                         SEQUENCE LISTING

<110>  Roche Diagnostics GmbH
       F. Hoffmann-La Roche AG
 
<120>  IDENTIFICATION OF TRANSGLUTAMINASE SUBSTRATES AND USES THEREFOR

<130>  P32469-WO

<150>  US 62/094,495
<151>  2014-12-19

<160>  91    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  1

Asp Tyr Ala Leu Gln 
1               5   


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  2

Asp Tyr Val Leu Gln 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  3

Asn Tyr Ala Leu Gln 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  4

Glu Tyr Ala Leu Gln 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  5

Pro Tyr Ala Leu Gln 
1               5   


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  6

Glu Tyr Val Leu Gln 
1               5   


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  7

Asp Phe Ala Leu Gln 
1               5   


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  8

Asp Tyr Phe Leu Gln 
1               5   


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  9

Asn Tyr Phe Leu Gln 
1               5   


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  10

Phe Tyr Ala Leu Gln 
1               5   


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  11

Asp Tyr Thr Leu Gln 
1               5   


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  12

Asn Tyr Val Leu Gln 
1               5   


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  13

Glu Tyr Val Ala Gln 
1               5   


<210>  14
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  14

Arg Tyr Ala Leu Gln 
1               5   


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  15

Tyr Phe Ala Leu Gln 
1               5   


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  16

Pro Tyr Val Leu Gln 
1               5   


<210>  17
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  17

Trp Tyr Ala Leu Gln 
1               5   


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  18

Ser Tyr Ala Leu Gln 
1               5   


<210>  19
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  19

His Tyr Ala Leu Gln 
1               5   


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  20

Asp Tyr Val Ala Gln 
1               5   


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  21

Glu Phe Val Ala Gln 
1               5   


<210>  22
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  22

Asp Phe Tyr Leu Gln 
1               5   


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  23

Glu Phe Ala Leu Gln 
1               5   


<210>  24
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  24

Glu Tyr Phe Leu Gln 
1               5   


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  25

Asn Phe Val Leu Gln 
1               5   


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  26

Gly Gly Gly Asp Tyr Ala Leu Gln Gly Gly Gly 
1               5                   10      


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  27

Cys Gly Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   10      


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  28

Trp Gly Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   10      


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  29

Tyr Gly Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   10      


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  30

Asp Gly Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   10      


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  31

Gly Asp Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   10      


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  32

Asn Gly Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   10      


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  33

Gly Cys Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   10      


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  34

Glu Gly Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   10      


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  35

Pro Gly Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   10      


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  36

Thr Gly Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   10      


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  37

Gln Gly Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   10      


<210>  38
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  38

Ile Gly Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   10      


<210>  39
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  39

Phe Gly Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   10      


<210>  40
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  40

His Gly Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   10      


<210>  41
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  41

Leu Gly Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   10      


<210>  42
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  42

Val Gly Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   10      


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  43

Arg Gly Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   10      


<210>  44
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  44

Gly Trp Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   10      


<210>  45
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  45

Met Gly Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   10      


<210>  46
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  46

Ser Gly Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   10      


<210>  47
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  47

Ala Gly Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   10      


<210>  48
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  48

Gly Tyr Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   10      


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  49

Gly Glu Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   10      


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  50

Gly Pro Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   10      


<210>  51
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  51

Gly His Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   10      


<210>  52
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  52

Trp Asp Gly Asp Tyr Ala Leu Gln Gly Gly Gly 
1               5                   10      


