
<110>  MedImmune Ltd
 
<120>  BLOOD BRAIN BARRIER TRANSPORT MOLECULES AND USES THEREOF
<130>  BBB-100WO1

<160>	198

<170>  PatentIn version 3.5

<210>	1
<211>	366
<212>	DNA
<213>	Homo sapiens

<220>
<223>	Bbbt0241  VH

<400>	1
gaagttcaac tgcaggcgtc cggcggtggc ctggtgcagg ctggcggctc tctgcgtctg      60

tcctgtgctg ccagcggctt taaaatcact cactatacta tgggctggtt ccgccaggca     120

ccgggcaaag agcgtgaatt cgtgagccgc atcacctggg gcggtgacaa caccttttac     180

tccaactccg ttaagggtcg ttttactatc tctcgtgata acgctaaaaa caccgtttac     240

ctgcagatga acagcctgaa accagaggac actgctgact actattgtgc tgcaggttcc     300

acctctacgg ctaccccact gcgcgtcgac tattggggca aaggcaccca ggtgaccgtc     360

tcgagt                                                                366


<210>	2
<211>	122
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0241  VH

<400>	2
Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
                5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          

Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              

Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp Tyr Tyr Cys 
                85                  90                  95      

Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg Val Asp Tyr Trp 
            100                 105                 110         

Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>	3
<211>	5
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0241  VH CDR1

<400>	3
His Tyr Thr Met Gly 
                5   


<210>	4
<211>	17
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0241  VH CDR2

<400>	4
Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val Lys 
                5                   10                  15      

Gly 
    


<210>	5
<211>	13
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0241  VH CDR3

<400>	5
Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg Val Asp Tyr 
                5                   10              


<210>	6
<211>	30
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0241  VH FW1

<400>	6
Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
                5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr 
            20                  25                  30  


<210>	7
<211>	14
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0241  VH FW2

<400>	7
Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser 
                5                   10                  


<210>	8
<211>	32
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0241  VH FW3

<400>	8
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
                5                   10                  15      

Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>	9
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0241  VH FW4

<400>	9
Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
                5                   10      


<210>	10
<211>	324
<212>	DNA
<213>	Homo sapiens

<220>
<223>	Bbbt0241  VL

<400>	10
gaaacgacac tcacgcagtc tccagacacc ctgtctttgt ctccagggga aagagccacc      60

ctctcctgcc gggccagtca gagtcttagc aacaacttct tagcctggta ccagcagaaa     120

tctggccagg ctcccaggct cctcatctat gctgcatcca gcagggccac tggcatccca     180

gacagattca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag     240

cctgaagatt ttgcagttta ttactgtcag cagtatgctg cctcagcgat caccttcggc     300

caagggacac gactggagat taaa                                            324


<210>	11
<211>	108
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0241  VL

<400>	11
Glu Thr Thr Leu Thr Gln Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly 
                5                   10                  15      

Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Ser Asn Asn 
            20                  25                  30          

Phe Leu Ala Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              

Ile Tyr Ala Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  

Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  

Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ala Ala Ser Ala 
                85                  90                  95      

Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>	12
<211>	12
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0241  VL CDR1

<400>	12
Arg Ala Ser Gln Ser Leu Ser Asn Asn Phe Leu Ala 
                5                   10          


<210>	13
<211>	7
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0241 VL CDR2

<400>	13
Ala Ala Ser Ser Arg Ala Thr 
                5           


<210>	14
<211>	9
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0241  VL CDR3

<400>	14
Gln Gln Tyr Ala Ala Ser Ala Ile Thr 
                5                   


<210>	15
<211>	23
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0241  VL FW1

<400>	15
Glu Thr Thr Leu Thr Gln Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly 
                5                   10                  15      

Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>	16
<211>	15
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0241  VL FW2

<400>	16
Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
                5                   10                  15  


<210>	17
<211>	32
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0241  VL FW3

<400>	17
Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                5                   10                  15      

Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>	18
<211>	10
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0241  VL FW4

<400>	18
Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
                5                   10  


<210>	19
<211>	369
<212>	DNA
<213>	Homo sapiens

<220>
<223>	Bbbt0626  VH

<400>	19
ggggtccagc tggtgcagtc tggggcagag ctgaagaagc ctgggtcctc ggtgaaggtc      60

tcctgtaagg cttctggagg caccttcagc agttatgcta tcagctgggt gcgacaggcc     120

cctggacaag ggcttgagtg gatgggaagg atcatcccta ttcttggtac atcaaactac     180

gcacagaagt tccagggcag agtcacgatt accgcggacg aacgtacgag cacagcctac     240

atggagctga gcagcctgag atctgaggac acggccgtat attactgtgc gagaaggagt     300

agtttagcag cagcggatag gggggctttt gatatctggg gccaggggac aatggtcacc     360

gtctcgagt                                                             369


<210>	20
<211>	123
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0626  VH

<400>	20
Gly Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ser 
                5                   10                  15      

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          

Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              

Gly Arg Ile Ile Pro Ile Leu Gly Thr Ser Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  

Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Arg Thr Ser Thr Ala Tyr 
65                  70                  75                  80  

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Arg Ser Ser Leu Ala Ala Ala Asp Arg Gly Ala Phe Asp Ile 
            100                 105                 110         

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>	21
<211>	5
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0626  VH CDR1

<400>	21
Ser Tyr Ala Ile Ser 
                5   


<210>	22
<211>	17
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0626 VH CDR2

<400>	22
Arg Ile Ile Pro Ile Leu Gly Thr Ser Asn Tyr Ala Gln Lys Phe Gln 
                5                   10                  15      

Gly 
    


<210>	23
<211>	14
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0626 VH CDR3

<400>	23
Arg Ser Ser Leu Ala Ala Ala Asp Arg Gly Ala Phe Asp Ile 
                5                   10                  


