                         SEQUENCE LISTING

<110>  Carlsberg Breweries A/S
 
<120>  Yeast for preparing alcoholic beverages

<130>  P3410PC00

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  520
<212>  PRT
<213>  Hybrid yeast_1

<400>  1

Met Gly Tyr Asp Ile Ala Asn Tyr Glu Lys Val Trp Pro Thr Tyr Gly 
1               5                   10                  15      


Thr Asn Glu Asp Cys Phe Ala Leu Ile Glu Lys Thr His Lys Leu Gly 
            20                  25                  30          


Met Lys Phe Ile Thr Asp Leu Val Ile Asn His Cys Ser Ser Glu His 
        35                  40                  45              


Glu Trp Phe Lys Glu Ser Arg Ser Ser Lys Thr Asn Pro Lys Arg Asp 
    50                  55                  60                  


Trp Phe Phe Trp Arg Pro Pro Lys Gly Tyr Asp Ala Glu Gly Lys Pro 
65                  70                  75                  80  


Ile Pro Pro Asn Asn Trp Lys Ser Tyr Phe Gly Gly Ser Ala Trp Thr 
                85                  90                  95      


Phe Asp Glu Lys Thr Gln Glu Phe Tyr Leu Arg Leu Phe Cys Ser Thr 
            100                 105                 110         


Gln Pro Asp Leu Asn Trp Glu Asn Glu Asp Cys Arg Lys Ala Ile Tyr 
        115                 120                 125             


Glu Ser Ala Val Gly Tyr Trp Leu Asp His Gly Val Asp Gly Phe Arg 
    130                 135                 140                 


Ile Asp Val Gly Ser Leu Tyr Ser Lys Val Val Gly Leu Pro Asp Ala 
145                 150                 155                 160 


Pro Val Val Asp Lys Asn Ser Thr Trp Gln Ser Ser Asp Pro Tyr Thr 
                165                 170                 175     


Leu Asn Gly Pro Arg Ile His Glu Phe His Gln Glu Met Asn Gln Phe 
            180                 185                 190         


Ile Arg Asn Arg Val Lys Asp Gly Arg Glu Ile Met Thr Val Gly Glu 
        195                 200                 205             


Met Gln His Ala Ser Asp Glu Thr Lys Arg Leu Tyr Thr Ser Ala Ser 
    210                 215                 220                 


Arg His Glu Leu Ser Glu Leu Phe Asn Phe Ser His Thr Asp Val Gly 
225                 230                 235                 240 


Thr Ser Pro Leu Phe Arg Tyr Asn Leu Val Pro Phe Glu Leu Lys Asp 
                245                 250                 255     


Trp Lys Ile Ala Leu Ala Glu Leu Phe Arg Tyr Ile Asn Gly Thr Asp 
            260                 265                 270         


Cys Trp Ser Thr Ile Tyr Leu Glu Asn His Asp Gln Pro Arg Ser Ile 
        275                 280                 285             


Thr Arg Phe Gly Asp Asp Ser Pro Lys Asn Arg Val Ile Ser Gly Lys 
    290                 295                 300                 


Leu Leu Ser Val Leu Leu Ser Ala Leu Thr Gly Thr Leu Tyr Val Tyr 
305                 310                 315                 320 


Gln Gly Gln Glu Leu Gly Gln Ile Asn Phe Lys Asn Trp Pro Val Glu 
                325                 330                 335     


Lys Tyr Glu Asp Val Glu Ile Arg Asn Asn Tyr Asn Ala Ile Lys Glu 
            340                 345                 350         


Glu His Gly Glu Asn Ser Glu Glu Met Lys Lys Phe Leu Glu Gly Ile 
        355                 360                 365             


Ala Leu Val Ser Arg Asp His Ala Arg Thr Pro Met Pro Trp Thr Pro 
    370                 375                 380                 


Asn Glu Pro Asn Ala Gly Phe Ser Gly Pro Asn Thr Lys Pro Trp Phe 
385                 390                 395                 400 


Tyr Leu Asn Glu Ser Phe Arg Gln Gly Ile Asn Val Glu Glu Glu Gln 
                405                 410                 415     


Lys Asn Ser Asp Ser Val Leu Ala Phe Trp Lys Lys Ala Leu Glu Phe 
            420                 425                 430         


Arg Lys Asn His Lys Asp Ile Ala Val Tyr Gly Phe Asp Phe Lys Phe 
        435                 440                 445             


Ile Asp Leu Asp Asn Lys Lys Leu Phe Ser Phe Thr Lys Arg Tyr Asn 
    450                 455                 460                 


Asn Lys Thr Leu Phe Ala Ala Leu Asn Phe Ser Ser Asp Ala Thr Asp 
465                 470                 475                 480 


Phe Lys Ile Pro Asn Asp Gly Ser Ser Phe Lys Leu Glu Phe Gly Asn 
                485                 490                 495     


Tyr Pro Lys Asn Glu Val Asp Ala Ser Ser Arg Thr Leu Lys Pro Trp 
            500                 505                 510         


Glu Gly Arg Ile His Ile Asn Glu 
        515                 520 


<210>  2
<211>  520
<212>  PRT
<213>  Hybrid yeast 4

<400>  2

Met Gly Tyr Asp Ile Ala Asn Tyr Glu Lys Val Trp Pro Thr Tyr Gly 
1               5                   10                  15      


Thr Asn Glu Asp Cys Phe Ala Leu Ile Glu Lys Thr His Lys Leu Gly 
            20                  25                  30          


Met Lys Phe Ile Thr Asp Leu Val Ile Asn His Cys Ser Ser Glu His 
        35                  40                  45              


Glu Trp Phe Lys Glu Ser Arg Ser Ser Lys Thr Asn Pro Lys Arg Asp 
    50                  55                  60                  


Trp Phe Phe Trp Arg Pro Pro Lys Gly Tyr Asp Ala Glu Gly Lys Pro 
65                  70                  75                  80  


Ile Pro Pro Asn Asn Trp Lys Ser Tyr Phe Gly Gly Ser Ala Trp Thr 
                85                  90                  95      


Phe Asp Glu Lys Thr Gln Glu Phe Tyr Leu Arg Leu Phe Cys Ser Thr 
            100                 105                 110         


Gln Pro Asp Leu Asn Trp Glu Asn Glu Asp Cys Arg Lys Ala Ile Tyr 
        115                 120                 125             


Glu Ser Ala Val Gly Tyr Trp Leu Asp His Gly Val Asp Gly Phe Arg 
    130                 135                 140                 


Ile Asp Val Gly Ser Leu Tyr Ser Lys Val Val Gly Leu Pro Asp Ala 
145                 150                 155                 160 


Pro Val Val Asp Lys Asn Ser Thr Trp Gln Ser Ser Asp Pro Tyr Thr 
                165                 170                 175     


Leu Asn Gly Pro Arg Ile His Glu Phe His Gln Glu Met Asn Gln Phe 
            180                 185                 190         


Ile Arg Asn Arg Val Lys Asp Gly Arg Glu Ile Met Thr Val Gly Glu 
        195                 200                 205             


Met Gln His Ala Ser Asp Glu Thr Lys Arg Leu Tyr Thr Ser Ala Ser 
    210                 215                 220                 


Arg His Glu Leu Ser Glu Leu Phe Asn Phe Ser His Thr Asp Val Gly 
225                 230                 235                 240 


Thr Ser Pro Leu Phe Arg Tyr Asn Leu Val Pro Phe Glu Leu Lys Asp 
                245                 250                 255     


Trp Lys Ile Ala Leu Ala Glu Leu Phe Arg Tyr Ile Asn Gly Thr Asp 
            260                 265                 270         


Cys Trp Ser Thr Ile Tyr Leu Glu Asn His Asp Gln Pro Arg Ser Ile 
        275                 280                 285             


Thr Arg Phe Gly Asp Asp Ser Pro Lys Asn Arg Val Ile Ser Gly Lys 
    290                 295                 300                 


Leu Leu Ser Val Leu Leu Ser Ala Leu Thr Gly Thr Leu Tyr Val Tyr 
305                 310                 315                 320 


Gln Gly Gln Glu Leu Gly Gln Ile Asn Phe Lys Asn Trp Pro Val Glu 
                325                 330                 335     


Lys Tyr Glu Asp Val Glu Ile Arg Asn Asn Tyr Asn Ala Ile Lys Glu 
            340                 345                 350         


Glu His Gly Glu Asn Ser Glu Glu Met Lys Lys Phe Leu Glu Gly Ile 
        355                 360                 365             


Ala Leu Val Ser Arg Asp His Ala Arg Thr Pro Met Pro Trp Thr Pro 
    370                 375                 380                 


Asn Glu Pro Asn Ala Gly Phe Ser Gly Pro Asn Thr Lys Pro Trp Phe 
385                 390                 395                 400 


Tyr Leu Asn Glu Ser Phe Arg Gln Gly Ile Asn Val Glu Glu Glu Gln 
                405                 410                 415     


Lys Asn Ser Asp Ser Val Leu Ala Phe Trp Lys Lys Ala Leu Glu Phe 
            420                 425                 430         


Arg Lys Asn His Lys Asp Ile Ala Val Tyr Gly Phe Asp Phe Lys Phe 
        435                 440                 445             


Ile Asp Leu Asp Asn Lys Lys Leu Phe Ser Phe Thr Lys Arg Tyr Asn 
    450                 455                 460                 


Asn Lys Thr Leu Phe Ala Ala Leu Asn Phe Ser Ser Asp Ala Thr Asp 
465                 470                 475                 480 


Phe Lys Ile Pro Asn Asp Gly Ser Ser Phe Lys Leu Glu Phe Gly Asn 
                485                 490                 495     


Tyr Pro Lys Asn Glu Val Asp Ala Ser Ser Arg Thr Leu Lys Pro Trp 
            500                 505                 510         


Glu Gly Arg Ile Tyr Ile Asn Glu 
        515                 520 


<210>  3
<211>  520
<212>  PRT
<213>  Hybrid yeast_4

<400>  3

Met Gly Tyr Asp Ile Ala Asn Tyr Glu Lys Val Trp Pro Thr Tyr Gly 
1               5                   10                  15      


Thr Asn Glu Asp Cys Phe Ala Leu Ile Glu Lys Thr His Lys Leu Gly 
            20                  25                  30          


Met Lys Phe Ile Thr Asp Leu Val Ile Asn His Cys Ser Ser Glu His 
        35                  40                  45              


Glu Trp Phe Lys Glu Ser Arg Ser Ser Lys Thr Asn Pro Lys Arg Asp 
    50                  55                  60                  


Trp Phe Phe Trp Arg Pro Pro Lys Gly Tyr Asp Ala Glu Gly Lys Pro 
65                  70                  75                  80  


Ile Pro Pro Asn Asn Trp Lys Ser Tyr Phe Gly Gly Ser Ala Trp Thr 
                85                  90                  95      


Phe Asp Glu Lys Thr Gln Glu Phe Tyr Leu Arg Leu Phe Cys Ser Thr 
            100                 105                 110         


Gln Pro Asp Leu Asn Trp Glu Asn Glu Asp Cys Arg Lys Ala Ile Tyr 
        115                 120                 125             


Glu Ser Ala Val Gly Tyr Trp Leu Asp His Gly Val Asp Gly Phe Arg 
    130                 135                 140                 


Ile Asp Val Gly Ser Leu Tyr Ser Lys Val Val Gly Leu Pro Asp Ala 
145                 150                 155                 160 


Pro Val Val Asp Lys Asn Ser Thr Trp Gln Ser Ser Asp Pro Tyr Thr 
                165                 170                 175     


Leu Asn Gly Pro Arg Ile His Glu Phe His Gln Glu Met Asn Gln Phe 
            180                 185                 190         


Ile Arg Asn Arg Val Lys Asp Gly Arg Glu Ile Met Thr Val Gly Glu 
        195                 200                 205             


Met Gln His Ala Ser Asp Glu Thr Lys Arg Leu Tyr Thr Ser Ala Ser 
    210                 215                 220                 


Arg His Glu Leu Ser Glu Leu Phe Asn Phe Ser His Thr Asp Val Gly 
225                 230                 235                 240 


Thr Ser Pro Leu Phe Arg Tyr Asn Leu Val Pro Phe Glu Leu Lys Asp 
                245                 250                 255     


Trp Lys Ile Ala Leu Ala Glu Leu Phe Arg Phe Ile Asn Gly Thr Asp 
            260                 265                 270         


Cys Trp Ser Thr Ile Tyr Leu Glu Asn His Asp Gln Pro Arg Ser Ile 
        275                 280                 285             


Thr Arg Phe Gly Asp Asp Ser Pro Lys Asn Arg Val Ile Ser Gly Lys 
    290                 295                 300                 


Leu Leu Ser Val Leu Leu Ser Ala Leu Thr Gly Thr Leu Tyr Val Tyr 
305                 310                 315                 320 


Gln Gly Gln Glu Leu Gly Gln Ile Asn Phe Lys Asn Trp Ser Val Glu 
                325                 330                 335     


Lys Tyr Glu Asp Val Glu Ile Arg Asn Asn Tyr Arg Leu Ile Lys Glu 
            340                 345                 350         


Glu Cys Gly Glu Asn Ser Glu Glu Met Lys Lys Phe Leu Glu Gly Ile 
        355                 360                 365             


Ala Leu Val Ser Arg Asp His Ala Arg Thr Pro Met Pro Trp Thr Pro 
    370                 375                 380                 


Asn Glu Pro Asn Ala Gly Phe Ser Gly Pro Asn Thr Lys Pro Trp Phe 
385                 390                 395                 400 


Tyr Leu Asn Glu Ser Phe Arg Gln Gly Ile Asn Val Glu Glu Glu Gln 
                405                 410                 415     


Lys Asn Ser Asp Ser Val Leu Ala Phe Trp Lys Lys Ala Leu Glu Phe 
            420                 425                 430         


Arg Lys Asn His Lys Asp Ile Ala Val Tyr Gly Phe Asp Phe Lys Phe 
        435                 440                 445             


Ile Asp Leu Asp Asn Lys Lys Leu Phe Ser Phe Thr Lys Arg Tyr Asn 
    450                 455                 460                 


Asn Lys Thr Leu Phe Ala Ala Leu Asn Phe Ser Ser Asp Ala Thr Asp 
465                 470                 475                 480 


Phe Lys Ile Pro Asn Asp Gly Ser Ser Phe Lys Leu Glu Phe Gly Asn 
                485                 490                 495     


Tyr Pro Lys Asn Glu Val Asp Ala Ser Ser Arg Thr Leu Lys Pro Trp 
            500                 505                 510         


Glu Gly Arg Ile His Ile Asn Glu 
        515                 520 


<210>  4
<211>  520
<212>  PRT
<213>  Hybrid yeast_7

<400>  4

Met Gly Tyr Asp Ile Ala Asn Tyr Glu Lys Val Trp Pro Thr Tyr Gly 
1               5                   10                  15      


Thr Asn Glu Asp Cys Phe Ala Leu Ile Glu Lys Thr His Lys Leu Gly 
            20                  25                  30          


Met Lys Phe Ile Thr Asp Leu Val Ile Asn His Cys Ser Ser Glu His 
        35                  40                  45              


Glu Trp Phe Lys Glu Ser Arg Ser Ser Lys Thr Asn Pro Lys Arg Asp 
    50                  55                  60                  


Trp Phe Phe Trp Arg Pro Pro Lys Gly Tyr Asp Ala Glu Gly Lys Pro 
65                  70                  75                  80  


Ile Pro Pro Asn Asn Trp Lys Ser Tyr Phe Gly Gly Ser Ala Trp Thr 
                85                  90                  95      


Phe Asp Glu Lys Thr Gln Glu Phe Tyr Leu Arg Leu Phe Cys Ser Thr 
            100                 105                 110         


Gln Pro Asp Leu Asn Trp Glu Asn Glu Asp Cys Arg Lys Ala Ile Tyr 
        115                 120                 125             


Glu Ser Ala Val Gly Tyr Trp Leu Asp His Gly Val Asp Gly Phe Arg 
    130                 135                 140                 


Ile Asp Val Gly Ser Leu Tyr Ser Lys Val Val Gly Leu Pro Asp Ala 
145                 150                 155                 160 


Pro Val Val Asp Lys Asn Ser Thr Trp Gln Ser Ser Asp Pro Tyr Thr 
                165                 170                 175     


Leu Asn Gly Pro Arg Ile His Glu Phe His Gln Glu Met Asn Gln Phe 
            180                 185                 190         


Ile Arg Asn Arg Val Lys Asp Gly Arg Glu Ile Met Thr Val Gly Glu 
        195                 200                 205             


Met Gln His Ala Ser Asp Glu Thr Lys Arg Leu Tyr Thr Ser Ala Ser 
    210                 215                 220                 


Arg His Glu Leu Ser Glu Leu Phe Asn Phe Ser His Thr Asp Val Gly 
225                 230                 235                 240 


Thr Ser Pro Leu Phe Arg Tyr Asn Leu Val Pro Phe Glu Leu Lys Asp 
                245                 250                 255     


Trp Lys Ile Ala Leu Ala Glu Leu Phe Arg Tyr Ile Asn Gly Thr Asp 
            260                 265                 270         


Cys Trp Ser Thr Ile Tyr Leu Glu Asn His Asp Gln Pro Arg Ser Ile 
        275                 280                 285             


Thr Arg Phe Gly Asp Asp Ser Pro Lys Asn Arg Val Ile Ser Gly Lys 
    290                 295                 300                 


Leu Leu Ser Val Leu Leu Ser Ala Leu Thr Gly Thr Leu Tyr Val Tyr 
305                 310                 315                 320 


Gln Gly Gln Glu Leu Gly Gln Ile Asn Phe Lys Asn Trp Pro Val Glu 
                325                 330                 335     


Lys Tyr Glu Asp Val Glu Ile Arg Asn Asn Tyr Asn Ala Ile Lys Glu 
            340                 345                 350         


Glu His Gly Glu Asn Ser Glu Glu Met Lys Lys Phe Leu Glu Gly Ile 
        355                 360                 365             


Ala Leu Val Ser Arg Asp His Ala Arg Thr Pro Met Pro Trp Thr Pro 
    370                 375                 380                 


Asn Glu Pro Asn Ala Gly Phe Ser Gly Pro Asn Thr Lys Pro Trp Phe 
385                 390                 395                 400 


Tyr Leu Asn Glu Ser Phe Arg Gln Gly Ile Asn Val Glu Glu Glu Gln 
                405                 410                 415     


Lys Asn Ser Asp Ser Val Leu Ala Phe Trp Lys Lys Ala Leu Glu Phe 
            420                 425                 430         


Arg Lys Asn His Lys Asp Ile Ala Val Tyr Gly Phe Asp Phe Lys Phe 
        435                 440                 445             


Ile Asp Leu Asp Asn Lys Lys Leu Phe Ser Phe Thr Lys Arg Tyr Asn 
    450                 455                 460                 


Asn Lys Thr Leu Phe Ala Ala Leu Asn Phe Ser Ser Asp Ala Thr Asp 
465                 470                 475                 480 


Phe Lys Ile Pro Asn Asp Gly Ser Ser Phe Lys Leu Glu Phe Gly Asn 
                485                 490                 495     


Tyr Pro Lys Asn Glu Val Asp Val Ser Ser Arg Thr Leu Lys Pro Trp 
            500                 505                 510         


Glu Gly Arg Ile Tyr Ile Asn Glu 
        515                 520 


<210>  5
<211>  520
<212>  PRT
<213>  Hybrid yeast_7

<400>  5

Met Gly Tyr Asp Ile Ala Asn Tyr Glu Lys Val Trp Pro Thr Tyr Gly 
1               5                   10                  15      


Thr Asn Glu Asp Cys Phe Ala Leu Ile Glu Lys Thr His Lys Leu Gly 
            20                  25                  30          


Met Lys Phe Ile Thr Asp Leu Val Ile Asn His Cys Ser Ser Glu His 
        35                  40                  45              


Glu Trp Phe Lys Glu Ser Arg Ser Ser Lys Thr Asn Pro Lys Arg Asp 
    50                  55                  60                  


Trp Phe Phe Trp Arg Pro Pro Lys Gly Tyr Asp Ala Glu Gly Lys Pro 
65                  70                  75                  80  


Ile Pro Pro Asn Asn Trp Lys Ser Tyr Phe Gly Gly Ser Ala Trp Thr 
                85                  90                  95      


Phe Asp Glu Lys Thr Gln Glu Phe Tyr Leu Arg Leu Phe Cys Ser Thr 
            100                 105                 110         


Gln Pro Asp Leu Asn Trp Glu Asn Glu Asp Cys Arg Lys Ala Ile Tyr 
        115                 120                 125             


Glu Ser Ala Val Gly Tyr Trp Leu Asp His Gly Val Asp Gly Phe Arg 
    130                 135                 140                 


Ile Asp Val Gly Ser Leu Tyr Ser Lys Val Val Gly Leu Pro Asp Ala 
145                 150                 155                 160 


Pro Val Val Asp Lys Asn Ser Thr Trp Gln Ser Ser Asp Pro Tyr Thr 
                165                 170                 175     


Leu Asn Gly Pro Arg Ile His Glu Phe His Gln Glu Met Asn Gln Phe 
            180                 185                 190         


Ile Arg Asn Arg Val Lys Asp Gly Arg Glu Ile Met Thr Val Gly Glu 
        195                 200                 205             


Met Gln His Ala Ser Asp Glu Thr Lys Arg Leu Tyr Thr Ser Ala Ser 
    210                 215                 220                 


Arg His Glu Leu Ser Glu Leu Phe Asn Phe Ser His Thr Asp Val Gly 
225                 230                 235                 240 


Thr Ser Pro Leu Phe Arg Tyr Asn Leu Val Pro Phe Glu Leu Lys Asp 
                245                 250                 255     


Trp Lys Ile Ala Leu Ala Glu Leu Phe Arg Tyr Ile Asn Gly Thr Asp 
            260                 265                 270         


Cys Trp Ser Thr Ile Tyr Leu Glu Asn His Asp Gln Pro Arg Ser Ile 
        275                 280                 285             


Thr Arg Phe Gly Asp Asp Ser Pro Lys Asn Arg Val Ile Ser Gly Lys 
    290                 295                 300                 


Leu Leu Ser Val Leu Leu Ser Ala Leu Thr Gly Thr Leu Tyr Val Tyr 
305                 310                 315                 320 


Gln Gly Gln Glu Leu Gly Gln Ile Asn Phe Lys Asn Trp Pro Val Glu 
                325                 330                 335     


Lys Tyr Glu Asp Val Glu Ile Arg Asn Asn Tyr Asn Ala Ile Lys Glu 
            340                 345                 350         


Glu His Gly Glu Asn Ser Glu Glu Met Lys Lys Phe Leu Glu Gly Ile 
        355                 360                 365             


Ala Leu Val Ser Arg Asp His Ala Arg Thr Pro Met Pro Trp Thr Pro 
    370                 375                 380                 


Asn Glu Pro Asn Ala Gly Phe Ser Gly Pro Asn Thr Lys Pro Trp Phe 
385                 390                 395                 400 


Tyr Leu Asn Glu Ser Phe Arg Gln Gly Ile Asn Val Glu Glu Glu Gln 
                405                 410                 415     


Lys Asn Ser Asp Ser Val Leu Ala Phe Trp Lys Lys Ala Leu Glu Phe 
            420                 425                 430         


Arg Lys Asn His Lys Asp Ile Ala Val Tyr Gly Phe Asp Phe Lys Phe 
        435                 440                 445             


Ile Asp Leu Asp Asn Lys Lys Leu Phe Ser Phe Thr Lys Arg Tyr Asn 
    450                 455                 460                 


Asn Lys Thr Leu Phe Ala Ala Leu Asn Phe Ser Ser Asp Ala Thr Asp 
465                 470                 475                 480 


Phe Lys Ile Pro Asn Asp Gly Ser Ser Phe Lys Leu Glu Phe Gly Asn 
                485                 490                 495     


Tyr Pro Lys Asn Glu Val Asp Ala Ser Ser Arg Thr Leu Lys Pro Trp 
            500                 505                 510         


Glu Gly Arg Ile Tyr Ile Asn Glu 
        515                 520 


<210>  6
<211>  543
<212>  PRT
<213>  Hybrid yeast 1

<400>  6

Met Ser Ala Asp Ala Ser Thr Asn Ser Asn Ala Ser Leu Asp Glu Lys 
1               5                   10                  15      


Asn Leu Asn Ile Thr Ser Glu Ala Glu Ile Lys Asn Glu Asp Val Thr 
            20                  25                  30          


Ala Glu Pro Val Leu Ser Thr Val Leu Ser Pro Asn Gly Lys Ile Val 
        35                  40                  45              


Tyr Ile Ser Asp Lys Val Asp Glu Ala Met Lys Leu Ala Glu Glu Ala 
    50                  55                  60                  


Lys Glu Ile Glu Val Thr Pro Glu Glu Asp Arg Lys Leu Arg Trp Lys 
65                  70                  75                  80  


Ile Asp Tyr Cys Met Phe Pro Leu Met Cys Ile Leu Tyr Ala Val Gln 
                85                  90                  95      


Phe Met Asp Lys Ile Ser Thr Ser Ser Ala Ala Val Met Gly Leu Arg 
            100                 105                 110         


Thr Asp Leu Lys Met His Gly Asp Gln Tyr Ser Trp Val Thr Ser Ala 
        115                 120                 125             


Phe Tyr Phe Gly Tyr Leu Phe Met Asn Leu Gly Pro Val Gln Phe Ile 
    130                 135                 140                 


Phe Gln Arg Thr Ser His Met Ser Lys Met Leu Ala Val Phe Ile Val 
145                 150                 155                 160 


Ile Trp Gly Met Leu Leu Ala Leu His Ala Ala Pro Thr Val Lys Tyr 
                165                 170                 175     


Pro Ser Phe Ile Val Leu Arg Val Leu Leu Gly Cys Ala Glu Ser Val 
            180                 185                 190         


Val Thr Pro Cys Phe Thr Ile Ile Thr Ala Gln Tyr Trp Lys Thr Glu 
        195                 200                 205             


Glu Gln Phe Thr Arg Val Ser Ile Trp Phe Gly Met Asn Gly Leu Gly 
    210                 215                 220                 


Ser Ile Leu Ile Asn Ala Ile Ala Tyr Gly Val Tyr Ile His Gln Asp 
225                 230                 235                 240 


Ser Tyr Ala Ile Lys Gly Trp Arg Thr Leu Phe Val Ile Thr Gly Val 
                245                 250                 255     


Ile Thr Ile Phe Ile Gly Ile Leu Ile Phe Leu Trp Ile Pro Asp Asp 
            260                 265                 270         


Pro Ser Lys Ala Arg Phe Leu Ser Lys Arg Glu Lys Leu Met Val Val 
        275                 280                 285             


Gln Arg Ile Arg Ser Asn Gln Gln Gly Phe Gly Asn His Glu Ile Lys 
    290                 295                 300                 


Lys Tyr Gln Ile Ile Glu Ala Leu Lys Asp Val Arg Thr Trp Leu Tyr 
305                 310                 315                 320 


Phe Leu Phe Thr Val Ser Ser Asn Ile Pro Asn Gly Gly Ile Ser Ser 
                325                 330                 335     


Phe Met Ser Ile Leu Leu Asn Ser Asp Phe Gly Tyr Ser Ser Lys Glu 
            340                 345                 350         


Thr Leu Leu Met Gly Leu Pro Thr Gly Ala Val Glu Leu Val Gly Cys 
        355                 360                 365             


Pro Leu Phe Gly Ile Leu Ala Val Tyr Ala Ala Asn Lys Lys Ile Pro 
    370                 375                 380                 


Phe Trp Lys Tyr Lys Leu Ser Trp Ala Ile Phe Ala Ala Val Leu Ala 
385                 390                 395                 400 


Leu Ile Ala Ser Cys Met Leu Gly Phe Ala Thr Asn Ser Lys Lys Ala 
                405                 410                 415     


Arg Leu Ala Gly Ala Tyr Leu Trp Tyr Ile Ser Pro Val Ser Phe Ile 
            420                 425                 430         


Cys Val Leu Ser Asn Ile Ser Ala Asn Ser Ser Gly Tyr Ser Lys Lys 
        435                 440                 445             


Trp Thr Val Ser Ser Ile Asn Leu Val Ala Tyr Ala Ala Ala Asn Leu 
    450                 455                 460                 


Ala Gly Pro Gln Thr Phe Ile Ala Lys Gln Ala Pro Lys Tyr His Gly 
465                 470                 475                 480 


Ala Lys Val Ala Met Val Val Cys Tyr Ala Val Met Ile Val Leu Leu 
                485                 490                 495     


Ser Ile Leu Leu Ile Val Asn Leu Arg Glu Asn Lys Arg Arg Asp Lys 
            500                 505                 510         


Ile Ala Ala Glu Arg Gly Phe Pro Glu Glu Thr Glu Asn Leu Glu Phe 
        515                 520                 525             


Ser Asp Leu Thr Asp Phe Glu Asn Pro Asn Phe Arg Tyr Thr Leu 
    530                 535                 540             


<210>  7
<211>  601
<212>  PRT
<213>  S. cerevisiae


<220>
<221>  misc_feature
<222>  (426)..(426)
<223>  Xaa can be any naturally occurring amino acid

<400>  7

Met Leu Asn His Pro Ser Gln Gly Ser Asp Asp Ala Gln Asp Glu Lys 
1               5                   10                  15      


Gln Gly Asp Phe Pro Val Ile Glu Glu Glu Lys Thr Gln Ala Val Met 
            20                  25                  30          


Leu Lys Asp Ser Tyr Val Ser Asp Asp Val Ala Asn Ser Thr Glu Arg 
        35                  40                  45              


Tyr Asn Leu Ser Pro Ser Pro Glu Asp Glu Asp Phe Glu Ala Pro Thr 
    50                  55                  60                  


Glu Glu Glu Met Gln Thr Leu Arg His Val Gly Gly Lys Ile Pro Met 
65                  70                  75                  80  


Arg Cys Trp Leu Ile Ala Ile Val Glu Leu Ser Glu Arg Phe Ser Tyr 
                85                  90                  95      


Tyr Gly Leu Ser Ala Pro Phe Gln Asn Tyr Met Glu Tyr Gly Pro Asn 
            100                 105                 110         


Asp Ser Pro Lys Gly Val Leu Ser Leu Asn Ser Gln Gly Ala Thr Gly 
        115                 120                 125             


Leu Ser Tyr Phe Phe Gln Phe Trp Cys Tyr Val Thr Pro Val Phe Gly 
    130                 135                 140                 


Gly Tyr Val Ala Asp Thr Phe Trp Gly Lys Tyr Asn Thr Ile Cys Cys 
145                 150                 155                 160 


Gly Thr Ala Ile Tyr Ile Ala Gly Ile Phe Ile Leu Phe Ile Thr Ser 
                165                 170                 175     


Ile Pro Ser Val Gly Asn Arg Asp Ser Ala Ile Gly Gly Phe Ile Ala 
            180                 185                 190         


Ala Ile Ile Leu Ile Gly Ile Ala Thr Gly Met Ile Lys Ala Asn Leu 
        195                 200                 205             


Ser Val Leu Ile Ala Asp Gln Leu Pro Lys Arg Lys Pro Ser Ile Lys 
    210                 215                 220                 


Val Leu Lys Ser Gly Glu Arg Val Ile Val Asp Ser Asn Ile Thr Leu 
225                 230                 235                 240 


Gln Asn Val Phe Met Phe Phe Tyr Phe Met Ile Asn Val Gly Ser Leu 
                245                 250                 255     


Ser Leu Met Ala Thr Thr Glu Leu Glu Tyr His Lys Gly Phe Trp Ala 
            260                 265                 270         


Ala Tyr Leu Leu Pro Phe Cys Phe Phe Trp Ile Ala Val Val Thr Leu 
        275                 280                 285             


Ile Phe Gly Lys Lys Gln Tyr Ile Gln Arg Pro Ile Gly Asp Lys Val 
    290                 295                 300                 


Ile Ala Lys Ser Phe Lys Val Cys Trp Ile Leu Thr Lys Asn Lys Phe 
305                 310                 315                 320 


Asp Phe Asn Ala Ala Lys Pro Ser Val His Pro Glu Lys Asn Tyr Pro 
                325                 330                 335     


Trp Asn Asp Lys Phe Val Asp Glu Ile Lys Arg Ala Leu Ala Ala Cys 
            340                 345                 350         


Lys Val Phe Ile Phe Tyr Pro Ile Tyr Trp Thr Gln Tyr Gly Thr Met 
        355                 360                 365             


