               SEQUENCE LISTING

<110> Charité Universitätsmedizin Berlin

<120> Methods for the detection of antibodies against members of the cardiac receptor family

<130> C1452DG WO

<150> DE102014226663.7
<151> 2014-12-19

<160> 24

<170> BiSSAP 1.3.2

<210> 1
<211> 1653
<212> DNA
<213> Photinus pyralis


<400> 1
gtcaccgacg ccaaaaacat aaagaaaggc ccggcgccat tctatccgct ggaagatgga      60

accgctggag agcaactgca taaggctatg aagagatacg ccctggttcc tggaacaatt     120

gcttttacag atgcacatat cgaggtggac atcacttacg ctgagtactt cgaaatgtcc     180

gttcggttgg cagaagctat gaaacgatat gggctgaata caaatcacag aatcgtcgta     240

tgcagtgaaa actctcttca attctttatg ccggtgttgg gcgcgttatt tatcggagtt     300

gcagttgcgc ccgcgaacga catttataat gaacgtgaat tgctcaacag tatgggcatt     360

tcgcagccta ccgtggtgtt cgtttccaaa aaggggttgc aaaaaatttt gaacgtgcaa     420

aaaaagctcc caatcatcca aaaaattatt atcatggatt ctaaaacgga ttaccaggga     480

tttcagtcga tgtacacgtt cgtcacatct catctacctc ccggttttaa tgaatacgat     540

tttgtgccag agtccttcga tagggacaag acaattgcac tgatcatgaa ctcctctgga     600

tctactggtc tgcctaaagg tgtcgctctg cctcatagaa ctgcctgcgt gagattctcg     660

catgccagag atcctatttt tggcaatcaa atcattccgg atactgcgat tttaagtgtt     720

gttccattcc atcacggttt tggaatgttt actacactcg gatatttgat atgtggattt     780

cgagtcgtct taatgtatag atttgaagaa gagctgtttc tgaggagcct tcaggattac     840

aagattcaaa gtgcgctgct ggtgccaacc ctattctcct tcttcgccaa aagcactctg     900

attgacaaat acgatttatc taatttacac gaaattgctt ctggtggcgc tcccctctct     960

aaggaagtcg gggaagcggt tgccaagagg ttccatctgc caggtatcag gcaaggatat    1020

gggctcactg agactacatc agctattctg attacacccg agggggatga taaaccgggc    1080

gcggtcggta aagttgttcc attttttgaa gcgaaggttg tggatctgga taccgggaaa    1140

acgctgggcg ttaatcaaag aggcgaactg tgtgtgagag gtcctatgat tatgtccggt    1200

tatgtaaaca atccggaagc gaccaacgcc ttgattgaca aggatggatg gctacattct    1260

ggagacatag cttactggga cgaagacgaa cacttcttca tcgttgaccg cctgaagtct    1320

ctgattaagt acaaaggcta tcaggtggct cccgctgaat tggaatccat cttgctccaa    1380

caccccaaca tcttcgacgc aggtgtcgca ggtcttcccg acgatgacgc cggtgaactt    1440

cccgccgccg ttgttgtttt ggagcacgga aagacgatga cggaaaaaga gatcgtggat    1500

tacgtcgcca gtcaagtaac aaccgcgaaa aagttgcgcg gaggagttgt gtttgtggac    1560

gaagtaccga aaggtcttac cggaaaactc gacgcaagaa aaatcagaga gatcctcata    1620

aaggccaaga agggcggaaa gatcgccgtg taa                                 1653


<210> 2
<211> 550
<212> PRT
<213> Photinus pyralis


<400> 2
Val Thr Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      
Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          
Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              
Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  
Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  
Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      
Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         
Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             
Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 
Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 
Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     
Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         
Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             
Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 
Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 
Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     
Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         
Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             
Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 
Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 
Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     
Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         
Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             
Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 
Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 
Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     
Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         
Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             
Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 
Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 
Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     
Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         
Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             
Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 
Gly Gly Lys Ile Ala Val 
545                 550 

<210> 3
<211> 27
<212> DNA
<213> Artificial Sequence

<223> "Primer"

<220> 
<223> Primer

<400> 3
attgaattcg tcaccgacgc caaaaac                                        27


<210> 4
<211> 27
<212> DNA
<213> Artificial Sequence

<223> "Primer"

<220> 
<223> Primer

<400> 4
attggatcct tacacggcga tctttcc                                        27


<210> 5
<211> 1431
<212> DNA
<213> Homo sapiens


<400> 5
atgggcgcgg gggtgctcgt cctgggcgcc tccgagcccg gtaacctgtc gtcggccgca      60

