                         SEQUENCE LISTING

<110>  New York University
 
<120>  CLOSTRIDIAL NEUROTOXIN FUSION PROTEINS, PROPEPTIDE FUSIONS, THEIR
        EXPRESSION, AND USE

<130>  29527.1653

<140>  PCT/US2015/064787
<141>  2015-12-09

<150>  62/089,646
<151>  2014-12-09

<150>  62/118,970
<151>  2015-02-20

<160>  71    

<170>  PatentIn version 3.5

<210>  1
<211>  4786
<212>  DNA
<213>  Artificial

<220>
<223>  Propeptide fusion encoding sequence

<400>  1
ggatcccggt ccgttcgaac cagaactctg gaagcttaac tcctaaaaaa ccgccaccat       60

gaaattctta gtcaacgttg cccttgtttt tatggtcgta tacatttctt acatctatgc      120

ggccggacac caccaccacc accaccacca ccaccaccac gacgtcgaaa acctgtactt      180

ccaaggcgca gaacaaaaac tcatcagcga ggaggacctg ggaggagggg cccacggtgg      240

tgctcaactg caactcgtcg agtccggtgg tggtatggtc caacctggtg gttctttgag      300

gctgtcatgt gcagcgagtg gattcacctt ctcgacttac gatatgtcct gggtgcgtca      360

agccccaggc aaaggccccg aatgggtctc tatcattaac gccggcggag gttcaaccta      420

ctacgctgcc agtgtcaagg gaaggttcgc tatctccaga gataacgcca aaaacaccct      480

ctacttgcag atgaacaatc tgaagcccga ggatactgct ctctactact gcgctcgcgt      540

ggccagctac tactgccgtg gctacgtctg ttctcctccc gagttcgact actggggaca      600

gggtacacaa gtgacggtct ccagcgaacc gaagactcca aaaccgcaag caggacaagg      660

tgctcccgtg ccctacccag acccattgga acccagagga acgcgtggag cgggagcagg      720

tccattcgtc aacaagcaat tcaactacaa agatcctgtt aacggtgtgg acatcgccta      780

catcaagatt ccgaacgcag gccagatgca acctgtgaag gctttcaaaa tccacaacaa      840

gatctgggtc attcccgaga gagacacatt cacgaaccca gaggaaggtg atctgaaccc      900

tcccccagaa gccaagcagg tgccggtctc ttactacgat tcaacctacc tcagtactga      960

caacgagaag gataactacc tgaagggcgt tactaaactc ttcgagcgca tctactcgac     1020

agacttgggc cgtatgctgc tcacgtccat cgtcaggggt attcctttct ggggtggctc     1080

aaccatcgac actgagctga aggtcattga tacaaactgc atcaacgtta ttcaacccga     1140

cggctcctac cgcagcgagg aattgaacct ggtgatcatt ggaccaagcg ccgacatcat     1200

ttacttcgag tgtaagtctt tcggccatga agtcctcaac ttgaccagaa acggctacgg     1260

ctccactcaa tacatccgct tcagccccga cttcacattc ggattcgagg aatcactgga     1320

ggtcgatacg aacccgttgc tgggtgctgg caagttcgcc accgaccctg cagttactct     1380

ggcacacgcg ctcatccacg cgggacatcg tctgtacggt atcgctatta acccaaacag     1440

ggtcttcaag gttaacacca acgcctacta cgagatgagt ggttacaggg tgtcgttcga     1500

ggaactccgt acgttcggag gtcacgacgc aaagttcatc gatagtttgc aggagaacga     1560

attccgcctg tactactaca acaagttcaa agacatcgcg tctacactca acaaggctaa     1620

aagcattgtt ggaaccactg ctagtttgca atacatgaag aacgtgttca aggagaaata     1680

cgagttgtcg gaagacacct ccggtaaatt cagcgtggac aagctgaaat tcgataagtt     1740

gtacaaaatg ctgacagaaa tctacacgga agacaacttc gttaagttct tcaaagtgtt     1800

gaaccgtaag accgctctga acttcgataa ggctgtcttc aaaatcaaca ttgtgcctaa     1860

agtcaactac accatctacg acggtttcaa cctccgcaac actaacttgg ctgccaactt     1920

caacggccag aacactgaga tcaacaacat gaacttcaca aagctcaaaa acttcaccgg     1980

tttgttcgag ttctacaagc tgctctgcgt gcgtggtatc attacatctc acacgcaatc     2040

tctagaccag ggtggcgaga acctgtactt ccagggtgct ctgaacgatc tgtgtatcaa     2100

ggtgaataac tgggatctgt tctttagccc aagcgaggat aacttcacga acgatctcaa     2160

caaaggtgaa gagatcacgt ctgataccaa tatcgaagcg gctgaagaga atatctcctt     2220

ggatctcatc cagcaatatt acctgacctt taacttcgat aacgagcccg aaaacatctc     2280

catcgagaac ctcagctcag acatcattgg tcagttggag ctgatgccaa acattgaacg     2340

cttccccaac ggcaagaaat acgaactcga caagtatacg atgtttcatt acttaagagc     2400

gcaggagttt gaacacggca agagccgcat tgctctcact aactccgtga atgaagccct     2460

gctcaatccg tcaagggtgt acacattctt tagctccgac tatgtcaaga aagtgaacaa     2520

agccaccgaa gcggcaatgt tcctgggatg ggttgaacaa ctggtctacg acttcaccga     2580

cgagacctct gaggtgagca caacggacaa gattgctgac atcactatca ttatcccgta     2640

tattggacct gccttgaata ttggcaacat gctctacaaa gacgatttcg ttggtgccct     2700

gatcttcagc ggtgccgtga tcctgttgga gttcattcct gaaatcgcca tccctgtgct     2760

gggcacgttc gctctggtct catacattgc gaataaggtc ttgaccgtgc agacaatcga     2820

taatgccctc tccaaacgta acgaaaaatg ggacgaggtc tacaaataca tcgtgaccaa     2880

ctggctggca aaggttaaca cccaaattga tctgatccgt aagaaaatga aggaggcttt     2940

ggagaaccag gctgaagcta ctaaagccat tatcaactac cagtataatc agtatacaga     3000

agaggaaaag aataacatca atttcaacat cgatgacttg tcctcaaagc tgaacgagtc     3060

catcaacaaa gctatgatca acatcaacaa attcctgaat cagtgctccg tgtcttacct     3120

gatgaactct atgatcccat acggtgtgaa gcgcctggag gacttcgatg ccagcctgaa     3180

agacgcactg ctcaaataca tttacgataa tcgcggcact ttgattggcc aagttgaccg     3240

tctgaaggac aaggttaaca ataccttgtc aaccgatatc cccttccaac tctctaagta     3300

cgtcgataac cagcgcttgc tgagcacctt cacagaatac atcaacaaca tcatcaacac     3360

ctccatcctg aacctccgtt acgagtctaa ccacctcatc gacttgagca gatacgctag     3420

caagatcaac atcggttcca aggtgaactt cgacccaatc gataagaacc agatccaact     3480

gttcaacctc gaatcctcta agatcgaagt gatcctgaag aacgctatcg tctacaactc     3540

catgtacgaa aacttctcta ccagcttctg gatcaggatt ccgaaatact tcaactcaat     3600

ctcgctcaac aacgagtaca ctatcatcaa ctgcatggaa aacaactcgg gatggaaggt     3660

gtccctcaac tacggcgaga tcatctggac tttgcaggac acacaagaaa tcaagcagag     3720

ggtcgtgttc aagtacagcc aaatgatcaa catcagcgat tacatcaacc gttggatctt     3780

cgtcacaatc accaacaacc gcctgaacaa ctccaagatt tacatcaacg gtagactgat     3840

cgaccagaag ccaatcagca acctcggcaa catccacgcc tcaaacaaca tcatgttcaa     3900

gttggacggc tgtagggata cacacagata catctggatc aaatacttca acctgttcga     3960

caaggagctc aacgagaagg aaatcaagga cctctacgat aaccagtcca actctggtat     4020

cttgaaggac ttctggggcg attacctgca atacgacaag ccctactaca tgttgaacct     4080

gtacgaccct aacaagtacg ttgatgtgaa caacgtcggt atcaggggct acatgtacct     4140

gaagggacca cgtggttctg ttatgaccac taacatctac ctcaacagct cattgtaccg     4200

tggcacaaag ttcatcatca agaagtacgc ctccggaaac aaggacaaca tcgtccgtaa     4260

caacgatcgc gtttacatca acgttgtggt caagaacaag gagtacagac tggctaccaa     4320

cgcttcgcag gctggagttg agaagatcct gtctgctctg gaaatccctg acgtgggcaa     4380

cctctcacag gttgtggtca tgaagtcgaa gaacgatcaa ggcatcacta acaagtgcaa     4440

gatgaacttg caggacaaca acggaaacga catcggcttc atcggattcc accaattcaa     4500

caacatcgcc aagttggtgg ccagcaactg gtacaaccgt cagatcgagc gttcgtcccg     4560

caccttagga tgctcgtggg agttcattcc agtcgatgac ggatggggag agagaccttt     4620

gggcgcagga ggagagaacc tgtacttcca gggtgcagga tggtcccacc cacaattcga     4680

gaagggtgca ggatggagtc acccacagtt cgagaagggc gctggatggt cccacccaca     4740

gttcgagaaa taattagttg atgcatagtt aattagatag ctcgag                    4786


<210>  2
<211>  1564
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein

<400>  2

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ala Gly His His His His His His His His His 
            20                  25                  30          


His His Asp Val Glu Asn Leu Tyr Phe Gln Gly Ala Glu Gln Lys Leu 
        35                  40                  45              


Ile Ser Glu Glu Asp Leu Gly Gly Gly Ala His Gly Gly Ala Gln Leu 
    50                  55                  60                  


Gln Leu Val Glu Ser Gly Gly Gly Met Val Gln Pro Gly Gly Ser Leu 
65                  70                  75                  80  


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr Asp Met 
                85                  90                  95      


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Ile 
            100                 105                 110         


Ile Asn Ala Gly Gly Gly Ser Thr Tyr Tyr Ala Ala Ser Val Lys Gly 
        115                 120                 125             


Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
    130                 135                 140                 


Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg 
145                 150                 155                 160 


Val Ala Ser Tyr Tyr Cys Arg Gly Tyr Val Cys Ser Pro Pro Glu Phe 
                165                 170                 175     


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys 
            180                 185                 190         


Thr Pro Lys Pro Gln Ala Gly Gln Gly Ala Pro Val Pro Tyr Pro Asp 
        195                 200                 205             


Pro Leu Glu Pro Arg Gly Thr Arg Gly Ala Gly Ala Gly Pro Phe Val 
    210                 215                 220                 


Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly Val Asp Ile Ala 
225                 230                 235                 240 


Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met Gln Pro Val Lys Ala Phe 
                245                 250                 255     


Lys Ile His Asn Lys Ile Trp Val Ile Pro Glu Arg Asp Thr Phe Thr 
            260                 265                 270         


Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu Ala Lys Gln Val 
        275                 280                 285             


Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr Asp Asn Glu Lys 
    290                 295                 300                 


Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu Phe Glu Arg Ile Tyr Ser 
305                 310                 315                 320 


Thr Asp Leu Gly Arg Met Leu Leu Thr Ser Ile Val Arg Gly Ile Pro 
                325                 330                 335     


Phe Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys Val Ile Asp Thr 
            340                 345                 350         


Asn Cys Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr Arg Ser Glu Glu 
        355                 360                 365             


Leu Asn Leu Val Ile Ile Gly Pro Ser Ala Asp Ile Ile Tyr Phe Glu 
    370                 375                 380                 


Cys Lys Ser Phe Gly His Glu Val Leu Asn Leu Thr Arg Asn Gly Tyr 
385                 390                 395                 400 


Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro Asp Phe Thr Phe Gly Phe 
                405                 410                 415     


Glu Glu Ser Leu Glu Val Asp Thr Asn Pro Leu Leu Gly Ala Gly Lys 
            420                 425                 430         


Phe Ala Thr Asp Pro Ala Val Thr Leu Ala His Ala Leu Ile His Ala 
        435                 440                 445             


Gly His Arg Leu Tyr Gly Ile Ala Ile Asn Pro Asn Arg Val Phe Lys 
    450                 455                 460                 


Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser Gly Tyr Arg Val Ser Phe 
465                 470                 475                 480 


Glu Glu Leu Arg Thr Phe Gly Gly His Asp Ala Lys Phe Ile Asp Ser 
                485                 490                 495     


Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn Lys Phe Lys Asp 
            500                 505                 510         


Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser Ile Val Gly Thr Thr Ala 
        515                 520                 525             


Ser Leu Gln Tyr Met Lys Asn Val Phe Lys Glu Lys Tyr Glu Leu Ser 
    530                 535                 540                 


Glu Asp Thr Ser Gly Lys Phe Ser Val Asp Lys Leu Lys Phe Asp Lys 
545                 550                 555                 560 


Leu Tyr Lys Met Leu Thr Glu Ile Tyr Thr Glu Asp Asn Phe Val Lys 
                565                 570                 575     


Phe Phe Lys Val Leu Asn Arg Lys Thr Ala Leu Asn Phe Asp Lys Ala 
            580                 585                 590         


Val Phe Lys Ile Asn Ile Val Pro Lys Val Asn Tyr Thr Ile Tyr Asp 
        595                 600                 605             


Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn Phe Asn Gly Gln 
    610                 615                 620                 


Asn Thr Glu Ile Asn Asn Met Asn Phe Thr Lys Leu Lys Asn Phe Thr 
625                 630                 635                 640 


Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys Val Arg Gly Ile Ile Thr 
                645                 650                 655     


Ser His Thr Gln Ser Leu Asp Gln Gly Gly Glu Asn Leu Tyr Phe Gln 
            660                 665                 670         


Gly Ala Leu Asn Asp Leu Cys Ile Lys Val Asn Asn Trp Asp Leu Phe 
        675                 680                 685             


Phe Ser Pro Ser Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu 
    690                 695                 700                 


Glu Ile Thr Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser 
705                 710                 715                 720 


Leu Asp Leu Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu 
                725                 730                 735     


Pro Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln 
            740                 745                 750         


Leu Glu Leu Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr 
        755                 760                 765             


Glu Leu Asp Lys Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe 
    770                 775                 780                 


Glu His Gly Lys Ser Arg Ile Ala Leu Thr Asn Ser Val Asn Glu Ala 
785                 790                 795                 800 


Leu Leu Asn Pro Ser Arg Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val 
                805                 810                 815     


Lys Lys Val Asn Lys Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val 
            820                 825                 830         


Glu Gln Leu Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr 
        835                 840                 845             


Thr Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro 
    850                 855                 860                 


Ala Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala 
865                 870                 875                 880 


Leu Ile Phe Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile 
                885                 890                 895     


Ala Ile Pro Val Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn 
            900                 905                 910         


Lys Val Leu Thr Val Gln Thr Ile Asp Asn Ala Leu Ser Lys Arg Asn 
        915                 920                 925             


Glu Lys Trp Asp Glu Val Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala 
    930                 935                 940                 


Lys Val Asn Thr Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala 
945                 950                 955                 960 


Leu Glu Asn Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr 
                965                 970                 975     


Asn Gln Tyr Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp 
            980                 985                 990         


Asp Leu Ser Ser Lys Leu Asn Glu  Ser Ile Asn Lys Ala  Met Ile Asn 
        995                 1000                 1005             


Ile Asn  Lys Phe Leu Asn Gln  Cys Ser Val Ser Tyr  Leu Met Asn 
    1010                 1015                 1020             


Ser Met  Ile Pro Tyr Gly Val  Lys Arg Leu Glu Asp  Phe Asp Ala 
    1025                 1030                 1035             


Ser Leu  Lys Asp Ala Leu Leu  Lys Tyr Ile Tyr Asp  Asn Arg Gly 
    1040                 1045                 1050             


Thr Leu  Ile Gly Gln Val Asp  Arg Leu Lys Asp Lys  Val Asn Asn 
    1055                 1060                 1065             


Thr Leu  Ser Thr Asp Ile Pro  Phe Gln Leu Ser Lys  Tyr Val Asp 
    1070                 1075                 1080             


Asn Gln  Arg Leu Leu Ser Thr  Phe Thr Glu Tyr Ile  Asn Asn Ile 
    1085                 1090                 1095             


Ile Asn  Thr Ser Ile Leu Asn  Leu Arg Tyr Glu Ser  Asn His Leu 
    1100                 1105                 1110             


Ile Asp  Leu Ser Arg Tyr Ala  Ser Lys Ile Asn Ile  Gly Ser Lys 
    1115                 1120                 1125             


Val Asn  Phe Asp Pro Ile Asp  Lys Asn Gln Ile Gln  Leu Phe Asn 
    1130                 1135                 1140             


Leu Glu  Ser Ser Lys Ile Glu  Val Ile Leu Lys Asn  Ala Ile Val 
    1145                 1150                 1155             


Tyr Asn  Ser Met Tyr Glu Asn  Phe Ser Thr Ser Phe  Trp Ile Arg 
    1160                 1165                 1170             


Ile Pro  Lys Tyr Phe Asn Ser  Ile Ser Leu Asn Asn  Glu Tyr Thr 
    1175                 1180                 1185             


Ile Ile  Asn Cys Met Glu Asn  Asn Ser Gly Trp Lys  Val Ser Leu 
    1190                 1195                 1200             


Asn Tyr  Gly Glu Ile Ile Trp  Thr Leu Gln Asp Thr  Gln Glu Ile 
    1205                 1210                 1215             


Lys Gln  Arg Val Val Phe Lys  Tyr Ser Gln Met Ile  Asn Ile Ser 
    1220                 1225                 1230             


Asp Tyr  Ile Asn Arg Trp Ile  Phe Val Thr Ile Thr  Asn Asn Arg 
    1235                 1240                 1245             


Leu Asn  Asn Ser Lys Ile Tyr  Ile Asn Gly Arg Leu  Ile Asp Gln 
    1250                 1255                 1260             


Lys Pro  Ile Ser Asn Leu Gly  Asn Ile His Ala Ser  Asn Asn Ile 
    1265                 1270                 1275             


Met Phe  Lys Leu Asp Gly Cys  Arg Asp Thr His Arg  Tyr Ile Trp 
    1280                 1285                 1290             


Ile Lys  Tyr Phe Asn Leu Phe  Asp Lys Glu Leu Asn  Glu Lys Glu 
    1295                 1300                 1305             


Ile Lys  Asp Leu Tyr Asp Asn  Gln Ser Asn Ser Gly  Ile Leu Lys 
    1310                 1315                 1320             


Asp Phe  Trp Gly Asp Tyr Leu  Gln Tyr Asp Lys Pro  Tyr Tyr Met 
    1325                 1330                 1335             


Leu Asn  Leu Tyr Asp Pro Asn  Lys Tyr Val Asp Val  Asn Asn Val 
    1340                 1345                 1350             


Gly Ile  Arg Gly Tyr Met Tyr  Leu Lys Gly Pro Arg  Gly Ser Val 
    1355                 1360                 1365             


Met Thr  Thr Asn Ile Tyr Leu  Asn Ser Ser Leu Tyr  Arg Gly Thr 
    1370                 1375                 1380             


Lys Phe  Ile Ile Lys Lys Tyr  Ala Ser Gly Asn Lys  Asp Asn Ile 
    1385                 1390                 1395             


Val Arg  Asn Asn Asp Arg Val  Tyr Ile Asn Val Val  Val Lys Asn 
    1400                 1405                 1410             


Lys Glu  Tyr Arg Leu Ala Thr  Asn Ala Ser Gln Ala  Gly Val Glu 
    1415                 1420                 1425             


Lys Ile  Leu Ser Ala Leu Glu  Ile Pro Asp Val Gly  Asn Leu Ser 
    1430                 1435                 1440             


Gln Val  Val Val Met Lys Ser  Lys Asn Asp Gln Gly  Ile Thr Asn 
    1445                 1450                 1455             


Lys Cys  Lys Met Asn Leu Gln  Asp Asn Asn Gly Asn  Asp Ile Gly 
    1460                 1465                 1470             


Phe Ile  Gly Phe His Gln Phe  Asn Asn Ile Ala Lys  Leu Val Ala 
    1475                 1480                 1485             


Ser Asn  Trp Tyr Asn Arg Gln  Ile Glu Arg Ser Ser  Arg Thr Leu 
    1490                 1495                 1500             


Gly Cys  Ser Trp Glu Phe Ile  Pro Val Asp Asp Gly  Trp Gly Glu 
    1505                 1510                 1515             


Arg Pro  Leu Gly Ala Gly Gly  Glu Asn Leu Tyr Phe  Gln Gly Ala 
    1520                 1525                 1530             


Gly Trp  Ser His Pro Gln Phe  Glu Lys Gly Ala Gly  Trp Ser His 
    1535                 1540                 1545             


Pro Gln  Phe Glu Lys Gly Ala  Gly Trp Ser His Pro  Gln Phe Glu 
    1550                 1555                 1560             


Lys 
    


<210>  3
<211>  4783
<212>  DNA
<213>  Artificial

<220>
<223>  Propeptide fusion encoding sequence

<400>  3
ggatcccggt ccgttcgaac cagaactctg gaagcttaac tcctaaaaaa ccgccaccat       60

gaaattctta gtcaacgttg cccttgtttt tatggtcgta tacatttctt acatctatgc      120

ggccggacac caccaccacc accaccacca ccaccaccac gacgtcgaaa acctgtactt      180

ccaaggtgca gagcagaaac tcatcagcga agaagatttg ggaggagggg cccacggtgc      240

tcaactccag ctcgttgagt ccggtggcgg aatggtgcaa cctggtggct ctttgaggct      300

gtcatgcgct gccagtggat tcaccttctc gacttacgac atgtcctggg tgcgtcaggc      360

acctggaaaa ggtcccgaat gggtcagcat cattaacgct ggaggtggca gcacatacta      420

cgcagcgtct gttaagggaa ggttcgctat ctccagagac aacgccaaaa acaccctcta      480

cttgcaaatg aacaacctga agcccgagga tactgctctc tactactgtg ctcgcgtcgc      540

ctcatactac tgccgtggct acgtttgtag tcctcccgag ttcgactact ggggccaggg      600

aacacaagtg acggtctcca gcgaaccaaa gacaccaaaa ccacaggctg gtcagggcgc      660

tcctgttcca tacccagatc cactggaacc aagaggaacg cgtggagcgg gagcaggtcc      720

attcgtcaac aagcaattca actacaaaga tcctgttaac ggtgtggaca tcgcctacat      780

caagattccg aacgcaggcc agatgcaacc tgtgaaggct ttcaaaatcc acaacaagat      840

ctgggtcatt cccgagagag acacattcac gaacccagag gaaggtgatc tgaaccctcc      900

cccagaagcc aagcaggtgc cggtctctta ctacgattca acctacctca gtactgacaa      960

cgagaaggat aactacctga agggcgttac taaactcttc gagcgcatct actcgacaga     1020

cttgggccgt atgctgctca cgtccatcgt caggggtatt cctttctggg gtggctcaac     1080

catcgacact gagctgaagg tcattgatac aaactgcatc aacgttattc aacccgacgg     1140

ctcctaccgc agcgaggaat tgaacctggt gatcattgga ccaagcgccg acatcattta     1200

cttcgagtgt aagtctttcg gccatgaagt cctcaacttg accagaaacg gctacggctc     1260

cactcaatac atccgcttca gccccgactt cacattcgga ttcgaggaat cactggaggt     1320

cgatacgaac ccgttgctgg gtgctggcaa gttcgccacc gaccctgcag ttactctggc     1380

acacgcgctc atccacgcgg gacatcgtct gtacggtatc gctattaacc caaacagggt     1440

cttcaaggtt aacaccaacg cctactacga gatgagtggt tacagggtgt cgttcgagga     1500

actccgtacg ttcggaggtc acgacgcaaa gttcatcgat agtttgcagg agaacgaatt     1560

ccgcctgtac tactacaaca agttcaaaga catcgcgtct acactcaaca aggctaaaag     1620

cattgttgga accactgcta gtttgcaata catgaagaac gtgttcaagg agaaatacga     1680

gttgtcggaa gacacctccg gtaaattcag cgtggacaag ctgaaattcg ataagttgta     1740

caaaatgctg acagaaatct acacggaaga caacttcgtt aagttcttca aagtgttgaa     1800

ccgtaagacc gctctgaact tcgataaggc tgtcttcaaa atcaacattg tgcctaaagt     1860

caactacacc atctacgacg gtttcaacct ccgcaacact aacttggctg ccaacttcaa     1920

cggccagaac actgagatca acaacatgaa cttcacaaag ctcaaaaact tcaccggttt     1980

gttcgagttc tacaagctgc tctgcgtgcg tggtggaggc acatctcaca cgcaatctga     2040

gaacctgtac ttccaaggtg gtggccaggg tggagctctg aacgatctgt gtatcaaggt     2100

gaataactgg gatctgttct ttagcccaag cgaggataac ttcacgaacg atctcaacaa     2160

aggtgaagag atcacgtctg ataccaatat cgaagcggct gaagagaata tctccttgga     2220

tctcatccag caatattacc tgacctttaa cttcgataac gagcccgaaa acatctccat     2280

cgagaacctc agctcagaca tcattggtca gttggagctg atgccaaaca ttgaacgctt     2340

ccccaacggc aagaaatacg aactcgacaa gtatacgatg tttcattact taagagcgca     2400

ggagtttgaa cacggcaaga gccgcattgc tctcactaac tccgtgaatg aagccctgct     2460

caatccgtca agggtgtaca cattctttag ctccgactat gtcaagaaag tgaacaaagc     2520

caccgaagcg gcaatgttcc tgggatgggt tgaacaactg gtctacgact tcaccgacga     2580

gacctctgag gtgagcacaa cggacaagat tgctgacatc actatcatta tcccgtatat     2640

tggacctgcc ttgaatattg gcaacatgct ctacaaagac gatttcgttg gtgccctgat     2700

cttcagcggt gccgtgatcc tgttggagtt cattcctgaa atcgccatcc ctgtgctggg     2760

cacgttcgct ctggtctcat acattgcgaa taaggtcttg accgtgcaga caatcgataa     2820

tgccctctcc aaacgtaacg aaaaatggga cgaggtctac aaatacatcg tgaccaactg     2880

gctggcaaag gttaacaccc aaattgatct gatccgtaag aaaatgaagg aggctttgga     2940

gaaccaggct gaagctacta aagccattat caactaccag tataatcagt atacagaaga     3000

ggaaaagaat aacatcaatt tcaacatcga tgacttgtcc tcaaagctga acgagtccat     3060

caacaaagct atgatcaaca tcaacaaatt cctgaatcag tgctccgtgt cttacctgat     3120

gaactctatg atcccatacg gtgtgaagcg cctggaggac ttcgatgcca gcctgaaaga     3180

cgcactgctc aaatacattt acgataatcg cggcactttg attggccaag ttgaccgtct     3240

gaaggacaag gttaacaata ccttgtcaac cgatatcccc ttccaactct ctaagtacgt     3300

cgataaccag cgcttgctga gcaccttcac agaatacatc aacaacatca tcaacacctc     3360

catcctgaac ctccgttacg agtctaacca cctcatcgac ttgagcagat acgctagcaa     3420

gatcaacatc ggttccaagg tgaacttcga cccaatcgat aagaaccaga tccaactgtt     3480

caacctcgaa tcctctaaga tcgaagtgat cctgaagaac gctatcgtct acaactccat     3540

gtacgaaaac ttctctacca gcttctggat caggattccg aaatacttca actcaatctc     3600

gctcaacaac gagtacacta tcatcaactg catggaaaac aactcgggat ggaaggtgtc     3660

cctcaactac ggcgagatca tctggacttt gcaggacaca caagaaatca agcagagggt     3720

cgtgttcaag tacagccaaa tgatcaacat cagcgattac atcaaccgtt ggatcttcgt     3780

cacaatcacc aacaaccgcc tgaacaactc caagatttac atcaacggta gactgatcga     3840

ccagaagcca atcagcaacc tcggcaacat ccacgcctca aacaacatca tgttcaagtt     3900

ggacggctgt agggatacac acagatacat ctggatcaaa tacttcaacc tgttcgacaa     3960

ggagctcaac gagaaggaaa tcaaggacct ctacgataac cagtccaact ctggtatctt     4020

gaaggacttc tggggcgatt acctgcaata cgacaagccc tactacatgt tgaacctgta     4080

cgaccctaac aagtacgttg atgtgaacaa cgtcggtatc aggggctaca tgtacctgaa     4140

gggaccacgt ggttctgtta tgaccactaa catctacctc aacagctcat tgtaccgtgg     4200

cacaaagttc atcatcaaga agtacgcctc cggaaacaag gacaacatcg tccgtaacaa     4260

cgatcgcgtt tacatcaacg ttgtggtcaa gaacaaggag tacagactgg ctaccaacgc     4320

ttcgcaggct ggagttgaga agatcctgtc tgctctggaa atccctgacg tgggcaacct     4380

ctcacaggtt gtggtcatga agtcgaagaa cgatcaaggc atcactaaca agtgcaagat     4440

gaacttgcag gacaacaacg gaaacgacat cggcttcatc ggattccacc aattcaacaa     4500

catcgccaag ttggtggcca gcaactggta caaccgtcag atcgagcgtt cgtcccgcac     4560

cttaggatgc tcgtgggagt tcattccagt cgatgacgga tggggagaga gacctttggg     4620

cgcaggagga gagaacctgt acttccaggg tgcaggatgg tcccacccac aattcgagaa     4680

gggtgcagga tggagtcacc cacagttcga gaagggcgct ggatggtccc acccacagtt     4740

cgagaaataa ttagttgatg catagttaat tagatagctc gag                       4783


<210>  4
<211>  1563
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein

<400>  4

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ala Gly His His His His His His His His His 
            20                  25                  30          


His His Asp Val Glu Asn Leu Tyr Phe Gln Gly Ala Glu Gln Lys Leu 
        35                  40                  45              


Ile Ser Glu Glu Asp Leu Gly Gly Gly Ala His Gly Ala Gln Leu Gln 
    50                  55                  60                  


Leu Val Glu Ser Gly Gly Gly Met Val Gln Pro Gly Gly Ser Leu Arg 
65                  70                  75                  80  


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr Asp Met Ser 
                85                  90                  95      


Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Ile Ile 
            100                 105                 110         


Asn Ala Gly Gly Gly Ser Thr Tyr Tyr Ala Ala Ser Val Lys Gly Arg 
        115                 120                 125             


Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met 
    130                 135                 140                 


Asn Asn Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg Val 
145                 150                 155                 160 


Ala Ser Tyr Tyr Cys Arg Gly Tyr Val Cys Ser Pro Pro Glu Phe Asp 
                165                 170                 175     


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr 
            180                 185                 190         


Pro Lys Pro Gln Ala Gly Gln Gly Ala Pro Val Pro Tyr Pro Asp Pro 
        195                 200                 205             


Leu Glu Pro Arg Gly Thr Arg Gly Ala Gly Ala Gly Pro Phe Val Asn 
    210                 215                 220                 


Lys Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly Val Asp Ile Ala Tyr 
225                 230                 235                 240 


Ile Lys Ile Pro Asn Ala Gly Gln Met Gln Pro Val Lys Ala Phe Lys 
                245                 250                 255     


Ile His Asn Lys Ile Trp Val Ile Pro Glu Arg Asp Thr Phe Thr Asn 
            260                 265                 270         


Pro Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu Ala Lys Gln Val Pro 
        275                 280                 285             


Val Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr Asp Asn Glu Lys Asp 
    290                 295                 300                 


Asn Tyr Leu Lys Gly Val Thr Lys Leu Phe Glu Arg Ile Tyr Ser Thr 
305                 310                 315                 320 


Asp Leu Gly Arg Met Leu Leu Thr Ser Ile Val Arg Gly Ile Pro Phe 
                325                 330                 335     


Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys Val Ile Asp Thr Asn 
            340                 345                 350         


Cys Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr Arg Ser Glu Glu Leu 
        355                 360                 365             


Asn Leu Val Ile Ile Gly Pro Ser Ala Asp Ile Ile Tyr Phe Glu Cys 
    370                 375                 380                 


Lys Ser Phe Gly His Glu Val Leu Asn Leu Thr Arg Asn Gly Tyr Gly 
385                 390                 395                 400 


Ser Thr Gln Tyr Ile Arg Phe Ser Pro Asp Phe Thr Phe Gly Phe Glu 
                405                 410                 415     


Glu Ser Leu Glu Val Asp Thr Asn Pro Leu Leu Gly Ala Gly Lys Phe 
            420                 425                 430         


Ala Thr Asp Pro Ala Val Thr Leu Ala His Ala Leu Ile His Ala Gly 
        435                 440                 445             


His Arg Leu Tyr Gly Ile Ala Ile Asn Pro Asn Arg Val Phe Lys Val 
    450                 455                 460                 


Asn Thr Asn Ala Tyr Tyr Glu Met Ser Gly Tyr Arg Val Ser Phe Glu 
465                 470                 475                 480 


Glu Leu Arg Thr Phe Gly Gly His Asp Ala Lys Phe Ile Asp Ser Leu 
                485                 490                 495     


Gln Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn Lys Phe Lys Asp Ile 
            500                 505                 510         


Ala Ser Thr Leu Asn Lys Ala Lys Ser Ile Val Gly Thr Thr Ala Ser 
        515                 520                 525             


Leu Gln Tyr Met Lys Asn Val Phe Lys Glu Lys Tyr Glu Leu Ser Glu 
    530                 535                 540                 


Asp Thr Ser Gly Lys Phe Ser Val Asp Lys Leu Lys Phe Asp Lys Leu 
545                 550                 555                 560 


Tyr Lys Met Leu Thr Glu Ile Tyr Thr Glu Asp Asn Phe Val Lys Phe 
                565                 570                 575     


Phe Lys Val Leu Asn Arg Lys Thr Ala Leu Asn Phe Asp Lys Ala Val 
            580                 585                 590         


Phe Lys Ile Asn Ile Val Pro Lys Val Asn Tyr Thr Ile Tyr Asp Gly 
        595                 600                 605             


Phe Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn Phe Asn Gly Gln Asn 
    610                 615                 620                 


Thr Glu Ile Asn Asn Met Asn Phe Thr Lys Leu Lys Asn Phe Thr Gly 
625                 630                 635                 640 


Leu Phe Glu Phe Tyr Lys Leu Leu Cys Val Arg Gly Gly Gly Thr Ser 
                645                 650                 655     


His Thr Gln Ser Glu Asn Leu Tyr Phe Gln Gly Gly Gly Gln Gly Gly 
            660                 665                 670         


Ala Leu Asn Asp Leu Cys Ile Lys Val Asn Asn Trp Asp Leu Phe Phe 
        675                 680                 685             


Ser Pro Ser Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu 
    690                 695                 700                 


Ile Thr Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu 
705                 710                 715                 720 


Asp Leu Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro 
                725                 730                 735     


Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu 
            740                 745                 750         


Glu Leu Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu 
        755                 760                 765             


Leu Asp Lys Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu 
    770                 775                 780                 


His Gly Lys Ser Arg Ile Ala Leu Thr Asn Ser Val Asn Glu Ala Leu 
785                 790                 795                 800 


Leu Asn Pro Ser Arg Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys 
                805                 810                 815     


Lys Val Asn Lys Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu 
            820                 825                 830         


Gln Leu Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr 
        835                 840                 845             


Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala 
    850                 855                 860                 


Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu 
865                 870                 875                 880 


Ile Phe Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala 
                885                 890                 895     


Ile Pro Val Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys 
            900                 905                 910         


Val Leu Thr Val Gln Thr Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu 
        915                 920                 925             


Lys Trp Asp Glu Val Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys 
    930                 935                 940                 


Val Asn Thr Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu 
945                 950                 955                 960 


Glu Asn Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn 
                965                 970                 975     


Gln Tyr Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp 
            980                 985                 990         


Leu Ser Ser Lys Leu Asn Glu Ser  Ile Asn Lys Ala Met  Ile Asn Ile 
        995                 1000                 1005             


Asn Lys  Phe Leu Asn Gln Cys  Ser Val Ser Tyr Leu  Met Asn Ser 
    1010                 1015                 1020             


Met Ile  Pro Tyr Gly Val Lys  Arg Leu Glu Asp Phe  Asp Ala Ser 
    1025                 1030                 1035             


Leu Lys  Asp Ala Leu Leu Lys  Tyr Ile Tyr Asp Asn  Arg Gly Thr 
    1040                 1045                 1050             


Leu Ile  Gly Gln Val Asp Arg  Leu Lys Asp Lys Val  Asn Asn Thr 
    1055                 1060                 1065             


Leu Ser  Thr Asp Ile Pro Phe  Gln Leu Ser Lys Tyr  Val Asp Asn 
    1070                 1075                 1080             


Gln Arg  Leu Leu Ser Thr Phe  Thr Glu Tyr Ile Asn  Asn Ile Ile 
    1085                 1090                 1095             


Asn Thr  Ser Ile Leu Asn Leu  Arg Tyr Glu Ser Asn  His Leu Ile 
    1100                 1105                 1110             


Asp Leu  Ser Arg Tyr Ala Ser  Lys Ile Asn Ile Gly  Ser Lys Val 
    1115                 1120                 1125             


Asn Phe  Asp Pro Ile Asp Lys  Asn Gln Ile Gln Leu  Phe Asn Leu 
    1130                 1135                 1140             


Glu Ser  Ser Lys Ile Glu Val  Ile Leu Lys Asn Ala  Ile Val Tyr 
    1145                 1150                 1155             


Asn Ser  Met Tyr Glu Asn Phe  Ser Thr Ser Phe Trp  Ile Arg Ile 
    1160                 1165                 1170             


Pro Lys  Tyr Phe Asn Ser Ile  Ser Leu Asn Asn Glu  Tyr Thr Ile 
    1175                 1180                 1185             


Ile Asn  Cys Met Glu Asn Asn  Ser Gly Trp Lys Val  Ser Leu Asn 
    1190                 1195                 1200             


Tyr Gly  Glu Ile Ile Trp Thr  Leu Gln Asp Thr Gln  Glu Ile Lys 
    1205                 1210                 1215             


Gln Arg  Val Val Phe Lys Tyr  Ser Gln Met Ile Asn  Ile Ser Asp 
    1220                 1225                 1230             


Tyr Ile  Asn Arg Trp Ile Phe  Val Thr Ile Thr Asn  Asn Arg Leu 
    1235                 1240                 1245             


Asn Asn  Ser Lys Ile Tyr Ile  Asn Gly Arg Leu Ile  Asp Gln Lys 
    1250                 1255                 1260             


Pro Ile  Ser Asn Leu Gly Asn  Ile His Ala Ser Asn  Asn Ile Met 
    1265                 1270                 1275             


Phe Lys  Leu Asp Gly Cys Arg  Asp Thr His Arg Tyr  Ile Trp Ile 
    1280                 1285                 1290             


Lys Tyr  Phe Asn Leu Phe Asp  Lys Glu Leu Asn Glu  Lys Glu Ile 
    1295                 1300                 1305             


Lys Asp  Leu Tyr Asp Asn Gln  Ser Asn Ser Gly Ile  Leu Lys Asp 
    1310                 1315                 1320             


Phe Trp  Gly Asp Tyr Leu Gln  Tyr Asp Lys Pro Tyr  Tyr Met Leu 
    1325                 1330                 1335             


Asn Leu  Tyr Asp Pro Asn Lys  Tyr Val Asp Val Asn  Asn Val Gly 
    1340                 1345                 1350             


Ile Arg  Gly Tyr Met Tyr Leu  Lys Gly Pro Arg Gly  Ser Val Met 
    1355                 1360                 1365             


Thr Thr  Asn Ile Tyr Leu Asn  Ser Ser Leu Tyr Arg  Gly Thr Lys 
    1370                 1375                 1380             


Phe Ile  Ile Lys Lys Tyr Ala  Ser Gly Asn Lys Asp  Asn Ile Val 
    1385                 1390                 1395             


Arg Asn  Asn Asp Arg Val Tyr  Ile Asn Val Val Val  Lys Asn Lys 
    1400                 1405                 1410             


Glu Tyr  Arg Leu Ala Thr Asn  Ala Ser Gln Ala Gly  Val Glu Lys 
    1415                 1420                 1425             


Ile Leu  Ser Ala Leu Glu Ile  Pro Asp Val Gly Asn  Leu Ser Gln 
    1430                 1435                 1440             


Val Val  Val Met Lys Ser Lys  Asn Asp Gln Gly Ile  Thr Asn Lys 
    1445                 1450                 1455             


Cys Lys  Met Asn Leu Gln Asp  Asn Asn Gly Asn Asp  Ile Gly Phe 
    1460                 1465                 1470             


Ile Gly  Phe His Gln Phe Asn  Asn Ile Ala Lys Leu  Val Ala Ser 
    1475                 1480                 1485             


Asn Trp  Tyr Asn Arg Gln Ile  Glu Arg Ser Ser Arg  Thr Leu Gly 
    1490                 1495                 1500             


Cys Ser  Trp Glu Phe Ile Pro  Val Asp Asp Gly Trp  Gly Glu Arg 
    1505                 1510                 1515             


Pro Leu  Gly Ala Gly Gly Glu  Asn Leu Tyr Phe Gln  Gly Ala Gly 
    1520                 1525                 1530             


Trp Ser  His Pro Gln Phe Glu  Lys Gly Ala Gly Trp  Ser His Pro 
    1535                 1540                 1545             


Gln Phe  Glu Lys Gly Ala Gly  Trp Ser His Pro Gln  Phe Glu Lys 
    1550                 1555                 1560             