Ile Ser Ser Phe Ile Thr Gln Ala Ser Met Met Glu Leu His Gly Ile 
    370                 375                 380                 


Pro Asn Asp Phe Leu Gln Ala Phe Asp Ser Ile Ala Leu Ile Ile Phe 
385                 390                 395                 400 


Ile Pro Ile Phe Glu Lys Phe Val Tyr Pro Phe Ile Arg Arg Tyr Thr 
                405                 410                 415     


Pro Leu Lys Pro Ile Thr Lys Ile Phe Xaa Gly Phe Met Phe Gly Ser 
            420                 425                 430         


Phe Ala Met Thr Trp Ala Ala Val Leu Gln Ser Phe Val Tyr Lys Ala 
        435                 440                 445             


Gly Pro Trp Tyr Asn Glu Pro Leu Gly His Asn Thr Pro Asn His Val 
    450                 455                 460                 


His Val Cys Trp Gln Ile Pro Ala Tyr Val Leu Ile Ser Phe Ser Glu 
465                 470                 475                 480 


Ile Phe Ala Ser Ile Thr Gly Leu Glu Tyr Ala Tyr Ser Lys Ala Pro 
                485                 490                 495     


Ala Ser Met Lys Ser Phe Ile Met Ser Ile Phe Leu Leu Thr Asn Ala 
            500                 505                 510         


Phe Gly Ser Ala Ile Gly Cys Ala Leu Ser Pro Val Thr Val Asp Pro 
        515                 520                 525             


Lys Phe Thr Trp Leu Phe Thr Gly Leu Ala Val Ala Cys Phe Ile Ser 
    530                 535                 540                 


Gly Cys Leu Phe Trp Leu Cys Phe Arg Lys Tyr Asn Asp Thr Glu Glu 
545                 550                 555                 560 


Glu Met Asn Ala Met Asp Tyr Glu Glu Glu Asn Glu Phe Asp Leu Asn 
                565                 570                 575     


Pro Ile Ser Ala Pro Lys Ala Asn Asp Ile Glu Ile Leu Glu Pro Met 
            580                 585                 590         


Asp Ser Leu Arg Ser Thr Ala Lys Tyr 
        595                 600     


<210>  8
<211>  601
<212>  PRT
<213>  S. pastorianus

<400>  8

Met Leu Asn His Pro Ser Gln Gly Ser Asp Asp Ala Gln Asp Glu Lys 
1               5                   10                  15      


Gln Gly Asp Phe Pro Val Ile Glu Glu Glu Lys Thr Gln Ala Val Thr 
            20                  25                  30          


Leu Lys Asp Ser Tyr Val Ser Asp Asp Val Ala Asn Ser Thr Glu Arg 
        35                  40                  45              


Tyr Asn Leu Ser Pro Ser Pro Glu Asp Glu Asp Phe Glu Ala Pro Thr 
    50                  55                  60                  


Glu Glu Glu Met Gln Thr Leu Arg His Val Gly Gly Lys Ile Pro Met 
65                  70                  75                  80  


Arg Cys Trp Leu Ile Ala Ile Val Glu Leu Ser Glu Arg Phe Ser Tyr 
                85                  90                  95      


Tyr Gly Leu Ser Ala Pro Phe Gln Asn Tyr Met Glu Tyr Gly Pro Asn 
            100                 105                 110         


Asp Ser Pro Lys Gly Val Leu Ser Leu Asn Ser Gln Gly Ala Thr Gly 
        115                 120                 125             


Leu Ser Tyr Phe Phe Gln Phe Trp Cys Tyr Val Thr Pro Val Phe Gly 
    130                 135                 140                 


Gly Tyr Val Ala Asp Thr Phe Trp Gly Lys Tyr Asn Thr Ile Cys Cys 
145                 150                 155                 160 


Gly Thr Ala Ile Tyr Ile Ala Gly Ile Phe Ile Leu Phe Ile Thr Ser 
                165                 170                 175     


Ile Pro Ser Val Gly Asn Arg Asp Ser Ala Ile Gly Gly Phe Ile Ala 
            180                 185                 190         


Ala Ile Ile Leu Ile Gly Ile Ala Thr Gly Met Ile Lys Ala Asn Leu 
        195                 200                 205             


Ser Val Leu Ile Ala Asp Gln Leu Pro Lys Arg Lys Pro Ser Ile Lys 
    210                 215                 220                 


Val Leu Lys Ser Gly Glu Arg Val Ile Val Asp Ser Asn Ile Thr Leu 
225                 230                 235                 240 


Gln Asn Val Phe Met Phe Phe Tyr Phe Met Ile Asn Val Gly Ser Leu 
                245                 250                 255     


Ser Leu Met Ala Thr Thr Glu Leu Glu Tyr His Lys Gly Phe Trp Ala 
            260                 265                 270         


Ala Tyr Leu Leu Pro Phe Cys Phe Phe Trp Ile Ala Val Val Thr Leu 
        275                 280                 285             


Ile Phe Gly Lys Lys Gln Tyr Ile Gln Arg Pro Val Gly Asp Lys Val 
    290                 295                 300                 


Ile Ala Lys Ser Phe Lys Val Cys Trp Ile Leu Thr Lys Asn Lys Phe 
305                 310                 315                 320 


Asp Phe Asn Ala Ala Lys Pro Ser Val His Pro Glu Lys Asn Tyr Pro 
                325                 330                 335     


Trp Asn Asp Lys Phe Val Asp Glu Ile Lys Arg Ala Leu Ala Ala Cys 
            340                 345                 350         


Lys Val Phe Ile Phe Tyr Pro Ile Tyr Trp Thr Gln Tyr Gly Thr Met 
        355                 360                 365             


Ile Ser Ser Phe Ile Thr Gln Ala Ser Met Met Glu Leu His Gly Ile 
    370                 375                 380                 


Pro Asn Asp Phe Leu Gln Ala Phe Asp Ser Ile Ala Leu Ile Ile Phe 
385                 390                 395                 400 


Ile Pro Ile Phe Glu Lys Phe Val Tyr Pro Phe Ile Arg Arg Tyr Thr 
                405                 410                 415     


Pro Leu Lys Pro Ile Thr Lys Ile Phe Phe Gly Phe Met Phe Gly Ser 
            420                 425                 430         


Phe Ala Met Thr Trp Ala Ala Val Leu Gln Ser Phe Val Tyr Lys Ala 
        435                 440                 445             


Gly Pro Trp Tyr Asn Glu Pro Leu Gly His Asn Thr Pro Asn His Val 
    450                 455                 460                 


His Val Cys Trp Gln Ile Pro Ala Tyr Val Leu Ile Ser Phe Ser Glu 
465                 470                 475                 480 


Ile Phe Ala Ser Ile Thr Gly Leu Glu Tyr Ala Tyr Ser Lys Ala Pro 
                485                 490                 495     


Ala Ser Met Lys Ser Phe Ile Met Ser Ile Phe Leu Leu Thr Asn Ala 
            500                 505                 510         


Phe Gly Ser Ala Ile Gly Cys Ala Leu Ser Pro Val Thr Val Asp Pro 
        515                 520                 525             


Lys Phe Thr Trp Leu Phe Thr Gly Leu Ala Val Ala Cys Phe Ile Ser 
    530                 535                 540                 


Gly Cys Leu Phe Trp Leu Cys Phe Arg Lys Tyr Asn Asp Thr Glu Glu 
545                 550                 555                 560 


Glu Met Asn Ala Met Asp Tyr Glu Glu Glu Asp Glu Phe Asp Leu Asn 
                565                 570                 575     


Pro Ile Ser Ala Pro Lys Ala Asn Asp Ile Glu Ile Leu Glu Pro Met 
            580                 585                 590         


Glu Ser Leu Arg Ser Thr Thr Lys Tyr 
        595                 600     


<210>  9
<211>  601
<212>  PRT
<213>  Hybrid yeast 1

<400>  9

Met Leu Asn His Leu Ser Gln Gly Ser Asp Asp Ile Gln Asp Glu Lys 
1               5                   10                  15      


Gln Gly Asp Phe Pro Val Ile Glu Glu Glu Lys Asn Gln Thr Val Thr 
            20                  25                  30          


Leu Lys Asp Ser Tyr Val Ser Asp Asp Ala Ala Asn Ser Thr Glu His 
        35                  40                  45              


Tyr Asn Leu Ser Pro Ser Leu Glu Glu Asp Glu Phe Glu Ala Pro Thr 
    50                  55                  60                  


Asp Glu Glu Leu Arg Ser Leu Arg His Val Gly Gly Lys Ile Pro Met 
65                  70                  75                  80  


Arg Cys Trp Leu Ile Ala Ile Val Glu Leu Ser Glu Arg Phe Ser Tyr 
                85                  90                  95      


Tyr Gly Leu Ser Ala Pro Phe Gln Asn Tyr Met Glu Tyr Gly Pro Lys 
            100                 105                 110         


Asp Thr Pro Lys Gly Val Leu Ser Leu Asn Ser Gln Gly Ala Thr Gly 
        115                 120                 125             


Leu Ser Tyr Phe Phe Gln Phe Trp Cys Tyr Val Thr Pro Val Phe Gly 
    130                 135                 140                 


Gly Tyr Val Ala Asp Thr Phe Trp Gly Lys Tyr Asn Thr Ile Cys Cys 
145                 150                 155                 160 


Gly Thr Ala Ile Tyr Ile Ala Gly Ile Phe Ile Leu Leu Ile Thr Ser 
                165                 170                 175     


Ile Pro Ser Val Gly Asn Arg Asp Ser Ala Leu Gly Gly Phe Ile Ala 
            180                 185                 190         


Ser Ile Ile Leu Ile Gly Ile Ala Thr Gly Met Ile Lys Ala Asn Leu 
        195                 200                 205             


Ser Val Leu Ile Ala Asp Gln Leu Pro Lys Arg Lys Pro Ser Ile Lys 
    210                 215                 220                 


Val Leu Lys Ser Gly Glu Arg Val Ile Val Asp Ser Asn Ile Thr Leu 
225                 230                 235                 240 


Gln Asn Val Phe Met Phe Phe Tyr Phe Met Ile Asn Val Gly Ser Leu 
                245                 250                 255     


Ser Leu Met Ala Thr Thr Glu Leu Glu Tyr His Lys Gly Phe Trp Ala 
            260                 265                 270         


Ala Tyr Leu Leu Pro Phe Cys Phe Phe Trp Val Ala Val Val Thr Leu 
        275                 280                 285             


Val Phe Gly Lys Lys Gln Tyr Ile Gln Arg Pro Ile Gly Asp Lys Val 
    290                 295                 300                 


Ile Ala Lys Ser Phe Arg Val Cys Trp Ile Leu Thr Lys Asn Lys Phe 
305                 310                 315                 320 


Asp Phe Asn Ala Ala Lys Pro Ser Val His Pro Glu Lys Glu Tyr Pro 
                325                 330                 335     


Trp Asn Asp Lys Phe Val Asp Glu Ile Lys Arg Ala Leu Ala Ala Cys 
            340                 345                 350         


Lys Val Phe Val Phe Tyr Pro Ile Tyr Trp Thr Gln Tyr Gly Thr Met 
        355                 360                 365             


Ile Ser Ser Phe Ile Thr Gln Ala Gly Met Met Glu Leu His Gly Ile 
    370                 375                 380                 


Pro Asn Asp Phe Leu Gln Ala Phe Asp Ser Ile Ala Leu Ile Ile Phe 
385                 390                 395                 400 


Ile Pro Ile Phe Glu Lys Phe Ile Tyr Pro Phe Ile Arg Arg Tyr Thr 
                405                 410                 415     


Pro Phe Lys Pro Ile Thr Lys Ile Phe Phe Gly Phe Met Phe Gly Ser 
            420                 425                 430         


Leu Ala Met Thr Trp Ala Ala Val Leu Gln Ser Phe Val Tyr Lys Ala 
        435                 440                 445             


Gly Pro Trp Tyr Ser Ala Pro Leu Gly His Asn Thr Pro Asn His Val 
    450                 455                 460                 


His Val Cys Trp Gln Ile Pro Ala Tyr Val Leu Ile Ser Phe Ser Glu 
465                 470                 475                 480 


Ile Phe Ala Ser Ile Thr Gly Leu Glu Tyr Ala Tyr Ser Lys Ala Pro 
                485                 490                 495     


Ala Ser Met Lys Ser Phe Ile Met Ser Ile Phe Leu Leu Thr Asn Ala 
            500                 505                 510         


Phe Gly Ser Ala Ile Gly Cys Ala Leu Ser Pro Val Thr Val Asp Pro 
        515                 520                 525             


Lys Phe Thr Trp Leu Phe Thr Gly Leu Ala Val Ala Cys Phe Ile Ser 
    530                 535                 540                 


Gly Cys Leu Phe Trp Phe Cys Phe Arg Lys Tyr Asn Asp Thr Glu Glu 
545                 550                 555                 560 


Glu Met Asn Ala Met Asp Tyr Glu Glu Glu Asp Glu Phe Asp Leu Asn 
                565                 570                 575     


Pro Ile Ser Gln Pro Lys Gly Asn Asp Ile Glu Ile Leu Glu Pro Met 
            580                 585                 590         


Gly Ser Leu Lys Ser Thr Thr Lys Tyr 
        595                 600     


<210>  10
<211>  399
<212>  PRT
<213>  Hybrid yeast 1

<400>  10

Phe Lys Glu Phe Cys Lys Val Glu Gly Gly Val Leu Ile Trp Gln Arg 
1               5                   10                  15      


Val Gln Lys Ser Asn Leu Thr Lys Ser Tyr Ser Ile Ser Phe Lys Gln 
            20                  25                  30          


Gly Leu Tyr Thr Val Glu Thr Leu Leu Ser Lys Val His Asp Pro Asn 
        35                  40                  45              


Ile Pro Leu Arg Pro Lys Glu Ile Ile Ser Leu Leu Thr Leu Cys Lys 
    50                  55                  60                  


Leu Phe Asn Gly Ala Trp Lys Ile Lys Arg Lys Glu Gly Glu His Val 
65                  70                  75                  80  


Leu His Glu Asp Gln Asn Phe Ile Ser Tyr Leu Glu Tyr Thr Thr Ser 
                85                  90                  95      


Ile Tyr Ser Ile Ile Gln Thr Ala Glu Lys Val Ser Glu Lys Ser Lys 
            100                 105                 110         


Asp Ser Ile Asp Ser Lys Leu Phe Leu Asn Ala Ile Arg Ile Ile Ser 
        115                 120                 125             


Ser Phe Leu Gly Asn Arg Ser Leu Thr Tyr Lys Leu Ile Tyr Asp Ser 
    130                 135                 140                 


His Glu Val Ile Lys Phe Ser Val Ser His Glu Arg Val Ala Phe Met 
145                 150                 155                 160 


Asn Pro Leu Gln Thr Met Leu Ser Phe Leu Ile Glu Lys Val Ser Leu 
                165                 170                 175     


Lys Asp Ala Tyr Glu Ala Leu Glu Asp Cys Ser Asp Phe Leu Lys Ile 
            180                 185                 190         


Ser Asp Phe Ser Leu Arg Ser Val Val Leu Cys Ser Gln Ile Asp Val 
        195                 200                 205             


Gly Phe Trp Val Arg Asn Gly Met Ser Val Leu His Gln Ala Ser Tyr 
    210                 215                 220                 


Tyr Lys Asn Asn Pro Glu Leu Gly Ser Tyr Ser Arg Asp Ile His Leu 
225                 230                 235                 240 


Asn Gln Leu Ala Ile Leu Trp Glu Arg Asp Asp Ile Pro Arg Ile Ile 
                245                 250                 255     


Tyr Asn Ile Leu Asp Arg Trp Glu Leu Leu Asp Trp Phe Thr Gly Glu 
            260                 265                 270         


Val Asp Tyr Gln His Thr Val Tyr Glu Asp Lys Ile Ser Phe Ile Ile 
        275                 280                 285             


Gln Gln Phe Ile Ala Phe Ile Tyr Gln Ile Leu Thr Glu Arg Gln Tyr 
    290                 295                 300                 


Phe Lys Thr Phe Ser Ser Leu Lys Asp Arg Arg Met Asp Gln Ile Lys 
305                 310                 315                 320 


Asn Ser Ile Ile Tyr Asn Leu Tyr Met Lys Pro Leu Ser Tyr Ser Lys 
                325                 330                 335     


Leu Leu Arg Ser Val Pro Asp Tyr Leu Thr Glu Asp Thr Thr Glu Phe 
            340                 345                 350         


Asp Glu Ala Leu Glu Glu Val Ser Val Phe Val Glu Pro Lys Gly Leu 
        355                 360                 365             


Ala Asp Asn Gly Val Phe Lys Leu Lys Ala Ser Leu Tyr Ala Lys Val 
    370                 375                 380                 


Asp Pro Leu Lys Leu Leu Asn Leu Glu Asn Glu Phe Glu Ser Ser 
385                 390                 395                 


<210>  11
<211>  1950
<212>  PRT
<213>  Hybrid yeast 1

<400>  11

Met Ser Phe Thr Asp Asn Gly Leu Gly Ser Leu Lys Ala His Ile Arg 
1               5                   10                  15      


Arg Thr Leu Arg Ser Ile His Asn Leu Pro Tyr Phe Arg Phe Thr Arg 
            20                  25                  30          


Gly Pro Thr Glu Arg Ala Asp Met Ser Arg Ala Leu Lys Glu Phe Ile 
        35                  40                  45              


Tyr Arg Tyr Leu Tyr Phe Ile Ile Ser Asn Asp Gly Glu Asn Leu Ser 
    50                  55                  60                  


Thr Leu Phe Thr Ala His Pro Lys Gln Lys Ser Ser Asn Gln Glu Leu 
65                  70                  75                  80  


Ala Val Phe Pro Glu Ser Leu Glu Asp Ala Leu Asp Val Asp Lys Ile 
                85                  90                  95      


Thr Ser Gln Gly Thr Phe Pro Phe Tyr Lys Ile Asp Glu Ser Lys Ile 
            100                 105                 110         


Gly Asp Val His Lys His Thr Gly Arg Asn Cys Gly Arg Lys Phe Lys 
        115                 120                 125             


Ile Gly Glu Pro Leu Tyr Arg Cys His Glu Cys Gly Cys Asp Asp Thr 
    130                 135                 140                 


Cys Val Leu Cys Ile His Cys Phe Asn Pro Lys Asp His Val Asn His 
145                 150                 155                 160 


His Val Cys Thr Asp Ile Cys Ser Glu Phe Thr Ser Gly Ile Cys Asp 
                165                 170                 175     


Cys Gly Asp Glu Glu Ala Trp Asn Ser Ser Leu His Cys Lys Ala Glu 
            180                 185                 190         


Glu Gln Gly Asn Asp Thr Ser Glu Asp Pro Ser Asn Phe Asp Ser Thr 
        195                 200                 205             


Lys Gln Lys Asp Val Trp Asn Asp Pro Glu Cys Ile Ala Leu Val Glu 
    210                 215                 220                 


Leu Val Leu Ser Glu Val Phe Asp Tyr Phe Ile Asp Val Phe Asn Gln 
225                 230                 235                 240 


Asn Ile Glu Pro Leu Pro Thr Ile Gln Lys Asp Ile Thr Ile Lys Leu 
                245                 250                 255     


Arg Glu Met Thr Gln Gln Gly Lys Met Tyr Glu Arg Ala Gln Phe Leu 
            260                 265                 270         


Asn Asp Leu Lys Tyr Glu Asn Asp Tyr Met Phe Asp Gly Thr Thr Thr 
        275                 280                 285             


Ala Lys Thr Ser Pro Ser Asn Ser Pro Glu Ala Ser Pro Ser Leu Ala 
    290                 295                 300                 


Lys Ile Asp Pro Glu Asn Tyr Thr Val Ile Ile Tyr Asn Asp Glu Tyr 
305                 310                 315                 320 


His Asn Tyr Ser Gln Ala Thr Thr Ala Leu Arg Gln Gly Val Pro Asp 
                325                 330                 335     


Asn Val His Ile Asp Leu Leu Thr Ser Arg Ile Asp Gly Glu Gly Arg 
            340                 345                 350         


Ala Met Leu Lys Cys Ser Gln Asp Leu Ser Ser Val Leu Gly Gly Phe 
        355                 360                 365             


Phe Ala Val Gln Thr Asn Gly Leu Ser Ala Thr Leu Thr Ser Trp Ser 
    370                 375                 380                 


Glu Tyr Leu His Gln Glu Ala Cys Lys Tyr Ile Ile Leu Trp Ile Thr 
385                 390                 395                 400 


His Cys Leu Asn Ile Pro Asn Pro Ser Phe Gln Ile Thr Phe Arg Asn 
                405                 410                 415     


Met Met Gly Lys Ser Leu Cys Ser Glu Tyr Leu Asn Ala Thr Glu Ser 
            420                 425                 430         


Arg Asp Met Thr Pro Val Val Glu Lys Tyr Phe Ser Thr Lys Phe Asp 
        435                 440                 445             


Lys Asp Asp Pro Tyr Arg Tyr Ile Asp Leu Ser Val Leu Ala Glu Gly 
    450                 455                 460                 


Asn Gln Ile Pro Leu Gly His His Lys Val Leu Pro Glu Ser Ser Thr 
465                 470                 475                 480 


His Ser Leu Ser Thr Leu Ile Asn Asp Val Glu Asn Leu Thr Ser Lys 
                485                 490                 495     


Glu Tyr Ser Asn Thr Arg Leu Gln His Ile Leu Tyr Phe Asp Asn Arg 
            500                 505                 510         


Tyr Trp Lys Arg Leu Arg Lys Asp Ile Gln Asn Val Ile Ile Pro Thr 
        515                 520                 525             


Leu Ala Ser Ser Thr Leu Tyr Lys Pro Ile Phe Cys Gln Gln Val Val 
    530                 535                 540                 


Glu Ile Phe Asn His Ile Thr Arg Ser Val Ala Tyr Met Asp Arg Glu 
545                 550                 555                 560 


Pro Gln Leu Thr Ala Ile Arg Glu Cys Val Val Gln Leu Phe Thr Cys 
                565                 570                 575     


Pro Thr Asn Thr Arg Asn Ile Phe Glu Asn Gln Ser Phe Leu Asp Ile 
            580                 585                 590         


Leu Trp Ser Ile Ile Asp Ile Phe Lys Glu Phe Cys Lys Val Glu Ala 
        595                 600                 605             


Gly Val Leu Ile Trp Gln Arg Val Gln Lys Ser Asn Leu Thr Lys Ser 
    610                 615                 620                 


Tyr Ser Leu Ser Phe Lys Gln Gly Leu Tyr Thr Val Glu Thr Leu Leu 
625                 630                 635                 640 


Ser Lys Val Asn Asp Pro Asn Ile Thr Ile Arg Pro Lys Val Phe Ile 
                645                 650                 655     


Ser Leu Leu Thr Leu Gly Lys Leu Phe Asn Gly Ala Trp Lys Ile Lys 
            660                 665                 670         


Arg Lys Glu Gly Glu His Val Leu His Glu Asp Gln Asn Phe Ile Ser 
        675                 680                 685             


Tyr Leu Glu Tyr Thr Thr Ser Ile Tyr Ser Ile Ile Gln Thr Ala Glu 
    690                 695                 700                 


Lys Val Leu Glu Lys Ser His Asp Ser Leu Asp Leu Asn Leu Val Leu 
705                 710                 715                 720 


Asn Ala Ile Arg Ile Val Ser Ser Phe Leu Gly Asn Arg Ser Leu Thr 
                725                 730                 735     


Tyr Lys Leu Ile Tyr Asp Ser His Glu Ile Ile Lys Phe Ser Val Ser 
            740                 745                 750         


His Glu Arg Val Ala Phe Met Asn Pro Ile Gln Thr Met Leu Ser Phe 
        755                 760                 765             


Leu Ile Glu Lys Val Ser Leu Lys Asp Ala Tyr Glu Ser Leu Glu Asn 
    770                 775                 780                 


Cys Pro Asp Phe Leu Lys Ile Ala Asp Phe Ser Leu Arg Ser Val Val 
785                 790                 795                 800 


Leu Cys Ser Gln Ile Asp Val Gly Phe Trp Val Arg Asn Gly Met Ser 
                805                 810                 815     


Val Leu His Gln Ala Ser Tyr Tyr Lys Asn Asn Pro Glu Leu Gly Ser 
            820                 825                 830         


Tyr Ser Arg Asp Ile His Leu Asn Gln Leu Ala Ile Ile Trp Glu Arg 
        835                 840                 845             


Asp Asp Leu Pro Arg Val Ile Tyr Asn Ile Leu Asp Arg Trp Glu Leu 
    850                 855                 860                 


Leu Asp Trp Phe Met Gly Glu Ala Glu Tyr Gln His Thr Val Tyr Glu 
865                 870                 875                 880 


Asp Lys Ile Ser Phe Met Ile Gln Gln Phe Ile Ala Phe Ile Tyr Gln 
                885                 890                 895     


Ile Leu Thr Glu Arg Gln Tyr Phe Lys Thr Phe Ser Leu Leu Arg Asp 
            900                 905                 910         


Arg Arg Met Asp Met Ile Lys Asn Ser Ile Met Tyr Asn Leu Tyr Met 
        915                 920                 925             


Lys Pro Leu Ser Tyr Ser Lys Leu Leu Lys Ser Val Pro Asp Tyr Leu 
    930                 935                 940                 


Thr Asp Asp Thr Thr Glu Phe Asp Glu Ala Leu Glu Glu Val Ser Val 
945                 950                 955                 960 


Phe Val Glu Pro Lys Gly Leu Ala Asp Asn Gly Val Phe Lys Leu Lys 
                965                 970                 975     


Ala Ala Leu Tyr Ala Lys Ile Asp Pro Leu Lys Leu Leu Asn Leu Glu 
            980                 985                 990         


Asn Glu Phe Glu Ser Ser Ala Thr  Ile Ile Lys Thr His  Leu Ala Lys 
        995                 1000                 1005             


Asn Lys  Asp Glu Val Ser Lys  Val Val Leu Ile Pro  Gln Val Ser 
    1010                 1015                 1020             


Thr Lys  Leu Leu Asp Lys Gly  Ala Met Asn Leu Gly  Glu Phe Thr 
    1025                 1030                 1035             


Arg Asn  Thr Val Phe Ala Lys  Val Ile Tyr Lys Leu  Leu Gln Val 
    1040                 1045                 1050             


Cys Leu  Asp Met Glu Asp Ser  Thr Phe Leu Asn Glu  Leu Leu His 
    1055                 1060                 1065             


Leu Val  His Gly Ile Phe Lys  Asp Asp Glu Leu Ile  Asn Gly Lys 
    1070                 1075                 1080             


Asp Ser  Ile Pro Glu Ala Tyr  Leu Ala Lys Pro Ile  Cys Asn Leu 
    1085                 1090                 1095             


Leu Leu  Ser Ile Ala Asn Ala  Lys Ser Asp Ile Phe  Ser Glu Ser 
    1100                 1105                 1110             


Ile Val  Arg Lys Ala Asp Tyr  Leu Leu Glu Lys Met  Ile Met Lys 
    1115                 1120                 1125             


Lys Pro  Asp Glu Ile Phe Glu  Ser Leu Ile Ala Ser  Phe Gly Asn 
    1130                 1135                 1140             


Gln Tyr  Ile Asp Asn Tyr Lys  Asp Lys Lys Leu Ser  Gln Gly Val 
    1145                 1150                 1155             


Asn Leu  Gln Glu Thr Glu Lys  Glu Arg Lys Arg Arg  Met Ala Lys 
    1160                 1165                 1170             


Lys His  Gln Ala Arg Leu Leu  Ala Lys Phe Asn Asn  Gln Gln Ser 
    1175                 1180                 1185             


Lys Phe  Met Lys Glu His Glu  Ser Glu Phe Asp Glu  Gln Asp Asn 
    1190                 1195                 1200             


Asp Val  Asp Met Asp Gly Glu  Lys Val Tyr Glu Ser  Glu Asp Phe 
    1205                 1210                 1215             


Thr Cys  Ala Leu Cys Gln Asp  Ser Ser Ser Thr Asp  Phe Phe Val 
    1220                 1225                 1230             


Ile Pro  Ala Tyr His Asp His  Thr Pro Ile Phe Arg  Pro Gly Asn 
    1235                 1240                 1245             


Ile Phe  Asn Pro Arg Glu Phe  Met Ala Lys Trp Asp  Gly Phe Tyr 
    1250                 1255                 1260             


Asn Asp  Asp Asp Lys Gln Ala  Tyr Ile Asp Asp Glu  Val Leu Glu 
    1265                 1270                 1275             


Ser Leu  Lys Glu Asn Gly Thr  Arg Gly Ser Arg Lys  Val Phe Val 
    1280                 1285                 1290             


Ser Cys  Asn His His Ile His  His Asn Cys Phe Lys  Arg Tyr Val 
    1295                 1300                 1305             


Gln Lys  Lys Arg Phe Ser Ser  Asn Ala Phe Ile Cys  Pro Leu Cys 
    1310                 1315                 1320             


Gln Thr  Phe Ser Asn Cys Thr  Leu Pro Ile Cys Pro  Thr Ser Arg 
    1325                 1330                 1335             


Ala Asn  Thr Gly Leu Ser Leu  Asp Met Phe Leu Lys  Ser Glu Leu 
    1340                 1345                 1350             


Ser Leu  Asp Ile Leu Ser Arg  Leu Phe Lys Pro Phe  Thr Glu Asp 
    1355                 1360                 1365             


Asn Tyr  Arg Thr Ile Asn Ser  Ile Phe Ser Leu Met  Val Ser Gln 
    1370                 1375                 1380             


Cys Gln  Gly Phe Asp Lys Val  Val Arg Lys His Val  Asn Phe Thr 
    1385                 1390                 1395             


His Lys  Asp Val Ser Leu Val  Leu Ser Val His Trp  Ala Asn Thr 
    1400                 1405                 1410             


Ile Ser  Met Leu Glu Val Ala  Ser Arg Leu Glu Lys  Pro His Asn 
    1415                 1420                 1425             


Ile Ser  Phe Phe Arg Ser Arg  Glu Gln Lys Tyr Lys  Thr Leu Lys 
    1430                 1435                 1440             


Asn Ile  Leu Ile Cys Ile Met  Leu Phe Thr Phe Val  Ile Gly Lys 
    1445                 1450                 1455             


Pro Ser  Met Glu Phe Glu Pro  Tyr Pro Val Glu Ser  Asp Ile Ile 
    1460                 1465                 1470             


Cys Asn  Gln Asn Gln Leu Phe  Gln Tyr Ile Val Arg  Lys Ser Leu 
    1475                 1480                 1485             


Phe Ser  Pro Ala Ser Leu Arg  Glu Thr Ile Thr Glu  Ala Leu Thr 
    1490                 1495                 1500             


Val Phe  Cys Lys Gln Phe Leu  Asp Asp Phe Val Gln  Gly Leu Ser 
    1505                 1510                 1515             


Asp Ala  Glu Gln Val Asp Lys  Leu Tyr Thr Glu Ala  Lys Lys Leu 
    1520                 1525                 1530             


Gly Asp  Val Tyr Asn Val Asp  Glu Ser Ile Leu Ile  Thr Leu Met 
    1535                 1540                 1545             


Ser Ile  Thr Val Val Lys Thr  Glu Gly Leu Glu Ser  Arg Ser Ile 
    1550                 1555                 1560             


Tyr Asp  Leu Ala Tyr Thr Ser  Leu Leu Lys Ser Leu  Leu Pro Thr 
    1565                 1570                 1575             


Ile Arg  Arg Cys Leu Val Met  Val Lys Val Leu His  Glu Leu Val 
    1580                 1585                 1590             


Lys Asp  Ser Glu Asn Glu Thr  Met Val Ile Asp Gly  Phe Asp Val 
    1595                 1600                 1605             


Glu Glu  Glu Leu Glu Phe Glu  Gly Leu Pro Gly Phe  Val Asp Lys 
    1610                 1615                 1620             


Ala Leu  Lys Leu Ile Thr Asp  Lys Glu Ser Phe Val  Asp Leu Phe 
    1625                 1630                 1635             


Lys Thr  Lys Gln Ala Ile Val  Pro Ser His Pro Tyr  Leu Glu Arg 
    1640                 1645                 1650             


Ile Pro  Tyr Glu Tyr Cys Gly  Ile Val Lys Leu Ile  Asp Leu Ser 
    1655                 1660                 1665             