ccgctccccg acggcgcggc caccgcggcg cggctgctgg tgcccgcgtc gccgcccgcc     120

tcgttgctgc ctcccgccag cgaaagcccc gagccgctgt ctcagcagtg gacagcgggc     180

atgggtctgc tgatggcgct catcgtgctg ctcatcgtgg cgggcaatgt gctggtgatc     240

gtggccatcg ccaagacgcc gcggctgcag acgctcacca acctcttcat catgtccctg     300

gccagcgccg acctggtcat ggggctgctg gtggtgccgt tcggggccac catcgtggtg     360

tggggccgct gggagtacgg ctccttcttc tgcgagctgt ggacctcagt ggacgtgctg     420

tgcgtgacgg ccagcatcga gaccctgtgt gtcattgccc tggaccgcta cctcgccatc     480

acctcgccct tccgctacca gagcctgctg acgcgcgcgc gggcgcgggg cctcgtgtgc     540

accgtgtggg ccatctcggc cctggtgtcc ttcctgccca tcctcatgca ctggtggcgg     600

gcggagagcg acgaggcgcg ccgctgctac aacgacccca agtgctgcga cttcgtcacc     660

aaccgggcct acgccatcgc ctcgtccgta gtctccttct acgtgcccct gtgcatcatg     720

gccttcgtgt acctgcgggt gttccgcgag gcccagaagc aggtgaagaa gatcgacagc     780

tgcgagcgcc gtttcctcgg cggcccagcg cggccgccct cgccctcgcc ctcgcccgtc     840

cccgcgcccg cgccgccgcc cggacccccg cgccccgccg ccgccgccgc caccgccccg     900

ctggccaacg ggcgtgcggg taagcggcgg ccctcgcgcc tcgtggccct gcgcgagcag     960

aaggcgctca agacgctggg catcatcatg ggcgtcttca cgctctgctg gctgcccttc    1020

ttcctggcca acgtggtgaa ggccttccac cgcgagctgg tgcccgaccg cctcttcgtc    1080

ttcttcaact ggctgggcta cgccaactcg gccttcaacc ccatcatcta ctgccgcagc    1140

cccgacttcc gcaaggcctt ccagggactg ctctgctgcg cgcgcagggc tgcccgccgg    1200

cgccacgcga cccacggaga ccggccgcgc gcctcgggct gtctggcccg gcccggaccc    1260

ccgccatcgc ccggggccgc ctcggacgac gacgacgacg atgtcgtcgg ggccacgccg    1320

cccgcgcgcc tgctggagcc ctgggccggc tgcaacggcg gggcggcggc ggacagcgac    1380

tcgagcctgg acgagccgtg ccgccccggc ttcgcctcgg aatccaaggt g             1431


<210> 6
<211> 496
<212> PRT
<213> Homo sapiens


<400> 6
Met Gly Ala Gly Val Leu Val Leu Gly Ala Ser Glu Pro Gly Asn Leu 
1               5                   10                  15      
Ser Ser Ala Ala Pro Leu Pro Asp Gly Ala Ala Thr Ala Ala Arg Leu 
            20                  25                  30          
Leu Val Pro Ala Ser Pro Pro Ala Ser Leu Leu Pro Pro Ala Ser Glu 
        35                  40                  45              
Ser Pro Glu Pro Leu Ser Gln Gln Trp Thr Ala Gly Met Gly Leu Leu 
    50                  55                  60                  
Met Ala Leu Ile Val Leu Leu Ile Val Ala Gly Asn Val Leu Val Ile 
65                  70                  75                  80  
Val Ala Ile Ala Lys Thr Pro Arg Leu Gln Thr Leu Thr Asn Leu Phe 
                85                  90                  95      
Ile Met Ser Leu Ala Ser Ala Asp Leu Val Met Gly Leu Leu Val Val 
            100                 105                 110         
Pro Phe Gly Ala Thr Ile Val Val Trp Gly Arg Trp Glu Tyr Gly Ser 
        115                 120                 125             
Phe Phe Cys Glu Leu Trp Thr Ser Val Asp Val Leu Cys Val Thr Ala 
    130                 135                 140                 
Ser Ile Glu Thr Leu Cys Val Ile Ala Leu Asp Arg Tyr Leu Ala Ile 
145                 150                 155                 160 
Thr Ser Pro Phe Arg Tyr Gln Ser Leu Leu Thr Arg Ala Arg Ala Arg 
                165                 170                 175     
Gly Leu Val Cys Thr Val Trp Ala Ile Ser Ala Leu Val Ser Phe Leu 
            180                 185                 190         
Pro Ile Leu Met His Trp Trp Arg Ala Glu Ser Asp Glu Ala Arg Arg 
        195                 200                 205             
Cys Tyr Asn Asp Pro Lys Cys Cys Asp Phe Val Thr Asn Arg Ala Tyr 
    210                 215                 220                 
Ala Ile Ala Ser Ser Val Val Ser Phe Tyr Val Pro Leu Cys Ile Met 
225                 230                 235                 240 
Ala Phe Val Tyr Leu Arg Val Phe Arg Glu Ala Gln Lys Gln Val Lys 
                245                 250                 255     
Lys Ile Asp Ser Cys Glu Arg Arg Phe Leu Gly Gly Pro Ala Arg Pro 
            260                 265                 270         
Pro Ser Pro Ser Pro Ser Pro Val Pro Ala Pro Ala Pro Pro Pro Gly 
        275                 280                 285             
Pro Pro Arg Pro Ala Ala Ala Ala Ala Thr Ala Pro Leu Ala Asn Gly 
    290                 295                 300                 
Arg Ala Gly Lys Arg Arg Pro Ser Arg Leu Val Ala Leu Arg Glu Gln 
305                 310                 315                 320 
Lys Ala Leu Lys Thr Leu Gly Ile Ile Met Gly Val Phe Thr Leu Cys 
                325                 330                 335     
Trp Leu Pro Phe Phe Leu Ala Asn Val Val Lys Ala Phe His Arg Glu 
            340                 345                 350         
Leu Val Pro Asp Arg Leu Phe Val Phe Phe Asn Trp Leu Gly Tyr Ala 
        355                 360                 365             
Asn Ser Ala Phe Asn Pro Ile Ile Tyr Cys Arg Ser Pro Asp Phe Arg 
    370                 375                 380                 
Lys Ala Phe Gln Gly Leu Leu Cys Cys Ala Arg Arg Ala Ala Arg Arg 
385                 390                 395                 400 
Arg His Ala Thr His Gly Asp Arg Pro Arg Ala Ser Gly Cys Leu Ala 
                405                 410                 415     
Arg Pro Gly Pro Pro Pro Ser Pro Gly Ala Ala Ser Asp Asp Asp Asp 
            420                 425                 430         
Asp Asp Val Val Gly Ala Thr Pro Pro Ala Arg Leu Leu Glu Pro Trp 
        435                 440                 445             
Ala Gly Cys Asn Gly Gly Ala Ala Ala Asp Ser Asp Ser Ser Leu Asp 
    450                 455                 460                 
Glu Pro Cys Arg Pro Gly Phe Ala Ser Glu Ser Lys Val Phe Ala Ser 
465                 470                 475                 480 
Glu Ser Lys Val Gly Gln His Arg Gln Gly His Pro Glu Asn Arg Asp 
                485                 490                 495     



<210> 7
<211> 30
<212> DNA
<213> Artificial Sequence

<223> "Primer"

<220> 
<223> Primer

<400> 7
atagatatca tgggcgcggg ggtgctcgtc                                     30


<210> 8
<211> 30
<212> DNA
<213> Artificial Sequence

<223> "Primer"

<220> 
<223> Primer

<400> 8
atagaattcc accttggatt ccgaggcgaa                                     30


<210> 9
<211> 3084
<212> DNA
<213> Homo sapiens


<400> 9
atgggcgcgg gggtgctcgt cctgggcgcc tccgagcccg gtaacctgtc gtcggccgca      60