<210>	24
<211>	30
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0626  VH FW1

<400>	24
Gly Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ser 
                5                   10                  15      

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser 
            20                  25                  30  


<210>	25
<211>	14
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0626  VH FW2

<400>	25
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                5                   10                  


<210>	26
<211>	32
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0626  VH FW3

<400>	26
Arg Val Thr Ile Thr Ala Asp Glu Arg Thr Ser Thr Ala Tyr Met Glu 
                5                   10                  15      

Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>	27
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0626  VH FW4

<400>	27
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
                5                   10      


<210>	28
<211>	324
<212>	DNA
<213>	Homo sapiens

<220>
<223>	Bbbt0626  VL

<400>	28
tcgtctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc      60

acatgccaag gagacagcct cagaagctat tatgcaagct ggtaccagca gaagccagga     120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga     180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa     240

gatgaggctg actattactg taactcccgg gacagcagtg gtaaccatgt ggtattcggc     300

ggagggacca agctgaccgt ccta                                            324


<210>	29
<211>	108
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0626  VL

<400>	29
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
                5                   10                  15      

Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          

Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              

Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  

Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  

Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      

Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>	30
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0626  VL CDR1

<400>	30
Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
                5                   10      


<210>	31
<211>	7
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0626  VL CDR2

<400>	31
Gly Lys Asn Asn Arg Pro Ser 
                5           


<210>	32
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0626  VL CDR3

<400>	32
Asn Ser Arg Asp Ser Ser Gly Asn His Val Val 
                5                   10      


<210>	33
<211>	22
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0626  VL FW1

<400>	33
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
                5                   10                  15      

Thr Val Arg Ile Thr Cys 
            20          


<210>	34
<211>	15
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0626  VL FW2

<400>	34
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
                5                   10                  15  


<210>	35
<211>	32
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0626  VL FW3

<400>	35
Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser 
                5                   10                  15      

Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>	36
<211>	10
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0626  VL FW4

<400>	36
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                5                   10  


<210>	37
<211>	366
<212>	DNA
<213>	Homo sapiens

<220>
<223>	Bbbt0632 VH

<400>	37
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc      60

tcctgcaaga cttctggagg caccttcggc acctattcta tcacctgggt gcgacaggcc     120

cctggacaag ggcttgagtg gatgggagac atcgtcccta tctttggaac accaaactac     180

gcacagaatt tccagggcag agtcactatc tccgcggacg tatccacggc gacagtctac     240

atggagctga gcagcctaac atccgacgac acggccgtct acttctgtgc taagaggggg     300

agttactacg gccggggagg ttggttcgac ccctggggcc gggggacaat ggtcaccgtc     360

tcgagt                                                                366


<210>	38
<211>	122
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0632  VH

<400>	38
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
                5                   10                  15      

Ser Val Lys Val Ser Cys Lys Thr Ser Gly Gly Thr Phe Gly Thr Tyr 
            20                  25                  30          

Ser Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              

Gly Asp Ile Val Pro Ile Phe Gly Thr Pro Asn Tyr Ala Gln Asn Phe 
    50                  55                  60                  

Gln Gly Arg Val Thr Ile Ser Ala Asp Val Ser Thr Ala Thr Val Tyr 
65                  70                  75                  80  

Met Glu Leu Ser Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      

Ala Lys Arg Gly Ser Tyr Tyr Gly Arg Gly Gly Trp Phe Asp Pro Trp 
            100                 105                 110         

Gly Arg Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>	39
<211>	5
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0632  VH CDR1

<400>	39
Thr Tyr Ser Ile Thr 
                5   


<210>	40
<211>	17
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0632  VH CDR2

<400>	40
Asp Ile Val Pro Ile Phe Gly Thr Pro Asn Tyr Ala Gln Asn Phe Gln 
                5                   10                  15      

Gly 
    


<210>	41
<211>	13
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0632  VH CDR3

<400>	41
Arg Gly Ser Tyr Tyr Gly Arg Gly Gly Trp Phe Asp Pro 
                5                   10              


<210>	42
<211>	30
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0632  VH FW1

<400>	42
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
                5                   10                  15      

Ser Val Lys Val Ser Cys Lys Thr Ser Gly Gly Thr Phe Gly 
            20                  25                  30  


<210>	43
<211>	14
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0632  VH FW2

<400>	43
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                5                   10                  


<210>	44
<211>	32
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0632  VH FW3

<400>	44
Arg Val Thr Ile Ser Ala Asp Val Ser Thr Ala Thr Val Tyr Met Glu 
                5                   10                  15      

Leu Ser Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Phe Cys Ala Lys 
            20                  25                  30          


<210>	45
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0632  VH FW4

<400>	45
Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser 
                5                   10      


<210>	46
<211>	324
<212>	DNA
<213>	Homo sapiens

<220>
<223>	Bbbt0632  VL

<400>	46
tcttctgagc tgactcagga ccctgctgtg tctgtggcct tgagacagac agtcaggatc      60

acatgccaag gagacagcct cacaaggtat tatacaaact ggtaccagca gaagccagga     120

caggccccta tacttgtcat ctatggtgaa aacaaccggc cctcagggat cccagaccga     180

ttctctggct ccagatcagg aaacacagct tccttgacca tcactggggc tcaggcggaa     240

gatgaggctg actattactg taactcccgg gacaatactg gtaaacattg ggtgttcggc     300

ggagggacca agctgaccgt ccta                                            324


<210>	47
<211>	108
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0632  VL

<400>	47
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Arg Gln 
                5                   10                  15      

Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Thr Arg Tyr Tyr Thr 
            20                  25                  30          

Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ile Leu Val Ile Tyr 
        35                  40                  45              