<210>  53
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  53

Gly Asn Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   10      


<210>  54
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  54

Ala Arg Ser Lys Leu 
1               5   


<210>  55
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  55

Lys Ser Lys Leu Ala 
1               5   


<210>  56
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  56

Thr Lys Ser Lys Leu 
1               5   


<210>  57
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  57

Lys Leu Ser Lys Leu 
1               5   


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  58

Arg Ser Lys Leu Gly 
1               5   


<210>  59
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  59

Arg Gly Ser Lys Leu 
1               5   


<210>  60
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  60

Arg Gly Thr Lys Leu 
1               5   


<210>  61
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  61

Phe Pro Lys Leu Lys 
1               5   


<210>  62
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  62

Arg Ser Lys Ser Lys 
1               5   


<210>  63
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  63

Ser Lys Ser Lys Leu 
1               5   


<210>  64
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  64

Phe Thr Lys Ser Lys 
1               5   


<210>  65
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  65

Lys Leu Lys Tyr Lys 
1               5   


<210>  66
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  66

Pro Lys Thr Lys Leu 
1               5   


<210>  67
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  67

Arg Leu Lys Ser Lys 
1               5   


<210>  68
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  68

Arg Ser Lys Leu Ala 
1               5   


<210>  69
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  69

Gly Arg Ser Lys Leu 
1               5   


<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  70

Arg Ala Lys Tyr Lys 
1               5   


<210>  71
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  71

Ser Lys Leu Ser Lys 
1               5   


<210>  72
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  72

Lys Leu Gly Ala Lys 
1               5   


<210>  73
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  73

Gln Arg Ser Lys Leu 
1               5   


<210>  74
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  74

Lys Thr Lys Tyr Lys 
1               5   


<210>  75
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  75

Leu Ser Lys Leu Lys 
1               5   


<210>  76
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  76

Asn Arg Thr Lys Leu 
1               5   


<210>  77
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  77

Gln Arg Thr Lys Leu 
1               5   


<210>  78
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  78

Gly Tyr Lys Leu Lys 
1               5   


<210>  79
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  79

Gly Asp Tyr Ala Leu Gln Gly Pro Gly 
1               5                   


<210>  80
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  80

Gly Gly Gly Ala Arg Ser Lys Leu Gly Gly Gly Gly 
1               5                   10          


<210>  81
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  81

Gly Gly Gly Asp Glu Lys Pro Asp Gly Gly Gly Gly 
1               5                   10          


<210>  82
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  82

Gly Gly Gly Arg Ser Lys Leu Ala Gly Gly Gly 
1               5                   10      


<210>  83
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  83

His His His His His His His His Gly Gly Gly Gly Asp Tyr Ala Leu 
1               5                   10                  15      


Gln Gly Gly Gly Gly 
            20      


<210>  84
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  84

His His His His His His His His 
1               5               


<210>  85
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  85

Gly Gly Gly Gly Asp Tyr Ala Leu Gln Gly Gly Gly Gly 
1               5                   10              


<210>  86
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence

<400>  86

Gly Gly Gly Asp Tyr Ala Leu Gln Gly Gly Gly Gly 
1               5                   10          


<210>  87
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(474)
<223>  Vitamin D binding protein

<220>
<221>  MISC_FEATURE
<222>  (479)..(486)
<223>  8X Histidine Tag

<220>
<221>  MISC_FEATURE
<222>  (486)..(499)
<223>  Transglutaminase substrate tag

<400>  87

Met Lys Arg Val Leu Val Leu Leu Leu Ala Val Ala Phe Gly His Ala 
1               5                   10                  15      


Leu Glu Arg Gly Arg Asp Tyr Glu Lys Asn Lys Val Cys Lys Glu Phe 
            20                  25                  30          


Ser His Leu Gly Lys Glu Asp Phe Thr Ser Leu Ser Leu Val Leu Tyr 
        35                  40                  45              


Ser Arg Lys Phe Pro Ser Gly Thr Phe Glu Gln Val Ser Gln Leu Val 
    50                  55                  60                  


Lys Glu Val Val Ser Leu Thr Glu Ala Cys Cys Ala Glu Gly Ala Asp 
65                  70                  75                  80  


Pro Asp Cys Tyr Asp Thr Arg Thr Ser Ala Leu Ser Ala Lys Ser Cys 
                85                  90                  95      


Glu Ser Asn Ser Pro Phe Pro Val His Pro Gly Thr Ala Glu Cys Cys 
            100                 105                 110         


Thr Lys Glu Gly Leu Glu Arg Lys Leu Cys Met Ala Ala Leu Lys His 
        115                 120                 125             


Gln Pro Gln Glu Phe Pro Thr Tyr Val Glu Pro Thr Asn Asp Glu Ile 
    130                 135                 140                 


Cys Glu Ala Phe Arg Lys Asp Pro Lys Glu Tyr Ala Asn Gln Phe Met 
145                 150                 155                 160 