ccgctccccg acggcgcggc caccgcggcg cggctgctgg tgcccgcgtc gccgcccgcc     120

tcgttgctgc ctcccgccag cgaaagcccc gagccgctgt ctcagcagtg gacagcgggc     180

atgggtctgc tgatggcgct catcgtgctg ctcatcgtgg cgggcaatgt gctggtgatc     240

gtggccatcg ccaagacgcc gcggctgcag acgctcacca acctcttcat catgtccctg     300

gccagcgccg acctggtcat ggggctgctg gtggtgccgt tcggggccac catcgtggtg     360

tggggccgct gggagtacgg ctccttcttc tgcgagctgt ggacctcagt ggacgtgctg     420

tgcgtgacgg ccagcatcga gaccctgtgt gtcattgccc tggaccgcta cctcgccatc     480

acctcgccct tccgctacca gagcctgctg acgcgcgcgc gggcgcgggg cctcgtgtgc     540

accgtgtggg ccatctcggc cctggtgtcc ttcctgccca tcctcatgca ctggtggcgg     600

gcggagagcg acgaggcgcg ccgctgctac aacgacccca agtgctgcga cttcgtcacc     660

aaccgggcct acgccatcgc ctcgtccgta gtctccttct acgtgcccct gtgcatcatg     720

gccttcgtgt acctgcgggt gttccgcgag gcccagaagc aggtgaagaa gatcgacagc     780

tgcgagcgcc gtttcctcgg cggcccagcg cggccgccct cgccctcgcc ctcgcccgtc     840

cccgcgcccg cgccgccgcc cggacccccg cgccccgccg ccgccgccgc caccgccccg     900

ctggccaacg ggcgtgcggg taagcggcgg ccctcgcgcc tcgtggccct gcgcgagcag     960

aaggcgctca agacgctggg catcatcatg ggcgtcttca cgctctgctg gctgcccttc    1020

ttcctggcca acgtggtgaa ggccttccac cgcgagctgg tgcccgaccg cctcttcgtc    1080

ttcttcaact ggctgggcta cgccaactcg gccttcaacc ccatcatcta ctgccgcagc    1140

cccgacttcc gcaaggcctt ccagggactg ctctgctgcg cgcgcagggc tgcccgccgg    1200

cgccacgcga cccacggaga ccggccgcgc gcctcgggct gtctggcccg gcccggaccc    1260

ccgccatcgc ccggggccgc ctcggacgac gacgacgacg atgtcgtcgg ggccacgccg    1320

cccgcgcgcc tgctggagcc ctgggccggc tgcaacggcg gggcggcggc ggacagcgac    1380

tcgagcctgg acgagccgtg ccgccccggc ttcgcctcgg aatccaaggt ggtcaccgac    1440

gccaaaaaca taaagaaagg cccggcgcca ttctatccgc tggaagatgg aaccgctgga    1500

gagcaactgc ataaggctat gaagagatac gccctggttc ctggaacaat tgcttttaca    1560

gatgcacata tcgaggtgga catcacttac gctgagtact tcgaaatgtc cgttcggttg    1620

gcagaagcta tgaaacgata tgggctgaat acaaatcaca gaatcgtcgt atgcagtgaa    1680

aactctcttc aattctttat gccggtgttg ggcgcgttat ttatcggagt tgcagttgcg    1740

cccgcgaacg acatttataa tgaacgtgaa ttgctcaaca gtatgggcat ttcgcagcct    1800

accgtggtgt tcgtttccaa aaaggggttg caaaaaattt tgaacgtgca aaaaaagctc    1860

ccaatcatcc aaaaaattat tatcatggat tctaaaacgg attaccaggg atttcagtcg    1920

atgtacacgt tcgtcacatc tcatctacct cccggtttta atgaatacga ttttgtgcca    1980

gagtccttcg atagggacaa gacaattgca ctgatcatga actcctctgg atctactggt    2040

ctgcctaaag gtgtcgctct gcctcataga actgcctgcg tgagattctc gcatgccaga    2100

gatcctattt ttggcaatca aatcattccg gatactgcga ttttaagtgt tgttccattc    2160

catcacggtt ttggaatgtt tactacactc ggatatttga tatgtggatt tcgagtcgtc    2220

ttaatgtata gatttgaaga agagctgttt ctgaggagcc ttcaggatta caagattcaa    2280

agtgcgctgc tggtgccaac cctattctcc ttcttcgcca aaagcactct gattgacaaa    2340

tacgatttat ctaatttaca cgaaattgct tctggtggcg ctcccctctc taaggaagtc    2400

ggggaagcgg ttgccaagag gttccatctg ccaggtatca ggcaaggata tgggctcact    2460

gagactacat cagctattct gattacaccc gagggggatg ataaaccggg cgcggtcggt    2520

aaagttgttc cattttttga agcgaaggtt gtggatctgg ataccgggaa aacgctgggc    2580

gttaatcaaa gaggcgaact gtgtgtgaga ggtcctatga ttatgtccgg ttatgtaaac    2640

aatccggaag cgaccaacgc cttgattgac aaggatggat ggctacattc tggagacata    2700

gcttactggg acgaagacga acacttcttc atcgttgacc gcctgaagtc tctgattaag    2760

tacaaaggct atcaggtggc tcccgctgaa ttggaatcca tcttgctcca acaccccaac    2820

atcttcgacg caggtgtcgc aggtcttccc gacgatgacg ccggtgaact tcccgccgcc    2880

gttgttgttt tggagcacgg aaagacgatg acggaaaaag agatcgtgga ttacgtcgcc    2940

agtcaagtaa caaccgcgaa aaagttgcgc ggaggagttg tgtttgtgga cgaagtaccg    3000

aaaggtctta ccggaaaact cgacgcaaga aaaatcagag agatcctcat aaaggccaag    3060

aagggcggaa agatcgccgt gtaa                                           3084


<210> 10
<211> 1027
<212> PRT
<213> Homo sapiens


<400> 10
Met Gly Ala Gly Val Leu Val Leu Gly Ala Ser Glu Pro Gly Asn Leu 
1               5                   10                  15      
Ser Ser Ala Ala Pro Leu Pro Asp Gly Ala Ala Thr Ala Ala Arg Leu 
            20                  25                  30          
Leu Val Pro Ala Ser Pro Pro Ala Ser Leu Leu Pro Pro Ala Ser Glu 
        35                  40                  45              
Ser Pro Glu Pro Leu Ser Gln Gln Trp Thr Ala Gly Met Gly Leu Leu 
    50                  55                  60                  
Met Ala Leu Ile Val Leu Leu Ile Val Ala Gly Asn Val Leu Val Ile 
65                  70                  75                  80  
Val Ala Ile Ala Lys Thr Pro Arg Leu Gln Thr Leu Thr Asn Leu Phe 
                85                  90                  95      
Ile Met Ser Leu Ala Ser Ala Asp Leu Val Met Gly Leu Leu Val Val 
            100                 105                 110         
Pro Phe Gly Ala Thr Ile Val Val Trp Gly Arg Trp Glu Tyr Gly Ser 
        115                 120                 125             
Phe Phe Cys Glu Leu Trp Thr Ser Val Asp Val Leu Cys Val Thr Ala 
    130                 135                 140                 
Ser Ile Glu Thr Leu Cys Val Ile Ala Leu Asp Arg Tyr Leu Ala Ile 
145                 150                 155                 160 
Thr Ser Pro Phe Arg Tyr Gln Ser Leu Leu Thr Arg Ala Arg Ala Arg 
                165                 170                 175     
Gly Leu Val Cys Thr Val Trp Ala Ile Ser Ala Leu Val Ser Phe Leu 
            180                 185                 190         
Pro Ile Leu Met His Trp Trp Arg Ala Glu Ser Asp Glu Ala Arg Arg 
        195                 200                 205             
Cys Tyr Asn Asp Pro Lys Cys Cys Asp Phe Val Thr Asn Arg Ala Tyr 
    210                 215                 220                 
Ala Ile Ala Ser Ser Val Val Ser Phe Tyr Val Pro Leu Cys Ile Met 
225                 230                 235                 240 
Ala Phe Val Tyr Leu Arg Val Phe Arg Glu Ala Gln Lys Gln Val Lys 
                245                 250                 255     
Lys Ile Asp Ser Cys Glu Arg Arg Phe Leu Gly Gly Pro Ala Arg Pro 
            260                 265                 270         
Pro Ser Pro Ser Pro Ser Pro Val Pro Ala Pro Ala Pro Pro Pro Gly 