Lys Phe  Leu Asn Thr Tyr Val  Thr Gln Ser Lys Glu  Ile Lys Leu 
    1670                 1675                 1680             


Arg Glu  Glu Arg Ser Gln His  Met Lys Asn Ala Asp  Asn Arg Leu 
    1685                 1690                 1695             


Asp Phe  Lys Ile Cys Leu Thr  Cys Gly Val Lys Val  His Leu Arg 
    1700                 1705                 1710             


Ala Asp  Arg His Glu Met Thr  Lys His Leu Asn Lys  Asn Cys Phe 
    1715                 1720                 1725             


Lys Ser  Phe Gly Ala Phe Leu  Met Pro Asn Ser Ser  Glu Val Cys 
    1730                 1735                 1740             


Leu His  Leu Thr Gln Pro Pro  Ser Asn Ile Phe Val  Ser Ala Pro 
    1745                 1750                 1755             


Tyr Leu  Asn Ser His Gly Glu  Val Gly Arg Asn Ala  Met Arg Arg 
    1760                 1765                 1770             


Gly Asp  Leu Thr Thr Leu Asn  Leu Lys Arg Tyr Glu  His Leu Asn 
    1775                 1780                 1785             


Arg Leu  Trp Ile Asn Asn Glu  Ile Pro Gly Tyr Ile  Ser Arg Val 
    1790                 1795                 1800             


Met Gly  Asp Glu Phe Arg Val  Thr Ile Leu Ser Asn  Gly Phe Leu 
    1805                 1810                 1815             


Phe Ala  Phe Asn Arg Glu Pro  Arg Pro Arg Arg Val  Pro Pro Thr 
    1820                 1825                 1830             


Asp Glu  Asp Asp Glu Asp Met  Glu Glu Gly Glu Glu  Gly Phe Phe 
    1835                 1840                 1845             


Thr Glu  Glu Asn Asp Asp Met  Asp Val Asp Asp Glu  Thr Gly Gln 
    1850                 1855                 1860             


Ala Ala  Asn Leu Phe Gly Val  Gly Ala Glu Gly Ile  Gly Asp Gly 
    1865                 1870                 1875             


Gly Val  Arg Asn Phe Phe Gln  Phe Phe Glu Asn Phe  Arg Asn Thr 
    1880                 1885                 1890             


Leu Gln  Pro Gln Gly Asn Asp  Asp Glu Asp Ala Pro  Gln Asn Pro 
    1895                 1900                 1905             


Pro Pro  Ile Leu Gln Phe Leu  Gly Pro Gln Phe Asp  Gly Ala Thr 
    1910                 1915                 1920             


Ile Ile  Arg Asn Thr Asn Gln  Arg Asn Leu Asp Glu  Asp Asp Ser 
    1925                 1930                 1935             


Ser Glu  Asn Asp Asp Ser Asp  Glu Arg Glu Ile Trp  
    1940                 1945                 1950 


<210>  12
<211>  520
<212>  PRT
<213>  Hybrid yeast 1

<400>  12

Met Gly Tyr Asp Ile Ala Asn Tyr Glu Lys Val Trp Pro Thr Tyr Gly 
1               5                   10                  15      


Thr Asn Glu Asp Cys Phe Ala Leu Ile Glu Lys Thr His Lys Leu Gly 
            20                  25                  30          


Met Lys Phe Ile Thr Asp Leu Val Ile Asn His Cys Ser Ser Glu His 
        35                  40                  45              


Glu Trp Phe Lys Glu Ser Arg Ser Ser Lys Thr Asn Pro Lys Arg Asp 
    50                  55                  60                  


Trp Phe Phe Trp Arg Pro Pro Lys Gly Tyr Asp Ala Glu Gly Lys Pro 
65                  70                  75                  80  


Ile Pro Pro Asn Asn Trp Lys Ser Tyr Phe Gly Gly Ser Ala Trp Thr 
                85                  90                  95      


Phe Asp Glu Lys Thr Gln Glu Phe Tyr Leu Arg Leu Phe Cys Ser Thr 
            100                 105                 110         


Gln Pro Asp Leu Asn Trp Glu Asn Glu Asp Cys Arg Lys Ala Ile Tyr 
        115                 120                 125             


Glu Ser Ala Val Gly Tyr Trp Leu Asp His Gly Val Asp Gly Phe Arg 
    130                 135                 140                 


Ile Asp Val Gly Ser Leu Tyr Ser Lys Val Val Gly Leu Pro Asp Ala 
145                 150                 155                 160 


Pro Val Val Asp Lys Asn Ser Thr Trp Gln Ser Ser Asp Pro Tyr Thr 
                165                 170                 175     


Leu Asn Gly Pro Arg Ile His Glu Phe His Gln Glu Met Asn Gln Phe 
            180                 185                 190         


Ile Arg Asn Arg Val Lys Asp Gly Arg Glu Ile Met Thr Val Gly Glu 
        195                 200                 205             


Met Gln His Ala Ser Asp Glu Thr Lys Arg Leu Tyr Thr Ser Ala Ser 
    210                 215                 220                 


Arg His Glu Leu Ser Glu Leu Phe Asn Phe Ser His Thr Asp Val Gly 
225                 230                 235                 240 


Thr Ser Pro Leu Phe Arg Tyr Asn Leu Val Pro Phe Glu Leu Lys Asp 
                245                 250                 255     


Trp Lys Ile Ala Leu Ala Glu Leu Phe Arg Phe Ile Asn Gly Thr Asp 
            260                 265                 270         


Cys Trp Ser Thr Ile Tyr Leu Glu Asn His Asp Gln Pro Arg Ser Ile 
        275                 280                 285             


Thr Arg Phe Gly Asp Asp Ser Pro Lys Asn Arg Val Ile Ser Gly Lys 
    290                 295                 300                 


Leu Leu Ser Val Leu Leu Ser Ala Leu Thr Gly Thr Leu Tyr Val Tyr 
305                 310                 315                 320 


Gln Gly Gln Glu Leu Gly Gln Ile Asn Phe Lys Asn Trp Ser Val Glu 
                325                 330                 335     


Lys Tyr Glu Asp Val Glu Ile Arg Asn Asn Tyr Arg Leu Ile Lys Glu 
            340                 345                 350         


Glu Cys Gly Glu Asn Ser Glu Glu Met Lys Lys Phe Leu Glu Gly Ile 
        355                 360                 365             


Ala Leu Val Ser Arg Asp His Ala Arg Thr Pro Met Pro Trp Thr Pro 
    370                 375                 380                 


Asn Glu Pro Asn Ala Gly Phe Ser Gly Pro Asn Thr Lys Pro Trp Phe 
385                 390                 395                 400 


Tyr Leu Asn Glu Ser Phe Arg Gln Gly Ile Asn Val Glu Glu Glu Gln 
                405                 410                 415     


Lys Asn Ser Asp Ser Val Leu Ala Phe Trp Lys Lys Ala Leu Glu Phe 
            420                 425                 430         


Arg Lys Asn His Lys Asp Ile Ala Val Tyr Gly Phe Asp Phe Lys Phe 
        435                 440                 445             


Ile Asp Leu Asp Asn Lys Lys Leu Phe Ser Phe Thr Lys Arg Tyr Asn 
    450                 455                 460                 


Asn Lys Thr Leu Phe Ala Ala Leu Asn Phe Ser Ser Asp Ala Thr Asp 
465                 470                 475                 480 


Phe Lys Ile Pro Asn Asp Gly Ser Ser Phe Lys Leu Glu Phe Gly Asn 
                485                 490                 495     


Tyr Pro Lys Asn Glu Val Asp Ala Ser Ser Arg Thr Leu Lys Pro Trp 
            500                 505                 510         


Glu Gly Arg Ile His Ile Asn Glu 
        515                 520 


<210>  13
<211>  520
<212>  PRT
<213>  Hybrid yeast 1

<400>  13

Met Gly Tyr Asp Ile Ala Asn Tyr Glu Lys Val Trp Pro Thr Tyr Gly 
1               5                   10                  15      


Thr Asn Glu Asp Cys Phe Ala Leu Ile Glu Lys Thr His Lys Leu Gly 
            20                  25                  30          


Met Lys Phe Ile Thr Asp Leu Val Ile Asn His Cys Ser Ser Glu His 
        35                  40                  45              


Glu Trp Phe Lys Glu Ser Arg Ser Ser Lys Thr Asn Pro Lys Arg Asp 
    50                  55                  60                  


Trp Phe Phe Trp Arg Pro Pro Lys Gly Tyr Asp Ala Glu Gly Lys Pro 
65                  70                  75                  80  


Ile Pro Pro Asn Asn Trp Lys Ser Tyr Phe Gly Gly Ser Ala Trp Thr 
                85                  90                  95      


Phe Asp Glu Lys Thr Gln Glu Phe Tyr Leu Arg Leu Phe Cys Ser Thr 
            100                 105                 110         


Gln Pro Asp Leu Asn Trp Glu Asn Glu Asp Cys Arg Lys Ala Ile Tyr 
        115                 120                 125             


Glu Ser Ala Val Gly Tyr Trp Leu Asp His Gly Val Asp Gly Phe Arg 
    130                 135                 140                 


Ile Asp Val Gly Ser Leu Tyr Ser Lys Val Val Gly Leu Pro Asp Ala 
145                 150                 155                 160 


Pro Val Val Asp Lys Asn Ser Thr Trp Gln Ser Ser Asp Pro Tyr Thr 
                165                 170                 175     


Leu Asn Gly Pro Arg Ile His Glu Phe His Gln Glu Met Asn Gln Phe 
            180                 185                 190         


Ile Arg Asn Arg Val Lys Gly Gly Arg Glu Ile Met Thr Val Gly Glu 
        195                 200                 205             


Met Gln His Ala Ser Asp Glu Thr Lys Arg Leu Tyr Thr Ser Ala Ser 
    210                 215                 220                 


Arg His Glu Leu Ser Glu Leu Phe Asn Phe Ser His Thr Asp Val Gly 
225                 230                 235                 240 


Thr Ser Pro Leu Phe Arg Tyr Asn Leu Val Pro Phe Glu Leu Lys Asp 
                245                 250                 255     


Trp Lys Ile Ala Leu Ala Glu Leu Phe Arg Phe Ile Asn Gly Thr Asp 
            260                 265                 270         


Cys Trp Ser Thr Ile Tyr Leu Glu Asn His Asp Gln Pro Arg Ser Ile 
        275                 280                 285             


Thr Arg Phe Gly Asp Asp Ser Pro Lys Asn Arg Val Ile Ser Gly Lys 
    290                 295                 300                 


Leu Leu Ser Val Leu Leu Ser Ala Leu Thr Gly Thr Leu Tyr Val Tyr 
305                 310                 315                 320 


Gln Gly Gln Glu Leu Gly Gln Ile Asn Phe Lys Asn Trp Ser Val Glu 
                325                 330                 335     


Lys Tyr Glu Asp Val Glu Ile Arg Asn Asn Tyr Arg Leu Ile Lys Glu 
            340                 345                 350         


Glu Cys Gly Glu Asn Ser Glu Glu Met Lys Lys Phe Leu Glu Gly Ile 
        355                 360                 365             


Ala Leu Val Ser Arg Asp His Ala Arg Thr Pro Met Pro Trp Thr Pro 
    370                 375                 380                 


Asn Glu Pro Asn Ala Gly Phe Ser Gly Pro Asn Thr Lys Pro Trp Phe 
385                 390                 395                 400 


Tyr Leu Asn Glu Ser Phe Arg Gln Gly Ile Asn Val Glu Glu Glu Gln 
                405                 410                 415     


Lys Asn Ser Asp Ser Val Leu Ala Phe Trp Lys Lys Ala Leu Glu Phe 
            420                 425                 430         


Arg Lys Asn His Lys Asp Ile Ala Val Tyr Gly Phe Asp Phe Lys Phe 
        435                 440                 445             


Ile Asp Leu Asp Asn Lys Lys Leu Phe Ser Phe Thr Lys Arg Tyr Asn 
    450                 455                 460                 


Asn Lys Thr Leu Phe Ala Ala Leu Asn Phe Ser Ser Asp Ala Thr Asp 
465                 470                 475                 480 


Phe Lys Ile Pro Asn Asp Gly Ser Ser Phe Lys Leu Glu Phe Gly Asn 
                485                 490                 495     


Tyr Pro Lys Asn Glu Val Asp Ala Ser Ser Arg Thr Leu Lys Pro Trp 
            500                 505                 510         


Glu Gly Arg Ile His Ile Asn Glu 
        515                 520 


<210>  14
<211>  589
<212>  PRT
<213>  Hybrid yeast 1

<400>  14

Met Thr Ile Ser Ser Ala His Pro Glu Thr Glu Pro Lys Trp Trp Lys 
1               5                   10                  15      


Glu Ala Thr Phe Tyr Gln Ile Tyr Pro Ala Ser Phe Lys Asp Ser Asn 
            20                  25                  30          


Asp Asp Gly Trp Gly Asp Met Lys Gly Ile Ser Ser Lys Leu Glu Tyr 
        35                  40                  45              


Ile Lys Glu Leu Gly Val Asp Ala Ile Trp Ile Ser Pro Leu Tyr Asp 
    50                  55                  60                  


Ser Pro Gln Asp Asp Met Gly Tyr Asp Ile Ala Asn Tyr Glu Lys Val 
65                  70                  75                  80  


Trp Pro Thr Tyr Gly Thr Asn Glu Asp Cys Phe Ala Leu Ile Glu Lys 
                85                  90                  95      


Thr His Lys Leu Gly Met Lys Phe Ile Thr Asp Leu Val Ile Asn His 
            100                 105                 110         


Cys Ser Ser Glu His Glu Trp Phe Lys Glu Ser Arg Ser Ser Lys Thr 
        115                 120                 125             


Asn Pro Lys Arg Asp Trp Ser Phe Trp Arg Pro Pro Lys Gly Tyr Asp 
    130                 135                 140                 


Ala Glu Gly Lys Pro Ile Pro Pro Asn Asn Trp Lys Ser Tyr Phe Gly 
145                 150                 155                 160 


Gly Ser Ala Trp Thr Phe Asp Glu Lys Thr Gln Glu Phe Tyr Leu Arg 
                165                 170                 175     


Leu Phe Cys Ser Thr Gln Pro Asp Leu Asn Trp Glu Asn Glu Asp Cys 
            180                 185                 190         


Arg Lys Ala Ile Tyr Glu Ser Ala Val Gly Tyr Trp Leu Asp His Gly 
        195                 200                 205             


Val Asp Gly Phe Arg Ile Asp Val Gly Ser Leu Tyr Ser Lys Val Val 
    210                 215                 220                 


Gly Leu Pro Asp Ala Pro Val Val Asp Lys Asn Ser Thr Trp Gln Ser 
225                 230                 235                 240 


Ser Asp Pro Tyr Thr Leu Asn Gly Pro Arg Ile His Glu Phe His Gln 
                245                 250                 255     


Glu Met Asn Gln Phe Ile Arg Asn Arg Val Lys Asp Gly Arg Glu Ile 
            260                 265                 270         


Met Thr Val Gly Glu Met Gln His Ala Ser Asp Glu Thr Lys Arg Leu 
        275                 280                 285             


Tyr Thr Ser Ala Ser Arg His Glu Leu Ser Glu Leu Phe Asn Phe Ser 
    290                 295                 300                 


His Thr Asp Val Gly Thr Ser Pro Leu Phe Arg Tyr Asn Leu Val Pro 
305                 310                 315                 320 


Phe Glu Leu Lys Asp Trp Lys Ile Ala Leu Ala Glu Leu Phe Arg Tyr 
                325                 330                 335     


Ile Asn Gly Thr Asp Cys Trp Ser Thr Ile Tyr Leu Glu Asn His Asp 
            340                 345                 350         


Gln Pro Arg Ser Ile Thr Arg Phe Gly Asp Asp Ser Pro Lys Asn Arg 
        355                 360                 365             


Val Ile Ser Gly Lys Leu Leu Ser Val Leu Leu Ser Ala Leu Thr Gly 
    370                 375                 380                 


Thr Leu Tyr Val Tyr Gln Gly Gln Glu Leu Gly Gln Ile Asn Phe Lys 
385                 390                 395                 400 


Asn Trp Pro Val Glu Lys Tyr Glu Asp Val Glu Ile Arg Asn Asn Tyr 
                405                 410                 415     


Asn Ala Ile Lys Glu Glu His Gly Glu Asn Ser Glu Glu Met Lys Lys 
            420                 425                 430         


Phe Leu Glu Gly Ile Ala Leu Val Ser Arg Asp His Ala Arg Thr Pro 
        435                 440                 445             


Met Pro Trp Thr Pro Asn Glu Pro Asn Ala Gly Phe Ser Gly Pro Ser 
    450                 455                 460                 


Ala Lys Pro Trp Phe Tyr Leu Asn Asp Ser Phe Arg Glu Gly Ile Asn 
465                 470                 475                 480 


Val Glu Asp Glu Ile Lys Asp Pro Asn Ser Val Leu Asn Phe Trp Lys 
                485                 490                 495     


Glu Ala Leu Lys Phe Arg Lys Ala His Lys Asp Ile Thr Val Tyr Gly 
            500                 505                 510         


Tyr Asp Phe Glu Phe Ile Asp Leu Asp Asn Lys Lys Leu Phe Ser Phe 
        515                 520                 525             


Thr Lys Lys Tyr Asn Asn Lys Thr Leu Phe Ala Ala Leu Asn Phe Ser 
    530                 535                 540                 


Ser Asp Ala Thr Asp Phe Lys Ile Pro Asn Asp Asp Ser Ser Phe Lys 
545                 550                 555                 560 


Leu Glu Phe Gly Asn Tyr Pro Lys Lys Glu Val Asp Ala Ser Ser Arg 
                565                 570                 575     


Thr Leu Lys Pro Trp Glu Gly Arg Ile Tyr Ile Ser Glu 
            580                 585                 


<210>  15
<211>  589
<212>  PRT
<213>  Hybrid yeast 1

<400>  15

Met Thr Ile Ser Ser Ala His Pro Glu Ala Glu Pro Lys Trp Trp Lys 
1               5                   10                  15      


Glu Ala Thr Phe Tyr Gln Ile Tyr Pro Ala Ser Phe Lys Asp Ser Asn 
            20                  25                  30          


Asp Asp Gly Trp Gly Asp Met Lys Gly Ile Ser Ser Lys Leu Glu Tyr 
        35                  40                  45              


Ile Lys Glu Leu Gly Ala Asp Ala Ile Trp Ile Ser Pro Phe Tyr Asp 
    50                  55                  60                  


Ser Pro Gln Asp Asp Met Gly Tyr Asp Ile Ala Asn Tyr Glu Lys Val 
65                  70                  75                  80  


Trp Pro Thr Tyr Gly Thr Asn Glu Asp Cys Phe Ala Leu Ile Glu Lys 
                85                  90                  95      


Thr His Lys Leu Gly Met Lys Phe Ile Thr Asp Leu Val Ile Asn His 
            100                 105                 110         


Cys Ser Ser Glu His Glu Trp Leu Lys Glu Ser Arg Ser Ser Lys Thr 
        115                 120                 125             


Asn Pro Lys Arg Asp Trp Phe Phe Trp Arg Pro Pro Lys Gly Tyr Asp 
    130                 135                 140                 


Ala Glu Gly Lys Pro Ile Pro Pro Asn Asn Trp Lys Ser Tyr Phe Gly 
145                 150                 155                 160 


Gly Ser Ala Trp Ile Phe Asp Glu Lys Thr Gln Glu Phe Tyr Leu Arg 
                165                 170                 175     


Leu Phe Cys Ser Thr Gln Pro Asp Leu Asn Trp Glu Asn Glu Asp Cys 
            180                 185                 190         


Arg Lys Ala Ile Tyr Glu Ser Ala Val Gly Tyr Trp Leu Asp His Gly 
        195                 200                 205             


Val Asp Gly Phe Arg Ile Asp Val Gly Ser Leu Tyr Ser Lys Val Val 
    210                 215                 220                 


Gly Leu Pro Asp Ala Pro Val Val Asp Lys Asn Ser Thr Trp Gln Ser 
225                 230                 235                 240 


Ser Asp Pro Tyr Thr Leu Asn Gly Pro Arg Ile His Glu Phe His Gln 
                245                 250                 255     


Glu Met Asn Gln Phe Ile Arg Asn Arg Val Lys Asp Gly Arg Glu Ile 
            260                 265                 270         


Met Thr Val Gly Glu Met Gln His Ala Ser Asp Glu Thr Lys Lys Leu 
        275                 280                 285             


Tyr Thr Ser Ala Ser Arg His Glu Leu Ser Glu Leu Phe Asn Phe Ser 
    290                 295                 300                 


His Thr Asp Val Gly Thr Ser Pro Leu Phe Arg Tyr Asn Leu Val Pro 
305                 310                 315                 320 


Phe Glu Leu Lys Asp Trp Lys Ile Ala Leu Ala Glu Leu Phe Arg Phe 
                325                 330                 335     


Ile Asn Gly Thr Asp Cys Trp Ser Thr Ile Tyr Leu Glu Asn His Asp 
            340                 345                 350         


Gln Pro Arg Ser Ile Thr Arg Phe Gly Asp Asp Ser Pro Lys Asn Arg 
        355                 360                 365             


Val Ile Ser Gly Lys Leu Leu Ser Val Leu Leu Ser Ala Leu Thr Gly 
    370                 375                 380                 


Thr Leu Tyr Val Tyr Gln Gly Gln Glu Leu Gly Gln Ile Asn Phe Lys 
385                 390                 395                 400 


Asn Trp Pro Val Glu Lys Tyr Glu Asp Val Glu Ile Arg Asn Asn Tyr 
                405                 410                 415     


Asn Ala Ile Lys Glu Glu His Gly Glu Asn Ser Glu Glu Met Lys Lys 
            420                 425                 430         


Phe Leu Glu Ala Ile Ala Leu Ile Ser Arg Asp His Ala Arg Thr Pro 
        435                 440                 445             


Met Gln Trp Ser Arg Glu Glu Pro Asn Ala Gly Phe Ser Gly Pro Ser 
    450                 455                 460                 


Ala Lys Pro Trp Phe Tyr Leu Asn Asp Ser Phe Arg Glu Gly Ile Asn 
465                 470                 475                 480 


Val Glu Asp Glu Ile Lys Asp Pro Asn Ser Val Leu Asn Phe Trp Lys 
                485                 490                 495     


Glu Ala Leu Lys Phe Arg Lys Ala His Lys Asp Ile Thr Val Tyr Gly 
            500                 505                 510         


Tyr Asp Phe Glu Phe Ile Asp Leu Asp Asn Lys Lys Leu Phe Ser Phe 
        515                 520                 525             


Thr Lys Lys Tyr Asn Asn Lys Thr Leu Phe Ala Ala Leu Asn Phe Ser 
    530                 535                 540                 


Ser Asp Ala Thr Asp Phe Lys Ile Pro Asn Asp Asp Ser Ser Phe Lys 
545                 550                 555                 560 


Leu Glu Phe Gly Asn Tyr Pro Lys Lys Glu Val Asp Ala Ser Ser Arg 
                565                 570                 575     


Thr Leu Lys Pro Trp Glu Gly Arg Ile Tyr Ile Ser Glu 
            580                 585                 


<210>  16
<211>  581
<212>  PRT
<213>  Hybrid yeast 1

<400>  16

Met Thr Ile Ile His Asn Pro Lys Trp Trp Lys Glu Ala Thr Ile Tyr 
1               5                   10                  15      


Gln Ile Tyr Pro Ala Ser Phe Lys Asp Ser Asn Asn Asp Gly Trp Gly 
            20                  25                  30          


Asp Leu Ala Gly Ile Thr Ser Lys Leu Asp Tyr Ile Lys Glu Leu Gly 
        35                  40                  45              


Val Asp Ala Ile Trp Val Cys Pro Phe Tyr Asp Ser Pro Gln Glu Asp 
    50                  55                  60                  


Met Gly Tyr Asp Ile Ala Asn Tyr Glu Lys Val Trp Pro Arg Tyr Gly 
65                  70                  75                  80  


Thr Ser Glu Asp Cys Phe Gln Met Ile Glu Glu Ser His Lys Arg Gly 
                85                  90                  95      


Ile Lys Val Ile Val Asp Leu Val Ile Asn His Cys Ser Glu Glu His 
            100                 105                 110         


Glu Trp Phe Lys Glu Ser Arg Ser Ser Lys Thr Asn Ala Lys Arg Asp 
        115                 120                 125             


Trp Phe Phe Trp Lys Pro Pro Lys Gly Tyr Glu Ile Asp Gly Thr Pro 
    130                 135                 140                 


Ile Pro Pro Asn Asn Trp Arg Ser Phe Phe Gly Gly Ser Ala Trp Lys 
145                 150                 155                 160 


Tyr Asp Glu Asn Thr Glu Glu Phe Phe Leu His Val Phe Ala Pro Gly 
                165                 170                 175     


Gln Pro Asp Phe Asn Trp Glu Asn Lys Glu Cys Arg Gln Ala Ile Tyr 
            180                 185                 190         


Asp Ser Ser Val Gly Phe Trp Leu Arg His Asn Val Asp Gly Phe Arg 
        195                 200                 205             


Ile Asp Val Gly Ser Met Tyr Ser Lys Val Glu Gly Leu Pro Asp Ala 
    210                 215                 220                 


Ser Ile Thr Asp Pro Thr Val Pro Tyr Gln Asp Gly Thr Asp Phe Phe 
225                 230                 235                 240 


Val Asn Gly Pro Arg Ile His Glu Tyr His Lys Glu Met Arg Gln Tyr 
                245                 250                 255     


Met Tyr Thr Gln Ile Pro Glu Gly Lys Glu Ile Met Thr Val Gly Glu 
            260                 265                 270         


Val Gly Ile Gly Asn Glu Lys Asp Phe Lys Asp Tyr Thr Ser Ser Lys 
        275                 280                 285             


Glu Glu Glu Phe Asn Met Met Phe Asn Phe Lys His Thr Ser Val Gly 
    290                 295                 300                 


Glu Ser Pro Glu Phe Lys Tyr Glu Leu Ile Pro Phe Thr Leu Lys Asp 
305                 310                 315                 320 


Phe Lys Leu Ala Leu Ala Glu Ser Phe Leu Phe Ile Glu Gly Thr Asp 
                325                 330                 335     


Cys Trp Ser Thr Ile Tyr Leu Glu Asn His Asp Gln Pro Arg Ser Val 
            340                 345                 350         


Ser Arg Phe Gly Ser Asp Ser Pro Glu Trp Arg Glu Ile Ser Ser Lys 
        355                 360                 365             


Met Leu Ala Thr Leu Ile Ile Ser Leu Thr Gly Thr Val Phe Ile Tyr 
    370                 375                 380                 


Gln Gly Gln Glu Leu Gly Met Pro Asn Phe Lys Asn Arg Lys Ile Glu 
385                 390                 395                 400 


Gln Ile Lys Cys Val Glu Gly Thr Gly Thr Tyr Gly Ala Ile Lys Arg 
                405                 410                 415     


Asp Tyr Gly Glu Asp Ser Glu Lys Met Lys Lys Phe Tyr Glu Ala Leu 
            420                 425                 430         


Ala Leu Ile Ser Arg Asp His Gly Arg Thr Pro Phe Pro Trp Ser Gly 
        435                 440                 445             


Glu Lys Pro Tyr Ala Gly Phe Ser Lys Asn Ala Lys Pro Trp Ile Asp 
    450                 455                 460                 


Ile Asn Glu Ser Phe Val Glu Gly Ile Asn Ala Glu Ala Glu Leu Asn 
465                 470                 475                 480 


Asp Glu Asn Ser Val Phe Phe Phe Trp Lys Arg Ala Leu Gln Val Arg 
                485                 490                 495     


Lys Glu His Lys Asn Met Leu Val Tyr Gly Asp Asn Phe Gln Phe Tyr 
            500                 505                 510         


Asp Leu Asp Asn Glu Lys Leu Phe Met Phe Thr Lys Asp Ser Gly Asp 
        515                 520                 525             


Lys Lys Met Phe Ala Val Phe Asn Phe Cys Ser Asp Ser Thr Glu Phe 
    530                 535                 540                 


Ser Val Pro Asp Asn Lys Ala Ser Tyr Asp Met Phe Phe Gly Asn Tyr 
545                 550                 555                 560 


Ala Asn Ser Asp Gly Lys Ser Tyr Thr Leu Lys Pro Trp Glu Gly Arg 
                565                 570                 575     


Leu Tyr Tyr Ser Asn 
            580     


<210>  17
<211>  581
<212>  PRT
<213>  Hybrid yeast 1

<400>  17

Met Thr Ile Ile His Asn Pro Lys Trp Trp Lys Glu Ala Thr Val Tyr 
1               5                   10                  15      


Gln Ile Tyr Pro Ala Ser Asn Lys Asp Ser Asn Asn Asp Gly Trp Gly 
            20                  25                  30          


Asp Leu Ala Gly Ile Thr Ser Lys Leu Asp Tyr Val Lys Glu Leu Gly 
        35                  40                  45              


Val Asp Ala Ile Trp Val Cys Leu Phe Tyr Asp Ser Pro Gln Glu Asp 
    50                  55                  60                  


Met Gly Tyr Asp Ile Ala Asn Tyr Glu Lys Val Trp Pro Arg Tyr Gly 
65                  70                  75                  80  


Thr Asn Glu Asp Cys Phe Gln Met Ile Glu Glu Ala His Lys Arg Gly 
                85                  90                  95      


Ile Lys Val Ile Val Asp Leu Val Ile Asn His Cys Ser Glu Glu His 
            100                 105                 110         


Glu Trp Phe Lys Glu Ser Lys Ser Ser Lys Thr Asn Pro Lys Arg Asp 
        115                 120                 125             


Trp Phe Phe Trp Arg Pro Pro Lys Gly Phe Asp Glu Lys Gly Asn Pro 
    130                 135                 140                 


Ile Pro Pro Asn Asn Trp Arg Ser Phe Phe Gly Gly Ser Ala Trp Arg 
145                 150                 155                 160 


Tyr Asp Glu Lys Thr Gly Glu Phe Phe Leu His Val Phe Ala Pro Gly 
                165                 170                 175     


Gln Pro Asp Phe Asn Trp Glu Asn Glu Glu Cys Arg Lys Ala Ile Tyr 
            180                 185                 190         


Asp Ser Ser Val Gly Tyr Trp Leu Arg His Asn Val Asp Gly Phe Arg 
        195                 200                 205             


Ile Asp Val Gly Ser Met Tyr Ser Lys Val Glu Gly Leu Pro Asp Ala 
    210                 215                 220                 


Pro Ile Thr Asp Pro Thr Val Pro Tyr Gln Lys Gly Thr Glu Phe Phe 
225                 230                 235                 240 


Ile Asn Gly Ser Arg Ile His Glu Tyr His Lys Glu Met Arg Lys Tyr 
                245                 250                 255     


Met Leu Ser Gln Ile Pro Glu Gly Lys Glu Ile Met Thr Val Gly Glu 
            260                 265                 270         


Val Gly Val Gly Asn Glu Glu Asp Phe Arg Asp Tyr Thr Ser Ala Lys 
        275                 280                 285             


Glu Gly Glu Leu Asn Met Met Phe Asn Phe Lys His Thr Ser Val Gly 
    290                 295                 300                 


Glu Ser Pro Glu Cys Lys Tyr Glu Leu Ile Pro Phe Thr Leu Lys Asp 
305                 310                 315                 320 


Phe Lys Leu Ala Leu Ala Glu Ser Phe Leu Phe Ile Glu Asn Thr Asp 
                325                 330                 335     


Cys Trp Ser Thr Ile Tyr Leu Glu Asn His Asp Gln Pro Arg Ser Val 
            340                 345                 350         


Ser Arg Phe Gly Ser Asp Ser Pro Lys Trp Arg Ala Ile Ser Ser Lys 
        355                 360                 365             


Met Leu Ala Thr Leu Ile Ile Ser Leu Thr Gly Thr Val Phe Ile Tyr 
    370                 375                 380                 


Gln Gly Gln Glu Leu Gly Met Ser Asn Phe Lys Asn Arg Arg Ile Glu 
385                 390                 395                 400 


Gln Ile Lys Cys Val Glu Gly Thr Gly Thr Tyr Ala Ala Ile Lys Arg 
                405                 410                 415     


Asp Tyr Gly Glu Asp Ser Glu Lys Met Lys Lys Phe Phe Glu Ala Leu 
            420                 425                 430         