<210>  5
<211>  4921
<212>  DNA
<213>  Artificial

<220>
<223>  Propeptide fusion encoding sequence

<400>  5
ggatcccggt ccgttcgaac cagaactctg gaagcttaac tcctaaaaaa ccgccaccat       60

gaaattctta gtcaacgttg cccttgtttt tatggtcgta tacatttctt acatctatgc      120

ggccggacac caccaccacc accaccacca ccaccaccac gacgtcgaaa acctgtactt      180

ccaaggcgca gaacaaaaac tcatcagcga ggaggacctg aaggcgtggc agcagcaatc      240

ttacctggac gagggtatcc acgaaggcgc taccactacc gccccttccg gtttcgcaaa      300

cgagttggga ccgaggctga tgggcaaggg aggaggggcc cacggtggtg ctcaactgca      360

actcgtcgag tccggtggtg gtatggtcca acctggtggt tctttgaggc tgtcatgtgc      420

agcgagtgga ttcaccttct cgacttacga tatgtcctgg gtgcgtcaag ccccaggcaa      480

aggccccgaa tgggtctcta tcattaacgc cggcggaggt tcaacctact acgctgccag      540

tgtcaaggga aggttcgcta tctccagaga taacgccaaa aacaccctct acttgcagat      600

gaacaatctg aagcccgagg atactgctct ctactactgc gctcgcgtgg ccagctacta      660

ctgccgtggc tacgtctgtt ctcctcccga gttcgactac tggggacagg gtacacaagt      720

gacggtctcc agcgaaccga agactccaaa accgcaagca ggacaaggtg ctcccgtgcc      780

ctacccagac ccattggaac ccagaggaac gcgtggagcg ggagcaggtc cattcgtcaa      840

caagcaattc aactacaaag atcctgttaa cggtgtggac atcgcctaca tcaagattcc      900

gaacgcaggc cagatgcaac ctgtgaaggc tttcaaaatc cacaacaaga tctgggtcat      960

tcccgagaga gacacattca cgaacccaga ggaaggtgat ctgaaccctc ccccagaagc     1020

caagcaggtg ccggtctctt actacgattc aacctacctc agtactgaca acgagaagga     1080

taactacctg aagggcgtta ctaaactctt cgagcgcatc tactcgacag acttgggccg     1140

tatgctgctc acgtccatcg tcaggggtat tcctttctgg ggtggctcaa ccatcgacac     1200

tgagctgaag gtcattgata caaactgcat caacgttatt caacccgacg gctcctaccg     1260

cagcgaggaa ttgaacctgg tgatcattgg accaagcgcc gacatcattt acttcgagtg     1320

taagtctttc ggccatgaag tcctcaactt gaccagaaac ggctacggct ccactcaata     1380

catccgcttc agccccgact tcacattcgg attcgaggaa tcactggagg tcgatacgaa     1440

cccgttgctg ggtgctggca agttcgccac cgaccctgca gttactctgg cacacgcgct     1500

catccacgcg ggacatcgtc tgtacggtat cgctattaac ccaaacaggg tcttcaaggt     1560

taacaccaac gcctactacg agatgagtgg ttacagggtg tcgttcgagg aactccgtac     1620

gttcggaggt cacgacgcaa agttcatcga tagtttgcag gagaacgaat tccgcctgta     1680

ctactacaac aagttcaaag acatcgcgtc tacactcaac aaggctaaaa gcattgttgg     1740

aaccactgct agtttgcaat acatgaagaa cgtgttcaag gagaaatacg agttgtcgga     1800

agacacctcc ggtaaattca gcgtggacaa gctgaaattc gataagttgt acaaaatgct     1860

gacagaaatc tacacggaag acaacttcgt taagttcttc aaagtgttga accgtaagac     1920

cgctctgaac ttcgataagg ctgtcttcaa aatcaacatt gtgcctaaag tcaactacac     1980

catctacgac ggtttcaacc tccgcaacac taacttggct gccaacttca acggccagaa     2040

cactgagatc aacaacatga acttcacaaa gctcaaaaac ttcaccggtt tgttcgagtt     2100

ctacaagctg ctctgcgtgc gtggtatcat tacatctcac acgcaatctc tagaccaggg     2160

tggcgagaac ctgtacttcc agggtgctct gaacgatctg tgtatcaagg tgaataactg     2220

ggatctgttc tttagcccaa gcgaggataa cttcacgaac gatctcaaca aaggtgaaga     2280

gatcacgtct gataccaata tcgaagcggc tgaagagaat atctccttgg atctcatcca     2340

gcaatattac ctgaccttta acttcgataa cgagcccgaa aacatctcca tcgagaacct     2400

cagctcagac atcattggtc agttggagct gatgccaaac attgaacgct tccccaacgg     2460

caagaaatac gaactcgaca agtatacgat gtttcattac ttaagagcgc aggagtttga     2520

acacggcaag agccgcattg ctctcactaa ctccgtgaat gaagccctgc tcaatccgtc     2580

aagggtgtac acattcttta gctccgacta tgtcaagaaa gtgaacaaag ccaccgaagc     2640

ggcaatgttc ctgggatggg ttgaacaact ggtctacgac ttcaccgacg agacctctga     2700

ggtgagcaca acggacaaga ttgctgacat cactatcatt atcccgtata ttggacctgc     2760

cttgaatatt ggcaacatgc tctacaaaga cgatttcgtt ggtgccctga tcttcagcgg     2820

tgccgtgatc ctgttggagt tcattcctga aatcgccatc cctgtgctgg gcacgttcgc     2880

tctggtctca tacattgcga ataaggtctt gaccgtgcag acaatcgata atgccctctc     2940

caaacgtaac gaaaaatggg acgaggtcta caaatacatc gtgaccaact ggctggcaaa     3000

ggttaacacc caaattgatc tgatccgtaa gaaaatgaag gaggctttgg agaaccaggc     3060

tgaagctact aaagccatta tcaactacca gtataatcag tatacagaag aggaaaagaa     3120

taacatcaat ttcaacatcg atgacttgtc ctcaaagctg aacgagtcca tcaacaaagc     3180

tatgatcaac atcaacaaat tcctgaatca gtgctccgtg tcttacctga tgaactctat     3240

gatcccatac ggtgtgaagc gcctggagga cttcgatgcc agcctgaaag acgcactgct     3300

caaatacatt tacgataatc gcggcacttt gattggccaa gttgaccgtc tgaaggacaa     3360

ggttaacaat accttgtcaa ccgatatccc cttccaactc tctaagtacg tcgataacca     3420

gcgcttgctg agcaccttca cagaatacat caacaacatc atcaacacct ccatcctgaa     3480

cctccgttac gagtctaacc acctcatcga cttgagcaga tacgctagca agatcaacat     3540

cggttccaag gtgaacttcg acccaatcga taagaaccag atccaactgt tcaacctcga     3600

atcctctaag atcgaagtga tcctgaagaa cgctatcgtc tacaactcca tgtacgaaaa     3660

cttctctacc agcttctgga tcaggattcc gaaatacttc aactcaatct cgctcaacaa     3720

cgagtacact atcatcaact gcatggaaaa caactcggga tggaaggtgt ccctcaacta     3780

cggcgagatc atctggactt tgcaggacac acaagaaatc aagcagaggg tcgtgttcaa     3840

gtacagccaa atgatcaaca tcagcgatta catcaaccgt tggatcttcg tcacaatcac     3900

caacaaccgc ctgaacaact ccaagattta catcaacggt agactgatcg accagaagcc     3960

aatcagcaac ctcggcaaca tccacgcctc aaacaacatc atgttcaagt tggacggctg     4020

tagggataca cacagataca tctggatcaa atacttcaac ctgttcgaca aggagctcaa     4080

cgagaaggaa atcaaggacc tctacgataa ccagtccaac tctggtatct tgaaggactt     4140

ctggggcgat tacctgcaat acgacaagcc ctactacatg ttgaacctgt acgaccctaa     4200

caagtacgtt gatgtgaaca acgtcggtat caggggctac atgtacctga agggaccacg     4260

tggttctgtt atgaccacta acatctacct caacagctca ttgtaccgtg gcacaaagtt     4320

catcatcaag aagtacgcct ccggaaacaa ggacaacatc gtccgtaaca acgatcgcgt     4380

ttacatcaac gttgtggtca agaacaagga gtacagactg gctaccaacg cttcgcaggc     4440

tggagttgag aagatcctgt ctgctctgga aatccctgac gtgggcaacc tctcacaggt     4500

tgtggtcatg aagtcgaaga acgatcaagg catcactaac aagtgcaaga tgaacttgca     4560

ggacaacaac ggaaacgaca tcggcttcat cggattccac caattcaaca acatcgccaa     4620

gttggtggcc agcaactggt acaaccgtca gatcgagcgt tcgtcccgca ccttaggatg     4680

ctcgtgggag ttcattccag tcgatgacgg atggggagag agacctttgg gcgcaggata     4740

cccctacgat gtccctgact acgctggaga gaacctgtac ttccagggtg caggatggtc     4800

ccacccacaa ttcgagaagg gtgcaggatg gagtcaccca cagttcgaga agggcgctgg     4860

atggtcccac ccacagttcg agaaataatt agttgatgca tagttaatta gatagctcga     4920

g                                                                     4921


<210>  6
<211>  1609
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein

<400>  6

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ala Gly His His His His His His His His His 
            20                  25                  30          


His His Asp Val Glu Asn Leu Tyr Phe Gln Gly Ala Glu Gln Lys Leu 
        35                  40                  45              


Ile Ser Glu Glu Asp Leu Lys Ala Trp Gln Gln Gln Ser Tyr Leu Asp 
    50                  55                  60                  


Glu Gly Ile His Glu Gly Ala Thr Thr Thr Ala Pro Ser Gly Phe Ala 
65                  70                  75                  80  


Asn Glu Leu Gly Pro Arg Leu Met Gly Lys Gly Gly Gly Ala His Gly 
                85                  90                  95      


Gly Ala Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Met Val Gln Pro 
            100                 105                 110         


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
        115                 120                 125             


Thr Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu 
    130                 135                 140                 


Trp Val Ser Ile Ile Asn Ala Gly Gly Gly Ser Thr Tyr Tyr Ala Ala 
145                 150                 155                 160 


Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr 
                165                 170                 175     


Leu Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
            180                 185                 190         


Tyr Cys Ala Arg Val Ala Ser Tyr Tyr Cys Arg Gly Tyr Val Cys Ser 
        195                 200                 205             


Pro Pro Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
    210                 215                 220                 


Ser Glu Pro Lys Thr Pro Lys Pro Gln Ala Gly Gln Gly Ala Pro Val 
225                 230                 235                 240 


Pro Tyr Pro Asp Pro Leu Glu Pro Arg Gly Thr Arg Gly Ala Gly Ala 
                245                 250                 255     


Gly Pro Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly 
            260                 265                 270         


Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met Gln Pro 
        275                 280                 285             


Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro Glu Arg 
    290                 295                 300                 


Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu 
305                 310                 315                 320 


Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr 
                325                 330                 335     


Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu Phe Glu 
            340                 345                 350         


Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr Ser Ile Val 
        355                 360                 365             


Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys 
    370                 375                 380                 


Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr 
385                 390                 395                 400 


Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala Asp Ile 
                405                 410                 415     


Ile Tyr Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn Leu Thr 
            420                 425                 430         


Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro Asp Phe 
        435                 440                 445             


Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro Leu Leu 
    450                 455                 460                 


Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala His Ala 
465                 470                 475                 480 


Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala Ile Asn Pro Asn 
                485                 490                 495     


Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser Gly Tyr 
            500                 505                 510         


Arg Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp Ala Lys 
        515                 520                 525             


Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn 
    530                 535                 540                 


Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser Ile Val 
545                 550                 555                 560 


Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys Glu Lys 
                565                 570                 575     


Tyr Glu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp Lys Leu 
            580                 585                 590         


Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr Thr Glu Asp 
        595                 600                 605             


Asn Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys Thr Ala Leu Asn 
    610                 615                 620                 


Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val Asn Tyr 
625                 630                 635                 640 


Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn 
                645                 650                 655     


Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr Lys Leu 
            660                 665                 670         


Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys Val Arg 
        675                 680                 685             


Gly Ile Ile Thr Ser His Thr Gln Ser Leu Asp Gln Gly Gly Glu Asn 
    690                 695                 700                 


Leu Tyr Phe Gln Gly Ala Leu Asn Asp Leu Cys Ile Lys Val Asn Asn 
705                 710                 715                 720 


Trp Asp Leu Phe Phe Ser Pro Ser Glu Asp Asn Phe Thr Asn Asp Leu 
                725                 730                 735     


Asn Lys Gly Glu Glu Ile Thr Ser Asp Thr Asn Ile Glu Ala Ala Glu 
            740                 745                 750         


Glu Asn Ile Ser Leu Asp Leu Ile Gln Gln Tyr Tyr Leu Thr Phe Asn 
        755                 760                 765             


Phe Asp Asn Glu Pro Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp 
    770                 775                 780                 


Ile Ile Gly Gln Leu Glu Leu Met Pro Asn Ile Glu Arg Phe Pro Asn 
785                 790                 795                 800 


Gly Lys Lys Tyr Glu Leu Asp Lys Tyr Thr Met Phe His Tyr Leu Arg 
                805                 810                 815     


Ala Gln Glu Phe Glu His Gly Lys Ser Arg Ile Ala Leu Thr Asn Ser 
            820                 825                 830         


Val Asn Glu Ala Leu Leu Asn Pro Ser Arg Val Tyr Thr Phe Phe Ser 
        835                 840                 845             


Ser Asp Tyr Val Lys Lys Val Asn Lys Ala Thr Glu Ala Ala Met Phe 
    850                 855                 860                 


Leu Gly Trp Val Glu Gln Leu Val Tyr Asp Phe Thr Asp Glu Thr Ser 
865                 870                 875                 880 


Glu Val Ser Thr Thr Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro 
                885                 890                 895     


Tyr Ile Gly Pro Ala Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp 
            900                 905                 910         


Phe Val Gly Ala Leu Ile Phe Ser Gly Ala Val Ile Leu Leu Glu Phe 
        915                 920                 925             


Ile Pro Glu Ile Ala Ile Pro Val Leu Gly Thr Phe Ala Leu Val Ser 
    930                 935                 940                 


Tyr Ile Ala Asn Lys Val Leu Thr Val Gln Thr Ile Asp Asn Ala Leu 
945                 950                 955                 960 


Ser Lys Arg Asn Glu Lys Trp Asp Glu Val Tyr Lys Tyr Ile Val Thr 
                965                 970                 975     


Asn Trp Leu Ala Lys Val Asn Thr Gln Ile Asp Leu Ile Arg Lys Lys 
            980                 985                 990         


Met Lys Glu Ala Leu Glu Asn Gln  Ala Glu Ala Thr Lys  Ala Ile Ile 
        995                 1000                 1005             


Asn Tyr  Gln Tyr Asn Gln Tyr  Thr Glu Glu Glu Lys  Asn Asn Ile 
    1010                 1015                 1020             


Asn Phe  Asn Ile Asp Asp Leu  Ser Ser Lys Leu Asn  Glu Ser Ile 
    1025                 1030                 1035             


Asn Lys  Ala Met Ile Asn Ile  Asn Lys Phe Leu Asn  Gln Cys Ser 
    1040                 1045                 1050             


Val Ser  Tyr Leu Met Asn Ser  Met Ile Pro Tyr Gly  Val Lys Arg 
    1055                 1060                 1065             


Leu Glu  Asp Phe Asp Ala Ser  Leu Lys Asp Ala Leu  Leu Lys Tyr 
    1070                 1075                 1080             


Ile Tyr  Asp Asn Arg Gly Thr  Leu Ile Gly Gln Val  Asp Arg Leu 
    1085                 1090                 1095             


Lys Asp  Lys Val Asn Asn Thr  Leu Ser Thr Asp Ile  Pro Phe Gln 
    1100                 1105                 1110             


Leu Ser  Lys Tyr Val Asp Asn  Gln Arg Leu Leu Ser  Thr Phe Thr 
    1115                 1120                 1125             


Glu Tyr  Ile Asn Asn Ile Ile  Asn Thr Ser Ile Leu  Asn Leu Arg 
    1130                 1135                 1140             


Tyr Glu  Ser Asn His Leu Ile  Asp Leu Ser Arg Tyr  Ala Ser Lys 
    1145                 1150                 1155             


Ile Asn  Ile Gly Ser Lys Val  Asn Phe Asp Pro Ile  Asp Lys Asn 
    1160                 1165                 1170             


Gln Ile  Gln Leu Phe Asn Leu  Glu Ser Ser Lys Ile  Glu Val Ile 
    1175                 1180                 1185             


Leu Lys  Asn Ala Ile Val Tyr  Asn Ser Met Tyr Glu  Asn Phe Ser 
    1190                 1195                 1200             


Thr Ser  Phe Trp Ile Arg Ile  Pro Lys Tyr Phe Asn  Ser Ile Ser 
    1205                 1210                 1215             


Leu Asn  Asn Glu Tyr Thr Ile  Ile Asn Cys Met Glu  Asn Asn Ser 
    1220                 1225                 1230             


Gly Trp  Lys Val Ser Leu Asn  Tyr Gly Glu Ile Ile  Trp Thr Leu 
    1235                 1240                 1245             


Gln Asp  Thr Gln Glu Ile Lys  Gln Arg Val Val Phe  Lys Tyr Ser 
    1250                 1255                 1260             


Gln Met  Ile Asn Ile Ser Asp  Tyr Ile Asn Arg Trp  Ile Phe Val 
    1265                 1270                 1275             


Thr Ile  Thr Asn Asn Arg Leu  Asn Asn Ser Lys Ile  Tyr Ile Asn 
    1280                 1285                 1290             


Gly Arg  Leu Ile Asp Gln Lys  Pro Ile Ser Asn Leu  Gly Asn Ile 
    1295                 1300                 1305             


His Ala  Ser Asn Asn Ile Met  Phe Lys Leu Asp Gly  Cys Arg Asp 
    1310                 1315                 1320             


Thr His  Arg Tyr Ile Trp Ile  Lys Tyr Phe Asn Leu  Phe Asp Lys 
    1325                 1330                 1335             


Glu Leu  Asn Glu Lys Glu Ile  Lys Asp Leu Tyr Asp  Asn Gln Ser 
    1340                 1345                 1350             


Asn Ser  Gly Ile Leu Lys Asp  Phe Trp Gly Asp Tyr  Leu Gln Tyr 
    1355                 1360                 1365             


Asp Lys  Pro Tyr Tyr Met Leu  Asn Leu Tyr Asp Pro  Asn Lys Tyr 
    1370                 1375                 1380             


Val Asp  Val Asn Asn Val Gly  Ile Arg Gly Tyr Met  Tyr Leu Lys 
    1385                 1390                 1395             


Gly Pro  Arg Gly Ser Val Met  Thr Thr Asn Ile Tyr  Leu Asn Ser 
    1400                 1405                 1410             


Ser Leu  Tyr Arg Gly Thr Lys  Phe Ile Ile Lys Lys  Tyr Ala Ser 
    1415                 1420                 1425             


Gly Asn  Lys Asp Asn Ile Val  Arg Asn Asn Asp Arg  Val Tyr Ile 
    1430                 1435                 1440             


Asn Val  Val Val Lys Asn Lys  Glu Tyr Arg Leu Ala  Thr Asn Ala 
    1445                 1450                 1455             


Ser Gln  Ala Gly Val Glu Lys  Ile Leu Ser Ala Leu  Glu Ile Pro 
    1460                 1465                 1470             


Asp Val  Gly Asn Leu Ser Gln  Val Val Val Met Lys  Ser Lys Asn 
    1475                 1480                 1485             


Asp Gln  Gly Ile Thr Asn Lys  Cys Lys Met Asn Leu  Gln Asp Asn 
    1490                 1495                 1500             


Asn Gly  Asn Asp Ile Gly Phe  Ile Gly Phe His Gln  Phe Asn Asn 
    1505                 1510                 1515             


Ile Ala  Lys Leu Val Ala Ser  Asn Trp Tyr Asn Arg  Gln Ile Glu 
    1520                 1525                 1530             


Arg Ser  Ser Arg Thr Leu Gly  Cys Ser Trp Glu Phe  Ile Pro Val 
    1535                 1540                 1545             


Asp Asp  Gly Trp Gly Glu Arg  Pro Leu Gly Ala Gly  Tyr Pro Tyr 
    1550                 1555                 1560             


Asp Val  Pro Asp Tyr Ala Gly  Glu Asn Leu Tyr Phe  Gln Gly Ala 
    1565                 1570                 1575             


Gly Trp  Ser His Pro Gln Phe  Glu Lys Gly Ala Gly  Trp Ser His 
    1580                 1585                 1590             


Pro Gln  Phe Glu Lys Gly Ala  Gly Trp Ser His Pro  Gln Phe Glu 
    1595                 1600                 1605             


Lys 
    


<210>  7
<211>  4921
<212>  DNA
<213>  Artificial

<220>
<223>  Propeptide fusion encoding sequence

<400>  7
ggatcccggt ccgttcgaac cagaactctg gaagcttaac tcctaaaaaa ccgccaccat       60

gaaattctta gtcaacgttg cccttgtttt tatggtcgta tacatttctt acatctatgc      120

ggccggacac caccaccacc accaccacca ccaccaccac gacgtcgaaa acctgtactt      180

ccaaggagcg gagcaaaaac tcattagcga ggaggacctg aaagcctggc aacaacaatc      240

atacctggac tccggtatcc acgaaggcgc taccactacc gccccttctg gtttcgctaa      300

cgaactgggt ccgagattga tgggaaaagg aggcggggcc cacggtggtg ctcaactcca      360

gctcgttgag tccggtggcg gaatggtgca acctggtggc tctttgaggc tgtcatgcgc      420

tgccagtgga ttcaccttct cgacttacga catgtcctgg gtgcgtcagg cacctggaaa      480

aggtcccgaa tgggtcagca tcattaacgc tggaggtggc agcacatact acgcagcgtc      540

tgttaaggga aggttcgcta tctccagaga caacgccaaa aacaccctct acttgcaaat      600

gaacaacctg aagcccgagg atactgctct ctactactgt gctcgcgtcg cctcatacta      660

ctgccgtggc tacgtttgta gtcctcccga gttcgactac tggggccagg gaacacaagt      720

gacggtctcc agcgaaccaa agacaccaaa accacaggct ggtcagggcg ctcctgttcc      780

atacccagat ccactggaac caagaggaac gcgtggagcg ggagcaggtc cattcgtcaa      840

caagcaattc aactacaaag atcctgttaa cggtgtggac atcgcctaca tcaagattcc      900

gaacgcaggc cagatgcaac ctgtgaaggc tttcaaaatc cacaacaaga tctgggtcat      960

tcccgagaga gacacattca cgaacccaga ggaaggtgat ctgaaccctc ccccagaagc     1020

caagcaggtg ccggtctctt actacgattc aacctacctc agtactgaca acgagaagga     1080

taactacctg aagggcgtta ctaaactctt cgagcgcatc tactcgacag acttgggccg     1140

tatgctgctc acgtccatcg tcaggggtat tcctttctgg ggtggctcaa ccatcgacac     1200

tgagctgaag gtcattgata caaactgcat caacgttatt caacccgacg gctcctaccg     1260

cagcgaggaa ttgaacctgg tgatcattgg accaagcgcc gacatcattt acttcgagtg     1320

taagtctttc ggccatgaag tcctcaactt gaccagaaac ggctacggct ccactcaata     1380

catccgcttc agccccgact tcacattcgg attcgaggaa tcactggagg tcgatacgaa     1440

cccgttgctg ggtgctggca agttcgccac cgaccctgca gttactctgg cacacgcgct     1500

catccacgcg ggacatcgtc tgtacggtat cgctattaac ccaaacaggg tcttcaaggt     1560

taacaccaac gcctactacg agatgagtgg ttacagggtg tcgttcgagg aactccgtac     1620

gttcggaggt cacgacgcaa agttcatcga tagtttgcag gagaacgaat tccgcctgta     1680

ctactacaac aagttcaaag acatcgcgtc tacactcaac aaggctaaaa gcattgttgg     1740

aaccactgct agtttgcaat acatgaagaa cgtgttcaag gagaaatacg agttgtcgga     1800

agacacctcc ggtaaattca gcgtggacaa gctgaaattc gataagttgt acaaaatgct     1860

gacagaaatc tacacggaag acaacttcgt taagttcttc aaagtgttga accgtaagac     1920

cgctctgaac ttcgataagg ctgtcttcaa aatcaacatt gtgcctaaag tcaactacac     1980

catctacgac ggtttcaacc tccgcaacac taacttggct gccaacttca acggccagaa     2040

cactgagatc aacaacatga acttcacaaa gctcaaaaac ttcaccggtt tgttcgagtt     2100

ctacaagctg ctctgcgtgc gtggtggagg cacatctcac acgcaatctg agaacctgta     2160

cttccaaggt ggtggccagg gtggagctct gaacgatctg tgtatcaagg tgaataactg     2220

ggatctgttc tttagcccaa gcgaggataa cttcacgaac gatctcaaca aaggtgaaga     2280

gatcacgtct gataccaata tcgaagcggc tgaagagaat atctccttgg atctcatcca     2340

gcaatattac ctgaccttta acttcgataa cgagcccgaa aacatctcca tcgagaacct     2400

cagctcagac atcattggtc agttggagct gatgccaaac attgaacgct tccccaacgg     2460

caagaaatac gaactcgaca agtatacgat gtttcattac ttaagagcgc aggagtttga     2520

acacggcaag agccgcattg ctctcactaa ctccgtgaat gaagccctgc tcaatccgtc     2580

aagggtgtac acattcttta gctccgacta tgtcaagaaa gtgaacaaag ccaccgaagc     2640

ggcaatgttc ctgggatggg ttgaacaact ggtctacgac ttcaccgacg agacctctga     2700

ggtgagcaca acggacaaga ttgctgacat cactatcatt atcccgtata ttggacctgc     2760

cttgaatatt ggcaacatgc tctacaaaga cgatttcgtt ggtgccctga tcttcagcgg     2820

tgccgtgatc ctgttggagt tcattcctga aatcgccatc cctgtgctgg gcacgttcgc     2880

tctggtctca tacattgcga ataaggtctt gaccgtgcag acaatcgata atgccctctc     2940

caaacgtaac gaaaaatggg acgaggtcta caaatacatc gtgaccaact ggctggcaaa     3000

ggttaacacc caaattgatc tgatccgtaa gaaaatgaag gaggctttgg agaaccaggc     3060

tgaagctact aaagccatta tcaactacca gtataatcag tatacagaag aggaaaagaa     3120

taacatcaat ttcaacatcg atgacttgtc ctcaaagctg aacgagtcca tcaacaaagc     3180

tatgatcaac atcaacaaat tcctgaatca gtgctccgtg tcttacctga tgaactctat     3240

gatcccatac ggtgtgaagc gcctggagga cttcgatgcc agcctgaaag acgcactgct     3300

caaatacatt tacgataatc gcggcacttt gattggccaa gttgaccgtc tgaaggacaa     3360

ggttaacaat accttgtcaa ccgatatccc cttccaactc tctaagtacg tcgataacca     3420

gcgcttgctg agcaccttca cagaatacat caacaacatc atcaacacct ccatcctgaa     3480

cctccgttac gagtctaacc acctcatcga cttgagcaga tacgctagca agatcaacat     3540

cggttccaag gtgaacttcg acccaatcga taagaaccag atccaactgt tcaacctcga     3600

atcctctaag atcgaagtga tcctgaagaa cgctatcgtc tacaactcca tgtacgaaaa     3660

cttctctacc agcttctgga tcaggattcc gaaatacttc aactcaatct cgctcaacaa     3720

cgagtacact atcatcaact gcatggaaaa caactcggga tggaaggtgt ccctcaacta     3780

cggcgagatc atctggactt tgcaggacac acaagaaatc aagcagaggg tcgtgttcaa     3840

gtacagccaa atgatcaaca tcagcgatta catcaaccgt tggatcttcg tcacaatcac     3900

caacaaccgc ctgaacaact ccaagattta catcaacggt agactgatcg accagaagcc     3960

aatcagcaac ctcggcaaca tccacgcctc aaacaacatc atgttcaagt tggacggctg     4020

tagggataca cacagataca tctggatcaa atacttcaac ctgttcgaca aggagctcaa     4080

cgagaaggaa atcaaggacc tctacgataa ccagtccaac tctggtatct tgaaggactt     4140

ctggggcgat tacctgcaat acgacaagcc ctactacatg ttgaacctgt acgaccctaa     4200

caagtacgtt gatgtgaaca acgtcggtat caggggctac atgtacctga agggaccacg     4260

tggttctgtt atgaccacta acatctacct caacagctca ttgtaccgtg gcacaaagtt     4320

catcatcaag aagtacgcct ccggaaacaa ggacaacatc gtccgtaaca acgatcgcgt     4380

ttacatcaac gttgtggtca agaacaagga gtacagactg gctaccaacg cttcgcaggc     4440

tggagttgag aagatcctgt ctgctctgga aatccctgac gtgggcaacc tctcacaggt     4500

tgtggtcatg aagtcgaaga acgatcaagg catcactaac aagtgcaaga tgaacttgca     4560

ggacaacaac ggaaacgaca tcggcttcat cggattccac caattcaaca acatcgccaa     4620

gttggtggcc agcaactggt acaaccgtca gatcgagcgt tcgtcccgca ccttaggatg     4680

ctcgtgggag ttcattccag tcgatgacgg atggggagag agacctttgg gcgcaggata     4740

cccctacgat gtccctgact acgctggaga gaacctgtac ttccagggtg caggatggtc     4800

ccacccacaa ttcgagaagg gtgcaggatg gagtcaccca cagttcgaga agggcgctgg     4860

atggtcccac ccacagttcg agaaataatt agttgatgca tagttaatta gatagctcga     4920

g                                                                     4921


<210>  8
<211>  1627
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein

<400>  8

Asp Pro Gly Pro Phe Glu Pro Glu Leu Trp Lys Leu Asn Ser Lys Thr 
1               5                   10                  15      


Ala Thr Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val 
            20                  25                  30          


Tyr Ile Ser Tyr Ile Tyr Ala Ala Gly His His His His His His His 
        35                  40                  45              


His His His His Asp Val Glu Asn Leu Tyr Phe Gln Gly Ala Glu Gln 
    50                  55                  60                  


Lys Leu Ile Ser Glu Glu Asp Leu Lys Ala Trp Gln Gln Gln Ser Tyr 
65                  70                  75                  80  


Leu Asp Ser Gly Ile His Glu Gly Ala Thr Thr Thr Ala Pro Ser Gly 
                85                  90                  95      


Phe Ala Asn Glu Leu Gly Pro Arg Leu Met Gly Lys Gly Gly Gly Ala 
            100                 105                 110         


His Gly Gly Ala Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Met Val 
        115                 120                 125             


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
    130                 135                 140                 


Phe Ser Thr Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
145                 150                 155                 160 


Pro Glu Trp Val Ser Ile Ile Asn Ala Gly Gly Gly Ser Thr Tyr Tyr 
                165                 170                 175     


Ala Ala Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys 
            180                 185                 190         


Asn Thr Leu Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala 
        195                 200                 205             


Leu Tyr Tyr Cys Ala Arg Val Ala Ser Tyr Tyr Cys Arg Gly Tyr Val 
    210                 215                 220                 


Cys Ser Pro Pro Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr 
225                 230                 235                 240 


Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Ala Gly Gln Gly Ala 
                245                 250                 255     


Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro Arg Gly Thr Arg Gly Ala 
            260                 265                 270         


Gly Ala Gly Pro Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val 
        275                 280                 285             


Asn Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met 
    290                 295                 300                 


Gln Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro 
305                 310                 315                 320 


Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro 
                325                 330                 335     


Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu 
            340                 345                 350         


Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu 
        355                 360                 365             


Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr Ser 
    370                 375                 380                 


Ile Val Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr Glu 
385                 390                 395                 400 


Leu Lys Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly 
                405                 410                 415     


Ser Tyr Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala 
            420                 425                 430         


Asp Ile Ile Tyr Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn 
        435                 440                 445             


Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro 
    450                 455                 460                 


Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro 
465                 470                 475                 480 


Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala 
                485                 490                 495     


His Ala Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala Ile Asn 
            500                 505                 510         


Pro Asn Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser 
        515                 520                 525             


Gly Tyr Arg Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp 
    530                 535                 540                 


Ala Lys Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr 
545                 550                 555                 560 


Tyr Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser 
                565                 570                 575     


Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys 
            580                 585                 590         


Glu Lys Tyr Glu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp 
        595                 600                 605             


Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr Thr 
    610                 615                 620                 


Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys Thr Ala 
625                 630                 635                 640 


Leu Asn Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val 
                645                 650                 655     


Asn Tyr Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala 
            660                 665                 670         


Ala Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr 
        675                 680                 685             


Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys 
    690                 695                 700                 


Val Arg Gly Gly Gly Thr Ser His Thr Gln Ser Glu Asn Leu Tyr Phe 
705                 710                 715                 720 


Gln Gly Gly Gly Gln Gly Gly Ala Leu Asn Asp Leu Cys Ile Lys Val 
                725                 730                 735     


Asn Asn Trp Asp Leu Phe Phe Ser Pro Ser Glu Asp Asn Phe Thr Asn 
            740                 745                 750         


Asp Leu Asn Lys Gly Glu Glu Ile Thr Ser Asp Thr Asn Ile Glu Ala 
        755                 760                 765             


Ala Glu Glu Asn Ile Ser Leu Asp Leu Ile Gln Gln Tyr Tyr Leu Thr 
    770                 775                 780                 


Phe Asn Phe Asp Asn Glu Pro Glu Asn Ile Ser Ile Glu Asn Leu Ser 
785                 790                 795                 800 


Ser Asp Ile Ile Gly Gln Leu Glu Leu Met Pro Asn Ile Glu Arg Phe 
                805                 810                 815     


Pro Asn Gly Lys Lys Tyr Glu Leu Asp Lys Tyr Thr Met Phe His Tyr 
            820                 825                 830         


Leu Arg Ala Gln Glu Phe Glu His Gly Lys Ser Arg Ile Ala Leu Thr 
        835                 840                 845             


Asn Ser Val Asn Glu Ala Leu Leu Asn Pro Ser Arg Val Tyr Thr Phe 
    850                 855                 860                 


Phe Ser Ser Asp Tyr Val Lys Lys Val Asn Lys Ala Thr Glu Ala Ala 
865                 870                 875                 880 


Met Phe Leu Gly Trp Val Glu Gln Leu Val Tyr Asp Phe Thr Asp Glu 
                885                 890                 895     


Thr Ser Glu Val Ser Thr Thr Asp Lys Ile Ala Asp Ile Thr Ile Ile 
            900                 905                 910         


Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile Gly Asn Met Leu Tyr Lys 
        915                 920                 925             


Asp Asp Phe Val Gly Ala Leu Ile Phe Ser Gly Ala Val Ile Leu Leu 
    930                 935                 940                 


Glu Phe Ile Pro Glu Ile Ala Ile Pro Val Leu Gly Thr Phe Ala Leu 
945                 950                 955                 960 


Val Ser Tyr Ile Ala Asn Lys Val Leu Thr Val Gln Thr Ile Asp Asn 
                965                 970                 975     


Ala Leu Ser Lys Arg Asn Glu Lys Trp Asp Glu Val Tyr Lys Tyr Ile 
            980                 985                 990         


Val Thr Asn Trp Leu Ala Lys Val  Asn Thr Gln Ile Asp  Leu Ile Arg 
        995                 1000                 1005             


Lys Lys  Met Lys Glu Ala Leu  Glu Asn Gln Ala Glu  Ala Thr Lys 
    1010                 1015                 1020             


Ala Ile  Ile Asn Tyr Gln Tyr  Asn Gln Tyr Thr Glu  Glu Glu Lys 
    1025                 1030                 1035             


Asn Asn  Ile Asn Phe Asn Ile  Asp Asp Leu Ser Ser  Lys Leu Asn 
    1040                 1045                 1050             


Glu Ser  Ile Asn Lys Ala Met  Ile Asn Ile Asn Lys  Phe Leu Asn 
    1055                 1060                 1065             


Gln Cys  Ser Val Ser Tyr Leu  Met Asn Ser Met Ile  Pro Tyr Gly 
    1070                 1075                 1080             


Val Lys  Arg Leu Glu Asp Phe  Asp Ala Ser Leu Lys  Asp Ala Leu 
    1085                 1090                 1095             


Leu Lys  Tyr Ile Tyr Asp Asn  Arg Gly Thr Leu Ile  Gly Gln Val 
    1100                 1105                 1110             


Asp Arg  Leu Lys Asp Lys Val  Asn Asn Thr Leu Ser  Thr Asp Ile 
    1115                 1120                 1125             


Pro Phe  Gln Leu Ser Lys Tyr  Val Asp Asn Gln Arg  Leu Leu Ser 
    1130                 1135                 1140             


Thr Phe  Thr Glu Tyr Ile Asn  Asn Ile Ile Asn Thr  Ser Ile Leu 
    1145                 1150                 1155             


Asn Leu  Arg Tyr Glu Ser Asn  His Leu Ile Asp Leu  Ser Arg Tyr 
    1160                 1165                 1170             


Ala Ser  Lys Ile Asn Ile Gly  Ser Lys Val Asn Phe  Asp Pro Ile 
    1175                 1180                 1185             


Asp Lys  Asn Gln Ile Gln Leu  Phe Asn Leu Glu Ser  Ser Lys Ile 
    1190                 1195                 1200             


Glu Val  Ile Leu Lys Asn Ala  Ile Val Tyr Asn Ser  Met Tyr Glu 
    1205                 1210                 1215             


Asn Phe  Ser Thr Ser Phe Trp  Ile Arg Ile Pro Lys  Tyr Phe Asn 
    1220                 1225                 1230             


Ser Ile  Ser Leu Asn Asn Glu  Tyr Thr Ile Ile Asn  Cys Met Glu 
    1235                 1240                 1245             


Asn Asn  Ser Gly Trp Lys Val  Ser Leu Asn Tyr Gly  Glu Ile Ile 
    1250                 1255                 1260             


Trp Thr  Leu Gln Asp Thr Gln  Glu Ile Lys Gln Arg  Val Val Phe 
    1265                 1270                 1275             


Lys Tyr  Ser Gln Met Ile Asn  Ile Ser Asp Tyr Ile  Asn Arg Trp 
    1280                 1285                 1290             


Ile Phe  Val Thr Ile Thr Asn  Asn Arg Leu Asn Asn  Ser Lys Ile 
    1295                 1300                 1305             


Tyr Ile  Asn Gly Arg Leu Ile  Asp Gln Lys Pro Ile  Ser Asn Leu 
    1310                 1315                 1320             


Gly Asn  Ile His Ala Ser Asn  Asn Ile Met Phe Lys  Leu Asp Gly 
    1325                 1330                 1335             


Cys Arg  Asp Thr His Arg Tyr  Ile Trp Ile Lys Tyr  Phe Asn Leu 
    1340                 1345                 1350             


Phe Asp  Lys Glu Leu Asn Glu  Lys Glu Ile Lys Asp  Leu Tyr Asp 
    1355                 1360                 1365             


Asn Gln  Ser Asn Ser Gly Ile  Leu Lys Asp Phe Trp  Gly Asp Tyr 
    1370                 1375                 1380             


Leu Gln  Tyr Asp Lys Pro Tyr  Tyr Met Leu Asn Leu  Tyr Asp Pro 
    1385                 1390                 1395             


Asn Lys  Tyr Val Asp Val Asn  Asn Val Gly Ile Arg  Gly Tyr Met 
    1400                 1405                 1410             


Tyr Leu  Lys Gly Pro Arg Gly  Ser Val Met Thr Thr  Asn Ile Tyr 
    1415                 1420                 1425             


Leu Asn  Ser Ser Leu Tyr Arg  Gly Thr Lys Phe Ile  Ile Lys Lys 
    1430                 1435                 1440             


Tyr Ala  Ser Gly Asn Lys Asp  Asn Ile Val Arg Asn  Asn Asp Arg 
    1445                 1450                 1455             


Val Tyr  Ile Asn Val Val Val  Lys Asn Lys Glu Tyr  Arg Leu Ala 
    1460                 1465                 1470             


Thr Asn  Ala Ser Gln Ala Gly  Val Glu Lys Ile Leu  Ser Ala Leu 
    1475                 1480                 1485             


Glu Ile  Pro Asp Val Gly Asn  Leu Ser Gln Val Val  Val Met Lys 
    1490                 1495                 1500             


Ser Lys  Asn Asp Gln Gly Ile  Thr Asn Lys Cys Lys  Met Asn Leu 
    1505                 1510                 1515             


Gln Asp  Asn Asn Gly Asn Asp  Ile Gly Phe Ile Gly  Phe His Gln 
    1520                 1525                 1530             


Phe Asn  Asn Ile Ala Lys Leu  Val Ala Ser Asn Trp  Tyr Asn Arg 
    1535                 1540                 1545             


Gln Ile  Glu Arg Ser Ser Arg  Thr Leu Gly Cys Ser  Trp Glu Phe 
    1550                 1555                 1560             


Ile Pro  Val Asp Asp Gly Trp  Gly Glu Arg Pro Leu  Gly Ala Gly 
    1565                 1570                 1575             


Tyr Pro  Tyr Asp Val Pro Asp  Tyr Ala Gly Glu Asn  Leu Tyr Phe 
    1580                 1585                 1590             


Gln Gly  Ala Gly Trp Ser His  Pro Gln Phe Glu Lys  Gly Ala Gly 
    1595                 1600                 1605             