        275                 280                 285             
Pro Pro Arg Pro Ala Ala Ala Ala Ala Thr Ala Pro Leu Ala Asn Gly 
    290                 295                 300                 
Arg Ala Gly Lys Arg Arg Pro Ser Arg Leu Val Ala Leu Arg Glu Gln 
305                 310                 315                 320 
Lys Ala Leu Lys Thr Leu Gly Ile Ile Met Gly Val Phe Thr Leu Cys 
                325                 330                 335     
Trp Leu Pro Phe Phe Leu Ala Asn Val Val Lys Ala Phe His Arg Glu 
            340                 345                 350         
Leu Val Pro Asp Arg Leu Phe Val Phe Phe Asn Trp Leu Gly Tyr Ala 
        355                 360                 365             
Asn Ser Ala Phe Asn Pro Ile Ile Tyr Cys Arg Ser Pro Asp Phe Arg 
    370                 375                 380                 
Lys Ala Phe Gln Gly Leu Leu Cys Cys Ala Arg Arg Ala Ala Arg Arg 
385                 390                 395                 400 
Arg His Ala Thr His Gly Asp Arg Pro Arg Ala Ser Gly Cys Leu Ala 
                405                 410                 415     
Arg Pro Gly Pro Pro Pro Ser Pro Gly Ala Ala Ser Asp Asp Asp Asp 
            420                 425                 430         
Asp Asp Val Val Gly Ala Thr Pro Pro Ala Arg Leu Leu Glu Pro Trp 
        435                 440                 445             
Ala Gly Cys Asn Gly Gly Ala Ala Ala Asp Ser Asp Ser Ser Leu Asp 
    450                 455                 460                 
Glu Pro Cys Arg Pro Gly Phe Ala Ser Glu Ser Lys Val Val Thr Asp 
465                 470                 475                 480 
Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro Leu Glu Asp 
                485                 490                 495     
Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg Tyr Ala Leu 
            500                 505                 510         
Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu Val Asp Ile 
        515                 520                 525             
Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala Glu Ala Met 
    530                 535                 540                 
Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val Cys Ser Glu 
545                 550                 555                 560 
Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu Phe Ile Gly 
                565                 570                 575     
Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg Glu Leu Leu 
            580                 585                 590         
Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val Ser Lys Lys 
        595                 600                 605             
Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro Ile Ile Gln 
    610                 615                 620                 
Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly Phe Gln Ser 
625                 630                 635                 640 
Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe Asn Glu Tyr 
                645                 650                 655     
Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile Ala Leu Ile 
            660                 665                 670         
Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val Ala Leu Pro 
        675                 680                 685             
His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp Pro Ile Phe 
    690                 695                 700                 
Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val Val Pro Phe 
705                 710                 715                 720 
His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu Ile Cys Gly 
                725                 730                 735     
Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu Phe Leu Arg 
            740                 745                 750         
Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val Pro Thr Leu 
        755                 760                 765             
Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr Asp Leu Ser 
    770                 775                 780                 
Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser Lys Glu Val 
785                 790                 795                 800 
Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile Arg Gln Gly 
                805                 810                 815     
Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr Pro Glu Gly 
            820                 825                 830         
Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe Phe Glu Ala 
        835                 840                 845             
Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val Asn Gln Arg 
    850                 855                 860                 
Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly Tyr Val Asn 
865                 870                 875                 880 
Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly Trp Leu His 
                885                 890                 895     
Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe Phe Ile Val 
            900                 905                 910         
Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln Val Ala Pro 
        915                 920                 925             
Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile Phe Asp Ala 
    930                 935                 940                 
Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu Pro Ala Ala 
945                 950                 955                 960 
Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys Glu Ile Val 
                965                 970                 975     
Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu Arg Gly Gly 
            980                 985                 990         
Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly Lys Leu Asp 
        995                 1000                1005            
Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys Gly Gly Lys 
    1010                1015                1020                
Ile Ala Val 
1025        