Ala Leu Ile Ser Arg Asp His Gly Arg Thr Pro Phe Pro Trp Ser Ala 
        435                 440                 445             


Asp Glu Pro Ser Ala Gly Phe Ser Lys Asp Ala Lys Pro Arg Ile Asp 
    450                 455                 460                 


Met Asn Glu Ser Phe Arg Asp Gly Ile Asn Ala Glu Ala Glu Leu Lys 
465                 470                 475                 480 


Asp Lys Asn Ser Val Phe Phe Phe Trp Lys Lys Ala Leu Gln Val Arg 
                485                 490                 495     


Lys Glu His Lys Asp Ile Leu Val Tyr Gly His Asn Phe Gln Phe Ile 
            500                 505                 510         


Asp Leu Asp Asn Asp Lys Leu Phe Met Phe Thr Lys Asp Thr Asp Asn 
        515                 520                 525             


Lys Lys Met Phe Ala Val Phe Asn Phe Ser Ser Asp Asp Thr Asp Phe 
    530                 535                 540                 


Ser Val Pro Asp Asn Glu Ala Ser Tyr Thr Met Phe Phe Gly Asn Tyr 
545                 550                 555                 560 


Ala Asn Ser Asn Gly Asp Ser Arg Thr Leu Gln Pro Trp Glu Gly Arg 
                565                 570                 575     


Leu Tyr Leu Leu Lys 
            580     


<210>  18
<211>  610
<212>  PRT
<213>  Hybrid yeast 1

<400>  18

Met Lys Asn Ile Leu Ser Leu Val Gly Arg Lys Glu Asn Thr Pro Glu 
1               5                   10                  15      


Asp Val Thr Ala Asn Leu Ala Asp Thr Ser Ser Thr Thr Val Met Gln 
            20                  25                  30          


Ala Lys Asp Leu Val Ile Glu Asp Phe Glu Glu Arg Lys Lys Asn Asp 
        35                  40                  45              


Ala Phe Glu Leu Asn His Leu Glu Leu Thr Thr Asn Ala Thr Gln Leu 
    50                  55                  60                  


Ser Asp Ser Asp Glu Asp Lys Glu Asn Val Ile Arg Val Ala Glu Ala 
65                  70                  75                  80  


Thr Asp Asp Ala Asn Glu Ala Asn Asn Glu Glu Lys Ser Met Thr Leu 
                85                  90                  95      


Arg Gln Ala Leu Arg Lys Tyr Pro Lys Ala Ala Leu Trp Ser Ile Leu 
            100                 105                 110         


Val Ser Thr Thr Leu Val Met Glu Gly Tyr Asp Thr Ala Leu Leu Ser 
        115                 120                 125             


Ala Leu Tyr Ala Leu Pro Val Phe Gln Arg Lys Phe Gly Thr Met Asn 
    130                 135                 140                 


Ala Glu Gly Ser Tyr Glu Ile Thr Ser Gln Trp Gln Ile Gly Leu Asn 
145                 150                 155                 160 


Met Cys Val Leu Cys Gly Glu Met Ile Gly Leu Gln Ile Thr Thr Tyr 
                165                 170                 175     


Met Val Glu Phe Met Gly Asn Arg Tyr Thr Met Ile Thr Ala Leu Ser 
            180                 185                 190         


Leu Leu Thr Ala Tyr Ile Phe Ile Leu Tyr Tyr Cys Lys Ser Leu Ala 
        195                 200                 205             


Met Ile Ala Val Gly Gln Ile Leu Ser Ala Met Pro Trp Gly Cys Phe 
    210                 215                 220                 


Gln Ser Leu Ala Val Thr Tyr Ala Ser Glu Val Cys Pro Leu Ala Leu 
225                 230                 235                 240 


Arg Tyr Tyr Met Thr Ser Tyr Ser Asn Ile Cys Trp Leu Phe Gly Gln 
                245                 250                 255     


Ile Phe Ala Ser Gly Ile Met Lys Asn Ser Gln Glu Asn Leu Gly Asn 
            260                 265                 270         


Ser Asp Leu Gly Tyr Lys Leu Pro Phe Ala Leu Gln Trp Ile Trp Pro 
        275                 280                 285             


Ala Pro Leu Ile Ile Gly Ile Phe Phe Ala Pro Glu Ser Pro Trp Trp 
    290                 295                 300                 


Leu Val Arg Lys Asn Lys Ile Val Glu Ala Lys Lys Ser Leu Asn Arg 
305                 310                 315                 320 


Ile Leu Ser Gly Thr Val Thr Glu Lys Glu Ile Gln Val Asp Ile Thr 
                325                 330                 335     


Leu Lys Gln Ile Glu Met Thr Ile Glu Lys Glu Arg Leu Arg Ala Ser 
            340                 345                 350         


Lys Ser Gly Ser Phe Phe Ser Cys Phe Lys Gly Val Asp Gly Arg Arg 
        355                 360                 365             


Thr Arg Leu Ala Cys Leu Thr Trp Val Ala Gln Asn Ser Ser Gly Ala 
    370                 375                 380                 


Val Leu Leu Gly Tyr Ser Thr Tyr Phe Phe Glu Arg Ala Gly Met Ala 
385                 390                 395                 400 


Thr Asp Lys Ala Phe Thr Phe Ser Leu Ile Gln Tyr Cys Leu Gly Leu 
                405                 410                 415     


Ala Gly Thr Leu Gly Ser Trp Val Ile Ser Gly Arg Val Gly Arg Trp 
            420                 425                 430         


Thr Ile Leu Thr Tyr Gly Leu Ser Phe Gln Met Val Cys Leu Phe Ile 
        435                 440                 445             


Ile Gly Gly Met Gly Phe Ala Ser Gly Ser Ser Ala Ser Asn Ala Ala 
    450                 455                 460                 


Gly Gly Leu Leu Leu Ala Leu Ser Phe Phe Tyr Asn Ala Gly Ile Gly 
465                 470                 475                 480 


Ala Val Val Tyr Cys Ile Val Ala Glu Ile Pro Ser Ala Glu Leu Arg 
                485                 490                 495     


Thr Lys Thr Ile Val Leu Ala Arg Ile Cys Tyr Asn Leu Met Ala Val 
            500                 505                 510         


Phe Asn Ala Ile Leu Thr Pro Tyr Met Leu Asn Val Ser Asp Trp Asn 
        515                 520                 525             


Trp Gly Ala Lys Thr Gly Leu Tyr Trp Gly Gly Phe Thr Ala Leu Thr 
    530                 535                 540                 


Leu Ala Trp Val Ile Ile Asp Leu Pro Glu Thr Thr Gly Arg Thr Phe 
545                 550                 555                 560 


Ser Glu Ile Asn Glu Leu Phe Ser Gln Gly Val Pro Ala Arg Lys Phe 
                565                 570                 575     


Ala Ser Thr Val Val Asp Pro Phe Gly Lys Arg Gly Leu Gln Asn Arg 
            580                 585                 590         


Pro Gln Val Asp Asn Ile Ile Asp Arg Phe Ser Ser Ala Ser Gln Gln 
        595                 600                 605             


Ala Leu 
    610 


<210>  19
<211>  616
<212>  PRT
<213>  Hybrid yeast 1

<400>  19

Met Lys Asn Ile Ile Ser Leu Val Ser Lys Lys Lys Ala Ala Ser Lys 
1               5                   10                  15      


Asn Glu Asp Lys Asn Ile Ser Glu Ser Ser Arg Asp Ile Val Asn Gln 
            20                  25                  30          


Gln Glu Val Phe Asn Thr Glu Asn Phe Glu Glu Gly Arg Lys Asp Ser 
        35                  40                  45              


Ala Phe Glu Leu Asp His Leu Glu Phe Thr Ile Asn Ser Ala Gln Leu 
    50                  55                  60                  


Gly Asp Ser Asp Glu Asp Asn Glu Asn Val Ile Asn Glu Thr Asn Thr 
65                  70                  75                  80  


Thr Asp Asp Ala Asn Glu Ala Asn Ser Glu Glu Lys Ser Met Thr Leu 
                85                  90                  95      


Lys Gln Ala Leu Leu Ile Tyr Pro Lys Ala Ala Leu Trp Ser Ile Leu 
            100                 105                 110         


Val Ser Thr Thr Leu Val Met Glu Gly Tyr Asp Thr Ala Leu Leu Asn 
        115                 120                 125             


Ala Leu Tyr Ala Leu Pro Val Phe Gln Arg Lys Phe Gly Thr Leu Asn 
    130                 135                 140                 


Gly Glu Gly Ser Tyr Glu Ile Thr Ser Gln Trp Gln Ile Gly Leu Asn 
145                 150                 155                 160 


Met Cys Val Gln Cys Gly Glu Ile Ile Gly Leu Gln Ile Thr Pro Tyr 
                165                 170                 175     


Met Val Glu Phe Met Gly Asn Arg Tyr Thr Met Ile Thr Ala Leu Gly 
            180                 185                 190         


Leu Leu Thr Ala Tyr Val Phe Ile Leu Tyr Tyr Cys Lys Ser Leu Ala 
        195                 200                 205             


Met Ile Ala Val Gly Gln Val Leu Ser Ala Met Pro Trp Gly Cys Phe 
    210                 215                 220                 


Gln Gly Leu Thr Val Thr Tyr Ala Ser Glu Val Cys Pro Leu Ala Leu 
225                 230                 235                 240 


Arg Tyr Tyr Met Thr Ser Tyr Ser Asn Ile Cys Trp Leu Phe Gly Gln 
                245                 250                 255     


Ile Phe Ala Ser Gly Ile Met Lys Asn Ser Gln Glu Asn Leu Gly Asn 
            260                 265                 270         


Ser Asp Leu Gly Tyr Lys Leu Pro Phe Ala Leu Gln Trp Ile Trp Pro 
        275                 280                 285             


Ala Pro Leu Met Ile Gly Ile Phe Phe Ala Pro Glu Ser Pro Trp Trp 
    290                 295                 300                 


Leu Val Arg Lys Asp Arg Val Ala Glu Ala Arg Lys Ser Leu Ser Arg 
305                 310                 315                 320 


Ile Leu Ser Gly Lys Gly Ala Glu Lys Asp Ile Gln Ile Asp Leu Thr 
                325                 330                 335     


Leu Lys Gln Ile Glu Leu Thr Ile Glu Lys Glu Arg Leu Leu Ala Ser 
            340                 345                 350         


Lys Ser Gly Ser Phe Leu Asp Cys Phe Lys Gly Val Asn Gly Arg Arg 
        355                 360                 365             


Thr Arg Leu Ala Cys Leu Thr Trp Val Ala Gln Asn Thr Ser Gly Ala 
    370                 375                 380                 


Cys Leu Leu Gly Tyr Ser Thr Tyr Phe Phe Glu Arg Ala Gly Met Ala 
385                 390                 395                 400 


Thr Asp Lys Ala Phe Thr Phe Ser Val Ile Gln Tyr Cys Leu Gly Leu 
                405                 410                 415     


Ala Gly Thr Leu Cys Ser Trp Val Ile Ser Gly Arg Val Gly Arg Trp 
            420                 425                 430         


Thr Ile Leu Thr Tyr Gly Leu Ala Phe Gln Met Val Cys Leu Phe Ile 
        435                 440                 445             


Ile Gly Gly Met Gly Phe Gly Ser Gly Ser Gly Ala Ser Asn Gly Ala 
    450                 455                 460                 


Gly Gly Leu Leu Leu Ala Leu Ser Phe Phe Tyr Asn Ala Gly Ile Gly 
465                 470                 475                 480 


Ala Val Val Tyr Cys Ile Val Thr Glu Ile Pro Ser Ala Glu Leu Arg 
                485                 490                 495     


Thr Lys Thr Ile Val Leu Ala Arg Ile Cys Tyr Asn Ile Met Ala Val 
            500                 505                 510         


Ile Asn Ala Ile Leu Thr Pro Tyr Met Leu Asn Val Ser Asp Trp Asn 
        515                 520                 525             


Trp Gly Ala Lys Thr Gly Leu Tyr Trp Gly Gly Phe Thr Ala Val Thr 
    530                 535                 540                 


Leu Ala Trp Val Ile Ile Asp Leu Pro Glu Thr Ser Gly Arg Thr Phe 
545                 550                 555                 560 


Ser Glu Ile Asn Glu Leu Phe Asn Gln Gly Val Pro Ala Arg Lys Phe 
                565                 570                 575     


Ala Ser Thr Val Val Asp Pro Phe Gly Lys Gly Lys Thr Gln His Asp 
            580                 585                 590         


Ser Leu Asp Asp Glu Ser Ile Ser Gln Ser Ser Ser Ile Lys Gln Arg 
        595                 600                 605             


Glu Leu Asn Ala Ala Asp Lys Cys 
    610                 615     


<210>  20
<211>  616
<212>  PRT
<213>  Hybrid yeast 1

<400>  20

Met Lys Asn Ile Ile Ser Leu Val Ser Lys Lys Lys Ala Ala Ser Lys 
1               5                   10                  15      


Asn Glu Asp Lys Asn Ile Ser Glu Ser Ser Arg Asp Ile Val Asn Gln 
            20                  25                  30          


Gln Glu Val Phe Asn Thr Glu Asn Phe Glu Glu Gly Arg Lys Asp Ser 
        35                  40                  45              


Ala Phe Glu Leu Asp His Leu Glu Phe Thr Ile Asn Ser Ala Gln Leu 
    50                  55                  60                  


Gly Asp Ser Asp Glu Asp Asn Glu Asn Val Ile Asn Glu Thr Asn Thr 
65                  70                  75                  80  


Thr Asp Asp Ala Asn Glu Ala Asn Ser Glu Glu Lys Ser Met Thr Leu 
                85                  90                  95      


Lys Gln Ala Leu Leu Ile Tyr Pro Lys Ala Ala Leu Trp Ser Ile Leu 
            100                 105                 110         


Val Ser Thr Thr Leu Val Met Glu Gly Tyr Asp Thr Ala Leu Leu Asn 
        115                 120                 125             


Ala Leu Tyr Ala Leu Pro Val Phe Gln Arg Lys Phe Gly Thr Leu Asn 
    130                 135                 140                 


Gly Glu Gly Ser Tyr Glu Ile Thr Ser Gln Trp Gln Ile Gly Leu Asn 
145                 150                 155                 160 


Met Cys Val Gln Cys Gly Glu Ile Ile Gly Leu Gln Ile Thr Pro Tyr 
                165                 170                 175     


Met Val Glu Phe Met Gly Asn Arg Tyr Thr Met Ile Thr Ala Leu Gly 
            180                 185                 190         


Leu Leu Thr Ala Tyr Val Phe Ile Leu Tyr Tyr Cys Lys Ser Leu Ala 
        195                 200                 205             


Met Ile Ala Val Gly Gln Val Leu Ser Ala Met Pro Trp Gly Cys Phe 
    210                 215                 220                 


Gln Gly Leu Thr Val Thr Tyr Ala Ser Glu Val Cys Pro Leu Ala Leu 
225                 230                 235                 240 


Arg Tyr Tyr Met Thr Ser Tyr Ser Asn Ile Cys Trp Leu Phe Gly Gln 
                245                 250                 255     


Ile Phe Ala Ser Gly Ile Met Lys Asn Ser Gln Glu Asn Leu Gly Asn 
            260                 265                 270         


Ser Asp Leu Gly Tyr Lys Leu Pro Phe Ala Leu Gln Trp Ile Trp Pro 
        275                 280                 285             


Ala Pro Leu Met Ile Gly Ile Phe Phe Ala Pro Glu Ser Pro Trp Trp 
    290                 295                 300                 


Leu Val Arg Lys Asp Arg Val Ala Glu Ala Arg Lys Ser Leu Ser Arg 
305                 310                 315                 320 


Ile Leu Ser Gly Lys Gly Ala Glu Lys Asp Ile Gln Ile Asp Leu Thr 
                325                 330                 335     


Leu Lys Gln Ile Glu Leu Thr Ile Glu Lys Glu Arg Leu Leu Ala Ser 
            340                 345                 350         


Lys Ser Gly Ser Phe Phe Asp Cys Phe Lys Gly Val Asn Gly Arg Arg 
        355                 360                 365             


Thr Arg Leu Ala Cys Leu Thr Trp Val Ala Gln Asn Thr Ser Gly Ala 
    370                 375                 380                 


Cys Leu Leu Gly Tyr Ser Ala Tyr Phe Phe Glu Arg Ala Gly Met Ala 
385                 390                 395                 400 


Thr Asp Lys Ala Phe Thr Phe Ser Val Ile Gln Tyr Cys Leu Gly Leu 
                405                 410                 415     


Ala Gly Thr Leu Cys Ser Trp Val Ile Ser Gly Arg Val Gly Arg Trp 
            420                 425                 430         


Thr Ile Leu Thr Tyr Gly Leu Ala Phe Gln Met Val Cys Leu Phe Ile 
        435                 440                 445             


Ile Gly Gly Met Gly Phe Gly Ser Gly Ser Gly Ala Ser Asn Gly Ala 
    450                 455                 460                 


Gly Gly Leu Leu Leu Ala Leu Ser Phe Phe Tyr Asn Ala Gly Ile Gly 
465                 470                 475                 480 


Ala Val Val Tyr Cys Ile Val Thr Glu Ile Pro Ser Ala Glu Leu Arg 
                485                 490                 495     


Thr Lys Thr Ile Val Leu Ala Arg Ile Cys Tyr Asn Ile Met Ala Val 
            500                 505                 510         


Ile Asn Ala Ile Leu Thr Pro Tyr Met Leu Asn Val Ser Asp Trp Asn 
        515                 520                 525             


Trp Gly Ala Lys Thr Gly Leu Tyr Trp Gly Gly Phe Thr Ala Val Thr 
    530                 535                 540                 


Leu Ala Trp Val Ile Ile Asp Leu Pro Glu Thr Ser Gly Arg Thr Phe 
545                 550                 555                 560 


Ser Glu Ile Asn Glu Leu Phe Asn Gln Gly Val Pro Ala Arg Lys Phe 
                565                 570                 575     


Ala Ser Thr Val Val Asp Pro Phe Gly Lys Gly Lys Thr Gln His Asp 
            580                 585                 590         


Ser Leu Asp Asp Glu Ser Ile Ser Gln Ser Ser Ser Ile Lys Gln Arg 
        595                 600                 605             


Glu Leu Asn Ala Ala Asp Lys Cys 
    610                 615     


<210>  21
<211>  589
<212>  PRT
<213>  Hybrid yeast 4

<400>  21

Met Thr Ile Ser Ser Ala His Pro Glu Thr Glu Pro Lys Trp Trp Lys 
1               5                   10                  15      


Glu Ala Thr Phe Tyr Gln Ile Tyr Pro Ala Ser Phe Lys Asp Ser Asn 
            20                  25                  30          


Asp Asp Gly Trp Gly Asp Met Lys Gly Ile Ser Ser Lys Leu Glu Tyr 
        35                  40                  45              


Ile Lys Glu Leu Gly Val Asp Ala Ile Trp Ile Ser Pro Phe Tyr Asp 
    50                  55                  60                  


Ser Pro Gln Asp Asp Met Gly Tyr Asp Ile Ala Asn Tyr Glu Lys Val 
65                  70                  75                  80  


Trp Pro Thr Tyr Gly Thr Asn Glu Asp Cys Phe Ala Leu Ile Glu Lys 
                85                  90                  95      


Thr His Lys Leu Gly Met Lys Phe Ile Thr Asp Leu Val Ile Asn His 
            100                 105                 110         


Cys Ser Ser Glu His Glu Trp Phe Lys Glu Ser Arg Ser Ser Lys Thr 
        115                 120                 125             


Asn Pro Lys Arg Asp Trp Phe Phe Trp Arg Pro Pro Lys Gly Tyr Asp 
    130                 135                 140                 


Ala Glu Gly Lys Pro Ile Pro Pro Asn Asn Trp Lys Ser Tyr Phe Gly 
145                 150                 155                 160 


Gly Ser Ala Trp Ile Phe Asp Glu Lys Thr Gln Glu Phe Tyr Leu Arg 
                165                 170                 175     


Leu Phe Cys Ser Thr Gln Pro Asp Leu Asn Trp Glu Asn Glu Asp Cys 
            180                 185                 190         


Arg Lys Ala Ile Tyr Glu Ser Ala Val Gly Tyr Trp Leu Asp His Gly 
        195                 200                 205             


Val Asp Gly Phe Arg Ile Asp Val Gly Ser Leu Tyr Ser Lys Val Val 
    210                 215                 220                 


Gly Leu Pro Asp Ala Pro Val Val Asp Lys Asn Ser Thr Trp Gln Ser 
225                 230                 235                 240 


Ser Asp Pro Tyr Thr Leu Asn Gly Pro Arg Ile His Glu Phe His Gln 
                245                 250                 255     


Glu Met Asn Gln Phe Ile Arg Asn Arg Val Lys Asp Gly Arg Glu Ile 
            260                 265                 270         


Met Thr Val Gly Glu Met Gln His Ala Ser Asp Glu Thr Lys Arg Leu 
        275                 280                 285             


Tyr Thr Ser Ala Ser Arg His Glu Leu Ser Glu Leu Phe Asn Phe Ser 
    290                 295                 300                 


His Thr Asp Val Gly Thr Ser Pro Leu Phe Arg Tyr Asn Leu Val Pro 
305                 310                 315                 320 


Phe Glu Leu Lys Asp Trp Lys Ile Ala Leu Ala Glu Leu Phe Arg Phe 
                325                 330                 335     


Ile Asn Gly Thr Asp Cys Trp Ser Thr Ile Tyr Leu Glu Asn His Asp 
            340                 345                 350         


Gln Pro Arg Ser Ile Thr Arg Phe Gly Asp Asp Ser Pro Lys Asn Arg 
        355                 360                 365             


Val Ile Ser Gly Lys Leu Leu Ser Val Leu Leu Ser Ala Leu Thr Gly 
    370                 375                 380                 


Thr Leu Tyr Val Tyr Gln Gly Gln Glu Leu Gly Gln Ile Asn Phe Lys 
385                 390                 395                 400 


Asn Trp Pro Val Glu Lys Tyr Glu Asp Val Glu Ile Arg Asn Asn Tyr 
                405                 410                 415     


Asn Ala Ile Lys Glu Glu His Gly Glu Asn Ser Glu Glu Met Lys Lys 
            420                 425                 430         


Phe Leu Glu Ala Ile Ala Leu Ile Ser Arg Asp His Ala Arg Thr Pro 
        435                 440                 445             


Met Gln Trp Ser Arg Glu Glu Pro Asn Ala Gly Phe Ser Gly Pro Ser 
    450                 455                 460                 


Ala Lys Pro Trp Phe Tyr Leu Asn Asp Ser Phe Arg Glu Gly Ile Asn 
465                 470                 475                 480 


Val Glu Asp Glu Ile Lys Asp Pro Asn Ser Val Leu Asn Phe Trp Lys 
                485                 490                 495     


Glu Ala Leu Lys Phe Arg Lys Ala His Lys Asp Ile Thr Val Tyr Gly 
            500                 505                 510         


Tyr Asp Phe Glu Phe Ile Asp Leu Asp Asn Lys Lys Leu Phe Ser Phe 
        515                 520                 525             


Thr Lys Lys Tyr Asn Asn Lys Thr Leu Phe Ala Ala Leu Asn Phe Ser 
    530                 535                 540                 


Ser Asp Ala Thr Asp Phe Lys Ile Pro Asn Asp Asp Ser Ser Phe Lys 
545                 550                 555                 560 


Leu Glu Phe Gly Asn Tyr Pro Lys Lys Glu Val Asp Ala Ser Ser Arg 
                565                 570                 575     


Thr Leu Lys Pro Trp Glu Gly Arg Ile Tyr Ile Ser Glu 
            580                 585                 


<210>  22
<211>  589
<212>  PRT
<213>  Hybrid yeast 4

<400>  22

Met Thr Ile Ser Ser Ala His Pro Glu Thr Glu Pro Lys Trp Trp Lys 
1               5                   10                  15      


Glu Ala Thr Phe Tyr Gln Ile Tyr Pro Ala Ser Phe Lys Asp Ser Asn 
            20                  25                  30          


Asp Asp Gly Trp Gly Asp Met Lys Gly Ile Ser Ser Lys Leu Glu Tyr 
        35                  40                  45              


Ile Lys Glu Leu Gly Val Asp Ala Ile Trp Ile Ser Pro Phe Tyr Asp 
    50                  55                  60                  


Ser Pro Gln Asp Asp Met Gly Tyr Asp Ile Ala Asn Tyr Glu Lys Val 
65                  70                  75                  80  


Trp Pro Thr Tyr Gly Thr Asn Glu Asp Cys Phe Ala Leu Ile Glu Lys 
                85                  90                  95      


Thr His Lys Leu Gly Met Lys Phe Ile Thr Asp Leu Val Ile Asn His 
            100                 105                 110         


Cys Ser Ser Glu His Glu Trp Phe Lys Glu Ser Arg Ser Ser Lys Thr 
        115                 120                 125             


Asn Pro Lys Arg Asp Trp Phe Phe Trp Arg Pro Pro Lys Gly Tyr Asp 
    130                 135                 140                 


Ala Glu Gly Lys Pro Ile Pro Pro Asn Asn Trp Lys Ser Tyr Phe Gly 
145                 150                 155                 160 


Gly Ser Ala Trp Ile Phe Asp Glu Lys Thr Gln Glu Phe Tyr Leu Arg 
                165                 170                 175     


Leu Phe Cys Ser Thr Gln Pro Asp Leu Asn Trp Glu Asn Glu Asp Cys 
            180                 185                 190         


Arg Lys Ala Ile Tyr Glu Ser Ala Val Gly Tyr Trp Leu Asp His Gly 
        195                 200                 205             


Val Asp Gly Phe Arg Ile Asp Val Gly Ser Leu Tyr Ser Lys Val Val 
    210                 215                 220                 


Gly Leu Pro Asp Ala Pro Val Val Asp Lys Asn Ser Thr Trp Gln Ser 
225                 230                 235                 240 


Ser Asp Pro Tyr Thr Leu Asn Gly Pro Arg Ile His Glu Phe His Gln 
                245                 250                 255     


Glu Met Asn Gln Phe Ile Arg Asn Arg Val Lys Asp Gly Arg Glu Ile 
            260                 265                 270         


Met Thr Val Gly Glu Met Gln His Ala Ser Asp Glu Thr Lys Arg Leu 
        275                 280                 285             


Tyr Thr Ser Ala Ser Arg His Glu Leu Ser Glu Leu Phe Asn Phe Ser 
    290                 295                 300                 


His Thr Asp Val Gly Thr Ser Pro Leu Phe Arg Tyr Asn Leu Val Pro 
305                 310                 315                 320 


Phe Glu Leu Lys Asp Trp Lys Ile Ala Leu Ala Glu Leu Phe Arg Tyr 
                325                 330                 335     


Ile Asn Gly Thr Asp Cys Trp Ser Thr Ile Tyr Leu Glu Asn His Asp 
            340                 345                 350         


Gln Pro Arg Ser Ile Thr Arg Phe Gly Asp Asp Ser Pro Lys Asn Arg 
        355                 360                 365             


Val Ile Ser Gly Lys Leu Leu Ser Val Leu Leu Ser Ala Leu Thr Gly 
    370                 375                 380                 


Thr Leu Tyr Val Tyr Gln Gly Gln Glu Leu Gly Gln Ile Asn Phe Lys 
385                 390                 395                 400 


Asn Trp Pro Val Glu Lys Tyr Glu Asp Val Glu Ile Arg Asn Asn Tyr 
                405                 410                 415     


Asn Ala Ile Lys Glu Glu His Gly Glu Asn Ser Glu Glu Met Lys Lys 
            420                 425                 430         


Phe Leu Glu Ala Ile Ala Leu Ile Ser Arg Asp His Ala Arg Thr Pro 
        435                 440                 445             


Met Gln Trp Ser Arg Glu Glu Pro Asn Ala Gly Phe Ser Gly Pro Ser 
    450                 455                 460                 


Ala Lys Pro Trp Phe Tyr Leu Asn Asp Ser Phe Arg Glu Gly Ile Asn 
465                 470                 475                 480 


Val Glu Asp Glu Ile Lys Asp Pro Asn Ser Val Leu Asn Phe Trp Lys 
                485                 490                 495     


Glu Ala Leu Lys Phe Arg Lys Ala His Lys Asp Ile Thr Val Tyr Gly 
            500                 505                 510         


Tyr Asp Phe Glu Phe Ile Asp Leu Asp Asn Lys Lys Leu Phe Ser Phe 
        515                 520                 525             


Thr Lys Lys Tyr Asn Asn Lys Thr Leu Phe Ala Ala Leu Asn Phe Ser 
    530                 535                 540                 


Ser Asp Ala Thr Asp Phe Lys Ile Pro Asn Asp Asp Ser Ser Phe Lys 
545                 550                 555                 560 


Leu Glu Phe Gly Asn Tyr Pro Lys Lys Glu Val Asp Ala Ser Ser Arg 
                565                 570                 575     


Thr Leu Lys Pro Trp Glu Gly Arg Ile Tyr Ile Ser Glu 
            580                 585                 


<210>  23
<211>  589
<212>  PRT
<213>  Hybrid yeast 7

<400>  23

Met Thr Ile Ser Ser Ala His Pro Glu Thr Glu Pro Lys Trp Trp Lys 
1               5                   10                  15      


Glu Ala Thr Phe Tyr Gln Ile Tyr Pro Ala Ser Phe Lys Asp Ser Asn 
            20                  25                  30          


Asp Asp Gly Trp Gly Asp Met Lys Gly Ile Ser Ser Lys Leu Glu Tyr 
        35                  40                  45              


Ile Lys Glu Leu Gly Val Asp Ala Ile Trp Ile Ser Pro Phe Tyr Asp 
    50                  55                  60                  


Ser Pro Gln Asp Asp Met Gly Tyr Asp Ile Ala Asn Tyr Glu Lys Val 
65                  70                  75                  80  


Trp Pro Thr Tyr Gly Thr Asn Glu Asp Cys Phe Ala Leu Ile Glu Lys 
                85                  90                  95      


Thr His Lys Leu Gly Met Lys Phe Ile Thr Asp Leu Val Ile Asn His 
            100                 105                 110         


Cys Ser Ser Glu His Glu Trp Phe Lys Glu Ser Arg Ser Ser Lys Thr 
        115                 120                 125             


Asn Pro Lys Arg Asp Trp Phe Phe Trp Arg Pro Pro Lys Gly Tyr Asp 
    130                 135                 140                 


Ala Glu Gly Lys Pro Ile Pro Pro Asn Asn Trp Lys Ser Tyr Phe Gly 
145                 150                 155                 160 


Gly Ser Ala Trp Ile Phe Asp Glu Lys Thr Gln Glu Phe Tyr Leu Arg 
                165                 170                 175     


Leu Phe Cys Ser Thr Gln Pro Asp Leu Asn Trp Glu Asn Glu Asp Cys 
            180                 185                 190         


Arg Lys Ala Ile Tyr Glu Ser Ala Val Gly Tyr Trp Leu Asp His Gly 
        195                 200                 205             


Val Asp Gly Phe Arg Ile Asp Val Gly Ser Leu Tyr Ser Lys Val Val 
    210                 215                 220                 


Gly Leu Pro Asp Ala Pro Val Val Asp Lys Asn Ser Thr Trp Gln Ser 
225                 230                 235                 240 


Ser Asp Pro Tyr Thr Leu Asn Gly Pro Arg Ile His Glu Phe His Gln 
                245                 250                 255     


Glu Met Asn Gln Phe Ile Arg Asn Arg Val Lys Asp Gly Arg Glu Ile 
            260                 265                 270         


Met Thr Val Gly Glu Met Gln His Ala Ser Asp Glu Thr Lys Lys Leu 
        275                 280                 285             


Tyr Thr Ser Ala Ser Arg His Glu Leu Ser Glu Leu Phe Asn Phe Ser 
    290                 295                 300                 


His Thr Asp Val Gly Thr Ser Pro Leu Phe Arg Tyr Asn Leu Val Pro 
305                 310                 315                 320 


Phe Glu Leu Lys Asp Trp Lys Ile Ala Leu Ala Glu Leu Phe Arg Phe 
                325                 330                 335     


Ile Asn Gly Thr Asp Cys Trp Ser Thr Ile Tyr Leu Glu Asn His Asp 
            340                 345                 350         


