                         SEQUENCE LISTING

<110>  THE SCHEPENS EYE RESEARCH INSTITUTE
       GLAXOSMITHKLINE INTELLECTUAL
 
<120>  GDNF INDUCTION FOR THE TREATMENT OF RETINAL DISORDERS

<130>  36770-550001WO

<150>  62/090,913
<151>  2014-12-12

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Phe Pro Leu Pro Ala Gly Lys Arg Pro Pro Glu Ala Pro 
            20                  25                  30          


Ala Glu Asp Arg Ser Leu Gly Arg Arg Arg Ala Pro Phe Ala Leu Ser 
        35                  40                  45              


Ser Asp Ser Asn Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp Val 
    50                  55                  60                  


Met Asp Phe Ile Gln Ala Thr Ile Lys Arg Leu Lys Arg Ser Pro Asp 
65                  70                  75                  80  


Lys Gln Met Ala Val Leu Pro Arg Arg Glu Arg Asn Arg Gln Ala Ala 
                85                  90                  95      


Ala Ala Asn Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg Gly Gln Arg 
            100                 105                 110         


Gly Lys Asn Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val Thr 
        115                 120                 125             


Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg Tyr 
    130                 135                 140                 


Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr Asp Lys Ile Leu 
145                 150                 155                 160 


Lys Asn Leu Ser Arg Asn Arg Arg Leu Val Ser Asp Lys Val Gly Gln 
                165                 170                 175     


Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu Ser Phe Leu Asp 
            180                 185                 190         


Asp Asn Leu Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg Cys 
        195                 200                 205             


Gly Cys Ile 
    210     


<210>  2
<211>  3810
<212>  DNA
<213>  Homo sapiens

<400>  2
ccgcctccag cgcgcccttg ctgccccgcg cgaccccagg attgcgaact cttgcccctg       60