<210> 11
<211> 1239
<212> DNA
<213> Homo sapiens


<400> 11
atggggcaac ccgggaacgg cagcgccttc ttgctggcac ccaatagaag ccatgcgccg      60

gaccacgacg tcacgcagca aagggacgag gtgtgggtgg tgggcatggg catcgtcatg     120

tctctcatcg tcctggccat cgtgtttggc aatgtgctgg tcatcacagc cattgccaag     180

ttcgagcgtc tgcagacggt caccaactac ttcatcactt cactggcctg tgctgatctg     240

gtcatgggcc tggcagtggt gccctttggg gccgcccata ttcttatgaa aatgtggact     300

tttggcaact tctggtgcga gttttggact tccattgatg tgctgtgcgt cacggccagc     360

attgagaccc tgtgcgtgat cgcagtggat cgctactttg ccattacttc acctttcaag     420

taccagagcc tgctgaccaa gaataaggcc cgggtgatca ttctgatggt gtggattgtg     480

tcaggcctta cctccttctt gcccattcag atgcactggt accgggccac ccaccaggaa     540

gccatcaact gctatgccaa tgagacctgc tgtgacttct tcacgaacca agcctatgcc     600

attgcctctt ccatcgtgtc cttctacgtt cccctggtga tcatggtctt cgtctactcc     660

agggtctttc aggaggccaa aaggcagctc cagaagattg acaaatctga gggccgcttc     720

catgtccaga accttagcca ggtggagcag gatgggcgga cggggcatgg actccgcaga     780

tcttccaagt tctgcttgaa ggagcacaaa gccctcaaga cgttaggcat catcatgggc     840

actttcaccc tctgctggct gcccttcttc atcgttaaca ttgtgcatgt gatccaggat     900

aacctcatcc gtaaggaagt ttacatcctc ctaaattgga taggctatgt caattctggt     960

ttcaatcccc ttatctactg ccggagccca gatttcagga ttgccttcca ggagcttctg    1020

tgcctgcgca ggtcttcttt gaaggcctat gggaatggct actccagcaa cggcaacaca    1080

ggggagcaga gtggatatca cgtggaacag gagaaagaaa ataaactgct gtgtgaagac    1140

ctcccaggca cggaagactt tgtgggccat caaggtactg tgcctagcga taacattgat    1200

tcacaaggga ggaattgtag tacaaatgac tcactgctg                           1239


<210> 12
<211> 413
<212> PRT
<213> Homo sapiens


<400> 12
Met Gly Gln Pro Gly Asn Gly Ser Ala Phe Leu Leu Ala Pro Asn Gly 
1               5                   10                  15      
Ser His Ala Pro Asp His Asp Val Thr Gln Glu Arg Asp Glu Val Trp 
            20                  25                  30          
Val Val Gly Met Gly Ile Val Met Ser Leu Ile Val Leu Ala Ile Val 
        35                  40                  45              
Phe Gly Asn Val Leu Val Ile Thr Ala Ile Ala Lys Phe Glu Arg Leu 
    50                  55                  60                  
Gln Thr Val Thr Asn Tyr Phe Ile Thr Ser Leu Ala Cys Ala Asp Leu 
65                  70                  75                  80  
Val Met Gly Leu Ala Val Val Pro Phe Gly Ala Ala His Ile Leu Met 
                85                  90                  95      
Lys Met Trp Thr Phe Gly Asn Phe Trp Cys Glu Phe Trp Thr Ser Ile 
            100                 105                 110         
Asp Val Leu Cys Val Thr Ala Ser Ile Glu Thr Leu Cys Val Ile Ala 
        115                 120                 125             
Val Asp Arg Tyr Phe Ala Ile Thr Ser Pro Phe Lys Tyr Gln Ser Leu 
    130                 135                 140                 
Leu Thr Lys Asn Lys Ala Arg Val Ile Ile Leu Met Val Trp Ile Val 
145                 150                 155                 160 
Ser Gly Leu Thr Ser Phe Leu Pro Ile Gln Met His Trp Tyr Arg Ala 
                165                 170                 175     
Thr His Gln Glu Ala Ile Asn Cys Tyr Ala Asn Glu Thr Cys Cys Asp 
            180                 185                 190         
Phe Phe Thr Asn Gln Ala Tyr Ala Ile Ala Ser Ser Ile Val Ser Phe 
        195                 200                 205             
Tyr Val Pro Leu Val Ile Met Val Phe Val Tyr Ser Arg Val Phe Gln 
    210                 215                 220                 
Glu Ala Lys Arg Gln Leu Gln Lys Ile Asp Lys Ser Glu Gly Arg Phe 
225                 230                 235                 240 
His Val Gln Asn Leu Ser Gln Val Glu Gln Asp Gly Arg Thr Gly His 
                245                 250                 255     
Gly Leu Arg Arg Ser Ser Lys Phe Cys Leu Lys Glu His Lys Ala Leu 
            260                 265                 270         
Lys Thr Leu Gly Ile Ile Met Gly Thr Phe Thr Leu Cys Trp Leu Pro 
        275                 280                 285             
Phe Phe Ile Val Asn Ile Val His Val Ile Gln Asp Asn Leu Ile Arg 
    290                 295                 300                 
Lys Glu Val Tyr Ile Leu Leu Asn Trp Ile Gly Tyr Val Asn Ser Gly 
305                 310                 315                 320 
Phe Asn Pro Leu Ile Tyr Cys Arg Ser Pro Asp Phe Arg Ile Ala Phe 
                325                 330                 335     
Gln Glu Leu Leu Cys Leu Arg Arg Ser Ser Leu Lys Ala Tyr Gly Asn 
            340                 345                 350         
Gly Tyr Ser Ser Asn Gly Asn Thr Gly Glu Gln Ser Gly Tyr His Val 
        355                 360                 365             
Glu Gln Glu Lys Glu Asn Lys Leu Leu Cys Glu Asp Leu Pro Gly Thr 
    370                 375                 380                 
Glu Asp Phe Val Gly His Gln Gly Thr Val Pro Ser Asp Asn Ile Asp 
385                 390                 395                 400 
Ser Gln Gly Arg Asn Cys Ser Thr Asn Asp Ser Leu Leu 
                405                 410             