Gln Pro Arg Ser Ile Thr Arg Phe Gly Asp Asp Ser Pro Lys Asn Arg 
        355                 360                 365             


Val Ile Ser Gly Lys Leu Leu Ser Val Leu Leu Ser Ala Leu Thr Gly 
    370                 375                 380                 


Thr Leu Tyr Val Tyr Gln Gly Gln Glu Leu Gly Gln Ile Asn Phe Lys 
385                 390                 395                 400 


Asn Trp Pro Val Glu Lys Tyr Glu Asp Val Glu Ile Arg Asn Asn Tyr 
                405                 410                 415     


Asn Ala Ile Lys Glu Glu His Gly Glu Asn Ser Glu Glu Met Lys Lys 
            420                 425                 430         


Phe Leu Glu Ala Ile Ala Leu Ile Ser Arg Asp His Ala Arg Thr Pro 
        435                 440                 445             


Met Gln Trp Ser Arg Glu Glu Pro Asn Ala Gly Phe Ser Gly Pro Ser 
    450                 455                 460                 


Ala Lys Pro Trp Phe Tyr Leu Asn Asp Ser Phe Arg Glu Gly Ile Asn 
465                 470                 475                 480 


Val Glu Asp Glu Ile Lys Asp Pro Asn Ser Val Leu Asn Phe Trp Lys 
                485                 490                 495     


Glu Ala Leu Lys Phe Arg Lys Ala His Lys Asp Ile Thr Val Tyr Gly 
            500                 505                 510         


Tyr Asp Phe Glu Phe Ile Asp Leu Asp Asn Lys Lys Leu Phe Ser Phe 
        515                 520                 525             


Thr Lys Lys Tyr Asn Asn Lys Thr Leu Phe Ala Ala Leu Asn Phe Ser 
    530                 535                 540                 


Ser Asp Ala Thr Asp Phe Lys Ile Pro Asn Asp Asp Ser Ser Phe Lys 
545                 550                 555                 560 


Leu Glu Phe Gly Asn Tyr Pro Lys Lys Glu Val Asp Ala Ser Ser Arg 
                565                 570                 575     


Thr Leu Lys Pro Trp Glu Gly Arg Ile Tyr Ile Ser Glu 
            580                 585                 


<210>  24
<211>  589
<212>  PRT
<213>  Hybrid yeast 7

<400>  24

Met Thr Ile Ser Ser Ala His Pro Glu Thr Glu Pro Lys Trp Trp Lys 
1               5                   10                  15      


Glu Ala Thr Phe Tyr Gln Ile Tyr Pro Ala Ser Phe Lys Asp Ser Asn 
            20                  25                  30          


Asp Asp Gly Trp Gly Asp Met Lys Gly Ile Ser Ser Lys Leu Glu Tyr 
        35                  40                  45              


Ile Lys Glu Leu Gly Val Asp Ala Ile Trp Ile Ser Pro Phe Tyr Asp 
    50                  55                  60                  


Ser Pro Gln Asp Asp Met Gly Tyr Asp Ile Ala Asn Tyr Glu Lys Val 
65                  70                  75                  80  


Trp Pro Thr Tyr Gly Thr Asn Glu Asp Cys Phe Ala Leu Ile Glu Lys 
                85                  90                  95      


Thr His Lys Leu Gly Met Lys Phe Ile Thr Asp Leu Val Ile Asn His 
            100                 105                 110         


Cys Ser Ser Glu His Glu Trp Phe Lys Glu Ser Arg Ser Ser Lys Thr 
        115                 120                 125             


Asn Pro Lys Arg Asp Trp Phe Phe Trp Arg Pro Pro Lys Gly Tyr Asp 
    130                 135                 140                 


Ala Glu Gly Lys Pro Ile Pro Pro Asn Asn Trp Lys Ser Tyr Phe Gly 
145                 150                 155                 160 


Gly Ser Ala Trp Thr Phe Asp Glu Lys Thr Gln Glu Phe Tyr Leu Arg 
                165                 170                 175     


Leu Phe Cys Ser Thr Gln Pro Asp Leu Asn Trp Glu Asn Glu Asp Cys 
            180                 185                 190         


Arg Lys Ala Ile Tyr Glu Ser Ala Val Gly Tyr Trp Leu Asp His Gly 
        195                 200                 205             


Val Asp Gly Phe Arg Ile Asp Val Gly Ser Leu Tyr Ser Lys Val Val 
    210                 215                 220                 


Gly Leu Pro Asp Ala Pro Val Val Asp Lys Asn Ser Thr Trp Gln Ser 
225                 230                 235                 240 


Ser Asp Pro Tyr Thr Leu Asn Gly Pro Arg Ile His Glu Phe His Gln 
                245                 250                 255     


Glu Met Asn Gln Phe Ile Arg Asn Arg Val Lys Asp Gly Arg Glu Ile 
            260                 265                 270         


Met Thr Val Gly Glu Met Gln His Ala Ser Asp Glu Thr Lys Arg Leu 
        275                 280                 285             


Tyr Thr Ser Ala Ser Arg His Glu Leu Ser Glu Leu Phe Asn Phe Ser 
    290                 295                 300                 


His Thr Asp Val Gly Thr Ser Pro Leu Phe Arg Tyr Asn Leu Val Pro 
305                 310                 315                 320 


Phe Glu Leu Lys Asp Trp Lys Ile Ala Leu Ala Glu Leu Phe Arg Tyr 
                325                 330                 335     


Ile Asn Gly Thr Asp Cys Trp Ser Thr Ile Tyr Leu Glu Asn His Asp 
            340                 345                 350         


Gln Pro Arg Ser Ile Thr Arg Phe Gly Asp Asp Ser Pro Lys Asn Arg 
        355                 360                 365             


Val Ile Ser Gly Lys Leu Leu Ser Val Leu Leu Ser Ala Leu Thr Gly 
    370                 375                 380                 


Thr Leu Tyr Val Tyr Gln Gly Gln Glu Leu Gly Gln Ile Asn Phe Lys 
385                 390                 395                 400 


Asn Trp Pro Val Glu Lys Tyr Glu Asp Val Glu Ile Arg Asn Asn Tyr 
                405                 410                 415     


Asn Ala Ile Lys Glu Glu His Gly Glu Asn Ser Glu Glu Met Lys Lys 
            420                 425                 430         


Phe Leu Glu Ala Ile Ala Leu Ile Ser Arg Asp His Ala Arg Thr Pro 
        435                 440                 445             


Met Gln Trp Ser Arg Glu Glu Pro Asn Ala Gly Phe Ser Gly Pro Ser 
    450                 455                 460                 


Ala Lys Pro Trp Phe Tyr Leu Asn Asp Ser Phe Arg Glu Gly Ile Asn 
465                 470                 475                 480 


Val Glu Asp Glu Ile Lys Asp Pro Asn Ser Val Leu Asn Phe Trp Lys 
                485                 490                 495     


Glu Ala Leu Lys Phe Arg Lys Ala His Lys Asp Ile Thr Val Tyr Gly 
            500                 505                 510         


Tyr Asp Phe Glu Phe Ile Asp Leu Asp Asn Lys Lys Leu Phe Ser Phe 
        515                 520                 525             


Thr Lys Lys Tyr Asn Asn Lys Thr Leu Phe Ala Ala Leu Asn Phe Ser 
    530                 535                 540                 


Ser Asp Ala Thr Asp Phe Lys Ile Pro Asn Asp Asp Ser Ser Phe Lys 
545                 550                 555                 560 


Leu Glu Phe Gly Asn Tyr Pro Lys Lys Glu Val Asp Ala Ser Ser Arg 
                565                 570                 575     


Thr Leu Lys Pro Trp Glu Gly Arg Ile Tyr Ile Ser Glu 
            580                 585                 


<210>  25
<211>  589
<212>  PRT
<213>  Hybrid yeast 7

<400>  25

Met Thr Ile Ser Ser Ala His Pro Glu Thr Glu Pro Lys Trp Trp Lys 
1               5                   10                  15      


Glu Ala Thr Phe Tyr Gln Ile Tyr Pro Ala Ser Phe Lys Asp Ser Asn 
            20                  25                  30          


Asp Asp Gly Trp Gly Asp Met Lys Gly Ile Ser Ser Lys Leu Glu Tyr 
        35                  40                  45              


Ile Lys Glu Leu Gly Val Asp Ala Ile Trp Ile Ser Pro Phe Tyr Asp 
    50                  55                  60                  


Ser Pro Gln Asp Asp Met Gly Tyr Asp Ile Ala Asn Tyr Glu Lys Val 
65                  70                  75                  80  


Trp Pro Thr Tyr Gly Thr Asn Glu Asp Cys Phe Ala Leu Ile Glu Lys 
                85                  90                  95      


Thr His Lys Leu Gly Met Lys Phe Ile Thr Asp Leu Val Ile Asn His 
            100                 105                 110         


Cys Ser Ser Glu His Glu Trp Phe Lys Glu Ser Arg Ser Ser Lys Thr 
        115                 120                 125             


Asn Pro Lys Arg Asp Trp Phe Phe Trp Arg Pro Pro Lys Gly Tyr Asp 
    130                 135                 140                 


Ala Glu Gly Lys Pro Ile Pro Pro Asn Asn Trp Lys Ser Tyr Phe Gly 
145                 150                 155                 160 


Gly Ser Ala Trp Ile Phe Asp Glu Lys Thr Gln Glu Phe Tyr Leu Arg 
                165                 170                 175     


Leu Phe Cys Ser Thr Gln Pro Asp Leu Asn Trp Glu Asn Glu Asp Cys 
            180                 185                 190         


Arg Lys Ala Ile Tyr Glu Ser Ala Val Gly Tyr Trp Leu Asp His Gly 
        195                 200                 205             


Val Asp Gly Phe Arg Ile Asp Val Gly Ser Leu Tyr Ser Lys Val Val 
    210                 215                 220                 


Gly Leu Pro Asp Ala Pro Val Val Asp Lys Asn Ser Thr Trp Gln Ser 
225                 230                 235                 240 


Ser Asp Pro Tyr Thr Leu Asn Gly Pro Arg Ile His Glu Phe His Gln 
                245                 250                 255     


Glu Met Asn Gln Phe Ile Arg Asn Arg Val Lys Asp Gly Arg Glu Ile 
            260                 265                 270         


Met Thr Val Gly Glu Met Gln His Ala Ser Asp Glu Thr Lys Arg Leu 
        275                 280                 285             


Tyr Thr Ser Ala Ser Arg His Glu Leu Ser Glu Leu Phe Asn Phe Ser 
    290                 295                 300                 


His Thr Asp Val Gly Thr Ser Pro Leu Phe Arg Tyr Asn Leu Val Pro 
305                 310                 315                 320 


Phe Glu Leu Lys Asp Trp Lys Ile Ala Leu Ala Glu Leu Phe Arg Tyr 
                325                 330                 335     


Ile Asn Gly Thr Asp Cys Trp Ser Thr Ile Tyr Leu Glu Asn His Asp 
            340                 345                 350         


Gln Pro Arg Ser Ile Thr Arg Phe Gly Asp Asp Ser Pro Lys Asn Arg 
        355                 360                 365             


Val Ile Ser Gly Lys Leu Leu Ser Val Leu Leu Ser Ala Leu Thr Gly 
    370                 375                 380                 


Thr Leu Tyr Val Tyr Gln Gly Gln Glu Leu Gly Gln Ile Asn Phe Lys 
385                 390                 395                 400 


Asn Trp Pro Val Glu Lys Tyr Glu Asp Val Glu Ile Arg Asn Asn Tyr 
                405                 410                 415     


Asn Ala Ile Lys Glu Glu His Gly Glu Asn Ser Glu Glu Met Lys Lys 
            420                 425                 430         


Phe Leu Glu Ala Ile Ala Leu Ile Ser Arg Asp His Ala Arg Thr Pro 
        435                 440                 445             


Met Gln Trp Ser Arg Glu Glu Pro Asn Ala Gly Phe Ser Gly Pro Ser 
    450                 455                 460                 


Ala Lys Pro Trp Phe Tyr Leu Asn Asp Ser Phe Arg Glu Gly Ile Asn 
465                 470                 475                 480 


Val Glu Asp Glu Ile Lys Asp Pro Asn Ser Val Leu Asn Phe Trp Lys 
                485                 490                 495     


Glu Ala Leu Lys Phe Arg Lys Ala His Lys Asp Ile Thr Val Tyr Gly 
            500                 505                 510         


Tyr Asp Phe Glu Phe Ile Asp Leu Asp Asn Lys Lys Leu Phe Ser Phe 
        515                 520                 525             


Thr Lys Lys Tyr Asn Asn Lys Thr Leu Phe Ala Ala Leu Asn Phe Ser 
    530                 535                 540                 


Ser Asp Ala Thr Asp Phe Lys Ile Pro Asn Asp Asp Ser Ser Phe Lys 
545                 550                 555                 560 


Leu Glu Phe Gly Asn Tyr Pro Lys Lys Glu Val Asp Ala Ser Ser Arg 
                565                 570                 575     


Thr Leu Lys Pro Trp Glu Gly Arg Ile Tyr Ile Ser Glu 
            580                 585                 


<210>  26
<211>  394
<212>  PRT
<213>  Hybrid yeast 4

<400>  26

Met Lys Asn Ile Ile Ser Leu Val Ser Lys Lys Lys Ala Ala Ser Lys 
1               5                   10                  15      


Asn Glu Asp Lys Asn Ile Ser Glu Ser Ser Arg Asp Ile Val Asn Gln 
            20                  25                  30          


Gln Glu Val Phe Asn Thr Glu Asn Phe Glu Glu Gly Lys Lys Asp Ser 
        35                  40                  45              


Ala Phe Glu Leu Asp His Leu Glu Phe Thr Thr Asn Ser Ala Gln Leu 
    50                  55                  60                  


Gly Asp Ser Asp Glu Asp Asn Glu Asn Met Ile Asn Glu Met Asn Ala 
65                  70                  75                  80  


Thr Asp Glu Ala Asn Glu Ala Asn Ser Glu Glu Lys Ser Met Thr Leu 
                85                  90                  95      


Lys Gln Ala Leu Leu Lys Tyr Pro Lys Ala Ala Leu Trp Ser Ile Leu 
            100                 105                 110         


Val Ser Thr Thr Leu Val Met Glu Gly Tyr Asp Thr Ala Leu Leu Asn 
        115                 120                 125             


Ala Leu Tyr Ala Leu Pro Val Phe Gln Arg Lys Phe Gly Thr Leu Asn 
    130                 135                 140                 


Gly Glu Gly Ser Tyr Glu Ile Thr Ser Gln Trp Gln Ile Gly Leu Asn 
145                 150                 155                 160 


Met Cys Val Gln Cys Gly Glu Met Ile Gly Leu Gln Ile Thr Thr Tyr 
                165                 170                 175     


Met Val Glu Phe Met Gly Asn Arg Tyr Thr Met Ile Thr Ala Leu Gly 
            180                 185                 190         


Leu Leu Thr Ala Tyr Ile Phe Ile Leu Tyr Tyr Cys Lys Ser Leu Ala 
        195                 200                 205             


Met Ile Ala Val Gly Gln Val Leu Ser Ala Met Pro Trp Gly Cys Phe 
    210                 215                 220                 


Gln Gly Leu Thr Val Thr Tyr Ala Ser Glu Val Cys Pro Leu Ala Leu 
225                 230                 235                 240 


Arg Tyr Tyr Met Thr Ser Tyr Ser Asn Ile Cys Trp Leu Phe Gly Gln 
                245                 250                 255     


Ile Phe Ala Ser Gly Ile Met Lys Asn Ser Gln Glu Asn Leu Gly Asn 
            260                 265                 270         


Ser Asp Leu Asp Tyr Lys Leu Pro Phe Ala Leu Gln Trp Ile Trp Pro 
        275                 280                 285             


Ala Pro Leu Met Ile Gly Ile Phe Phe Ala Pro Glu Ser Pro Trp Trp 
    290                 295                 300                 


Leu Val Arg Lys Asp Arg Val Ala Glu Ala Arg Lys Ser Leu Ser Arg 
305                 310                 315                 320 


Ile Leu Ser Gly Lys Gly Ala Glu Lys Asp Ile Gln Val Asp Leu Thr 
                325                 330                 335     


Leu Lys Gln Ile Glu Leu Thr Ile Glu Lys Glu Arg Leu Leu Ala Ser 
            340                 345                 350         


Lys Ser Gly Ser Phe Phe Asp Cys Phe Lys Gly Val Asn Gly Arg Arg 
        355                 360                 365             


Thr Arg Leu Ala Cys Leu Ala Trp Val Ala Gln Asn Thr Ser Gly Ala 
    370                 375                 380                 


Cys Leu Leu Gly Tyr Ser Thr Tyr Phe Phe 
385                 390                 


<210>  27
<211>  610
<212>  PRT
<213>  Hybrid yeast 4

<400>  27

Met Lys Asn Ile Leu Ser Leu Val Gly Arg Lys Glu Asn Thr Pro Glu 
1               5                   10                  15      


Asp Val Thr Ala Asn Leu Ala Asp Thr Ser Ser Thr Thr Val Met Gln 
            20                  25                  30          


Ala Lys Asp Leu Val Ile Glu Asp Phe Glu Glu Arg Lys Lys Asn Asp 
        35                  40                  45              


Ala Phe Glu Leu Asn His Leu Glu Leu Thr Thr Asn Ala Thr Gln Leu 
    50                  55                  60                  


Ser Asp Ser Asp Glu Asp Lys Glu Asn Val Ile Arg Val Ala Glu Ala 
65                  70                  75                  80  


Thr Asp Asp Ala Asn Glu Ala Asn Asn Glu Glu Lys Ser Met Thr Leu 
                85                  90                  95      


Arg Gln Ala Leu Arg Lys Tyr Pro Lys Ala Ala Leu Trp Ser Ile Leu 
            100                 105                 110         


Val Ser Thr Thr Leu Val Met Glu Gly Tyr Asp Thr Ala Leu Leu Ser 
        115                 120                 125             


Ala Leu Tyr Ala Leu Pro Val Phe Gln Arg Lys Phe Gly Thr Met Asn 
    130                 135                 140                 


Ala Glu Gly Ser Tyr Glu Ile Thr Ser Gln Trp Gln Ile Gly Leu Asn 
145                 150                 155                 160 


Met Cys Val Leu Cys Gly Glu Met Ile Gly Leu Gln Ile Thr Thr Tyr 
                165                 170                 175     


Met Val Glu Phe Met Gly Asn Arg Tyr Thr Met Ile Thr Ala Leu Ser 
            180                 185                 190         


Leu Leu Thr Ala Tyr Ile Phe Ile Leu Tyr Tyr Cys Lys Ser Leu Ala 
        195                 200                 205             


Met Ile Ala Val Gly Gln Ile Leu Ser Ala Met Pro Trp Gly Cys Phe 
    210                 215                 220                 


Gln Ser Leu Ala Val Thr Tyr Ala Ser Glu Val Cys Pro Leu Ala Leu 
225                 230                 235                 240 


Arg Tyr Tyr Met Thr Ser Tyr Ser Asn Ile Cys Trp Leu Phe Gly Gln 
                245                 250                 255     


Ile Phe Ala Ser Gly Ile Met Lys Asn Ser Gln Glu Asn Leu Gly Asn 
            260                 265                 270         


Ser Asp Leu Gly Tyr Lys Leu Pro Phe Ala Leu Gln Trp Ile Trp Pro 
        275                 280                 285             


Ala Pro Leu Ile Ile Gly Ile Phe Phe Ala Pro Glu Ser Pro Trp Trp 
    290                 295                 300                 


Leu Val Arg Lys Asn Lys Ile Val Glu Ala Lys Lys Ser Leu Asn Arg 
305                 310                 315                 320 


Ile Leu Ser Gly Thr Val Thr Glu Lys Glu Ile Gln Val Asp Ile Thr 
                325                 330                 335     


Leu Lys Gln Ile Glu Met Thr Ile Glu Lys Glu Arg Leu Arg Ala Ser 
            340                 345                 350         


Lys Ser Gly Ser Phe Phe Ser Cys Phe Lys Gly Val Asp Gly Arg Arg 
        355                 360                 365             


Thr Arg Leu Ala Cys Leu Thr Trp Val Ala Gln Asn Ser Ser Gly Ala 
    370                 375                 380                 


Val Leu Leu Gly Tyr Ser Thr Tyr Phe Phe Glu Arg Ala Gly Met Ala 
385                 390                 395                 400 


Thr Asp Lys Ala Phe Thr Phe Ser Leu Ile Gln Tyr Cys Leu Gly Leu 
                405                 410                 415     


Ala Gly Thr Leu Gly Ser Trp Val Ile Ser Gly Arg Val Gly Arg Trp 
            420                 425                 430         


Thr Ile Leu Thr Tyr Gly Leu Ser Phe Gln Met Val Cys Leu Phe Ile 
        435                 440                 445             


Ile Gly Gly Met Gly Phe Ala Ser Gly Ser Ser Ala Ser Asn Ala Ala 
    450                 455                 460                 


Gly Gly Leu Leu Leu Ala Leu Ser Phe Phe Tyr Asn Ala Gly Ile Gly 
465                 470                 475                 480 


Ala Val Val Tyr Cys Ile Val Ala Glu Ile Pro Ser Ala Glu Leu Arg 
                485                 490                 495     


Thr Lys Thr Ile Val Leu Ala Arg Ile Cys Tyr Asn Leu Met Ala Val 
            500                 505                 510         


Phe Asn Ala Ile Leu Thr Pro Tyr Met Leu Asn Val Ser Asp Trp Asn 
        515                 520                 525             


Trp Gly Ala Lys Thr Gly Leu Tyr Trp Gly Asp Phe Thr Ala Leu Thr 
    530                 535                 540                 


Leu Ala Trp Val Ile Ile Asp Leu Pro Glu Thr Thr Gly Arg Thr Phe 
545                 550                 555                 560 


Ser Glu Ile Asn Glu Leu Phe Ser Gln Gly Val Pro Ala Arg Lys Phe 
                565                 570                 575     


Ala Ser Thr Val Val Asp Pro Phe Gly Lys Arg Gly Leu Gln Asn Arg 
            580                 585                 590         


Pro Gln Val Asp Asn Ile Ile Asp Arg Phe Ser Ser Ala Ser Gln Gln 
        595                 600                 605             


Ala Leu 
    610 


<210>  28
<211>  610
<212>  PRT
<213>  Hybrid yeast 4

<400>  28

Met Lys Asn Ile Leu Ser Leu Val Gly Arg Lys Glu Asn Thr Pro Glu 
1               5                   10                  15      


Asp Val Thr Ala Asn Leu Ala Asp Thr Ser Ser Thr Thr Val Met Gln 
            20                  25                  30          


Ala Lys Asp Leu Val Ile Glu Asp Phe Glu Glu Arg Lys Lys Asn Asp 
        35                  40                  45              


Ala Phe Glu Leu Asn His Leu Glu Leu Thr Thr Asn Ala Thr Gln Leu 
    50                  55                  60                  


Ser Asp Ser Asp Glu Asp Lys Glu Asn Val Ile Arg Val Ala Glu Ala 
65                  70                  75                  80  


Thr Asp Asp Ala Asn Glu Ala Asn Asn Glu Glu Lys Ser Met Thr Leu 
                85                  90                  95      


Arg Gln Ala Leu Arg Lys Tyr Pro Lys Ala Ala Leu Trp Ser Ile Leu 
            100                 105                 110         


Val Ser Thr Thr Leu Val Met Glu Gly Tyr Asp Thr Ala Leu Leu Ser 
        115                 120                 125             


Ala Leu Tyr Ala Leu Pro Val Phe Gln Arg Lys Phe Gly Thr Met Asn 
    130                 135                 140                 


Ala Glu Gly Ser Tyr Glu Ile Thr Ser Gln Trp Gln Ile Gly Leu Asn 
145                 150                 155                 160 


Met Cys Val Leu Cys Gly Glu Met Ile Gly Leu Gln Ile Thr Thr Tyr 
                165                 170                 175     


Met Val Glu Phe Met Gly Asn Arg Tyr Thr Met Ile Thr Ala Leu Ser 
            180                 185                 190         


Leu Leu Thr Ala Tyr Ile Phe Ile Leu Tyr Tyr Cys Lys Ser Leu Ala 
        195                 200                 205             


Met Ile Ala Val Gly Gln Ile Leu Ser Ala Met Pro Trp Gly Cys Phe 
    210                 215                 220                 


Gln Ser Leu Ala Val Thr Tyr Ala Ser Glu Val Cys Pro Leu Ala Leu 
225                 230                 235                 240 


Arg Tyr Tyr Met Thr Ser Tyr Ser Asn Ile Cys Trp Leu Phe Gly Gln 
                245                 250                 255     


Ile Phe Ala Ser Gly Ile Met Lys Asn Ser Gln Glu Asn Leu Gly Asn 
            260                 265                 270         


Ser Asp Leu Gly Tyr Lys Leu Pro Phe Ala Leu Gln Trp Ile Trp Pro 
        275                 280                 285             


Ala Pro Leu Ile Ile Gly Ile Phe Phe Ala Pro Glu Ser Pro Trp Trp 
    290                 295                 300                 


Leu Val Arg Lys Asn Lys Ile Val Glu Ala Lys Lys Ser Leu Asn Arg 
305                 310                 315                 320 


Ile Leu Ser Gly Thr Val Thr Glu Lys Glu Ile Gln Val Asp Ile Thr 
                325                 330                 335     


Leu Lys Gln Ile Glu Met Thr Ile Glu Lys Glu Arg Leu Arg Ala Ser 
            340                 345                 350         


Lys Ser Gly Ser Phe Phe Ser Cys Phe Lys Gly Val Asp Gly Arg Arg 
        355                 360                 365             


Thr Arg Leu Ala Cys Leu Thr Trp Val Ala Gln Asn Ser Ser Gly Ala 
    370                 375                 380                 


Val Leu Leu Gly Tyr Ser Thr Tyr Phe Phe Glu Arg Ala Gly Met Ala 
385                 390                 395                 400 


Thr Asp Lys Ala Phe Thr Phe Ser Leu Ile Gln Tyr Cys Leu Gly Leu 
                405                 410                 415     


Ala Gly Thr Leu Gly Ser Trp Val Ile Ser Gly Arg Val Gly Arg Trp 
            420                 425                 430         


Thr Ile Leu Thr Tyr Gly Leu Ser Phe Gln Met Val Cys Leu Phe Ile 
        435                 440                 445             


Ile Gly Gly Met Gly Phe Ala Ser Gly Ser Ser Ala Ser Asn Ala Ala 
    450                 455                 460                 


Gly Gly Leu Leu Leu Ala Leu Ser Phe Phe Tyr Asn Ala Gly Ile Gly 
465                 470                 475                 480 


Ala Val Val Tyr Cys Ile Val Ala Glu Ile Pro Ser Ala Glu Leu Arg 
                485                 490                 495     


Thr Lys Thr Ile Val Leu Ala Arg Ile Cys Tyr Asn Leu Met Ala Val 
            500                 505                 510         


Phe Asn Ala Ile Leu Thr Pro Tyr Met Leu Asn Val Ser Asp Trp Asn 
        515                 520                 525             


Trp Gly Ala Lys Thr Gly Leu Tyr Trp Gly Gly Phe Thr Ala Leu Thr 
    530                 535                 540                 


Leu Ala Trp Val Ile Ile Asp Leu Pro Glu Thr Thr Gly Arg Thr Phe 
545                 550                 555                 560 


Ser Glu Ile Asn Glu Leu Phe Ser Gln Gly Val Pro Ala Arg Lys Phe 
                565                 570                 575     


Ala Ser Thr Val Val Asp Pro Phe Gly Lys Arg Gly Leu Gln Asn Arg 
            580                 585                 590         


Pro Gln Val Asp Asn Ile Ile Asp Arg Phe Ser Ser Ala Ser Gln Gln 
        595                 600                 605             


Ala Leu 
    610 


<210>  29
<211>  394
<212>  PRT
<213>  Hybrid yeast 7

<400>  29

Met Lys Asn Ile Ile Ser Leu Val Ser Lys Lys Lys Ala Ala Ser Lys 
1               5                   10                  15      


Asn Glu Asp Lys Asn Ile Ser Glu Ser Ser Arg Asp Ile Val Asn Gln 
            20                  25                  30          


Gln Glu Val Phe Asn Thr Glu Asn Phe Glu Glu Gly Lys Lys Asp Ser 
        35                  40                  45              


Ala Phe Glu Leu Asp His Leu Glu Phe Thr Thr Asn Ser Ala Gln Leu 
    50                  55                  60                  


Gly Asp Ser Asp Glu Asp Asn Glu Asn Met Ile Asn Glu Met Asn Ala 
65                  70                  75                  80  


Thr Asp Glu Ala Asn Glu Ala Asn Ser Glu Glu Lys Ser Met Thr Leu 
                85                  90                  95      


Lys Gln Ala Leu Leu Lys Tyr Pro Lys Ala Ala Leu Trp Ser Ile Leu 
            100                 105                 110         


Val Ser Thr Thr Leu Val Met Glu Gly Tyr Asp Thr Ala Leu Leu Asn 
        115                 120                 125             


Ala Leu Tyr Ala Leu Pro Val Phe Gln Arg Lys Phe Gly Thr Leu Asn 
    130                 135                 140                 


Gly Glu Gly Ser Tyr Glu Ile Thr Ser Gln Trp Gln Ile Gly Leu Asn 
145                 150                 155                 160 


Met Cys Val Gln Cys Gly Glu Met Ile Gly Leu Gln Ile Thr Thr Tyr 
                165                 170                 175     


Met Val Glu Phe Met Gly Asn Arg Tyr Thr Met Ile Thr Ala Leu Gly 
            180                 185                 190         


Leu Leu Thr Ala Tyr Ile Phe Ile Leu Tyr Tyr Cys Lys Ser Leu Ala 
        195                 200                 205             


Met Ile Ala Val Gly Gln Val Leu Ser Ala Met Pro Trp Gly Cys Phe 
    210                 215                 220                 


Gln Gly Leu Thr Val Thr Tyr Ala Ser Glu Val Cys Pro Leu Ala Leu 
225                 230                 235                 240 


Arg Tyr Tyr Met Thr Ser Tyr Ser Asn Ile Cys Trp Leu Phe Gly Gln 
                245                 250                 255     


Ile Phe Ala Ser Gly Ile Met Lys Asn Ser Gln Glu Asn Leu Gly Asn 
            260                 265                 270         


Ser Asp Leu Asp Tyr Lys Leu Pro Phe Ala Leu Gln Trp Ile Trp Pro 
        275                 280                 285             


Ala Pro Leu Met Ile Gly Ile Phe Phe Ala Pro Glu Ser Pro Trp Trp 
    290                 295                 300                 


Leu Val Arg Lys Asp Arg Val Ala Glu Ala Arg Lys Ser Leu Ser Arg 
305                 310                 315                 320 


Ile Leu Ser Gly Lys Gly Ala Glu Lys Asp Ile Gln Val Asp Leu Thr 
                325                 330                 335     


Leu Lys Gln Ile Glu Leu Thr Ile Glu Lys Glu Arg Leu Leu Ala Ser 
            340                 345                 350         


Lys Ser Gly Ser Phe Phe Asp Cys Phe Lys Gly Val Asn Gly Arg Arg 
        355                 360                 365             


Thr Arg Leu Ala Cys Leu Ala Trp Val Ala Gln Asn Thr Ser Gly Ala 
    370                 375                 380                 


Cys Leu Leu Gly Tyr Ser Thr Tyr Phe Phe 
385                 390                 


<210>  30
<211>  616
<212>  PRT
<213>  Hybrid yeast 7

<400>  30

Met Lys Asn Ile Ile Ser Leu Val Ser Lys Lys Lys Ala Ala Ser Lys 
1               5                   10                  15      


Asn Glu Asp Lys Asn Ile Ser Glu Ser Ser Arg Asp Ile Val Asn Gln 
            20                  25                  30          


Gln Glu Val Phe Asn Thr Glu Asn Phe Glu Glu Gly Arg Lys Asp Ser 
        35                  40                  45              


Ala Phe Glu Leu Asp His Leu Glu Phe Thr Ile Asn Ser Ala Gln Leu 
    50                  55                  60                  


Gly Asp Ser Asp Glu Asp Asn Glu Asn Val Ile Asn Glu Thr Asn Thr 
65                  70                  75                  80  


Thr Asp Asp Ala Asn Glu Ala Asn Ser Glu Glu Lys Ser Met Thr Leu 
                85                  90                  95      


