                         SEQUENCE LISTING

<110>  The Brigham and Women's Hospital, Inc. 
 
<120>  USE OF CADHERIN-11 ANTAGONISTS TO TREAT OBESITY-ASSOCIATED CONDITIONS AND OTHER METABOLIC DISORDERS

<130>  B0801.70381WO00

<140>  Not Yet Assigned
<141>  2015-12-15

<150>  US 62/091709
<151>  2014-12-15

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  3654
<212>  DNA
<213>  H. sapiens

<400>  1
agatgccgcg ggggccgctc gcagccgccg ctgacttgtg aatgggaccg ggactggggc       60

cgggactgac accgcagcgc ttgccctgcg ccagggactg gcggctcgga ggttgcgtcc      120

accctcaagg gccccagaaa tcactgtgtt ttcagctcag cggccctgtg acattccttc      180

gtgttgtcat ttgttgagtg accaatcaga tgggtggagt gtgttacaga aattggcagc      240

aagtatccaa tgggtgaaga agaagctaac tggggacgtg ggcagccctg acgtgatgag      300

ctcaaccagc agagacattc catcccaaga gaggtctgcg tgacgcgtcc gggaggccac      360

cctcagcaag accaccgtac agttggtgga aggggtgaca gctgcattct cctgtgccta      420

ccacgtaacc aaaaatgaag gagaactact gtttacaagc cgccctggtg tgcctgggca      480

tgctgtgcca cagccatgcc tttgccccag agcggcgggg gcacctgcgg ccctccttcc      540

atgggcacca tgagaagggc aaggaggggc aggtgctaca gcgctccaag cgtggctggg      600

tctggaacca gttcttcgtg atagaggagt acaccgggcc tgaccccgtg cttgtgggca      660

ggcttcattc agatattgac tctggtgatg ggaacattaa atacattctc tcaggggaag      720

gagctggaac catttttgtg attgatgaca aatcagggaa cattcatgcc accaagacgt      780

tggatcgaga agagagagcc cagtacacgt tgatggctca ggcggtggac agggacacca      840

atcggccact ggagccaccg tcggaattca ttgtcaaggt ccaggacatt aatgacaacc      900

ctccggagtt cctgcacgag acctatcatg ccaacgtgcc tgagaggtcc aatgtgggaa      960

cgtcagtaat ccaggtgaca gcttcagatg cagatgaccc cacttatgga aatagcgcca     1020

agttagtgta cagtatcctc gaaggacaac cctatttttc ggtggaagca cagacaggta     1080

tcatcagaac agccctaccc aacatggaca gggaggccaa ggaggagtac cacgtggtga     1140

tccaggccaa ggacatgggt ggacatatgg gcggactctc agggacaacc aaagtgacga     1200

tcacactgac cgatgtcaat gacaacccac caaagtttcc gcagagcgta taccagatgt     1260

ctgtgtcaga agcagccgtc cctggggagg aagtaggaag agtgaaagct aaagatccag     1320

acattggaga aaatggctta gtcacataca atattgttga tggagatggt atggaatcgt     1380

ttgaaatcac aacggactat gaaacacagg agggggtgat aaagctgaaa aagcctgtag     1440

attttgaaac caaaagagcc tatagcttga aggtagaggc agccaacgtg cacatcgacc     1500

cgaagtttat cagcaatggc cctttcaagg acactgtgac cgtcaagatc tcagtagaag     1560

atgctgatga gccccctatg ttcttggccc caagttacat ccacgaagtc caagaaaatg     1620

cagctgctgg caccgtggtt gggagagtgc atgccaaaga ccctgatgct gccaacagcc     1680

cgataaggta ttccatcgat cgtcacactg acctcgacag atttttcact attaatccag     1740

aggatggttt tattaaaact acaaaacctc tggatagaga ggaaacagcc tggctcaaca     1800

tcactgtctt tgcagcagaa atccacaatc ggcatcagga agccaaagtc ccagtggcca     1860

ttagggtcct tgatgtcaac gataatgctc ccaagtttgc tgccccttat gaaggtttca     1920

tctgtgagag tgatcagacc aagccacttt ccaaccagcc aattgttaca attagtgcag     1980

atgacaagga tgacacggcc aatggaccaa gatttatctt cagcctaccc cctgaaatca     2040

ttcacaatcc aaatttcaca gtcagagaca accgagataa cacagcaggc gtgtacgccc     2100

ggcgtggagg gttcagtcgg cagaagcagg acttgtacct tctgcccata gtgatcagcg     2160

atggcggcat cccgcccatg agtagcacca acaccctcac catcaaagtc tgcgggtgcg     2220

acgtgaacgg ggcactgctc tcctgcaacg cagaggccta cattctgaac gccggcctga     2280

gcacaggcgc cctgatcgcc atcctcgcct gcatcgtcat tctcctggtc attgtagtat     2340

tgtttgtgac cctgagaagg caaaagaaag aaccactcat tgtctttgag gaagaagatg     2400

tccgtgagaa catcattact tatgatgatg aagggggtgg ggaagaagac acagaagcct     2460

ttgatattgc caccctccag aatcctgatg gtatcaatgg atttatcccc cgcaaagaca     2520

tcaaacctga gtatcagtac atgcctagac ctgggctccg gccagcgccc aacagcgtgg     2580

atgtcgatga cttcatcaac acgagaatac aggaggcaga caatgacccc acggctcctc     2640

cttatgactc cattcaaatc tacggttatg aaggcagggg ctcagtggcc gggtccctga     2700