Gly Glu Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  

Arg Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  

Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Asn Thr Gly Lys His 
                85                  90                  95      

Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>	48
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0632  VL CDR1

<400>	48
Gln Gly Asp Ser Leu Thr Arg Tyr Tyr Thr Asn 
                5                   10      


<210>	49
<211>	7
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0632  VL CDR2

<400>	49
Gly Glu Asn Asn Arg Pro Ser 
                5           


<210>	50
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0632  VL CDR3

<400>	50
Asn Ser Arg Asp Asn Thr Gly Lys His Trp Val 
                5                   10      


<210>	51
<211>	22
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0632  VL FW1

<400>	51
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Arg Gln 
                5                   10                  15      

Thr Val Arg Ile Thr Cys 
            20          


<210>	52
<211>	15
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0632  VL FW2

<400>	52
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ile Leu Val Ile Tyr 
                5                   10                  15  


<210>	53
<211>	32
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0632  VL FW3

<400>	53
Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Asn Thr Ala Ser 
                5                   10                  15      

Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>	54
<211>	10
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0632  VL FW4

<400>	54
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                5                   10  


<210>	55
<211>	384
<212>	DNA
<213>	Homo sapiens

<220>
<223>	Bbbt0654  VH

<400>	55
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc      60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac     180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gaaaaattat     300

tactatgata ctagtgctta ttactacgta gggtccgact actttgacta ctggggccaa     360

gggacaatgg tcaccgtctc gagt                                            384


<210>	56
<211>	128
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0654 VH

<400>	56
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Lys Asn Tyr Tyr Tyr Asp Thr Ser Ala Tyr Tyr Tyr Val Gly Ser 
            100                 105                 110         

Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125             


<210>	57
<211>	5
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0654  VH CDR1

<400>	57
Ser Tyr Ala Met Ser 
                5   


<210>	58
<211>	17
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0654  VH CDR2

<400>	58
Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
                5                   10                  15      

Gly 
    


<210>	59
<211>	19
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0654  VH CDR3

<400>	59
Asn Tyr Tyr Tyr Asp Thr Ser Ala Tyr Tyr Tyr Val Gly Ser Asp Tyr 
                5                   10                  15      

Phe Asp Tyr 
            


<210>	60
<211>	30
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0654  VH FW1

<400>	60
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>	61
<211>	14
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0654  VH FW2

<400>	61
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                5                   10                  


<210>	62
<211>	32
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0654  VH FW3

<400>	62
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
                5                   10                  15      

Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>	63
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0654  VH FW 4

<400>	63
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
                5                   10      


<210>	64
<211>	330
<212>	DNA
<213>	Homo sapiens

<220>
<223>	Bbbt0654  VL

<400>	64
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gataaccatc      60

tcctgcactg caaccagcag taacgttggc gcttataact ttgtctcctg gtaccaacaa     120

cacccaggca aagcccccaa agtcctgatt tatagggtca gtaatcggcc ttcaggggtt     180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc     240

caggctgacg acgaggctga ttattattgc agctcatata caaccgacta catttgggtg     300

ttcggcggag ggaccaagct gaccgtccta                                      330


<210>	65
<211>	110
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0654  VL

<400>	65
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
                5                   10                  15      

Ser Ile Thr Ile Ser Cys Thr Ala Thr Ser Ser Asn Val Gly Ala Tyr 
            20                  25                  30          

Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Val 
        35                  40                  45              

Leu Ile Tyr Arg Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  

Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Thr Asp 
                85                  90                  95      

Tyr Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>	66
<211>	14
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0654  VL CDR1

<400>	66
Thr Ala Thr Ser Ser Asn Val Gly Ala Tyr Asn Phe Val Ser 
                5                   10                  


<210>	67
<211>	7
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0654  VL CDR2

<400>	67
Arg Val Ser Asn Arg Pro Ser 
                5           


<210>	68
<211>	10
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0654  VL CDR3

<400>	68
Ser Ser Tyr Thr Thr Asp Tyr Ile Trp Val 
                5                   10  


<210>	69
<211>	22
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0654  VL FW1

<400>	69
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
                5                   10                  15      

Ser Ile Thr Ile Ser Cys 
            20          


<210>	70
<211>	15
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0654  VL FW2

<400>	70
Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Val Leu Ile Tyr 
                5                   10                  15  


<210>	71
<211>	32
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0654  VL FW3

<400>	71
Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 
                5                   10                  15      

Leu Thr Ile Ser Gly Leu Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>	72
<211>	10
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0654  VL FW4

<400>	72
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                5                   10  


<210>	73
<211>	360
<212>	DNA
<213>	Homo sapiens

<220>
<223>	Bbbt0726  VH

<400>	73
caggtacagc tgcagcagtc aggggctgag gtgaagaagc ctgggtcctc ggtgagggtc      60

tcctgcaagg cttctggagg caccttcaac agttatgcta tcaactgggt gcgacaggcc     120

cctggacaag ggcttgagtg gatgggaggg atcatcactt tctttggtac aacaacctac     180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac     240

atggagctga gcagcctgag atctgacgac acggccgtgt attattgtgc gaggaatccc     300

cgtattgtgg gcggagcttt tgatatctgg gggaaaggga ccacggtcac cgtctcgagt     360


<210>	74
<211>	120
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0726  VH

<400>	74
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
                5                   10                  15      

Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Ser Tyr 
            20                  25                  30          

Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              

Gly Gly Ile Ile Thr Phe Phe Gly Thr Thr Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  

Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  

Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Asn Pro Arg Ile Val Gly Gly Ala Phe Asp Ile Trp Gly Lys 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>	75
<211>	5
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0726  VH CDR1

<400>	75
Ser Tyr Ala Ile Asn 
                5   


<210>	76
<211>	17
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0726  VH CDR2