Lys Gln Ala Leu Leu Ile Tyr Pro Lys Ala Ala Leu Trp Ser Ile Leu 
            100                 105                 110         


Val Ser Thr Thr Leu Val Met Glu Gly Tyr Asp Thr Ala Leu Leu Asn 
        115                 120                 125             


Ala Leu Tyr Ala Leu Pro Val Phe Gln Arg Lys Phe Gly Thr Leu Asn 
    130                 135                 140                 


Gly Glu Gly Ser Tyr Glu Ile Thr Ser Gln Trp Gln Ile Gly Leu Asn 
145                 150                 155                 160 


Met Cys Val Gln Cys Gly Glu Ile Ile Gly Leu Gln Ile Thr Pro Tyr 
                165                 170                 175     


Met Val Glu Phe Met Gly Asn Arg Tyr Thr Met Ile Thr Ala Leu Gly 
            180                 185                 190         


Leu Leu Thr Ala Tyr Val Phe Ile Leu Tyr Tyr Cys Lys Ser Leu Ala 
        195                 200                 205             


Met Ile Ala Val Gly Gln Val Leu Ser Ala Met Pro Trp Gly Cys Phe 
    210                 215                 220                 


Gln Gly Leu Thr Val Thr Tyr Ala Ser Glu Val Cys Pro Leu Ala Leu 
225                 230                 235                 240 


Arg Tyr Tyr Met Thr Ser Tyr Ser Asn Ile Cys Trp Leu Phe Gly Gln 
                245                 250                 255     


Ile Phe Ala Ser Gly Ile Met Lys Asn Ser Gln Glu Asn Leu Gly Asn 
            260                 265                 270         


Ser Asp Leu Gly Tyr Lys Leu Pro Phe Ala Leu Gln Trp Ile Trp Pro 
        275                 280                 285             


Ala Pro Leu Met Ile Gly Ile Phe Phe Ala Pro Glu Ser Pro Trp Trp 
    290                 295                 300                 


Leu Val Arg Lys Asp Arg Val Ala Glu Ala Arg Lys Ser Leu Ser Arg 
305                 310                 315                 320 


Ile Leu Ser Gly Lys Gly Ala Glu Lys Asp Ile Gln Ile Asp Leu Thr 
                325                 330                 335     


Leu Lys Gln Ile Glu Leu Thr Ile Glu Lys Glu Arg Leu Leu Ala Ser 
            340                 345                 350         


Lys Ser Gly Ser Phe Phe Asp Cys Phe Lys Gly Val Asn Gly Arg Arg 
        355                 360                 365             


Thr Arg Leu Ala Cys Leu Thr Trp Val Ala Gln Asn Thr Ser Gly Ala 
    370                 375                 380                 


Cys Leu Leu Gly Tyr Ser Thr Tyr Phe Phe Glu Arg Ala Gly Met Ala 
385                 390                 395                 400 


Thr Asp Lys Ala Phe Thr Phe Ser Val Ile Gln Tyr Cys Leu Gly Leu 
                405                 410                 415     


Ala Gly Thr Leu Cys Ser Trp Val Ile Ser Gly Arg Val Gly Arg Trp 
            420                 425                 430         


Thr Ile Leu Thr Tyr Gly Leu Ala Phe Gln Met Val Cys Leu Phe Ile 
        435                 440                 445             


Ile Gly Gly Met Gly Phe Gly Ser Gly Ser Gly Ala Ser Asn Gly Ala 
    450                 455                 460                 


Gly Gly Leu Leu Leu Ala Leu Ser Phe Phe Tyr Asn Ala Gly Ile Gly 
465                 470                 475                 480 


Ala Val Val Tyr Cys Ile Val Thr Glu Ile Pro Ser Ala Glu Leu Arg 
                485                 490                 495     


Thr Lys Thr Ile Val Leu Ala Arg Ile Cys Tyr Asn Ile Met Ala Val 
            500                 505                 510         


Ile Asn Ala Ile Leu Thr Pro Tyr Met Leu Asn Val Ser Asp Trp Asn 
        515                 520                 525             


Trp Gly Ala Lys Thr Gly Leu Tyr Trp Gly Gly Phe Thr Ala Val Thr 
    530                 535                 540                 


Leu Ala Trp Val Ile Ile Asp Leu Pro Glu Thr Ser Gly Arg Thr Phe 
545                 550                 555                 560 


Ser Glu Ile Asn Glu Leu Phe Asn Gln Gly Val Pro Ala Arg Lys Phe 
                565                 570                 575     


Ala Ser Thr Val Val Asp Pro Phe Gly Lys Gly Lys Thr Gln His Asp 
            580                 585                 590         


Ser Leu Asp Asp Glu Ser Ile Ser Gln Ser Ser Ser Ile Lys Gln Arg 
        595                 600                 605             


Glu Leu Asn Ala Ala Asp Lys Cys 
    610                 615     


<210>  31
<211>  610
<212>  PRT
<213>  Hybrid yeast 7

<400>  31

Met Lys Asn Ile Leu Ser Leu Val Gly Arg Lys Glu Asn Thr Pro Glu 
1               5                   10                  15      


Asp Val Thr Ala Asn Leu Ala Asp Thr Ser Ser Thr Thr Val Met Gln 
            20                  25                  30          


Ala Lys Asp Leu Val Ile Glu Asp Phe Glu Glu Arg Lys Lys Asn Asp 
        35                  40                  45              


Ala Phe Glu Leu Asn His Leu Glu Leu Thr Thr Asn Ala Thr Gln Leu 
    50                  55                  60                  


Ser Asp Ser Asp Glu Asp Lys Glu Asn Val Ile Arg Val Ala Glu Ala 
65                  70                  75                  80  


Thr Asp Asp Ala Asn Glu Ala Asn Asn Glu Glu Lys Ser Met Thr Leu 
                85                  90                  95      


Arg Gln Ala Leu Arg Lys Tyr Pro Lys Ala Ala Leu Trp Ser Ile Leu 
            100                 105                 110         


Val Ser Thr Thr Leu Val Met Glu Gly Tyr Asp Thr Ala Leu Leu Ser 
        115                 120                 125             


Ala Leu Tyr Ala Leu Pro Val Phe Gln Arg Lys Phe Gly Thr Met Asn 
    130                 135                 140                 


Ala Glu Gly Ser Tyr Glu Ile Thr Ser Gln Trp Gln Ile Gly Leu Asn 
145                 150                 155                 160 


Met Cys Val Leu Cys Gly Glu Met Ile Gly Leu Gln Ile Thr Thr Tyr 
                165                 170                 175     


Met Val Glu Phe Met Gly Asn Arg Tyr Thr Met Ile Thr Ala Leu Ser 
            180                 185                 190         


Leu Leu Thr Ala Tyr Ile Phe Ile Leu Tyr Tyr Cys Lys Ser Leu Ala 
        195                 200                 205             


Met Ile Ala Val Gly Gln Ile Leu Ser Ala Met Pro Trp Gly Cys Phe 
    210                 215                 220                 


Gln Ser Leu Ala Val Thr Tyr Ala Ser Glu Val Cys Pro Leu Ala Leu 
225                 230                 235                 240 


Arg Tyr Tyr Met Thr Ser Tyr Ser Asn Ile Cys Trp Leu Phe Gly Gln 
                245                 250                 255     


Ile Phe Ala Ser Gly Ile Met Lys Asn Ser Gln Glu Asn Leu Gly Asn 
            260                 265                 270         


Ser Asp Leu Gly Tyr Lys Leu Pro Phe Ala Leu Gln Trp Ile Trp Pro 
        275                 280                 285             


Ala Pro Leu Ile Ile Gly Ile Phe Phe Ala Pro Glu Ser Pro Trp Trp 
    290                 295                 300                 


Leu Val Arg Lys Asn Lys Ile Val Glu Ala Lys Lys Ser Leu Asn Arg 
305                 310                 315                 320 


Ile Leu Ser Gly Thr Val Thr Glu Lys Glu Ile Gln Val Asp Ile Thr 
                325                 330                 335     


Leu Lys Gln Ile Glu Met Thr Ile Glu Lys Glu Arg Leu Arg Ala Ser 
            340                 345                 350         


Lys Ser Gly Ser Phe Phe Ser Cys Phe Lys Gly Val Asp Gly Arg Arg 
        355                 360                 365             


Thr Arg Leu Ala Cys Leu Thr Trp Val Ala Gln Asn Ser Ser Gly Ala 
    370                 375                 380                 


Val Leu Leu Gly Tyr Ser Thr Tyr Phe Phe Glu Arg Ala Gly Met Ala 
385                 390                 395                 400 


Thr Asp Lys Ala Phe Thr Phe Ser Leu Ile Gln Tyr Cys Leu Gly Leu 
                405                 410                 415     


Ala Gly Thr Leu Gly Ser Trp Val Ile Ser Gly Arg Val Gly Arg Trp 
            420                 425                 430         


Thr Ile Leu Thr Tyr Gly Leu Ser Phe Gln Met Val Cys Leu Phe Ile 
        435                 440                 445             


Ile Gly Gly Met Gly Phe Ala Ser Gly Ser Ser Ala Ser Asn Ala Ala 
    450                 455                 460                 


Gly Gly Leu Leu Leu Ala Leu Ser Phe Phe Tyr Asn Ala Gly Ile Gly 
465                 470                 475                 480 


Ala Val Val Tyr Cys Ile Val Ala Glu Ile Pro Ser Ala Glu Leu Arg 
                485                 490                 495     


Thr Lys Thr Ile Val Leu Ala Arg Ile Cys Tyr Asn Leu Met Ala Val 
            500                 505                 510         


Phe Asn Ala Ile Leu Thr Pro Tyr Met Leu Asn Val Ser Asp Trp Asn 
        515                 520                 525             


Trp Gly Ala Lys Thr Gly Leu Tyr Trp Gly Gly Phe Thr Ala Leu Thr 
    530                 535                 540                 


Leu Ala Trp Val Ile Ile Asp Leu Pro Glu Thr Thr Gly Arg Thr Phe 
545                 550                 555                 560 


Ser Glu Ile Asn Glu Leu Phe Ser Gln Gly Val Pro Ala Arg Lys Phe 
                565                 570                 575     


Ala Ser Thr Val Val Asp Pro Phe Gly Lys Arg Gly Leu Gln Asn Arg 
            580                 585                 590         


Pro Gln Val Asp Asn Ile Ile Asp Arg Phe Ser Ser Ala Ser Gln Gln 
        595                 600                 605             


Ala Leu 
    610 


<210>  32
<211>  610
<212>  PRT
<213>  Hybrid yeast 7

<400>  32

Met Lys Asn Ile Leu Ser Leu Val Gly Arg Lys Glu Asn Thr Pro Glu 
1               5                   10                  15      


Asp Val Thr Ala Asn Leu Ala Asp Thr Ser Ser Thr Thr Val Met Gln 
            20                  25                  30          


Ala Lys Asp Leu Val Ile Glu Asp Phe Glu Glu Arg Lys Lys Asn Asp 
        35                  40                  45              


Ala Phe Glu Leu Asn His Leu Glu Leu Thr Thr Asn Ala Thr Gln Leu 
    50                  55                  60                  


Ser Asp Ser Asp Glu Asp Lys Glu Asn Val Ile Arg Val Ala Glu Ala 
65                  70                  75                  80  


Thr Asp Asp Ala Asn Glu Ala Asn Asn Glu Glu Lys Ser Met Thr Leu 
                85                  90                  95      


Arg Gln Ala Leu Arg Lys Tyr Pro Lys Ala Ala Leu Trp Ser Ile Leu 
            100                 105                 110         


Val Ser Thr Thr Leu Val Met Glu Gly Tyr Asp Thr Ala Leu Leu Ser 
        115                 120                 125             


Ala Leu Tyr Ala Leu Pro Val Phe Gln Arg Lys Phe Gly Thr Met Asn 
    130                 135                 140                 


Ala Glu Gly Ser Tyr Glu Ile Thr Ser Gln Trp Gln Ile Gly Leu Asn 
145                 150                 155                 160 


Met Cys Val Leu Cys Gly Glu Met Ile Gly Leu Gln Ile Thr Thr Tyr 
                165                 170                 175     


Met Val Glu Phe Met Gly Asn Arg Tyr Thr Met Ile Thr Ala Leu Ser 
            180                 185                 190         


Leu Leu Thr Ala Tyr Ile Phe Ile Leu Tyr Tyr Cys Lys Ser Leu Ala 
        195                 200                 205             


Met Ile Ala Val Gly Gln Ile Leu Ser Ala Met Pro Trp Gly Cys Phe 
    210                 215                 220                 


Gln Ser Leu Ala Val Thr Tyr Ala Ser Glu Val Cys Pro Leu Ala Leu 
225                 230                 235                 240 


Arg Tyr Tyr Met Thr Ser Tyr Ser Asn Ile Cys Trp Leu Phe Gly Gln 
                245                 250                 255     


Ile Phe Ala Ser Gly Ile Met Lys Asn Ser Gln Glu Asn Leu Gly Asn 
            260                 265                 270         


Ser Asp Leu Gly Tyr Lys Leu Pro Phe Ala Leu Gln Trp Ile Trp Pro 
        275                 280                 285             


Ala Pro Leu Ile Ile Gly Ile Phe Phe Ala Pro Glu Ser Pro Trp Trp 
    290                 295                 300                 


Leu Val Arg Lys Asn Lys Ile Val Glu Ala Lys Lys Ser Leu Asn Arg 
305                 310                 315                 320 


Ile Leu Ser Gly Thr Val Thr Glu Lys Glu Ile Gln Val Asp Ile Thr 
                325                 330                 335     


Leu Lys Gln Ile Glu Met Thr Ile Glu Lys Glu Arg Leu Arg Ala Ser 
            340                 345                 350         


Lys Ser Gly Ser Phe Phe Ser Cys Phe Lys Gly Val Asp Gly Arg Arg 
        355                 360                 365             


Thr Arg Leu Ala Cys Leu Thr Trp Val Ala Gln Asn Ser Ser Gly Ala 
    370                 375                 380                 


Val Leu Leu Gly Tyr Ser Thr Tyr Phe Phe Glu Arg Ala Gly Met Ala 
385                 390                 395                 400 


Thr Asp Lys Ala Phe Thr Phe Ser Leu Ile Gln Tyr Cys Leu Gly Leu 
                405                 410                 415     


Ala Gly Thr Leu Gly Ser Trp Val Ile Ser Gly Arg Val Gly Arg Trp 
            420                 425                 430         


Thr Ile Leu Thr Tyr Gly Leu Ser Phe Gln Met Val Cys Leu Phe Ile 
        435                 440                 445             


Ile Gly Gly Met Gly Phe Ala Ser Gly Ser Ser Ala Ser Asn Ala Ala 
    450                 455                 460                 


Gly Gly Leu Leu Leu Ala Leu Ser Phe Phe Tyr Asn Ala Gly Ile Gly 
465                 470                 475                 480 


Ala Val Val Tyr Cys Ile Val Ala Glu Ile Pro Ser Ala Glu Leu Arg 
                485                 490                 495     


Thr Lys Thr Ile Val Leu Ala Arg Ile Cys Tyr Asn Leu Met Ala Val 
            500                 505                 510         


Phe Asn Ala Ile Leu Thr Pro Tyr Met Leu Asn Val Ser Asp Trp Asn 
        515                 520                 525             


Trp Gly Ala Lys Thr Gly Leu Tyr Trp Gly Gly Phe Thr Ala Leu Thr 
    530                 535                 540                 


Leu Ala Trp Val Ile Ile Asp Leu Pro Glu Thr Thr Gly Arg Thr Phe 
545                 550                 555                 560 


Gly Glu Ile Asn Glu Leu Phe Ser Gln Gly Val Pro Ala Arg Lys Phe 
                565                 570                 575     


Ala Ser Thr Val Val Asp Pro Phe Gly Lys Arg Gly Leu Gln Asn Arg 
            580                 585                 590         


Pro Gln Val Asp Asn Ile Ile Asp Arg Phe Ser Ser Ala Ser Gln Gln 
        595                 600                 605             


Ala Leu 
    610 


<210>  33
<211>  520
<212>  PRT
<213>  Hybrid yeast_7

<400>  33

Met Gly Tyr Asp Ile Ala Asn Tyr Glu Lys Val Trp Pro Thr Tyr Gly 
1               5                   10                  15      


Thr Asn Glu Asp Cys Phe Ala Leu Ile Glu Lys Thr His Lys Leu Gly 
            20                  25                  30          


Met Lys Phe Ile Thr Asp Leu Val Ile Asn His Cys Ser Ser Glu His 
        35                  40                  45              


Glu Trp Phe Lys Glu Ser Arg Ser Ser Lys Thr Asn Pro Lys Arg Asp 
    50                  55                  60                  


Trp Phe Phe Trp Arg Pro Pro Lys Gly Tyr Asp Ala Glu Gly Lys Pro 
65                  70                  75                  80  


Ile Pro Pro Asn Asn Trp Lys Ser Tyr Phe Gly Gly Ser Ala Trp Thr 
                85                  90                  95      


Phe Asp Glu Lys Thr Gln Glu Phe Tyr Leu Arg Leu Phe Cys Ser Thr 
            100                 105                 110         


Gln Pro Asp Leu Asn Trp Glu Asn Glu Asp Cys Arg Lys Ala Ile Tyr 
        115                 120                 125             


Glu Ser Ala Val Gly Tyr Trp Leu Asp His Gly Val Asp Gly Phe Arg 
    130                 135                 140                 


Ile Asp Val Gly Ser Leu Tyr Ser Lys Val Val Gly Leu Pro Asp Ala 
145                 150                 155                 160 


Pro Val Val Asp Lys Asn Ser Thr Trp Gln Ser Ser Asp Pro Tyr Thr 
                165                 170                 175     


Leu Asn Gly Pro Arg Ile His Glu Phe His Gln Glu Met Asn Gln Phe 
            180                 185                 190         


Ile Arg Asn Arg Val Lys Asp Gly Arg Glu Ile Met Thr Val Gly Glu 
        195                 200                 205             


Met Gln His Ala Ser Asp Glu Thr Lys Arg Leu Tyr Thr Ser Ala Ser 
    210                 215                 220                 


Arg His Glu Leu Ser Glu Leu Phe Asn Phe Ser His Thr Asp Val Gly 
225                 230                 235                 240 


Thr Ser Pro Leu Phe Arg Tyr Asn Leu Val Pro Phe Glu Leu Lys Asp 
                245                 250                 255     


Trp Lys Ile Ala Leu Ala Glu Leu Phe Arg Phe Ile Asn Gly Thr Asp 
            260                 265                 270         


Cys Trp Ser Thr Ile Tyr Leu Glu Asn His Asp Gln Pro Arg Ser Ile 
        275                 280                 285             


Thr Arg Phe Gly Asp Asp Ser Pro Lys Asn Arg Val Ile Ser Gly Lys 
    290                 295                 300                 


Leu Leu Ser Val Leu Leu Ser Ala Leu Thr Gly Thr Leu Tyr Val Tyr 
305                 310                 315                 320 


Gln Gly Gln Glu Leu Gly Gln Ile Asn Phe Lys Asn Trp Ser Val Glu 
                325                 330                 335     


Lys Tyr Glu Asp Val Glu Ile Arg Asn Asn Tyr Arg Leu Ile Lys Glu 
            340                 345                 350         


Glu Cys Gly Glu Asn Ser Glu Glu Met Lys Lys Phe Leu Glu Gly Ile 
        355                 360                 365             


Ala Leu Val Ser Arg Asp His Ala Arg Thr Pro Met Pro Trp Thr Pro 
    370                 375                 380                 


Asn Glu Pro Asn Ala Gly Phe Ser Gly Pro Asn Thr Lys Pro Trp Phe 
385                 390                 395                 400 


Tyr Leu Asn Glu Ser Phe Arg Gln Gly Ile Asn Val Glu Glu Glu Gln 
                405                 410                 415     


Lys Asn Ser Asp Ser Val Leu Ala Phe Trp Lys Lys Ala Leu Glu Phe 
            420                 425                 430         


Arg Lys Asn His Lys Asp Ile Ala Val Tyr Gly Phe Asp Phe Lys Phe 
        435                 440                 445             


Ile Asp Leu Asp Asn Lys Lys Leu Phe Ser Phe Thr Lys Arg Tyr Asn 
    450                 455                 460                 


Asn Lys Thr Leu Phe Ala Ala Leu Asn Phe Ser Ser Asp Ala Thr Asp 
465                 470                 475                 480 


Phe Lys Ile Pro Asn Asp Gly Ser Ser Phe Lys Leu Glu Phe Gly Asn 
                485                 490                 495     


Tyr Pro Lys Asn Glu Val Asp Ala Ser Ser Arg Thr Leu Lys Pro Trp 
            500                 505                 510         


Glu Gly Arg Ile His Ile Asn Glu 
        515                 520 


<210>  34
<211>  581
<212>  PRT
<213>  Hybrid yeast_1

<400>  34

Met Thr Ile Ile His Asn Pro Lys Trp Trp Lys Glu Ala Thr Val Tyr 
1               5                   10                  15      


Gln Ile Tyr Pro Ala Ser Asn Lys Asp Ser Asn Asn Asp Gly Trp Gly 
            20                  25                  30          


Asp Leu Ala Gly Ile Thr Ser Lys Leu Asp Tyr Val Lys Glu Leu Gly 
        35                  40                  45              


Val Asp Ala Ile Trp Val Cys Leu Phe Tyr Asp Ser Pro Gln Glu Asp 
    50                  55                  60                  


Met Gly Tyr Asp Ile Ala Asn Tyr Glu Lys Val Trp Pro Arg Tyr Gly 
65                  70                  75                  80  


Thr Asn Glu Asp Cys Phe Gln Met Ile Glu Glu Ala His Lys Arg Gly 
                85                  90                  95      


Ile Lys Val Ile Val Asp Leu Val Ile Asn His Cys Ser Glu Glu His 
            100                 105                 110         


Glu Trp Phe Lys Glu Ser Lys Ser Ser Lys Thr Asn Pro Lys Arg Asp 
        115                 120                 125             


Trp Phe Phe Trp Arg Pro Pro Lys Gly Phe Asp Glu Lys Gly Asn Pro 
    130                 135                 140                 


Ile Pro Pro Asn Asn Trp Arg Ser Phe Phe Gly Gly Ser Ala Trp Arg 
145                 150                 155                 160 


Tyr Asp Glu Lys Thr Gly Glu Phe Phe Leu His Val Phe Ala Pro Gly 
                165                 170                 175     


Gln Pro Asp Phe Asn Trp Glu Asn Glu Glu Cys Arg Lys Ala Ile Tyr 
            180                 185                 190         


Asp Ser Ser Val Gly Tyr Trp Leu Arg His Asn Val Asp Gly Phe Arg 
        195                 200                 205             


Ile Asp Val Gly Ser Met Tyr Ser Lys Val Glu Gly Leu Pro Asp Ala 
    210                 215                 220                 


Pro Ile Thr Asp Pro Thr Val Pro Tyr Gln Lys Gly Thr Glu Phe Phe 
225                 230                 235                 240 


Ile Asn Gly Pro Arg Ile His Glu Tyr His Lys Glu Met Arg Lys Tyr 
                245                 250                 255     


Met Leu Ser Gln Ile Pro Glu Gly Lys Glu Ile Met Thr Val Gly Glu 
            260                 265                 270         


Val Gly Val Gly Asn Glu Glu Asp Phe Arg Asp Tyr Thr Ser Ala Lys 
        275                 280                 285             


Glu Gly Glu Leu Asn Met Met Phe Asn Phe Lys His Thr Ser Val Gly 
    290                 295                 300                 


Glu Ser Pro Glu Cys Lys Tyr Glu Leu Ile Pro Phe Thr Leu Lys Asp 
305                 310                 315                 320 


Phe Lys Leu Ala Leu Ala Glu Ser Phe Leu Phe Ile Glu Asn Thr Asp 
                325                 330                 335     


Cys Trp Ser Thr Ile Tyr Leu Glu Asn His Asp Gln Pro Arg Ser Val 
            340                 345                 350         


Ser Arg Phe Gly Ser Asp Ser Pro Lys Trp Arg Ala Ile Ser Ser Lys 
        355                 360                 365             


Met Leu Ala Thr Leu Ile Ile Ser Leu Thr Gly Thr Val Phe Ile Tyr 
    370                 375                 380                 


Gln Gly Gln Glu Leu Gly Met Ser Asn Phe Lys Asn Arg Arg Ile Glu 
385                 390                 395                 400 


Gln Ile Lys Cys Val Glu Gly Thr Gly Thr Tyr Ala Ala Ile Lys Arg 
                405                 410                 415     


Asp Tyr Gly Glu Asp Ser Glu Lys Met Lys Lys Phe Phe Glu Ala Leu 
            420                 425                 430         


Ala Leu Ile Ser Arg Asp His Gly Arg Thr Pro Phe Pro Trp Ser Ala 
        435                 440                 445             


Asp Glu Pro Ser Ala Gly Phe Ser Lys Asp Ala Lys Pro Trp Ile Asp 
    450                 455                 460                 


Met Asn Glu Ser Phe Arg Asp Gly Ile Asn Ala Glu Ala Glu Leu Lys 
465                 470                 475                 480 


Asp Lys Asn Ser Val Phe Phe Phe Trp Lys Lys Ala Leu Gln Val Arg 
                485                 490                 495     


Lys Glu His Lys Asp Ile Leu Val Tyr Gly His Asn Phe Gln Phe Ile 
            500                 505                 510         


Asp Leu Asp Asn Asp Lys Leu Phe Met Phe Thr Lys Asp Thr Asp Asn 
        515                 520                 525             


Lys Lys Met Phe Ala Val Phe Asn Phe Ser Ser Asp Asn Thr Asp Phe 
    530                 535                 540                 


Ser Val Pro Asp Asn Glu Ala Ser Tyr Thr Met Phe Phe Gly Asn Tyr 
545                 550                 555                 560 


Ala Asn Ser Asn Gly Asp Ser Arg Thr Leu Gln Pro Trp Glu Gly Arg 
                565                 570                 575     


Leu Tyr Leu Leu Lys 
            580     


<210>  35
<211>  581
<212>  PRT
<213>  Hybrid yeast 7

<400>  35

Met Thr Ile Ile His Asn Pro Lys Trp Trp Lys Glu Ala Thr Val Tyr 
1               5                   10                  15      


Gln Ile Tyr Pro Ala Ser Asn Lys Asp Ser Asn Asn Asp Gly Trp Gly 
            20                  25                  30          


Asp Leu Ala Gly Ile Thr Ser Lys Leu Asp Tyr Val Lys Glu Leu Gly 
        35                  40                  45              


Val Asp Ala Ile Trp Val Cys Leu Phe Tyr Asp Ser Pro Gln Glu Asp 
    50                  55                  60                  


Met Gly Tyr Asp Ile Ala Asn Tyr Glu Lys Val Trp Pro Arg Tyr Gly 
65                  70                  75                  80  


Thr Asn Glu Asp Cys Phe Gln Met Ile Glu Glu Ala His Lys Arg Gly 
                85                  90                  95      


Ile Lys Val Ile Val Asp Leu Val Ile Asn His Cys Ser Glu Glu His 
            100                 105                 110         


Glu Trp Phe Lys Glu Ser Lys Ser Ser Lys Thr Asn Pro Lys Arg Asp 
        115                 120                 125             


Trp Phe Phe Trp Arg Pro Pro Lys Gly Phe Asp Glu Lys Gly Asn Pro 
    130                 135                 140                 


Ile Pro Pro Asn Asn Trp Arg Ser Phe Phe Gly Gly Ser Ala Trp Arg 
145                 150                 155                 160 


Tyr Asp Glu Lys Thr Gly Glu Phe Phe Leu His Val Phe Ala Pro Gly 
                165                 170                 175     


Gln Pro Asp Phe Asn Trp Glu Asn Glu Lys Cys Arg Lys Ala Ile Tyr 
            180                 185                 190         


Asp Ser Ser Val Gly Tyr Trp Leu Arg His Asn Val Asp Gly Phe Arg 
        195                 200                 205             


Ile Asp Val Gly Ser Met Tyr Ser Lys Val Glu Gly Leu Pro Asp Ala 
    210                 215                 220                 


Pro Ile Thr Asp Pro Thr Val Pro Tyr Gln Lys Gly Thr Glu Phe Phe 
225                 230                 235                 240 


Ile Asn Gly Pro Arg Ile His Glu Tyr His Lys Glu Met Arg Lys Tyr 
                245                 250                 255     


Met Leu Ser Gln Ile Pro Glu Gly Lys Glu Ile Met Thr Val Gly Glu 
            260                 265                 270         


Val Gly Val Gly Asn Glu Glu Asp Phe Arg Asp Tyr Thr Ser Ala Lys 
        275                 280                 285             


Glu Gly Glu Leu Asn Met Met Phe Asn Phe Lys His Thr Ser Val Gly 
    290                 295                 300                 


Glu Ser Pro Glu Cys Lys Tyr Glu Leu Ile Pro Phe Thr Leu Lys Asp 
305                 310                 315                 320 


Phe Lys Leu Ala Leu Ala Glu Ser Phe Leu Phe Ile Glu Asn Thr Asp 
                325                 330                 335     


Cys Trp Ser Thr Ile Tyr Leu Glu Asn His Asp Gln Pro Arg Ser Val 
            340                 345                 350         


Ser Arg Phe Gly Ser Asp Ser Pro Lys Trp Arg Ala Ile Ser Ser Lys 
        355                 360                 365             


Met Leu Ala Thr Leu Ile Ile Ser Leu Thr Gly Thr Val Phe Ile Tyr 
    370                 375                 380                 


Gln Gly Gln Glu Leu Gly Met Ser Asn Phe Lys Asn Arg Arg Ile Glu 
385                 390                 395                 400 


Gln Ile Lys Cys Val Glu Gly Thr Gly Thr Tyr Ala Ala Ile Lys Arg 
                405                 410                 415     


Asp Tyr Gly Glu Asp Ser Glu Lys Met Lys Lys Phe Phe Glu Ala Leu 
            420                 425                 430         


Ala Leu Ile Ser Arg Asp His Gly Arg Thr Pro Phe Pro Trp Ser Ala 
        435                 440                 445             


Asp Glu Pro Ser Ala Gly Phe Ser Lys Asp Ala Lys Pro Trp Ile Asp 
    450                 455                 460                 


Met Asn Glu Ser Phe Arg Asp Gly Ile Asn Ala Glu Ala Glu Leu Lys 
465                 470                 475                 480 


Asp Lys Asn Ser Val Phe Phe Phe Trp Lys Lys Ala Leu Gln Val Arg 
                485                 490                 495     


Lys Glu His Lys Asp Ile Leu Val Tyr Gly His Asn Phe Gln Phe Ile 
            500                 505                 510         


Asp Leu Asp Asn Asp Lys Leu Phe Met Phe Thr Lys Asp Thr Asp Asn 
        515                 520                 525             


Lys Lys Met Phe Ala Val Phe Asn Phe Ser Ser Asp Asn Thr Asp Phe 
    530                 535                 540                 


Ser Val Pro Asp Asn Glu Ala Ser Tyr Thr Met Phe Phe Gly Asn Tyr 
545                 550                 555                 560 


Ala Asn Ser Asn Gly Asp Ser Arg Thr Leu Gln Pro Trp Glu Gly Arg 
                565                 570                 575     


Leu Tyr Leu Leu Lys 
            580     


<210>  36
<211>  575
<212>  PRT
<213>  Hybrid_7 allele

<400>  36

Pro Lys Trp Trp Lys Glu Ala Thr Ile Tyr Gln Ile Tyr Pro Ala Ser 
1               5                   10                  15      


Phe Lys Asp Ser Asn Asn Asp Gly Trp Gly Asp Leu Ala Gly Ile Thr 
            20                  25                  30          


Ser Lys Leu Asp Tyr Ile Lys Glu Leu Gly Val Asp Ala Ile Trp Val 
        35                  40                  45              


Cys Pro Phe Tyr Asp Ser Pro Gln Glu Asp Met Gly Tyr Asp Ile Ala 
    50                  55                  60                  


Asn Tyr Glu Lys Val Trp Pro Arg Tyr Gly Thr Ser Glu Asp Cys Phe 
65                  70                  75                  80  


Gln Met Ile Glu Glu Ser His Lys Arg Gly Ile Lys Val Ile Val Asp 
                85                  90                  95      


Leu Val Ile Asn His Cys Ser Glu Glu His Glu Trp Phe Lys Glu Ser 
            100                 105                 110         


Arg Ser Ser Lys Thr Asn Ala Lys Arg Asp Trp Phe Phe Trp Lys Pro 
        115                 120                 125             


