<110>  Novo Nordisk A/S

<120>  GLP-1 derivatives and uses thereof

<130>  140100WO01

<160>  9

<170>  Novo Nordisk A/S PatSeq 1.0.5.5

<210>  1
<211>  31
<212>  PRT
<213>  Homo sapiens
<220>  
<223>  Native human GLP-1

<400>  1
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
  1               5                  10                  15
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly
             20                  25                  30

<210>  2
<211>  31
<212>  PRT
<213>  Artificial Sequence
<220>  
<223>  GLP-1 analogue

<220>  
<221>  Mod_Res
<222>  (2)..(2)
<223>  /mod_res= "Aib (2-Aminoisobutyric acid)"

<400>  2
His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu
  1               5                  10                  15
Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys
             20                  25                  30

<210>  3
<211>  33
<212>  PRT
<213>  Artificial Sequence
<220>  
<223>  GLP-1 analogue

<220>  
<221>  Mod_Res
<222>  (1)..(1)
<223>  /mod_res= "Imp (3-(Imidazol-5-yl)propanoic acid)"

<220>  
<221>  Mod_Res
<222>  (2)..(2)
<223>  /mod_res= "Aib (2-Aminoisobutyric acid)"

<400>  3
Xaa Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu
  1               5                  10                  15
Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly
             20                  25                  30
Lys


<210>  4
<211>  31
<212>  PRT
<213>  Artificial Sequence
<220>  
<223>  GLP-1 analogue

<220>  
<221>  Mod_Res
<222>  (2)..(2)
<223>  /mod_res= "Aib (2-Aminoisobutyric acid)"

<220>  
<221>  Mod_Res
<222>  (16)..(16)
<223>  /mod_res= "Aib (2-Aminoisobutyric acid)"

<220>  
<221>  Mod_Res
<222>  (29)..(29)
<223>  /mod_res= "Aib (2-Aminoisobutyric acid)"

<220>  
<221>  Mod_Res
<222>  (31)..(31)
<223>  /mod_res= "Amidation"

<400>  4
His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Xaa
  1               5                  10                  15
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Xaa Arg Lys
             20                  25                  30

<210>  5
<211>  31
<212>  PRT
<213>  

<220>  
<221>  Mod_Res
<222>  (2)..(2)
<223>  /mod_res= "Aib (2-Aminoisobutyric acid)"

<400>  5
His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu
  1               5                  10                  15
Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly
             20                  25                  30

<210>  6
<211>  31
<212>  PRT
<213>  

<220>  
<221>  Mod_Res
<222>  (2)..(2)
<223>  /mod_res= "Aib (2-Aminoisobutyric acid)"

<400>  6
His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu
  1               5                  10                  15
Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Lys Arg Gly
             20                  25                  30

<210>  7
<211>  31
<212>  PRT
<213>  

<220>  
<221>  Mod_Res
<222>  (2)..(2)
<223>  /mod_res= "Aib (2-Aminoisobutyric acid)"

<400>  7
His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu
  1               5                  10                  15
Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly
             20                  25                  30

<210>  8
<211>  32
<212>  PRT
<213>  

<220>  
<221>  Mod_Res
<222>  (2)..(2)
<223>  /mod_res= "Aib (2-Aminoisobutyric acid)"

<400>  8
His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu
  1               5                  10                  15
Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Lys
             20                  25                  30

<210>  9
<211>  31
<212>  PRT
<213>  

<220>  
<221>  Mod_Res
<222>  (2)..(2)
<223>  /mod_res= "Aib (2-Aminoisobutyric acid)"

<400>  9
His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
  1               5                  10                  15
Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly
             20                  25                  30