Trp Ser  His Pro Gln Phe Glu  Lys Gly Ala Gly Trp  Ser His Pro 
    1610                 1615                 1620             


Gln Phe  Glu Lys 
    1625         


<210>  9
<211>  4801
<212>  DNA
<213>  Artificial

<220>
<223>  Propeptide fusion encoding sequence

<400>  9
ggatcccggt ccgttcgaac cagaactctg gaagcttaac tcctaaaaaa ccgccaccat       60

gaaattctta gtcaacgttg cccttgtttt tatggtcgta tacatttctt acatctatgc      120

ggccggacac caccaccacc accaccacca ccaccaccac gacgtcgaga acctgtactt      180

ccaaggagca gaacaaaagt tgatttcgga ggaggacctg ggtggtgggg cccacggtgg      240

cgcacaggcg cacgtgcaac tgcagcagtc tggaggaggc ttggtgcagc ctgggggttc      300

cctgcgcctg tcatgtgcag cctctggaag catcttcagt atttacgcta tgggctggta      360

caggcaggct cctggcaagc aacgtgaact ggttgctgcc atctccagct acggtagtac      420

caactacgct gattcggtca agggcaggtt caccatctcc cgcgacaatg ccaagaatac      480

cgtctatttg caaatgaact ctctgaaacc tgaggatacg gccgtctact actgcaacgc      540

tgacattgct actatgaccg cggtaggcgg attcgactac tggggacagg gaactcaggt      600

gacggtctct tccgaaccta agacccctaa accccaagcg ggccaaggcg ctccagtccc      660

atacccagac ccactcgaac ccaggggcac gcgtggagcg ggagctggac cgatcaccat      720

caacaacttc aattacagcg acccggtgga taacaagaac atcctctact tggacacaca      780

cttgaacacg ctggctaacg agcctgaaaa agctttcagg atcaccggca acatttgggt      840

cattccggat aggttcagca gaaactctaa ccctaacttg aacaaacctc ccagagtgac      900

ctcacctaag agtggatact acgaccccaa ctacctctcg actgactccg ataaagaccc      960

cttcctgaag gagatcatta aactcttcaa gcgcatcaac tctcgtgaaa ttggcgagga     1020

attgatctac cgcctgagta cagacatccc attcccgggt aacaacaaca ccccaatcaa     1080

cactttcgat ttcgatgtcg atttcaactc agtggatgtc aaaaccaggc agggaaacaa     1140

ctgggtgaag actggtagca tcaacccatc tgtcatcatt actggcccga gagagaacat     1200

cattgaccct gaaacctcca ctttcaagct gacaaacaac acgttcgctg ctcaggaagg     1260

cttcggagcg ttgagcatca tttctatctc acctcgcttc atgctgacat actctaacgc     1320

tacgaacgac gtgggagagg gccgtttcag taagtctgaa ttctgcatgg accctattct     1380

gatcctcatg cacgctctca acggcgccat gcacaacttg tacggaattg ctatccccaa     1440

cgaccagacc atttccagcg tgactagcaa catcttctac tctcaataca acgtcaagct     1500

ggagtacgca gaaatctacg ctttcggtgg cccaaccatt gacttgatcc cgaaatcagc     1560

tcgtaagtat ttcgaagaaa aagcgctgga ttattacagg tcgattgcta agagactcaa     1620

ctccatcacc actgctaacc cctcttcatt caacaagtac attggagaat acaagcagaa     1680

actgatccgc aagtaccgtt tcgtggtcga gagttcgggt gaagttactg tgaaccgcaa     1740

caagttcgtc gagctgtaca acgaattgac acaaatcttc acggagttca actacgccaa     1800

aatttacaac gtgcaaaacc gtaagatcgc gctctctaac gtctacaccc cggttaccgc     1860

taacatcttg gacgataacg tctacgacat tcagaacggt ttcaacatcc caaagtcgaa     1920

cctcaacgtt ttgttcatgg gtcaaaactt gtcccgcaac cccgccctgc gtaaggtgaa     1980

cccagagaac atgttgtacc tgttcaccaa attctgccac aaggccatcg acggtcagtc     2040

tctagaccaa ggaggagaga acctctactt ccaaggtgct ggcaccctgg actgtcgcga     2100

actgctcgtt aagaacactg atctcccatt cattggcgac atctctgatg tgaaaacaga     2160

cattttcctg cgtaaggata tcaacgagga aacggaggtc atctactacc ctgacaacgt     2220

ctcggttgat caggttatct tgtcaaagaa caccagtgaa catggccaac tggacttgct     2280

gtacccctca attgattccg agagcgaaat cctgccagga gagaaccagg ttttctacga     2340

caacaggaca caaaacgtgg attacctcaa cagctactac tacctggagt cgcagaagct     2400

ctccgacaac gtcgaagatt tcacatttac gagatcaatc gaggaggctt tggacaacag     2460

tgccaaagtc tacacctact tccctactct ggcaaacaag gtgaacgcgg gtgtccaagg     2520

cggactcttc ttgatgtggg ctaacgacgt tgtggaagat ttcacaacga acatcttgcg     2580

caaagacacc ctggataaga tcagcgatgt ctctgccatc attccataca ttggcccggc     2640

actgaacatc tctaactcag ttcgccgtgg caacttcact gaggcattcg cggtcacagg     2700

agttacgatc ctcttggagg ctttcccgga gttcacaatc cccgcactgg gcgcgttcgt     2760

tatctactcc aaagtgcagg agcgcaacga aatcattaag actatcgaca actgcctgga     2820

gcaaaggatc aaaagatgga aggattcgta cgaatggatg atgggtacct ggctctcccg     2880

tatcattacg cagttcaaca acatcagcta ccaaatgtac gactctctca actaccaggc     2940

tggtgccatc aaggccaaaa ttgacttgga gtacaagaaa tacagtggct cggataaaga     3000

gaacatcaag agtcaagtcg aaaacctgaa aaactcactc gacgttaaga tcagtgaggc     3060

aatgaacaac atcaacaagt tcattcgcga atgttccgtt acctacctct tcaaaaacat     3120

gttgccaaag gtcatcgacg agctgaacga atttgatcgt aacactaagg cgaaactgat     3180

taacctcatc gactcacaca acatcatttt ggtgggcgaa gtcgataagc tgaaagccaa     3240

ggtgaacaac agtttccaga acacaatccc tttcaacatt ttctcataca cgaacaacag     3300

tctgctcaag gacatcatta acgagtactt caacaacatt aacgatagca aaatcctgtc     3360

actgcagaac cgtaagaaca cactggtcga tactagtgga tacaacgccg aagtctctga     3420

ggaaggtgac gtgcagctga accctatctt ccccttcgac ttcaaattgg gctccagcgg     3480

agaggatagg ggcaaggtca tcgtcaccca gaacgagaac atcgtctaca actcaatgta     3540

cgaatccttc agcatctctt tctggatcag gattaacaag tgggtgagca acctgcccgg     3600

ttacacaatc attgactctg tcaagaacaa ctcaggttgg agtatcggca tcatttctaa     3660

cttcttggtc ttcaccctga agcagaacga ggactcggaa caatccatta acttctcata     3720

cgatatcagt aacaacgctc caggttacaa caagtggttc ttcgttaccg tgactaacaa     3780

catgatgggt aacatgaaaa tttacatcaa cggcaagctc attgacacca tcaaagtgaa     3840

ggagttgact ggtattaact tctccaaaac aatcacgttt gaaattaaca agatccctga     3900

caccggcctg atcacttcag acagtgataa catcaacatg tggattaggg atttctacat     3960

cttcgccaag gagctcgacg gaaaggatat taacatcctc ttcaacagct tgcagtacac     4020

caacgtcgtt aaagactact ggggtaacga tttgagatac aacaaggagt actacatggt     4080

caacatcgac tacctgaaca ggtacatgta cgctaactcc cgccaaatcg tgttcaacac     4140

caggagaaac aacaacgact tcaacgaggg ttacaaaatc attatcaagc gcatccgtgg     4200

caacaccaac gatactaggg tgagaggtgg cgacattctg tacttcgata tgactatcaa     4260

caacaaagcc tacaacttgt tcatgaaaaa cgagacaatg tacgccgaca accatagcac     4320

ggaggatatt tacgcaatcg gactgaggga acagacaaag gacatcaacg ataacattat     4380

cttccagatc caacctatga acaacacgta ctactacgct tcgcaaatct tcaagtccaa     4440

cttcaacgga gaaaacattt cgggtatctg ttccattggc acataccgct tccgtctggg     4500

tggtgactgg tatcgtcaca actacctcgt tcccaccgtg aagcagggta actacgcttc     4560

tttgctggag tcgacctcca ctcattgggg attcgttcca gtttcagaag gagcgggata     4620

cccatacgac gtgcccgact atgctggtga gaacctgtac ttccagggcg ctggttggtc     4680

ccaccctcag ttcgagaagg gagcgggatg gtcacacccg cagtttgaga aaggcgcagg     4740

ttggtcacat ccccagttcg agaagtaatt agttgatgca tagttaatta gatagctcga     4800

g                                                                     4801


<210>  10
<211>  1569
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein

<400>  10

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ala Gly His His His His His His His His His 
            20                  25                  30          


His His Asp Val Glu Asn Leu Tyr Phe Gln Gly Ala Glu Gln Lys Leu 
        35                  40                  45              


Ile Ser Glu Glu Asp Leu Gly Gly Gly Ala His Gly Gly Ala Gln Ala 
    50                  55                  60                  


His Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
65                  70                  75                  80  


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Tyr 
                85                  90                  95      


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
            100                 105                 110         


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
        115                 120                 125             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
    130                 135                 140                 


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
145                 150                 155                 160 


Ala Asp Ile Ala Thr Met Thr Ala Val Gly Gly Phe Asp Tyr Trp Gly 
                165                 170                 175     


Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro 
            180                 185                 190         


Gln Ala Gly Gln Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro 
        195                 200                 205             


Arg Gly Thr Arg Gly Ala Gly Ala Gly Pro Ile Thr Ile Asn Asn Phe 
    210                 215                 220                 


Asn Tyr Ser Asp Pro Val Asp Asn Lys Asn Ile Leu Tyr Leu Asp Thr 
225                 230                 235                 240 


His Leu Asn Thr Leu Ala Asn Glu Pro Glu Lys Ala Phe Arg Ile Thr 
                245                 250                 255     


Gly Asn Ile Trp Val Ile Pro Asp Arg Phe Ser Arg Asn Ser Asn Pro 
            260                 265                 270         


Asn Leu Asn Lys Pro Pro Arg Val Thr Ser Pro Lys Ser Gly Tyr Tyr 
        275                 280                 285             


Asp Pro Asn Tyr Leu Ser Thr Asp Ser Asp Lys Asp Pro Phe Leu Lys 
    290                 295                 300                 


Glu Ile Ile Lys Leu Phe Lys Arg Ile Asn Ser Arg Glu Ile Gly Glu 
305                 310                 315                 320 


Glu Leu Ile Tyr Arg Leu Ser Thr Asp Ile Pro Phe Pro Gly Asn Asn 
                325                 330                 335     


Asn Thr Pro Ile Asn Thr Phe Asp Phe Asp Val Asp Phe Asn Ser Val 
            340                 345                 350         


Asp Val Lys Thr Arg Gln Gly Asn Asn Trp Val Lys Thr Gly Ser Ile 
        355                 360                 365             


Asn Pro Ser Val Ile Ile Thr Gly Pro Arg Glu Asn Ile Ile Asp Pro 
    370                 375                 380                 


Glu Thr Ser Thr Phe Lys Leu Thr Asn Asn Thr Phe Ala Ala Gln Glu 
385                 390                 395                 400 


Gly Phe Gly Ala Leu Ser Ile Ile Ser Ile Ser Pro Arg Phe Met Leu 
                405                 410                 415     


Thr Tyr Ser Asn Ala Thr Asn Asp Val Gly Glu Gly Arg Phe Ser Lys 
            420                 425                 430         


Ser Glu Phe Cys Met Asp Pro Ile Leu Ile Leu Met His Ala Leu Asn 
        435                 440                 445             


Gly Ala Met His Asn Leu Tyr Gly Ile Ala Ile Pro Asn Asp Gln Thr 
    450                 455                 460                 


Ile Ser Ser Val Thr Ser Asn Ile Phe Tyr Ser Gln Tyr Asn Val Lys 
465                 470                 475                 480 


Leu Glu Tyr Ala Glu Ile Tyr Ala Phe Gly Gly Pro Thr Ile Asp Leu 
                485                 490                 495     


Ile Pro Lys Ser Ala Arg Lys Tyr Phe Glu Glu Lys Ala Leu Asp Tyr 
            500                 505                 510         


Tyr Arg Ser Ile Ala Lys Arg Leu Asn Ser Ile Thr Thr Ala Asn Pro 
        515                 520                 525             


Ser Ser Phe Asn Lys Tyr Ile Gly Glu Tyr Lys Gln Lys Leu Ile Arg 
    530                 535                 540                 


Lys Tyr Arg Phe Val Val Glu Ser Ser Gly Glu Val Thr Val Asn Arg 
545                 550                 555                 560 


Asn Lys Phe Val Glu Leu Tyr Asn Glu Leu Thr Gln Ile Phe Thr Glu 
                565                 570                 575     


Phe Asn Tyr Ala Lys Ile Tyr Asn Val Gln Asn Arg Lys Ile Ala Leu 
            580                 585                 590         


Ser Asn Val Tyr Thr Pro Val Thr Ala Asn Ile Leu Asp Asp Asn Val 
        595                 600                 605             


Tyr Asp Ile Gln Asn Gly Phe Asn Ile Pro Lys Ser Asn Leu Asn Val 
    610                 615                 620                 


Leu Phe Met Gly Gln Asn Leu Ser Arg Asn Pro Ala Leu Arg Lys Val 
625                 630                 635                 640 


Asn Pro Glu Asn Met Leu Tyr Leu Phe Thr Lys Phe Cys His Lys Ala 
                645                 650                 655     


Ile Asp Gly Gln Ser Leu Asp Gln Gly Gly Glu Asn Leu Tyr Phe Gln 
            660                 665                 670         


Gly Ala Gly Thr Leu Asp Cys Arg Glu Leu Leu Val Lys Asn Thr Asp 
        675                 680                 685             


Leu Pro Phe Ile Gly Asp Ile Ser Asp Val Lys Thr Asp Ile Phe Leu 
    690                 695                 700                 


Arg Lys Asp Ile Asn Glu Glu Thr Glu Val Ile Tyr Tyr Pro Asp Asn 
705                 710                 715                 720 


Val Ser Val Asp Gln Val Ile Leu Ser Lys Asn Thr Ser Glu His Gly 
                725                 730                 735     


Gln Leu Asp Leu Leu Tyr Pro Ser Ile Asp Ser Glu Ser Glu Ile Leu 
            740                 745                 750         


Pro Gly Glu Asn Gln Val Phe Tyr Asp Asn Arg Thr Gln Asn Val Asp 
        755                 760                 765             


Tyr Leu Asn Ser Tyr Tyr Tyr Leu Glu Ser Gln Lys Leu Ser Asp Asn 
    770                 775                 780                 


Val Glu Asp Phe Thr Phe Thr Arg Ser Ile Glu Glu Ala Leu Asp Asn 
785                 790                 795                 800 


Ser Ala Lys Val Tyr Thr Tyr Phe Pro Thr Leu Ala Asn Lys Val Asn 
                805                 810                 815     


Ala Gly Val Gln Gly Gly Leu Phe Leu Met Trp Ala Asn Asp Val Val 
            820                 825                 830         


Glu Asp Phe Thr Thr Asn Ile Leu Arg Lys Asp Thr Leu Asp Lys Ile 
        835                 840                 845             


Ser Asp Val Ser Ala Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile 
    850                 855                 860                 


Ser Asn Ser Val Arg Arg Gly Asn Phe Thr Glu Ala Phe Ala Val Thr 
865                 870                 875                 880 


Gly Val Thr Ile Leu Leu Glu Ala Phe Pro Glu Phe Thr Ile Pro Ala 
                885                 890                 895     


Leu Gly Ala Phe Val Ile Tyr Ser Lys Val Gln Glu Arg Asn Glu Ile 
            900                 905                 910         


Ile Lys Thr Ile Asp Asn Cys Leu Glu Gln Arg Ile Lys Arg Trp Lys 
        915                 920                 925             


Asp Ser Tyr Glu Trp Met Met Gly Thr Trp Leu Ser Arg Ile Ile Thr 
    930                 935                 940                 


Gln Phe Asn Asn Ile Ser Tyr Gln Met Tyr Asp Ser Leu Asn Tyr Gln 
945                 950                 955                 960 


Ala Gly Ala Ile Lys Ala Lys Ile Asp Leu Glu Tyr Lys Lys Tyr Ser 
                965                 970                 975     


Gly Ser Asp Lys Glu Asn Ile Lys Ser Gln Val Glu Asn Leu Lys Asn 
            980                 985                 990         


Ser Leu Asp Val Lys Ile Ser Glu  Ala Met Asn Asn Ile  Asn Lys Phe 
        995                 1000                 1005             


Ile Arg  Glu Cys Ser Val Thr  Tyr Leu Phe Lys Asn  Met Leu Pro 
    1010                 1015                 1020             


Lys Val  Ile Asp Glu Leu Asn  Glu Phe Asp Arg Asn  Thr Lys Ala 
    1025                 1030                 1035             


Lys Leu  Ile Asn Leu Ile Asp  Ser His Asn Ile Ile  Leu Val Gly 
    1040                 1045                 1050             


Glu Val  Asp Lys Leu Lys Ala  Lys Val Asn Asn Ser  Phe Gln Asn 
    1055                 1060                 1065             


Thr Ile  Pro Phe Asn Ile Phe  Ser Tyr Thr Asn Asn  Ser Leu Leu 
    1070                 1075                 1080             


Lys Asp  Ile Ile Asn Glu Tyr  Phe Asn Asn Ile Asn  Asp Ser Lys 
    1085                 1090                 1095             


Ile Leu  Ser Leu Gln Asn Arg  Lys Asn Thr Leu Val  Asp Thr Ser 
    1100                 1105                 1110             


Gly Tyr  Asn Ala Glu Val Ser  Glu Glu Gly Asp Val  Gln Leu Asn 
    1115                 1120                 1125             


Pro Ile  Phe Pro Phe Asp Phe  Lys Leu Gly Ser Ser  Gly Glu Asp 
    1130                 1135                 1140             


Arg Gly  Lys Val Ile Val Thr  Gln Asn Glu Asn Ile  Val Tyr Asn 
    1145                 1150                 1155             


Ser Met  Tyr Glu Ser Phe Ser  Ile Ser Phe Trp Ile  Arg Ile Asn 
    1160                 1165                 1170             


Lys Trp  Val Ser Asn Leu Pro  Gly Tyr Thr Ile Ile  Asp Ser Val 
    1175                 1180                 1185             


Lys Asn  Asn Ser Gly Trp Ser  Ile Gly Ile Ile Ser  Asn Phe Leu 
    1190                 1195                 1200             


Val Phe  Thr Leu Lys Gln Asn  Glu Asp Ser Glu Gln  Ser Ile Asn 
    1205                 1210                 1215             


Phe Ser  Tyr Asp Ile Ser Asn  Asn Ala Pro Gly Tyr  Asn Lys Trp 
    1220                 1225                 1230             


Phe Phe  Val Thr Val Thr Asn  Asn Met Met Gly Asn  Met Lys Ile 
    1235                 1240                 1245             


Tyr Ile  Asn Gly Lys Leu Ile  Asp Thr Ile Lys Val  Lys Glu Leu 
    1250                 1255                 1260             


Thr Gly  Ile Asn Phe Ser Lys  Thr Ile Thr Phe Glu  Ile Asn Lys 
    1265                 1270                 1275             


Ile Pro  Asp Thr Gly Leu Ile  Thr Ser Asp Ser Asp  Asn Ile Asn 
    1280                 1285                 1290             


Met Trp  Ile Arg Asp Phe Tyr  Ile Phe Ala Lys Glu  Leu Asp Gly 
    1295                 1300                 1305             


Lys Asp  Ile Asn Ile Leu Phe  Asn Ser Leu Gln Tyr  Thr Asn Val 
    1310                 1315                 1320             


Val Lys  Asp Tyr Trp Gly Asn  Asp Leu Arg Tyr Asn  Lys Glu Tyr 
    1325                 1330                 1335             


Tyr Met  Val Asn Ile Asp Tyr  Leu Asn Arg Tyr Met  Tyr Ala Asn 
    1340                 1345                 1350             


Ser Arg  Gln Ile Val Phe Asn  Thr Arg Arg Asn Asn  Asn Asp Phe 
    1355                 1360                 1365             


Asn Glu  Gly Tyr Lys Ile Ile  Ile Lys Arg Ile Arg  Gly Asn Thr 
    1370                 1375                 1380             


Asn Asp  Thr Arg Val Arg Gly  Gly Asp Ile Leu Tyr  Phe Asp Met 
    1385                 1390                 1395             


Thr Ile  Asn Asn Lys Ala Tyr  Asn Leu Phe Met Lys  Asn Glu Thr 
    1400                 1405                 1410             


Met Tyr  Ala Asp Asn His Ser  Thr Glu Asp Ile Tyr  Ala Ile Gly 
    1415                 1420                 1425             


Leu Arg  Glu Gln Thr Lys Asp  Ile Asn Asp Asn Ile  Ile Phe Gln 
    1430                 1435                 1440             


Ile Gln  Pro Met Asn Asn Thr  Tyr Tyr Tyr Ala Ser  Gln Ile Phe 
    1445                 1450                 1455             


Lys Ser  Asn Phe Asn Gly Glu  Asn Ile Ser Gly Ile  Cys Ser Ile 
    1460                 1465                 1470             


Gly Thr  Tyr Arg Phe Arg Leu  Gly Gly Asp Trp Tyr  Arg His Asn 
    1475                 1480                 1485             


Tyr Leu  Val Pro Thr Val Lys  Gln Gly Asn Tyr Ala  Ser Leu Leu 
    1490                 1495                 1500             


Glu Ser  Thr Ser Thr His Trp  Gly Phe Val Pro Val  Ser Glu Gly 
    1505                 1510                 1515             


Ala Gly  Tyr Pro Tyr Asp Val  Pro Asp Tyr Ala Gly  Glu Asn Leu 
    1520                 1525                 1530             


Tyr Phe  Gln Gly Ala Gly Trp  Ser His Pro Gln Phe  Glu Lys Gly 
    1535                 1540                 1545             


Ala Gly  Trp Ser His Pro Gln  Phe Glu Lys Gly Ala  Gly Trp Ser 
    1550                 1555                 1560             


His Pro  Gln Phe Glu Lys 
    1565                 


<210>  11
<211>  4804
<212>  DNA
<213>  Artificial

<220>
<223>  Propeptide fusion encoding sequence

<400>  11
ggatcccggt ccgttcgaac cagaactctg gaagcttaac tcctaaaaaa ccgccaccat       60

gaaattctta gtcaacgttg cccttgtttt tatggtcgta tacatttctt acatctatgc      120

ggccggacac caccaccacc accaccacca ccaccaccac gacgtcgaaa acctgtactt      180

ccaaggtgca gagcagaaac tcatcagcga agaagatttg ggagcaggcg cagcacaact      240

ccagctcgtt gagtccggtg gcggaatggt gcaacctggt ggctctttga ggctgtcatg      300

cgctgccagt ggattcacct tctcgactta cgacatgtcc tgggtgcgtc aggcacctgg      360

aaaaggtccc gaatgggtca gcatcattaa cgctggaggt ggcagcacat actacgcagc      420

gtctgttaag ggaaggttcg ctatctccag agacaacgcc aaaaacaccc tctacttgca      480

aatgaacaac ctgaagcccg aggatactgc tctctactac tgtgctcgcg tcgcctcata      540

ctactgccgt ggctacgttt gtagtcctcc cgagttcgac tactggggcc agggaacaca      600

agtgacggtc tccagcgaac caaagacacc aaaaccacag gctggtcagg gcgctcctgt      660

tccataccca gatccactgg aaccaagagg aacgcgtgga gcgggagcag gtccattcgt      720

caacaagcaa ttcaactaca aagatcctgt taacggtgtg gacatcgcct acatcaagat      780

tccgaacgca ggccagatgc aacctgtgaa ggctttcaaa atccacaaca agatctgggt      840

cattcccgag agagacacat tcacgaaccc agaggaaggt gatctgaacc ctcccccaga      900

agccaagcag gtgccggtct cttactacga ttcaacctac ctcagtactg acaacgagaa      960

ggataactac ctgaagggcg ttactaaact cttcgagcgc atctactcga cagacttggg     1020

ccgtatgctg ctcacgtcca tcgtcagggg tattcctttc tggggtggct caaccatcga     1080

cactgagctg aaggtcattg atacaaactg catcaacgtt attcaacccg acggctccta     1140

ccgcagcgag gaattgaacc tggtgatcat tggaccaagc gccgacatca ttcagttcga     1200

gtgtaagtct ttcggccatg aagtcctcaa cttgaccaga aacggctacg gctccactca     1260

atacatccgc ttcagccccg acttcacatt cggattcgag gaatcactgg aggtcgatac     1320

gaacccgttg ctgggtgctg gcaagttcgc caccgaccct gcagttactc tggcacacgc     1380

gctcatccac gcgggacatc gtctgtacgg tatcgctatt aacccaaaca gggtcttcaa     1440

ggttaacacc aacgcctact acgagatgag tggtctggaa gtgtcgttcg aggaactccg     1500

tacgttcgga ggtcacgacg caaagttcat cgatagtttg caggagaacg aattccgcct     1560

gtactactac aacaagttca aagacatcgc gtctacactc aacaaggcta aaagcattgt     1620

tggaaccact gctagtttgc aatacatgaa gaacgtgttc aaggagaaat acctcttgtc     1680

ggaagacacc tccggtaaat tcagcgtgga caagctgaaa ttcgataagt tgtacaaaat     1740

gctgacagaa atctacacgg aagacaactt cgttaagttc ttcaaagtgt tgaaccgtaa     1800

gaccgctctg aacttcgata aggctgtctt caaaatcaac attgtgccta aagtcaacta     1860

caccatctac gacggtttca acctccgcaa cactaacttg gctgccaact tcaacggcca     1920

gaacactgag atcaacaaca tgaacttcac aaagctcaaa aacttcaccg gtttgttcga     1980

gttctacaag ctgctctgcg tgcgtggtat cattacatct cacacgcaat ctctagacca     2040

gggtggcgag aacctgtact tccagggtgc tctgaacgat ctgtgtatca aggtgaataa     2100

ctgggatctg ttctttagcc caagcgagga taacttcacg aacgatctca acaaaggtga     2160

agagatcacg tctgatacca atatcgaagc ggctgaagag aatatctcct tggatctcat     2220

ccagcaatat tacctgacct ttaacttcga taacgagccc gaaaacatct ccatcgagaa     2280

cctcagctca gacatcattg gtcagttgga gctgatgcca aacattgaac gcttccccaa     2340

cggcaagaaa tacgaactcg acaagtatac gatgtttcat tacttaagag cgcaggagtt     2400

tgaacacggc aagagccgca ttgctctcac taactccgtg aatgaagccc tgctcaatcc     2460

gtcaagggtg tacacattct ttagctccga ctatgtcaag aaagtgaaca aagccaccga     2520

agcggcaatg ttcctgggat gggttgaaca actggtctac gacttcaccg acgagacctc     2580

tgaggtgagc acaacggaca agattgctga catcactatc attatcccgt atattggacc     2640

tgccttgaat attggcaaca tgctctacaa agacgatttc gttggtgccc tgatcttcag     2700

cggtgccgtg atcctgttgg agttcattcc tgaaatcgcc atccctgtgc tgggcacgtt     2760

cgctctggtc tcatacattg cgaataaggt cttgaccgtg cagacaatcg ataatgccct     2820

ctccaaacgt aacgaaaaat gggacgaggt ctacaaatac atcgtgacca actggctggc     2880

aaaggttaac acccaaattg atctgatccg taagaaaatg aaggaggctt tggagaacca     2940

ggctgaagct actaaagcca ttatcaacta ccagtataat cagtatacag aagaggaaaa     3000

gaataacatc aatttcaaca tcgatgactt gtcctcaaag ctgaacgagt ccatcaacaa     3060

agctatgatc aacatcaaca aattcctgaa tcagtgctcc gtgtcttacc tgatgaactc     3120

tatgatccca tacggtgtga agcgcctgga ggacttcgat gccagcctga aagacgcact     3180

gctcaaatac atttacgata atcgcggcac tttgattggc caagttgacc gtctgaagga     3240

caaggttaac aataccttgt caaccgatat ccccttccaa ctctctaagt acgtcgataa     3300

ccagcgcttg ctgagcacct tcacagaata catcaacaac atcatcaaca cctccatcct     3360

gaacctccgt tacgagtcta accacctcat cgacttgagc agatacgcta gcaagatcaa     3420

catcggttcc aaggtgaact tcgacccaat cgataagaac cagatccaac tgttcaacct     3480

cgaatcctct aagatcgaag tgatcctgaa gaacgctatc gtctacaact ccatgtacga     3540

aaacttctct accagcttct ggatcaggat tccgaaatac ttcaactcaa tctcgctcaa     3600

caacgagtac actatcatca actgcatgga aaacaactcg ggatggaagg tgtccctcaa     3660

ctacggcgag atcatctgga ctttgcagga cacacaagaa atcaagcaga gggtcgtgtt     3720

caagtacagc caaatgatca acatcagcga ttacatcaac cgttggatct tcgtcacaat     3780

caccaacaac cgcctgaaca actccaagat ttacatcaac ggtagactga tcgaccagaa     3840

gccaatcagc aacctcggca acatccacgc ctcaaacaac atcatgttca agttggacgg     3900

ctgtagggat acacacagat acatctggat caaatacttc aacctgttcg acaaggagct     3960

caacgagaag gaaatcaagg acctctacga taaccagtcc aactctggta tcttgaagga     4020

cttctggggc gattacctgc aatacgacaa gccctactac atgttgaacc tgtacgaccc     4080

taacaagtac gttgatgtga acaacgtcgg tatcaggggc tacatgtacc tgaagggacc     4140

acgtggttct gttatgacca ctaacatcta cctcaacagc tcattgtacc gtggcacaaa     4200

gttcatcatc aagaagtacg cctccggaaa caaggacaac atcgtccgta acaacgatcg     4260

cgtttacatc aacgttgtgg tcaagaacaa ggagtacaga ctggctacca acgcttcgca     4320

ggctggagtt gagaagatcc tgtctgctct ggaaatccct gacgtgggca acctctcaca     4380

ggttgtggtc atgaagtcga agaacgatca aggcatcact aacaagtgca agatgaactt     4440

gcaggacaac aacggaaacg acatcggctt catcggattc caccaattca acaacatcgc     4500

caagttggtg gccagcaact ggtacaaccg tcagatcgag cgttcgtccc gcaccttagg     4560

atgctcgtgg gagttcattc cagtcgatga cggatgggga gagagacctt tgggcgcagg     4620

atacccctac gatgtccctg actacgctgg agagaacctg tacttccagg gtgcaggatg     4680

gtcccaccca caattcgaga agggtgcagg atggagtcac ccacagttcg agaagggcgc     4740

tggatggtcc cacccacagt tcgagaaata attagttgat gcatagttaa ttagatagct     4800

cgag                                                                  4804


<210>  12
<211>  1570
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein

<400>  12

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ala Gly His His His His His His His His His 
            20                  25                  30          


His His Asp Val Glu Asn Leu Tyr Phe Gln Gly Ala Glu Gln Lys Leu 
        35                  40                  45              


Ile Ser Glu Glu Asp Leu Gly Ala Gly Ala Ala Gln Leu Gln Leu Val 
    50                  55                  60                  


Glu Ser Gly Gly Gly Met Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
65                  70                  75                  80  


Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr Asp Met Ser Trp Val 
                85                  90                  95      


Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Ile Ile Asn Ala 
            100                 105                 110         


Gly Gly Gly Ser Thr Tyr Tyr Ala Ala Ser Val Lys Gly Arg Phe Ala 
        115                 120                 125             


Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Asn 
    130                 135                 140                 


Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg Val Ala Ser 
145                 150                 155                 160 


Tyr Tyr Cys Arg Gly Tyr Val Cys Ser Pro Pro Glu Phe Asp Tyr Trp 
                165                 170                 175     


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys 
            180                 185                 190         


Pro Gln Ala Gly Gln Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu 
        195                 200                 205             


Pro Arg Gly Thr Arg Gly Ala Gly Ala Gly Pro Phe Val Asn Lys Gln 
    210                 215                 220                 


Phe Asn Tyr Lys Asp Pro Val Asn Gly Val Asp Ile Ala Tyr Ile Lys 
225                 230                 235                 240 


Ile Pro Asn Ala Gly Gln Met Gln Pro Val Lys Ala Phe Lys Ile His 
                245                 250                 255     


Asn Lys Ile Trp Val Ile Pro Glu Arg Asp Thr Phe Thr Asn Pro Glu 
            260                 265                 270         


Glu Gly Asp Leu Asn Pro Pro Pro Glu Ala Lys Gln Val Pro Val Ser 
        275                 280                 285             


Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr 
    290                 295                 300                 


Leu Lys Gly Val Thr Lys Leu Phe Glu Arg Ile Tyr Ser Thr Asp Leu 
305                 310                 315                 320 


Gly Arg Met Leu Leu Thr Ser Ile Val Arg Gly Ile Pro Phe Trp Gly 
                325                 330                 335     


Gly Ser Thr Ile Asp Thr Glu Leu Lys Val Ile Asp Thr Asn Cys Ile 
            340                 345                 350         


Asn Val Ile Gln Pro Asp Gly Ser Tyr Arg Ser Glu Glu Leu Asn Leu 
        355                 360                 365             


Val Ile Ile Gly Pro Ser Ala Asp Ile Ile Gln Phe Glu Cys Lys Ser 
    370                 375                 380                 


Phe Gly His Glu Val Leu Asn Leu Thr Arg Asn Gly Tyr Gly Ser Thr 
385                 390                 395                 400 


Gln Tyr Ile Arg Phe Ser Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser 
                405                 410                 415     


Leu Glu Val Asp Thr Asn Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr 
            420                 425                 430         


Asp Pro Ala Val Thr Leu Ala His Ala Leu Ile His Ala Gly His Arg 
        435                 440                 445             


Leu Tyr Gly Ile Ala Ile Asn Pro Asn Arg Val Phe Lys Val Asn Thr 
    450                 455                 460                 


Asn Ala Tyr Tyr Glu Met Ser Gly Leu Glu Val Ser Phe Glu Glu Leu 
465                 470                 475                 480 


Arg Thr Phe Gly Gly His Asp Ala Lys Phe Ile Asp Ser Leu Gln Glu 
                485                 490                 495     


Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn Lys Phe Lys Asp Ile Ala Ser 
            500                 505                 510         


Thr Leu Asn Lys Ala Lys Ser Ile Val Gly Thr Thr Ala Ser Leu Gln 
        515                 520                 525             


Tyr Met Lys Asn Val Phe Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr 
    530                 535                 540                 


Ser Gly Lys Phe Ser Val Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys 
545                 550                 555                 560 


Met Leu Thr Glu Ile Tyr Thr Glu Asp Asn Phe Val Lys Phe Phe Lys 
                565                 570                 575     


Val Leu Asn Arg Lys Thr Ala Leu Asn Phe Asp Lys Ala Val Phe Lys 
            580                 585                 590         


Ile Asn Ile Val Pro Lys Val Asn Tyr Thr Ile Tyr Asp Gly Phe Asn 
        595                 600                 605             


Leu Arg Asn Thr Asn Leu Ala Ala Asn Phe Asn Gly Gln Asn Thr Glu 
    610                 615                 620                 


Ile Asn Asn Met Asn Phe Thr Lys Leu Lys Asn Phe Thr Gly Leu Phe 
625                 630                 635                 640 


Glu Phe Tyr Lys Leu Leu Cys Val Arg Gly Ile Ile Thr Ser His Thr 
                645                 650                 655     


Gln Ser Leu Asp Gln Gly Gly Glu Asn Leu Tyr Phe Gln Gly Ala Leu 
            660                 665                 670         


Asn Asp Leu Cys Ile Lys Val Asn Asn Trp Asp Leu Phe Phe Ser Pro 
        675                 680                 685             


Ser Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu Ile Thr 
    690                 695                 700                 


Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu 
705                 710                 715                 720 


Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu Asn 
                725                 730                 735     


Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu 
            740                 745                 750         


Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu Leu Asp 
        755                 760                 765             


Lys Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu His Gly 
    770                 775                 780                 


Lys Ser Arg Ile Ala Leu Thr Asn Ser Val Asn Glu Ala Leu Leu Asn 
785                 790                 795                 800 


Pro Ser Arg Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys Lys Val 
                805                 810                 815     


Asn Lys Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu 
            820                 825                 830         


Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys 
        835                 840                 845             


Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn 
    850                 855                 860                 


Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu Ile Phe 
865                 870                 875                 880 


Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala Ile Pro 
                885                 890                 895     


Val Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys Val Leu 
            900                 905                 910         


Thr Val Gln Thr Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu Lys Trp 
        915                 920                 925             


Asp Glu Val Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys Val Asn 
    930                 935                 940                 


Thr Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu Glu Asn 
945                 950                 955                 960 


Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr 
                965                 970                 975     


Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser 
            980                 985                 990         


Ser Lys Leu Asn Glu Ser Ile Asn  Lys Ala Met Ile Asn  Ile Asn Lys 
        995                 1000                 1005             


Phe Leu  Asn Gln Cys Ser Val  Ser Tyr Leu Met Asn  Ser Met Ile 
    1010                 1015                 1020             


Pro Tyr  Gly Val Lys Arg Leu  Glu Asp Phe Asp Ala  Ser Leu Lys 
    1025                 1030                 1035             


Asp Ala  Leu Leu Lys Tyr Ile  Tyr Asp Asn Arg Gly  Thr Leu Ile 
    1040                 1045                 1050             


Gly Gln  Val Asp Arg Leu Lys  Asp Lys Val Asn Asn  Thr Leu Ser 
    1055                 1060                 1065             


Thr Asp  Ile Pro Phe Gln Leu  Ser Lys Tyr Val Asp  Asn Gln Arg 
    1070                 1075                 1080             


Leu Leu  Ser Thr Phe Thr Glu  Tyr Ile Asn Asn Ile  Ile Asn Thr 
    1085                 1090                 1095             


Ser Ile  Leu Asn Leu Arg Tyr  Glu Ser Asn His Leu  Ile Asp Leu 
    1100                 1105                 1110             


Ser Arg  Tyr Ala Ser Lys Ile  Asn Ile Gly Ser Lys  Val Asn Phe 
    1115                 1120                 1125             


Asp Pro  Ile Asp Lys Asn Gln  Ile Gln Leu Phe Asn  Leu Glu Ser 
    1130                 1135                 1140             


Ser Lys  Ile Glu Val Ile Leu  Lys Asn Ala Ile Val  Tyr Asn Ser 
    1145                 1150                 1155             


Met Tyr  Glu Asn Phe Ser Thr  Ser Phe Trp Ile Arg  Ile Pro Lys 
    1160                 1165                 1170             


Tyr Phe  Asn Ser Ile Ser Leu  Asn Asn Glu Tyr Thr  Ile Ile Asn 
    1175                 1180                 1185             


Cys Met  Glu Asn Asn Ser Gly  Trp Lys Val Ser Leu  Asn Tyr Gly 
    1190                 1195                 1200             


Glu Ile  Ile Trp Thr Leu Gln  Asp Thr Gln Glu Ile  Lys Gln Arg 
    1205                 1210                 1215             


Val Val  Phe Lys Tyr Ser Gln  Met Ile Asn Ile Ser  Asp Tyr Ile 
    1220                 1225                 1230             


Asn Arg  Trp Ile Phe Val Thr  Ile Thr Asn Asn Arg  Leu Asn Asn 
    1235                 1240                 1245             


Ser Lys  Ile Tyr Ile Asn Gly  Arg Leu Ile Asp Gln  Lys Pro Ile 
    1250                 1255                 1260             


Ser Asn  Leu Gly Asn Ile His  Ala Ser Asn Asn Ile  Met Phe Lys 
    1265                 1270                 1275             


Leu Asp  Gly Cys Arg Asp Thr  His Arg Tyr Ile Trp  Ile Lys Tyr 
    1280                 1285                 1290             


Phe Asn  Leu Phe Asp Lys Glu  Leu Asn Glu Lys Glu  Ile Lys Asp 
    1295                 1300                 1305             


Leu Tyr  Asp Asn Gln Ser Asn  Ser Gly Ile Leu Lys  Asp Phe Trp 
    1310                 1315                 1320             


Gly Asp  Tyr Leu Gln Tyr Asp  Lys Pro Tyr Tyr Met  Leu Asn Leu 
    1325                 1330                 1335             


Tyr Asp  Pro Asn Lys Tyr Val  Asp Val Asn Asn Val  Gly Ile Arg 
    1340                 1345                 1350             


Gly Tyr  Met Tyr Leu Lys Gly  Pro Arg Gly Ser Val  Met Thr Thr 
    1355                 1360                 1365             


Asn Ile  Tyr Leu Asn Ser Ser  Leu Tyr Arg Gly Thr  Lys Phe Ile 
    1370                 1375                 1380             


Ile Lys  Lys Tyr Ala Ser Gly  Asn Lys Asp Asn Ile  Val Arg Asn 
    1385                 1390                 1395             