acctgttggg cggggctccg cgctccagcc atcagcccgg atgggtctcc tggctgggac      120

ttggggcacc tggagttaat gtccaaccta gggtctgcgg agacccgatc cgaggtgccg      180

ccgccggacg ggactttaag atgaagttat gggatgtcgt ggctgtctgc ctggtgctgc      240

tccacaccgc gtccgccttc ccgctgcccg ccggtaagag gcctcccgag gcgcccgccg      300

aagaccgctc cctcggccgc cgccgcgcgc ccttcgcgct gagcagtgac tcaaatatgc      360

cagaggatta tcctgatcag ttcgatgatg tcatggattt tattcaagcc accattaaaa      420

gactgaaaag gtcaccagat aaacaaatgg cagtgcttcc tagaagagag cggaatcggc      480

aggctgcagc tgccaaccca gagaattcca gaggaaaagg tcggagaggc cagaggggca      540

aaaaccgggg ttgtgtctta actgcaatac atttaaatgt cactgacttg ggtctgggct      600

atgaaaccaa ggaggaactg atttttaggt actgcagcgg ctcttgcgat gcagctgaga      660

caacgtacga caaaatattg aaaaacttat ccagaaatag aaggctggtg agtgacaaag      720

tagggcaggc atgttgcaga cccatcgcct ttgatgatga cctgtcgttt ttagatgata      780

acctggttta ccatattcta agaaagcatt ccgctaaaag gtgtggatgt atctgactcc      840

ggctccagag actgctgtgt attgcattcc tgctacagtg caaagaaagg gaccaaggtt      900

cccaggaaat gtttgcccag aatggaagat gaggaccaag gaggcggagg aggaggaaga      960

agaagaggag gaggaggagg aggaggagga ggaggaggaa ggcagccatc atgggagcct     1020

ggtagaggga gatccagcta cagacaactg gacaggagag agagaaaaca gccctctgga     1080

ttctccagga tggcagccga tgtcactaga agctcagggc tgatgttcct ggttggctat     1140

tgccaccatt tcagctgata cagtccacca tcactgatta ccggcgcggt tgcggtggat     1200

gcacttgaac caaaccagtg tatctcctgt gatttgtttt catgtgtccg aagacaccag     1260

ggaaacagag atcctggtgt tgttccttgt tattacgttt tactgctgaa agtaagaggt     1320

ttatttttct gtcactcagt ggagacatac cctggaaagg agaggggaaa aaaaaagcaa     1380

agatacaaga gataatcacc tttgcatttg aaagttgagg cccgaggttt actacaacca     1440

gcatttttgc caacggttgg tgattgattt ccatcacggt gtgtggggtg ggaagaagtt     1500

ggctaggaac caaaaaggct gtgctcatga ttaaacacaa acctgaaggt atttccttta     1560

tgtccttgga aacaggaaac gagttgtggt tttcgccagc attcttgtag gagagaatcg     1620

gggaaggccc cgaactgccc ccgggcaggg agagcccctc aggcctgttg gtttacagag     1680

agacagatgt tacataacca gctccgttga tgcgtggtca ccagtgacca gagaagctac     1740

tcgatgcaat gcatctgttt cagatacaga aatatagaga agatatttat tgaaatttaa     1800

gttattgtta tttattaccg ttcactaatg aatttctctt ttttccctta tttattaaag     1860

tttcttttca aaggtgccaa agtatatgtg ctcgcaaaat gcaaagaaag gtgacaaaag     1920

gaaatttgaa ttgggaacaa gggtccatgc ttttcaaagt attaaaaagt tttttgccag     1980

gcaaaaatca cttactttac ctttttaaga aaatttgtca ttaattttcc ccagatttca     2040

gcatttttcc caatttttat ttgtggagca tctcaggcaa gccccctttc ctggagcagc     2100

gtgcagagac cactggcact tgactttatt tcttccttgc tccattgctg aacagaaatg     2160

tcgtgggctc cacttcctgt tgtctttaag ctcttagtcc cctccacgta tacctatctg     2220

tactatgcat aaccatatgt agaaaaggtt cagttccttt tagtaggtag tcctggattt     2280

aatgctgacc taaaagtaat gtcgacaatg ctgtcaggta gctgccgttc taccgactcc     2340

ctccatccct gcccacccac tgccctcccg agaatatgct ggctgcccag tgcagcccgg     2400

gagacacagg ggccttccag aggtagggtc taccaggtcc tgtacaaccc ctgggctgtc     2460

accgggggtc aacagctgct gctcctatat acccaaacac ctgacagctc cctggggagc     2520

agatggctga gaagggtgct gaggaagcca tattgggacc agccacagcc acacacatgg     2580

agcctcatac ttaggagcgt gctgccttta aatgaaggtg gtcggggcca gtgcagcggc     2640

tcacacccat aatcccaaca ctttggaaag ccaaggtggg aggatctctt gaacccagga     2700

gtttgagacc agcttgggca acatagggag accctgtctc tacagaaact ttaaaaatta     2760

ggcaggcatg atggtgcaca cctgtggtcc cagctactca agaggctgaa ggaggatcac     2820

ttgagtccag aaggtcgagg ctgcagtgag ctgtgatcat gccactgcac tccagcctaa     2880

gtgacagtgc ggtaccctgt ctcaaaaaaa aaaaaaaaaa aaaaaagagg ttggagcagg     2940

aggaagcata ggggcgggaa cagccacctc ctccatgccc tagattgtga atttatcggg     3000

cagccaacac atgtatgaca cactaggccc tgtattacag cttgttacgc atttcataaa     3060

agggattttc attaaggaga taatctatta ctacctacct tagtggctac tagtataaaa     3120

ctatgacaga tttagcaatt aaatgaaata ctggcctcca tcaaataatc atagtaacaa     3180

gaagcagcag ttaccagaca tctgatcccc ttcccccaaa atacccaaat tcttcatggt     3240

tctgcccttc tctgtccttt ctgctcccct tgctcgcctg ggaaatggag gaaaggcctt     3300

ccctctcaca ctgtcttggg atcttgctga gaattcagac tgctcgaaac agtgacaaac     3360

cccagccatc cagtcattcg tggagcacaa tttggatgtg gccccagggg catctgtccc     3420

attcagagaa ccttggcagt gcgatggcca ctgttcccag gcttcaacct cagtgacccc     3480

ccccaacaac tccccatgga gagtccctgc ccaaaaaagc tgtaggatcc aaggggtgtc     3540

aatagctcgt tcccggcatc acctacacac cacaagcagg ttttaatgga agcaagttgc     3600

tccaccaaat ccacaaaagg gtaaagtttg tgatttttct ttatcattgc gatcaccatc     3660

tgataccgta aggagtgcac ttgtttggaa gttctgactt ctctgatctg tcttggtcgt     3720

ttgtgttata aaaccaaagt tctctacaga ctttattttt gtacaatatc attttgtaac     3780

tttttacaaa taaaaactca tttctattgc                                      3810


<210>  3
<211>  4477
<212>  DNA
<213>  Mus musculus

<400>  3
ggcaaacact ctgttctcct ctctcggctg ttccgcgctt cttcttctcg gtgctgggaa       60