Trp Glu Tyr Ser Thr Asn Tyr Gly Gln Ala Pro Leu Ser Leu Leu Val 
                165                 170                 175     


Ser Tyr Thr Lys Ser Tyr Leu Ser Met Val Gly Ser Cys Cys Thr Ser 
            180                 185                 190         


Ala Ser Pro Thr Val Cys Phe Leu Lys Glu Arg Leu Gln Leu Lys His 
        195                 200                 205             


Leu Ser Leu Leu Thr Thr Leu Ser Asn Arg Val Cys Ser Gln Tyr Ala 
    210                 215                 220                 


Ala Tyr Gly Glu Lys Lys Ser Arg Leu Ser Asn Leu Ile Lys Leu Ala 
225                 230                 235                 240 


Gln Lys Val Pro Thr Ala Asp Leu Glu Asp Val Leu Pro Leu Ala Glu 
                245                 250                 255     


Asp Ile Thr Asn Ile Leu Ser Lys Cys Cys Glu Ser Ala Ser Glu Asp 
            260                 265                 270         


Cys Met Ala Lys Glu Leu Pro Glu His Thr Val Lys Leu Cys Asp Asn 
        275                 280                 285             


Leu Ser Thr Lys Asn Ser Lys Phe Glu Asp Cys Cys Gln Glu Lys Thr 
    290                 295                 300                 


Ala Met Asp Val Phe Val Cys Thr Tyr Phe Met Pro Ala Ala Gln Leu 
305                 310                 315                 320 


Pro Glu Leu Pro Asp Val Glu Leu Pro Thr Asn Lys Asp Val Cys Asp 
                325                 330                 335     


Pro Gly Asn Thr Lys Val Met Asp Lys Tyr Thr Phe Glu Leu Ser Arg 
            340                 345                 350         


Arg Thr His Leu Pro Glu Val Phe Leu Ser Lys Val Leu Glu Pro Thr 
        355                 360                 365             


Leu Lys Ser Leu Gly Glu Cys Cys Asp Val Glu Asp Ser Thr Thr Cys 
    370                 375                 380                 


Phe Asn Ala Lys Gly Pro Leu Leu Lys Lys Glu Leu Ser Ser Phe Ile 
385                 390                 395                 400 


Asp Lys Gly Gln Glu Leu Cys Ala Asp Tyr Ser Glu Asn Thr Phe Thr 
                405                 410                 415     


Glu Tyr Lys Lys Lys Leu Ala Glu Arg Leu Lys Ala Lys Leu Pro Asp 
            420                 425                 430         


Ala Thr Pro Thr Glu Leu Ala Lys Leu Val Asn Lys Arg Ser Asp Phe 
        435                 440                 445             


Ala Ser Asn Cys Cys Ser Ile Asn Ser Pro Pro Leu Tyr Cys Asp Ser 
    450                 455                 460                 


Glu Ile Asp Ala Glu Leu Lys Asn Ile Leu Gly Gly Gly Ser His His 
465                 470                 475                 480 


His His His His His His Gly Gly Gly Gly Asp Tyr Ala Leu Gln Gly 
                485                 490                 495     


Gly Gly Gly 
            


<210>  88
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer sequence

<400>  88
cagacataat agctgacaga ctaacagact gttcc                                  35


<210>  89
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer sequence

<400>  89
gtgatctgga tccttatcac acctcgatgt ggtcgggcag gtccacgatc tttccaccgt       60

gatggtggtg atggtggtga tg                                                82


<210>  90
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer sequence

<400>  90
gtgatctgga tccttatcaa ccgcctcc                                          28


<210>  91
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(458)
<223>  Mature Vitamin D Binding Protein

<220>
<221>  MISC_FEATURE
<222>  (463)..(470)
<223>  8X Histidine Tag

<220>
<221>  MISC_FEATURE
<222>  (471)..(483)
<223>  Transglutaminase substrate tag

<400>  91

Leu Glu Arg Gly Arg Asp Tyr Glu Lys Asn Lys Val Cys Lys Glu Phe 
1               5                   10                  15      


Ser His Leu Gly Lys Glu Asp Phe Thr Ser Leu Ser Leu Val Leu Tyr 
            20                  25                  30          