Asn Asp  Arg Val Tyr Ile Asn  Val Val Val Lys Asn  Lys Glu Tyr 
    1400                 1405                 1410             


Arg Leu  Ala Thr Asn Ala Ser  Gln Ala Gly Val Glu  Lys Ile Leu 
    1415                 1420                 1425             


Ser Ala  Leu Glu Ile Pro Asp  Val Gly Asn Leu Ser  Gln Val Val 
    1430                 1435                 1440             


Val Met  Lys Ser Lys Asn Asp  Gln Gly Ile Thr Asn  Lys Cys Lys 
    1445                 1450                 1455             


Met Asn  Leu Gln Asp Asn Asn  Gly Asn Asp Ile Gly  Phe Ile Gly 
    1460                 1465                 1470             


Phe His  Gln Phe Asn Asn Ile  Ala Lys Leu Val Ala  Ser Asn Trp 
    1475                 1480                 1485             


Tyr Asn  Arg Gln Ile Glu Arg  Ser Ser Arg Thr Leu  Gly Cys Ser 
    1490                 1495                 1500             


Trp Glu  Phe Ile Pro Val Asp  Asp Gly Trp Gly Glu  Arg Pro Leu 
    1505                 1510                 1515             


Gly Ala  Gly Tyr Pro Tyr Asp  Val Pro Asp Tyr Ala  Gly Glu Asn 
    1520                 1525                 1530             


Leu Tyr  Phe Gln Gly Ala Gly  Trp Ser His Pro Gln  Phe Glu Lys 
    1535                 1540                 1545             


Gly Ala  Gly Trp Ser His Pro  Gln Phe Glu Lys Gly  Ala Gly Trp 
    1550                 1555                 1560             


Ser His  Pro Gln Phe Glu Lys  
    1565                 1570 


<210>  13
<211>  4804
<212>  DNA
<213>  Artificial

<220>
<223>  Propeptide fusion encoding sequence

<400>  13
ggatcccggt ccgttcgaac cagaactctg gaagcttaac tcctaaaaaa ccgccaccat       60

gaaattctta gtcaacgttg cccttgtttt tatggtcgta tacatttctt acatctatgc      120

ggccggacac caccaccacc accaccacca ccaccaccac gacgtcgaaa acctgtactt      180

ccaaggtgca gagcagaaac tcatcagcga agaagatttg ggagcaggcg cagcacaact      240

ccagctcgtt gagtccggtg gcggaatggt gcaacctggt ggctctttga ggctgtcatg      300

cgctgccagt ggattcacct tctcgactta cgacatgtcc tgggtgcgtc aggcacctgg      360

aaaaggtccc gaatgggtca gcatcattaa cgctggaggt ggcagcacat actacgcagc      420

gtctgttaag ggaaggttcg ctatctccag agacaacgcc aaaaacaccc tctacttgca      480

aatgaacaac ctgaagcccg aggatactgc tctctactac tgtgctcgcg tcgcctcata      540

ctactgccgt ggctacgttt gtagtcctcc cgagttcgac tactggggcc agggaacaca      600

agtgacggtc tccagcgaac caaagacacc aaaaccacag gctggtcagg gcgctcctgt      660

tccataccca gatccactgg aaccaagagg aacgcgtgga gcgggagcag gtccattcgt      720

caacaagcaa ttcaactaca aagatcctgt taacggtgtg gacatcgcct acatcaagat      780

tccgaacgca ggccagatgc aacctgtgaa ggctttcaaa atccacaaca agatctgggt      840

cattcccgag agagacacat tcacgaaccc agaggaaggt gatctgaacc ctcccccaga      900

agccaagcag gtgccggtct cttactacga ttcaacctac ctcagtactg acaacgagaa      960

ggataactac ctgaagggcg ttactaaact cttcgagcgc atctactcga cagacttggg     1020

ccgtatgctg ctcacgtcca tcgtcagggg tattcctttc tggggtggct caaccatcga     1080

cactgagctg aaggtcattg atacaaactg catcaacgtt attcaacccg acggctccta     1140

ccgcagcgag gaattgaacc tggtgatcat tggaccaagc gccgacatca ttcagttcga     1200

gtgtaagtct ttcggccatg aagtcctcaa cttgaccaga aacggctacg gctccactca     1260

atacatccgc ttcagccccg acttcacatt cggattcgag gaatcactgg aggtcgatac     1320

gaacccgttg ctgggtgctg gcaagttcgc caccgaccct gcagttactc tggcacacgc     1380

gctcatccac gcgggacatc gtctgtacgg tatcgctatt aacccaaaca gggtcttcaa     1440

ggttaacacc aacgcctact acgagatgag tggtctggaa gtgtcgttcg aggaactccg     1500

tacgttcgga ggtcacgacg caaagttcat cgatagtttg caggagaacg aattccgcct     1560

gtactactac aacaagttca aagacatcgc gtctacactc aacaaggcta aaagcattgt     1620

tggaaccact gctagtttgc aatacatgaa gaacgtgttc aaggagaaat acctcttgtc     1680

ggaagacacc tccggtaaat tcagcgtgga caagctgaaa ttcgataagt tgtacaaaat     1740

gctgacagaa atctacacgg aagacaactt cgttaagttc ttcaaagtgt tgaaccgtaa     1800

gaccgctctg aacttcgata aggctgtctt caaaatcaac attgtgccta aagtcaacta     1860

caccatctac gacggtttca acctccgcaa cactaacttg gctgccaact tcaacggcca     1920

gaacactgag atcaacaaca tgaacttcac aaagctcaaa aacttcaccg gtttgttcga     1980

gttctacaag ctgctctgcg tgcgtggtgg aggcacatct cacacgcaat ctgagaacct     2040

gtacttccaa ggtggtggcc agggtggagc tctgaacgat ctgtgtatca aggtgaataa     2100

ctgggatctg ttctttagcc caagcgagga taacttcacg aacgatctca acaaaggtga     2160

agagatcacg tctgatacca atatcgaagc ggctgaagag aatatctcct tggatctcat     2220

ccagcaatat tacctgacct ttaacttcga taacgagccc gaaaacatct ccatcgagaa     2280

cctcagctca gacatcattg gtcagttgga gctgatgcca aacattgaac gcttccccaa     2340

cggcaagaaa tacgaactcg acaagtatac gatgtttcat tacttaagag cgcaggagtt     2400

tgaacacggc aagagccgca ttgctctcac taactccgtg aatgaagccc tgctcaatcc     2460

gtcaagggtg tacacattct ttagctccga ctatgtcaag aaagtgaaca aagccaccga     2520

agcggcaatg ttcctgggat gggttgaaca actggtctac gacttcaccg acgagacctc     2580

tgaggtgagc acaacggaca agattgctga catcactatc attatcccgt atattggacc     2640

tgccttgaat attggcaaca tgctctacaa agacgatttc gttggtgccc tgatcttcag     2700

cggtgccgtg atcctgttgg agttcattcc tgaaatcgcc atccctgtgc tgggcacgtt     2760

cgctctggtc tcatacattg cgaataaggt cttgaccgtg cagacaatcg ataatgccct     2820

ctccaaacgt aacgaaaaat gggacgaggt ctacaaatac atcgtgacca actggctggc     2880

aaaggttaac acccaaattg atctgatccg taagaaaatg aaggaggctt tggagaacca     2940

ggctgaagct actaaagcca ttatcaacta ccagtataat cagtatacag aagaggaaaa     3000

gaataacatc aatttcaaca tcgatgactt gtcctcaaag ctgaacgagt ccatcaacaa     3060

agctatgatc aacatcaaca aattcctgaa tcagtgctcc gtgtcttacc tgatgaactc     3120

tatgatccca tacggtgtga agcgcctgga ggacttcgat gccagcctga aagacgcact     3180

gctcaaatac atttacgata atcgcggcac tttgattggc caagttgacc gtctgaagga     3240

caaggttaac aataccttgt caaccgatat ccccttccaa ctctctaagt acgtcgataa     3300

ccagcgcttg ctgagcacct tcacagaata catcaacaac atcatcaaca cctccatcct     3360

gaacctccgt tacgagtcta accacctcat cgacttgagc agatacgcta gcaagatcaa     3420

catcggttcc aaggtgaact tcgacccaat cgataagaac cagatccaac tgttcaacct     3480

cgaatcctct aagatcgaag tgatcctgaa gaacgctatc gtctacaact ccatgtacga     3540

aaacttctct accagcttct ggatcaggat tccgaaatac ttcaactcaa tctcgctcaa     3600

caacgagtac actatcatca actgcatgga aaacaactcg ggatggaagg tgtccctcaa     3660

ctacggcgag atcatctgga ctttgcagga cacacaagaa atcaagcaga gggtcgtgtt     3720

caagtacagc caaatgatca acatcagcga ttacatcaac cgttggatct tcgtcacaat     3780

caccaacaac cgcctgaaca actccaagat ttacatcaac ggtagactga tcgaccagaa     3840

gccaatcagc aacctcggca acatccacgc ctcaaacaac atcatgttca agttggacgg     3900

ctgtagggat acacacagat acatctggat caaatacttc aacctgttcg acaaggagct     3960

caacgagaag gaaatcaagg acctctacga taaccagtcc aactctggta tcttgaagga     4020

cttctggggc gattacctgc aatacgacaa gccctactac atgttgaacc tgtacgaccc     4080

taacaagtac gttgatgtga acaacgtcgg tatcaggggc tacatgtacc tgaagggacc     4140

acgtggttct gttatgacca ctaacatcta cctcaacagc tcattgtacc gtggcacaaa     4200

gttcatcatc aagaagtacg cctccggaaa caaggacaac atcgtccgta acaacgatcg     4260

cgtttacatc aacgttgtgg tcaagaacaa ggagtacaga ctggctacca acgcttcgca     4320

ggctggagtt gagaagatcc tgtctgctct ggaaatccct gacgtgggca acctctcaca     4380

ggttgtggtc atgaagtcga agaacgatca aggcatcact aacaagtgca agatgaactt     4440

gcaggacaac aacggaaacg acatcggctt catcggattc caccaattca acaacatcgc     4500

caagttggtg gccagcaact ggtacaaccg tcagatcgag cgttcgtccc gcaccttagg     4560

atgctcgtgg gagttcattc cagtcgatga cggatgggga gagagacctt tgggcgcagg     4620

atacccctac gatgtccctg actacgctgg agagaacctg tacttccagg gtgcaggatg     4680

gtcccaccca caattcgaga agggtgcagg atggagtcac ccacagttcg agaagggcgc     4740

tggatggtcc cacccacagt tcgagaaata attagttgat gcatagttaa ttagatagct     4800

cgag                                                                  4804


<210>  14
<211>  1570
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein

<400>  14

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ala Gly His His His His His His His His His 
            20                  25                  30          


His His Asp Val Glu Asn Leu Tyr Phe Gln Gly Ala Glu Gln Lys Leu 
        35                  40                  45              


Ile Ser Glu Glu Asp Leu Gly Ala Gly Ala Ala Gln Leu Gln Leu Val 
    50                  55                  60                  


Glu Ser Gly Gly Gly Met Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
65                  70                  75                  80  


Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr Asp Met Ser Trp Val 
                85                  90                  95      


Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Ile Ile Asn Ala 
            100                 105                 110         


Gly Gly Gly Ser Thr Tyr Tyr Ala Ala Ser Val Lys Gly Arg Phe Ala 
        115                 120                 125             


Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Asn 
    130                 135                 140                 


Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg Val Ala Ser 
145                 150                 155                 160 


Tyr Tyr Cys Arg Gly Tyr Val Cys Ser Pro Pro Glu Phe Asp Tyr Trp 
                165                 170                 175     


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys 
            180                 185                 190         


Pro Gln Ala Gly Gln Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu 
        195                 200                 205             


Pro Arg Gly Thr Arg Gly Ala Gly Ala Gly Pro Phe Val Asn Lys Gln 
    210                 215                 220                 


Phe Asn Tyr Lys Asp Pro Val Asn Gly Val Asp Ile Ala Tyr Ile Lys 
225                 230                 235                 240 


Ile Pro Asn Ala Gly Gln Met Gln Pro Val Lys Ala Phe Lys Ile His 
                245                 250                 255     


Asn Lys Ile Trp Val Ile Pro Glu Arg Asp Thr Phe Thr Asn Pro Glu 
            260                 265                 270         


Glu Gly Asp Leu Asn Pro Pro Pro Glu Ala Lys Gln Val Pro Val Ser 
        275                 280                 285             


Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr 
    290                 295                 300                 


Leu Lys Gly Val Thr Lys Leu Phe Glu Arg Ile Tyr Ser Thr Asp Leu 
305                 310                 315                 320 


Gly Arg Met Leu Leu Thr Ser Ile Val Arg Gly Ile Pro Phe Trp Gly 
                325                 330                 335     


Gly Ser Thr Ile Asp Thr Glu Leu Lys Val Ile Asp Thr Asn Cys Ile 
            340                 345                 350         


Asn Val Ile Gln Pro Asp Gly Ser Tyr Arg Ser Glu Glu Leu Asn Leu 
        355                 360                 365             


Val Ile Ile Gly Pro Ser Ala Asp Ile Ile Gln Phe Glu Cys Lys Ser 
    370                 375                 380                 


Phe Gly His Glu Val Leu Asn Leu Thr Arg Asn Gly Tyr Gly Ser Thr 
385                 390                 395                 400 


Gln Tyr Ile Arg Phe Ser Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser 
                405                 410                 415     


Leu Glu Val Asp Thr Asn Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr 
            420                 425                 430         


Asp Pro Ala Val Thr Leu Ala His Ala Leu Ile His Ala Gly His Arg 
        435                 440                 445             


Leu Tyr Gly Ile Ala Ile Asn Pro Asn Arg Val Phe Lys Val Asn Thr 
    450                 455                 460                 


Asn Ala Tyr Tyr Glu Met Ser Gly Leu Glu Val Ser Phe Glu Glu Leu 
465                 470                 475                 480 


Arg Thr Phe Gly Gly His Asp Ala Lys Phe Ile Asp Ser Leu Gln Glu 
                485                 490                 495     


Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn Lys Phe Lys Asp Ile Ala Ser 
            500                 505                 510         


Thr Leu Asn Lys Ala Lys Ser Ile Val Gly Thr Thr Ala Ser Leu Gln 
        515                 520                 525             


Tyr Met Lys Asn Val Phe Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr 
    530                 535                 540                 


Ser Gly Lys Phe Ser Val Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys 
545                 550                 555                 560 


Met Leu Thr Glu Ile Tyr Thr Glu Asp Asn Phe Val Lys Phe Phe Lys 
                565                 570                 575     


Val Leu Asn Arg Lys Thr Ala Leu Asn Phe Asp Lys Ala Val Phe Lys 
            580                 585                 590         


Ile Asn Ile Val Pro Lys Val Asn Tyr Thr Ile Tyr Asp Gly Phe Asn 
        595                 600                 605             


Leu Arg Asn Thr Asn Leu Ala Ala Asn Phe Asn Gly Gln Asn Thr Glu 
    610                 615                 620                 


Ile Asn Asn Met Asn Phe Thr Lys Leu Lys Asn Phe Thr Gly Leu Phe 
625                 630                 635                 640 


Glu Phe Tyr Lys Leu Leu Cys Val Arg Gly Gly Gly Thr Ser His Thr 
                645                 650                 655     


Gln Ser Glu Asn Leu Tyr Phe Gln Gly Gly Gly Gln Gly Gly Ala Leu 
            660                 665                 670         


Asn Asp Leu Cys Ile Lys Val Asn Asn Trp Asp Leu Phe Phe Ser Pro 
        675                 680                 685             


Ser Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu Ile Thr 
    690                 695                 700                 


Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu 
705                 710                 715                 720 


Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu Asn 
                725                 730                 735     


Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu 
            740                 745                 750         


Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu Leu Asp 
        755                 760                 765             


Lys Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu His Gly 
    770                 775                 780                 


Lys Ser Arg Ile Ala Leu Thr Asn Ser Val Asn Glu Ala Leu Leu Asn 
785                 790                 795                 800 


Pro Ser Arg Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys Lys Val 
                805                 810                 815     


Asn Lys Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu 
            820                 825                 830         


Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys 
        835                 840                 845             


Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn 
    850                 855                 860                 


Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu Ile Phe 
865                 870                 875                 880 


Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala Ile Pro 
                885                 890                 895     


Val Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys Val Leu 
            900                 905                 910         


Thr Val Gln Thr Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu Lys Trp 
        915                 920                 925             


Asp Glu Val Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys Val Asn 
    930                 935                 940                 


Thr Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu Glu Asn 
945                 950                 955                 960 


Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr 
                965                 970                 975     


Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser 
            980                 985                 990         


Ser Lys Leu Asn Glu Ser Ile Asn  Lys Ala Met Ile Asn  Ile Asn Lys 
        995                 1000                 1005             


Phe Leu  Asn Gln Cys Ser Val  Ser Tyr Leu Met Asn  Ser Met Ile 
    1010                 1015                 1020             


Pro Tyr  Gly Val Lys Arg Leu  Glu Asp Phe Asp Ala  Ser Leu Lys 
    1025                 1030                 1035             


Asp Ala  Leu Leu Lys Tyr Ile  Tyr Asp Asn Arg Gly  Thr Leu Ile 
    1040                 1045                 1050             


Gly Gln  Val Asp Arg Leu Lys  Asp Lys Val Asn Asn  Thr Leu Ser 
    1055                 1060                 1065             


Thr Asp  Ile Pro Phe Gln Leu  Ser Lys Tyr Val Asp  Asn Gln Arg 
    1070                 1075                 1080             


Leu Leu  Ser Thr Phe Thr Glu  Tyr Ile Asn Asn Ile  Ile Asn Thr 
    1085                 1090                 1095             


Ser Ile  Leu Asn Leu Arg Tyr  Glu Ser Asn His Leu  Ile Asp Leu 
    1100                 1105                 1110             


Ser Arg  Tyr Ala Ser Lys Ile  Asn Ile Gly Ser Lys  Val Asn Phe 
    1115                 1120                 1125             


Asp Pro  Ile Asp Lys Asn Gln  Ile Gln Leu Phe Asn  Leu Glu Ser 
    1130                 1135                 1140             


Ser Lys  Ile Glu Val Ile Leu  Lys Asn Ala Ile Val  Tyr Asn Ser 
    1145                 1150                 1155             


Met Tyr  Glu Asn Phe Ser Thr  Ser Phe Trp Ile Arg  Ile Pro Lys 
    1160                 1165                 1170             


Tyr Phe  Asn Ser Ile Ser Leu  Asn Asn Glu Tyr Thr  Ile Ile Asn 
    1175                 1180                 1185             


Cys Met  Glu Asn Asn Ser Gly  Trp Lys Val Ser Leu  Asn Tyr Gly 
    1190                 1195                 1200             


Glu Ile  Ile Trp Thr Leu Gln  Asp Thr Gln Glu Ile  Lys Gln Arg 
    1205                 1210                 1215             


Val Val  Phe Lys Tyr Ser Gln  Met Ile Asn Ile Ser  Asp Tyr Ile 
    1220                 1225                 1230             


Asn Arg  Trp Ile Phe Val Thr  Ile Thr Asn Asn Arg  Leu Asn Asn 
    1235                 1240                 1245             


Ser Lys  Ile Tyr Ile Asn Gly  Arg Leu Ile Asp Gln  Lys Pro Ile 
    1250                 1255                 1260             


Ser Asn  Leu Gly Asn Ile His  Ala Ser Asn Asn Ile  Met Phe Lys 
    1265                 1270                 1275             


Leu Asp  Gly Cys Arg Asp Thr  His Arg Tyr Ile Trp  Ile Lys Tyr 
    1280                 1285                 1290             


Phe Asn  Leu Phe Asp Lys Glu  Leu Asn Glu Lys Glu  Ile Lys Asp 
    1295                 1300                 1305             


Leu Tyr  Asp Asn Gln Ser Asn  Ser Gly Ile Leu Lys  Asp Phe Trp 
    1310                 1315                 1320             


Gly Asp  Tyr Leu Gln Tyr Asp  Lys Pro Tyr Tyr Met  Leu Asn Leu 
    1325                 1330                 1335             


Tyr Asp  Pro Asn Lys Tyr Val  Asp Val Asn Asn Val  Gly Ile Arg 
    1340                 1345                 1350             


Gly Tyr  Met Tyr Leu Lys Gly  Pro Arg Gly Ser Val  Met Thr Thr 
    1355                 1360                 1365             


Asn Ile  Tyr Leu Asn Ser Ser  Leu Tyr Arg Gly Thr  Lys Phe Ile 
    1370                 1375                 1380             


Ile Lys  Lys Tyr Ala Ser Gly  Asn Lys Asp Asn Ile  Val Arg Asn 
    1385                 1390                 1395             


Asn Asp  Arg Val Tyr Ile Asn  Val Val Val Lys Asn  Lys Glu Tyr 
    1400                 1405                 1410             


Arg Leu  Ala Thr Asn Ala Ser  Gln Ala Gly Val Glu  Lys Ile Leu 
    1415                 1420                 1425             


Ser Ala  Leu Glu Ile Pro Asp  Val Gly Asn Leu Ser  Gln Val Val 
    1430                 1435                 1440             


Val Met  Lys Ser Lys Asn Asp  Gln Gly Ile Thr Asn  Lys Cys Lys 
    1445                 1450                 1455             


Met Asn  Leu Gln Asp Asn Asn  Gly Asn Asp Ile Gly  Phe Ile Gly 
    1460                 1465                 1470             


Phe His  Gln Phe Asn Asn Ile  Ala Lys Leu Val Ala  Ser Asn Trp 
    1475                 1480                 1485             


Tyr Asn  Arg Gln Ile Glu Arg  Ser Ser Arg Thr Leu  Gly Cys Ser 
    1490                 1495                 1500             


Trp Glu  Phe Ile Pro Val Asp  Asp Gly Trp Gly Glu  Arg Pro Leu 
    1505                 1510                 1515             


Gly Ala  Gly Tyr Pro Tyr Asp  Val Pro Asp Tyr Ala  Gly Glu Asn 
    1520                 1525                 1530             


Leu Tyr  Phe Gln Gly Ala Gly  Trp Ser His Pro Gln  Phe Glu Lys 
    1535                 1540                 1545             


Gly Ala  Gly Trp Ser His Pro  Gln Phe Glu Lys Gly  Ala Gly Trp 
    1550                 1555                 1560             


Ser His  Pro Gln Phe Glu Lys  
    1565                 1570 


<210>  15
<211>  9028
<212>  DNA
<213>  Artificial

<220>
<223>  Propeptide fusion encoding sequence

<400>  15
gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc       60

gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc      120

acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt      180

agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg      240

ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt      300

ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta      360

taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt      420

aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt tcggggaaat      480

gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg      540

agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa      600

catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac      660

ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac      720

atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt      780

ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc      840

gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca      900

ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc      960

ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag     1020

gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa     1080

ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg     1140

gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa     1200

ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg     1260

gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt     1320

gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt     1380

caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag     1440

cattggtaac tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat     1500

ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct     1560

taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct     1620

tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca     1680

gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc     1740

agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc     1800

aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct     1860

gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag     1920

gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc     1980

tacaccgaac tgagatacct acagcgtgag cattgagaaa gcgccacgct tcccgaaggg     2040

agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag     2100

cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt     2160

gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac     2220

gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg     2280

ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc     2340

cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcctgatg     2400

cggtattttc tccttacgca tctgtgcggt atttcacacc gcagaccagc cgcgtaacct     2460

ggcaaaatcg gttacggttg agtaataaat ggatgccctg cgtaagcggg tgtgggcgga     2520

caataaagtc ttaaactgaa caaaatagat ctaaactatg acaataaagt cttaaactag     2580

acagaatagt tgtaaactga aatcagtcca gttatgctgt gaaaaagcat actggacttt     2640

tgttatggct aaagcaaact cttcattttc tgaagtgcaa attgcccgtc gtattaaaga     2700

ggggcgtggc caagggcatg gtaaagacta tattcgcggc gttgtgacaa tttaccgaac     2760

aactccgcgg ccgggaagcc gatctcggct tgaacgaatt gttaggtggc ggtacttggg     2820

tcgatatcaa agtgcatcac ttcttcccgt atgcccaact ttgtatagag agccactgcg     2880

ggatcgtcac cgtaatctgc ttgcacgtag atcacataag caccaagcgc gttggcctca     2940

tgcttgagga gattgatgag cgcggtggca atgccctgcc tccggtgctc gccggagact     3000

gcgagatcat agatatagat ctcactacgc ggctgctcaa acctgggcag aacgtaagcc     3060

gcgagagcgc caacaaccgc ttcttggtcg aaggcagcaa gcgcgatgaa tgtcttacta     3120

cggagcaagt tcccgaggta atcggagtcc ggctgatgtt gggagtaggt ggctacgtct     3180

ccgaactcac gaccgaaaag atcaagagca gcccgcatgg atttgacttg gtcagggccg     3240

agcctacatg tgcgaatgat gcccatactt gagccaccta actttgtttt agggcgactg     3300

ccctgctgcg taacatcgtt gctgctgcgt aacatcgttg ctgctccata acatcaaaca     3360

tcgacccacg gcgtaacgcg cttgctgctt ggatgcccga ggcatagact gtacaaaaaa     3420

acagtcataa caagccatga aaaccgccac tgcgccgtta ccaccgctgc gttcggtcaa     3480

ggttctggac cagttgcgtg agcgcatacg ctacttgcat tacagtttac gaaccgaaca     3540

ggcttatgtc aactgggttc gtgccttcat ccgtttccac ggtgtgcgtc acccggcaac     3600

cttgggcagc agcgaagtcg aggcatttct gtcctggctg gcgaacgagc gcaaggtttc     3660

ggtctccacg catcgtcagg cattggcggc cttgctgttc ttctacggca aggtgctgtg     3720

cacggatctg ccctggcttc aggagatcgg aagacctcgg ccgtcgcggc gcttgccggt     3780

ggtgctgacc ccggatgaag tggttcgcat cctcggtttt ctggaaggcg agcatcgttt     3840

gttcgcccag gactctagct atagttctag tggttggcta cgtatactcc ggaatattaa     3900

tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt     3960

ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca     4020

ccatcgggcg cggatcccgg tccgttcgaa ccagaactct ggaagcttaa ctcctaaaaa     4080

accgccacca tgaaattctt agtcaacgtt gcccttgttt ttatggtcgt atacatttct     4140

tacatctatg cggccggaca ccaccaccac caccaccacc accaccacca cgacgtctcg     4200

ggcttcgcta acgagctggg accacgcctg atgggaaaag gtgcaggatg ggaactccag     4260

caagccacgc gtggagcggg agcaggtcca ttcgtcaaca agcaattcaa ctacaaagat     4320

cctgttaacg gtgtggacat cgcctacatc aagattccga acgcaggcca gatgcaacct     4380

gtgaaggctt tcaaaatcca caacaagatc tgggtcattc ccgagagaga cacattcacg     4440

aacccagagg aaggtgatct gaaccctccc ccagaagcca agcaggtgcc ggtctcttac     4500

tacgattcaa cctacctcag tactgacaac gagaaggata actacctgaa gggcgttact     4560

aaactcttcg agcgcatcta ctcgacagac ttgggccgta tgctgctcac gtccatcgtc     4620

aggggtattc ctttctgggg tggctcaacc atcgacactg agctgaaggt cattgataca     4680

aactgcatca acgttattca acccgacggc tcctaccgca gcgaggaatt gaacctggtg     4740

atcattggac caagcgccga catcattcag ttcgagtgta agtctttcgg ccatgaagtc     4800

ctcaacttga ccagaaacgg ctacggctcc actcaataca tccgcttcag ccccgacttc     4860

acattcggat tcgaggaatc actggaggtc gatacgaacc cgttgctggg tgctggcaag     4920

ttcgccaccg accctgcagt tactctggca cacgcgctca tccacgcggg acatcgtctg     4980

tacggtatcg ctattaaccc aaacagggtc ttcaaggtta acaccaacgc ctactacgag     5040

atgagtggtc tggaagtgtc gttcgaggaa ctccgtacgt tcggaggtca cgacgcaaag     5100

ttcatcgata gtttgcagga gaacgaattc cgcctgtact actacaacaa gttcaaagac     5160

atcgcgtcta cactcaacaa ggctaaaagc attgttggaa ccactgctag tttgcaatac     5220

atgaagaacg tgttcaagga gaaatacctc ttgtcggaag acacctccgg taaattcagc     5280

gtggacaagc tgaaattcga taagttgtac aaaatgctga cagaaatcta cacggaagac     5340

aacttcgtta agttcttcaa agtgttgaac cgtaagaccg ctctgaactt cgataaggct     5400

gtcttcaaaa tcaacattgt gcctaaagtc aactacacca tctacgacgg tttcaacctc     5460

cgcaacacta acttggctgc caacttcaac ggccagaaca ctgagatcaa caacatgaac     5520

ttcacaaagc tcaaaaactt caccggtttg ttcgagttct acaagctgct ctgcgtgcgt     5580

ggtggaggca catctcacac gcaatctggc tgggaactcc agcaaggtgg ccagggtgga     5640

gctctgaacg atctgtgtat caaggtgaat aactgggatc tgttctttag cccaagcgag     5700

gataacttca cgaacgatct caacaaaggt gaagagatca cgtctgatac caatatcgaa     5760

gcggctgaag agaatatctc cttggatctc atccagcaat attacctgac ctttaacttc     5820

gataacgagc ccgaaaacat ctccatcgag aacctcagct cagacatcat tggtcagttg     5880

gagctgatgc caaacattga acgcttcccc aacggcaaga aatacgaact cgacaagtat     5940

acgatgtttc attacttaag agcgcaggag tttgaacacg gcaagagccg cattgctctc     6000

actaactccg tgaatgaagc cctgctcaat ccgtcaaggg tgtacacatt ctttagctcc     6060

gactatgtca agaaagtgaa caaagccacc gaagcggcaa tgttcctggg atgggttgaa     6120

caactggtct acgacttcac cgacgagacc tctgaggtga gcacaacgga caagattgct     6180

gacatcacta tcattatccc gtatattgga cctgccttga atattggcaa catgctctac     6240

aaagacgatt tcgttggtgc cctgatcttc agcggtgccg tgatcctgtt ggagttcatt     6300

cctgaaatcg ccatccctgt gctgggcacg ttcgctctgg tctcatacat tgcgaataar     6360

gtcttgaccg tgcagacaat cgataatgcc ctctccaaac gtaacgaaaa atgggacgag     6420

gtctacaaat acatcgtgac caactggctg gcaaaggtta acacccaaat tgatctgatc     6480

cgtaagaaaa tgaaggaggc tttggagaac caggctgaag ctactaaagc cattatcaac     6540

taccagtata atcagtatac agaagaggaa aagaataaca tcaatttcaa catcgatgac     6600

ttgtcctcaa agctgaacga gtccatcaac aaagctatga tcaacatcaa caaattcctg     6660

aatcagtgct ccgtgtctta cctgatgaac tctatgatcc catacggtgt gaagcgcctg     6720

gaggacttcg atgccagcct gaaagacgca ctgctcaaat acatttacga taatcgcggc     6780

actttgattg gccaagttga ccgtctgaag gacaaggtta acaatacctt gtcaaccgat     6840

atccccttcc aactctctaa gtacgtcgat aaccagcgct tgctgagcac cttcacagaa     6900

tacatcaaca acatcatcaa cacctccatc ctgaacctcc gttacgagtc taaccacctc     6960

atcgacttga gcagatacgc tagcaagatc aacatcggtt ccaaggtgaa cttcgaccca     7020

atcgataaga accagatcca actgttcaac ctcgaatcct ctaagatcga agtgatcctg     7080

aagaacgcta tcgtctacaa ctccatgtac gaaaacttct ctaccagctt ctggatcagg     7140

attccgaaat acttcaactc aatctcgctc aacaacgagt acactatcat caactgcatg     7200

gaaaacaact cgggatggaa ggtgtccctc aactacggcg agatcatctg gactttgcag     7260

gacacacaag aaatcaagca gagggtcgtg ttcaagtaca gccaaatgat caacatcagc     7320

gattacatca accgttggat cttcgtcaca atcaccaaca accgcctgaa caactccaag     7380

atttacatca acggtagact gatcgaccag aagccaatca gcaacctcgg caacatccac     7440

gcctcaaaca acatcatgtt caagttggac ggctgtaggg atacacacag atacatctgg     7500

atcaaatact tcaacctgtt cgacaaggag ctcaacgaga aggaaatcaa ggacctctac     7560

gataaccagt ccaactctgg tatcttgaag gacttctggg gcgattacct gcaatacgac     7620

aagccctact acatgttgaa cctgtacgac cctaacaagt acgttgatgt gaacaacgtc     7680

ggtatcaggg gctacatgta cctgaaggga ccacgtggtt ctgttatgac cactaacatc     7740

tacctcaaca gctcattgta ccgtggcaca aagttcatca tcaagaagta cgcctccgga     7800

aacaaggaca acatcgtccg taacaacgat cgcgtttaca tcaacgttgt ggtcaagaac     7860

aaggagtaca gactggctac caacgcttcg caggctggag ttgagaagat cctgtctgct     7920

ctggaaatcc ctgacgtggg caacctctca caggttgtgg tcatgaagtc gaagaacgat     7980

caaggcatca ctaacaagtg caagatgaac ttgcaggaca acaacggaaa cgacatcggc     8040

ttcatcggat tccaccaatt caacaacatc gccaagttgg tggccagcaa ctggtacaac     8100

cgtcagatcg agcgttcgtc ccgcacctta ggatgctcgt gggagttcat tccagtcgat     8160

gacggatggg gagagagacc tttgggcgca ggaggatggg aactccagca aggttacccc     8220

tacgatgtcc ctgactacgc tggtgcagga tggtcccacc cacaattcga gaagggtgca     8280

ggatggagtc acccacagtt cgagaagggc gctggatggt cccacccaca gttcgagaaa     8340

taattagttg atgcatagtt aattagatag ctcgaggcat gcggtaccaa gcttgtcgag     8400

aagtactaga ggatcataat cagccatacc acatttgtag aggttttact tgctttaaaa     8460

aacctcccac acctccccct gaacctgaaa cataaaatga atgcaattgt tgttgttaac     8520

ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat     8580

aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat     8640

catgtctgga tctgatcact gcttgagcct aggagatccg aaccagataa gtgaaatcta     8700

gttccaaact attttgtcat ttttaatttt cgtattagct tacgacgcta cacccagttc     8760

ccatctattt tgtcactctt ccctaaataa tccttaaaaa ctccatttcc acccctccca     8820

gttcccaact attttgtccg cccacagcgg ggcatttttc ttcctgttat gtttttaatc     8880

aaacatcctg ccaactccat gtgacaaacc gtcatcttcg gctacttttt ctctgtcaca     8940

gaatgaaaat ttttctgtca tctcttcgtt attaatgttt gtaattgact gaatatcaac     9000

gcttatttgc agcctgaatg gcgaatgg                                        9028


<210>  16
<211>  1417
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein

<400>  16

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ala Gly His His His His His His His His His 
            20                  25                  30          


His His Asp Val Ser Gly Phe Ala Asn Glu Leu Gly Pro Arg Leu Met 
        35                  40                  45              


Gly Lys Gly Ala Gly Trp Glu Leu Gln Gln Ala Thr Arg Gly Ala Gly 
    50                  55                  60                  


Ala Gly Pro Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val Asn 
65                  70                  75                  80  


Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met Gln 
                85                  90                  95      


Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro Glu 
            100                 105                 110         


Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro Pro 
        115                 120                 125             


Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser 
    130                 135                 140                 


Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu Phe 
145                 150                 155                 160 


Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr Ser Ile 
                165                 170                 175     


Val Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu 
            180                 185                 190         


Lys Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly Ser 
        195                 200                 205             


Tyr Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala Asp 
    210                 215                 220                 


Ile Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn Leu 
225                 230                 235                 240 


Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro Asp 
                245                 250                 255     


Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro Leu 
            260                 265                 270         


Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala His 
        275                 280                 285             


Ala Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala Ile Asn Pro 
    290                 295                 300                 


Asn Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser Gly 
305                 310                 315                 320 


Leu Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp Ala 
                325                 330                 335     


Lys Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr 
            340                 345                 350         


Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser Ile 
        355                 360                 365             


Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys Glu 
    370                 375                 380                 


Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp Lys 
385                 390                 395                 400 


Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr Thr Glu 
                405                 410                 415     


Asp Asn Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys Thr Ala Leu 
            420                 425                 430         


Asn Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val Asn 
        435                 440                 445             


Tyr Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala Ala 
    450                 455                 460                 


Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr Lys 
465                 470                 475                 480 


Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys Val 
                485                 490                 495     


Arg Gly Gly Gly Thr Ser His Thr Gln Ser Gly Trp Glu Leu Gln Gln 
            500                 505                 510         


Gly Gly Gln Gly Gly Ala Leu Asn Asp Leu Cys Ile Lys Val Asn Asn 
        515                 520                 525             


Trp Asp Leu Phe Phe Ser Pro Ser Glu Asp Asn Phe Thr Asn Asp Leu 
    530                 535                 540                 


Asn Lys Gly Glu Glu Ile Thr Ser Asp Thr Asn Ile Glu Ala Ala Glu 
545                 550                 555                 560 


Glu Asn Ile Ser Leu Asp Leu Ile Gln Gln Tyr Tyr Leu Thr Phe Asn 
                565                 570                 575     


Phe Asp Asn Glu Pro Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp 
            580                 585                 590         


Ile Ile Gly Gln Leu Glu Leu Met Pro Asn Ile Glu Arg Phe Pro Asn 
        595                 600                 605             


Gly Lys Lys Tyr Glu Leu Asp Lys Tyr Thr Met Phe His Tyr Leu Arg 
    610                 615                 620                 


Ala Gln Glu Phe Glu His Gly Lys Ser Arg Ile Ala Leu Thr Asn Ser 
625                 630                 635                 640 


Val Asn Glu Ala Leu Leu Asn Pro Ser Arg Val Tyr Thr Phe Phe Ser 
                645                 650                 655     


Ser Asp Tyr Val Lys Lys Val Asn Lys Ala Thr Glu Ala Ala Met Phe 
            660                 665                 670         


Leu Gly Trp Val Glu Gln Leu Val Tyr Asp Phe Thr Asp Glu Thr Ser 
        675                 680                 685             


Glu Val Ser Thr Thr Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro 
    690                 695                 700                 


Tyr Ile Gly Pro Ala Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp 
705                 710                 715                 720 


Phe Val Gly Ala Leu Ile Phe Ser Gly Ala Val Ile Leu Leu Glu Phe 
                725                 730                 735     


Ile Pro Glu Ile Ala Ile Pro Val Leu Gly Thr Phe Ala Leu Val Ser 
            740                 745                 750         


Tyr Ile Ala Asn Lys Val Leu Thr Val Gln Thr Ile Asp Asn Ala Leu 
        755                 760                 765             


Ser Lys Arg Asn Glu Lys Trp Asp Glu Val Tyr Lys Tyr Ile Val Thr 
    770                 775                 780                 


Asn Trp Leu Ala Lys Val Asn Thr Gln Ile Asp Leu Ile Arg Lys Lys 
785                 790                 795                 800 


Met Lys Glu Ala Leu Glu Asn Gln Ala Glu Ala Thr Lys Ala Ile Ile 
                805                 810                 815     


Asn Tyr Gln Tyr Asn Gln Tyr Thr Glu Glu Glu Lys Asn Asn Ile Asn 
            820                 825                 830         


Phe Asn Ile Asp Asp Leu Ser Ser Lys Leu Asn Glu Ser Ile Asn Lys 
        835                 840                 845             


Ala Met Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys Ser Val Ser Tyr 
    850                 855                 860                 


Leu Met Asn Ser Met Ile Pro Tyr Gly Val Lys Arg Leu Glu Asp Phe 
865                 870                 875                 880 


Asp Ala Ser Leu Lys Asp Ala Leu Leu Lys Tyr Ile Tyr Asp Asn Arg 
                885                 890                 895     


Gly Thr Leu Ile Gly Gln Val Asp Arg Leu Lys Asp Lys Val Asn Asn 
            900                 905                 910         


Thr Leu Ser Thr Asp Ile Pro Phe Gln Leu Ser Lys Tyr Val Asp Asn 
        915                 920                 925             


Gln Arg Leu Leu Ser Thr Phe Thr Glu Tyr Ile Asn Asn Ile Ile Asn 
    930                 935                 940                 


Thr Ser Ile Leu Asn Leu Arg Tyr Glu Ser Asn His Leu Ile Asp Leu 
945                 950                 955                 960 


Ser Arg Tyr Ala Ser Lys Ile Asn Ile Gly Ser Lys Val Asn Phe Asp 
                965                 970                 975     


Pro Ile Asp Lys Asn Gln Ile Gln Leu Phe Asn Leu Glu Ser Ser Lys 
            980                 985                 990         


Ile Glu Val Ile Leu Lys Asn Ala  Ile Val Tyr Asn Ser  Met Tyr Glu 
        995                 1000                 1005             


Asn Phe  Ser Thr Ser Phe Trp  Ile Arg Ile Pro Lys  Tyr Phe Asn 
    1010                 1015                 1020             


Ser Ile  Ser Leu Asn Asn Glu  Tyr Thr Ile Ile Asn  Cys Met Glu 
    1025                 1030                 1035             


Asn Asn  Ser Gly Trp Lys Val  Ser Leu Asn Tyr Gly  Glu Ile Ile 
    1040                 1045                 1050             