Pro Lys Gly Tyr Glu Ile Asp Gly Thr Pro Ile Pro Pro Asn Asn Trp 
    130                 135                 140                 


Arg Ser Phe Phe Gly Gly Ser Ala Trp Lys Tyr Asp Glu Asn Thr Glu 
145                 150                 155                 160 


Glu Phe Phe Leu His Val Phe Ala Pro Gly Gln Pro Asp Phe Asn Trp 
                165                 170                 175     


Glu Asn Lys Glu Cys Arg Gln Ala Ile Tyr Asp Ser Ser Val Gly Phe 
            180                 185                 190         


Trp Leu Arg His Asn Val Asp Gly Phe Arg Ile Asp Val Gly Ser Met 
        195                 200                 205             


Tyr Ser Lys Val Glu Gly Leu Pro Asp Ala Ser Ile Thr Asp Pro Thr 
    210                 215                 220                 


Val Pro Tyr Gln Asp Gly Thr Asp Phe Phe Val Asn Gly Pro Arg Ile 
225                 230                 235                 240 


His Glu Tyr His Lys Glu Met Arg Gln Tyr Met Tyr Thr Gln Ile Pro 
                245                 250                 255     


Glu Gly Lys Glu Ile Met Thr Val Gly Glu Val Gly Ile Gly Asn Glu 
            260                 265                 270         


Lys Asp Phe Lys Asp Tyr Thr Ser Ser Lys Glu Glu Glu Phe Asn Met 
        275                 280                 285             


Met Phe Asn Phe Lys His Thr Ser Val Gly Glu Ser Pro Glu Phe Lys 
    290                 295                 300                 


Tyr Glu Leu Ile Pro Phe Thr Leu Lys Asp Phe Lys Leu Ala Leu Ala 
305                 310                 315                 320 


Glu Ser Phe Leu Phe Ile Glu Gly Thr Asp Cys Trp Ser Thr Ile Tyr 
                325                 330                 335     


Leu Glu Asn His Asp Gln Pro Arg Ser Val Ser Arg Phe Gly Ser Asp 
            340                 345                 350         


Ser Pro Glu Trp Arg Glu Ile Ser Ser Lys Met Leu Ala Thr Leu Ile 
        355                 360                 365             


Ile Ser Leu Thr Gly Thr Val Phe Ile Tyr Gln Gly Gln Glu Leu Gly 
    370                 375                 380                 


Met Pro Asn Phe Lys Asn Arg Lys Ile Glu Gln Ile Lys Cys Val Glu 
385                 390                 395                 400 


Gly Thr Gly Thr Tyr Gly Ala Ile Lys Arg Asp Tyr Gly Glu Asp Ser 
                405                 410                 415     


Glu Lys Met Lys Lys Phe Tyr Glu Ala Leu Ala Leu Ile Ser Arg Asp 
            420                 425                 430         


His Gly Arg Thr Pro Phe Pro Trp Ser Gly Glu Lys Pro Tyr Ala Gly 
        435                 440                 445             


Phe Ser Lys Asn Ala Lys Pro Trp Ile Asp Ile Asn Glu Ser Phe Val 
    450                 455                 460                 


Glu Gly Ile Asn Ala Glu Ala Glu Leu Asn Asp Glu Asn Ser Val Phe 
465                 470                 475                 480 


Phe Phe Trp Lys Arg Ala Leu Gln Val Arg Lys Glu His Lys Asn Met 
                485                 490                 495     


Leu Val Tyr Gly Asp Asn Phe Gln Phe Tyr Asp Leu Asp Asn Glu Lys 
            500                 505                 510         


Leu Phe Met Phe Thr Lys Asp Ser Gly Asp Lys Lys Met Phe Ala Val 
        515                 520                 525             


Phe Asn Phe Cys Ser Asp Ser Thr Glu Phe Ser Val Pro Asp Asn Lys 
    530                 535                 540                 


Ala Ser Tyr Asp Met Phe Phe Gly Asn Tyr Ala Asn Ser Asp Gly Lys 
545                 550                 555                 560 


Ser Tyr Thr Leu Lys Pro Trp Glu Gly Arg Leu Tyr Tyr Ser Asn 
                565                 570                 575 


<210>  37
<211>  558
<212>  PRT
<213>  Hybrid_yeast 7

<400>  37

Asn Ser Thr Glu Arg Tyr Asn Leu Ser Pro Ser Pro Glu Asp Glu Asp 
1               5                   10                  15      


Phe Glu Ala Pro Thr Glu Glu Glu Met Gln Thr Leu Arg His Val Gly 
            20                  25                  30          


Gly Lys Ile Pro Met Arg Cys Trp Leu Ile Ala Ile Val Glu Leu Ser 
        35                  40                  45              


Glu Arg Phe Ser Tyr Tyr Gly Leu Ser Ala Pro Phe Gln Asn Tyr Met 
    50                  55                  60                  


Glu Tyr Gly Pro Asn Asp Ser Pro Lys Gly Val Leu Ser Leu Asn Ser 
65                  70                  75                  80  


Gln Gly Ala Thr Gly Leu Ser Tyr Phe Phe Gln Phe Trp Cys Tyr Val 
                85                  90                  95      


Thr Pro Val Phe Gly Gly Tyr Val Ala Asp Thr Phe Trp Gly Lys Tyr 
            100                 105                 110         


Asn Thr Ile Cys Cys Gly Thr Ala Ile Tyr Ile Ala Gly Ile Phe Ile 
        115                 120                 125             


Leu Phe Ile Thr Ser Ile Pro Ser Val Gly Asn Arg Asp Ser Ala Ile 
    130                 135                 140                 


Gly Gly Phe Ile Ala Ala Ile Ile Leu Ile Gly Ile Ala Thr Gly Met 
145                 150                 155                 160 


Ile Lys Ala Asn Leu Ser Val Leu Ile Ala Asp Gln Leu Pro Lys Arg 
                165                 170                 175     


Lys Pro Ser Ile Lys Val Leu Lys Ser Gly Glu Arg Val Ile Val Asp 
            180                 185                 190         


Ser Asn Ile Thr Leu Gln Asn Val Phe Met Phe Phe Tyr Phe Met Ile 
        195                 200                 205             


Asn Val Gly Ser Leu Ser Leu Met Ala Thr Thr Glu Leu Glu Tyr His 
    210                 215                 220                 


Lys Gly Phe Trp Ala Ala Tyr Leu Leu Pro Phe Cys Phe Phe Trp Ile 
225                 230                 235                 240 


Ala Val Val Thr Leu Ile Phe Gly Lys Lys Gln Tyr Ile Gln Arg Pro 
                245                 250                 255     


Ile Gly Asp Lys Val Ile Ala Lys Ser Phe Lys Val Cys Trp Ile Leu 
            260                 265                 270         


Thr Lys Asn Lys Phe Asp Phe Asn Ala Ala Lys Pro Ser Val His Pro 
        275                 280                 285             


Glu Lys Asn Tyr Pro Trp Asn Asp Lys Phe Val Asp Glu Ile Lys Arg 
    290                 295                 300                 


Ala Leu Ala Ala Cys Lys Val Phe Ile Phe Tyr Pro Ile Tyr Trp Thr 
305                 310                 315                 320 


Gln Tyr Gly Thr Met Ile Ser Ser Phe Ile Thr Gln Ala Ser Met Met 
                325                 330                 335     


Glu Leu His Gly Ile Pro Asn Asp Phe Leu Gln Ala Phe Asp Ser Ile 
            340                 345                 350         


Ala Leu Ile Ile Phe Ile Pro Ile Phe Glu Lys Phe Val Tyr Pro Phe 
        355                 360                 365             


Ile Arg Arg Tyr Thr Pro Leu Lys Pro Ile Thr Lys Ile Phe Phe Gly 
    370                 375                 380                 


Phe Met Phe Gly Ser Phe Ala Met Thr Trp Ala Ala Val Leu Gln Ser 
385                 390                 395                 400 


Phe Val Tyr Lys Ala Gly Pro Trp Tyr Asn Glu Pro Leu Gly His Asn 
                405                 410                 415     


Thr Pro Asn His Val His Val Cys Trp Gln Ile Pro Ala Tyr Val Leu 
            420                 425                 430         


Ile Ser Phe Ser Glu Ile Phe Ala Ser Ile Thr Gly Leu Glu Tyr Ala 
        435                 440                 445             


Tyr Ser Lys Ala Pro Ala Ser Met Lys Ser Phe Ile Met Ser Ile Phe 
    450                 455                 460                 


Leu Leu Thr Asn Ala Phe Gly Ser Ala Ile Gly Cys Ala Leu Ser Pro 
465                 470                 475                 480 


Val Thr Val Asp Pro Lys Phe Thr Trp Leu Phe Thr Gly Leu Ala Val 
                485                 490                 495     


Ala Cys Phe Ile Ser Gly Cys Leu Phe Trp Leu Cys Phe Arg Lys Tyr 
            500                 505                 510         


Asn Asp Thr Glu Glu Glu Met Asn Ala Met Asp Tyr Glu Glu Glu Asp 
        515                 520                 525             


Glu Phe Asp Leu Asn Pro Ile Ser Ala Pro Lys Ala Asn Asp Ile Glu 
    530                 535                 540                 


Ile Leu Glu Pro Met Glu Ser Leu Arg Ser Thr Thr Lys Tyr 
545                 550                 555             


<210>  38
<211>  601
<212>  PRT
<213>  Hybrid yeast_7

<400>  38

Met Leu Asn His Leu Ser Gln Gly Ser Asp Asp Ile Gln Asp Glu Lys 
1               5                   10                  15      


Gln Gly Asp Phe Pro Val Ile Glu Glu Glu Lys Asn Gln Thr Val Thr 
            20                  25                  30          


Leu Lys Asp Ser Tyr Val Ser Asp Asp Ala Ala Asn Ser Thr Glu His 
        35                  40                  45              


Tyr Asn Leu Ser Pro Ser Leu Glu Glu Asp Glu Phe Glu Ala Pro Thr 
    50                  55                  60                  


Asp Glu Glu Leu Arg Ser Leu Arg His Val Gly Gly Lys Ile Pro Met 
65                  70                  75                  80  


Arg Cys Trp Leu Ile Ala Ile Val Glu Leu Ser Glu Arg Phe Ser Tyr 
                85                  90                  95      


Tyr Gly Leu Ser Ala Pro Phe Gln Asn Tyr Met Glu Tyr Gly Pro Lys 
            100                 105                 110         


Asp Thr Pro Lys Gly Val Leu Ser Leu Asn Ser Gln Gly Ala Thr Gly 
        115                 120                 125             


Leu Ser Tyr Phe Phe Gln Phe Trp Cys Tyr Val Thr Pro Val Phe Gly 
    130                 135                 140                 


Gly Tyr Val Ala Asp Thr Phe Trp Gly Lys Tyr Asn Thr Ile Cys Cys 
145                 150                 155                 160 


Gly Thr Ala Ile Tyr Ile Ala Gly Ile Phe Ile Leu Leu Ile Thr Ser 
                165                 170                 175     


Ile Pro Ser Val Gly Asn Arg Asp Ser Ala Leu Gly Gly Phe Ile Ala 
            180                 185                 190         


Ser Ile Ile Leu Ile Gly Ile Ala Thr Gly Met Ile Lys Ala Asn Leu 
        195                 200                 205             


Ser Val Leu Ile Ala Asp Gln Leu Pro Lys Arg Lys Pro Ser Ile Lys 
    210                 215                 220                 


Val Leu Lys Ser Gly Glu Arg Val Ile Val Asp Ser Asn Ile Thr Leu 
225                 230                 235                 240 


Gln Asn Val Phe Met Phe Phe Tyr Phe Met Ile Asn Val Gly Ser Leu 
                245                 250                 255     


Ser Leu Met Ala Thr Thr Glu Leu Glu Tyr His Lys Gly Phe Trp Ala 
            260                 265                 270         


Ala Tyr Leu Leu Pro Phe Cys Phe Phe Trp Val Ala Val Val Thr Leu 
        275                 280                 285             


Val Phe Gly Lys Lys Gln Tyr Ile Gln Arg Pro Ile Gly Asp Lys Val 
    290                 295                 300                 


Ile Ala Lys Ser Phe Arg Val Cys Trp Ile Leu Thr Lys Asn Lys Phe 
305                 310                 315                 320 


Asp Phe Asn Ala Ala Lys Pro Ser Val His Pro Glu Lys Glu Tyr Pro 
                325                 330                 335     


Trp Asn Asp Lys Phe Val Asp Glu Ile Lys Arg Ala Leu Ala Ala Cys 
            340                 345                 350         


Lys Val Phe Val Phe Tyr Pro Ile Tyr Trp Thr Gln Tyr Gly Thr Met 
        355                 360                 365             


Ile Ser Ser Phe Ile Thr Gln Ala Gly Met Met Glu Leu His Gly Ile 
    370                 375                 380                 


Pro Asn Asp Phe Leu Gln Ala Phe Asp Ser Ile Ala Leu Ile Ile Phe 
385                 390                 395                 400 


Ile Pro Ile Phe Glu Lys Phe Ile Tyr Pro Phe Ile Arg Arg Tyr Thr 
                405                 410                 415     


Pro Phe Lys Pro Ile Thr Lys Ile Phe Phe Gly Phe Met Phe Gly Ser 
            420                 425                 430         


Leu Ala Met Thr Trp Ala Ala Val Leu Gln Ser Phe Val Tyr Lys Ala 
        435                 440                 445             


Gly Pro Trp Tyr Ser Ala Pro Leu Gly His Asn Thr Pro Asn His Val 
    450                 455                 460                 


His Val Cys Trp Gln Ile Pro Ala Tyr Val Leu Ile Ser Phe Ser Glu 
465                 470                 475                 480 


Ile Phe Ala Ser Ile Thr Gly Leu Glu Tyr Ala Tyr Ser Lys Ala Pro 
                485                 490                 495     


Ala Ser Met Lys Ser Phe Ile Met Ser Ile Phe Leu Leu Thr Asn Ala 
            500                 505                 510         


Phe Gly Ser Ala Ile Gly Cys Ala Leu Ser Pro Val Thr Val Asp Pro 
        515                 520                 525             


Lys Phe Thr Trp Leu Phe Thr Gly Leu Ala Val Ala Cys Phe Ile Ser 
    530                 535                 540                 


Gly Cys Leu Phe Trp Phe Cys Phe Arg Lys Tyr Asn Asp Thr Glu Glu 
545                 550                 555                 560 


Glu Met Asn Ala Met Asp Tyr Glu Glu Glu Asp Glu Phe Asp Leu Asn 
                565                 570                 575     


Pro Ile Ser Gln Pro Lys Gly Asn Asp Ile Glu Ile Leu Glu Pro Met 
            580                 585                 590         


Gly Ser Leu Lys Ser Thr Thr Lys Tyr 
        595                 600     


<210>  39
<211>  543
<212>  PRT
<213>  Hybrid yeast_7

<400>  39

Met Ser Ala Asp Ala Ser Thr Asn Ser Asn Ala Ser Leu Asp Glu Lys 
1               5                   10                  15      


Asn Leu Asn Ile Thr Ser Glu Ala Glu Ile Lys Asn Glu Asp Val Thr 
            20                  25                  30          


Ala Glu Pro Val Leu Ser Thr Val Leu Ser Pro Asn Gly Lys Ile Val 
        35                  40                  45              


Tyr Ile Ser Asp Lys Val Asp Glu Ala Met Lys Leu Ala Glu Glu Ala 
    50                  55                  60                  


Lys Glu Ile Glu Val Thr Pro Glu Glu Asp Arg Lys Leu Arg Trp Lys 
65                  70                  75                  80  


Ile Asp Tyr Cys Met Phe Pro Leu Met Cys Ile Leu Tyr Ala Val Gln 
                85                  90                  95      


Phe Met Asp Lys Ile Ser Thr Ser Ser Ala Ala Val Met Gly Leu Arg 
            100                 105                 110         


Thr Asp Leu Lys Met His Gly Asp Gln Tyr Ser Trp Val Thr Ser Ala 
        115                 120                 125             


Phe Tyr Phe Gly Tyr Leu Phe Met Asn Leu Gly Pro Val Gln Phe Ile 
    130                 135                 140                 


Phe Gln Arg Thr Ser His Met Ser Lys Met Leu Ala Val Phe Ile Val 
145                 150                 155                 160 


Ile Trp Gly Met Leu Leu Ala Leu His Ala Ala Pro Thr Val Lys Tyr 
                165                 170                 175     


Pro Ser Phe Ile Val Leu Arg Val Leu Leu Gly Cys Ala Glu Ser Val 
            180                 185                 190         


Val Thr Pro Cys Phe Thr Ile Ile Thr Ala Gln Tyr Trp Lys Thr Glu 
        195                 200                 205             


Glu Gln Phe Thr Arg Val Ser Ile Trp Phe Gly Met Asn Gly Leu Gly 
    210                 215                 220                 


Ser Ile Leu Ile Asn Ala Ile Ala Tyr Gly Val Tyr Ile His Gln Asp 
225                 230                 235                 240 


Ser Tyr Ala Ile Lys Gly Trp Arg Thr Leu Phe Val Ile Thr Gly Val 
                245                 250                 255     


Ile Thr Ile Phe Ile Gly Ile Leu Ile Phe Leu Trp Ile Pro Asp Asp 
            260                 265                 270         


Pro Ser Lys Ala Arg Phe Leu Ser Lys Arg Glu Lys Leu Met Val Val 
        275                 280                 285             


Gln Arg Ile Arg Ser Asn Gln Gln Gly Phe Gly Asn His Glu Ile Lys 
    290                 295                 300                 


Lys Tyr Gln Ile Ile Glu Ala Leu Lys Asp Val Arg Thr Trp Leu Tyr 
305                 310                 315                 320 


Phe Leu Phe Thr Val Ser Ser Asn Ile Pro Asn Gly Gly Ile Ser Ser 
                325                 330                 335     


Phe Met Ser Ile Leu Leu Asn Ser Asp Phe Gly Tyr Ser Ser Lys Glu 
            340                 345                 350         


Thr Leu Leu Met Gly Leu Pro Thr Gly Ala Val Glu Leu Val Gly Cys 
        355                 360                 365             


Pro Leu Phe Gly Ile Leu Ala Val Tyr Ala Ala Asn Lys Lys Ile Pro 
    370                 375                 380                 


Phe Trp Lys Tyr Lys Leu Ser Trp Ala Ile Phe Ala Ala Val Leu Ala 
385                 390                 395                 400 


Leu Ile Ala Ser Cys Met Leu Gly Phe Ala Thr Asn Ser Lys Lys Ala 
                405                 410                 415     


Arg Leu Ala Gly Ala Tyr Leu Trp Tyr Ile Ser Pro Val Ser Phe Ile 
            420                 425                 430         


Cys Val Leu Ser Asn Ile Ser Ala Asn Ser Ser Gly Tyr Ser Lys Lys 
        435                 440                 445             


Trp Thr Val Ser Ser Ile Asn Leu Val Ala Tyr Ala Ala Ala Asn Leu 
    450                 455                 460                 


Ala Gly Pro Gln Thr Phe Ile Ala Lys Gln Ala Pro Lys Tyr His Gly 
465                 470                 475                 480 


Ala Lys Val Ala Met Val Val Cys Tyr Ala Val Met Ile Val Leu Leu 
                485                 490                 495     


Ser Ile Leu Leu Ile Val Asn Leu Arg Glu Asn Lys Arg Arg Asp Lys 
            500                 505                 510         


Ile Ala Ala Glu Arg Gly Phe Pro Glu Glu Thr Glu Asn Leu Glu Phe 
        515                 520                 525             


Ser Asp Leu Thr Asp Phe Glu Asn Pro Asn Phe Arg Tyr Thr Leu 
    530                 535                 540             


<210>  40
<211>  543
<212>  PRT
<213>  Hybrid yeast_7

<400>  40

Met Ser Gly Gly Ala Ser Thr Asn Ser Asn Ala Ser Ile Asp Glu Lys 
1               5                   10                  15      


Asn Leu Asn Ile Thr Ser Glu Ala Glu Ile Lys Asn Glu Asp Val Tyr 
            20                  25                  30          


Ala Glu Pro Val Leu Ser Thr Val Leu Ser Pro Asn Gly Lys Val Val 
        35                  40                  45              


Tyr Ile Ser Asp Lys Val Asp Glu Ala Met Lys Leu Ala Asp Glu Ala 
    50                  55                  60                  


Lys Glu Ile Glu Val Thr Pro Glu Glu Asp Arg Lys Leu Arg Trp Lys 
65                  70                  75                  80  


Ile Asp Tyr Cys Met Phe Pro Leu Met Cys Ile Leu Tyr Ala Val Gln 
                85                  90                  95      


Phe Met Asp Lys Ile Ser Thr Ser Ser Ala Ala Val Met Gly Leu Arg 
            100                 105                 110         


Thr Asp Leu Lys Met His Gly Asp Gln Tyr Ser Trp Val Thr Ser Ala 
        115                 120                 125             


Phe Tyr Phe Gly Tyr Leu Phe Met Asn Leu Gly Pro Val Gln Leu Ile 
    130                 135                 140                 


Phe Gln Lys Ser Lys His Met Ser Lys Met Leu Ala Ile Phe Ile Ile 
145                 150                 155                 160 


Val Trp Gly Leu Leu Leu Ala Leu His Ala Val Pro Ser Val Lys Tyr 
                165                 170                 175     


Ser Ser Phe Ile Ala Leu Arg Val Leu Leu Gly Cys Ala Glu Ser Val 
            180                 185                 190         


Val Thr Pro Cys Phe Thr Ile Ile Thr Ala Gln Tyr Trp Lys Thr Glu 
        195                 200                 205             


Glu Gln Phe Thr Arg Ile Ser Ile Trp Phe Gly Met Asn Gly Leu Gly 
    210                 215                 220                 


Ser Ile Leu Ile Asn Ala Ile Ala Tyr Gly Val Tyr Ile His Gln Glu 
225                 230                 235                 240 


Ser Tyr Ala Ile Lys Gly Trp Arg Ala Leu Phe Val Ile Thr Gly Val 
                245                 250                 255     


Ile Thr Ile Phe Val Gly Ala Leu Ile Phe Leu Trp Ile Pro Asp Asp 
            260                 265                 270         


Pro Ser Lys Ala Arg Phe Leu Ser Lys Arg Glu Lys Leu Met Val Val 
        275                 280                 285             


Gln Arg Ile Arg Ser Asn Gln Gln Gly Phe Gly Asn His Glu Ile Lys 
    290                 295                 300                 


Lys Tyr Gln Ile Val Glu Ala Leu Lys Asp Val Arg Thr Trp Leu Tyr 
305                 310                 315                 320 


Phe Leu Phe Thr Val Ser Ser Asn Ile Pro Asn Gly Gly Ile Ser Ser 
                325                 330                 335     


Phe Met Ser Ile Leu Leu Asn Ser Asp Phe Gly Tyr Leu Ser Lys Asp 
            340                 345                 350         


Thr Leu Leu Met Gly Leu Pro Thr Gly Ala Val Glu Leu Val Gly Cys 
        355                 360                 365             


Pro Leu Phe Gly Ile Leu Ala Val Tyr Ala Ala Asn Lys Lys Ile Pro 
    370                 375                 380                 


Phe Trp Lys Tyr Lys Leu Ala Trp Ala Ile Phe Ala Ala Val Leu Ala 
385                 390                 395                 400 


Leu Ile Ala Ser Cys Met Leu Gly Phe Ala Thr Ser Ser Lys Lys Ala 
                405                 410                 415     


Arg Leu Ala Gly Ala Tyr Leu Trp Tyr Ile Ser Pro Val Ser Phe Ile 
            420                 425                 430         


Cys Val Leu Ser Asn Ile Ser Ala Asn Ser Ser Gly Tyr Ser Lys Lys 
        435                 440                 445             


Trp Thr Val Ser Ser Ile Asn Leu Ala Ala Tyr Ala Ala Ala Asn Leu 
    450                 455                 460                 


Ala Gly Pro Gln Thr Phe Ile Ala Lys Gln Ala Pro Lys Tyr His Gly 
465                 470                 475                 480 


Ala Lys Val Ala Met Val Val Cys Tyr Ala Val Met Ile Val Leu Leu 
                485                 490                 495     


Ser Ala Leu Leu Leu Ile Asn Met Arg Glu Asn Lys Arg Arg Asp Lys 
            500                 505                 510         


Ile Ala Ala Glu Arg Gly Tyr Pro Glu Glu Thr Ala Asn Leu Glu Phe 
        515                 520                 525             


Ser Asp Leu Thr Asp Phe Glu Asn Pro Asn Phe Arg Tyr Thr Leu 
    530                 535                 540             


<210>  41
<211>  828
<212>  PRT
<213>  Hybrid_yeast 7

<400>  41

Met Ser Val Ala Asp Asp Asp Leu Gly Ser Leu Gln Gly His Ile Arg 
1               5                   10                  15      


Arg Thr Leu Arg Ser Ile His Asn Leu Pro Tyr Phe Arg Tyr Thr Arg 
            20                  25                  30          


Gly Pro Thr Glu Arg Ala Asp Met Ser Arg Ala Leu Lys Glu Phe Ile 
        35                  40                  45              


Tyr Arg Tyr Leu Tyr Phe Val Ile Ser Asn Ser Gly Glu Asn Leu Pro 
    50                  55                  60                  


Thr Leu Phe Asn Ala His Pro Lys Gln Lys Leu Ser Asn Pro Glu Leu 
65                  70                  75                  80  


Thr Val Phe Pro Asp Ser Leu Glu Asp Ala Val Asp Ile Asp Lys Ile 
                85                  90                  95      


Thr Ser Gln Gln Thr Ile Pro Phe Tyr Lys Ile Asp Glu Ser Arg Ile 
            100                 105                 110         


Gly Asp Val His Lys His Thr Gly Arg Asn Cys Gly Arg Lys Phe Lys 
        115                 120                 125             


Ile Gly Glu Pro Leu Tyr Arg Cys His Glu Cys Gly Cys Asp Asp Thr 
    130                 135                 140                 


Cys Val Leu Cys Ile His Cys Phe Asn Pro Lys Asp His Val Asn His 
145                 150                 155                 160 


His Val Cys Thr Asp Ile Cys Thr Glu Phe Thr Ser Gly Ile Cys Asp 
                165                 170                 175     


Cys Gly Asp Glu Glu Ala Trp Asn Ser Pro Leu His Cys Lys Ala Glu 
            180                 185                 190         


Glu Gln Glu Asn Asp Ile Ser Glu Asp Pro Ala Thr Asn Ala Asp Ile 
        195                 200                 205             


Lys Glu Glu Asp Val Trp Asn Asp Ser Val Asn Ile Ala Leu Val Glu 
    210                 215                 220                 


Leu Val Leu Ala Glu Val Phe Asp Tyr Phe Ile Asp Val Phe Asn Gln 
225                 230                 235                 240 


Asn Ile Glu Pro Leu Pro Thr Ile Gln Lys Asp Ile Thr Ile Lys Leu 
                245                 250                 255     


Arg Glu Met Thr Gln Gln Gly Lys Met Tyr Glu Arg Ala Gln Phe Leu 
            260                 265                 270         


Asn Asp Leu Lys Tyr Glu Asn Asp Tyr Met Phe Asp Gly Thr Thr Thr 
        275                 280                 285             


Ala Lys Thr Ser Pro Ser Asn Ser Pro Glu Ala Ser Pro Ser Leu Ala 
    290                 295                 300                 


Lys Ile Asp Pro Glu Asn Tyr Thr Val Ile Ile Tyr Asn Asp Glu Tyr 
305                 310                 315                 320 


His Asn Tyr Ser Gln Ala Thr Thr Ala Leu Arg Gln Gly Val Pro Asp 
                325                 330                 335     


Asn Val His Ile Asp Leu Leu Thr Ser Arg Ile Asp Gly Glu Gly Arg 
            340                 345                 350         


Ala Met Leu Lys Cys Ser Gln Asp Ser Ser Ser Val Leu Gly Gly Phe 
        355                 360                 365             


Phe Ala Val Gln Thr Asn Gly Leu Ser Ala Thr Leu Thr Ser Trp Ser 
    370                 375                 380                 


Glu Tyr Leu His Gln Glu Thr Cys Lys Tyr Ile Ile Leu Trp Ile Thr 
385                 390                 395                 400 


His Cys Leu Asn Ile Pro Asn Ser Ser Phe Gln Thr Thr Phe Arg Asn 
                405                 410                 415     


Met Met Gly Lys Thr Leu Cys Ser Glu Tyr Leu Asn Ala Thr Glu Cys 
            420                 425                 430         


Arg Asp Met Thr Pro Val Val Glu Lys Tyr Phe Ser Asn Lys Phe Asp 
        435                 440                 445             


Lys Asn Asp Pro Tyr Arg Tyr Ile Asp Leu Ser Ile Leu Ala Asp Gly 
    450                 455                 460                 


Asn Gln Ile Pro Leu Gly His His Lys Ile Leu Pro Glu Ser Ser Thr 
465                 470                 475                 480 


His Ser Leu Ser Pro Leu Ile Asn Asp Val Glu Thr Pro Thr Ser Arg 
                485                 490                 495     


Thr Tyr Ser Asn Thr Arg Leu Gln His Ile Leu Tyr Phe Asp Asn Arg 
            500                 505                 510         


Tyr Trp Lys Arg Leu Arg Lys Asp Ile Gln Asn Val Ile Ile Pro Thr 
        515                 520                 525             


Leu Ala Ser Ser Asn Leu Tyr Lys Pro Ile Phe Cys Gln Gln Val Val 
    530                 535                 540                 


Glu Ile Phe Asn His Ile Thr Arg Ser Val Ala Tyr Met Asp Arg Glu 
545                 550                 555                 560 


Pro Gln Leu Thr Ala Ile Arg Glu Cys Val Val Gln Leu Phe Thr Cys 
                565                 570                 575     


Pro Thr Asn Ala Lys Asn Ile Phe Glu Asn Gln Ser Phe Leu Asp Ile 
            580                 585                 590         


Val Trp Ser Ile Ile Asp Ile Phe Lys Glu Phe Cys Lys Val Glu Gly 
        595                 600                 605             


Gly Val Leu Ile Trp Gln Arg Val Gln Lys Ser Asn Leu Thr Lys Ser 
    610                 615                 620                 


Tyr Ser Ile Ser Phe Lys Gln Gly Leu Tyr Thr Val Glu Thr Leu Leu 
625                 630                 635                 640 


Ser Lys Val His Asp Pro Asn Ile Pro Leu Arg Pro Lys Glu Ile Ile 
                645                 650                 655     


Ser Leu Leu Thr Leu Cys Lys Leu Phe Asn Gly Ala Trp Lys Ile Lys 
            660                 665                 670         


Arg Lys Glu Gly Glu His Val Leu His Glu Asp Gln Asn Phe Ile Ser 
        675                 680                 685             


Tyr Leu Glu Tyr Thr Thr Ser Ile Tyr Ser Ile Ile Gln Thr Ala Glu 
    690                 695                 700                 


Lys Val Ser Glu Lys Ser Lys Asp Ser Ile Asp Ser Lys Leu Phe Leu 
705                 710                 715                 720 


Asn Ala Ile Arg Ile Ile Ser Ser Phe Leu Gly Asn Arg Ser Leu Thr 
                725                 730                 735     


Tyr Lys Leu Ile Tyr Asp Ser His Glu Val Ile Lys Phe Ser Val Ser 
            740                 745                 750         


His Glu Arg Val Ala Phe Met Asn Pro Leu Gln Thr Met Leu Ser Phe 
        755                 760                 765             


Leu Ile Glu Lys Val Ser Leu Lys Asp Ala Tyr Glu Ala Leu Glu Asp 
    770                 775                 780                 


Cys Ser Asp Phe Leu Lys Ile Ser Asp Phe Ser Leu Arg Ser Val Val 
785                 790                 795                 800 


Leu Cys Ser Gln Ile Asp Val Gly Phe Trp Val Arg Asn Gly Met Ser 
                805                 810                 815     


Val Leu His Gln Ala Ser Tyr Tyr Lys Asn Asn Pro 
            820                 825             


<210>  42
<211>  1950
<212>  PRT
<213>  Hybrid yeast_7

<400>  42

Met Ser Phe Thr Asp Asn Gly Leu Gly Ser Leu Lys Ala His Ile Arg 
1               5                   10                  15      


Arg Thr Leu Arg Ser Ile His Asn Leu Pro Tyr Phe Arg Phe Thr Arg 
            20                  25                  30          