gctccctaga gtcggccacc acagattcag acttggacta tgattatcta cagaactggg     2760

gacctcgttt taagaaacta gcagatttgt atggttccaa agacactttt gatgacgatt     2820

cttaacaata acgatacaaa tttggcctta agaactgtgt ctggcgttct caagaatcta     2880

gaagatgtgt aaacaggtat ttttttaaat caaggaaagg ctcatttaaa acaggcaaag     2940

ttttacagag aggatacatt taataaaact gcgaggacat caaagtggta aatactgtga     3000

aatacctttt ctcacaaaaa ggcaaatatt gaagttgttt atcaacttcg ctagaaaaaa     3060

aaaacacttg gcatacaaaa tatttaagtg aaggagaagt ctaacgctga actgacaatg     3120

aagggaaatt gtttatgtgt tatgaacatc caagtctttc ttctttttta agttgtcaaa     3180

gaagcttcca caaaattaga aaggacaaca gttctgagct gtaatttcgc cttaaactct     3240

ggacactcta tatgtagtgc atttttaaac ttgaaatata taatattcag ccagcttaaa     3300

cccatacaat gtatgtacaa tacaatgtac aattatgtct cttgagcatc aatcttgtta     3360

ctgctgattc ttgtaaatct ttttgcttct actttcatct taaactaata cgtgccagat     3420

ataactgtct tgtttcagtg agagacgccc tatttctatg tcatttttaa tgtatctatt     3480

tgtacaattt taaagttctt attttagtat acgtataaat atcagtattc tgacatgtaa     3540

gaaaatgtta cggcatcaca cttatatttt atgaacattg tactgttgct ttaatatgag     3600

cttcaatata agaagcaatc tttgaaataa aaaaagattt ttttttaaaa aaaa           3654


<210>  2
<211>  796
<212>  PRT
<213>  H. sapiens

<400>  2

Met Lys Glu Asn Tyr Cys Leu Gln Ala Ala Leu Val Cys Leu Gly Met 
1               5                   10                  15      


Leu Cys His Ser His Ala Phe Ala Pro Glu Arg Arg Gly His Leu Arg 
            20                  25                  30          


Pro Ser Phe His Gly His His Glu Lys Gly Lys Glu Gly Gln Val Leu 
        35                  40                  45              


Gln Arg Ser Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Ile Glu 
    50                  55                  60                  


Glu Tyr Thr Gly Pro Asp Pro Val Leu Val Gly Arg Leu His Ser Asp 
65                  70                  75                  80  


Ile Asp Ser Gly Asp Gly Asn Ile Lys Tyr Ile Leu Ser Gly Glu Gly 
                85                  90                  95      


Ala Gly Thr Ile Phe Val Ile Asp Asp Lys Ser Gly Asn Ile His Ala 
            100                 105                 110         


Thr Lys Thr Leu Asp Arg Glu Glu Arg Ala Gln Tyr Thr Leu Met Ala 
        115                 120                 125             


Gln Ala Val Asp Arg Asp Thr Asn Arg Pro Leu Glu Pro Pro Ser Glu 
    130                 135                 140                 


Phe Ile Val Lys Val Gln Asp Ile Asn Asp Asn Pro Pro Glu Phe Leu 
145                 150                 155                 160 


His Glu Thr Tyr His Ala Asn Val Pro Glu Arg Ser Asn Val Gly Thr 
                165                 170                 175     


Ser Val Ile Gln Val Thr Ala Ser Asp Ala Asp Asp Pro Thr Tyr Gly 
            180                 185                 190         


Asn Ser Ala Lys Leu Val Tyr Ser Ile Leu Glu Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Glu Ala Gln Thr Gly Ile Ile Arg Thr Ala Leu Pro Asn Met 
    210                 215                 220                 


Asp Arg Glu Ala Lys Glu Glu Tyr His Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Gly Gly His Met Gly Gly Leu Ser Gly Thr Thr Lys Val Thr Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Lys Phe Pro Gln Ser Val 
            260                 265                 270         


Tyr Gln Met Ser Val Ser Glu Ala Ala Val Pro Gly Glu Glu Val Gly 
        275                 280                 285             


Arg Val Lys Ala Lys Asp Pro Asp Ile Gly Glu Asn Gly Leu Val Thr 
    290                 295                 300                 


Tyr Asn Ile Val Asp Gly Asp Gly Met Glu Ser Phe Glu Ile Thr Thr 
305                 310                 315                 320 