Trp Thr  Leu Gln Asp Thr Gln  Glu Ile Lys Gln Arg  Val Val Phe 
    1055                 1060                 1065             


Lys Tyr  Ser Gln Met Ile Asn  Ile Ser Asp Tyr Ile  Asn Arg Trp 
    1070                 1075                 1080             


Ile Phe  Val Thr Ile Thr Asn  Asn Arg Leu Asn Asn  Ser Lys Ile 
    1085                 1090                 1095             


Tyr Ile  Asn Gly Arg Leu Ile  Asp Gln Lys Pro Ile  Ser Asn Leu 
    1100                 1105                 1110             


Gly Asn  Ile His Ala Ser Asn  Asn Ile Met Phe Lys  Leu Asp Gly 
    1115                 1120                 1125             


Cys Arg  Asp Thr His Arg Tyr  Ile Trp Ile Lys Tyr  Phe Asn Leu 
    1130                 1135                 1140             


Phe Asp  Lys Glu Leu Asn Glu  Lys Glu Ile Lys Asp  Leu Tyr Asp 
    1145                 1150                 1155             


Asn Gln  Ser Asn Ser Gly Ile  Leu Lys Asp Phe Trp  Gly Asp Tyr 
    1160                 1165                 1170             


Leu Gln  Tyr Asp Lys Pro Tyr  Tyr Met Leu Asn Leu  Tyr Asp Pro 
    1175                 1180                 1185             


Asn Lys  Tyr Val Asp Val Asn  Asn Val Gly Ile Arg  Gly Tyr Met 
    1190                 1195                 1200             


Tyr Leu  Lys Gly Pro Arg Gly  Ser Val Met Thr Thr  Asn Ile Tyr 
    1205                 1210                 1215             


Leu Asn  Ser Ser Leu Tyr Arg  Gly Thr Lys Phe Ile  Ile Lys Lys 
    1220                 1225                 1230             


Tyr Ala  Ser Gly Asn Lys Asp  Asn Ile Val Arg Asn  Asn Asp Arg 
    1235                 1240                 1245             


Val Tyr  Ile Asn Val Val Val  Lys Asn Lys Glu Tyr  Arg Leu Ala 
    1250                 1255                 1260             


Thr Asn  Ala Ser Gln Ala Gly  Val Glu Lys Ile Leu  Ser Ala Leu 
    1265                 1270                 1275             


Glu Ile  Pro Asp Val Gly Asn  Leu Ser Gln Val Val  Val Met Lys 
    1280                 1285                 1290             


Ser Lys  Asn Asp Gln Gly Ile  Thr Asn Lys Cys Lys  Met Asn Leu 
    1295                 1300                 1305             


Gln Asp  Asn Asn Gly Asn Asp  Ile Gly Phe Ile Gly  Phe His Gln 
    1310                 1315                 1320             


Phe Asn  Asn Ile Ala Lys Leu  Val Ala Ser Asn Trp  Tyr Asn Arg 
    1325                 1330                 1335             


Gln Ile  Glu Arg Ser Ser Arg  Thr Leu Gly Cys Ser  Trp Glu Phe 
    1340                 1345                 1350             


Ile Pro  Val Asp Asp Gly Trp  Gly Glu Arg Pro Leu  Gly Ala Gly 
    1355                 1360                 1365             


Gly Trp  Glu Leu Gln Gln Gly  Tyr Pro Tyr Asp Val  Pro Asp Tyr 
    1370                 1375                 1380             


Ala Gly  Ala Gly Trp Ser His  Pro Gln Phe Glu Lys  Gly Ala Gly 
    1385                 1390                 1395             


Trp Ser  His Pro Gln Phe Glu  Lys Gly Ala Gly Trp  Ser His Pro 
    1400                 1405                 1410             


Gln Phe  Glu Lys 
    1415         


<210>  17
<211>  9092
<212>  DNA
<213>  Artificial

<220>
<223>  Propeptide fusion encoding sequence

<400>  17
gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc       60

gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc      120

acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt      180

agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg      240

ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt      300

ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta      360

taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt      420

aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt tcggggaaat      480

gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg      540

agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa      600

catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac      660

ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac      720

atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt      780

ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc      840

gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca      900

ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc      960

ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag     1020

gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa     1080

ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg     1140

gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa     1200

ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg     1260

gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt     1320

gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt     1380

caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag     1440

cattggtaac tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat     1500

ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct     1560

taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct     1620

tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca     1680

gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc     1740

agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc     1800

aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct     1860

gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag     1920

gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc     1980

tacaccgaac tgagatacct acagcgtgag cattgagaaa gcgccacgct tcccgaaggg     2040

agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag     2100

cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt     2160

gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac     2220

gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg     2280

ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc     2340

cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcctgatg     2400

cggtattttc tccttacgca tctgtgcggt atttcacacc gcagaccagc cgcgtaacct     2460

ggcaaaatcg gttacggttg agtaataaat ggatgccctg cgtaagcggg tgtgggcgga     2520

caataaagtc ttaaactgaa caaaatagat ctaaactatg acaataaagt cttaaactag     2580

acagaatagt tgtaaactga aatcagtcca gttatgctgt gaaaaagcat actggacttt     2640

tgttatggct aaagcaaact cttcattttc tgaagtgcaa attgcccgtc gtattaaaga     2700

ggggcgtggc caagggcatg gtaaagacta tattcgcggc gttgtgacaa tttaccgaac     2760

aactccgcgg ccgggaagcc gatctcggct tgaacgaatt gttaggtggc ggtacttggg     2820

tcgatatcaa agtgcatcac ttcttcccgt atgcccaact ttgtatagag agccactgcg     2880

ggatcgtcac cgtaatctgc ttgcacgtag atcacataag caccaagcgc gttggcctca     2940

tgcttgagga gattgatgag cgcggtggca atgccctgcc tccggtgctc gccggagact     3000

gcgagatcat agatatagat ctcactacgc ggctgctcaa acctgggcag aacgtaagcc     3060

gcgagagcgc caacaaccgc ttcttggtcg aaggcagcaa gcgcgatgaa tgtcttacta     3120

cggagcaagt tcccgaggta atcggagtcc ggctgatgtt gggagtaggt ggctacgtct     3180

ccgaactcac gaccgaaaag atcaagagca gcccgcatgg atttgacttg gtcagggccg     3240

agcctacatg tgcgaatgat gcccatactt gagccaccta actttgtttt agggcgactg     3300

ccctgctgcg taacatcgtt gctgctgcgt aacatcgttg ctgctccata acatcaaaca     3360

tcgacccacg gcgtaacgcg cttgctgctt ggatgcccga ggcatagact gtacaaaaaa     3420

acagtcataa caagccatga aaaccgccac tgcgccgtta ccaccgctgc gttcggtcaa     3480

ggttctggac cagttgcgtg agcgcatacg ctacttgcat tacagtttac gaaccgaaca     3540

ggcttatgtc aactgggttc gtgccttcat ccgtttccac ggtgtgcgtc acccggcaac     3600

cttgggcagc agcgaagtcg aggcatttct gtcctggctg gcgaacgagc gcaaggtttc     3660

ggtctccacg catcgtcagg cattggcggc cttgctgttc ttctacggca aggtgctgtg     3720

cacggatctg ccctggcttc aggagatcgg aagacctcgg ccgtcgcggc gcttgccggt     3780

ggtgctgacc ccggatgaag tggttcgcat cctcggtttt ctggaaggcg agcatcgttt     3840

gttcgcccag gactctagct atagttctag tggttggcta cgtatactcc ggaatattaa     3900

tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt     3960

ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca     4020

ccatcgggcg cggatcccgg tccgttcgaa ccagaactct ggaagcttaa ctcctaaaaa     4080

accgccacca tgaaattctt agtcaacgtt gcccttgttt ttatggtcgt atacatttct     4140

tacatctatg cggccggaca ccaccaccac caccaccacc accaccacca cgacgtctcg     4200

ggcttcgcta acgagctggg accacgcctg atgggaaaag gtgcaggatg ggaactccag     4260

caagccacgc gtggagcggg agctggaccg atcaccatca acaacttcaa ttacagcgac     4320

ccggtggata acaagaacat cctctacttg gacacacact tgaacacgct ggctaacgag     4380

cctgaaaaag ctttcaggat caccggcaac atttgggtca ttccggatag gttcagcaga     4440

aactctaacc ctaacttgaa caaacctccc agagtgacct cacctaagag tggatactac     4500

gaccccaact acctctcgac tgactccgat aaagacccct tcctgaagga gatcattaaa     4560

ctcttcaagc gcatcaactc tcgtgaaatt ggcgaggaat tgatctaccg cctgagtaca     4620

gacatcccat tcccgggtaa caacaacacc ccaatcaaca ctttcgattt cgatgtcgat     4680

ttcaactcag tggatgtcaa aaccaggcag ggaaacaact gggtgaagac tggtagcatc     4740

aacccatctg tcatcattac tggcccgaga gagaacatca ttgaccctga aacctccact     4800

ttcaagctga caaacaacac gttcgctgct caggaaggct tcggagcgtt gagcatcatt     4860

tctatctcac ctcgcttcat gctgacatac tctaacgcta cgaacgacgt gggagagggc     4920

cgtttcagta agtctgaatt ctgcatggac cctattctga tcctcatgca cgctctcaac     4980

ggcgccatgc acaacttgta cggaattgct atccccaacg accagaccat ttccagcgtg     5040

actagcaaca tcttctactc tcaatacaac gtcaagctgg agtacgcaga aatctacgct     5100

ttcggtggcc caaccattga cttgatcccg aaatcagctc gtaagtattt cgaagaaaaa     5160

gcgctggatt attacaggtc gattgctaag agactcaact ccatcaccac tgctaacccc     5220

tcttcattca acaagtacat tggagaatac aagcagaaac tgatccgcaa gtaccgtttc     5280

gtggtcgaga gttcgggtga agttactgtg aaccgcaaca agttcgtcga gctgtacaac     5340

gaattgacac aaatcttcac ggagttcaac tacgccaaaa tttacaacgt gcaaaaccgt     5400

aagatcgcgc tctctaacgt ctacaccccg gttaccgcta acatcttgga cgataacgtc     5460

tacgacattc agaacggttt caacatccca aagtcgaacc tcaacgtttt gttcatgggt     5520

caaaacttgt cccgcaaccc cgccctgcgt aaggtgaacc cagagaacat gttgtacctg     5580

ttcaccaaat tctgccacaa ggccatcgac ggtcagtctc tagaccaagg aggatgggaa     5640

ctccagcaag gtggccaggg tggaggtgct ggcaccctgg actgtcgcga actgctcgtt     5700

aagaacactg atctcccatt cattggcgac atctctgatg tgaaaacaga cattttcctg     5760

cgtaaggata tcaacgagga aacggaggtc atctactacc ctgacaacgt ctcggttgat     5820

caggttatct tgtcaaagaa caccagtgaa catggccaac tggacttgct gtacccctca     5880

attgattccg agagcgaaat cctgccagga gagaaccagg ttttctacga caacaggaca     5940

caaaacgtgg attacctcaa cagctactac tacctggagt cgcagaagct ctccgacaac     6000

gtcgaagatt tcacatttac gagatcaatc gaggaggctt tggacaacag tgccaaagtc     6060

tacacctact tccctactct ggcaaacaag gtgaacgcgg gtgtccaagg cggactcttc     6120

ttgatgtggg ctaacgacgt tgtggaagat ttcacaacga acatcttgcg caaagacacc     6180

ctggataaga tcagcgatgt ctctgccatc attccataca ttggcccggc actgaacatc     6240

tctaactcag ttcgccgtgg caacttcact gaggcattcg cggtcacagg agttacgatc     6300

ctcttggagg ctttcccgga gttcacaatc cccgcactgg gcgcgttcgt tatctactcc     6360

aaagtgcagg agcgcaacga aatcattaag actatcgaca actgcctgga gcaaaggatc     6420

aaaagatgga aggattcgta cgaatggatg atgggtacct ggctctcccg tatcattacg     6480

cagttcaaca acatcagcta ccaaatgtac gactctctca actaccaggc tggtgccatc     6540

aaggccaaaa ttgacttgga gtacaagaaa tacagtggct cggataaaga gaacatcaag     6600

agtcaagtcg aaaacctgaa aaactcactc gacgttaaga tcagtgaggc aatgaacaac     6660

atcaacaagt tcattcgcga atgttccgtt acctacctct tcaaaaacat gttgccaaag     6720

gtcatcgacg agctgaacga atttgatcgt aacactaagg cgaaactgat taacctcatc     6780

gactcacaca acatcatttt ggtgggcgaa gtcgataagc tgaaagccaa ggtgaacaac     6840

agtttccaga acacaatccc tttcaacatt ttctcataca cgaacaacag tctgctcaag     6900

gacatcatta acgagtactt caacaacatt aacgatagca aaatcctgtc actgcagaac     6960

cgtaagaaca cactggtcga tactagtgga tacaacgccg aagtctctga ggaaggtgac     7020

gtgcagctga accctatctt ccccttcgac ttcaaattgg gctccagcgg agaggatagg     7080

ggcaaggtca tcgtcaccca gaacgagaac atcgtctaca actcaatgta cgaatccttc     7140

agcatctctt tctggatcag gattaacaag tgggtgagca acctgcccgg ttacacaatc     7200

attgactctg tcaagaacaa ctcaggttgg agtatcggca tcatttctaa cttcttggtc     7260

ttcaccctga agcagaacga ggactcggaa caatccatta acttctcata cgatatcagt     7320

aacaacgctc caggttacaa caagtggttc ttcgttaccg tgactaacaa catgatgggt     7380

aacatgaaaa tttacatcaa cggcaagctc attgacacca tcaaagtgaa ggagttgact     7440

ggtattaact tctccaaaac aatcacgttt gaaattaaca agatccctga caccggcctg     7500

atcacttcag acagtgataa catcaacatg tggattaggg atttctacat cttcgccaag     7560

gagctcgacg gaaaggatat taacatcctc ttcaacagct tgcagtacac caacgtcgtt     7620

aaagactact ggggtaacga tttgagatac aacaaggagt actacatggt caacatcgac     7680

tacctgaaca ggtacatgta cgctaactcc cgccaaatcg tgttcaacac caggagaaac     7740

aacaacgact tcaacgaggg ttacaaaatc attatcaagc gcatccgtgg caacaccaac     7800

gatactaggg tgagaggtgg cgacattctg tacttcgata tgactatcaa caacaaagcc     7860

tacaacttgt tcatgaaaaa cgagacaatg tacgccgaca accatagcac ggaggatatt     7920

tacgcaatcg gactgaggga acagacaaag gacatcaacg ataacattat cttccagatc     7980

caacctatga acaacacgta ctactacgct tcgcaaatct tcaagtccaa cttcaacgga     8040

gaaaacattt cgggtatctg ttccattggc acataccgct tccgtctggg tggtgactgg     8100

tatcgtcaca actacctcgt tcccaccgtg aagcagggta actacgcttc tttgctggag     8160

tcgacttcca cgcactgggg attcgttcct gtgtcagagg gcgctggcta cccttacgat     8220

gttcccgact acgctggttg ggaactccag caaggtgcag gatggtccca ccctcaattc     8280

gagaagggtg ccggatggag tcacccacag ttcgagaaag gcgctggatg gagtcaccca     8340

cagttcgaga aataattagt tgatgcatag ttaattagat agctcgaggc atgcggtacc     8400

aagattggat ctagatgcat agttaattag atagctcgag gcatgcggta ccaagcttgt     8460

cgagaagtac tagaggatca taatcagcca taccacattt gtagaggttt tacttgcttt     8520

aaaaaacctc ccacacctcc ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt     8580

taacttgttt attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac     8640

aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc     8700

ttatcatgtc tggatctgat cactgcttga gcctaggaga tccgaaccag ataagtgaaa     8760

tctagttcca aactattttg tcatttttaa ttttcgtatt agcttacgac gctacaccca     8820

gttcccatct attttgtcac tcttccctaa ataatcctta aaaactccat ttccacccct     8880

cccagttccc aactattttg tccgcccaca gcggggcatt tttcttcctg ttatgttttt     8940

aatcaaacat cctgccaact ccatgtgaca aaccgtcatc ttcggctact ttttctctgt     9000

cacagaatga aaatttttct gtcatctctt cgttattaat gtttgtaatt gactgaatat     9060

caacgcttat ttgcagcctg aatggcgaat gg                                   9092


<210>  18
<211>  1421
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein

<400>  18

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ala Gly His His His His His His His His His 
            20                  25                  30          


His His Asp Val Ser Gly Phe Ala Asn Glu Leu Gly Pro Arg Leu Met 
        35                  40                  45              


Gly Lys Gly Ala Gly Trp Glu Leu Gln Gln Ala Thr Arg Gly Ala Gly 
    50                  55                  60                  


Ala Gly Pro Ile Thr Ile Asn Asn Phe Asn Tyr Ser Asp Pro Val Asp 
65                  70                  75                  80  


Asn Lys Asn Ile Leu Tyr Leu Asp Thr His Leu Asn Thr Leu Ala Asn 
                85                  90                  95      


Glu Pro Glu Lys Ala Phe Arg Ile Thr Gly Asn Ile Trp Val Ile Pro 
            100                 105                 110         


Asp Arg Phe Ser Arg Asn Ser Asn Pro Asn Leu Asn Lys Pro Pro Arg 
        115                 120                 125             


Val Thr Ser Pro Lys Ser Gly Tyr Tyr Asp Pro Asn Tyr Leu Ser Thr 
    130                 135                 140                 


Asp Ser Asp Lys Asp Pro Phe Leu Lys Glu Ile Ile Lys Leu Phe Lys 
145                 150                 155                 160 


Arg Ile Asn Ser Arg Glu Ile Gly Glu Glu Leu Ile Tyr Arg Leu Ser 
                165                 170                 175     


Thr Asp Ile Pro Phe Pro Gly Asn Asn Asn Thr Pro Ile Asn Thr Phe 
            180                 185                 190         


Asp Phe Asp Val Asp Phe Asn Ser Val Asp Val Lys Thr Arg Gln Gly 
        195                 200                 205             


Asn Asn Trp Val Lys Thr Gly Ser Ile Asn Pro Ser Val Ile Ile Thr 
    210                 215                 220                 


Gly Pro Arg Glu Asn Ile Ile Asp Pro Glu Thr Ser Thr Phe Lys Leu 
225                 230                 235                 240 


Thr Asn Asn Thr Phe Ala Ala Gln Glu Gly Phe Gly Ala Leu Ser Ile 
                245                 250                 255     


Ile Ser Ile Ser Pro Arg Phe Met Leu Thr Tyr Ser Asn Ala Thr Asn 
            260                 265                 270         


Asp Val Gly Glu Gly Arg Phe Ser Lys Ser Glu Phe Cys Met Asp Pro 
        275                 280                 285             


Ile Leu Ile Leu Met His Ala Leu Asn Gly Ala Met His Asn Leu Tyr 
    290                 295                 300                 


Gly Ile Ala Ile Pro Asn Asp Gln Thr Ile Ser Ser Val Thr Ser Asn 
305                 310                 315                 320 


Ile Phe Tyr Ser Gln Tyr Asn Val Lys Leu Glu Tyr Ala Glu Ile Tyr 
                325                 330                 335     


Ala Phe Gly Gly Pro Thr Ile Asp Leu Ile Pro Lys Ser Ala Arg Lys 
            340                 345                 350         


Tyr Phe Glu Glu Lys Ala Leu Asp Tyr Tyr Arg Ser Ile Ala Lys Arg 
        355                 360                 365             


Leu Asn Ser Ile Thr Thr Ala Asn Pro Ser Ser Phe Asn Lys Tyr Ile 
    370                 375                 380                 


Gly Glu Tyr Lys Gln Lys Leu Ile Arg Lys Tyr Arg Phe Val Val Glu 
385                 390                 395                 400 


Ser Ser Gly Glu Val Thr Val Asn Arg Asn Lys Phe Val Glu Leu Tyr 
                405                 410                 415     


Asn Glu Leu Thr Gln Ile Phe Thr Glu Phe Asn Tyr Ala Lys Ile Tyr 
            420                 425                 430         


Asn Val Gln Asn Arg Lys Ile Ala Leu Ser Asn Val Tyr Thr Pro Val 
        435                 440                 445             


Thr Ala Asn Ile Leu Asp Asp Asn Val Tyr Asp Ile Gln Asn Gly Phe 
    450                 455                 460                 


Asn Ile Pro Lys Ser Asn Leu Asn Val Leu Phe Met Gly Gln Asn Leu 
465                 470                 475                 480 


Ser Arg Asn Pro Ala Leu Arg Lys Val Asn Pro Glu Asn Met Leu Tyr 
                485                 490                 495     


Leu Phe Thr Lys Phe Cys His Lys Ala Ile Asp Gly Gln Ser Leu Asp 
            500                 505                 510         


Gln Gly Gly Trp Glu Leu Gln Gln Gly Gly Gln Gly Gly Gly Ala Gly 
        515                 520                 525             


Thr Leu Asp Cys Arg Glu Leu Leu Val Lys Asn Thr Asp Leu Pro Phe 
    530                 535                 540                 


Ile Gly Asp Ile Ser Asp Val Lys Thr Asp Ile Phe Leu Arg Lys Asp 
545                 550                 555                 560 


Ile Asn Glu Glu Thr Glu Val Ile Tyr Tyr Pro Asp Asn Val Ser Val 
                565                 570                 575     


Asp Gln Val Ile Leu Ser Lys Asn Thr Ser Glu His Gly Gln Leu Asp 
            580                 585                 590         


Leu Leu Tyr Pro Ser Ile Asp Ser Glu Ser Glu Ile Leu Pro Gly Glu 
        595                 600                 605             


Asn Gln Val Phe Tyr Asp Asn Arg Thr Gln Asn Val Asp Tyr Leu Asn 
    610                 615                 620                 


Ser Tyr Tyr Tyr Leu Glu Ser Gln Lys Leu Ser Asp Asn Val Glu Asp 
625                 630                 635                 640 


Phe Thr Phe Thr Arg Ser Ile Glu Glu Ala Leu Asp Asn Ser Ala Lys 
                645                 650                 655     


Val Tyr Thr Tyr Phe Pro Thr Leu Ala Asn Lys Val Asn Ala Gly Val 
            660                 665                 670         


Gln Gly Gly Leu Phe Leu Met Trp Ala Asn Asp Val Val Glu Asp Phe 
        675                 680                 685             


Thr Thr Asn Ile Leu Arg Lys Asp Thr Leu Asp Lys Ile Ser Asp Val 
    690                 695                 700                 


Ser Ala Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile Ser Asn Ser 
705                 710                 715                 720 


Val Arg Arg Gly Asn Phe Thr Glu Ala Phe Ala Val Thr Gly Val Thr 
                725                 730                 735     


Ile Leu Leu Glu Ala Phe Pro Glu Phe Thr Ile Pro Ala Leu Gly Ala 
            740                 745                 750         


Phe Val Ile Tyr Ser Lys Val Gln Glu Arg Asn Glu Ile Ile Lys Thr 
        755                 760                 765             


Ile Asp Asn Cys Leu Glu Gln Arg Ile Lys Arg Trp Lys Asp Ser Tyr 
    770                 775                 780                 


Glu Trp Met Met Gly Thr Trp Leu Ser Arg Ile Ile Thr Gln Phe Asn 
785                 790                 795                 800 


Asn Ile Ser Tyr Gln Met Tyr Asp Ser Leu Asn Tyr Gln Ala Gly Ala 
                805                 810                 815     


Ile Lys Ala Lys Ile Asp Leu Glu Tyr Lys Lys Tyr Ser Gly Ser Asp 
            820                 825                 830         


Lys Glu Asn Ile Lys Ser Gln Val Glu Asn Leu Lys Asn Ser Leu Asp 
        835                 840                 845             


Val Lys Ile Ser Glu Ala Met Asn Asn Ile Asn Lys Phe Ile Arg Glu 
    850                 855                 860                 


Cys Ser Val Thr Tyr Leu Phe Lys Asn Met Leu Pro Lys Val Ile Asp 
865                 870                 875                 880 


Glu Leu Asn Glu Phe Asp Arg Asn Thr Lys Ala Lys Leu Ile Asn Leu 
                885                 890                 895     


Ile Asp Ser His Asn Ile Ile Leu Val Gly Glu Val Asp Lys Leu Lys 
            900                 905                 910         


Ala Lys Val Asn Asn Ser Phe Gln Asn Thr Ile Pro Phe Asn Ile Phe 
        915                 920                 925             


Ser Tyr Thr Asn Asn Ser Leu Leu Lys Asp Ile Ile Asn Glu Tyr Phe 
    930                 935                 940                 


Asn Asn Ile Asn Asp Ser Lys Ile Leu Ser Leu Gln Asn Arg Lys Asn 
945                 950                 955                 960 


Thr Leu Val Asp Thr Ser Gly Tyr Asn Ala Glu Val Ser Glu Glu Gly 
                965                 970                 975     


Asp Val Gln Leu Asn Pro Ile Phe Pro Phe Asp Phe Lys Leu Gly Ser 
            980                 985                 990         


Ser Gly Glu Asp Arg Gly Lys Val  Ile Val Thr Gln Asn  Glu Asn Ile 
        995                 1000                 1005             


Val Tyr  Asn Ser Met Tyr Glu  Ser Phe Ser Ile Ser  Phe Trp Ile 
    1010                 1015                 1020             


Arg Ile  Asn Lys Trp Val Ser  Asn Leu Pro Gly Tyr  Thr Ile Ile 
    1025                 1030                 1035             


Asp Ser  Val Lys Asn Asn Ser  Gly Trp Ser Ile Gly  Ile Ile Ser 
    1040                 1045                 1050             


Asn Phe  Leu Val Phe Thr Leu  Lys Gln Asn Glu Asp  Ser Glu Gln 
    1055                 1060                 1065             


Ser Ile  Asn Phe Ser Tyr Asp  Ile Ser Asn Asn Ala  Pro Gly Tyr 
    1070                 1075                 1080             


Asn Lys  Trp Phe Phe Val Thr  Val Thr Asn Asn Met  Met Gly Asn 
    1085                 1090                 1095             


Met Lys  Ile Tyr Ile Asn Gly  Lys Leu Ile Asp Thr  Ile Lys Val 
    1100                 1105                 1110             


Lys Glu  Leu Thr Gly Ile Asn  Phe Ser Lys Thr Ile  Thr Phe Glu 
    1115                 1120                 1125             


Ile Asn  Lys Ile Pro Asp Thr  Gly Leu Ile Thr Ser  Asp Ser Asp 
    1130                 1135                 1140             


Asn Ile  Asn Met Trp Ile Arg  Asp Phe Tyr Ile Phe  Ala Lys Glu 
    1145                 1150                 1155             


Leu Asp  Gly Lys Asp Ile Asn  Ile Leu Phe Asn Ser  Leu Gln Tyr 
    1160                 1165                 1170             


Thr Asn  Val Val Lys Asp Tyr  Trp Gly Asn Asp Leu  Arg Tyr Asn 
    1175                 1180                 1185             


Lys Glu  Tyr Tyr Met Val Asn  Ile Asp Tyr Leu Asn  Arg Tyr Met 
    1190                 1195                 1200             


Tyr Ala  Asn Ser Arg Gln Ile  Val Phe Asn Thr Arg  Arg Asn Asn 
    1205                 1210                 1215             


Asn Asp  Phe Asn Glu Gly Tyr  Lys Ile Ile Ile Lys  Arg Ile Arg 
    1220                 1225                 1230             


Gly Asn  Thr Asn Asp Thr Arg  Val Arg Gly Gly Asp  Ile Leu Tyr 
    1235                 1240                 1245             


Phe Asp  Met Thr Ile Asn Asn  Lys Ala Tyr Asn Leu  Phe Met Lys 
    1250                 1255                 1260             


Asn Glu  Thr Met Tyr Ala Asp  Asn His Ser Thr Glu  Asp Ile Tyr 
    1265                 1270                 1275             


Ala Ile  Gly Leu Arg Glu Gln  Thr Lys Asp Ile Asn  Asp Asn Ile 
    1280                 1285                 1290             


Ile Phe  Gln Ile Gln Pro Met  Asn Asn Thr Tyr Tyr  Tyr Ala Ser 
    1295                 1300                 1305             


Gln Ile  Phe Lys Ser Asn Phe  Asn Gly Glu Asn Ile  Ser Gly Ile 
    1310                 1315                 1320             


Cys Ser  Ile Gly Thr Tyr Arg  Phe Arg Leu Gly Gly  Asp Trp Tyr 
    1325                 1330                 1335             


Arg His  Asn Tyr Leu Val Pro  Thr Val Lys Gln Gly  Asn Tyr Ala 
    1340                 1345                 1350             


Ser Leu  Leu Glu Ser Thr Ser  Thr His Trp Gly Phe  Val Pro Val 
    1355                 1360                 1365             


Ser Glu  Gly Ala Gly Tyr Pro  Tyr Asp Val Pro Asp  Tyr Ala Gly 
    1370                 1375                 1380             


Trp Glu  Leu Gln Gln Gly Ala  Gly Trp Ser His Pro  Gln Phe Glu 
    1385                 1390                 1395             


Lys Gly  Ala Gly Trp Ser His  Pro Gln Phe Glu Lys  Gly Ala Gly 
    1400                 1405                 1410             


Trp Ser  His Pro Gln Phe Glu  Lys 
    1415                 1420     


<210>  19
<211>  3746
<212>  DNA
<213>  Artificial

<220>
<223>  Propeptide fusion encoding sequence

<400>  19
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattgaagg aaggccgtca      360

aggccgcata gatctcggtc cgttcgaacc agaactctgg aagcttaact cctaaaaaac      420

cgccaccatg aaattcttag tcaacgttgc ccttgttttt atggtcgtat acatttctta      480

catctatgcg gccggacatc atcatcatca tcaccatcac caccaccacg acgtcggctg      540

ggagctgcaa cgtcgtcccc tgaactgcat cgtggctgtg tcccagaaca tgggtatcgg      600

caagaacggc gacctgccct ggcctcctct gcgtaacgag ttcaagtact tccagcgtat      660

gaccaccacc tcctccgtcg agggcaagca gaacctggtc atcatgggtc gcaagacctg      720

gttctccatc cccgagaaga accgtctgct gaaggaccgt atcaacatcg tgctgtcccg      780

cgagctgaag gaaccccctc gtggtgctca cttcctggct aagtccctgg acgacgctct      840

gcgtctgatc gagcagcctg agctggcttc caaggtggac atggtctgga tcgtgggcgg      900

ttcctccgtg taccaagagg ctatgaacca gcccggtcac ttgcgtctgt tcgtgacccg      960

tatcatgcaa gagttcgagt ccgacacctt cttccccgaa atcgacctgg gcaagtacaa     1020

gctgctgccc gagtaccccg gtgtcctgtc cgaggtgcaa gaggaaaagg gtatcaagta     1080

caagttcgag gtgtacgaga agaaggacgg cgcttccggt ttcgctaacg agctcggtcc     1140

tcgtctgatg ggaaagggcg ccggcggtgg tgctggtgct ggaccattcg tcaacaagca     1200

attcaactac aaggatcctg ttaacggtgt ggacatcgcc tacatcaaga ttccgaacgc     1260

aggccagatg caacctgtga aggctttcaa aatccacaac aaaatctggg tcattcccga     1320

gagagacaca ttcacgaacc cagaggaagg tgatctgaac cctcccccag aagccaagca     1380

ggtgccggtc tcttactacg attcaaccta cctcagtact gacaacgaga aggataacta     1440

cctgaagggc gttactaaac tcttcgagcg catctactcg acagacttgg gccgtatgct     1500

gctcacgtcc atcgtcaggg gtattccttt ctggggtggc tcaaccatcg acactgagct     1560

gaaggtcatt gatacaaact gcatcaacgt tattcaaccc gacggctcct accgcagcga     1620

ggaattgaac ctggtgatca ttggaccaag cgccgacatc attcagttcg agtgtaagtc     1680

tttcggccat gaagtcctca acttgaccag aaacggctac ggctccactc aatacatccg     1740

cttcagcccc gacttcacat tcggattcga ggaatcactg gaggtcgata cgaacccgtt     1800

gctgggtgct ggcaagttcg ccaccgaccc tgcagttctg ggcctcatgg gccttccttt     1860

cactgcccgc tttccagtcg ggaaacctgt cgtgccagct gcattaacat ggtcatagct     1920

gtttccttgc gtattgggcg ctctccgctt cctcgctcac tgactcgctg cgctcggtcg     1980

ttcgggtaaa gcctggggtg cctaatgagc aaaaggccag caaaaggcca ggaaccgtaa     2040

aaaggccgcg ttgctggcgt ttttccatag gctccgcccc cctgacgagc atcacaaaaa     2100

tcgacgctca agtcagaggt ggcgaaaccc gacaggacta taaagatacc aggcgtttcc     2160

ccctggaagc tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg gatacctgtc     2220

cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta ggtatctcag     2280

ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga     2340

ccgctgcgcc ttatccggta actatcgtct tgagtccaac ccggtaagac acgacttatc     2400

gccactggca gcagccactg gtaacaggat tagcagagcg aggtatgtag gcggtgctac     2460

agagttcttg aagtggtggc ctaactacgg ctacactaga agaacagtat ttggtatctg     2520

cgctctgctg aagccagtta ccttcggaaa aagagttggt agctcttgat ccggcaaaca     2580

aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa     2640

aggatctcaa gaagatcctt tgatcttttc tacggggtct gacgctcagt ggaacgaaaa     2700

ctcacgttaa gggattttgg tcatgagatt atcaaaaagg atcttcacct agatcctttt     2760

aaattaaaaa tgaagtttta aatcaatcta aagtatatat gagtaaactt ggtctgacag     2820

ttattagaaa aattcatcca gcagacgata aaacgcaata cgctggctat ccggtgccgc     2880

aatgccatac agcaccagaa aacgatccgc ccattcgccg cccagttctt ccgcaatatc     2940

acgggtggcc agcgcaatat cctgataacg atccgccacg cccagacggc cgcaatcaat     3000

aaagccgcta aaacggccat tttccaccat aatgttcggc aggcacgcat caccatgggt     3060

caccaccaga tcttcgccat ccggcatgct cgctttcaga cgcgcaaaca gctctgccgg     3120

tgccaggccc tgatgttctt catccagatc atcctgatcc accaggcccg cttccatacg     3180

ggtacgcgca cgttcaatac gatgtttcgc ctgatgatca aacggacagg tcgccgggtc     3240

cagggtatgc agacgacgca tggcatccgc cataatgctc actttttctg ccggcgccag     3300

atggctagac agcagatcct gacccggcac ttcgcccagc agcagccaat cacggcccgc     3360

ttcggtcacc acatccagca ccgccgcaca cggaacaccg gtggtggcca gccagctcag     3420

acgcgccgct tcatcctgca gctcgttcag cgcaccgctc agatcggttt tcacaaacag     3480

caccggacga ccctgcgcgc tcagacgaaa caccgccgca tcagagcagc caatggtctg     3540

ctgcgcccaa tcatagccaa acagacgttc cacccacgct gccgggctac ccgcatgcag     3600

gccatcctgt tcaatcatac tcttcctttt tcaatattat tgaagcattt atcagggtta     3660

ttgtctcatg agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc     3720

gcgcacattt ccccgaaaag tgccac                                          3746


<210>  20
<211>  469
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein

<400>  20

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ala Gly His His His His His His His His His 
            20                  25                  30          


His His Asp Val Gly Trp Glu Leu Gln Arg Arg Pro Leu Asn Cys Ile 
        35                  40                  45              


Val Ala Val Ser Gln Asn Met Gly Ile Gly Lys Asn Gly Asp Leu Pro 
    50                  55                  60                  


Trp Pro Pro Leu Arg Asn Glu Phe Lys Tyr Phe Gln Arg Met Thr Thr 
65                  70                  75                  80  


Thr Ser Ser Val Glu Gly Lys Gln Asn Leu Val Ile Met Gly Arg Lys 
                85                  90                  95      


Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg Leu Leu Lys Asp Arg Ile 
            100                 105                 110         


Asn Ile Val Leu Ser Arg Glu Leu Lys Glu Pro Pro Arg Gly Ala His 
        115                 120                 125             


Phe Leu Ala Lys Ser Leu Asp Asp Ala Leu Arg Leu Ile Glu Gln Pro 
    130                 135                 140                 


Glu Leu Ala Ser Lys Val Asp Met Val Trp Ile Val Gly Gly Ser Ser 
145                 150                 155                 160 


Val Tyr Gln Glu Ala Met Asn Gln Pro Gly His Leu Arg Leu Phe Val 
                165                 170                 175     


Thr Arg Ile Met Gln Glu Phe Glu Ser Asp Thr Phe Phe Pro Glu Ile 
            180                 185                 190         


Asp Leu Gly Lys Tyr Lys Leu Leu Pro Glu Tyr Pro Gly Val Leu Ser 
        195                 200                 205             


Glu Val Gln Glu Glu Lys Gly Ile Lys Tyr Lys Phe Glu Val Tyr Glu 
    210                 215                 220                 


Lys Lys Asp Gly Ala Ser Gly Phe Ala Asn Glu Leu Gly Pro Arg Leu 
225                 230                 235                 240 


Met Gly Lys Gly Ala Gly Gly Gly Ala Gly Ala Gly Pro Phe Val Asn 
                245                 250                 255     


Lys Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly Val Asp Ile Ala Tyr 
            260                 265                 270         


Ile Lys Ile Pro Asn Ala Gly Gln Met Gln Pro Val Lys Ala Phe Lys 
        275                 280                 285             


Ile His Asn Lys Ile Trp Val Ile Pro Glu Arg Asp Thr Phe Thr Asn 
    290                 295                 300                 


Pro Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu Ala Lys Gln Val Pro 
305                 310                 315                 320 


Val Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr Asp Asn Glu Lys Asp 
                325                 330                 335     


Asn Tyr Leu Lys Gly Val Thr Lys Leu Phe Glu Arg Ile Tyr Ser Thr 
            340                 345                 350         


Asp Leu Gly Arg Met Leu Leu Thr Ser Ile Val Arg Gly Ile Pro Phe 
        355                 360                 365             


Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys Val Ile Asp Thr Asn 
    370                 375                 380                 


Cys Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr Arg Ser Glu Glu Leu 
385                 390                 395                 400 


Asn Leu Val Ile Ile Gly Pro Ser Ala Asp Ile Ile Gln Phe Glu Cys 
                405                 410                 415     


Lys Ser Phe Gly His Glu Val Leu Asn Leu Thr Arg Asn Gly Tyr Gly 
            420                 425                 430         


Ser Thr Gln Tyr Ile Arg Phe Ser Pro Asp Phe Thr Phe Gly Phe Glu 
        435                 440                 445             


Glu Ser Leu Glu Val Asp Thr Asn Pro Leu Leu Gly Ala Gly Lys Phe 
    450                 455                 460                 


Ala Thr Asp Pro Ala 
465                 


<210>  21
<211>  3443
<212>  DNA
<213>  Artificial

<220>
<223>  Propeptide fusion encoding sequence

<400>  21
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattgaagg aaggccgtca      360

aggccgcata gatctcggtc cgttcgaacc agaactctgg aagcttaact cctaaaaaac      420

cgccaccatg aaattcttag tcaacgttgc ccttgttttt atggtcgtat acatttctta      480

catctatgcg gccggacacc accaccacca ccaccaccac caccaccacg acgtcggctg      540

ggagctgcaa cgtcgtcccc tgaactgcat cgtggctgtg tcccagaaca tgggtatcgg      600

caagaacggc gacctgccct ggcctcctct gcgtaacgag ttcaagtact tccagcgtat      660

gaccaccacc tcctccgtcg agggcaagca gaacctggtc atcatgggtc gcaagacctg      720

gttctccatc cccgagaaga accgtctgct gaaggaccgt atcaacatcg tgctgtcccg      780

cgagctgaag gaaccccctc gtggtgctca cttcctggct aagtccctgg acgacgctct      840

gcgtctgatc gagcagcctg agctggcttc caaggtggac atggtctgga tcgtgggcgg      900

ttcctccgtg taccaagagg ctatgaacca gcccggtcac ttgcgtctgt tcgtgacccg      960

tatcatgcaa gagttcgagt ccgacacctt cttccccgaa atcgacctgg gcaagtacaa     1020

gctgctgccc gagtaccccg gtgtcctgtc cgaggtgcaa gaggaaaagg gtatcaagta     1080

caagttcgag gtgtacgaga agaaggacgg cgcttccggt ttcgctaacg agctcggtcc     1140

tcgtctgatg ggaaagggcg ccggcggtgg tgctggtgct ggaccgatca ccatcaacaa     1200

cttcaattac tcggatccgg tggataacaa gaacatcctc tacttggaca cacacttgaa     1260

cacgctggct aacgagcctg aaaaagcttt caggatcacc ggcaacattt gggtcattcc     1320

ggataggttc agcagaaact ctaaccctaa cttgaacaaa cctcccagag tgacctcacc     1380

taagagtgga tactacgacc ccaactacct ctcgactgac tccgataaag accccttcct     1440

gaaggagatc attaaactct tcaagcgcat caactctcgt gaaattggcg aggaattgat     1500

ctaccgcctg agtacagaca tcccattccc gggtctgggc ctcatgggcc ttcctttcac     1560

tgcccgcttt ccagtcggga aacctgtcgt gccagctgca ttaacatggt catagctgtt     1620

tccttgcgta ttgggcgctc tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc     1680

gggtaaagcc tggggtgcct aatgagcaaa aggccagcaa aaggccagga accgtaaaaa     1740

ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg     1800

acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc     1860

tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc     1920

ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc     1980

ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg     2040

ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc     2100

actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga     2160

gttcttgaag tggtggccta actacggcta cactagaaga acagtatttg gtatctgcgc     2220

tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac     2280

caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg     2340

atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc     2400

acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa     2460

ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta     2520

ttagaaaaat tcatccagca gacgataaaa cgcaatacgc tggctatccg gtgccgcaat     2580

gccatacagc accagaaaac gatccgccca ttcgccgccc agttcttccg caatatcacg     2640

ggtggccagc gcaatatcct gataacgatc cgccacgccc agacggccgc aatcaataaa     2700

gccgctaaaa cggccatttt ccaccataat gttcggcagg cacgcatcac catgggtcac     2760

caccagatct tcgccatccg gcatgctcgc tttcagacgc gcaaacagct ctgccggtgc     2820

caggccctga tgttcttcat ccagatcatc ctgatccacc aggcccgctt ccatacgggt     2880

acgcgcacgt tcaatacgat gtttcgcctg atgatcaaac ggacaggtcg ccgggtccag     2940

ggtatgcaga cgacgcatgg catccgccat aatgctcact ttttctgccg gcgccagatg     3000

gctagacagc agatcctgac ccggcacttc gcccagcagc agccaatcac ggcccgcttc     3060

ggtcaccaca tccagcaccg ccgcacacgg aacaccggtg gtggccagcc agctcagacg     3120

cgccgcttca tcctgcagct cgttcagcgc accgctcaga tcggttttca caaacagcac     3180

cggacgaccc tgcgcgctca gacgaaacac cgccgcatca gagcagccaa tggtctgctg     3240

cgcccaatca tagccaaaca gacgttccac ccacgctgcc gggctacccg catgcaggcc     3300

atcctgttca atcatactct tcctttttca atattattga agcatttatc agggttattg     3360

tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg     3420

cacatttccc cgaaaagtgc cac                                             3443


<210>  22
<211>  369
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein

<400>  22

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ala Gly His His His His His His His His His 
            20                  25                  30          