aacttctcgg tgcaggctgc ttgtcttctc gcccctgcct tctgtcctgc agaaaaccgg      120

gagggcagga cactcggagg aggaaggaca gccttcgaag gggacgagga aagcgccgag      180

gtagcctcca gcaggcagag cgccctccct cggagcgcca gacgctttta ccaagttgcg      240

attgccccct ggggctgctg tgagccgagc tcagcgcacg ttcctgtgga tctaccctgc      300

tagaaaacgc gagccccgcc gcggttcctg caagccccgt gaagaggctc tcggagtcac      360

ccactcgcac cccgcaccgg gctcccgcag ctccggtgcc ttttgcccgg atctccgtcc      420

ctcccccaca ctcaggccgc cgttgccgcc ggaccccctc ccctcccccc tcccggttcg      480

gcgcccccct actccccaat cccggccctc tggcccgggc tctccacggc cagcctgcgc      540

tcctggcgcc ctcatgtctt caagggactg ccagcgcggt ttgacgtggt gtctcgttcg      600

gatctccagg caagacctcg gcagcatcag acaggcccgc ctcgcactcg cagccaccgc      660

gccccgagga ggtgcagagt gaggcgaccg cctcggagcc acccgcagcg cccggggccc      720

cgtgctgctc cagcccagag cgagcgccgc gcgcgcagcc gtgccactcc tcagccaagg      780

caggggcggc tgctcagact tagtcttctt ggggtccagg aggccggtgt gcgaggtgtc      840

ggcagccttc gccctcctcg cggcggcggc ggcggcggct ggcacggtgg ccgccgcctc      900

ctgcgtgtcc tcgctgcccg gcgcgacccc tggattgcgt gctcttgctc ccgaccttct      960

gggcggggcc ccgcgctcct gcccgaggtc cggatgggtc tcctggatgg gattcgggcc     1020

acttggagtt aatgtccaac tgggggtcta cggagaccgg atccgaggtg ccgccgccgg     1080

acgggactct aagatgaagt tatgggatgt cgtggctgtc tgcctggtgt tgctccacac     1140

cgcgtctgcc ttcccgctgc ccgccggtaa gaggcttctc gaagcgcccg ctgaagacca     1200

ctccctcggc caccgccgcg tgcccttcgc gctgaccagt gactccaata tgcctgaaga     1260

ttatcctgac cagtttgatg acgtcatgga ttttattcaa gccaccatta aaagactgaa     1320

aaggtcacca gataaacaag cggcagcgct tcctcgaaga gagaggaatc ggcaggctgc     1380

agctgccagc ccagagaatt ccagagggaa aggtcgcaga ggccagaggg gcaaaaatcg     1440

ggggtgcgtt ttaactgcca tacacttaaa tgtcactgac ttgggtttgg gctatgaaac     1500

caaggaggaa ctgatctttc gatattgcag cggttcctgt gaatcggccg agacaatgta     1560

tgacaaaata ctaaaaaacc tgtctcggag tagaaggcta acaagtgaca aagtaggcca     1620

ggcatgttgc aggccggtcg ccttcgacga cgacctgtcg tttttagatg acaacctggt     1680

ttaccatatt ctaagaaagc attccgctaa acggtgtgga tgtatctgac cccggctcca     1740

gagactgctg tgtattgcat tcctgctaca gtgcgaagaa agggaccaag gttcccagga     1800

aatgtttgcc cagagtggaa gataaggacc aagatggcgg aggcagaggc agaagaagag     1860

aaaaagaagg aggaaggtag ccaccgtggg agcctggtgg aagaaggccc agctacagaa     1920

aactggatag gagtgagaac agccgtctga gcacttcagg gtggcagctg atgtcaccag     1980

aagctcaggg ctggtgtcct tacttagctg ttgccagtgt ttatctgata cagtccatgg     2040

tcaccgatgg cggtccgagt cgtggatgca tgcaaagaac caagccagtg tatctcctgt     2100

ggtttgtttt cacgtgtttg aagacgccag ggaaatgtga cgattccggt gtcacctctt     2160

gtcactacat tttactgctg aaaataagaa agatgtattt tcctgtcact caatggattc     2220

ataccctgga aaggaaaggg ggtggggagg acaaaggcag agacgataaa aagatgacaa     2280

cctttgaatt tgaaaaccgg ggcctgaggt ctattacatc cagcattttg ggggacgctt     2340