Asp Tyr Glu Thr Gln Glu Gly Val Ile Lys Leu Lys Lys Pro Val Asp 
                325                 330                 335     


Phe Glu Thr Lys Arg Ala Tyr Ser Leu Lys Val Glu Ala Ala Asn Val 
            340                 345                 350         


His Ile Asp Pro Lys Phe Ile Ser Asn Gly Pro Phe Lys Asp Thr Val 
        355                 360                 365             


Thr Val Lys Ile Ser Val Glu Asp Ala Asp Glu Pro Pro Met Phe Leu 
    370                 375                 380                 


Ala Pro Ser Tyr Ile His Glu Val Gln Glu Asn Ala Ala Ala Gly Thr 
385                 390                 395                 400 


Val Val Gly Arg Val His Ala Lys Asp Pro Asp Ala Ala Asn Ser Pro 
                405                 410                 415     


Ile Arg Tyr Ser Ile Asp Arg His Thr Asp Leu Asp Arg Phe Phe Thr 
            420                 425                 430         


Ile Asn Pro Glu Asp Gly Phe Ile Lys Thr Thr Lys Pro Leu Asp Arg 
        435                 440                 445             


Glu Glu Thr Ala Trp Leu Asn Ile Thr Val Phe Ala Ala Glu Ile His 
    450                 455                 460                 


Asn Arg His Gln Glu Ala Lys Val Pro Val Ala Ile Arg Val Leu Asp 
465                 470                 475                 480 


Val Asn Asp Asn Ala Pro Lys Phe Ala Ala Pro Tyr Glu Gly Phe Ile 
                485                 490                 495     


Cys Glu Ser Asp Gln Thr Lys Pro Leu Ser Asn Gln Pro Ile Val Thr 
            500                 505                 510         


Ile Ser Ala Asp Asp Lys Asp Asp Thr Ala Asn Gly Pro Arg Phe Ile 
        515                 520                 525             


Phe Ser Leu Pro Pro Glu Ile Ile His Asn Pro Asn Phe Thr Val Arg 
    530                 535                 540                 


Asp Asn Arg Asp Asn Thr Ala Gly Val Tyr Ala Arg Arg Gly Gly Phe 
545                 550                 555                 560 


Ser Arg Gln Lys Gln Asp Leu Tyr Leu Leu Pro Ile Val Ile Ser Asp 
                565                 570                 575     


Gly Gly Ile Pro Pro Met Ser Ser Thr Asn Thr Leu Thr Ile Lys Val 
            580                 585                 590         


Cys Gly Cys Asp Val Asn Gly Ala Leu Leu Ser Cys Asn Ala Glu Ala 
        595                 600                 605             


Tyr Ile Leu Asn Ala Gly Leu Ser Thr Gly Ala Leu Ile Ala Ile Leu 
    610                 615                 620                 


Ala Cys Ile Val Ile Leu Leu Val Ile Val Val Leu Phe Val Thr Leu 
625                 630                 635                 640 


Arg Arg Gln Lys Lys Glu Pro Leu Ile Val Phe Glu Glu Glu Asp Val 
                645                 650                 655     


Arg Glu Asn Ile Ile Thr Tyr Asp Asp Glu Gly Gly Gly Glu Glu Asp 
            660                 665                 670         


Thr Glu Ala Phe Asp Ile Ala Thr Leu Gln Asn Pro Asp Gly Ile Asn 
        675                 680                 685             


Gly Phe Ile Pro Arg Lys Asp Ile Lys Pro Glu Tyr Gln Tyr Met Pro 
    690                 695                 700                 


Arg Pro Gly Leu Arg Pro Ala Pro Asn Ser Val Asp Val Asp Asp Phe 
705                 710                 715                 720 


Ile Asn Thr Arg Ile Gln Glu Ala Asp Asn Asp Pro Thr Ala Pro Pro 
                725                 730                 735     


Tyr Asp Ser Ile Gln Ile Tyr Gly Tyr Glu Gly Arg Gly Ser Val Ala 
            740                 745                 750         


Gly Ser Leu Ser Ser Leu Glu Ser Ala Thr Thr Asp Ser Asp Leu Asp 
        755                 760                 765             


Tyr Asp Tyr Leu Gln Asn Trp Gly Pro Arg Phe Lys Lys Leu Ala Asp 
    770                 775                 780                 


Leu Tyr Gly Ser Lys Asp Thr Phe Asp Asp Asp Ser 
785                 790                 795     


<210>  3
<211>  34
<212>  PRT
<213>  H. sapiens

<400>  3

Gly Trp Val Trp Asn Gln Phe Phe Val Ile Glu Glu Tyr Thr Gly Pro 
1               5                   10                  15      


Asp Pro Val Leu Val Gly Arg Leu His Ser Asp Ile Asp Ser Gly Asp 
            20                  25                  30          


Gly Asn 
        


<210>  4
<211>  21
<212>  RNA
<213>  artificial sequence

<220>
<223>  human Cdh11 siRNA

<400>  4
uuugaaugga gucauaaggu u                                                 21


