln Phe Pro Asp Asp Asp Tyr Ser Trp Trp Asp Leu 
    210                 215                 220                 


Phe Met Lys Ile Cys Val Phe Ile Phe Ala Phe Val Ile Pro Val Leu 
225                 230                 235                 240 


Ile Ile Ile Val Cys Tyr Thr Leu Met Ile Leu Arg Leu Lys Ser Val 
                245                 250                 255     


Arg Leu Leu Ser Gly Ser Arg Glu Lys Asp Arg Asn Leu Arg Arg Ile 
            260                 265                 270         


Thr Arg Leu Val Leu Val Val Val Val Val Phe Val Val Cys Trp Thr 
        275                 280                 285             


Pro Ile His Ile Phe Ile Leu Val Glu Ala Leu Gly Ser Thr Ser His 
    290                 295                 300                 


Ser Thr Ala Ala Leu Ser Ser Tyr Tyr Phe Cys Ile Ala Leu Gly Tyr 
305                 310                 315                 320 


Ile Asn Ser Ser Leu Asn Pro Ile Leu Tyr Ala Phe Leu Asp Glu Asn 
                325                 330                 335     


Phe Lys Arg Cys Phe Arg Asp Phe Cys Phe Pro Leu Lys Met Arg Met 
            340                 345                 350         


Lys Arg Gln Ser Thr Ser Arg Val Arg Asn Thr Val Gln Asp Pro Ala 
        355                 360                 365             


Tyr Leu Arg Asp Ile Asp Gly Met Asn Lys Pro Val 
    370                 375                 380 


<210>  32
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Asp Ser Pro Ile Gln Ile Phe Arg Gly Glu Pro Gly Pro Thr Cys 
1               5                   10                  15      


Ala Pro Ser Ala Cys Leu Pro Pro Asn Ser Ser Ala Trp Phe Pro Gly 
            20                  25                  30          


Trp Ala Glu Pro Asp Ser Asn Gly Ser Ala Gly Ser Glu Asp Ala Gln 
        35                  40                  45              


Leu Glu Pro Ala His Ile Ser Pro Ala Ile Pro Val Ile Ile Thr Ala 
    50                  55                  60                  


Val Tyr Ser Val Val Phe Val Val Gly Leu Val Gly Asn Ser Leu Val 
65                  70                  75                  80  


Met Phe Val Ile Ile Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile 
                85                  90                  95      


Tyr Ile Phe Ser Leu Ala Leu Ala Gly Ala Leu Val Thr Thr Thr Met 
            100                 105                 110         


Pro Phe Gln Ser Thr Asp Tyr Leu Met Asn Ser Trp Pro Phe Gly Asp 
        115                 120                 125             


Val Leu Cys Lys Ile Val Ile Ser Ile Asp Tyr Tyr Ser Met Phe Thr 
    130                 135                 140                 


Ser Ile Phe Thr Leu Thr Met Met Cys Val Asp His Tyr Ile Ala Val 
145                 150                 155                 160 


Cys His Pro Val Lys Ala Leu Asp Phe Arg Thr Pro Leu Lys Ala Lys 
                165                 170                 175     


Ile Ile Asn Ile Cys Ile Trp Leu Leu Ser Ser Ser Val Gly Ile Ser 
            180                 185                 190         


Ala Ile Val Leu Gly Gly Thr Lys Val Arg Asp Asp Val Asp Val Ile 
        195                 200                 205             


Glu Cys Ser Leu Gln Phe Pro Asp Asp Asp Tyr Ser Trp Trp Asp Leu 
    210                 215                 220                 


Phe Met Lys Ile Cys Val Phe Ile Phe Ala Phe Val Ile Pro Val Leu 
225                 230                 235                 240 


Ile Ile Ile Val Cys Tyr Thr Leu Met Ile Leu Arg Leu Lys Ser Val 
                245                 250                 255     


Arg Leu Leu Ser Gly Ser Arg Glu Lys Asp Arg Asn Leu Arg Arg Ile 
            260                 265                 270         


Thr Arg Leu Val Leu Val Val Val Ala Val Phe Val Val Cys Trp Thr 
        275                 280                 285             


Pro Ile His Ile Phe Ile Leu Val Glu Ala Leu Gly Ser Thr Ser His 
    290                 295                 300                 