<210> 13
<211> 32
<212> DNA
<213> Artificial Sequence

<223> "Primer"

<220> 
<223> Primer

<400> 13
atagcggccg catggggcaa cccgggaacg gc                                   32


<210> 14
<211> 33
<212> DNA
<213> Artificial Sequence

<223> "Primer"

<220> 
<223> Primer

<400> 14
atagaattcc agcagtgagt catttgtact aca                                  33


<210> 15
<211> 2892
<212> DNA
<213> Homo sapiens


<400> 15
atggggcaac ccgggaacgg cagcgccttc ttgctggcac ccaatagaag ccatgcgccg      60

gaccacgacg tcacgcagca aagggacgag gtgtgggtgg tgggcatggg catcgtcatg     120

tctctcatcg tcctggccat cgtgtttggc aatgtgctgg tcatcacagc cattgccaag     180

ttcgagcgtc tgcagacggt caccaactac ttcatcactt cactggcctg tgctgatctg     240

gtcatgggcc tggcagtggt gccctttggg gccgcccata ttcttatgaa aatgtggact     300

tttggcaact tctggtgcga gttttggact tccattgatg tgctgtgcgt cacggccagc     360

attgagaccc tgtgcgtgat cgcagtggat cgctactttg ccattacttc acctttcaag     420

taccagagcc tgctgaccaa gaataaggcc cgggtgatca ttctgatggt gtggattgtg     480

tcaggcctta cctccttctt gcccattcag atgcactggt accgggccac ccaccaggaa     540

gccatcaact gctatgccaa tgagacctgc tgtgacttct tcacgaacca agcctatgcc     600

attgcctctt ccatcgtgtc cttctacgtt cccctggtga tcatggtctt cgtctactcc     660

agggtctttc aggaggccaa aaggcagctc cagaagattg acaaatctga gggccgcttc     720

catgtccaga accttagcca ggtggagcag gatgggcgga cggggcatgg actccgcaga     780

tcttccaagt tctgcttgaa ggagcacaaa gccctcaaga cgttaggcat catcatgggc     840

actttcaccc tctgctggct gcccttcttc atcgttaaca ttgtgcatgt gatccaggat     900

aacctcatcc gtaaggaagt ttacatcctc ctaaattgga taggctatgt caattctggt     960

ttcaatcccc ttatctactg ccggagccca gatttcagga ttgccttcca ggagcttctg    1020

tgcctgcgca ggtcttcttt gaaggcctat gggaatggct actccagcaa cggcaacaca    1080

ggggagcaga gtggatatca cgtggaacag gagaaagaaa ataaactgct gtgtgaagac    1140

ctcccaggca cggaagactt tgtgggccat caaggtactg tgcctagcga taacattgat    1200

tcacaaggga ggaattgtag tacaaatgac tcactgctgg tcaccgacgc caaaaacata    1260

aagaaaggcc cggcgccatt ctatccgctg gaagatggaa ccgctggaga gcaactgcat    1320

aaggctatga agagatacgc cctggttcct ggaacaattg cttttacaga tgcacatatc    1380

gaggtggaca tcacttacgc tgagtacttc gaaatgtccg ttcggttggc agaagctatg    1440

aaacgatatg ggctgaatac aaatcacaga atcgtcgtat gcagtgaaaa ctctcttcaa    1500

ttctttatgc cggtgttggg cgcgttattt atcggagttg cagttgcgcc cgcgaacgac    1560

atttataatg aacgtgaatt gctcaacagt atgggcattt cgcagcctac cgtggtgttc    1620

gtttccaaaa aggggttgca aaaaattttg aacgtgcaaa aaaagctccc aatcatccaa    1680

aaaattatta tcatggattc taaaacggat taccagggat ttcagtcgat gtacacgttc    1740

gtcacatctc atctacctcc cggttttaat gaatacgatt ttgtgccaga gtccttcgat    1800

agggacaaga caattgcact gatcatgaac tcctctggat ctactggtct gcctaaaggt    1860

gtcgctctgc ctcatagaac tgcctgcgtg agattctcgc atgccagaga tcctattttt    1920

ggcaatcaaa tcattccgga tactgcgatt ttaagtgttg ttccattcca tcacggtttt    1980

ggaatgttta ctacactcgg atatttgata tgtggatttc gagtcgtctt aatgtataga    2040

tttgaagaag agctgtttct gaggagcctt caggattaca agattcaaag tgcgctgctg    2100

gtgccaaccc tattctcctt cttcgccaaa agcactctga ttgacaaata cgatttatct    2160

aatttacacg aaattgcttc tggtggcgct cccctctcta aggaagtcgg ggaagcggtt    2220

gccaagaggt tccatctgcc aggtatcagg caaggatatg ggctcactga gactacatca    2280

gctattctga ttacacccga gggggatgat aaaccgggcg cggtcggtaa agttgttcca    2340

ttttttgaag cgaaggttgt ggatctggat accgggaaaa cgctgggcgt taatcaaaga    2400

ggcgaactgt gtgtgagagg tcctatgatt atgtccggtt atgtaaacaa tccggaagcg    2460

accaacgcct tgattgacaa ggatggatgg ctacattctg gagacatagc ttactgggac    2520

gaagacgaac acttcttcat cgttgaccgc ctgaagtctc tgattaagta caaaggctat    2580

caggtggctc ccgctgaatt ggaatccatc ttgctccaac accccaacat cttcgacgca    2640

ggtgtcgcag gtcttcccga cgatgacgcc ggtgaacttc ccgccgccgt tgttgttttg    2700

gagcacggaa agacgatgac ggaaaaagag atcgtggatt acgtcgccag tcaagtaaca    2760

accgcgaaaa agttgcgcgg aggagttgtg tttgtggacg aagtaccgaa aggtcttacc    2820

ggaaaactcg acgcaagaaa aatcagagag atcctcataa aggccaagaa gggcggaaag    2880

atcgccgtgt aa                                                        2892


<210> 16
<211> 963
<212> PRT
<213> Homo sapiens


<400> 16
Met Gly Gln Pro Gly Asn Gly Ser Ala Phe Leu Leu Ala Pro Asn Arg 
1               5                   10                  15      
Ser His Ala Pro Asp His Asp Val Thr Gln Gln Arg Asp Glu Val Trp 
            20                  25                  30          
Val Val Gly Met Gly Ile Val Met Ser Leu Ile Val Leu Ala Ile Val 
        35                  40                  45              
Phe Gly Asn Val Leu Val Ile Thr Ala Ile Ala Lys Phe Glu Arg Leu 
    50                  55                  60                  
Gln Thr Val Thr Asn Tyr Phe Ile Thr Ser Leu Ala Cys Ala Asp Leu 
65                  70                  75                  80  
Val Met Gly Leu Ala Val Val Pro Phe Gly Ala Ala His Ile Leu Met 
                85                  90                  95      
Lys Met Trp Thr Phe Gly Asn Phe Trp Cys Glu Phe Trp Thr Ser Ile 
            100                 105                 110         
Asp Val Leu Cys Val Thr Ala Ser Ile Glu Thr Leu Cys Val Ile Ala 
        115                 120                 125             
Val Asp Arg Tyr Phe Ala Ile Thr Ser Pro Phe Lys Tyr Gln Ser Leu 
    130                 135                 140                 
Leu Thr Lys Asn Lys Ala Arg Val Ile Ile Leu Met Val Trp Ile Val 
145                 150                 155                 160 
Ser Gly Leu Thr Ser Phe Leu Pro Ile Gln Met His Trp Tyr Arg Ala 
                165                 170                 175     
Thr His Gln Glu Ala Ile Asn Cys Tyr Ala Asn Glu Thr Cys Cys Asp 
            180                 185                 190         
Phe Phe Thr Asn Gln Ala Tyr Ala Ile Ala Ser Ser Ile Val Ser Phe 
        195                 200                 205             
Tyr Val Pro Leu Val Ile Met Val Phe Val Tyr Ser Arg Val Phe Gln 
    210                 215                 220                 
Glu Ala Lys Arg Gln Leu Gln Lys Ile Asp Lys Ser Glu Gly Arg Phe 
225                 230                 235                 240 
His Val Gln Asn Leu Ser Gln Val Glu Gln Asp Gly Arg Thr Gly His 
                245                 250                 255     
Gly Leu Arg Arg Ser Ser Lys Phe Cys Leu Lys Glu His Lys Ala Leu 
            260                 265                 270         
Lys Thr Leu Gly Ile Ile Met Gly Thr Phe Thr Leu Cys Trp Leu Pro 
        275                 280                 285             
Phe Phe Ile Val Asn Ile Val His Val Ile Gln Asp Asn Leu Ile Arg 
    290                 295                 300                 
Lys Glu Val Tyr Ile Leu Leu Asn Trp Ile Gly Tyr Val Asn Ser Gly 
305                 310                 315                 320 
Phe Asn Pro Leu Ile Tyr Cys Arg Ser Pro Asp Phe Arg Ile Ala Phe 
                325                 330                 335     
Gln Glu Leu Leu Cys Leu Arg Arg Ser Ser Leu Lys Ala Tyr Gly Asn 
            340                 345                 350         
Gly Tyr Ser Ser Asn Gly Asn Thr Gly Glu Gln Ser Gly Tyr His Val 
        355                 360                 365             
Glu Gln Glu Lys Glu Asn Lys Leu Leu Cys Glu Asp Leu Pro Gly Thr 
    370                 375                 380                 
Glu Asp Phe Val Gly His Gln Gly Thr Val Pro Ser Asp Asn Ile Asp 
385                 390                 395                 400 
Ser Gln Gly Arg Asn Cys Ser Thr Asn Asp Ser Leu Leu Val Thr Asp 
                405                 410                 415     
Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro Leu Glu Asp 
            420                 425                 430         
Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg Tyr Ala Leu 
        435                 440                 445             
Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu Val Asp Ile 
    450                 455                 460                 
Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala Glu Ala Met 
465                 470                 475                 480 
Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val Cys Ser Glu 
                485                 490                 495     
Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu Phe Ile Gly 
            500                 505                 510         
Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg Glu Leu Leu 
        515                 520                 525             
Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val Ser Lys Lys 
    530                 535                 540                 
Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro Ile Ile Gln 
545                 550                 555                 560 
Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly Phe Gln Ser 
                565                 570                 575     
Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe Asn Glu Tyr 
            580                 585                 590         
Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile Ala Leu Ile 
        595                 600                 605             
Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val Ala Leu Pro 
    610                 615                 620                 
His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp Pro Ile Phe 
625                 630                 635                 640 
Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val Val Pro Phe 
                645                 650                 655     
His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu Ile Cys Gly 
            660                 665                 670         
Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu Phe Leu Arg 
        675                 680                 685             
Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val Pro Thr Leu 
    690                 695                 700                 
Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr Asp Leu Ser 
705                 710                 715                 720 
Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser Lys Glu Val 
                725                 730                 735     
Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile Arg Gln Gly 
            740                 745                 750         
Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr Pro Glu Gly 
        755                 760                 765             
Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe Phe Glu Ala 
    770                 775                 780                 
Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val Asn Gln Arg 
785                 790                 795                 800 
Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly Tyr Val Asn 
                805                 810                 815     
Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly Trp Leu His 
            820                 825                 830         
Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe Phe Ile Val 
        835                 840                 845             
Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln Val Ala Pro 
    850                 855                 860                 
Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile Phe Asp Ala 
865                 870                 875                 880 
Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu Pro Ala Ala 
                885                 890                 895     
Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys Glu Ile Val 
            900                 905                 910         
Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu Arg Gly Gly 
        915                 920                 925             
Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly Lys Leu Asp 
    930                 935                 940                 
Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys Gly Gly Lys 
945                 950                 955                 960 
Ile Ala Val 
            

<210> 17
<211> 1398
<212> DNA
<213> Homo sapiens


<400> 17
atgaataact caacaaactc ctctaacaat agcctggctc ttacaagtcc ttataagaca      60