<400>	76
Gly Ile Ile Thr Phe Phe Gly Thr Thr Thr Tyr Ala Gln Lys Phe Gln 
                5                   10                  15      

Gly 
    


<210>	77
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0726  VH CDR3

<400>	77
Asn Pro Arg Ile Val Gly Gly Ala Phe Asp Ile 
                5                   10      


<210>	78
<211>	30
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0726  VH FW1

<400>	78
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
                5                   10                  15      

Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn 
            20                  25                  30  


<210>	79
<211>	14
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0726  VH FW2

<400>	79
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                5                   10                  


<210>	80
<211>	32
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0726  VH FW3

<400>	80
Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
                5                   10                  15      

Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>	81
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0726  VH FW4

<400>	81
Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
                5                   10      


<210>	82
<211>	324
<212>	DNA
<213>	Homo sapiens

<220>
<223>	Bbbt0726  VL

<400>	82
tcgtctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc      60

acatgccaag gagacagcct cagaagctat tatgcaagct ggtaccagca gaagccagga     120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcaggggt cccagaccga     180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa     240

gatgaggctg actattactg taactcccgg gacagcagtg gtaaccatgt ggtattcggc     300

ggagggacca agctgaccgt ccta                                            324


<210>	83
<211>	108
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0726  VL

<400>	83
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
                5                   10                  15      

Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          

Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              

Gly Lys Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  

Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  

Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      

Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>	84
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0726  VL CDR1

<400>	84
Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
                5                   10      


<210>	85
<211>	7
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0726  VL CDR2

<400>	85
Gly Lys Asn Asn Arg Pro Ser 
                5           


<210>	86
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0726  VL CDR3

<400>	86
Asn Ser Arg Asp Ser Ser Gly Asn His Val Val 
                5                   10      


<210>	87
<211>	22
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0726  VL FW1

<400>	87
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
                5                   10                  15      

Thr Val Arg Ile Thr Cys 
            20          


<210>	88
<211>	15
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0726 VL FW2

<400>	88
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
                5                   10                  15  


<210>	89
<211>	32
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0726 VL FW3

<400>	89
Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser 
                5                   10                  15      

Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>	90
<211>	10
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0726  VL FW4

<400>	90
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                5                   10  


<210>	91
<211>	357
<212>	DNA
<213>	Homo sapiens

<220>
<223>	Bbbt0727  VH

<400>	91
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc      60

tcctgcaagg cttctggaga cactttccgc agctatatta tcagctgggt gcgacaggcc     120

cctggacaag gacttgagtg ggtgggaggg atcatcccta tgtttggcac atcaaattat     180

gcacagcagt tccagggcaa agtcaccatt accgcggacg aatccacgag cacagcctac     240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggtggg     300

gcccgatact actacatgga cgtctggggc cgagggacaa tggtcaccgt ctcttca        357


<210>	92
<211>	119
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0727  VH

<400>	92
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
                5                   10                  15      

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Arg Ser Tyr 
            20                  25                  30          

Ile Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              

Gly Gly Ile Ile Pro Met Phe Gly Thr Ser Asn Tyr Ala Gln Gln Phe 
    50                  55                  60                  

Gln Gly Lys Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Gly Gly Ala Arg Tyr Tyr Tyr Met Asp Val Trp Gly Arg Gly 
            100                 105                 110         

Thr Met Val Thr Val Ser Ser 
        115                 


<210>	93
<211>	5
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0727  VH CDR1

<400>	93
Ser Tyr Ile Ile Ser 
                5   


<210>	94
<211>	17
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0727  VH CDR2

<400>	94
Gly Ile Ile Pro Met Phe Gly Thr Ser Asn Tyr Ala Gln Gln Phe Gln 
                5                   10                  15      

Gly 
    


<210>	95
<211>	10
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0727  VH CDR3

<400>	95
Gly Gly Ala Arg Tyr Tyr Tyr Met Asp Val 
                5                   10  


<210>	96
<211>	30
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0727  VH FW1

<400>	96
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
                5                   10                  15      

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Arg 
            20                  25                  30  


<210>	97
<211>	14
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0727  VH FW2

<400>	97
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val Gly 
                5                   10                  


<210>	98
<211>	32
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0727  VH FW3

<400>	98
Lys Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
                5                   10                  15      

Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>	99
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0727  VH FW4

<400>	99
Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser 
                5                   10      


<210>	100
<211>	324
<212>	DNA
<213>	Homo sapiens

<220>
<223>	Bbbt0727  VL

<400>	100
tcgtctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc      60

acatgccaag gagacagcct cagaagctat tatgcaagct ggtaccagca gaagccagga     120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga     180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa     240

gatgaggctg actattactg taactcccgg gacagcagtg gtaaccatgt ggtattcggc     300

ggagggacca agctgaccgt ccta                                            324


<210>	101
<211>	108
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0727  VL

<400>	101
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
                5                   10                  15      

Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          

Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              

Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  

Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  

Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      

Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>	102
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0727  VL CDR1

<400>	102
Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
                5                   10      


<210>	103
<211>	7
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0727  VL CDR2

<400>	103
Gly Lys Asn Asn Arg Pro Ser 
                5           


<210>	104
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0727  VL CDR3

<400>	104
Asn Ser Arg Asp Ser Ser Gly Asn His Val Val 
                5                   10      


<210>	105
<211>	22
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0727  VL FW1

<400>	105
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
                5                   10                  15      

Thr Val Arg Ile Thr Cys 
            20          


<210>	106
<211>	15
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0727  VL FW2

<400>	106
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
                5                   10                  15  


<210>	107
<211>	32
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0727  VL FW3

<400>	107
Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser 
                5                   10                  15      

Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>	108
<211>	10
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0727  VL FW4

<400>	108
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                5                   10  