Ser Thr Ala Ala Leu Ser Ser Tyr Tyr Phe Cys Ile Ala Leu Gly Tyr 
305                 310                 315                 320 


Ile Asn Ser Ser Leu Asn Pro Ile Leu Tyr Ala Phe Leu Asp Glu Asn 
                325                 330                 335     


Phe Lys Arg Cys Phe Arg Asp Phe Cys Phe Pro Leu Lys Met Arg Met 
            340                 345                 350         


Lys Arg Gln Ser Thr Ser Arg Val Arg Asn Thr Val Gln Asp Pro Ala 
        355                 360                 365             


Tyr Leu Arg Asp Ile Asp Gly Met Asn Lys Pro Val 
    370                 375                 380 


<210>  33
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Asp Ser Pro Ile Gln Ile Ile Arg Gly Glu Pro Gly Pro Thr Cys 
1               5                   10                  15      


Ala Pro Ser Ala Cys Leu Pro Pro Asn Ser Ser Ala Trp Phe Pro Gly 
            20                  25                  30          


Trp Ala Glu Pro Asp Ser Asn Gly Ser Ala Gly Ser Glu Asp Ala Gln 
        35                  40                  45              


Leu Glu Pro Ala His Ile Pro Pro Ala Ile Pro Val Ile Ile Thr Ala 
    50                  55                  60                  


Val Tyr Ser Val Val Phe Val Val Gly Leu Val Gly Asn Ser Leu Val 
65                  70                  75                  80  


Met Phe Val Ile Ile Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile 
                85                  90                  95      


Tyr Ile Phe Ser Leu Ala Leu Ala Gly Ala Leu Val Thr Thr Thr Met 
            100                 105                 110         


Pro Phe Gln Ser Thr Asp Tyr Leu Met Asn Ser Trp Pro Phe Gly Asp 
        115                 120                 125             


Val Leu Cys Lys Ile Val Ile Ser Thr Asp Tyr Tyr Ser Met Phe Thr 
    130                 135                 140                 


Ser Ile Phe Thr Leu Thr Met Met Cys Val Asp Arg Tyr Ile Ala Val 
145                 150                 155                 160 


Cys His Pro Val Lys Ala Leu Asp Phe Arg Thr Pro Leu Lys Ala Lys 
                165                 170                 175     


Ile Ile Asn Ile Cys Ile Trp Leu Leu Ser Ser Ser Val Gly Ile Ser 
            180                 185                 190         


Ala Ile Val Leu Gly Gly Thr Lys Val Arg Glu Asp Val Asp Val Ile 
        195                 200                 205             


Glu Cys Ser Leu Gln Phe Pro Asp Asp Asp Tyr Ser Trp Trp Asp Leu 
    210                 215                 220                 


Phe Met Lys Ile Cys Val Phe Ile Phe Ala Phe Val Ile Pro Val Leu 
225                 230                 235                 240 


Ile Ile Ile Val Cys Tyr Thr Leu Met Ile Leu Arg Leu Lys Ser Val 
                245                 250                 255     


Arg Leu Leu Ser Gly Ser Arg Glu Lys Asp Arg Asn Leu Arg Arg Ile 
            260                 265                 270         


Thr Arg Leu Val Leu Val Val Val Ala Val Phe Val Val Cys Trp Thr 
        275                 280                 285             


Pro Ile His Ile Phe Ile Leu Val Glu Ala Leu Gly Ser Thr Ser His 
    290                 295                 300                 


Ser Thr Ala Ala Leu Ser Ser Tyr Tyr Phe Cys Ile Ala Leu Gly Tyr 
305                 310                 315                 320 


Ile Asn Ser Ser Leu Asn Pro Ile Leu Tyr Ala Phe Leu Asp Glu Asn 
                325                 330                 335     


Phe Lys Arg Cys Phe Arg Asp Phe Cys Phe Pro Leu Lys Met Arg Met 
            340                 345                 350         


Lys Arg Gln Ser Thr Ser Arg Val Arg Asn Thr Val Gln Asp Pro Ala 
        355                 360                 365             


Tyr Leu Arg Asp Ile Asp Gly Met Asp Lys Pro Val 
    370                 375                 380 


