SEQUENCE LISTING

<110>   PROQR THERAPEUTICS II B.V.

<120>   TARGETED RNA EDITING

<130>   P065300WO

<140>   PCT/EP2015/______
<141>   2015-12-17

<150>   GB-1422511.4
<151>   2014-12-17

<150>   GB-1512467.0
<151>   2014-07-16

<150>   GB-1512595.8
<151>   2015-07-17

<150>   GB-1521987.6
<151>   2015-12-14

<160>   43

<170>   SeqWin2010, version 1.0

<210>   1
<211>   31
<212>   Combined DNA/RNA
<213>   Artificial Sequence

<220>
<223>   DNA-RNA oligonucleotide construct 

<220>
<221>   misc_feature
<223>   /note="Combined DNA / RNA"

<400>   1
cgcgcgtttt cgcgcggcug aaccacugca c                                 31

<210>   2
<211>   31
<212>   Combined DNA/RNA
<213>   Artificial Sequence

<220>
<223>   DNA-RNA oligonucleotide construct

<220>
<221>   misc_feature
<223>   /note="Combined DNA / RNA"

<400>   2
cgcgcgtttt cgcgcggaga uacucacaau u                                 31

<210>   3
<211>   31
<212>   Combined DNA/RNA
<213>   DNA-RNA oligonucleotide construct

<220>
<221>   misc_feature
<223>   /note="Combined DNA / RNA"