Gly Pro Thr Glu Arg Ala Asp Met Ser Arg Ala Leu Lys Glu Phe Ile 
        35                  40                  45              


Tyr Arg Tyr Leu Tyr Phe Ile Ile Ser Asn Asp Gly Glu Asn Leu Ser 
    50                  55                  60                  


Thr Leu Phe Thr Ala His Pro Lys Gln Lys Ser Ser Asn Gln Glu Leu 
65                  70                  75                  80  


Ala Val Phe Pro Glu Ser Leu Glu Asp Ala Leu Asp Val Asp Lys Ile 
                85                  90                  95      


Thr Ser Gln Gly Thr Phe Pro Phe Tyr Lys Ile Asp Glu Ser Lys Ile 
            100                 105                 110         


Gly Asp Val His Lys His Thr Gly Arg Asn Cys Gly Arg Lys Phe Lys 
        115                 120                 125             


Ile Gly Glu Pro Leu Tyr Arg Cys His Glu Cys Gly Cys Asp Asp Thr 
    130                 135                 140                 


Cys Val Leu Cys Ile His Cys Phe Asn Pro Lys Asp His Ile Asn His 
145                 150                 155                 160 


His Val Cys Thr Asp Ile Cys Ser Glu Phe Thr Ser Gly Ile Cys Asp 
                165                 170                 175     


Cys Gly Asp Glu Glu Ala Trp Asn Ser Ser Leu His Cys Lys Ala Glu 
            180                 185                 190         


Glu Gln Gly Asn Asp Thr Ser Glu Asp Pro Ser Asn Phe Asp Ser Thr 
        195                 200                 205             


Lys Gln Lys Asp Val Trp Asn Asp Pro Glu Cys Ile Ala Leu Val Glu 
    210                 215                 220                 


Leu Val Leu Ser Glu Val Phe Asp Tyr Phe Ile Asp Val Phe Asn Gln 
225                 230                 235                 240 


Asn Ile Glu Pro Leu Pro Thr Ile Gln Lys Asp Ile Thr Ile Lys Leu 
                245                 250                 255     


Arg Glu Met Thr Gln Gln Gly Lys Met Tyr Glu Arg Ala Gln Phe Leu 
            260                 265                 270         


Asn Asp Leu Lys Tyr Glu Asn Asp Tyr Met Phe Asp Gly Thr Thr Thr 
        275                 280                 285             


Ala Lys Thr Ser Pro Ser Asn Ser Pro Glu Ala Ser Pro Ser Leu Ala 
    290                 295                 300                 


Lys Ile Asp Pro Glu Asn Tyr Thr Val Ile Ile Tyr Asn Asp Glu Tyr 
305                 310                 315                 320 


His Asn Tyr Ser Gln Ala Thr Thr Ala Leu Arg Gln Gly Val Pro Asp 
                325                 330                 335     


Asn Val His Ile Asp Leu Leu Thr Ser Arg Ile Asp Gly Glu Gly Arg 
            340                 345                 350         


Ala Met Leu Lys Cys Ser Gln Asp Leu Ser Ser Val Leu Gly Gly Phe 
        355                 360                 365             


Phe Ala Val Gln Thr Asn Gly Leu Ser Ala Thr Leu Thr Ser Trp Ser 
    370                 375                 380                 


Glu Tyr Leu His Gln Glu Ala Cys Lys Tyr Ile Ile Leu Trp Ile Thr 
385                 390                 395                 400 


His Cys Leu Asn Ile Pro Asn Pro Ser Phe Gln Ile Thr Phe Arg Asn 
                405                 410                 415     


Met Met Gly Lys Ser Leu Cys Ser Glu Tyr Leu Asn Ala Thr Glu Ser 
            420                 425                 430         


Arg Asp Met Thr Pro Val Val Glu Lys Tyr Phe Ser Thr Lys Phe Asp 
        435                 440                 445             


Lys Asp Asp Pro Tyr Arg Tyr Ile Asp Leu Ser Val Leu Ala Glu Gly 
    450                 455                 460                 


Asn Gln Ile Pro Leu Gly His His Lys Val Leu Pro Glu Ser Ser Thr 
465                 470                 475                 480 


His Ser Leu Ser Thr Leu Ile Asn Asp Val Glu Asn Leu Thr Ser Lys 
                485                 490                 495     


Glu Tyr Ser Asn Thr Arg Leu Gln His Ile Leu Tyr Phe Asp Asn Arg 
            500                 505                 510         


Tyr Trp Lys Arg Leu Arg Lys Asp Ile Gln Asn Val Ile Ile Pro Thr 
        515                 520                 525             


Leu Ala Ser Ser Thr Leu Tyr Lys Pro Ile Phe Cys Gln Gln Val Val 
    530                 535                 540                 


Glu Ile Phe Asn His Ile Thr Arg Ser Val Ala Tyr Met Asp Arg Glu 
545                 550                 555                 560 


Pro Gln Leu Thr Ala Ile Arg Glu Cys Val Val Gln Leu Phe Thr Cys 
                565                 570                 575     


Pro Thr Asn Thr Arg Asn Ile Phe Glu Asn Gln Ser Phe Leu Asp Ile 
            580                 585                 590         


Leu Trp Ser Ile Ile Asp Ile Phe Lys Glu Phe Cys Lys Val Glu Ala 
        595                 600                 605             


Gly Val Leu Ile Trp Gln Arg Val Gln Lys Ser Asn Leu Thr Lys Ser 
    610                 615                 620                 


Tyr Ser Leu Ser Phe Lys Gln Gly Leu Tyr Thr Val Glu Thr Leu Leu 
625                 630                 635                 640 


Ser Lys Val Asn Asp Pro Asn Ile Thr Ile Arg Pro Lys Val Phe Ile 
                645                 650                 655     


Ser Leu Leu Thr Leu Gly Lys Leu Phe Asn Gly Ala Trp Lys Ile Lys 
            660                 665                 670         


Arg Lys Glu Gly Glu His Val Leu His Glu Asp Gln Asn Phe Ile Ser 
        675                 680                 685             


Tyr Leu Glu Tyr Thr Thr Ser Ile Tyr Ser Ile Ile Gln Thr Ala Glu 
    690                 695                 700                 


Lys Val Leu Glu Lys Ser His Asp Ser Leu Asp Leu Asn Leu Val Leu 
705                 710                 715                 720 


Asn Ala Ile Arg Ile Val Ser Ser Phe Leu Gly Asn Arg Ser Leu Thr 
                725                 730                 735     


Tyr Lys Leu Ile Tyr Asp Ser His Glu Ile Ile Lys Phe Ser Val Ser 
            740                 745                 750         


His Glu Arg Val Ala Phe Met Asn Pro Ile Gln Thr Met Leu Ser Phe 
        755                 760                 765             


Leu Ile Glu Lys Val Ser Leu Lys Asp Ala Tyr Glu Ser Leu Glu Asn 
    770                 775                 780                 


Cys Pro Asp Phe Leu Lys Ile Ala Asp Phe Ser Leu Arg Ser Val Val 
785                 790                 795                 800 


Leu Cys Ser Gln Ile Asp Val Gly Phe Trp Val Arg Asn Gly Met Ser 
                805                 810                 815     


Val Leu His Gln Ala Ser Tyr Tyr Lys Asn Asn Pro Glu Leu Gly Ser 
            820                 825                 830         


Tyr Ser Arg Asp Ile His Leu Asn Gln Leu Ala Ile Ile Trp Glu Arg 
        835                 840                 845             


Asp Asp Leu Pro Arg Val Ile Tyr Asn Ile Leu Asp Arg Trp Glu Leu 
    850                 855                 860                 


Leu Asp Trp Phe Met Gly Glu Ala Glu Tyr Gln His Thr Val Tyr Glu 
865                 870                 875                 880 


Asp Lys Ile Ser Phe Met Ile Gln Gln Phe Ile Ala Phe Ile Tyr Gln 
                885                 890                 895     


Ile Leu Thr Glu Arg Gln Tyr Phe Lys Thr Phe Ser Leu Leu Arg Asp 
            900                 905                 910         


Arg Arg Met Asp Met Ile Lys Asn Ser Ile Met Tyr Asn Leu Tyr Met 
        915                 920                 925             


Lys Pro Leu Ser Tyr Ser Lys Leu Leu Lys Ser Val Pro Asp Tyr Leu 
    930                 935                 940                 


Thr Asp Asp Thr Thr Glu Phe Asp Glu Ala Leu Glu Glu Val Ser Val 
945                 950                 955                 960 


Phe Val Glu Pro Lys Gly Leu Ala Asp Asn Gly Val Phe Lys Leu Lys 
                965                 970                 975     


Ala Ala Leu Tyr Ala Lys Ile Asp Pro Leu Lys Leu Leu Asn Leu Glu 
            980                 985                 990         


Asn Glu Phe Glu Ser Ser Ala Thr  Ile Ile Lys Thr His  Leu Ala Lys 
        995                 1000                 1005             


Asn Lys  Asp Glu Val Ser Lys  Val Val Leu Ile Pro  Gln Val Ser 
    1010                 1015                 1020             


Thr Lys  Leu Leu Asp Lys Gly  Ala Met Asn Leu Gly  Glu Phe Thr 
    1025                 1030                 1035             


Arg Asn  Thr Val Phe Ala Lys  Val Ile Tyr Lys Leu  Leu Gln Val 
    1040                 1045                 1050             


Cys Leu  Asp Met Glu Asp Ser  Thr Phe Leu Asn Glu  Leu Leu His 
    1055                 1060                 1065             


Leu Val  His Gly Ile Phe Lys  Asp Asp Glu Leu Ile  Asn Gly Lys 
    1070                 1075                 1080             


Asp Ser  Ile Pro Glu Ala Tyr  Leu Ala Lys Pro Ile  Cys Asn Leu 
    1085                 1090                 1095             


Leu Leu  Ser Ile Ala Asn Ala  Lys Ser Asp Ile Phe  Ser Glu Ser 
    1100                 1105                 1110             


Ile Val  Arg Lys Ala Asp Tyr  Leu Leu Glu Lys Met  Ile Met Lys 
    1115                 1120                 1125             


Lys Pro  Asp Glu Ile Phe Glu  Ser Leu Ile Ala Ser  Phe Gly Asn 
    1130                 1135                 1140             


Gln Tyr  Ile Asp Asn Tyr Lys  Asp Lys Lys Leu Ser  Gln Gly Val 
    1145                 1150                 1155             


Asn Leu  Gln Glu Thr Glu Lys  Glu Arg Lys Arg Arg  Met Ala Lys 
    1160                 1165                 1170             


Lys His  Gln Ala Arg Leu Leu  Ala Lys Phe Asn Asn  Gln Gln Ser 
    1175                 1180                 1185             


Lys Phe  Met Lys Glu His Glu  Ser Glu Phe Asp Glu  Gln Asp Asn 
    1190                 1195                 1200             


Asp Val  Asp Met Asp Gly Glu  Lys Val Tyr Glu Ser  Glu Asp Phe 
    1205                 1210                 1215             


Thr Cys  Ala Leu Cys Gln Asp  Ser Ser Ser Thr Asp  Phe Phe Val 
    1220                 1225                 1230             


Ile Pro  Ala Tyr His Asp His  Thr Pro Ile Phe Arg  Pro Gly Asn 
    1235                 1240                 1245             


Ile Phe  Asn Pro Arg Glu Phe  Met Ala Lys Trp Asp  Gly Phe Tyr 
    1250                 1255                 1260             


Asn Asp  Asp Asp Lys Gln Ala  Tyr Ile Asp Asp Glu  Val Leu Glu 
    1265                 1270                 1275             


Ser Leu  Lys Glu Asn Gly Thr  Arg Gly Ser Arg Lys  Val Phe Val 
    1280                 1285                 1290             


Ser Cys  Asn His His Ile His  His Asn Cys Phe Lys  Arg Tyr Val 
    1295                 1300                 1305             


Gln Lys  Lys Arg Phe Ser Ser  Asn Ala Phe Ile Cys  Pro Leu Cys 
    1310                 1315                 1320             


Gln Thr  Phe Ser Asn Cys Thr  Leu Pro Ile Cys Pro  Thr Ser Arg 
    1325                 1330                 1335             


Ala Asn  Thr Gly Leu Ser Leu  Asp Met Phe Leu Lys  Ser Glu Leu 
    1340                 1345                 1350             


Ser Leu  Asp Ile Leu Ser Arg  Leu Phe Lys Pro Phe  Thr Glu Asp 
    1355                 1360                 1365             


Asn Tyr  Arg Thr Ile Asn Ser  Ile Phe Ser Leu Met  Val Ser Gln 
    1370                 1375                 1380             


Cys Gln  Gly Phe Asp Lys Val  Val Arg Lys His Val  Asn Phe Thr 
    1385                 1390                 1395             


His Lys  Asp Val Ser Leu Val  Leu Ser Val His Trp  Ala Asn Thr 
    1400                 1405                 1410             


Ile Ser  Met Leu Glu Val Ala  Ser Arg Leu Glu Lys  Pro His Asn 
    1415                 1420                 1425             


Ile Ser  Phe Phe Arg Ser Arg  Glu Gln Lys Tyr Lys  Thr Leu Lys 
    1430                 1435                 1440             


Asn Ile  Leu Ile Cys Ile Met  Leu Phe Thr Phe Val  Ile Gly Lys 
    1445                 1450                 1455             


Pro Ser  Met Glu Phe Glu Pro  Tyr Pro Val Glu Ser  Asp Ile Ile 
    1460                 1465                 1470             


Cys Asn  Gln Asn Gln Leu Phe  Gln Tyr Ile Val Arg  Lys Ser Leu 
    1475                 1480                 1485             


Phe Ser  Pro Ala Ser Leu Arg  Glu Thr Ile Thr Glu  Ala Leu Thr 
    1490                 1495                 1500             


Val Phe  Cys Lys Gln Phe Leu  Asp Asp Phe Val Gln  Gly Leu Ser 
    1505                 1510                 1515             


Asp Ala  Glu Gln Val Asp Lys  Leu Tyr Thr Glu Ala  Lys Lys Leu 
    1520                 1525                 1530             


Gly Asp  Val Tyr Asn Val Asp  Glu Ser Ile Leu Ile  Thr Leu Met 
    1535                 1540                 1545             


Ser Ile  Thr Val Val Lys Thr  Glu Gly Leu Glu Ser  Arg Ser Ile 
    1550                 1555                 1560             


Tyr Asp  Leu Ala Tyr Thr Ser  Leu Leu Lys Ser Leu  Leu Pro Thr 
    1565                 1570                 1575             


Ile Arg  Arg Cys Leu Val Met  Val Lys Val Leu His  Glu Leu Val 
    1580                 1585                 1590             


Lys Asp  Ser Glu Asn Glu Thr  Met Val Ile Asp Gly  Phe Asp Val 
    1595                 1600                 1605             


Glu Glu  Glu Leu Glu Phe Glu  Gly Leu Pro Gly Phe  Val Asp Lys 
    1610                 1615                 1620             


Ala Leu  Lys Leu Ile Thr Asp  Lys Glu Ser Phe Val  Asp Leu Phe 
    1625                 1630                 1635             


Lys Thr  Lys Gln Ala Ile Val  Pro Ser His Pro Tyr  Leu Glu Arg 
    1640                 1645                 1650             


Ile Pro  Tyr Glu Tyr Cys Gly  Ile Val Lys Leu Ile  Asp Leu Ser 
    1655                 1660                 1665             


Lys Phe  Leu Asn Thr Tyr Val  Thr Gln Ser Lys Glu  Ile Lys Leu 
    1670                 1675                 1680             


Arg Glu  Glu Arg Ser Gln His  Met Lys Asn Ala Asp  Asn Arg Leu 
    1685                 1690                 1695             


Asp Phe  Lys Ile Cys Leu Thr  Cys Gly Val Lys Val  His Leu Arg 
    1700                 1705                 1710             


Ala Asp  Arg His Glu Met Thr  Lys His Leu Asn Lys  Asn Cys Phe 
    1715                 1720                 1725             


Lys Ser  Phe Gly Ala Phe Leu  Met Pro Asn Ser Ser  Glu Val Cys 
    1730                 1735                 1740             


Leu His  Leu Thr Gln Pro Pro  Ser Asn Ile Phe Val  Ser Ala Pro 
    1745                 1750                 1755             


Tyr Leu  Asn Ser His Gly Glu  Val Gly Arg Asn Ala  Met Arg Arg 
    1760                 1765                 1770             


Gly Asp  Leu Thr Thr Leu Asn  Leu Lys Arg Tyr Glu  His Leu Asn 
    1775                 1780                 1785             


Arg Leu  Trp Ile Asn Asn Glu  Ile Pro Gly Tyr Ile  Ser Arg Val 
    1790                 1795                 1800             


Met Gly  Asp Glu Phe Arg Val  Thr Ile Leu Ser Asn  Gly Phe Leu 
    1805                 1810                 1815             


Phe Ala  Phe Asn Arg Glu Pro  Arg Pro Arg Arg Val  Pro Pro Thr 
    1820                 1825                 1830             


Asp Glu  Asp Asp Glu Asp Met  Glu Glu Gly Glu Glu  Gly Phe Phe 
    1835                 1840                 1845             


Thr Glu  Glu Asn Asp Asp Met  Asp Val Asp Asp Glu  Thr Gly Gln 
    1850                 1855                 1860             


Ala Ala  Asn Leu Phe Gly Val  Gly Ala Glu Gly Ile  Gly Asp Gly 
    1865                 1870                 1875             


Gly Val  Arg Asn Phe Phe Gln  Phe Phe Glu Asn Phe  Arg Asn Thr 
    1880                 1885                 1890             


Leu Gln  Pro Gln Gly Asn Asp  Asp Glu Asp Ala Pro  Gln Asn Pro 
    1895                 1900                 1905             


Pro Pro  Ile Leu Gln Phe Leu  Gly Pro Gln Phe Asp  Gly Ala Thr 
    1910                 1915                 1920             


Ile Ile  Arg Asn Thr Asn Gln  Arg Asn Leu Asp Glu  Asp Asp Ser 
    1925                 1930                 1935             


Ser Glu  Asn Asp Asp Ser Asp  Glu Arg Glu Ile Trp  
    1940                 1945                 1950 


<210>  43
<211>  601
<212>  PRT
<213>  Hybrid yeast 1

<400>  43

Met Leu Asn His Pro Ser Gln Gly Ser Asp Asp Ala Gln Asp Glu Lys 
1               5                   10                  15      


Gln Gly Asp Phe Pro Val Ile Glu Glu Glu Lys Thr Gln Ala Val Met 
            20                  25                  30          


Leu Lys Asp Ser Tyr Val Ser Asp Asp Val Ala Asn Ser Thr Glu Arg 
        35                  40                  45              


Tyr Asn Leu Ser Pro Ser Pro Glu Asp Glu Asp Phe Glu Ala Pro Thr 
    50                  55                  60                  


Glu Glu Glu Met Gln Thr Leu Arg His Val Gly Gly Lys Ile Pro Met 
65                  70                  75                  80  


Arg Cys Trp Leu Ile Ala Ile Val Glu Leu Ser Glu Arg Phe Ser Tyr 
                85                  90                  95      


Tyr Gly Leu Ser Ala Pro Phe Gln Asn Tyr Met Glu Tyr Gly Pro Asn 
            100                 105                 110         


Asp Ser Pro Lys Gly Val Leu Ser Leu Asn Ser Gln Gly Ala Thr Gly 
        115                 120                 125             


Leu Ser Tyr Phe Phe Gln Phe Trp Cys Tyr Val Thr Pro Val Phe Gly 
    130                 135                 140                 


Gly Tyr Val Ala Asp Thr Phe Trp Gly Lys Tyr Asn Thr Ile Cys Cys 
145                 150                 155                 160 


Gly Thr Ala Ile Tyr Ile Ala Gly Ile Phe Ile Leu Phe Ile Thr Ser 
                165                 170                 175     


Ile Pro Ser Val Gly Asn Arg Asp Ser Ala Ile Gly Gly Phe Ile Ala 
            180                 185                 190         


Ala Ile Ile Leu Ile Gly Ile Ala Thr Gly Met Ile Lys Ala Asn Leu 
        195                 200                 205             


Ser Val Leu Ile Ala Asp Gln Leu Pro Lys Arg Lys Pro Ser Ile Lys 
    210                 215                 220                 


Val Leu Lys Ser Gly Glu Arg Val Ile Val Asp Ser Asn Ile Thr Leu 
225                 230                 235                 240 


Gln Asn Val Phe Met Phe Phe Tyr Phe Met Ile Asn Val Gly Ser Leu 
                245                 250                 255     


Ser Leu Met Ala Thr Thr Glu Leu Glu Tyr His Lys Gly Phe Trp Ala 
            260                 265                 270         


Ala Tyr Leu Leu Pro Phe Cys Phe Phe Trp Ile Ala Val Val Thr Leu 
        275                 280                 285             


Ile Phe Gly Lys Lys Gln Tyr Ile Gln Arg Pro Ile Gly Asp Lys Val 
    290                 295                 300                 


Ile Ala Lys Ser Phe Lys Val Cys Trp Ile Leu Thr Lys Asn Lys Phe 
305                 310                 315                 320 


Asp Phe Asn Ala Ala Lys Pro Ser Val His Pro Glu Lys Asn Tyr Pro 
                325                 330                 335     


Trp Asn Asp Lys Phe Val Asp Glu Ile Lys Arg Ala Leu Ala Ala Cys 
            340                 345                 350         


Lys Val Phe Ile Phe Tyr Pro Ile Tyr Trp Thr Gln Tyr Gly Thr Met 
        355                 360                 365             


Ile Ser Ser Phe Ile Thr Gln Ala Ser Met Met Glu Leu His Gly Ile 
    370                 375                 380                 


Pro Asn Asp Phe Leu Gln Ala Phe Asp Ser Ile Ala Leu Ile Ile Phe 
385                 390                 395                 400 


Ile Pro Ile Phe Glu Lys Phe Val Tyr Pro Phe Ile Arg Arg Tyr Thr 
                405                 410                 415     


Pro Leu Lys Pro Ile Thr Lys Ile Phe Val Gly Phe Met Phe Gly Ser 
            420                 425                 430         


Phe Ala Met Thr Trp Ala Ala Val Leu Gln Ser Phe Val Tyr Lys Ala 
        435                 440                 445             


Gly Pro Trp Tyr Asn Glu Pro Leu Gly His Asn Thr Pro Asn His Val 
    450                 455                 460                 


His Val Cys Trp Gln Ile Pro Ala Tyr Val Leu Ile Ser Phe Ser Glu 
465                 470                 475                 480 


Ile Phe Ala Ser Ile Thr Gly Leu Glu Tyr Ala Tyr Ser Lys Ala Pro 
                485                 490                 495     


Ala Ser Met Lys Ser Phe Ile Met Ser Ile Phe Leu Leu Thr Asn Ala 
            500                 505                 510         


Phe Gly Ser Ala Ile Gly Cys Ala Leu Ser Pro Val Thr Val Asp Pro 
        515                 520                 525             


Lys Phe Thr Trp Leu Phe Thr Gly Leu Ala Val Ala Cys Phe Ile Ser 
    530                 535                 540                 


Gly Cys Leu Phe Trp Leu Cys Phe Arg Lys Tyr Asn Asp Thr Glu Glu 
545                 550                 555                 560 


Glu Met Asn Ala Met Asp Tyr Glu Glu Glu Asn Glu Phe Asp Leu Asn 
                565                 570                 575     


Pro Ile Ser Ala Pro Lys Ala Asn Asp Ile Glu Ile Leu Glu Pro Met 
            580                 585                 590         


Asp Ser Leu Arg Ser Thr Thr Lys Tyr 
        595                 600     


<210>  44
<211>  601
<212>  PRT
<213>  Hybrid yeast 1

<400>  44

Met Leu Asn His Leu Ser Gln Gly Ser Asp Asp Ile Gln Asp Glu Lys 
1               5                   10                  15      


Gln Gly Asp Phe Pro Val Ile Glu Glu Glu Lys Asn Gln Thr Val Thr 
            20                  25                  30          


Leu Lys Asp Ser Tyr Val Ser Asp Asp Ala Ala Asn Ser Thr Glu His 
        35                  40                  45              


Tyr Asn Leu Ser Pro Ser Leu Glu Glu Asp Glu Phe Glu Ala Pro Thr 
    50                  55                  60                  


Asp Glu Glu Leu Arg Ser Leu Arg His Val Gly Gly Lys Ile Pro Met 
65                  70                  75                  80  


Arg Cys Trp Leu Ile Ala Ile Val Glu Leu Ser Glu Arg Phe Ser Tyr 
                85                  90                  95      


Tyr Gly Leu Ser Ala Pro Phe Gln Asn Tyr Met Glu Tyr Gly Pro Lys 
            100                 105                 110         


Asp Thr Pro Lys Gly Val Leu Ser Leu Asn Ser Gln Gly Ala Thr Gly 
        115                 120                 125             


Leu Ser Tyr Phe Phe Gln Phe Trp Cys Tyr Val Thr Pro Val Phe Gly 
    130                 135                 140                 


Gly Tyr Val Ala Asp Thr Phe Trp Gly Lys Tyr Asn Thr Ile Cys Cys 
145                 150                 155                 160 


Gly Thr Ala Ile Tyr Ile Ala Gly Ile Phe Ile Leu Leu Ile Thr Ser 
                165                 170                 175     


Ile Pro Ser Val Gly Asn Arg Asp Ser Ala Leu Gly Gly Phe Ile Ala 
            180                 185                 190         


Ser Ile Ile Leu Ile Gly Ile Ala Thr Gly Met Ile Lys Ala Asn Leu 
        195                 200                 205             


Ser Val Leu Ile Ala Asp Gln Leu Pro Lys Arg Lys Pro Ser Ile Lys 
    210                 215                 220                 


Val Leu Lys Ser Gly Glu Arg Val Ile Val Asp Ser Asn Ile Thr Leu 
225                 230                 235                 240 


Gln Asn Val Phe Met Phe Phe Tyr Phe Met Ile Asn Val Gly Ser Leu 
                245                 250                 255     


Ser Leu Met Ala Thr Thr Glu Leu Glu Tyr His Lys Gly Phe Trp Ala 
            260                 265                 270         


Ala Tyr Leu Leu Pro Phe Cys Phe Phe Trp Val Ala Val Val Thr Leu 
        275                 280                 285             


Val Phe Gly Lys Lys Gln Tyr Ile Gln Arg Pro Ile Gly Asp Lys Val 
    290                 295                 300                 


Ile Ala Lys Ser Phe Arg Val Cys Trp Ile Leu Thr Lys Asn Lys Phe 
305                 310                 315                 320 


Asp Phe Asn Ala Ala Lys Pro Ser Val His Pro Glu Lys Glu Tyr Pro 
                325                 330                 335     


Trp Asn Asp Lys Phe Val Asp Glu Ile Lys Arg Ala Leu Ala Ala Cys 
            340                 345                 350         


Lys Val Phe Val Phe Tyr Pro Ile Tyr Trp Thr Gln Tyr Gly Thr Met 
        355                 360                 365             


Ile Ser Ser Phe Ile Thr Gln Ala Gly Met Met Glu Leu His Gly Ile 
    370                 375                 380                 


Pro Asn Asp Phe Leu Gln Ala Phe Asp Ser Ile Ala Leu Ile Ile Phe 
385                 390                 395                 400 


Ile Pro Ile Phe Glu Lys Phe Ile Tyr Pro Phe Ile Arg Arg Tyr Thr 
                405                 410                 415     


Pro Phe Lys Pro Ile Thr Lys Ile Phe Phe Gly Phe Met Phe Gly Ser 
            420                 425                 430         


Leu Ala Met Thr Trp Ala Ala Val Leu Gln Ser Phe Val Tyr Lys Ala 
        435                 440                 445             


Gly Pro Trp Tyr Ser Ala Pro Leu Gly His Asn Thr Pro Asn His Val 
    450                 455                 460                 


His Val Cys Trp Gln Ile Pro Ala Tyr Val Leu Ile Ser Phe Ser Glu 
465                 470                 475                 480 


Ile Phe Ala Ser Ile Thr Gly Leu Glu Tyr Ala Tyr Ser Lys Ala Pro 
                485                 490                 495     


Ala Ser Met Lys Ser Phe Ile Met Ser Ile Phe Leu Leu Thr Asn Ala 
            500                 505                 510         


Phe Gly Ser Ala Ile Gly Cys Ala Leu Ser Pro Val Thr Val Asp Pro 
        515                 520                 525             


Lys Phe Thr Trp Leu Phe Thr Gly Leu Ala Val Ala Cys Phe Ile Ser 
    530                 535                 540                 


Gly Cys Leu Phe Trp Phe Cys Phe Arg Lys Tyr Asn Asp Thr Glu Glu 
545                 550                 555                 560 


Glu Met Asn Ala Met Asp Tyr Glu Glu Glu Asp Glu Phe Asp Leu Asn 
                565                 570                 575     


Pro Ile Ser Gln Pro Lys Gly Asn Asp Ile Glu Ile Leu Glu Pro Met 
            580                 585                 590         


Gly Ser Leu Lys Ser Thr Thr Lys Tyr 
        595                 600     


<210>  45
<211>  361
<212>  PRT
<213>  Hybrid yeast 1

<400>  45

Met Ser Val Ala Asp Asp Asp Leu Gly Ser Leu Gln Gly His Ile Arg 
1               5                   10                  15      


Arg Thr Leu Arg Ser Ile His Asn Leu Pro Tyr Phe Arg Tyr Thr Arg 
            20                  25                  30          


Gly Pro Thr Glu Arg Ala Asp Met Ser Arg Ala Leu Lys Glu Phe Ile 
        35                  40                  45              


Tyr Arg Tyr Leu Tyr Phe Val Ile Ser Asn Ser Gly Glu Asn Leu Pro 
    50                  55                  60                  


Thr Leu Phe Asn Ala His Pro Lys Gln Lys Leu Ser Asn Pro Glu Leu 
65                  70                  75                  80  


Thr Val Phe Pro Asp Ser Leu Glu Asp Ala Val Asp Ile Asp Lys Ile 
                85                  90                  95      


Thr Ser Gln Gln Thr Ile Pro Phe Tyr Lys Ile Asp Glu Ser Arg Ile 
            100                 105                 110         


Gly Asp Val His Lys His Thr Gly Arg Asn Cys Gly Arg Lys Phe Lys 
        115                 120                 125             


Ile Gly Glu Pro Leu Tyr Arg Cys His Glu Cys Gly Cys Asp Asp Thr 
    130                 135                 140                 


Cys Val Leu Cys Ile His Cys Phe Asn Pro Lys Asp His Val Asn His 
145                 150                 155                 160 


His Val Cys Thr Asp Ile Cys Thr Glu Phe Thr Ser Gly Ile Cys Asp 
                165                 170                 175     


Cys Gly Asp Glu Glu Ala Trp Asn Ser Pro Leu His Cys Lys Ala Glu 
            180                 185                 190         


Glu Gln Glu Asn Asp Ile Ser Glu Asp Pro Ala Thr Asn Ala Asp Ile 
        195                 200                 205             


Lys Glu Glu Asp Val Trp Asn Asp Ser Val Asn Ile Ala Leu Val Glu 
    210                 215                 220                 


Leu Val Leu Ala Glu Val Phe Asp Tyr Phe Ile Asp Val Phe Asn Gln 
225                 230                 235                 240 


Asn Ile Glu Pro Leu Pro Thr Ile Gln Lys Asp Ile Thr Ile Lys Leu 
                245                 250                 255     


Arg Glu Met Thr Gln Gln Gly Lys Met Tyr Glu Arg Ala Gln Phe Leu 
            260                 265                 270         


Asn Asp Leu Lys Tyr Glu Asn Asp Tyr Met Phe Asp Gly Thr Thr Thr 
        275                 280                 285             


Ala Lys Thr Ser Pro Ser Asn Ser Pro Glu Ala Ser Pro Ser Leu Ala 
    290                 295                 300                 


Lys Ile Asp Pro Glu Asn Tyr Thr Val Ile Ile Tyr Asn Asp Glu Tyr 
305                 310                 315                 320 


His Asn Tyr Ser Gln Ala Thr Thr Ala Leu Arg Gln Gly Val Pro Asp 
                325                 330                 335     


Asn Val His Ile Asp Leu Leu Thr Ser Arg Ile Asp Gly Glu Gly Arg 
            340                 345                 350         


Ala Met Leu Lys Cys Ser Gln Asp Leu 
        355                 360     