tttgaagtgg tgtttattgt cctggtggct ggatccctca gtttggtgac cattatcggg     120

aacatcctag tcatggtttc cattaaagtc aaccgccacc tccagaccgt caacaattac     180

tttttattca gcttggcctg tgctgacctt atcataggtg ttttctccat gaacttgtac     240

accctctaca ctgtgattgg ttactggcct ttgggacctg tggtgtgtga cctttggcta     300

gccctggact atgtggtcag caatgcctca gttatgaatc tgctcatcat cagctttgac     360

aggtacttct gtgtcacaaa acctctgacc tacccagtca agcggaccac aaaaatggca     420

ggtatgatga ttgcagctgc ctgggtcctc tctttcatcc tctgggctcc agccattctc     480

ttctggcagt tcattgtagg ggtgagaact gtggaggatg gggagtgcta cattcagttt     540

ttttccaatg ctgctgtcac ctttggtacg gctattgcag ccttctattt gccagtgatc     600

atcatgactg tgctatattg gcacatatcc cgagccagca agagcaggat aaagaaggac     660

aagaaggagc ctgttgccaa ccaagacccc gtttctccaa gtctggtaca aggaaggata     720

gtgaagccaa acaataacaa catgcccagc agtgacgatg gcctggagca caacaaaatc     780

cagaatggca aagcccccag ggatcctgtg actgaaaact gtgttcaggg agaggagaag     840

gagagctcca atgactccac ctcagtcagt gctgttgcct ctaatatgag agatgatgaa     900

ataacccagg atgaaaacac agtttccact tccctgggcc attccaaaga tgagaactct     960

aagcaaacat gcatcagaat tggcaccaag accccaaaaa gtgactcatg taccccaact    1020

aataccaccg tggaggtagt ggggtcttca ggtcagaatg gagatgaaaa gcagaatatt    1080

gtagcccgca agattgtgaa gatgactaag cagcctgcaa aaaagaagcc tcctccttcc    1140

cgggaaaaga aagtcaccag gacaatcttg gctattctgt tggctttcat catcacttgg    1200

gccccataca atgtcatggt gctcattaac accttttgtg caccttgcat ccccaacact    1260

gtgtggacaa ttggttactg gctttgttac atcaacagca ctatcaaccc tgcctgctat    1320

gcactttgca atgccacctt caagaagacc tttaaacacc ttctcatgtg tcattataag    1380

aacataggcg ctacaagg                                                  1398


<210> 18
<211> 466
<212> PRT
<213> Homo sapiens


<400> 18
Met Asn Asn Ser Thr Asn Ser Ser Asn Asn Ser Leu Ala Leu Thr Ser 
1               5                   10                  15      
Pro Tyr Lys Thr Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser 
            20                  25                  30          
Leu Ser Leu Val Thr Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile 
        35                  40                  45              
Lys Val Asn Arg His Leu Gln Thr Val Asn Asn Tyr Phe Leu Phe Ser 
    50                  55                  60                  
Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr 
65                  70                  75                  80  
Thr Leu Tyr Thr Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys 
                85                  90                  95      
Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met 
            100                 105                 110         
Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Thr Lys Pro 
        115                 120                 125             
Leu Thr Tyr Pro Val Lys Arg Thr Thr Lys Met Ala Gly Met Met Ile 
    130                 135                 140                 
Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu 
145                 150                 155                 160 
Phe Trp Gln Phe Ile Val Gly Val Arg Thr Val Glu Asp Gly Glu Cys 
                165                 170                 175     
Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Thr Phe Gly Thr Ala Ile 
            180                 185                 190         
Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Thr Val Leu Tyr Trp His 
        195                 200                 205             
Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Asp Lys Lys Glu Pro 
    210                 215                 220                 
Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile 
225                 230                 235                 240 
Val Lys Pro Asn Asn Asn Asn Met Pro Ser Ser Asp Asp Gly Leu Glu 
                245                 250                 255     
His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Pro Val Thr Glu 
            260                 265                 270         
Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Thr Ser 
        275                 280                 285             
Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Thr Gln Asp 
    290                 295                 300                 
Glu Asn Thr Val Ser Thr Ser Leu Gly His Ser Lys Asp Glu Asn Ser 
305                 310                 315                 320 
Lys Gln Thr Cys Ile Arg Ile Gly Thr Lys Thr Pro Lys Ser Asp Ser 
                325                 330                 335     
Cys Thr Pro Thr Asn Thr Thr Val Glu Val Val Gly Ser Ser Gly Gln 
            340                 345                 350         
Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met 
        355                 360                 365             
Thr Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys 
    370                 375                 380                 
Val Thr Arg Thr Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp 
385                 390                 395                 400 
Ala Pro Tyr Asn Val Met Val Leu Ile Asn Thr Phe Cys Ala Pro Cys 
                405                 410                 415     
Ile Pro Asn Thr Val Trp Thr Ile Gly Tyr Trp Leu Cys Tyr Ile Asn 
            420                 425                 430         
Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys 
        435                 440                 445             
Lys Thr Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala 
    450                 455                 460                 
Thr Arg 
465     

<210> 19
<211> 31
<212> DNA
<213> Artificial Sequence

<223> "Primer"

<220> 
<223> Primer

<400> 19
atagatatca tgaataactc aacaaactcc t                                   31


<210> 20
<211> 30
<212> DNA
<213> Artificial Sequence

<223> "Primer"

<220> 
<223> Primer

<400> 20
atagaattcc cttgtagcgc ctatgttctt                                     30


<210> 21
<211> 3051
<212> DNA
<213> Homo sapiens


<400> 21
atgaataact caacaaactc ctctaacaat agcctggctc ttacaagtcc ttataagaca      60