His His Asp Val Gly Trp Glu Leu Gln Arg Arg Pro Leu Asn Cys Ile 
        35                  40                  45              


Val Ala Val Ser Gln Asn Met Gly Ile Gly Lys Asn Gly Asp Leu Pro 
    50                  55                  60                  


Trp Pro Pro Leu Arg Asn Glu Phe Lys Tyr Phe Gln Arg Met Thr Thr 
65                  70                  75                  80  


Thr Ser Ser Val Glu Gly Lys Gln Asn Leu Val Ile Met Gly Arg Lys 
                85                  90                  95      


Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg Leu Leu Lys Asp Arg Ile 
            100                 105                 110         


Asn Ile Val Leu Ser Arg Glu Leu Lys Glu Pro Pro Arg Gly Ala His 
        115                 120                 125             


Phe Leu Ala Lys Ser Leu Asp Asp Ala Leu Arg Leu Ile Glu Gln Pro 
    130                 135                 140                 


Glu Leu Ala Ser Lys Val Asp Met Val Trp Ile Val Gly Gly Ser Ser 
145                 150                 155                 160 


Val Tyr Gln Glu Ala Met Asn Gln Pro Gly His Leu Arg Leu Phe Val 
                165                 170                 175     


Thr Arg Ile Met Gln Glu Phe Glu Ser Asp Thr Phe Phe Pro Glu Ile 
            180                 185                 190         


Asp Leu Gly Lys Tyr Lys Leu Leu Pro Glu Tyr Pro Gly Val Leu Ser 
        195                 200                 205             


Glu Val Gln Glu Glu Lys Gly Ile Lys Tyr Lys Phe Glu Val Tyr Glu 
    210                 215                 220                 


Lys Lys Asp Gly Ala Ser Gly Phe Ala Asn Glu Leu Gly Pro Arg Leu 
225                 230                 235                 240 


Met Gly Lys Gly Ala Gly Gly Gly Ala Gly Ala Gly Pro Ile Thr Ile 
                245                 250                 255     


Asn Asn Phe Asn Tyr Ser Asp Pro Val Asp Asn Lys Asn Ile Leu Tyr 
            260                 265                 270         


Leu Asp Thr His Leu Asn Thr Leu Ala Asn Glu Pro Glu Lys Ala Phe 
        275                 280                 285             


Arg Ile Thr Gly Asn Ile Trp Val Ile Pro Asp Arg Phe Ser Arg Asn 
    290                 295                 300                 


Ser Asn Pro Asn Leu Asn Lys Pro Pro Arg Val Thr Ser Pro Lys Ser 
305                 310                 315                 320 


Gly Tyr Tyr Asp Pro Asn Tyr Leu Ser Thr Asp Ser Asp Lys Asp Pro 
                325                 330                 335     


Phe Leu Lys Glu Ile Ile Lys Leu Phe Lys Arg Ile Asn Ser Arg Glu 
            340                 345                 350         


Ile Gly Glu Glu Leu Ile Tyr Arg Leu Ser Thr Asp Ile Pro Phe Pro 
        355                 360                 365             


Gly 
    


<210>  23
<211>  9586
<212>  DNA
<213>  Artificial

<220>
<223>  Propeptide fusion encoding sequence

<400>  23
gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc       60

gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc      120

acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt      180

agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg      240

ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt      300

ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta      360

taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt      420

aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt tcggggaaat      480

gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg      540

agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa      600

catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac      660

ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac      720

atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt      780

ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc      840

gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca      900

ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc      960

ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag     1020

gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa     1080

ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg     1140

gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa     1200

ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg     1260

gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt     1320

gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt     1380

caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag     1440

cattggtaac tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat     1500

ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct     1560

taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct     1620

tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca     1680

gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc     1740

agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc     1800

aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct     1860

gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag     1920

gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc     1980

tacaccgaac tgagatacct acagcgtgag cattgagaaa gcgccacgct tcccgaaggg     2040

agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag     2100

cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt     2160

gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac     2220

gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg     2280

ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc     2340

cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcctgatg     2400

cggtattttc tccttacgca tctgtgcggt atttcacacc gcagaccagc cgcgtaacct     2460

ggcaaaatcg gttacggttg agtaataaat ggatgccctg cgtaagcggg tgtgggcgga     2520

caataaagtc ttaaactgaa caaaatagat ctaaactatg acaataaagt cttaaactag     2580

acagaatagt tgtaaactga aatcagtcca gttatgctgt gaaaaagcat actggacttt     2640

tgttatggct aaagcaaact cttcattttc tgaagtgcaa attgcccgtc gtattaaaga     2700

ggggcgtggc caagggcatg gtaaagacta tattcgcggc gttgtgacaa tttaccgaac     2760

aactccgcgg ccgggaagcc gatctcggct tgaacgaatt gttaggtggc ggtacttggg     2820

tcgatatcaa agtgcatcac ttcttcccgt atgcccaact ttgtatagag agccactgcg     2880

ggatcgtcac cgtaatctgc ttgcacgtag atcacataag caccaagcgc gttggcctca     2940

tgcttgagga gattgatgag cgcggtggca atgccctgcc tccggtgctc gccggagact     3000

gcgagatcat agatatagat ctcactacgc ggctgctcaa acctgggcag aacgtaagcc     3060

gcgagagcgc caacaaccgc ttcttggtcg aaggcagcaa gcgcgatgaa tgtcttacta     3120

cggagcaagt tcccgaggta atcggagtcc ggctgatgtt gggagtaggt ggctacgtct     3180

ccgaactcac gaccgaaaag atcaagagca gcccgcatgg atttgacttg gtcagggccg     3240

agcctacatg tgcgaatgat gcccatactt gagccaccta actttgtttt agggcgactg     3300

ccctgctgcg taacatcgtt gctgctgcgt aacatcgttg ctgctccata acatcaaaca     3360

tcgacccacg gcgtaacgcg cttgctgctt ggatgcccga ggcatagact gtacaaaaaa     3420

acagtcataa caagccatga aaaccgccac tgcgccgtta ccaccgctgc gttcggtcaa     3480

ggttctggac cagttgcgtg agcgcatacg ctacttgcat tacagtttac gaaccgaaca     3540

ggcttatgtc aactgggttc gtgccttcat ccgtttccac ggtgtgcgtc acccggcaac     3600

cttgggcagc agcgaagtcg aggcatttct gtcctggctg gcgaacgagc gcaaggtttc     3660

ggtctccacg catcgtcagg cattggcggc cttgctgttc ttctacggca aggtgctgtg     3720

cacggatctg ccctggcttc aggagatcgg aagacctcgg ccgtcgcggc gcttgccggt     3780

ggtgctgacc ccggatgaag tggttcgcat cctcggtttt ctggaaggcg agcatcgttt     3840

gttcgcccag gactctagct atagttctag tggttggcta cgtatactcc ggaatattaa     3900

tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt     3960

ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca     4020

ccatcgggcg cggatctcgg tccgttcgaa ccagaactct ggaagcttaa ctcctaaaaa     4080

accgccacca tgaaattctt agtcaacgtt gcccttgttt ttatggtcgt atacatttct     4140

tacatctatg cggccggaca tcatcatcat catcaccatc accaccacca cgacgtcggc     4200

tgggagctgc aacgtcgtcc cctgaactgc atcgtggctg tgtcccagaa catgggtatc     4260

ggcaagaacg gcgacctgcc ctggcctcct ctgcgtaacg agttcaagta cttccagcgt     4320

atgaccacca cctcctccgt cgagggcaag cagaacctgg tcatcatggg tcgcaagacc     4380

tggttctcca tccccgagaa gaaccgtctg ctgaaggacc gtatcaacat cgtgctgtcc     4440

cgcgagctga aggaaccccc tcgtggtgct cacttcctgg ctaagtccct ggacgacgct     4500

ctgcgtctga tcgagcagcc tgagctggct tccaaggtgg acatggtctg gatcgtgggc     4560

ggttcctccg tgtaccaaga ggctatgaac cagcccggtc acttgcgtct gttcgtgacc     4620

cgtatcatgc aagagttcga gtccgacacc ttcttccccg aaatcgacct gggcaagtac     4680

aagctgctgc ccgagtaccc cggtgtcctg tccgaggtgc aagaggaaaa gggtatcaag     4740

tacaagttcg aggtgtacga gaagaaggac ggcgcttccg gtttcgctaa cgagctcggt     4800

cctcgtctga tgggaaaggg cgccggcggt ggtgctggtg ctggaccatt cgtcaacaag     4860

caattcaact acaaggatcc tgttaacggt gtggacatcg cctacatcaa gattccgaac     4920

gcaggccaga tgcaacctgt gaaggctttc aaaatccaca acaaaatctg ggtcattccc     4980

gagagagaca cattcacgaa cccagaggaa ggtgatctga accctccccc agaagccaag     5040

caggtgccgg tctcttacta cgattcaacc tacctcagta ctgacaacga gaaggataac     5100

tacctgaagg gcgttactaa actcttcgag cgcatctact cgacagactt gggccgtatg     5160

ctgctcacgt ccatcgtcag gggtattcct ttctggggtg gctcaaccat cgacactgag     5220

ctgaaggtca ttgatacaaa ctgcatcaac gttattcaac ccgacggctc ctaccgcagc     5280

gaggaattga acctggtgat cattggacca agcgccgaca tcattcagtt cgagtgtaag     5340

tctttcggcc atgaagtcct caacttgacc agaaacggct acggctccac tcaatacatc     5400

cgcttcagcc ccgacttcac attcggattc gaggaatcac tggaggtcga tacgaacccg     5460

ttgctgggtg ctggcaagtt cgccaccgac cctgcagtta ctctggcaca cgcgctcatc     5520

cacgcgggac atcgtctgta cggtatcgct attaacccaa acagggtctt caaggttaac     5580

accaacgcct actacgagat gagtggtctg gaagtgtcgt tcgaggaact ccgtacgttc     5640

ggaggtcacg acgcaaagtt catcgatagt ttgcaggaga acgaattccg cctgtactac     5700

tacaacaagt tcaaagacat cgcgtctaca ctcaacaagg ctaaaagcat tgttggaacc     5760

actgctagtt tgcaatacat gaagaacgtg ttcaaggaga aatacctctt gtcggaagac     5820

acctccggta aattcagcgt ggacaagctg aaattcgata agttgtacaa aatgctgaca     5880

gaaatctaca cggaagacaa cttcgttaag ttcttcaaag tgttgaaccg taagaccgct     5940

ctgaacttcg ataaggctgt cttcaaaatc aacattgtgc ctaaagtcaa ctacaccatc     6000

tacgacggtt tcaacctccg caacactaac ttggctgcca acttcaacgg ccagaacact     6060

gagatcaaca acatgaactt cacaaagctc aaaaacttca ccggtttgtt cgagttctac     6120

aagctgctct gcgtgcgtgg tggaggcaca tctcacacgc aatctggctg ggaactccag     6180

caaggtggcc agggtggagc tctgaacgat ctgtgtatca aggtgaataa ctgggatctg     6240

ttctttagcc caagcgagga taacttcacg aacgatctca acaaaggtga agagatcacg     6300

tctgatacca atatcgaagc ggctgaagag aatatctcct tggatctcat ccagcaatat     6360

tacctgacct ttaacttcga taacgagccc gaaaacatct ccatcgagaa cctcagctca     6420

gacatcattg gtcagttgga gctgatgcca aacattgaac gcttccccaa cggcaagaaa     6480

tacgaactcg acaagtatac gatgtttcat tacttaagag cgcaggagtt tgaacacggc     6540

aagagccgca ttgctctcac taactccgtg aatgaagccc tgctcaatcc gtcaagggtg     6600

tacacattct ttagctccga ctatgtcaag aaagtgaaca aagccaccga agcggcaatg     6660

ttcctgggat gggttgaaca actggtctac gacttcaccg acgagacctc tgaggtgagc     6720

acaacggaca agattgctga catcactatc attatcccgt atattggacc tgccttgaat     6780

attggcaaca tgctctacaa agacgatttc gttggtgccc tgatcttcag cggtgccgtg     6840

atcctgttgg agttcattcc tgaaatcgcc atccctgtgc tgggcacgtt cgctctggtc     6900

tcatacattg cgaataargt cttgaccgtg cagacaatcg ataatgccct ctccaaacgt     6960

aacgaaaaat gggacgaggt ctacaaatac atcgtgacca actggctggc aaaggttaac     7020

acccaaattg atctgatccg taagaaaatg aaggaggctt tggagaacca ggctgaagct     7080

actaaagcca ttatcaacta ccagtataat cagtatacag aagaggaaaa gaataacatc     7140

aatttcaaca tcgatgactt gtcctcaaag ctgaacgagt ccatcaacaa agctatgatc     7200

aacatcaaca aattcctgaa tcagtgctcc gtgtcttacc tgatgaactc tatgatccca     7260

tacggtgtga agcgcctgga ggacttcgat gccagcctga aagacgcact gctcaaatac     7320

atttacgata atcgcggcac tttgattggc caagttgacc gtctgaagga caaggttaac     7380

aataccttgt caaccgatat ccccttccaa ctctctaagt acgtcgataa ccagcgcttg     7440

ctgagcacct tcacagaata catcaacaac atcatcaaca cctccatcct gaacctccgt     7500

tacgagtcta accacctcat cgacttgagc agatacgcta gcaagatcaa catcggttcc     7560

aaggtgaact tcgacccaat cgataagaac cagatccaac tgttcaacct cgaatcctct     7620

aagatcgaag tgatcctgaa gaacgctatc gtctacaact ccatgtacga aaacttctct     7680

accagcttct ggatcaggat tccgaaatac ttcaactcaa tctcgctcaa caacgagtac     7740

actatcatca actgcatgga aaacaactcg ggatggaagg tgtccctcaa ctacggcgag     7800

atcatctgga ctttgcagga cacacaagaa atcaagcaga gggtcgtgtt caagtacagc     7860

caaatgatca acatcagcga ttacatcaac cgttggatct tcgtcacaat caccaacaac     7920

cgcctgaaca actccaagat ttacatcaac ggtagactga tcgaccagaa gccaatcagc     7980

aacctcggca acatccacgc ctcaaacaac atcatgttca agttggacgg ctgtagggat     8040

acacacagat acatctggat caaatacttc aacctgttcg acaaggagct caacgagaag     8100

gaaatcaagg acctctacga taaccagtcc aactctggta tcttgaagga cttctggggc     8160

gattacctgc aatacgacaa gccctactac atgttgaacc tgtacgaccc taacaagtac     8220

gttgatgtga acaacgtcgg tatcaggggc tacatgtacc tgaagggacc acgtggttct     8280

gttatgacca ctaacatcta cctcaacagc tcattgtacc gtggcacaaa gttcatcatc     8340

aagaagtacg cctccggaaa caaggacaac atcgtccgta acaacgatcg cgtttacatc     8400

aacgttgtgg tcaagaacaa ggagtacaga ctggctacca acgcttcgca ggctggagtt     8460

gagaagatcc tgtctgctct ggaaatccct gacgtgggca acctctcaca ggttgtggtc     8520

atgaagtcga agaacgatca aggcatcact aacaagtgca agatgaactt gcaggacaac     8580

aacggaaacg acatcggctt catcggattc caccaattca acaacatcgc caagttggtg     8640

gccagcaact ggtacaaccg tcagatcgag cgttcgtccc gcaccttagg atgctcgtgg     8700

gagttcattc cagtcgatga cggatgggga gagagacctt tgggcgcagg aggatgggaa     8760

ctccagcaag gttaccccta cgatgtccct gactacgctg gtgcaggatg gtcccaccca     8820

caattcgaga agggtgcagg atggagtcac ccacagttcg agaagggcgc tggatggtcc     8880

cacccacagt tcgagaaata attagttgat gcatagttaa ttagatagct cgaggcatgc     8940

ggtaccaagc ttgtcgagaa gtactagagg atcataatca gccataccac atttgtagag     9000

gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca taaaatgaat     9060

gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata aagcaatagc     9120

atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa     9180

ctcatcaatg tatcttatca tgtctggatc tgatcactgc ttgagcctag gagatccgaa     9240

ccagataagt gaaatctagt tccaaactat tttgtcattt ttaattttcg tattagctta     9300

cgacgctaca cccagttccc atctattttg tcactcttcc ctaaataatc cttaaaaact     9360

ccatttccac ccctcccagt tcccaactat tttgtccgcc cacagcgggg catttttctt     9420

cctgttatgt ttttaatcaa acatcctgcc aactccatgt gacaaaccgt catcttcggc     9480

tactttttct ctgtcacaga atgaaaattt ttctgtcatc tcttcgttat taatgtttgt     9540

aattgactga atatcaacgc ttatttgcag cctgaatggc gaatgg                    9586


<210>  24
<211>  1603
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein

<400>  24

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ala Gly His His His His His His His His His 
            20                  25                  30          


His His Asp Val Gly Trp Glu Leu Gln Arg Arg Pro Leu Asn Cys Ile 
        35                  40                  45              


Val Ala Val Ser Gln Asn Met Gly Ile Gly Lys Asn Gly Asp Leu Pro 
    50                  55                  60                  


Trp Pro Pro Leu Arg Asn Glu Phe Lys Tyr Phe Gln Arg Met Thr Thr 
65                  70                  75                  80  


Thr Ser Ser Val Glu Gly Lys Gln Asn Leu Val Ile Met Gly Arg Lys 
                85                  90                  95      


Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg Leu Leu Lys Asp Arg Ile 
            100                 105                 110         


Asn Ile Val Leu Ser Arg Glu Leu Lys Glu Pro Pro Arg Gly Ala His 
        115                 120                 125             


Phe Leu Ala Lys Ser Leu Asp Asp Ala Leu Arg Leu Ile Glu Gln Pro 
    130                 135                 140                 


Glu Leu Ala Ser Lys Val Asp Met Val Trp Ile Val Gly Gly Ser Ser 
145                 150                 155                 160 


Val Tyr Gln Glu Ala Met Asn Gln Pro Gly His Leu Arg Leu Phe Val 
                165                 170                 175     


Thr Arg Ile Met Gln Glu Phe Glu Ser Asp Thr Phe Phe Pro Glu Ile 
            180                 185                 190         


Asp Leu Gly Lys Tyr Lys Leu Leu Pro Glu Tyr Pro Gly Val Leu Ser 
        195                 200                 205             


Glu Val Gln Glu Glu Lys Gly Ile Lys Tyr Lys Phe Glu Val Tyr Glu 
    210                 215                 220                 


Lys Lys Asp Gly Ala Ser Gly Phe Ala Asn Glu Leu Gly Pro Arg Leu 
225                 230                 235                 240 


Met Gly Lys Gly Ala Gly Gly Gly Ala Gly Ala Gly Pro Phe Val Asn 
                245                 250                 255     


Lys Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly Val Asp Ile Ala Tyr 
            260                 265                 270         


Ile Lys Ile Pro Asn Ala Gly Gln Met Gln Pro Val Lys Ala Phe Lys 
        275                 280                 285             


Ile His Asn Lys Ile Trp Val Ile Pro Glu Arg Asp Thr Phe Thr Asn 
    290                 295                 300                 


Pro Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu Ala Lys Gln Val Pro 
305                 310                 315                 320 


Val Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr Asp Asn Glu Lys Asp 
                325                 330                 335     


Asn Tyr Leu Lys Gly Val Thr Lys Leu Phe Glu Arg Ile Tyr Ser Thr 
            340                 345                 350         


Asp Leu Gly Arg Met Leu Leu Thr Ser Ile Val Arg Gly Ile Pro Phe 
        355                 360                 365             


Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys Val Ile Asp Thr Asn 
    370                 375                 380                 


Cys Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr Arg Ser Glu Glu Leu 
385                 390                 395                 400 


Asn Leu Val Ile Ile Gly Pro Ser Ala Asp Ile Ile Gln Phe Glu Cys 
                405                 410                 415     


Lys Ser Phe Gly His Glu Val Leu Asn Leu Thr Arg Asn Gly Tyr Gly 
            420                 425                 430         


Ser Thr Gln Tyr Ile Arg Phe Ser Pro Asp Phe Thr Phe Gly Phe Glu 
        435                 440                 445             


Glu Ser Leu Glu Val Asp Thr Asn Pro Leu Leu Gly Ala Gly Lys Phe 
    450                 455                 460                 


Ala Thr Asp Pro Ala Val Thr Leu Ala His Ala Leu Ile His Ala Gly 
465                 470                 475                 480 


His Arg Leu Tyr Gly Ile Ala Ile Asn Pro Asn Arg Val Phe Lys Val 
                485                 490                 495     


Asn Thr Asn Ala Tyr Tyr Glu Met Ser Gly Leu Glu Val Ser Phe Glu 
            500                 505                 510         


Glu Leu Arg Thr Phe Gly Gly His Asp Ala Lys Phe Ile Asp Ser Leu 
        515                 520                 525             


Gln Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn Lys Phe Lys Asp Ile 
    530                 535                 540                 


Ala Ser Thr Leu Asn Lys Ala Lys Ser Ile Val Gly Thr Thr Ala Ser 
545                 550                 555                 560 


Leu Gln Tyr Met Lys Asn Val Phe Lys Glu Lys Tyr Leu Leu Ser Glu 
                565                 570                 575     


Asp Thr Ser Gly Lys Phe Ser Val Asp Lys Leu Lys Phe Asp Lys Leu 
            580                 585                 590         


Tyr Lys Met Leu Thr Glu Ile Tyr Thr Glu Asp Asn Phe Val Lys Phe 
        595                 600                 605             


Phe Lys Val Leu Asn Arg Lys Thr Ala Leu Asn Phe Asp Lys Ala Val 
    610                 615                 620                 


Phe Lys Ile Asn Ile Val Pro Lys Val Asn Tyr Thr Ile Tyr Asp Gly 
625                 630                 635                 640 


Phe Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn Phe Asn Gly Gln Asn 
                645                 650                 655     


Thr Glu Ile Asn Asn Met Asn Phe Thr Lys Leu Lys Asn Phe Thr Gly 
            660                 665                 670         


Leu Phe Glu Phe Tyr Lys Leu Leu Cys Val Arg Gly Gly Gly Thr Ser 
        675                 680                 685             


His Thr Gln Ser Gly Trp Glu Leu Gln Gln Gly Gly Gln Gly Gly Ala 
    690                 695                 700                 


Leu Asn Asp Leu Cys Ile Lys Val Asn Asn Trp Asp Leu Phe Phe Ser 
705                 710                 715                 720 


Pro Ser Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu Ile 
                725                 730                 735     


Thr Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp 
            740                 745                 750         


Leu Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu 
        755                 760                 765             


Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu Glu 
    770                 775                 780                 


Leu Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu Leu 
785                 790                 795                 800 


Asp Lys Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu His 
                805                 810                 815     


Gly Lys Ser Arg Ile Ala Leu Thr Asn Ser Val Asn Glu Ala Leu Leu 
            820                 825                 830         


Asn Pro Ser Arg Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys Lys 
        835                 840                 845             


Val Asn Lys Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu Gln 
    850                 855                 860                 


Leu Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp 
865                 870                 875                 880 


Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu 
                885                 890                 895     


Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu Ile 
            900                 905                 910         


Phe Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala Ile 
        915                 920                 925             


Pro Val Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys Val 
    930                 935                 940                 


Leu Thr Val Gln Thr Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu Lys 
945                 950                 955                 960 


Trp Asp Glu Val Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys Val 
                965                 970                 975     


Asn Thr Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu Glu 
            980                 985                 990         


Asn Gln Ala Glu Ala Thr Lys Ala  Ile Ile Asn Tyr Gln  Tyr Asn Gln 
        995                 1000                 1005             


Tyr Thr  Glu Glu Glu Lys Asn  Asn Ile Asn Phe Asn  Ile Asp Asp 
    1010                 1015                 1020             


Leu Ser  Ser Lys Leu Asn Glu  Ser Ile Asn Lys Ala  Met Ile Asn 
    1025                 1030                 1035             


Ile Asn  Lys Phe Leu Asn Gln  Cys Ser Val Ser Tyr  Leu Met Asn 
    1040                 1045                 1050             


Ser Met  Ile Pro Tyr Gly Val  Lys Arg Leu Glu Asp  Phe Asp Ala 
    1055                 1060                 1065             


Ser Leu  Lys Asp Ala Leu Leu  Lys Tyr Ile Tyr Asp  Asn Arg Gly 
    1070                 1075                 1080             


Thr Leu  Ile Gly Gln Val Asp  Arg Leu Lys Asp Lys  Val Asn Asn 
    1085                 1090                 1095             


Thr Leu  Ser Thr Asp Ile Pro  Phe Gln Leu Ser Lys  Tyr Val Asp 
    1100                 1105                 1110             


Asn Gln  Arg Leu Leu Ser Thr  Phe Thr Glu Tyr Ile  Asn Asn Ile 
    1115                 1120                 1125             


Ile Asn  Thr Ser Ile Leu Asn  Leu Arg Tyr Glu Ser  Asn His Leu 
    1130                 1135                 1140             


Ile Asp  Leu Ser Arg Tyr Ala  Ser Lys Ile Asn Ile  Gly Ser Lys 
    1145                 1150                 1155             


Val Asn  Phe Asp Pro Ile Asp  Lys Asn Gln Ile Gln  Leu Phe Asn 
    1160                 1165                 1170             


Leu Glu  Ser Ser Lys Ile Glu  Val Ile Leu Lys Asn  Ala Ile Val 
    1175                 1180                 1185             


Tyr Asn  Ser Met Tyr Glu Asn  Phe Ser Thr Ser Phe  Trp Ile Arg 
    1190                 1195                 1200             


Ile Pro  Lys Tyr Phe Asn Ser  Ile Ser Leu Asn Asn  Glu Tyr Thr 
    1205                 1210                 1215             


Ile Ile  Asn Cys Met Glu Asn  Asn Ser Gly Trp Lys  Val Ser Leu 
    1220                 1225                 1230             


Asn Tyr  Gly Glu Ile Ile Trp  Thr Leu Gln Asp Thr  Gln Glu Ile 
    1235                 1240                 1245             


Lys Gln  Arg Val Val Phe Lys  Tyr Ser Gln Met Ile  Asn Ile Ser 
    1250                 1255                 1260             


Asp Tyr  Ile Asn Arg Trp Ile  Phe Val Thr Ile Thr  Asn Asn Arg 
    1265                 1270                 1275             


Leu Asn  Asn Ser Lys Ile Tyr  Ile Asn Gly Arg Leu  Ile Asp Gln 
    1280                 1285                 1290             


Lys Pro  Ile Ser Asn Leu Gly  Asn Ile His Ala Ser  Asn Asn Ile 
    1295                 1300                 1305             


Met Phe  Lys Leu Asp Gly Cys  Arg Asp Thr His Arg  Tyr Ile Trp 
    1310                 1315                 1320             


Ile Lys  Tyr Phe Asn Leu Phe  Asp Lys Glu Leu Asn  Glu Lys Glu 
    1325                 1330                 1335             


Ile Lys  Asp Leu Tyr Asp Asn  Gln Ser Asn Ser Gly  Ile Leu Lys 
    1340                 1345                 1350             


Asp Phe  Trp Gly Asp Tyr Leu  Gln Tyr Asp Lys Pro  Tyr Tyr Met 
    1355                 1360                 1365             


Leu Asn  Leu Tyr Asp Pro Asn  Lys Tyr Val Asp Val  Asn Asn Val 
    1370                 1375                 1380             


Gly Ile  Arg Gly Tyr Met Tyr  Leu Lys Gly Pro Arg  Gly Ser Val 
    1385                 1390                 1395             


Met Thr  Thr Asn Ile Tyr Leu  Asn Ser Ser Leu Tyr  Arg Gly Thr 
    1400                 1405                 1410             


Lys Phe  Ile Ile Lys Lys Tyr  Ala Ser Gly Asn Lys  Asp Asn Ile 
    1415                 1420                 1425             


Val Arg  Asn Asn Asp Arg Val  Tyr Ile Asn Val Val  Val Lys Asn 
    1430                 1435                 1440             


Lys Glu  Tyr Arg Leu Ala Thr  Asn Ala Ser Gln Ala  Gly Val Glu 
    1445                 1450                 1455             


Lys Ile  Leu Ser Ala Leu Glu  Ile Pro Asp Val Gly  Asn Leu Ser 
    1460                 1465                 1470             


Gln Val  Val Val Met Lys Ser  Lys Asn Asp Gln Gly  Ile Thr Asn 
    1475                 1480                 1485             


Lys Cys  Lys Met Asn Leu Gln  Asp Asn Asn Gly Asn  Asp Ile Gly 
    1490                 1495                 1500             


Phe Ile  Gly Phe His Gln Phe  Asn Asn Ile Ala Lys  Leu Val Ala 
    1505                 1510                 1515             


Ser Asn  Trp Tyr Asn Arg Gln  Ile Glu Arg Ser Ser  Arg Thr Leu 
    1520                 1525                 1530             


Gly Cys  Ser Trp Glu Phe Ile  Pro Val Asp Asp Gly  Trp Gly Glu 
    1535                 1540                 1545             


Arg Pro  Leu Gly Ala Gly Gly  Trp Glu Leu Gln Gln  Gly Tyr Pro 
    1550                 1555                 1560             


Tyr Asp  Val Pro Asp Tyr Ala  Gly Ala Gly Trp Ser  His Pro Gln 
    1565                 1570                 1575             


Phe Glu  Lys Gly Ala Gly Trp  Ser His Pro Gln Phe  Glu Lys Gly 
    1580                 1585                 1590             


Ala Gly  Trp Ser His Pro Gln  Phe Glu Lys 
    1595                 1600             


<210>  25
<211>  9650
<212>  DNA
<213>  Artificial

<220>
<223>  Propeptide fusion encoding sequence

<400>  25
gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc       60

gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc      120

acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt      180

agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg      240

ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt      300

ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta      360

taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt      420

aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt tcggggaaat      480

gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg      540

agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa      600

catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac      660

ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac      720

atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt      780

ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc      840

gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca      900

ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc      960

ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag     1020

gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa     1080

ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg     1140

gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa     1200

ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg     1260

gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt     1320

gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt     1380

caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag     1440

cattggtaac tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat     1500

ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct     1560

taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct     1620

tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca     1680

gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc     1740

agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc     1800

aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct     1860

gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag     1920

gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc     1980

tacaccgaac tgagatacct acagcgtgag cattgagaaa gcgccacgct tcccgaaggg     2040

agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag     2100

cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt     2160

gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac     2220

gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg     2280

ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc     2340

cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcctgatg     2400

cggtattttc tccttacgca tctgtgcggt atttcacacc gcagaccagc cgcgtaacct     2460

ggcaaaatcg gttacggttg agtaataaat ggatgccctg cgtaagcggg tgtgggcgga     2520

caataaagtc ttaaactgaa caaaatagat ctaaactatg acaataaagt cttaaactag     2580

acagaatagt tgtaaactga aatcagtcca gttatgctgt gaaaaagcat actggacttt     2640

tgttatggct aaagcaaact cttcattttc tgaagtgcaa attgcccgtc gtattaaaga     2700

ggggcgtggc caagggcatg gtaaagacta tattcgcggc gttgtgacaa tttaccgaac     2760

aactccgcgg ccgggaagcc gatctcggct tgaacgaatt gttaggtggc ggtacttggg     2820

tcgatatcaa agtgcatcac ttcttcccgt atgcccaact ttgtatagag agccactgcg     2880

ggatcgtcac cgtaatctgc ttgcacgtag atcacataag caccaagcgc gttggcctca     2940

tgcttgagga gattgatgag cgcggtggca atgccctgcc tccggtgctc gccggagact     3000

gcgagatcat agatatagat ctcactacgc ggctgctcaa acctgggcag aacgtaagcc     3060

gcgagagcgc caacaaccgc ttcttggtcg aaggcagcaa gcgcgatgaa tgtcttacta     3120

cggagcaagt tcccgaggta atcggagtcc ggctgatgtt gggagtaggt ggctacgtct     3180

ccgaactcac gaccgaaaag atcaagagca gcccgcatgg atttgacttg gtcagggccg     3240

agcctacatg tgcgaatgat gcccatactt gagccaccta actttgtttt agggcgactg     3300

ccctgctgcg taacatcgtt gctgctgcgt aacatcgttg ctgctccata acatcaaaca     3360

tcgacccacg gcgtaacgcg cttgctgctt ggatgcccga ggcatagact gtacaaaaaa     3420

acagtcataa caagccatga aaaccgccac tgcgccgtta ccaccgctgc gttcggtcaa     3480

ggttctggac cagttgcgtg agcgcatacg ctacttgcat tacagtttac gaaccgaaca     3540

ggcttatgtc aactgggttc gtgccttcat ccgtttccac ggtgtgcgtc acccggcaac     3600

cttgggcagc agcgaagtcg aggcatttct gtcctggctg gcgaacgagc gcaaggtttc     3660

ggtctccacg catcgtcagg cattggcggc cttgctgttc ttctacggca aggtgctgtg     3720

cacggatctg ccctggcttc aggagatcgg aagacctcgg ccgtcgcggc gcttgccggt     3780

ggtgctgacc ccggatgaag tggttcgcat cctcggtttt ctggaaggcg agcatcgttt     3840

gttcgcccag gactctagct atagttctag tggttggcta cgtatactcc ggaatattaa     3900

tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt     3960

ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca     4020

ccatcgggcg cggatctcgg tccgttcgaa ccagaactct ggaagcttaa ctcctaaaaa     4080

accgccacca tgaaattctt agtcaacgtt gcccttgttt ttatggtcgt atacatttct     4140

tacatctatg cggccggaca ccaccaccac caccaccacc accaccacca cgacgtcggc     4200

tgggagctgc aacgtcgtcc cctgaactgc atcgtggctg tgtcccagaa catgggtatc     4260

ggcaagaacg gcgacctgcc ctggcctcct ctgcgtaacg agttcaagta cttccagcgt     4320

atgaccacca cctcctccgt cgagggcaag cagaacctgg tcatcatggg tcgcaagacc     4380

tggttctcca tccccgagaa gaaccgtctg ctgaaggacc gtatcaacat cgtgctgtcc     4440

cgcgagctga aggaaccccc tcgtggtgct cacttcctgg ctaagtccct ggacgacgct     4500

ctgcgtctga tcgagcagcc tgagctggct tccaaggtgg acatggtctg gatcgtgggc     4560

ggttcctccg tgtaccaaga ggctatgaac cagcccggtc acttgcgtct gttcgtgacc     4620

cgtatcatgc aagagttcga gtccgacacc ttcttccccg aaatcgacct gggcaagtac     4680

aagctgctgc ccgagtaccc cggtgtcctg tccgaggtgc aagaggaaaa gggtatcaag     4740

tacaagttcg aggtgtacga gaagaaggac ggcgcttccg gtttcgctaa cgagctcggt     4800

cctcgtctga tgggaaaggg cgccggcggt ggtgctggtg ctggaccgat caccatcaac     4860

aacttcaatt actcggatcc ggtggataac aagaacatcc tctacttgga cacacacttg     4920

aacacgctgg ctaacgagcc tgaaaaagct ttcaggatca ccggcaacat ttgggtcatt     4980

ccggataggt tcagcagaaa ctctaaccct aacttgaaca aacctcccag agtgacctca     5040

cctaagagtg gatactacga ccccaactac ctctcgactg actccgataa agaccccttc     5100

ctgaaggaga tcattaaact cttcaagcgc atcaactctc gtgaaattgg cgaggaattg     5160

atctaccgcc tgagtacaga catcccattc ccgggtaaca acaacacccc aatcaacact     5220

ttcgatttcg atgtcgattt caactcagtg gatgtcaaaa ccaggcaggg aaacaactgg     5280

gtgaagactg gtagcatcaa cccatctgtc atcattactg gcccgagaga gaacatcatt     5340

gaccctgaaa cctccacttt caagctgaca aacaacacgt tcgctgctca ggaaggcttc     5400

ggagcgttga gcatcatttc tatctcacct cgcttcatgc tgacatactc taacgctacg     5460

aacgacgtgg gagagggccg tttcagtaag tctgaattct gcatggaccc tattctgatc     5520

ctcatgcacg ctctcaacgg cgccatgcac aacttgtacg gaattgctat ccccaacgac     5580

cagaccattt ccagcgtgac tagcaacatc ttctactctc aatacaacgt caagctggag     5640

tacgcagaaa tctacgcttt cggtggccca accattgact tgatcccgaa atcagctcgt     5700

aagtatttcg aagaaaaagc gctggattat tacaggtcga ttgctaagag actcaactcc     5760

atcaccactg ctaacccctc ttcattcaac aagtacattg gagaatacaa gcagaaactg     5820

atccgcaagt accgtttcgt ggtcgagagt tcgggtgaag ttactgtgaa ccgcaacaag     5880

ttcgtcgagc tgtacaacga attgacacaa atcttcacgg agttcaacta cgccaaaatt     5940

tacaacgtgc aaaaccgtaa gatcgcgctc tctaacgtct acaccccggt taccgctaac     6000

atcttggacg ataacgtcta cgacattcag aacggtttca acatcccaaa gtcgaacctc     6060

aacgttttgt tcatgggtca aaacttgtcc cgcaaccccg ccctgcgtaa ggtgaaccca     6120

gagaacatgt tgtacctgtt caccaaattc tgccacaagg ccatcgacgg tcagtctcta     6180

gaccaaggag gatgggaact ccagcaaggt ggccagggtg gaggtgctgg caccctggac     6240

tgtcgcgaac tgctcgttaa gaacactgat ctcccattca ttggcgacat ctctgatgtg     6300

aaaacagaca ttttcctgcg taaggatatc aacgaggaaa cggaggtcat ctactaccct     6360

gacaacgtct cggttgatca ggttatcttg tcaaagaaca ccagtgaaca tggccaactg     6420

gacttgctgt acccctcaat tgattccgag agcgaaatcc tgccaggaga gaaccaggtt     6480

ttctacgaca acaggacaca aaacgtggat tacctcaaca gctactacta cctggagtcg     6540

cagaagctct ccgacaacgt cgaagatttc acatttacga gatcaatcga ggaggctttg     6600

gacaacagtg ccaaagtcta cacctacttc cctactctgg caaacaaggt gaacgcgggt     6660

gtccaaggcg gactcttctt gatgtgggct aacgacgttg tggaagattt cacaacgaac     6720

atcttgcgca aagacaccct ggataagatc agcgatgtct ctgccatcat tccatacatt     6780

ggcccggcac tgaacatctc taactcagtt cgccgtggca acttcactga ggcattcgcg     6840

gtcacaggag ttacgatcct cttggaggct ttcccggagt tcacaatccc cgcactgggc     6900

gcgttcgtta tctactccaa agtgcaggag cgcaacgaaa tcattaagac tatcgacaac     6960

tgcctggagc aaaggatcaa aagatggaag gattcgtacg aatggatgat gggtacctgg     7020

ctctcccgta tcattacgca gttcaacaac atcagctacc aaatgtacga ctctctcaac     7080

taccaggctg gtgccatcaa ggccaaaatt gacttggagt acaagaaata cagtggctcg     7140

gataaagaga acatcaagag tcaagtcgaa aacctgaaaa actcactcga cgttaagatc     7200

agtgaggcaa tgaacaacat caacaagttc attcgcgaat gttccgttac ctacctcttc     7260

aaaaacatgt tgccaaaggt catcgacgag ctgaacgaat ttgatcgtaa cactaaggcg     7320

aaactgatta acctcatcga ctcacacaac atcattttgg tgggcgaagt cgataagctg     7380

aaagccaagg tgaacaacag tttccagaac acaatccctt tcaacatttt ctcatacacg     7440

aacaacagtc tgctcaagga catcattaac gagtacttca acaacattaa cgatagcaaa     7500

atcctgtcac tgcagaaccg taagaacaca ctggtcgata ctagtggata caacgccgaa     7560

gtctctgagg aaggtgacgt gcagctgaac cctatcttcc ccttcgactt caaattgggc     7620

tccagcggag aggatagggg caaggtcatc gtcacccaga acgagaacat cgtctacaac     7680

tcaatgtacg aatccttcag catctctttc tggatcagga ttaacaagtg ggtgagcaac     7740

ctgcccggtt acacaatcat tgactctgtc aagaacaact caggttggag tatcggcatc     7800

atttctaact tcttggtctt caccctgaag cagaacgagg actcggaaca atccattaac     7860

ttctcatacg atatcagtaa caacgctcca ggttacaaca agtggttctt cgttaccgtg     7920

actaacaaca tgatgggtaa catgaaaatt tacatcaacg gcaagctcat tgacaccatc     7980

aaagtgaagg agttgactgg tattaacttc tccaaaacaa tcacgtttga aattaacaag     8040

atccctgaca ccggcctgat cacttcagac agtgataaca tcaacatgtg gattagggat     8100

ttctacatct tcgccaagga gctcgacgga aaggatatta acatcctctt caacagcttg     8160

cagtacacca acgtcgttaa agactactgg ggtaacgatt tgagatacaa caaggagtac     8220

tacatggtca acatcgacta cctgaacagg tacatgtacg ctaactcccg ccaaatcgtg     8280

ttcaacacca ggagaaacaa caacgacttc aacgagggtt acaaaatcat tatcaagcgc     8340

atccgtggca acaccaacga tactagggtg agaggtggcg acattctgta cttcgatatg     8400

actatcaaca acaaagccta caacttgttc atgaaaaacg agacaatgta cgccgacaac     8460

catagcacgg aggatattta cgcaatcgga ctgagggaac agacaaagga catcaacgat     8520

aacattatct tccagatcca acctatgaac aacacgtact actacgcttc gcaaatcttc     8580

aagtccaact tcaacggaga aaacatttcg ggtatctgtt ccattggcac ataccgcttc     8640

cgtctgggtg gtgactggta tcgtcacaac tacctcgttc ccaccgtgaa gcagggtaac     8700

tacgcttctt tgctggagtc gacttccacg cactggggat tcgttcctgt gtcagagggc     8760

gctggctacc cttacgatgt tcccgactac gctggttggg aactccagca aggtgcagga     8820

tggtcccacc ctcaattcga gaagggtgcc ggatggagtc acccacagtt cgagaaaggc     8880

gctggatgga gtcacccaca gttcgagaaa taattagttg atgcatagtt aattagatag     8940

ctcgaggcat gcggtaccaa gattggatct agatgcatag ttaattagat agctcgaggc     9000

atgcggtacc aagcttgtcg agaagtacta gaggatcata atcagccata ccacatttgt     9060

agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat     9120

gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa     9180

tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc     9240

caaactcatc aatgtatctt atcatgtctg gatctgatca ctgcttgagc ctaggagatc     9300

cgaaccagat aagtgaaatc tagttccaaa ctattttgtc atttttaatt ttcgtattag     9360

cttacgacgc tacacccagt tcccatctat tttgtcactc ttccctaaat aatccttaaa     9420

aactccattt ccacccctcc cagttcccaa ctattttgtc cgcccacagc ggggcatttt     9480

tcttcctgtt atgtttttaa tcaaacatcc tgccaactcc atgtgacaaa ccgtcatctt     9540

cggctacttt ttctctgtca cagaatgaaa atttttctgt catctcttcg ttattaatgt     9600

ttgtaattga ctgaatatca acgcttattt gcagcctgaa tggcgaatgg                9650


<210>  26
<211>  1607
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein

<400>  26

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ala Gly His His His His His His His His His 
            20                  25                  30          