<210>	109
<211>	360
<212>	DNA
<213>	Homo sapiens

<220>
<223>	Bbbt0732  VH

<400>	109
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc      60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac     180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gaaacgtcgg     300

agggactact actacgatat ggacgtctgg ggccaaggga caatggtcac cgtctcgagt     360


<210>	110
<211>	120
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0732  VH

<400>	110
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Lys Arg Arg Arg Asp Tyr Tyr Tyr Asp Met Asp Val Trp Gly Gln 
            100                 105                 110         

Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>	111
<211>	5
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0732  VH CDR1

<400>	111
Ser Tyr Ala Met Ser 
                5   


<210>	112
<211>	17
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0732  VH CDR2

<400>	112
Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
                5                   10                  15      

Gly 
    


<210>	113
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0732  VH CDR3

<400>	113
Arg Arg Arg Asp Tyr Tyr Tyr Asp Met Asp Val 
                5                   10      


<210>	114
<211>	30
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0732  VH FW1

<400>	114
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>	115
<211>	14
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0732  VH FW2

<400>	115
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                5                   10                  


<210>	116
<211>	32
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0732  VH FW 3

<400>	116
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
                5                   10                  15      

Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>	117
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0732  VH FW4

<400>	117
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
                5                   10      


<210>	118
<211>	324
<212>	DNA
<213>	Homo sapiens

<220>
<223>	Bbbt0732  VL

<400>	118
tcttctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc      60

acatgccaag gagacagcct cagaacctat tatgcaagct ggtaccagca caagccagga     120

caggcccctg tacttgtcat gtatggtaaa gataaccgac cctcagggat cccagaccga     180

ttctctggct ccagctcagg aaccacagct tccttgacca tcactggggc tcaggcggaa     240

gatgaggctg actattactg taactcccgg gacagcagtg gtcaccctgt ggtattcggc     300

ggagggacca agctgaccgt ccta                                            324


<210>	119
<211>	108
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0732  VL 

<400>	119
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
                5                   10                  15      

Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 
            20                  25                  30          

Ser Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Val Leu Val Met Tyr 
        35                  40                  45              

Gly Lys Asp Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  

Ser Ser Gly Thr Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  

Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly His Pro 
                85                  90                  95      

Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>	120
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0732  VL CDR1

<400>	120
Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala Ser 
                5                   10      


<210>	121
<211>	7
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0732 VL CDR2

<400>	121
Gly Lys Asp Asn Arg Pro Ser 
                5           


<210>	122
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0732  VL CDR3

<400>	122
Asn Ser Arg Asp Ser Ser Gly His Pro Val Val 
                5                   10      


<210>	123
<211>	22
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0732 VL FW1

<400>	123
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
                5                   10                  15      

Thr Val Arg Ile Thr Cys 
            20          


<210>	124
<211>	15
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0732  VL FW2

<400>	124
Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Val Leu Val Met Tyr 
                5                   10                  15  


<210>	125
<211>	32
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0732  VL FW3

<400>	125
Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Thr Thr Ala Ser 
                5                   10                  15      

Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>	126
<211>	10
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0732  VL FW4

<400>	126
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                5                   10  


<210>	127
<211>	366
<212>	DNA
<213>	Homo sapiens

<220>
<223>	Bbbt0754  VH

<400>	127
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc      60

tcctgtgcag cctctggatt caaaattacc cactatacta tgggctgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcacgc atcacgtggg gcggtgacaa caccttttac     180

tccaactccg tgaggggccg gttcaccatc tccagagaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc aacagggacg     300

ttcggggagt tattccccga ctactttaag tattggggcc gggggacaat ggtcaccgtc     360

tcgagt                                                                366


<210>	128
<211>	122
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0754  VH

<400>	128
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          

Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  

Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Thr Gly Thr Phe Gly Glu Leu Phe Pro Asp Tyr Phe Lys Tyr Trp 
            100                 105                 110         

Gly Arg Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>	129
<211>	5
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0754  VH CDR1

<400>	129
His Tyr Thr Met Gly 
                5   


<210>	130
<211>	17
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0754  VH CDR2

<400>	130
Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val Arg 
                5                   10                  15      

Gly 
    


<210>	131
<211>	13
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0754  VH CDR3

<400>	131
Gly Thr Phe Gly Glu Leu Phe Pro Asp Tyr Phe Lys Tyr 
                5                   10              


<210>	132
<211>	30
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0754  VH FW1

<400>	132
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr 
            20                  25                  30  


<210>	133
<211>	14
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0754  VH FW2

<400>	133
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                5                   10                  


<210>	134
<211>	32
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0754  VH FW3

<400>	134
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
                5                   10                  15      

Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr 
            20                  25                  30          


<210>	135
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0754  VH FW4

<400>	135
Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser 
                5                   10      


<210>	136
<211>	333
<212>	DNA
<213>	Homo sapiens

<220>
<223>	Bbbt0754  VL

<400>	136
caggctgtgc tgactcagcc gtcctcagtg tctggggccc cagggcagag ggtcaccatc      60

ccctgcactg ggagcagctc caacatcggg gcaggttatg atgtaaactg gtaccagcag     120

cttccaggaa cagcccccaa actcctcatc tttcataaca acattcggcc ctcaggggtc     180

cctgaccgat tctctggctc caagtctggc acctcagtct ccctggccat cactgggctc     240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtgcttgg     300

gtcttcggcg gagggaccaa ggtcaccgtc cta                                  333


<210>	137
<211>	111
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0754  VL

<400>	137
Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly Ala Pro Gly Gln 
                5                   10                  15      

Arg Val Thr Ile Pro Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          

Tyr Asp Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              

Leu Ile Phe His Asn Asn Ile Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Gly Thr Ser Val Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      

Leu Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>	138
<211>	14
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0754  VL CDR1