tttgaagtgg tgtttattgt cctggtggct ggatccctca gtttggtgac cattatcggg     120

aacatcctag tcatggtttc cattaaagtc aaccgccacc tccagaccgt caacaattac     180

tttttattca gcttggcctg tgctgacctt atcataggtg ttttctccat gaacttgtac     240

accctctaca ctgtgattgg ttactggcct ttgggacctg tggtgtgtga cctttggcta     300

gccctggact atgtggtcag caatgcctca gttatgaatc tgctcatcat cagctttgac     360

aggtacttct gtgtcacaaa acctctgacc tacccagtca agcggaccac aaaaatggca     420

ggtatgatga ttgcagctgc ctgggtcctc tctttcatcc tctgggctcc agccattctc     480

ttctggcagt tcattgtagg ggtgagaact gtggaggatg gggagtgcta cattcagttt     540

ttttccaatg ctgctgtcac ctttggtacg gctattgcag ccttctattt gccagtgatc     600

atcatgactg tgctatattg gcacatatcc cgagccagca agagcaggat aaagaaggac     660

aagaaggagc ctgttgccaa ccaagacccc gtttctccaa gtctggtaca aggaaggata     720

gtgaagccaa acaataacaa catgcccagc agtgacgatg gcctggagca caacaaaatc     780

cagaatggca aagcccccag ggatcctgtg actgaaaact gtgttcaggg agaggagaag     840

gagagctcca atgactccac ctcagtcagt gctgttgcct ctaatatgag agatgatgaa     900

ataacccagg atgaaaacac agtttccact tccctgggcc attccaaaga tgagaactct     960

aagcaaacat gcatcagaat tggcaccaag accccaaaaa gtgactcatg taccccaact    1020

aataccaccg tggaggtagt ggggtcttca ggtcagaatg gagatgaaaa gcagaatatt    1080

gtagcccgca agattgtgaa gatgactaag cagcctgcaa aaaagaagcc tcctccttcc    1140

cgggaaaaga aagtcaccag gacaatcttg gctattctgt tggctttcat catcacttgg    1200

gccccataca atgtcatggt gctcattaac accttttgtg caccttgcat ccccaacact    1260

gtgtggacaa ttggttactg gctttgttac atcaacagca ctatcaaccc tgcctgctat    1320

gcactttgca atgccacctt caagaagacc tttaaacacc ttctcatgtg tcattataag    1380

aacataggcg ctacaagggt caccgacgcc aaaaacataa agaaaggccc ggcgccattc    1440

tatccgctgg aagatggaac cgctggagag caactgcata aggctatgaa gagatacgcc    1500

ctggttcctg gaacaattgc ttttacagat gcacatatcg aggtggacat cacttacgct    1560

gagtacttcg aaatgtccgt tcggttggca gaagctatga aacgatatgg gctgaataca    1620

aatcacagaa tcgtcgtatg cagtgaaaac tctcttcaat tctttatgcc ggtgttgggc    1680

gcgttattta tcggagttgc agttgcgccc gcgaacgaca tttataatga acgtgaattg    1740

ctcaacagta tgggcatttc gcagcctacc gtggtgttcg tttccaaaaa ggggttgcaa    1800

aaaattttga acgtgcaaaa aaagctccca atcatccaaa aaattattat catggattct    1860

aaaacggatt accagggatt tcagtcgatg tacacgttcg tcacatctca tctacctccc    1920

ggttttaatg aatacgattt tgtgccagag tccttcgata gggacaagac aattgcactg    1980

atcatgaact cctctggatc tactggtctg cctaaaggtg tcgctctgcc tcatagaact    2040

gcctgcgtga gattctcgca tgccagagat cctatttttg gcaatcaaat cattccggat    2100

actgcgattt taagtgttgt tccattccat cacggttttg gaatgtttac tacactcgga    2160

tatttgatat gtggatttcg agtcgtctta atgtatagat ttgaagaaga gctgtttctg    2220

aggagccttc aggattacaa gattcaaagt gcgctgctgg tgccaaccct attctccttc    2280

ttcgccaaaa gcactctgat tgacaaatac gatttatcta atttacacga aattgcttct    2340

ggtggcgctc ccctctctaa ggaagtcggg gaagcggttg ccaagaggtt ccatctgcca    2400

ggtatcaggc aaggatatgg gctcactgag actacatcag ctattctgat tacacccgag    2460

ggggatgata aaccgggcgc ggtcggtaaa gttgttccat tttttgaagc gaaggttgtg    2520

gatctggata ccgggaaaac gctgggcgtt aatcaaagag gcgaactgtg tgtgagaggt    2580

cctatgatta tgtccggtta tgtaaacaat ccggaagcga ccaacgcctt gattgacaag    2640

gatggatggc tacattctgg agacatagct tactgggacg aagacgaaca cttcttcatc    2700

gttgaccgcc tgaagtctct gattaagtac aaaggctatc aggtggctcc cgctgaattg    2760

gaatccatct tgctccaaca ccccaacatc ttcgacgcag gtgtcgcagg tcttcccgac    2820

gatgacgccg gtgaacttcc cgccgccgtt gttgttttgg agcacggaaa gacgatgacg    2880

gaaaaagaga tcgtggatta cgtcgccagt caagtaacaa ccgcgaaaaa gttgcgcgga    2940

ggagttgtgt ttgtggacga agtaccgaaa ggtcttaccg gaaaactcga cgcaagaaaa    3000

atcagagaga tcctcataaa ggccaagaag ggcggaaaga tcgccgtgta a             3051


<210> 22
<211> 1016
<212> PRT
<213> Homo sapiens


<400> 22
Met Asn Asn Ser Thr Asn Ser Ser Asn Asn Ser Leu Ala Leu Thr Ser 
1               5                   10                  15      
Pro Tyr Lys Thr Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser 
            20                  25                  30          
Leu Ser Leu Val Thr Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile 
        35                  40                  45              
Lys Val Asn Arg His Leu Gln Thr Val Asn Asn Tyr Phe Leu Phe Ser 
    50                  55                  60                  
Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr 
65                  70                  75                  80  
Thr Leu Tyr Thr Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys 
                85                  90                  95      
Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met 
            100                 105                 110         
Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Thr Lys Pro 
        115                 120                 125             
Leu Thr Tyr Pro Val Lys Arg Thr Thr Lys Met Ala Gly Met Met Ile 
    130                 135                 140                 
Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu 
145                 150                 155                 160 
Phe Trp Gln Phe Ile Val Gly Val Arg Thr Val Glu Asp Gly Glu Cys 
                165                 170                 175     
Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Thr Phe Gly Thr Ala Ile 
            180                 185                 190         
Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Thr Val Leu Tyr Trp His 
        195                 200                 205             
Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Asp Lys Lys Glu Pro 
    210                 215                 220                 
Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile 
225                 230                 235                 240 
Val Lys Pro Asn Asn Asn Asn Met Pro Ser Ser Asp Asp Gly Leu Glu 
                245                 250                 255     
His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Pro Val Thr Glu 
            260                 265                 270         
Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Thr Ser 
        275                 280                 285             
Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Thr Gln Asp 
    290                 295                 300                 
Glu Asn Thr Val Ser Thr Ser Leu Gly His Ser Lys Asp Glu Asn Ser 
305                 310                 315                 320 
Lys Gln Thr Cys Ile Arg Ile Gly Thr Lys Thr Pro Lys Ser Asp Ser 
                325                 330                 335     
Cys Thr Pro Thr Asn Thr Thr Val Glu Val Val Gly Ser Ser Gly Gln 
            340                 345                 350         
Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met 
        355                 360                 365             
Thr Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys 
    370                 375                 380                 
Val Thr Arg Thr Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp 
385                 390                 395                 400 
Ala Pro Tyr Asn Val Met Val Leu Ile Asn Thr Phe Cys Ala Pro Cys 
                405                 410                 415     
Ile Pro Asn Thr Val Trp Thr Ile Gly Tyr Trp Leu Cys Tyr Ile Asn 
            420                 425                 430         
Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys 
        435                 440                 445             
Lys Thr Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala 
    450                 455                 460                 
Thr Arg Val Thr Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe 
465                 470                 475                 480 
Tyr Pro Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met 
                485                 490                 495     
Lys Arg Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His 
            500                 505                 510         
Ile Glu Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg 
        515                 520                 525             
Leu Ala Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile 
    530                 535                 540                 
Val Val Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly 
545                 550                 555                 560 
Ala Leu Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn 
                565                 570                 575     
Glu Arg Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val 
            580                 585                 590         
Phe Val Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys 
        595                 600                 605             
Leu Pro Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr 
    610                 615                 620                 
Gln Gly Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro 
625                 630                 635                 640 
Gly Phe Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys 
                645                 650                 655     
Thr Ile Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys 
            660                 665                 670         
Gly Val Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala 
        675                 680                 685             
Arg Asp Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu 
    690                 695                 700                 
Ser Val Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly 
705                 710                 715                 720 
Tyr Leu Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu 
                725                 730                 735     
Glu Leu Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu 
            740                 745                 750         
Leu Val Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp 
        755                 760                 765             
Lys Tyr Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro 
    770                 775                 780                 
Leu Ser Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro 
785                 790                 795                 800 
Gly Ile Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu 
                805                 810                 815     
Ile Thr Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val 
            820                 825                 830         
Pro Phe Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu 
        835                 840                 845             
Gly Val Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met 
    850                 855                 860                 
Ser Gly Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys 
865                 870                 875                 880 
Asp Gly Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu 
                885                 890                 895     
His Phe Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly 
            900                 905                 910         
Tyr Gln Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro 
        915                 920                 925             
Asn Ile Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly 
    930                 935                 940                 
Glu Leu Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr 
945                 950                 955                 960 
Glu Lys Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys 
                965                 970                 975     
Lys Leu Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu 
            980                 985                 990         
Thr Gly Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala 
        995                 1000                1005            
Lys Lys Gly Gly Lys Ile Ala Val 
    1010                1015    

<210> 23
<211> 30
<212> DNA
<213> Artificial Sequence

<223> "Primer"

<220> 
<223> Primer

<400> 23
ataggatcca tggggcaacc cgggaacggc                                     30


<210> 24
<211> 70
<212> DNA
<213> Artificial Sequence

<223> "Primer"

<220> 
<223> Primer

<400> 24
ataaagctta atctcggttc tctgggtgac cctgcctatg ctgacccagc agtgagtcat     60

ttgtactaca                                                            70