<400>   3
cgcgcgtttt cgcgcgcguu gaccuccacu c                                 31

<210>   4
<211>   4440
<212>   DNA
<213>   Homo sapiens

<220>
<221>   misc_feature
<222>   1653
<223>   'n' is c or t

<400>   4
atgcagaggt cgcctctgga aaaggccagc gttgtctcca aacttttttt cagctggacc  60
agaccaattt tgaggaaagg atacagacag cgcctggaat tgtcagacat ataccaaatc  120
ccttctgttg attctgctga caatctatct gaaaaattgg aaagagaatg ggatagagag  180
ctggcttcaa agaaaaatcc taaactcatt aatgcccttc ggcgatgttt tttctggaga  240
tttatgttct atggaatctt tttatattta ggggaagtca ccaaagcagt acagcctctc  300
ttactgggaa gaatcatagc ttcctatgac ccggataaca aggaggaacg ctctatcgcg  360
atttatctag gcataggctt atgccttctc tttattgtga ggacactgct cctacaccca  420
gccatttttg gccttcatca cattggaatg cagatgagaa tagctatgtt tagtttgatt  480
tataagaaga ctttaaagct gtcaagccgt gttctagata aaataagtat tggacaactt  540
gttagtctcc tttccaacaa cctgaacaaa tttgatgaag gacttgcatt ggcacatttc  600
gtgtggatcg ctcctttgca agtggcactc ctcatggggc taatctggga gttgttacag  660
gcgtctgcct tctgtggact tggtttcctg atagtccttg ccctttttca ggctgggcta  720
gggagaatga tgatgaagta cagagatcag agagctggga agatcagtga aagacttgtg  780
attacctcag aaatgattga aaatatccaa tctgttaagg catactgctg ggaagaagca  840
atggaaaaaa tgattgaaaa cttaagacaa acagaactga aactgactcg gaaggcagcc  900
tatgtgagat acttcaatag ctcagccttc ttcttctcag ggttctttgt ggtgttttta  960
tctgtgcttc cctatgcact aatcaaagga atcatcctcc ggaaaatatt caccaccatc  1020
tcattctgca ttgttctgcg catggcggtc actcggcaat ttccctgggc tgtacaaaca  1080
tggtatgact ctcttggagc aataaacaaa atacaggatt tcttacaaaa gcaagaatat  1140
aagacattgg aatataactt aacgactaca gaagtagtga tggagaatgt aacagccttc  1200
tgggaggagg gatttgggga attatttgag aaagcaaaac aaaacaataa caatagaaaa  1260
acttctaatg gtgatgacag cctcttcttc agtaatttct cacttcttgg tactcctgtc  1320
ctgaaagata ttaatttcaa gatagaaaga ggacagttgt tggcggttgc tggatccact  1380
ggagcaggca agacttcact tctaatgatg attatgggag aactggagcc ttcagagggt  1440
aaaattaagc acagtggaag aatttcattc tgttctcagt tttcctggat tatgcctggc  1500
accattaaag aaaatatcat ctttggtgtt tcctatgatg aatatagata cagaagcgtc  1560
atcaaagcat gccaactaga agaggacatc tccaagtttg cagagaaaga caatatagtt  1620
cttggagaag gtggaatcac actgagtgga gancaacgag caagaatttc tttagcaaga  1680
gcagtataca aagatgctga tttgtattta ttagactctc cttttggata cctagatgtt  1740
ttaacagaaa aagaaatatt tgaaagctgt gtctgtaaac tgatggctaa caaaactagg  1800
attttggtca cttctaaaat ggaacattta aagaaagctg acaaaatatt aattttgcat  1860
gaaggtagca gctattttta tgggacattt tcagaactcc aaaatctaca gccagacttt  1920
agctcaaaac tcatgggatg tgattctttc gaccaattta gtgcagaaag aagaaattca  1980
atcctaactg agaccttaca ccgtttctca ttagaaggag atgctcctgt ctcctggaca  2040
gaaacaaaaa aacaatcttt taaacagact ggagagtttg gggaaaaaag gaagaattct  2100
attctcaatc caatcaactc tatacgaaaa ttttccattg tgcaaaagac tcccttacaa  2160
atgaatggca tcgaagagga ttctgatgag cctttagaga gaaggctgtc cttagtacca  2220
gattctgagc agggagaggc gatactgcct cgcatcagcg tgatcagcac tggccccacg  2280
cttcaggcac gaaggaggca gtctgtcctg aacctgatga cacactcagt taaccaaggt  2340
cagaacattc accgaaagac aacagcatcc acacgaaaag tgtcactggc ccctcaggca  2400
aacttgactg aactggatat atattcaaga aggttatctc aagaaactgg cttggaaata  2460
agtgaagaaa ttaacgaaga agacttaaag gagtgctttt ttgatgatat ggagagcata  2520
ccagcagtga ctacatggaa cacatacctt cgatatatta ctgtccacaa gagcttaatt  2580
tttgtgctaa tttggtgctt agtaattttt ctggcagagg tggctgcttc tttggttgtg  2640
ctgtggctcc ttggaaacac tcctcttcaa gacaaaggga atagtactca tagtagaaat  2700
aacagctatg cagtgattat caccagcacc agttcgtatt atgtgtttta catttacgtg  2760
ggagtagccg acactttgct tgctatggga ttcttcagag gtctaccact ggtgcatact  2820
ctaatcacag tgtcgaaaat tttacaccac aaaatgttac attctgttct tcaagcacct  2880
atgtcaaccc tcaacacgtt gaaagcaggt gggattctta atagattctc caaagatata  2940
gcaattttgg atgaccttct gcctcttacc atatttgact tcatccagtt gttattaatt  3000
gtgattggag ctatagcagt tgtcgcagtt ttacaaccct acatctttgt tgcaacagtg  3060
ccagtgatag tggcttttat tatgttgaga gcatatttcc tccaaacctc acagcaactc  3120
aaacaactgg aatctgaagg caggagtcca attttcactc atcttgttac aagcttaaaa  3180
ggactatgga cacttcgtgc cttcggacgg cagccttact ttgaaactct gttccacaaa  3240
gctctgaatt tacatactgc caactggttc ttgtacctgt caacactgcg ctggttccaa  3300
atgagaatag aaatgatttt tgtcatcttc ttcattgctg ttaccttcat ttccatttta  3360
acaacaggag aaggagaagg aagagttggt attatcctga ctttagccat gaatatcatg  3420
agtacattgc agtgggctgt aaactccagc atagatgtgg atagcttgat gcgatctgtg  3480
agccgagtct ttaagttcat tgacatgcca acagaaggta aacctaccaa gtcaaccaaa  3540
ccatacaaga atggccaact ctcgaaagtt atgattattg agaattcaca cgtgaagaaa  3600
gatgacatct ggccctcagg gggccaaatg actgtcaaag atctcacagc aaaatacaca  3660
gaaggtggaa atgccatatt agagaacatt tccttctcaa taagtcctgg ccagagggtg  3720
ggcctcttgg gaagaactgg atcagggaag agtactttgt tatcagcttt tttgagacta  3780
ctgaacactg aaggagaaat ccagatcgat ggtgtgtctt gggattcaat aactttgcaa  3840
cagtggagga aagcctttgg agtgatacca cagaaagtat ttattttttc tggaacattt  3900
agaaaaaact tggatcccta tgaacagtgg agtgatcaag aaatatggaa agttgcagat  3960
gaggttgggc tcagatctgt gatagaacag tttcctggga agcttgactt tgtccttgtg  4020
gatgggggct gtgtcctaag ccatggccac aagcagttga tgtgcttggc tagatctgtt  4080
ctcagtaagg cgaagatctt gctgcttgat gaacccagtg ctcatttgga tccagtaaca  4140
taccaaataa ttagaagaac tctaaaacaa gcatttgctg attgcacagt aattctctgt  4200
gaacacagga tagaagcaat gctggaatgc caacaatttt tggtcataga agagaacaaa  4260
gtgcggcagt acgattccat ccagaaactg ctgaacgaga ggagcctctt ccggcaagcc  4320
atcagcccct ccgacagggt gaagctcttt ccccaccgga actcaagcaa gtgcaagtct  4380
aagccccaga ttgctgctct gaaagaggag acagaagaag aggtgcaaga tacaaggctt  4440