<400>	138
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val Asn 
                5                   10                  


<210>	139
<211>	7
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0754  VL CDR2

<400>	139
His Asn Asn Ile Arg Pro Ser 
                5           


<210>	140
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0754  VL CDR3

<400>	140
Gln Ser Tyr Asp Ser Ser Leu Ser Ala Trp Val 
                5                   10      


<210>	141
<211>	22
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0754  VL FW1

<400>	141
Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly Ala Pro Gly Gln 
                5                   10                  15      

Arg Val Thr Ile Pro Cys 
            20          


<210>	142
<211>	15
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0754  VL FW2

<400>	142
Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Phe 
                5                   10                  15  


<210>	143
<211>	32
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0754  VL FW3

<400>	143
Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Val Ser 
                5                   10                  15      

Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>	144
<211>	10
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0754  VL FW4

<400>	144
Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
                5                   10  


<210>	145
<211>	366
<212>	DNA
<213>	Homo sapiens

<220>
<223>	Bbbt0674  VH

<400>	145
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc      60

tcctgtgcag cctctggatt caaaattacc cactatacta tgggctgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcacgc atcacgtggg gcggtgacaa caccttttac     180

tccaactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagagact     300

acgaacctct accactacta cggtatgaac gactggggcc ggggcaccct ggtcaccgtc     360

tcgagt                                                                366


<210>	146
<211>	122
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0674  VH

<400>	146
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          

Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Lys Glu Thr Thr Asn Leu Tyr His Tyr Tyr Gly Met Asn Asp Trp 
            100                 105                 110         

Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>	147
<211>	5
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0674  VH CDR1

<400>	147
His Tyr Thr Met Gly 
                5   


<210>	148
<211>	17
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0674  VH CDR2

<400>	148
Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val Lys 
                5                   10                  15      

Gly 
    


<210>	149
<211>	13
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0674  VH CDR3

<400>	149
Glu Thr Thr Asn Leu Tyr His Tyr Tyr Gly Met Asn Asp 
                5                   10              


<210>	150
<211>	30
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0674  VH FW1

<400>	150
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr 
            20                  25                  30  


<210>	151
<211>	14
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0674 VH FW2

<400>	151
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                5                   10                  


<210>	152
<211>	32
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0674  VH FW3

<400>	152
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
                5                   10                  15      

Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>	153
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0674  VH FW4

<400>	153
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
                5                   10      


<210>	154
<211>	330
<212>	DNA
<213>	Homo sapiens

<220>
<223>	Bbbt0674  VL

<400>	154
cagtctgtgt tgacgcagcc gccctcagtg tctgggaccc ccgggcagag ggtcaccatc      60

tcttgttatg gaagcagctc cgacatcggc aataatttcg tttactggta ccaacaagtc     120

ccaggaatgg cccccaaact cctcatctac aggagtcatc agcggccctc aggggtctct     180

gaccgatttt caggctccaa gtctggcacc tcagcctccc tggccatcag tggactccgg     240

tccgaggatg aggctgatta ttactgtgca acatggggtg acaatctgcg tggttgggtt     300

ttcggcggag ggaccaagct gaccgtccta                                      330


<210>	155
<211>	110
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0674  VL

<400>	155
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 
                5                   10                  15      

Arg Val Thr Ile Ser Cys Tyr Gly Ser Ser Ser Asp Ile Gly Asn Asn 
            20                  25                  30          

Phe Val Tyr Trp Tyr Gln Gln Val Pro Gly Met Ala Pro Lys Leu Leu 
        35                  40                  45              

Ile Tyr Arg Ser His Gln Arg Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Gly Asp Asn Leu 
                85                  90                  95      

Arg Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>	156
<211>	13
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0674  VL CDR1

<400>	156
Tyr Gly Ser Ser Ser Asp Ile Gly Asn Asn Phe Val Tyr 
                5                   10              


<210>	157
<211>	7
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0674  VL CDR2

<400>	157
Arg Ser His Gln Arg Pro Ser 
                5           


<210>	158
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0674  VL CDR3

<400>	158
Ala Thr Trp Gly Asp Asn Leu Arg Gly Trp Val 
                5                   10      


<210>	159
<211>	22
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0674  VL FW1

<400>	159
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 
                5                   10                  15      

Arg Val Thr Ile Ser Cys 
            20          


<210>	160
<211>	15
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0674  VL FW2

<400>	160
Trp Tyr Gln Gln Val Pro Gly Met Ala Pro Lys Leu Leu Ile Tyr 
                5                   10                  15  


<210>	161
<211>	32
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0674  VL FW3

<400>	161
Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
                5                   10                  15      

Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>	162
<211>	10
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0674  VL FW4

<400>	162
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                5                   10  


<210>	163
<211>	360
<212>	DNA
<213>	Homo sapiens

<220>
<223>	Bbbt0755  VH

<400>	163
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc      60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcacgc atcacgtggg gcggtgacaa caccttttac     180

tccaactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc cagtcattat     300

ggtggctgga tttcactctt tgaccactgg gggcagggga ccacggtcac cgtctcgagt     360


<210>	164
<211>	120
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0755  VH

<400>	164
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Ser His Tyr Gly Gly Trp Ile Ser Leu Phe Asp His Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>	165
<211>	5
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0755  VH CDR1

<400>	165
Ser Tyr Ala Met Ser 
                5   


<210>	166
<211>	17
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0755  VH CDR2

<400>	166
Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val Lys 
                5                   10                  15      

Gly 
    


<210>	167
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0755  VH CDR3

<400>	167
His Tyr Gly Gly Trp Ile Ser Leu Phe Asp His 
                5                   10      


<210>	168
<211>	30
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0755  VH FW1

<400>	168
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>	169
<211>	14
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0755  VH FW2