ggtggttgat tctggacaca gagtgtgggg gtatggagaa gttggctagg aacccaaaaa     2400

aggctgtcct catacttaga aacaaacctg gaggcatctc cttcgtgccc tcagaaacag     2460

gaagcaagtt gtggttttcg gcagcattct cataggagag ccaatgggga aagcccccag     2520

ctgccccggc cagggagacc ccggggcctg ttggtttaca aagacggatg ttacatacac     2580

agctccgttc atgcgtggtc accagtgacc acagaagctc ctcgatgcaa tgcatctgtt     2640

tcaaatacag agatatagag aagatattta ttgagatttt aagttattat tatttattac     2700

cattcactaa tgaatatctt ttttcttccc ttatttatta aagtctcttt tcaaaggtgc     2760

caaagtatat gtgctcacaa aatacaaagg tgacagagga aatattaaca ttgagaacaa     2820

gggtccattc tcttcagagt ataagagggt ttttgctagg caaaaaatca cttactttat     2880

aaggcagtcc ttcactaact gccacagatt tcagcatttc cctccccctc tttctgtgga     2940

caggatctcc tgtagcctag gctgaccttg aacttactgc ttggtcaagg acgaccttgg     3000

ccttctgatc ctctgacttc ctgtggtctt ggcatggcag acatcaatca caccgtatcc     3060

acaggactaa gtatagaatt cagggcttca tccatgccag gcaactgtag gtaccaactg     3120

ggttacaccc agcccctgct ttctatctgc taaaggaaag ggtcaggagg gccatctcag     3180

ctccaccccc tcactgggag taccagtggg actgccacct gtttgcatct cctcttctat     3240

ccatctgagc agcaaggccc cagctccact gcccattgag ttcaactctt tttccccctt     3300

catcatgggc aatatcataa ccacgcattc agaaggctga actgcccttg gaagccctga     3360

acatattgtc acctgaaagt gcaatgaagg cccctgacag gcagccaggg tttaacagcc     3420

ccctcacccc cccgggcagg tggtacctct tcctctatcc ttgcccacct gcttcgtccc     3480

tatggttaca cagacaggag aacatagggg aactgtgcag ggagaggcca tctgccttgt     3540

cctttgccag ggctcagttg tcacctgggc tcaacttttg ctaccccctc aaacccaatg     3600

gattccaagg agaaagatgg acaggaagag acatctgact ggccatagaa caaagaagag     3660

gccctccctc attgtttgga gggaagaagc agagggtggg aatggcaact ctccctgcac     3720

cccataatgt ccttgtctgg cagccaacaa acaggtcatg ccttgagtcc tatgttagag     3780

ccttgagtcc tatgttacag atttcataaa tggaattttt atgtagaagt taatgtatca     3840

ctccctttgt ggctgctatc ccccgccccc agagtaggac agatagatct aaaataataa     3900

atgaccaatt aattggcctc tctcgaatag tcatgtcaaa ttttcaaagt aaccaagagg     3960

taaaagttac taggtatcct ttccccttcc gtggccctaa agacccacgt ttcgcatggt     4020

tccacaccct ctgcaggact gggaagtgga gctacgtatg cgctgctctc tccgctcctc     4080

ctgctcaaaa ttgtgacaac ctcagctgcc cagcacattt cagatgtcgt tccagaccct     4140

ctgttcactc cagagaatcc tgaaagatgt ggtagctgat gctcccaggt ccagacacag     4200

cctctagctc ttgggggaat ccctggagaa ctcagcatct cgagcaggtt cgaatgggag     4260

caggctgccc cacccagtcc gcagcagggt aaagtttgcg acggttcttt actgttgtga     4320

tcagcatctg ccccagtaaa gagcacactt ctttggaagt tctgacctct ctgatgtctc     4380

ggtcgtttgt gttatacaac caaagttctc tacaaacttt atttttgtac aatatcattt     4440

tgtaactttt tacaaataaa agctcatttc tattgct                              4477


<210>  4
<211>  240
<212>  PRT
<213>  Mus musculus

<400>  4

Met Gly Phe Gly Pro Leu Gly Val Asn Val Gln Leu Gly Val Tyr Gly 
1               5                   10                  15      