His His Asp Val Gly Trp Glu Leu Gln Arg Arg Pro Leu Asn Cys Ile 
        35                  40                  45              


Val Ala Val Ser Gln Asn Met Gly Ile Gly Lys Asn Gly Asp Leu Pro 
    50                  55                  60                  


Trp Pro Pro Leu Arg Asn Glu Phe Lys Tyr Phe Gln Arg Met Thr Thr 
65                  70                  75                  80  


Thr Ser Ser Val Glu Gly Lys Gln Asn Leu Val Ile Met Gly Arg Lys 
                85                  90                  95      


Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg Leu Leu Lys Asp Arg Ile 
            100                 105                 110         


Asn Ile Val Leu Ser Arg Glu Leu Lys Glu Pro Pro Arg Gly Ala His 
        115                 120                 125             


Phe Leu Ala Lys Ser Leu Asp Asp Ala Leu Arg Leu Ile Glu Gln Pro 
    130                 135                 140                 


Glu Leu Ala Ser Lys Val Asp Met Val Trp Ile Val Gly Gly Ser Ser 
145                 150                 155                 160 


Val Tyr Gln Glu Ala Met Asn Gln Pro Gly His Leu Arg Leu Phe Val 
                165                 170                 175     


Thr Arg Ile Met Gln Glu Phe Glu Ser Asp Thr Phe Phe Pro Glu Ile 
            180                 185                 190         


Asp Leu Gly Lys Tyr Lys Leu Leu Pro Glu Tyr Pro Gly Val Leu Ser 
        195                 200                 205             


Glu Val Gln Glu Glu Lys Gly Ile Lys Tyr Lys Phe Glu Val Tyr Glu 
    210                 215                 220                 


Lys Lys Asp Gly Ala Ser Gly Phe Ala Asn Glu Leu Gly Pro Arg Leu 
225                 230                 235                 240 


Met Gly Lys Gly Ala Gly Gly Gly Ala Gly Ala Gly Pro Ile Thr Ile 
                245                 250                 255     


Asn Asn Phe Asn Tyr Ser Asp Pro Val Asp Asn Lys Asn Ile Leu Tyr 
            260                 265                 270         


Leu Asp Thr His Leu Asn Thr Leu Ala Asn Glu Pro Glu Lys Ala Phe 
        275                 280                 285             


Arg Ile Thr Gly Asn Ile Trp Val Ile Pro Asp Arg Phe Ser Arg Asn 
    290                 295                 300                 


Ser Asn Pro Asn Leu Asn Lys Pro Pro Arg Val Thr Ser Pro Lys Ser 
305                 310                 315                 320 


Gly Tyr Tyr Asp Pro Asn Tyr Leu Ser Thr Asp Ser Asp Lys Asp Pro 
                325                 330                 335     


Phe Leu Lys Glu Ile Ile Lys Leu Phe Lys Arg Ile Asn Ser Arg Glu 
            340                 345                 350         


Ile Gly Glu Glu Leu Ile Tyr Arg Leu Ser Thr Asp Ile Pro Phe Pro 
        355                 360                 365             


Gly Asn Asn Asn Thr Pro Ile Asn Thr Phe Asp Phe Asp Val Asp Phe 
    370                 375                 380                 


Asn Ser Val Asp Val Lys Thr Arg Gln Gly Asn Asn Trp Val Lys Thr 
385                 390                 395                 400 


Gly Ser Ile Asn Pro Ser Val Ile Ile Thr Gly Pro Arg Glu Asn Ile 
                405                 410                 415     


Ile Asp Pro Glu Thr Ser Thr Phe Lys Leu Thr Asn Asn Thr Phe Ala 
            420                 425                 430         


Ala Gln Glu Gly Phe Gly Ala Leu Ser Ile Ile Ser Ile Ser Pro Arg 
        435                 440                 445             


Phe Met Leu Thr Tyr Ser Asn Ala Thr Asn Asp Val Gly Glu Gly Arg 
    450                 455                 460                 


Phe Ser Lys Ser Glu Phe Cys Met Asp Pro Ile Leu Ile Leu Met His 
465                 470                 475                 480 


Ala Leu Asn Gly Ala Met His Asn Leu Tyr Gly Ile Ala Ile Pro Asn 
                485                 490                 495     


Asp Gln Thr Ile Ser Ser Val Thr Ser Asn Ile Phe Tyr Ser Gln Tyr 
            500                 505                 510         


Asn Val Lys Leu Glu Tyr Ala Glu Ile Tyr Ala Phe Gly Gly Pro Thr 
        515                 520                 525             


Ile Asp Leu Ile Pro Lys Ser Ala Arg Lys Tyr Phe Glu Glu Lys Ala 
    530                 535                 540                 


Leu Asp Tyr Tyr Arg Ser Ile Ala Lys Arg Leu Asn Ser Ile Thr Thr 
545                 550                 555                 560 


Ala Asn Pro Ser Ser Phe Asn Lys Tyr Ile Gly Glu Tyr Lys Gln Lys 
                565                 570                 575     


Leu Ile Arg Lys Tyr Arg Phe Val Val Glu Ser Ser Gly Glu Val Thr 
            580                 585                 590         


Val Asn Arg Asn Lys Phe Val Glu Leu Tyr Asn Glu Leu Thr Gln Ile 
        595                 600                 605             


Phe Thr Glu Phe Asn Tyr Ala Lys Ile Tyr Asn Val Gln Asn Arg Lys 
    610                 615                 620                 


Ile Ala Leu Ser Asn Val Tyr Thr Pro Val Thr Ala Asn Ile Leu Asp 
625                 630                 635                 640 


Asp Asn Val Tyr Asp Ile Gln Asn Gly Phe Asn Ile Pro Lys Ser Asn 
                645                 650                 655     


Leu Asn Val Leu Phe Met Gly Gln Asn Leu Ser Arg Asn Pro Ala Leu 
            660                 665                 670         


Arg Lys Val Asn Pro Glu Asn Met Leu Tyr Leu Phe Thr Lys Phe Cys 
        675                 680                 685             


His Lys Ala Ile Asp Gly Gln Ser Leu Asp Gln Gly Gly Trp Glu Leu 
    690                 695                 700                 


Gln Gln Gly Gly Gln Gly Gly Gly Ala Gly Thr Leu Asp Cys Arg Glu 
705                 710                 715                 720 


Leu Leu Val Lys Asn Thr Asp Leu Pro Phe Ile Gly Asp Ile Ser Asp 
                725                 730                 735     


Val Lys Thr Asp Ile Phe Leu Arg Lys Asp Ile Asn Glu Glu Thr Glu 
            740                 745                 750         


Val Ile Tyr Tyr Pro Asp Asn Val Ser Val Asp Gln Val Ile Leu Ser 
        755                 760                 765             


Lys Asn Thr Ser Glu His Gly Gln Leu Asp Leu Leu Tyr Pro Ser Ile 
    770                 775                 780                 


Asp Ser Glu Ser Glu Ile Leu Pro Gly Glu Asn Gln Val Phe Tyr Asp 
785                 790                 795                 800 


Asn Arg Thr Gln Asn Val Asp Tyr Leu Asn Ser Tyr Tyr Tyr Leu Glu 
                805                 810                 815     


Ser Gln Lys Leu Ser Asp Asn Val Glu Asp Phe Thr Phe Thr Arg Ser 
            820                 825                 830         


Ile Glu Glu Ala Leu Asp Asn Ser Ala Lys Val Tyr Thr Tyr Phe Pro 
        835                 840                 845             


Thr Leu Ala Asn Lys Val Asn Ala Gly Val Gln Gly Gly Leu Phe Leu 
    850                 855                 860                 


Met Trp Ala Asn Asp Val Val Glu Asp Phe Thr Thr Asn Ile Leu Arg 
865                 870                 875                 880 


Lys Asp Thr Leu Asp Lys Ile Ser Asp Val Ser Ala Ile Ile Pro Tyr 
                885                 890                 895     


Ile Gly Pro Ala Leu Asn Ile Ser Asn Ser Val Arg Arg Gly Asn Phe 
            900                 905                 910         


Thr Glu Ala Phe Ala Val Thr Gly Val Thr Ile Leu Leu Glu Ala Phe 
        915                 920                 925             


Pro Glu Phe Thr Ile Pro Ala Leu Gly Ala Phe Val Ile Tyr Ser Lys 
    930                 935                 940                 


Val Gln Glu Arg Asn Glu Ile Ile Lys Thr Ile Asp Asn Cys Leu Glu 
945                 950                 955                 960 


Gln Arg Ile Lys Arg Trp Lys Asp Ser Tyr Glu Trp Met Met Gly Thr 
                965                 970                 975     


Trp Leu Ser Arg Ile Ile Thr Gln Phe Asn Asn Ile Ser Tyr Gln Met 
            980                 985                 990         


Tyr Asp Ser Leu Asn Tyr Gln Ala  Gly Ala Ile Lys Ala  Lys Ile Asp 
        995                 1000                 1005             


Leu Glu  Tyr Lys Lys Tyr Ser  Gly Ser Asp Lys Glu  Asn Ile Lys 
    1010                 1015                 1020             


Ser Gln  Val Glu Asn Leu Lys  Asn Ser Leu Asp Val  Lys Ile Ser 
    1025                 1030                 1035             


Glu Ala  Met Asn Asn Ile Asn  Lys Phe Ile Arg Glu  Cys Ser Val 
    1040                 1045                 1050             


Thr Tyr  Leu Phe Lys Asn Met  Leu Pro Lys Val Ile  Asp Glu Leu 
    1055                 1060                 1065             


Asn Glu  Phe Asp Arg Asn Thr  Lys Ala Lys Leu Ile  Asn Leu Ile 
    1070                 1075                 1080             


Asp Ser  His Asn Ile Ile Leu  Val Gly Glu Val Asp  Lys Leu Lys 
    1085                 1090                 1095             


Ala Lys  Val Asn Asn Ser Phe  Gln Asn Thr Ile Pro  Phe Asn Ile 
    1100                 1105                 1110             


Phe Ser  Tyr Thr Asn Asn Ser  Leu Leu Lys Asp Ile  Ile Asn Glu 
    1115                 1120                 1125             


Tyr Phe  Asn Asn Ile Asn Asp  Ser Lys Ile Leu Ser  Leu Gln Asn 
    1130                 1135                 1140             


Arg Lys  Asn Thr Leu Val Asp  Thr Ser Gly Tyr Asn  Ala Glu Val 
    1145                 1150                 1155             


Ser Glu  Glu Gly Asp Val Gln  Leu Asn Pro Ile Phe  Pro Phe Asp 
    1160                 1165                 1170             


Phe Lys  Leu Gly Ser Ser Gly  Glu Asp Arg Gly Lys  Val Ile Val 
    1175                 1180                 1185             


Thr Gln  Asn Glu Asn Ile Val  Tyr Asn Ser Met Tyr  Glu Ser Phe 
    1190                 1195                 1200             


Ser Ile  Ser Phe Trp Ile Arg  Ile Asn Lys Trp Val  Ser Asn Leu 
    1205                 1210                 1215             


Pro Gly  Tyr Thr Ile Ile Asp  Ser Val Lys Asn Asn  Ser Gly Trp 
    1220                 1225                 1230             


Ser Ile  Gly Ile Ile Ser Asn  Phe Leu Val Phe Thr  Leu Lys Gln 
    1235                 1240                 1245             


Asn Glu  Asp Ser Glu Gln Ser  Ile Asn Phe Ser Tyr  Asp Ile Ser 
    1250                 1255                 1260             


Asn Asn  Ala Pro Gly Tyr Asn  Lys Trp Phe Phe Val  Thr Val Thr 
    1265                 1270                 1275             


Asn Asn  Met Met Gly Asn Met  Lys Ile Tyr Ile Asn  Gly Lys Leu 
    1280                 1285                 1290             


Ile Asp  Thr Ile Lys Val Lys  Glu Leu Thr Gly Ile  Asn Phe Ser 
    1295                 1300                 1305             


Lys Thr  Ile Thr Phe Glu Ile  Asn Lys Ile Pro Asp  Thr Gly Leu 
    1310                 1315                 1320             


Ile Thr  Ser Asp Ser Asp Asn  Ile Asn Met Trp Ile  Arg Asp Phe 
    1325                 1330                 1335             


Tyr Ile  Phe Ala Lys Glu Leu  Asp Gly Lys Asp Ile  Asn Ile Leu 
    1340                 1345                 1350             


Phe Asn  Ser Leu Gln Tyr Thr  Asn Val Val Lys Asp  Tyr Trp Gly 
    1355                 1360                 1365             


Asn Asp  Leu Arg Tyr Asn Lys  Glu Tyr Tyr Met Val  Asn Ile Asp 
    1370                 1375                 1380             


Tyr Leu  Asn Arg Tyr Met Tyr  Ala Asn Ser Arg Gln  Ile Val Phe 
    1385                 1390                 1395             


Asn Thr  Arg Arg Asn Asn Asn  Asp Phe Asn Glu Gly  Tyr Lys Ile 
    1400                 1405                 1410             


Ile Ile  Lys Arg Ile Arg Gly  Asn Thr Asn Asp Thr  Arg Val Arg 
    1415                 1420                 1425             


Gly Gly  Asp Ile Leu Tyr Phe  Asp Met Thr Ile Asn  Asn Lys Ala 
    1430                 1435                 1440             


Tyr Asn  Leu Phe Met Lys Asn  Glu Thr Met Tyr Ala  Asp Asn His 
    1445                 1450                 1455             


Ser Thr  Glu Asp Ile Tyr Ala  Ile Gly Leu Arg Glu  Gln Thr Lys 
    1460                 1465                 1470             


Asp Ile  Asn Asp Asn Ile Ile  Phe Gln Ile Gln Pro  Met Asn Asn 
    1475                 1480                 1485             


Thr Tyr  Tyr Tyr Ala Ser Gln  Ile Phe Lys Ser Asn  Phe Asn Gly 
    1490                 1495                 1500             


Glu Asn  Ile Ser Gly Ile Cys  Ser Ile Gly Thr Tyr  Arg Phe Arg 
    1505                 1510                 1515             


Leu Gly  Gly Asp Trp Tyr Arg  His Asn Tyr Leu Val  Pro Thr Val 
    1520                 1525                 1530             


Lys Gln  Gly Asn Tyr Ala Ser  Leu Leu Glu Ser Thr  Ser Thr His 
    1535                 1540                 1545             


Trp Gly  Phe Val Pro Val Ser  Glu Gly Ala Gly Tyr  Pro Tyr Asp 
    1550                 1555                 1560             


Val Pro  Asp Tyr Ala Gly Trp  Glu Leu Gln Gln Gly  Ala Gly Trp 
    1565                 1570                 1575             


Ser His  Pro Gln Phe Glu Lys  Gly Ala Gly Trp Ser  His Pro Gln 
    1580                 1585                 1590             


Phe Glu  Lys Gly Ala Gly Trp  Ser His Pro Gln Phe  Glu Lys 
    1595                 1600                 1605         


<210>  27
<211>  546
<212>  DNA
<213>  Artificial

<220>
<223>  DNA construct for molecular construction of fusion proteins

<400>  27
gacgtcggct gggagctgca aggcgccggc gagcagaaac tcatcagcga agaagatttg       60

ggtgcggccg ctggctcagg aggtggcagt caggcgcacg tgcaactgca gcagtctgga      120

ggaggcttgg tgcagcctgg gggttccctg cgcctgtcat gtgcagcctc tggaagcatc      180

ttcagtattt acgctatggg ctggtacagg caggctcctg gcaagcaacg tgaactggtt      240

gctgccatct ccagctacgg tagtaccaac tacgctgatt cggtcaaggg caggttcacc      300

atctcccgcg acaatgccaa gaataccgtc tatttgcaaa tgaactctct gaaacctgag      360

gatacggccg tctactactg caacgctgac attgctacta tgaccgcggt aggcggattc      420

gactactggg gacagggaac tcaggtgacg gtctcttccg aacctaagac ccctaaaccc      480

caaggggccg gccagggtgc tggtgctgga ccgatcacca tcaacaactt caattactcg      540

gatccg                                                                 546


<210>  28
<211>  182
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein construct

<400>  28

Asp Val Gly Trp Glu Leu Gln Gly Ala Gly Glu Gln Lys Leu Ile Ser 
1               5                   10                  15      


Glu Glu Asp Leu Gly Ala Ala Ala Gly Ser Gly Gly Gly Ser Gln Ala 
            20                  25                  30          


His Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        35                  40                  45              


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Tyr 
    50                  55                  60                  


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
65                  70                  75                  80  


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
                85                  90                  95      


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
            100                 105                 110         


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
        115                 120                 125             


Ala Asp Ile Ala Thr Met Thr Ala Val Gly Gly Phe Asp Tyr Trp Gly 
    130                 135                 140                 


Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro 
145                 150                 155                 160 


Gln Gly Ala Gly Gln Gly Ala Gly Ala Gly Pro Ile Thr Ile Asn Asn 
                165                 170                 175     


Phe Asn Tyr Ser Asp Pro 
            180         


<210>  29
<211>  957
<212>  DNA
<213>  Artificial

<220>
<223>  DNA construct for molecular construction of fusion proteins

<400>  29
gacgtcggct gggagctgca aggcgccggc gagcagaaac tcatcagcga agaagatttg       60

ggtgcggccg ctcaggttca actcgtggag agtggtggcg gactggtgca atccggtggc      120

agcctgaggc tctcctgcgc tgcctctgga tcaatcgaca gcctgtacca catgggttgg      180

tacaggcagg ctcccggcaa ggagagggaa ctcgtcgcca gagttcaaga cggaggtagt      240

acagcataca aggattcggt caaaggtcgc ttcaccattt ctcgcgactt cagtcgttcg      300

actatgtact tgcagatgaa ctcactgaag cctgaggata cagccatcta ctactgtgca      360

gcgaaatcta ccatttcaac tccactgtct tggggccagg gaacacaagt gacggtctcc      420

agcgaaccga agacgcctaa accccaatct tcaggcggag gtgcggccgc ttggctcagg      480

aggtggcagt caactccagc tcgttgagtc cggtggcgga atggtgcaac ctggtggctc      540

tttgaggctg tcatgcgctg cagtggattc accttctcga cttacgacat gtcctgggtg      600

cgtcaggcac ctggaaaagg tcccgaatgg gtcagcatca ttaacgctgg aggtggcagc      660

acatactacg cagcgtctgt taagggaagg ttcgctatct ccagagacaa cgccaaaaac      720

accctctact tgcaaatgaa caacctgaag cccgaggata ctgctctcta ctactgtgct      780

cgcgtcgcct catactactg ccgtggctac gtttgtagtc ctcccgagtt cgactactgg      840

ggccagggaa cacaagtgac ggtctccagc gaaccaaaga caccaaaacc acagggggcc      900

ggccagggtg ctggtgctgg accgatcacc atcaacaact tcaattactc ggatccg         957


<210>  30
<211>  315
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein construct

<400>  30

Asp Val Gly Trp Glu Leu Gln Gly Ala Gly Glu Gln Lys Leu Ile Ser 
1               5                   10                  15      


Glu Glu Asp Leu Gly Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Ser Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Ser Ile Asp Ser Leu Tyr His Met Gly Trp Tyr Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Glu Arg Glu Leu Val Ala Arg Val Gln Asp Gly Gly Ser 
65                  70                  75                  80  


Thr Ala Tyr Lys Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      


Phe Ser Arg Ser Thr Met Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
            100                 105                 110         


Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Lys Ser Thr Ile Ser Thr Pro 
        115                 120                 125             


Leu Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys 
    130                 135                 140                 


Thr Pro Lys Pro Gln Ser Ser Gly Gly Gly Ala Ala Ala Trp Leu Arg 
145                 150                 155                 160 


Arg Trp Gln Ser Thr Pro Ala Arg Val Arg Trp Arg Asn Gly Ala Thr 
                165                 170                 175     


Trp Trp Leu Phe Glu Ala Val Met Arg Cys Gln Trp Ile His Leu Leu 
            180                 185                 190         


Asp Leu Arg His Val Leu Gly Ala Ser Gly Thr Trp Lys Arg Ser Arg 
        195                 200                 205             


Met Gly Gln His His Arg Trp Arg Trp Gln His Ile Leu Arg Ser Val 
    210                 215                 220                 


Cys Gly Lys Val Arg Tyr Leu Gln Arg Gln Arg Gln Lys His Pro Leu 
225                 230                 235                 240 


Leu Ala Asn Glu Gln Pro Glu Ala Arg Gly Tyr Cys Ser Leu Leu Leu 
                245                 250                 255     


Cys Ser Arg Arg Leu Ile Leu Leu Pro Trp Leu Arg Leu Ser Ser Arg 
            260                 265                 270         


Val Arg Leu Leu Gly Pro Gly Asn Thr Ser Asp Gly Leu Gln Arg Thr 
        275                 280                 285             


Lys Asp Thr Lys Thr Thr Gly Gly Arg Pro Gly Cys Trp Cys Trp Thr 
    290                 295                 300                 


Asp His His Gln Gln Leu Gln Leu Leu Gly Ser 
305                 310                 315 


<210>  31
<211>  930
<212>  DNA
<213>  Artificial

<220>
<223>  DNA construct for molecular construction of fusion proteins

<400>  31
gacgtcggct gggagctgca aggcgccggc gagcagaaac tcatcagcga agaagatttg       60

ggtgcggccg ctcaggttca actcgtggag agtggtggcg gactggtgca atccggtggc      120

agcctgaggc tctcctgcgc tgcctctgga tcaatcgaca gcctgtacca catgggttgg      180

tacaggcagg ctcccggcaa ggagagggaa ctcgtcgcca gagttcaaga cggaggtagt      240

acagcataca aggattcggt caaaggtcgc ttcaccattt ctcgcgactt cagtcgttcg      300

actatgtact tgcagatgaa ctcactgaag cctgaggata cagccatcta ctactgtgca      360

gcgaaatcta ccatttcaac tccactgtct tggggccagg gaacacaagt gacggtctcc      420

agcgaaccga agacgcctaa accccaatct tcaggcggag gtgcggccgc tggctcagga      480

ggtggcagtc aggtgcagct ggtggaatcc ggtggtggac tggtccagcc tggtggttcc      540

ctgcgtctgt cctgcgctgc ttccggtttc cccttccacg cttactacat gtcctgggtc      600

cgccaggctc ctggcaaggg attggaatgg gtgtcccaca tcggcaacgg tggtatcatc      660

acccgttacg ctgactccgt gaagggccgt ttcaccatct cccgtgacaa cgctaagaac      720

accctgtacc tgcagatgac caacctgaag cccgaggaca ccgctctgta ctactgcacc      780

ctgggcaccc gtgacgacct gggtcctgaa cgtggccagg gaacccaagt gaccgtgtcc      840

tccgagccca agacccccaa gcctcaaggg gccggccagg gtgctggtgc tggaccgatc      900

accatcaaca acttcaatta ctcggatccg                                       930


<210>  32
<211>  310
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein construct

<400>  32

Asp Val Gly Trp Glu Leu Gln Gly Ala Gly Glu Gln Lys Leu Ile Ser 
1               5                   10                  15      


Glu Glu Asp Leu Gly Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Ser Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Ser Ile Asp Ser Leu Tyr His Met Gly Trp Tyr Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Glu Arg Glu Leu Val Ala Arg Val Gln Asp Gly Gly Ser 
65                  70                  75                  80  


Thr Ala Tyr Lys Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      


Phe Ser Arg Ser Thr Met Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
            100                 105                 110         


Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Lys Ser Thr Ile Ser Thr Pro 
        115                 120                 125             


Leu Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys 
    130                 135                 140                 


Thr Pro Lys Pro Gln Ser Ser Gly Gly Gly Ala Ala Ala Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
                165                 170                 175     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe 
            180                 185                 190         


His Ala Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        195                 200                 205             


Glu Trp Val Ser His Ile Gly Asn Gly Gly Ile Ile Thr Arg Tyr Ala 
    210                 215                 220                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
225                 230                 235                 240 


Thr Leu Tyr Leu Gln Met Thr Asn Leu Lys Pro Glu Asp Thr Ala Leu 
                245                 250                 255     


Tyr Tyr Cys Thr Leu Gly Thr Arg Asp Asp Leu Gly Pro Glu Arg Gly 
            260                 265                 270         


Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro 
        275                 280                 285             


Gln Gly Ala Gly Gln Gly Ala Gly Ala Gly Pro Ile Thr Ile Asn Asn 
    290                 295                 300                 


Phe Asn Tyr Ser Asp Pro 
305                 310 


<210>  33
<211>  891
<212>  DNA
<213>  Artificial

<220>
<223>  DNA construct for molecular construction of fusion proteins

<400>  33
gacgtcggct gggagctgca aggcgccggc ggtgcggccg ctcaggttca gttggtggaa       60

tcaggcggcg gctcagttca agcaggcggt tcactcaggc tctcgtgtgc ggcaagcggt      120

atcgactcgt ccagctactg catgggatgg ttcaggcaaa ggccaggaaa ggagagggaa      180

ggtgttgctc gtatcaacgg actgggtggc gttaagacag catacgcgga cagtgtgaaa      240

gataggttca caatttcgag agacaacgca gagaacacgg tctacttgca gatgaactct      300

ctgaagcccg aagatacggc gatctactac tgcgctgcca aattctcacc cggatactgt      360

ggaggtagct ggtctaactt cggttactgg ggtcaaggca cccaagtgac tgtctcttca      420

ggcggaggtg cggccgctgg ctcaggaggt ggcagtcagg tgcagctgca ggagtcggga      480

ggtggctccg tccaagcagg aggtagcctg cgcctctctt gcgcagcgtc aggtatcgac      540

agttcgtcct actgtatggg ctggttcagg cagcgtcctg gcaaggagag ggaaggagtg      600

gcacgtatca acggtctcgg cggagtcaag acagcttacg ccgactccgt taaagatagg      660

ttcaccatta gccgcgacaa cgctgagaac actgtctacc tccaaatgaa cagtttgaag      720

ccggaagata ctgccattta ctactgtgct gccaaattct caccgggcta ctgtggagga      780

agctggtcta acttcggcta ctggggacaa ggaactcaag tcaccgttgg ggccggccag      840

ggtgctggtg ctggaccgat caccatcaac aacttcaatt actcggatcc g               891


<210>  34
<211>  297
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein construct

<400>  34

Asp Val Gly Trp Glu Leu Gln Gly Ala Gly Gly Ala Ala Ala Gln Val 
1               5                   10                  15      


Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu 
            20                  25                  30          


Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Ser Ser Ser Tyr Cys Met 
        35                  40                  45              


Gly Trp Phe Arg Gln Arg Pro Gly Lys Glu Arg Glu Gly Val Ala Arg 
    50                  55                  60                  


Ile Asn Gly Leu Gly Gly Val Lys Thr Ala Tyr Ala Asp Ser Val Lys 
65                  70                  75                  80  


Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Val Tyr Leu 
                85                  90                  95      


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
            100                 105                 110         


Ala Lys Phe Ser Pro Gly Tyr Cys Gly Gly Ser Trp Ser Asn Phe Gly 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ala 
    130                 135                 140                 


Ala Ala Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                165                 170                 175     


Ser Gly Ile Asp Ser Ser Ser Tyr Cys Met Gly Trp Phe Arg Gln Arg 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Gly Val Ala Arg Ile Asn Gly Leu Gly Gly 
        195                 200                 205             


Val Lys Thr Ala Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
    210                 215                 220                 


Arg Asp Asn Ala Glu Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys 
225                 230                 235                 240 


Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Lys Phe Ser Pro Gly 
                245                 250                 255     


Tyr Cys Gly Gly Ser Trp Ser Asn Phe Gly Tyr Trp Gly Gln Gly Thr 
            260                 265                 270         


Gln Val Thr Val Gly Ala Gly Gln Gly Ala Gly Ala Gly Pro Ile Thr 
        275                 280                 285             


Ile Asn Asn Phe Asn Tyr Ser Asp Pro 
    290                 295         


<210>  35
<211>  9506
<212>  DNA
<213>  Artificial

<220>
<223>  DNA construct for molecular construction of fusion proteins

<400>  35
gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc       60

gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc      120

acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt      180

agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg      240

ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt      300

ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta      360

taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt      420

aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt tcggggaaat      480

gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg      540

agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa      600

catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac      660

ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac      720

atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt      780

ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc      840

gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca      900

ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc      960

ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag     1020

gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa     1080

ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg     1140

gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa     1200

ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg     1260

gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt     1320

gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt     1380

caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag     1440

cattggtaac tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat     1500

ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct     1560

taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct     1620

tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca     1680

gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc     1740

agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc     1800

aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct     1860

gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag     1920

gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc     1980

tacaccgaac tgagatacct acagcgtgag cattgagaaa gcgccacgct tcccgaaggg     2040

agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag     2100

cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt     2160

gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac     2220

gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg     2280

ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc     2340

cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcctgatg     2400

cggtattttc tccttacgca tctgtgcggt atttcacacc gcagaccagc cgcgtaacct     2460

ggcaaaatcg gttacggttg agtaataaat ggatgccctg cgtaagcggg tgtgggcgga     2520

caataaagtc ttaaactgaa caaaatagat ctaaactatg acaataaagt cttaaactag     2580

acagaatagt tgtaaactga aatcagtcca gttatgctgt gaaaaagcat actggacttt     2640

tgttatggct aaagcaaact cttcattttc tgaagtgcaa attgcccgtc gtattaaaga     2700

ggggcgtggc caagggcatg gtaaagacta tattcgcggc gttgtgacaa tttaccgaac     2760

aactccgcgg ccgggaagcc gatctcggct tgaacgaatt gttaggtggc ggtacttggg     2820

tcgatatcaa agtgcatcac ttcttcccgt atgcccaact ttgtatagag agccactgcg     2880

ggatcgtcac cgtaatctgc ttgcacgtag atcacataag caccaagcgc gttggcctca     2940

tgcttgagga gattgatgag cgcggtggca atgccctgcc tccggtgctc gccggagact     3000

gcgagatcat agatatagat ctcactacgc ggctgctcaa acctgggcag aacgtaagcc     3060

gcgagagcgc caacaaccgc ttcttggtcg aaggcagcaa gcgcgatgaa tgtcttacta     3120

cggagcaagt tcccgaggta atcggagtcc ggctgatgtt gggagtaggt ggctacgtct     3180

ccgaactcac gaccgaaaag atcaagagca gcccgcatgg atttgacttg gtcagggccg     3240

agcctacatg tgcgaatgat gcccatactt gagccaccta actttgtttt agggcgactg     3300

ccctgctgcg taacatcgtt gctgctgcgt aacatcgttg ctgctccata acatcaaaca     3360

tcgacccacg gcgtaacgcg cttgctgctt ggatgcccga ggcatagact gtacaaaaaa     3420

acagtcataa caagccatga aaaccgccac tgcgccgtta ccaccgctgc gttcggtcaa     3480

ggttctggac cagttgcgtg agcgcatacg ctacttgcat tacagtttac gaaccgaaca     3540

ggcttatgtc aactgggttc gtgccttcat ccgtttccac ggtgtgcgtc acccggcaac     3600

cttgggcagc agcgaagtcg aggcatttct gtcctggctg gcgaacgagc gcaaggtttc     3660

ggtctccacg catcgtcagg cattggcggc cttgctgttc ttctacggca aggtgctgtg     3720

cacggatctg ccctggcttc aggagatcgg aagacctcgg ccgtcgcggc gcttgccggt     3780

ggtgctgacc ccggatgaag tggttcgcat cctcggtttt ctggaaggcg agcatcgttt     3840

gttcgcccag gactctagct atagttctag tggttggcta cgtatactcc ggaatattaa     3900

tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt     3960

ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca     4020

ccatcgggcg cggatctcgg tccgttcgaa ccagaactct ggaagcttaa ctcctaaaaa     4080

accgccacca tgaaattctt agtcaacgtt gcccttgttt ttatggtcgt atacatttct     4140

tacatctatg cggccggaca ccaccaccac caccaccacc accaccacca cgacgtcggc     4200

tgggagctgc aaggcgccgg cgagcagaaa ctcatcagcg aagaagattt gggtgcggcc     4260

gctggctcag gaggtggcag tcaggcgcac gtgcaactgc agcagtctgg aggaggcttg     4320

gtgcagcctg ggggttccct gcgcctgtca tgtgcagcct ctggaagcat cttcagtatt     4380

tacgctatgg gctggtacag gcaggctcct ggcaagcaac gtgaactggt tgctgccatc     4440

tccagctacg gtagtaccaa ctacgctgat tcggtcaagg gcaggttcac catctcccgc     4500

gacaatgcca agaataccgt ctatttgcaa atgaactctc tgaaacctga ggatacggcc     4560

gtctactact gcaacgctga cattgctact atgaccgcgg taggcggatt cgactactgg     4620

ggacagggaa ctcaggtgac ggtctcttcc gaacctaaga cccctaaacc ccaaggggcc     4680

ggccagggtg ctggtgctgg accgatcacc atcaacaact tcaattactc ggatccggtg     4740

gataacaaga acatcctcta cttggacaca cacttgaaca cgctggctaa cgagcctgaa     4800

aaagctttca ggatcaccgg caacatttgg gtcattccgg ataggttcag cagaaactct     4860

aaccctaact tgaacaaacc tcccagagtg acctcaccta agagtggata ctacgacccc     4920

aactacctct cgactgactc cgataaagac cccttcctga aggagatcat taaactcttc     4980

aagcgcatca actctcgtga aattggcgag gaattgatct accgcctgag tacagacatc     5040

ccattcccgg gtaacaacaa caccccaatc aacactttcg atttcgatgt cgatttcaac     5100

tcagtggatg tcaaaaccag gcagggaaac aactgggtga agactggtag catcaaccca     5160

tctgtcatca ttactggccc gagagagaac atcattgacc ctgaaacctc cactttcaag     5220

ctgacaaaca acacgttcgc tgctcaggaa ggcttcggag cgttgagcat catttctatc     5280

tcacctcgct tcatgctgac atactctaac gctacgaacg acgtgggaga gggccgtttc     5340

agtaagtctg aattctgcat ggaccctatt ctgatcctca tgcacgctct caacggcgcc     5400

atgcacaact tgtacggaat tgctatcccc aacgaccaga ccatttccag cgtgactagc     5460

aacatcttct actctcaata caacgtcaag ctggagtacg cagaaatcta cgctttcggt     5520

ggcccaacca ttgacttgat cccgaaatca gctcgtaagt atttcgaaga aaaagcgctg     5580

gattattaca ggtcgattgc taagagactc aactccatca ccactgctaa cccctcttca     5640

ttcaacaagt acattggaga atacaagcag aaactgatcc gcaagtaccg tttcgtggtc     5700

gagagttcgg gtgaagttac tgtgaaccgc aacaagttcg tcgagctgta caacgaattg     5760

acacaaatct tcacggagtt caactacgcc aaaatttaca acgtgcaaaa ccgtaagatc     5820

gcgctctcta acgtctacac cccggttacc gctaacatct tggacgataa cgtctacgac     5880

attcagaacg gtttcaacat cccaaagtcg aacctcaacg ttttgttcat gggtcaaaac     5940

ttgtcccgca accccgccct gcgtaaggtg aacccagaga acatgttgta cctgttcacc     6000

aaattctgcc acaaggccat cgacggtcag tctctagacc aaggaggatg ggaactccag     6060

caaggtggcc agggtggagg tgctggcacc ctggactgtc gcgaactgct cgttaagaac     6120

actgatctcc cattcattgg cgacatctct gatgtgaaaa cagacatttt cctgcgtaag     6180

gatatcaacg aggaaacgga ggtcatctac taccctgaca acgtctcggt tgatcaggtt     6240

atcttgtcaa agaacaccag tgaacatggc caactggact tgctgtaccc ctcaattgat     6300

tccgagagcg aaatcctgcc aggagagaac caggttttct acgacaacag gacacaaaac     6360

gtggattacc tcaacagcta ctactacctg gagtcgcaga agctctccga caacgtcgaa     6420

gatttcacat ttacgagatc aatcgaggag gctttggaca acagtgccaa agtctacacc     6480

tacttcccta ctctggcaaa caaggtgaac gcgggtgtcc aaggcggact cttcttgatg     6540

tgggctaacg acgttgtgga agatttcaca acgaacatct tgcgcaaaga caccctggat     6600

aagatcagcg atgtctctgc catcattcca tacattggcc cggcactgaa catctctaac     6660

tcagttcgcc gtggcaactt cactgaggca ttcgcggtca caggagttac gatcctcttg     6720

gaggctttcc cggagttcac aatccccgca ctgggcgcgt tcgttatcta ctccaaagtg     6780

caggagcgca acgaaatcat taagactatc gacaactgcc tggagcaaag gatcaaaaga     6840

tggaaggatt cgtacgaatg gatgatgggt acctggctct cccgtatcat tacgcagttc     6900

aacaacatca gctaccaaat gtacgactct ctcaactacc aggctggtgc catcaaggcc     6960

aaaattgact tggagtacaa gaaatacagt ggctcggata aagagaacat caagagtcaa     7020

gtcgaaaacc tgaaaaactc actcgacgtt aagatcagtg aggcaatgaa caacatcaac     7080

aagttcattc gcgaatgttc cgttacctac ctcttcaaaa acatgttgcc aaaggtcatc     7140

gacgagctga acgaatttga tcgtaacact aaggcgaaac tgattaacct catcgactca     7200

cacaacatca ttttggtggg cgaagtcgat aagctgaaag ccaaggtgaa caacagtttc     7260

cagaacacaa tccctttcaa cattttctca tacacgaaca acagtctgct caaggacatc     7320

attaacgagt acttcaacaa cattaacgat agcaaaatcc tgtcactgca gaaccgtaag     7380

aacacactgg tcgatactag tggatacaac gccgaagtct ctgaggaagg tgacgtgcag     7440

ctgaacccta tcttcccctt cgacttcaaa ttgggctcca gcggagagga taggggcaag     7500

gtcatcgtca cccagaacga gaacatcgtc tacaactcaa tgtacgaatc cttcagcatc     7560

tctttctgga tcaggattaa caagtgggtg agcaacctgc ccggttacac aatcattgac     7620

tctgtcaaga acaactcagg ttggagtatc ggcatcattt ctaacttctt ggtcttcacc     7680

ctgaagcaga acgaggactc ggaacaatcc attaacttct catacgatat cagtaacaac     7740

gctccaggtt acaacaagtg gttcttcgtt accgtgacta acaacatgat gggtaacatg     7800

aaaatttaca tcaacggcaa gctcattgac accatcaaag tgaaggagtt gactggtatt     7860

aacttctcca aaacaatcac gtttgaaatt aacaagatcc ctgacaccgg cctgatcact     7920

tcagacagtg ataacatcaa catgtggatt agggatttct acatcttcgc caaggagctc     7980

gacggaaagg atattaacat cctcttcaac agcttgcagt acaccaacgt cgttaaagac     8040

tactggggta acgatttgag atacaacaag gagtactaca tggtcaacat cgactacctg     8100

aacaggtaca tgtacgctaa ctcccgccaa atcgtgttca acaccaggag aaacaacaac     8160

gacttcaacg agggttacaa aatcattatc aagcgcatcc gtggcaacac caacgatact     8220

agggtgagag gtggcgacat tctgtacttc gatatgacta tcaacaacaa agcctacaac     8280

ttgttcatga aaaacgagac aatgtacgcc gacaaccata gcacggagga tatttacgca     8340

atcggactga gggaacagac aaaggacatc aacgataaca ttatcttcca gatccaacct     8400

atgaacaaca cgtactacta cgcttcgcaa atcttcaagt ccaacttcaa cggagaaaac     8460

atttcgggta tctgttccat tggcacatac cgcttccgtc tgggtggtga ctggtatcgt     8520

cacaactacc tcgttcccac cgtgaagcag ggtaactacg cttctttgct ggagtcgact     8580

tccacgcact ggggattcgt tcctgtgtca gagggcgctg gctaccctta cgatgttccc     8640

gactacgctg gttgggaact ccagcaaggt gcaggatggt cccaccctca attcgagaag     8700

ggtgccggat ggagtcaccc acagttcgag aaaggcgctg gatggagtca cccacagttc     8760

gagaaataat tagttgatgc atagttaatt agatagctcg aggcatgcgg taccaagatt     8820

ggatctagat gcatagttaa ttagatagct cgaggcatgc ggtaccaagc ttgtcgagaa     8880

gtactagagg atcataatca gccataccac atttgtagag gttttacttg ctttaaaaaa     8940

cctcccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg ttgttaactt     9000

gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa     9060

agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca     9120

tgtctggatc tgatcactgc ttgagcctag gagatccgaa ccagataagt gaaatctagt     9180

tccaaactat tttgtcattt ttaattttcg tattagctta cgacgctaca cccagttccc     9240

atctattttg tcactcttcc ctaaataatc cttaaaaact ccatttccac ccctcccagt     9300

tcccaactat tttgtccgcc cacagcgggg catttttctt cctgttatgt ttttaatcaa     9360

acatcctgcc aactccatgt gacaaaccgt catcttcggc tactttttct ctgtcacaga     9420

atgaaaattt ttctgtcatc tcttcgttat taatgtttgt aattgactga atatcaacgc     9480

ttatttgcag cctgaatggc gaatgg                                          9506


<210>  36
<211>  1559
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein construct