<210>   5
<211>   16
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Recruiting portion

<400>   5
cgcgcgtttt cgcgcg                                                  16

<210>   6
<211>   35
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Recruiting portion

<220>
<221>   misc_feature
<222>   4, 32
<223>   'n' is a, c, g or u, to form a base pair

<400>   6
auanuauaac aauaugcuaa auguuguuau anuau                             35

<210>   7
<211>   27
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Recruiting portion

<400>   7
uauaacaaua ugcuaaaugu uguuaua                                      27

<210>   8
<211>   21
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Targeting portion

<220>
<221>   misc_feature
<222>   1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21
<223>   'n' is a, c, g or u

<400>   8
nnnnnnnnnn nnnnnnncnn n                                            21

<210>   9
<211>   15
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Homo sapiens

<400>   9
gcaacuagag gugag                                                   15

<210>   10
<211>   23
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   10
tgctaagtac agggacatct tgc                                          23

<210>   11
<211>   25
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   11
agactccact tgttctttta aggag                                        25

<210>   12
<211>   26
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   12
tgactgctaa gtacagggac atcttg                                       26

<210>   13
<211>   24
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   13
aggagatgtt ttcacactcc aggt                                         24

<210>   14
<211>   23
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   14
ctggccccag ttgtaatttg tga                                          23

<210>   15
<211>   24
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   15
ctgttcccag gcttgttcaa tagt                                         24

<210>   16
<211>   44
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   GFP oligonucleotide construct

<400>   16
guguuggcca uggaacauau aacaauaugc uaaauguugu uaua                   44

<210>   17
<211>   44
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   GFP oligonucleotide construct

<400>   17
uauaacaaua ugcuaaaugu uguuauagug uuggccaugg aaca                   44

<210>   18
<211>   44
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   GFP oligonucleotide construct

<400>   18
guguuggcca uggaacauau aacaauaugc uaaauguugu uaua                   44

<210>   19
<211>   52
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   GFP oligonucleotide construct

<400>   19
guguuggcca uggaacaaua guauaacaau augcuaaaug uuguuauagu au          52

<210>   20
<211>   58
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   GFP oligonucleotide construct

<400>   20
ggaauaguau aacaauaugc uaaauguugu uauaguaucc cguguuggcc auggaaca    58

<210>   21
<211>   58
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   GFP oligonucleotide construct