<400>	169
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                5                   10                  


<210>	170
<211>	32
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0755  VH FW3

<400>	170
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
                5                   10                  15      

Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
            20                  25                  30          


<210>	171
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0755  VH FW4

<400>	171
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                5                   10      


<210>	172
<211>	330
<212>	DNA
<213>	Homo sapiens

<220>
<223>	Bbbt0755  VL

<400>	172
caggctgtgc tgactcagcc gtcctcaatt tctggggccc cagggcagag ggtcaccatc      60

tcctgcactg ggaccagctc caacatcggg gcaggtaatg ctgtacactg gtaccagcag     120

cttccaggaa cagcccccag actcctcatc ttcgctgaca accgtcggcc ctcaggggtc     180

cctgaccgat tctccgcctc caagtctgcc acctcagcct ccctggccat cactgggctc     240

caggttgacg atgaggctga gtattactgc cagtcgtatg acaccaggct gcgtgtggta     300

ttcggcgggg ggaccaaggt caccgtccta                                      330


<210>	173
<211>	110
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0755  VL

<400>	173
Gln Ala Val Leu Thr Gln Pro Ser Ser Ile Ser Gly Ala Pro Gly Gln 
                5                   10                  15      

Arg Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          

Asn Ala Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu 
        35                  40                  45              

Leu Ile Phe Ala Asp Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  

Ser Ala Ser Lys Ser Ala Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  

Gln Val Asp Asp Glu Ala Glu Tyr Tyr Cys Gln Ser Tyr Asp Thr Arg 
                85                  90                  95      

Leu Arg Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>	174
<211>	14
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0755  VL CDR1

<400>	174
Thr Gly Thr Ser Ser Asn Ile Gly Ala Gly Asn Ala Val His 
                5                   10                  


<210>	175
<211>	7
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0755  VL CDR2

<400>	175
Ala Asp Asn Arg Arg Pro Ser 
                5           


<210>	176
<211>	10
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0755  VL CDR3

<400>	176
Gln Ser Tyr Asp Thr Arg Leu Arg Val Val 
                5                   10  


<210>	177
<211>	22
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0755  VL FW1

<400>	177
Gln Ala Val Leu Thr Gln Pro Ser Ser Ile Ser Gly Ala Pro Gly Gln 
                5                   10                  15      

Arg Val Thr Ile Ser Cys 
            20          


<210>	178
<211>	15
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0755  VL FW2

<400>	178
Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu Leu Ile Phe 
                5                   10                  15  


<210>	179
<211>	32
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0755  VL FW3

<400>	179
Gly Val Pro Asp Arg Phe Ser Ala Ser Lys Ser Ala Thr Ser Ala Ser 
                5                   10                  15      

Leu Ala Ile Thr Gly Leu Gln Val Asp Asp Glu Ala Glu Tyr Tyr Cys 
            20                  25                  30          


<210>	180
<211>	10
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0755  VL FW4

<400>	180
Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
                5                   10  


<210>	181
<211>	360
<212>	DNA
<213>	Homo sapiens

<220>
<223>	Bbbt0643  VH

<400>	181
gaggtgcagc tgcaggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc      60

tcctgtgcag cctctggatt caaaattacc cactatacta tgggctgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac     180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagggggt     300

gggactatat cagctcggtt cgacccctgg gggcaaggga ccacggtcac cgtctcgagt     360


<210>	182
<211>	120
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0643  VH

<400>	182
Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          

Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Gly Gly Gly Thr Ile Ser Ala Arg Phe Asp Pro Trp Gly Gln 
            100                 105                 110         

Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>	183
<211>	5
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0643  VH CDR1

<400>	183
His Tyr Thr Met Gly 
                5   


<210>	184
<211>	17
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0643  VH CDR2

<400>	184
Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
                5                   10                  15      

Gly 
    


<210>	185
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0643  VH CDR3

<400>	185
Gly Gly Gly Thr Ile Ser Ala Arg Phe Asp Pro 
                5                   10      


<210>	186
<211>	30
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0643  VH FW1

<400>	186
Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr 
            20                  25                  30  


<210>	187
<211>	14
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0643  VH FW2

<400>	187
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                5                   10                  


<210>	188
<211>	32
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0643  VH FW3

<400>	188
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
                5                   10                  15      

Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>	189
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0643  VH FW4

<400>	189
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                5                   10      


<210>	190
<211>	324
<212>	DNA
<213>	Homo sapiens

<220>
<223>	Bbbt0643  VL

<400>	190
tcttctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc      60

acatgccaag gagacagcct cagaagctat tatgcaagct ggtaccagca gaagccagga     120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga     180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa     240

gatgaggctg actattactg taactcccgg gacagcagtg gtaaccatgt ggtattcggc     300

ggagggacca agctgaccgt ccta                                            324


<210>	191
<211>	108
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0643  VL

<400>	191
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
                5                   10                  15      

Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          

Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              

Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  

Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  

Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      

Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>	192
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0643  VL CDR1

<400>	192
Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
                5                   10      


<210>	193
<211>	7
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0643  VL CDR2

<400>	193
Gly Lys Asn Asn Arg Pro Ser 
                5           


<210>	194
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0643  VL CDR3

<400>	194
Asn Ser Arg Asp Ser Ser Gly Asn His Val Val 
                5                   10      


<210>	195
<211>	22
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0643  VL FW1

<400>	195
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
                5                   10                  15      

Thr Val Arg Ile Thr Cys 
            20          


<210>	196
<211>	15
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0643  VL FW2

<400>	196
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
                5                   10                  15  


<210>	197
<211>	32
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0643  VL FW3

<400>	197
Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser 
                5                   10                  15      

Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>	198
<211>	10
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0643  VL FW4

<400>	198
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                5                   10  