Asp Arg Ile Arg Gly Ala Ala Ala Gly Arg Asp Ser Lys Met Lys Leu 
            20                  25                  30          


Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr Ala Ser Ala 
        35                  40                  45              


Phe Pro Leu Pro Ala Gly Lys Arg Leu Leu Glu Ala Pro Ala Glu Asp 
    50                  55                  60                  


His Ser Leu Gly His Arg Arg Val Pro Phe Ala Leu Thr Ser Asp Ser 
65                  70                  75                  80  


Asn Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp Val Met Asp Phe 
                85                  90                  95      


Ile Gln Ala Thr Ile Lys Arg Leu Lys Arg Ser Pro Asp Lys Gln Ala 
            100                 105                 110         


Ala Ala Leu Pro Arg Arg Glu Arg Asn Arg Gln Ala Ala Ala Ala Ser 
        115                 120                 125             


Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg Gly Gln Arg Gly Lys Asn 
    130                 135                 140                 


Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val Thr Asp Leu Gly 
145                 150                 155                 160 


Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg Tyr Cys Ser Gly 
                165                 170                 175     


Ser Cys Glu Ser Ala Glu Thr Met Tyr Asp Lys Ile Leu Lys Asn Leu 
            180                 185                 190         


Ser Arg Ser Arg Arg Leu Thr Ser Asp Lys Val Gly Gln Ala Cys Cys 
        195                 200                 205             


Arg Pro Val Ala Phe Asp Asp Asp Leu Ser Phe Leu Asp Asp Asn Leu 
    210                 215                 220                 


Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg Cys Gly Cys Ile 
225                 230                 235                 240 


<210>  5
<211>  700
<212>  DNA
<213>  Rattus norvegicus

<400>  5
ggtctacgga gaccggatcc gaggtgccgc cgccggacgg gactctaaga tgaagttatg       60

ggatgtcgtg gctgtctgcc tggtgttgct ccacaccgcg tctgccttcc cgctgcccgc      120

cggtaagagg cttctcgaag cgcccgccga agaccactcc ctcggccacc gccgcgtgcc      180

cttcgcgctg accagtgact ccaatatgcc cgaagattat cctgaccagt ttgatgacgt      240

catggatttt attcaagcca ccatcaaaag actgaaaagg tcaccagata aacaagcggc      300

ggcacttcct cgaagagaga ggaaccggca agctgcagct gccagcccag agaattccag      360

agggaaaggt cgcagaggcc agaggggcaa aaatcggggg tgcgtcttaa ctgcaataca      420

cttaaatgtc actgacttgg gtttgggcta cgaaaccaag gaggaactga tctttcgata      480

ttgtagcggt tcctgtgaag cggccgagac aatgtacgac aaaatactaa aaaatctgtc      540

tcgaagtaga aggctaacaa gtgacaaggt aggccaggca tgttgcaggc cggtcgcctt      600

cgacgacgac ctgtcgtttt tagacgacag cctggtttac catatcctaa gaaagcattc      660

cgctaaacgg tgtggatgta tctgaccctg gctccagaga                            700


<210>  6
<211>  211
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Phe Pro Leu Pro Ala Gly Lys Arg Leu Leu Glu Ala Pro 
            20                  25                  30          


Ala Glu Asp His Ser Leu Gly His Arg Arg Val Pro Phe Ala Leu Thr 
        35                  40                  45              


Ser Asp Ser Asn Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp Val 
    50                  55                  60                  


Met Asp Phe Ile Gln Ala Thr Ile Lys Arg Leu Lys Arg Ser Pro Asp 
65                  70                  75                  80  


Lys Gln Ala Ala Ala Leu Pro Arg Arg Glu Arg Asn Arg Gln Ala Ala 
                85                  90                  95      


Ala Ala Ser Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg Gly Gln Arg 
            100                 105                 110         


Gly Lys Asn Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val Thr 
        115                 120                 125             


Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg Tyr 
    130                 135                 140                 


Cys Ser Gly Ser Cys Glu Ala Ala Glu Thr Met Tyr Asp Lys Ile Leu 
145                 150                 155                 160 


Lys Asn Leu Ser Arg Ser Arg Arg Leu Thr Ser Asp Lys Val Gly Gln 
                165                 170                 175     


Ala Cys Cys Arg Pro Val Ala Phe Asp Asp Asp Leu Ser Phe Leu Asp 
            180                 185                 190         


Asp Ser Leu Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg Cys 
        195                 200                 205             


Gly Cys Ile 
    210     