Ser Arg Lys Phe Pro Ser Gly Thr Phe Glu Gln Val Ser Gln Leu Val 
        35                  40                  45              


Lys Glu Val Val Ser Leu Thr Glu Ala Cys Cys Ala Glu Gly Ala Asp 
    50                  55                  60                  


Pro Asp Cys Tyr Asp Thr Arg Thr Ser Ala Leu Ser Ala Lys Ser Cys 
65                  70                  75                  80  


Glu Ser Asn Ser Pro Phe Pro Val His Pro Gly Thr Ala Glu Cys Cys 
                85                  90                  95      


Thr Lys Glu Gly Leu Glu Arg Lys Leu Cys Met Ala Ala Leu Lys His 
            100                 105                 110         


Gln Pro Gln Glu Phe Pro Thr Tyr Val Glu Pro Thr Asn Asp Glu Ile 
        115                 120                 125             


Cys Glu Ala Phe Arg Lys Asp Pro Lys Glu Tyr Ala Asn Gln Phe Met 
    130                 135                 140                 


Trp Glu Tyr Ser Thr Asn Tyr Gly Gln Ala Pro Leu Ser Leu Leu Val 
145                 150                 155                 160 


Ser Tyr Thr Lys Ser Tyr Leu Ser Met Val Gly Ser Cys Cys Thr Ser 
                165                 170                 175     


Ala Ser Pro Thr Val Cys Phe Leu Lys Glu Arg Leu Gln Leu Lys His 
            180                 185                 190         


Leu Ser Leu Leu Thr Thr Leu Ser Asn Arg Val Cys Ser Gln Tyr Ala 
        195                 200                 205             


Ala Tyr Gly Glu Lys Lys Ser Arg Leu Ser Asn Leu Ile Lys Leu Ala 
    210                 215                 220                 


Gln Lys Val Pro Thr Ala Asp Leu Glu Asp Val Leu Pro Leu Ala Glu 
225                 230                 235                 240 


Asp Ile Thr Asn Ile Leu Ser Lys Cys Cys Glu Ser Ala Ser Glu Asp 
                245                 250                 255     


Cys Met Ala Lys Glu Leu Pro Glu His Thr Val Lys Leu Cys Asp Asn 
            260                 265                 270         


Leu Ser Thr Lys Asn Ser Lys Phe Glu Asp Cys Cys Gln Glu Lys Thr 
        275                 280                 285             


Ala Met Asp Val Phe Val Cys Thr Tyr Phe Met Pro Ala Ala Gln Leu 
    290                 295                 300                 


Pro Glu Leu Pro Asp Val Glu Leu Pro Thr Asn Lys Asp Val Cys Asp 
305                 310                 315                 320 


Pro Gly Asn Thr Lys Val Met Asp Lys Tyr Thr Phe Glu Leu Ser Arg 
                325                 330                 335     


Arg Thr His Leu Pro Glu Val Phe Leu Ser Lys Val Leu Glu Pro Thr 
            340                 345                 350         


Leu Lys Ser Leu Gly Glu Cys Cys Asp Val Glu Asp Ser Thr Thr Cys 
        355                 360                 365             


Phe Asn Ala Lys Gly Pro Leu Leu Lys Lys Glu Leu Ser Ser Phe Ile 
    370                 375                 380                 


Asp Lys Gly Gln Glu Leu Cys Ala Asp Tyr Ser Glu Asn Thr Phe Thr 
385                 390                 395                 400 


Glu Tyr Lys Lys Lys Leu Ala Glu Arg Leu Lys Ala Lys Leu Pro Asp 
                405                 410                 415     


Ala Thr Pro Thr Glu Leu Ala Lys Leu Val Asn Lys Arg Ser Asp Phe 
            420                 425                 430         


Ala Ser Asn Cys Cys Ser Ile Asn Ser Pro Pro Leu Tyr Cys Asp Ser 
        435                 440                 445             


Glu Ile Asp Ala Glu Leu Lys Asn Ile Leu Gly Gly Gly Ser His His 
    450                 455                 460                 


His His His His His His Gly Gly Gly Gly Asp Tyr Ala Leu Gln Gly 
465                 470                 475                 480 


Gly Gly Gly 
            