<210>	199
<211>	366
<212>	DNA
<213>	Homo sapiens

<220>
<223>	Bbbt0351

<400>	199
gaagttcaac tgcaggcgtc cggcggtggc ctggtgcagg ctggcggctc tctgcgtctg      60

tcctgtgctg ccagcggctt taaaatcact cactatacta tgggctggtt ccgccaggca     120

ccgggcaaag agcgtgaatt cgtgagccgc atcacctggg gcggtgacaa caccttttac     180

tccaactccg ttaagggtcg ttttactatc tctcgtgata acgctaaaaa caccgtttac     240

ctgcagatga acagcctgaa accagaggac actgctgact actattgtgc tgcaggttcc     300

gcctctacgg ctgacccact gcgcgtcgac tattggggca aaggcaccca ggtgaccgtt     360

tcttcc                                                                366


<210>	200
<211>	122
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0351

<400>	200
Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
                5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          

Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              

Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp Tyr Tyr Cys 
                85                  90                  95      

Ala Ala Gly Ser Ala Ser Thr Ala Asp Pro Leu Arg Val Asp Tyr Trp 
            100                 105                 110         

Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>	201
<211>	5
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0351

<400>	201
His Tyr Thr Met Gly 
                5   


<210>	202
<211>	17
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0351

<400>	202
Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val Lys 
                5                   10                  15      

Gly 
    


<210>	203
<211>	13
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0351

<400>	203
Gly Ser Ala Ser Thr Ala Asp Pro Leu Arg Val Asp Tyr 
                5                   10              


<210>	204
<211>	30
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0351

<400>	204
Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
                5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr 
            20                  25                  30  


<210>	205
<211>	14
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0351

<400>	205
Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser 
                5                   10                  


<210>	206
<211>	32
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0351

<400>	206
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
                5                   10                  15      

Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>	207
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0351

<400>	207
Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
                5                   10      

<210>	208
<211>	387
<212>	DNA
<213>	Homo sapiens

<220>
<223>	Bbbt0579

<400>	208
ggggtgcagc tggtgcagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc      60

tcctgtgcag cctctggatt caccttcagt agctatgcta tgcactgggt ccgccaggct     120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagcaa taaatactac     180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagatgat     300

attgtagtag taccagctgc taatgcgaac tactactact actacatgga cgtctggggc     360

caaggaacca cagtcaccgt ctcctca                                         387


<210>	209
<211>	129
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0579

<400>	209
Gly Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
                5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Asp Asp Ile Val Val Val Pro Ala Ala Asn Ala Asn Tyr Tyr 
            100                 105                 110         

Tyr Tyr Tyr Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             

Ser 
    


<210>	210
<211>	5
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0579

<400>	210
Ser Tyr Ala Met His 
                5   


<210>	211
<211>	17
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0579

<400>	211
Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
                5                   10                  15      

Gly 
    


<210>	212
<211>	20
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0579

<400>	212
Asp Asp Ile Val Val Val Pro Ala Ala Asn Ala Asn Tyr Tyr Tyr Tyr 
                5                   10                  15      

Tyr Met Asp Val 
            20  


<210>	213
<211>	30
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0579

<400>	213
Gly Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
                5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>	214
<211>	14
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0579

<400>	214
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
                5                   10                  


<210>	215
<211>	32
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0579

<400>	215
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
                5                   10                  15      

Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>	216
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0579

<400>	216
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                5                   10      


<210>	217
<211>	321
<212>	DNA
<213>	Homo sapiens

<220>
<223>	Bbbt0579

<400>	217
gacatccaga tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc      60

atcacttgcc gggccagtca gggcattaac aattatttag cctggtatca gcaaaaacca     120

gggagagccc ctaagctcct gatctacgct gcatccagtt tacaaagtgg ggtcccatca     180

aggttcagcg gcagtggatc tggcacagat ttcactctca ccatcagcag cctgcagcct     240

gaagattttg caacttatta ctgtctccaa gattccgatt atcccctcac tttcggcgga     300

gggaccaagc tggagatcaa a                                               321


<210>	218
<211>	107
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0579

<400>	218
Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
                5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Asn Asn Tyr 
            20                  25                  30          

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Ser Asp Tyr Pro Leu 
                85                  90                  95      

Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>	219
<211>	11
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0579

<400>	219
Arg Ala Ser Gln Gly Ile Asn Asn Tyr Leu Ala 
                5                   10      


<210>	220
<211>	7
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0579

<400>	220
Ala Ala Ser Ser Leu Gln Ser 
                5           


<210>	221
<211>	9
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0579

<400>	222
Leu Gln Asp Ser Asp Tyr Pro Leu Thr 
                5                   


<210>	222
<211>	23
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0579

<400>	222
Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
                5                   10                  15      

Asp Arg Val Thr Ile Thr Cys 
            20              


<210>	223
<211>	15
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0579

<400>	223
Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr 
                5                   10                  15  


<210>	224
<211>	32
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0579

<400>	224
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                5                   10                  15      

Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>	225
<211>	10
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0579

<400>	225
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
                5                   10  


<210>	226
<211>	128
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0671

<400>	227
Glu Val His Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala His Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Lys Asn Tyr Tyr Tyr Asp Thr Ser Ala Tyr Tyr Tyr Val Gly Ser 
            100                 105                 110         

Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125             


<210>	228
<211>	110
<212>	PRT
<213>	Homo sapiens

<220>
<223>	Bbbt0671

<400>	228
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
                5                   10                  15      

Ser Ile Thr Ile Ser Cys Thr Ala Thr Ser Ser Asn Val Gly Ala Tyr 
            20                  25                  30          

Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Val 
        35                  40                  45              

Leu Ile Tyr Arg Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  

Gln Ala Asp Glu Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Thr Asp 
                85                  90                  95      

Tyr Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 