<400>   21
guguuggcca uggaacagga auaguauaac aauaugcuaa auguuguuau aguauccc    58

<210>   22
<211>   58
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   GFP oligonucleotide construct

<400>   22
ggaauaguau aacaauaugc uaaauguugu uauaguaucc cguguuggcc auggaaca    58

<210>   23
<211>   41
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Recruiting portion

<220>
<221>   misc_feature
<222>   7, 35
<223>   'n' is a, c, g or u to form a base pair

<400>   23
ggaauanuau aacaauaugc uaaauguugu uauanuaucc c                      41

<210>   24
<211>   45
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Recruiting portion

<220>
<221>   misc_feature
<222>   9, 37
<223>   'n' is a, c, g or u to form a base pair

<400>   24
guggaauanu auaacaauau gcuaaauguu guuauanuau cccac                  45

<210>   25
<211>   45
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Recruiting portion

<220>
<221>   misc_feature
<222>   5, 9, 37, 41
<223>   'n' is a, c, g or u to form base pairs

<400>   25
guggnauanu auaacaauau gcuaaauguu guuauanuau nccac                  45

<210>   26
<211>   20
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   26
gcctggcacc attaaagaaa                                              20

<210>   27
<211>   24
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   27
gcatctttgt atactgctct tgct                                         24

<210>   28
<211>   66
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   A1AT oligonucleotide

<400>   28
ggaauaguau aacaauaugc uaaauguugu uauaguaucc ccagucccuu ucucgucgau  60
ggucag                                                             66

<210>   29
<211>   15
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Probe

<400>   29
ccatcgacga gaaag                                                   15

<210>   30
<211>   14
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Probe

<400>   30
catcgacaag aaag                                                    14

<210>   31
<211>   18
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   31
tccaggccgt gcataagg                                                18

<210>   32
<211>   16
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   32
gccccagcag cttcag                                                  16

<210>   33
<211>   161
<212>   DNA
<213>   Homo sapiens

<400>   33
atacctccac tcagccatga ttatataccg agacctgaaa ccccacaatg tgctgctttt  60
cacactgtat cccaatgctg ccatcattgc aaagattgct gactacggca ttgctcagta  120
ctgctgtaga atggggataa aaacatcaga gggcacacca g                      161

<210>   34
<211>   21
<212>   DNA
<213>   Homo sapiens

<400>   34
gctgactaca gcattgctca g                                            21

<210>   35
<211>   7
<212>   PRT
<213>   Homo sapiens

<400>   35
Ala Asp Tyr Ser Ile Ala Gln 
1               5           

<210>   36
<211>   21
<212>   DNA
<213>   Homo sapiens

<400>   36
gctgactacg gcattgctca g                                            21

<210>   37
<211>   7
<212>   PRT
<213>   Homo sapiens

<400>   37
Ala Asp Tyr Gly Ile Ala Gln 
1               5           

<210>   38
<211>   70
<212>   RNA
<213>   LRRK2 oligonucleotide construct

<400>   38
guggaauagu auaacaauau gcuaaauguu guuauaguau cccacacuga gcaaugccgu  60
agucagcaau                                                         70

<210>   39
<211>   75
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   LRRK2 oligonucleotide construct

<400>   39
guggaauagu auaacaauau gcuaaauguu guuauaguau cccacguacu gagcaaugcc  60
guagucagca aucuu                                                   75

<210>   40
<211>   66
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   LRRK2 oligonucleotide construct

<400>   40
ggaauaguau aacaauaugc uaaauguugu uauaguaucc cacugagcaa ugccguaguc  60
agcaau                                                             66

<210>   41
<211>   71
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   LRRK2 oligonucleotide construct

<400>   41
ggaauaguau aacaauaugc uaaauguugu uauaguaucc cguacugagc aaugccguag  60
ucagcaaucu u                                                       71

<210>   42
<211>   22
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   42
gtttgagata cctccactca gc                                           22

<210>   43
<211>   20
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   43
aggtgcacga aaccctggtg                                              20