<400>  36

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ala Gly His His His His His His His His His 
            20                  25                  30          


His His Asp Val Gly Trp Glu Leu Gln Gly Ala Gly Glu Gln Lys Leu 
        35                  40                  45              


Ile Ser Glu Glu Asp Leu Gly Ala Ala Ala Gly Ser Gly Gly Gly Ser 
    50                  55                  60                  


Gln Ala His Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro 
65                  70                  75                  80  


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser 
                85                  90                  95      


Ile Tyr Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
            100                 105                 110         


Leu Val Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asn Tyr Ala Asp Ser 
        115                 120                 125             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
    130                 135                 140                 


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
145                 150                 155                 160 


Cys Asn Ala Asp Ile Ala Thr Met Thr Ala Val Gly Gly Phe Asp Tyr 
                165                 170                 175     


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro 
            180                 185                 190         


Lys Pro Gln Gly Ala Gly Gln Gly Ala Gly Ala Gly Pro Ile Thr Ile 
        195                 200                 205             


Asn Asn Phe Asn Tyr Ser Asp Pro Val Asp Asn Lys Asn Ile Leu Tyr 
    210                 215                 220                 


Leu Asp Thr His Leu Asn Thr Leu Ala Asn Glu Pro Glu Lys Ala Phe 
225                 230                 235                 240 


Arg Ile Thr Gly Asn Ile Trp Val Ile Pro Asp Arg Phe Ser Arg Asn 
                245                 250                 255     


Ser Asn Pro Asn Leu Asn Lys Pro Pro Arg Val Thr Ser Pro Lys Ser 
            260                 265                 270         


Gly Tyr Tyr Asp Pro Asn Tyr Leu Ser Thr Asp Ser Asp Lys Asp Pro 
        275                 280                 285             


Phe Leu Lys Glu Ile Ile Lys Leu Phe Lys Arg Ile Asn Ser Arg Glu 
    290                 295                 300                 


Ile Gly Glu Glu Leu Ile Tyr Arg Leu Ser Thr Asp Ile Pro Phe Pro 
305                 310                 315                 320 


Gly Asn Asn Asn Thr Pro Ile Asn Thr Phe Asp Phe Asp Val Asp Phe 
                325                 330                 335     


Asn Ser Val Asp Val Lys Thr Arg Gln Gly Asn Asn Trp Val Lys Thr 
            340                 345                 350         


Gly Ser Ile Asn Pro Ser Val Ile Ile Thr Gly Pro Arg Glu Asn Ile 
        355                 360                 365             


Ile Asp Pro Glu Thr Ser Thr Phe Lys Leu Thr Asn Asn Thr Phe Ala 
    370                 375                 380                 


Ala Gln Glu Gly Phe Gly Ala Leu Ser Ile Ile Ser Ile Ser Pro Arg 
385                 390                 395                 400 


Phe Met Leu Thr Tyr Ser Asn Ala Thr Asn Asp Val Gly Glu Gly Arg 
                405                 410                 415     


Phe Ser Lys Ser Glu Phe Cys Met Asp Pro Ile Leu Ile Leu Met His 
            420                 425                 430         


Ala Leu Asn Gly Ala Met His Asn Leu Tyr Gly Ile Ala Ile Pro Asn 
        435                 440                 445             


Asp Gln Thr Ile Ser Ser Val Thr Ser Asn Ile Phe Tyr Ser Gln Tyr 
    450                 455                 460                 


Asn Val Lys Leu Glu Tyr Ala Glu Ile Tyr Ala Phe Gly Gly Pro Thr 
465                 470                 475                 480 


Ile Asp Leu Ile Pro Lys Ser Ala Arg Lys Tyr Phe Glu Glu Lys Ala 
                485                 490                 495     


Leu Asp Tyr Tyr Arg Ser Ile Ala Lys Arg Leu Asn Ser Ile Thr Thr 
            500                 505                 510         


Ala Asn Pro Ser Ser Phe Asn Lys Tyr Ile Gly Glu Tyr Lys Gln Lys 
        515                 520                 525             


Leu Ile Arg Lys Tyr Arg Phe Val Val Glu Ser Ser Gly Glu Val Thr 
    530                 535                 540                 


Val Asn Arg Asn Lys Phe Val Glu Leu Tyr Asn Glu Leu Thr Gln Ile 
545                 550                 555                 560 


Phe Thr Glu Phe Asn Tyr Ala Lys Ile Tyr Asn Val Gln Asn Arg Lys 
                565                 570                 575     


Ile Ala Leu Ser Asn Val Tyr Thr Pro Val Thr Ala Asn Ile Leu Asp 
            580                 585                 590         


Asp Asn Val Tyr Asp Ile Gln Asn Gly Phe Asn Ile Pro Lys Ser Asn 
        595                 600                 605             


Leu Asn Val Leu Phe Met Gly Gln Asn Leu Ser Arg Asn Pro Ala Leu 
    610                 615                 620                 


Arg Lys Val Asn Pro Glu Asn Met Leu Tyr Leu Phe Thr Lys Phe Cys 
625                 630                 635                 640 


His Lys Ala Ile Asp Gly Gln Ser Leu Asp Gln Gly Gly Trp Glu Leu 
                645                 650                 655     


Gln Gln Gly Gly Gln Gly Gly Gly Ala Gly Thr Leu Asp Cys Arg Glu 
            660                 665                 670         


Leu Leu Val Lys Asn Thr Asp Leu Pro Phe Ile Gly Asp Ile Ser Asp 
        675                 680                 685             


Val Lys Thr Asp Ile Phe Leu Arg Lys Asp Ile Asn Glu Glu Thr Glu 
    690                 695                 700                 


Val Ile Tyr Tyr Pro Asp Asn Val Ser Val Asp Gln Val Ile Leu Ser 
705                 710                 715                 720 


Lys Asn Thr Ser Glu His Gly Gln Leu Asp Leu Leu Tyr Pro Ser Ile 
                725                 730                 735     


Asp Ser Glu Ser Glu Ile Leu Pro Gly Glu Asn Gln Val Phe Tyr Asp 
            740                 745                 750         


Asn Arg Thr Gln Asn Val Asp Tyr Leu Asn Ser Tyr Tyr Tyr Leu Glu 
        755                 760                 765             


Ser Gln Lys Leu Ser Asp Asn Val Glu Asp Phe Thr Phe Thr Arg Ser 
    770                 775                 780                 


Ile Glu Glu Ala Leu Asp Asn Ser Ala Lys Val Tyr Thr Tyr Phe Pro 
785                 790                 795                 800 


Thr Leu Ala Asn Lys Val Asn Ala Gly Val Gln Gly Gly Leu Phe Leu 
                805                 810                 815     


Met Trp Ala Asn Asp Val Val Glu Asp Phe Thr Thr Asn Ile Leu Arg 
            820                 825                 830         


Lys Asp Thr Leu Asp Lys Ile Ser Asp Val Ser Ala Ile Ile Pro Tyr 
        835                 840                 845             


Ile Gly Pro Ala Leu Asn Ile Ser Asn Ser Val Arg Arg Gly Asn Phe 
    850                 855                 860                 


Thr Glu Ala Phe Ala Val Thr Gly Val Thr Ile Leu Leu Glu Ala Phe 
865                 870                 875                 880 


Pro Glu Phe Thr Ile Pro Ala Leu Gly Ala Phe Val Ile Tyr Ser Lys 
                885                 890                 895     


Val Gln Glu Arg Asn Glu Ile Ile Lys Thr Ile Asp Asn Cys Leu Glu 
            900                 905                 910         


Gln Arg Ile Lys Arg Trp Lys Asp Ser Tyr Glu Trp Met Met Gly Thr 
        915                 920                 925             


Trp Leu Ser Arg Ile Ile Thr Gln Phe Asn Asn Ile Ser Tyr Gln Met 
    930                 935                 940                 


Tyr Asp Ser Leu Asn Tyr Gln Ala Gly Ala Ile Lys Ala Lys Ile Asp 
945                 950                 955                 960 


Leu Glu Tyr Lys Lys Tyr Ser Gly Ser Asp Lys Glu Asn Ile Lys Ser 
                965                 970                 975     


Gln Val Glu Asn Leu Lys Asn Ser Leu Asp Val Lys Ile Ser Glu Ala 
            980                 985                 990         


Met Asn Asn Ile Asn Lys Phe Ile  Arg Glu Cys Ser Val  Thr Tyr Leu 
        995                 1000                 1005             


Phe Lys  Asn Met Leu Pro Lys  Val Ile Asp Glu Leu  Asn Glu Phe 
    1010                 1015                 1020             


Asp Arg  Asn Thr Lys Ala Lys  Leu Ile Asn Leu Ile  Asp Ser His 
    1025                 1030                 1035             


Asn Ile  Ile Leu Val Gly Glu  Val Asp Lys Leu Lys  Ala Lys Val 
    1040                 1045                 1050             


Asn Asn  Ser Phe Gln Asn Thr  Ile Pro Phe Asn Ile  Phe Ser Tyr 
    1055                 1060                 1065             


Thr Asn  Asn Ser Leu Leu Lys  Asp Ile Ile Asn Glu  Tyr Phe Asn 
    1070                 1075                 1080             


Asn Ile  Asn Asp Ser Lys Ile  Leu Ser Leu Gln Asn  Arg Lys Asn 
    1085                 1090                 1095             


Thr Leu  Val Asp Thr Ser Gly  Tyr Asn Ala Glu Val  Ser Glu Glu 
    1100                 1105                 1110             


Gly Asp  Val Gln Leu Asn Pro  Ile Phe Pro Phe Asp  Phe Lys Leu 
    1115                 1120                 1125             


Gly Ser  Ser Gly Glu Asp Arg  Gly Lys Val Ile Val  Thr Gln Asn 
    1130                 1135                 1140             


Glu Asn  Ile Val Tyr Asn Ser  Met Tyr Glu Ser Phe  Ser Ile Ser 
    1145                 1150                 1155             


Phe Trp  Ile Arg Ile Asn Lys  Trp Val Ser Asn Leu  Pro Gly Tyr 
    1160                 1165                 1170             


Thr Ile  Ile Asp Ser Val Lys  Asn Asn Ser Gly Trp  Ser Ile Gly 
    1175                 1180                 1185             


Ile Ile  Ser Asn Phe Leu Val  Phe Thr Leu Lys Gln  Asn Glu Asp 
    1190                 1195                 1200             


Ser Glu  Gln Ser Ile Asn Phe  Ser Tyr Asp Ile Ser  Asn Asn Ala 
    1205                 1210                 1215             


Pro Gly  Tyr Asn Lys Trp Phe  Phe Val Thr Val Thr  Asn Asn Met 
    1220                 1225                 1230             


Met Gly  Asn Met Lys Ile Tyr  Ile Asn Gly Lys Leu  Ile Asp Thr 
    1235                 1240                 1245             


Ile Lys  Val Lys Glu Leu Thr  Gly Ile Asn Phe Ser  Lys Thr Ile 
    1250                 1255                 1260             


Thr Phe  Glu Ile Asn Lys Ile  Pro Asp Thr Gly Leu  Ile Thr Ser 
    1265                 1270                 1275             


Asp Ser  Asp Asn Ile Asn Met  Trp Ile Arg Asp Phe  Tyr Ile Phe 
    1280                 1285                 1290             


Ala Lys  Glu Leu Asp Gly Lys  Asp Ile Asn Ile Leu  Phe Asn Ser 
    1295                 1300                 1305             


Leu Gln  Tyr Thr Asn Val Val  Lys Asp Tyr Trp Gly  Asn Asp Leu 
    1310                 1315                 1320             


Arg Tyr  Asn Lys Glu Tyr Tyr  Met Val Asn Ile Asp  Tyr Leu Asn 
    1325                 1330                 1335             


Arg Tyr  Met Tyr Ala Asn Ser  Arg Gln Ile Val Phe  Asn Thr Arg 
    1340                 1345                 1350             


Arg Asn  Asn Asn Asp Phe Asn  Glu Gly Tyr Lys Ile  Ile Ile Lys 
    1355                 1360                 1365             


Arg Ile  Arg Gly Asn Thr Asn  Asp Thr Arg Val Arg  Gly Gly Asp 
    1370                 1375                 1380             


Ile Leu  Tyr Phe Asp Met Thr  Ile Asn Asn Lys Ala  Tyr Asn Leu 
    1385                 1390                 1395             


Phe Met  Lys Asn Glu Thr Met  Tyr Ala Asp Asn His  Ser Thr Glu 
    1400                 1405                 1410             


Asp Ile  Tyr Ala Ile Gly Leu  Arg Glu Gln Thr Lys  Asp Ile Asn 
    1415                 1420                 1425             


Asp Asn  Ile Ile Phe Gln Ile  Gln Pro Met Asn Asn  Thr Tyr Tyr 
    1430                 1435                 1440             


Tyr Ala  Ser Gln Ile Phe Lys  Ser Asn Phe Asn Gly  Glu Asn Ile 
    1445                 1450                 1455             


Ser Gly  Ile Cys Ser Ile Gly  Thr Tyr Arg Phe Arg  Leu Gly Gly 
    1460                 1465                 1470             


Asp Trp  Tyr Arg His Asn Tyr  Leu Val Pro Thr Val  Lys Gln Gly 
    1475                 1480                 1485             


Asn Tyr  Ala Ser Leu Leu Glu  Ser Thr Ser Thr His  Trp Gly Phe 
    1490                 1495                 1500             


Val Pro  Val Ser Glu Gly Ala  Gly Tyr Pro Tyr Asp  Val Pro Asp 
    1505                 1510                 1515             


Tyr Ala  Gly Trp Glu Leu Gln  Gln Gly Ala Gly Trp  Ser His Pro 
    1520                 1525                 1530             


Gln Phe  Glu Lys Gly Ala Gly  Trp Ser His Pro Gln  Phe Glu Lys 
    1535                 1540                 1545             


Gly Ala  Gly Trp Ser His Pro  Gln Phe Glu Lys 
    1550                 1555                 


<210>  37
<211>  10112
<212>  DNA
<213>  Artificial

<220>
<223>  DNA construct for molecular construction of fusion proteins

<400>  37
gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc       60

gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc      120

acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt      180

agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg      240

ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt      300

ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta      360

taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt      420

aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt tcggggaaat      480

gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg      540

agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa      600

catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac      660

ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac      720

atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt      780

ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc      840

gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca      900

ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc      960

ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag     1020

gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa     1080

ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg     1140

gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa     1200

ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg     1260

gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt     1320

gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt     1380

caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag     1440

cattggtaac tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat     1500

ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct     1560

taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct     1620

tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca     1680

gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc     1740

agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc     1800

aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct     1860

gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag     1920

gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc     1980

tacaccgaac tgagatacct acagcgtgag cattgagaaa gcgccacgct tcccgaaggg     2040

agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag     2100

cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt     2160

gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac     2220

gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg     2280

ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc     2340

cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcctgatg     2400

cggtattttc tccttacgca tctgtgcggt atttcacacc gcagaccagc cgcgtaacct     2460

ggcaaaatcg gttacggttg agtaataaat ggatgccctg cgtaagcggg tgtgggcgga     2520

caataaagtc ttaaactgaa caaaatagat ctaaactatg acaataaagt cttaaactag     2580

acagaatagt tgtaaactga aatcagtcca gttatgctgt gaaaaagcat actggacttt     2640

tgttatggct aaagcaaact cttcattttc tgaagtgcaa attgcccgtc gtattaaaga     2700

ggggcgtggc caagggcatg gtaaagacta tattcgcggc gttgtgacaa tttaccgaac     2760

aactccgcgg ccgggaagcc gatctcggct tgaacgaatt gttaggtggc ggtacttggg     2820

tcgatatcaa agtgcatcac ttcttcccgt atgcccaact ttgtatagag agccactgcg     2880

ggatcgtcac cgtaatctgc ttgcacgtag atcacataag caccaagcgc gttggcctca     2940

tgcttgagga gattgatgag cgcggtggca atgccctgcc tccggtgctc gccggagact     3000

gcgagatcat agatatagat ctcactacgc ggctgctcaa acctgggcag aacgtaagcc     3060

gcgagagcgc caacaaccgc ttcttggtcg aaggcagcaa gcgcgatgaa tgtcttacta     3120

cggagcaagt tcccgaggta atcggagtcc ggctgatgtt gggagtaggt ggctacgtct     3180

ccgaactcac gaccgaaaag atcaagagca gcccgcatgg atttgacttg gtcagggccg     3240

agcctacatg tgcgaatgat gcccatactt gagccaccta actttgtttt agggcgactg     3300

ccctgctgcg taacatcgtt gctgctgcgt aacatcgttg ctgctccata acatcaaaca     3360

tcgacccacg gcgtaacgcg cttgctgctt ggatgcccga ggcatagact gtacaaaaaa     3420

acagtcataa caagccatga aaaccgccac tgcgccgtta ccaccgctgc gttcggtcaa     3480

ggttctggac cagttgcgtg agcgcatacg ctacttgcat tacagtttac gaaccgaaca     3540

ggcttatgtc aactgggttc gtgccttcat ccgtttccac ggtgtgcgtc acccggcaac     3600

cttgggcagc agcgaagtcg aggcatttct gtcctggctg gcgaacgagc gcaaggtttc     3660

ggtctccacg catcgtcagg cattggcggc cttgctgttc ttctacggca aggtgctgtg     3720

cacggatctg ccctggcttc aggagatcgg aagacctcgg ccgtcgcggc gcttgccggt     3780

ggtgctgacc ccggatgaag tggttcgcat cctcggtttt ctggaaggcg agcatcgttt     3840

gttcgcccag gactctagct atagttctag tggttggcta cgtatactcc ggaatattaa     3900

tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt     3960

ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca     4020

ccatcgggcg cggatctcgg tccgttcgaa ccagaactct ggaagcttaa ctcctaaaaa     4080

accgccacca tgaaattctt agtcaacgtt gcccttgttt ttatggtcgt atacatttct     4140

tacatctatg cggccggaca ccaccaccac caccaccacc accaccacca cgacgtcggc     4200

tgggagctgc aacgtcgtcc cctgaactgc atcgtggctg tgtcccagaa catgggtatc     4260

ggcaagaacg gcgacctgcc ctggcctcct ctgcgtaacg agttcaagta cttccagcgt     4320

atgaccacca cctcctccgt cgagggcaag cagaacctgg tcatcatggg tcgcaagacc     4380

tggttctcca tccccgagaa gaaccgtctg ctgaaggacc gtatcaacat cgtgctgtcc     4440

cgcgagctga aggaaccccc tcgtggtgct cacttcctgg ctaagtccct ggacgacgct     4500

ctgcgtctga tcgagcagcc tgagctggct tccaaggtgg acatggtctg gatcgtgggc     4560

ggttcctccg tgtaccaaga ggctatgaac cagcccggtc acttgcgtct gttcgtgacc     4620

cgtatcatgc aagagttcga gtccgacacc ttcttccccg aaatcgacct gggcaagtac     4680

aagctgctgc ccgagtaccc cggtgtcctg tccgaggtgc aagaggaaaa gggtatcaag     4740

tacaagttcg aggtgtacga gaagaaggac ggcgcttccg gtttcgctaa cgagctcggt     4800

cctcgtctga tgggaaaggg cgccggcgag cagaaactca tcagcgaaga agatttgggt     4860

gcggccgctg gctcaggagg tggcagtcag gcgcacgtgc aactgcagca gtctggagga     4920

ggcttggtgc agcctggggg ttccctgcgc ctgtcatgtg cagcctctgg aagcatcttc     4980

agtatttacg ctatgggctg gtacaggcag gctcctggca agcaacgtga actggttgct     5040

gccatctcca gctacggtag taccaactac gctgattcgg tcaagggcag gttcaccatc     5100

tcccgcgaca atgccaagaa taccgtctat ttgcaaatga actctctgaa acctgaggat     5160

acggccgtct actactgcaa cgctgacatt gctactatga ccgcggtagg cggattcgac     5220

tactggggac agggaactca ggtgacggtc tcttccgaac ctaagacccc taaaccccaa     5280

ggggccggcc agggtgctgg tgctggaccg atcaccatca acaacttcaa ttactcggat     5340

ccggtggata acaagaacat cctctacttg gacacacact tgaacacgct ggctaacgag     5400

cctgaaaaag ctttcaggat caccggcaac atttgggtca ttccggatag gttcagcaga     5460

aactctaacc ctaacttgaa caaacctccc agagtgacct cacctaagag tggatactac     5520

gaccccaact acctctcgac tgactccgat aaagacccct tcctgaagga gatcattaaa     5580

ctcttcaagc gcatcaactc tcgtgaaatt ggcgaggaat tgatctaccg cctgagtaca     5640

gacatcccat tcccgggtaa caacaacacc ccaatcaaca ctttcgattt cgatgtcgat     5700

ttcaactcag tggatgtcaa aaccaggcag ggaaacaact gggtgaagac tggtagcatc     5760

aacccatctg tcatcattac tggcccgaga gagaacatca ttgaccctga aacctccact     5820

ttcaagctga caaacaacac gttcgctgct caggaaggct tcggagcgtt gagcatcatt     5880

tctatctcac ctcgcttcat gctgacatac tctaacgcta cgaacgacgt gggagagggc     5940

cgtttcagta agtctgaatt ctgcatggac cctattctga tcctcatgca cgctctcaac     6000

ggcgccatgc acaacttgta cggaattgct atccccaacg accagaccat ttccagcgtg     6060

actagcaaca tcttctactc tcaatacaac gtcaagctgg agtacgcaga aatctacgct     6120

ttcggtggcc caaccattga cttgatcccg aaatcagctc gtaagtattt cgaagaaaaa     6180

gcgctggatt attacaggtc gattgctaag agactcaact ccatcaccac tgctaacccc     6240

tcttcattca acaagtacat tggagaatac aagcagaaac tgatccgcaa gtaccgtttc     6300

gtggtcgaga gttcgggtga agttactgtg aaccgcaaca agttcgtcga gctgtacaac     6360

gaattgacac aaatcttcac ggagttcaac tacgccaaaa tttacaacgt gcaaaaccgt     6420

aagatcgcgc tctctaacgt ctacaccccg gttaccgcta acatcttgga cgataacgtc     6480

tacgacattc agaacggttt caacatccca aagtcgaacc tcaacgtttt gttcatgggt     6540

caaaacttgt cccgcaaccc cgccctgcgt aaggtgaacc cagagaacat gttgtacctg     6600

ttcaccaaat tctgccacaa ggccatcgac ggtcagtctc tagaccaagg aggatgggaa     6660

ctccagcaag gtggccaggg tggaggtgct ggcaccctgg actgtcgcga actgctcgtt     6720

aagaacactg atctcccatt cattggcgac atctctgatg tgaaaacaga cattttcctg     6780

cgtaaggata tcaacgagga aacggaggtc atctactacc ctgacaacgt ctcggttgat     6840

caggttatct tgtcaaagaa caccagtgaa catggccaac tggacttgct gtacccctca     6900

attgattccg agagcgaaat cctgccagga gagaaccagg ttttctacga caacaggaca     6960

caaaacgtgg attacctcaa cagctactac tacctggagt cgcagaagct ctccgacaac     7020

gtcgaagatt tcacatttac gagatcaatc gaggaggctt tggacaacag tgccaaagtc     7080

tacacctact tccctactct ggcaaacaag gtgaacgcgg gtgtccaagg cggactcttc     7140

ttgatgtggg ctaacgacgt tgtggaagat ttcacaacga acatcttgcg caaagacacc     7200

ctggataaga tcagcgatgt ctctgccatc attccataca ttggcccggc actgaacatc     7260

tctaactcag ttcgccgtgg caacttcact gaggcattcg cggtcacagg agttacgatc     7320

ctcttggagg ctttcccgga gttcacaatc cccgcactgg gcgcgttcgt tatctactcc     7380

aaagtgcagg agcgcaacga aatcattaag actatcgaca actgcctgga gcaaaggatc     7440

aaaagatgga aggattcgta cgaatggatg atgggtacct ggctctcccg tatcattacg     7500

cagttcaaca acatcagcta ccaaatgtac gactctctca actaccaggc tggtgccatc     7560

aaggccaaaa ttgacttgga gtacaagaaa tacagtggct cggataaaga gaacatcaag     7620

agtcaagtcg aaaacctgaa aaactcactc gacgttaaga tcagtgaggc aatgaacaac     7680

atcaacaagt tcattcgcga atgttccgtt acctacctct tcaaaaacat gttgccaaag     7740

gtcatcgacg agctgaacga atttgatcgt aacactaagg cgaaactgat taacctcatc     7800

gactcacaca acatcatttt ggtgggcgaa gtcgataagc tgaaagccaa ggtgaacaac     7860

agtttccaga acacaatccc tttcaacatt ttctcataca cgaacaacag tctgctcaag     7920

gacatcatta acgagtactt caacaacatt aacgatagca aaatcctgtc actgcagaac     7980

cgtaagaaca cactggtcga tactagtgga tacaacgccg aagtctctga ggaaggtgac     8040

gtgcagctga accctatctt ccccttcgac ttcaaattgg gctccagcgg agaggatagg     8100

ggcaaggtca tcgtcaccca gaacgagaac atcgtctaca actcaatgta cgaatccttc     8160

agcatctctt tctggatcag gattaacaag tgggtgagca acctgcccgg ttacacaatc     8220

attgactctg tcaagaacaa ctcaggttgg agtatcggca tcatttctaa cttcttggtc     8280

ttcaccctga agcagaacga ggactcggaa caatccatta acttctcata cgatatcagt     8340

aacaacgctc caggttacaa caagtggttc ttcgttaccg tgactaacaa catgatgggt     8400

aacatgaaaa tttacatcaa cggcaagctc attgacacca tcaaagtgaa ggagttgact     8460

ggtattaact tctccaaaac aatcacgttt gaaattaaca agatccctga caccggcctg     8520

atcacttcag acagtgataa catcaacatg tggattaggg atttctacat cttcgccaag     8580

gagctcgacg gaaaggatat taacatcctc ttcaacagct tgcagtacac caacgtcgtt     8640

aaagactact ggggtaacga tttgagatac aacaaggagt actacatggt caacatcgac     8700

tacctgaaca ggtacatgta cgctaactcc cgccaaatcg tgttcaacac caggagaaac     8760

aacaacgact tcaacgaggg ttacaaaatc attatcaagc gcatccgtgg caacaccaac     8820

gatactaggg tgagaggtgg cgacattctg tacttcgata tgactatcaa caacaaagcc     8880

tacaacttgt tcatgaaaaa cgagacaatg tacgccgaca accatagcac ggaggatatt     8940

tacgcaatcg gactgaggga acagacaaag gacatcaacg ataacattat cttccagatc     9000

caacctatga acaacacgta ctactacgct tcgcaaatct tcaagtccaa cttcaacgga     9060

gaaaacattt cgggtatctg ttccattggc acataccgct tccgtctggg tggtgactgg     9120

tatcgtcaca actacctcgt tcccaccgtg aagcagggta actacgcttc tttgctggag     9180

tcgacttcca cgcactgggg attcgttcct gtgtcagagg gcgctggcta cccttacgat     9240

gttcccgact acgctggttg ggaactccag caaggtgcag gatggtccca ccctcaattc     9300

gagaagggtg ccggatggag tcacccacag ttcgagaaag gcgctggatg gagtcaccca     9360

cagttcgaga aataattagt tgatgcatag ttaattagat agctcgaggc atgcggtacc     9420

aagattggat ctagatgcat agttaattag atagctcgag gcatgcggta ccaagcttgt     9480

cgagaagtac tagaggatca taatcagcca taccacattt gtagaggttt tacttgcttt     9540

aaaaaacctc ccacacctcc ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt     9600

taacttgttt attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac     9660

aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc     9720

ttatcatgtc tggatctgat cactgcttga gcctaggaga tccgaaccag ataagtgaaa     9780

tctagttcca aactattttg tcatttttaa ttttcgtatt agcttacgac gctacaccca     9840

gttcccatct attttgtcac tcttccctaa ataatcctta aaaactccat ttccacccct     9900

cccagttccc aactattttg tccgcccaca gcggggcatt tttcttcctg ttatgttttt     9960

aatcaaacat cctgccaact ccatgtgaca aaccgtcatc ttcggctact ttttctctgt    10020

cacagaatga aaatttttct gtcatctctt cgttattaat gtttgtaatt gactgaatat    10080

caacgcttat ttgcagcctg aatggcgaat gg                                  10112


<210>  38
<211>  1761
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein construct

<400>  38

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ala Gly His His His His His His His His His 
            20                  25                  30          


His His Asp Val Gly Trp Glu Leu Gln Arg Arg Pro Leu Asn Cys Ile 
        35                  40                  45              


Val Ala Val Ser Gln Asn Met Gly Ile Gly Lys Asn Gly Asp Leu Pro 
    50                  55                  60                  


Trp Pro Pro Leu Arg Asn Glu Phe Lys Tyr Phe Gln Arg Met Thr Thr 
65                  70                  75                  80  


Thr Ser Ser Val Glu Gly Lys Gln Asn Leu Val Ile Met Gly Arg Lys 
                85                  90                  95      


Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg Leu Leu Lys Asp Arg Ile 
            100                 105                 110         


Asn Ile Val Leu Ser Arg Glu Leu Lys Glu Pro Pro Arg Gly Ala His 
        115                 120                 125             


Phe Leu Ala Lys Ser Leu Asp Asp Ala Leu Arg Leu Ile Glu Gln Pro 
    130                 135                 140                 


Glu Leu Ala Ser Lys Val Asp Met Val Trp Ile Val Gly Gly Ser Ser 
145                 150                 155                 160 


Val Tyr Gln Glu Ala Met Asn Gln Pro Gly His Leu Arg Leu Phe Val 
                165                 170                 175     


Thr Arg Ile Met Gln Glu Phe Glu Ser Asp Thr Phe Phe Pro Glu Ile 
            180                 185                 190         


Asp Leu Gly Lys Tyr Lys Leu Leu Pro Glu Tyr Pro Gly Val Leu Ser 
        195                 200                 205             


Glu Val Gln Glu Glu Lys Gly Ile Lys Tyr Lys Phe Glu Val Tyr Glu 
    210                 215                 220                 


Lys Lys Asp Gly Ala Ser Gly Phe Ala Asn Glu Leu Gly Pro Arg Leu 
225                 230                 235                 240 


Met Gly Lys Gly Ala Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
                245                 250                 255     


Gly Ala Ala Ala Gly Ser Gly Gly Gly Ser Gln Ala His Val Gln Leu 
            260                 265                 270         


Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Tyr Ala Met Gly Trp 
    290                 295                 300                 


Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ala Ile Ser 
305                 310                 315                 320 


Ser Tyr Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
                325                 330                 335     


Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser 
            340                 345                 350         


Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala Asp Ile Ala 
        355                 360                 365             


Thr Met Thr Ala Val Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Gln 
    370                 375                 380                 


Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Gly Ala Gly 
385                 390                 395                 400 


Gln Gly Ala Gly Ala Gly Pro Ile Thr Ile Asn Asn Phe Asn Tyr Ser 
                405                 410                 415     


Asp Pro Val Asp Asn Lys Asn Ile Leu Tyr Leu Asp Thr His Leu Asn 
            420                 425                 430         


Thr Leu Ala Asn Glu Pro Glu Lys Ala Phe Arg Ile Thr Gly Asn Ile 
        435                 440                 445             


Trp Val Ile Pro Asp Arg Phe Ser Arg Asn Ser Asn Pro Asn Leu Asn 
    450                 455                 460                 


Lys Pro Pro Arg Val Thr Ser Pro Lys Ser Gly Tyr Tyr Asp Pro Asn 
465                 470                 475                 480 


Tyr Leu Ser Thr Asp Ser Asp Lys Asp Pro Phe Leu Lys Glu Ile Ile 
                485                 490                 495     


Lys Leu Phe Lys Arg Ile Asn Ser Arg Glu Ile Gly Glu Glu Leu Ile 
            500                 505                 510         


Tyr Arg Leu Ser Thr Asp Ile Pro Phe Pro Gly Asn Asn Asn Thr Pro 
        515                 520                 525             


Ile Asn Thr Phe Asp Phe Asp Val Asp Phe Asn Ser Val Asp Val Lys 
    530                 535                 540                 


Thr Arg Gln Gly Asn Asn Trp Val Lys Thr Gly Ser Ile Asn Pro Ser 
545                 550                 555                 560 


Val Ile Ile Thr Gly Pro Arg Glu Asn Ile Ile Asp Pro Glu Thr Ser 
                565                 570                 575     


Thr Phe Lys Leu Thr Asn Asn Thr Phe Ala Ala Gln Glu Gly Phe Gly 
            580                 585                 590         


Ala Leu Ser Ile Ile Ser Ile Ser Pro Arg Phe Met Leu Thr Tyr Ser 
        595                 600                 605             


Asn Ala Thr Asn Asp Val Gly Glu Gly Arg Phe Ser Lys Ser Glu Phe 
    610                 615                 620                 


Cys Met Asp Pro Ile Leu Ile Leu Met His Ala Leu Asn Gly Ala Met 
625                 630                 635                 640 


His Asn Leu Tyr Gly Ile Ala Ile Pro Asn Asp Gln Thr Ile Ser Ser 
                645                 650                 655     


Val Thr Ser Asn Ile Phe Tyr Ser Gln Tyr Asn Val Lys Leu Glu Tyr 
            660                 665                 670         


Ala Glu Ile Tyr Ala Phe Gly Gly Pro Thr Ile Asp Leu Ile Pro Lys 
        675                 680                 685             


Ser Ala Arg Lys Tyr Phe Glu Glu Lys Ala Leu Asp Tyr Tyr Arg Ser 
    690                 695                 700                 


Ile Ala Lys Arg Leu Asn Ser Ile Thr Thr Ala Asn Pro Ser Ser Phe 
705                 710                 715                 720 


Asn Lys Tyr Ile Gly Glu Tyr Lys Gln Lys Leu Ile Arg Lys Tyr Arg 
                725                 730                 735     


Phe Val Val Glu Ser Ser Gly Glu Val Thr Val Asn Arg Asn Lys Phe 
            740                 745                 750         


Val Glu Leu Tyr Asn Glu Leu Thr Gln Ile Phe Thr Glu Phe Asn Tyr 
        755                 760                 765             


Ala Lys Ile Tyr Asn Val Gln Asn Arg Lys Ile Ala Leu Ser Asn Val 
    770                 775                 780                 


Tyr Thr Pro Val Thr Ala Asn Ile Leu Asp Asp Asn Val Tyr Asp Ile 
785                 790                 795                 800 


Gln Asn Gly Phe Asn Ile Pro Lys Ser Asn Leu Asn Val Leu Phe Met 
                805                 810                 815     


Gly Gln Asn Leu Ser Arg Asn Pro Ala Leu Arg Lys Val Asn Pro Glu 
            820                 825                 830         


Asn Met Leu Tyr Leu Phe Thr Lys Phe Cys His Lys Ala Ile Asp Gly 
        835                 840                 845             


Gln Ser Leu Asp Gln Gly Gly Trp Glu Leu Gln Gln Gly Gly Gln Gly 
    850                 855                 860                 


Gly Gly Ala Gly Thr Leu Asp Cys Arg Glu Leu Leu Val Lys Asn Thr 
865                 870                 875                 880 


Asp Leu Pro Phe Ile Gly Asp Ile Ser Asp Val Lys Thr Asp Ile Phe 
                885                 890                 895     


Leu Arg Lys Asp Ile Asn Glu Glu Thr Glu Val Ile Tyr Tyr Pro Asp 
            900                 905                 910         


Asn Val Ser Val Asp Gln Val Ile Leu Ser Lys Asn Thr Ser Glu His 
        915                 920                 925             


Gly Gln Leu Asp Leu Leu Tyr Pro Ser Ile Asp Ser Glu Ser Glu Ile 
    930                 935                 940                 


Leu Pro Gly Glu Asn Gln Val Phe Tyr Asp Asn Arg Thr Gln Asn Val 
945                 950                 955                 960 


Asp Tyr Leu Asn Ser Tyr Tyr Tyr Leu Glu Ser Gln Lys Leu Ser Asp 
                965                 970                 975     


Asn Val Glu Asp Phe Thr Phe Thr Arg Ser Ile Glu Glu Ala Leu Asp 
            980                 985                 990         


Asn Ser Ala Lys Val Tyr Thr Tyr  Phe Pro Thr Leu Ala  Asn Lys Val 
        995                 1000                 1005             


Asn Ala  Gly Val Gln Gly Gly  Leu Phe Leu Met Trp  Ala Asn Asp 
    1010                 1015                 1020             


Val Val  Glu Asp Phe Thr Thr  Asn Ile Leu Arg Lys  Asp Thr Leu 
    1025                 1030                 1035             


Asp Lys  Ile Ser Asp Val Ser  Ala Ile Ile Pro Tyr  Ile Gly Pro 
    1040                 1045                 1050             


Ala Leu  Asn Ile Ser Asn Ser  Val Arg Arg Gly Asn  Phe Thr Glu 
    1055                 1060                 1065             


Ala Phe  Ala Val Thr Gly Val  Thr Ile Leu Leu Glu  Ala Phe Pro 
    1070                 1075                 1080             


Glu Phe  Thr Ile Pro Ala Leu  Gly Ala Phe Val Ile  Tyr Ser Lys 
    1085                 1090                 1095             


Val Gln  Glu Arg Asn Glu Ile  Ile Lys Thr Ile Asp  Asn Cys Leu 
    1100                 1105                 1110             


Glu Gln  Arg Ile Lys Arg Trp  Lys Asp Ser Tyr Glu  Trp Met Met 
    1115                 1120                 1125             


Gly Thr  Trp Leu Ser Arg Ile  Ile Thr Gln Phe Asn  Asn Ile Ser 
    1130                 1135                 1140             


Tyr Gln  Met Tyr Asp Ser Leu  Asn Tyr Gln Ala Gly  Ala Ile Lys 
    1145                 1150                 1155             


Ala Lys  Ile Asp Leu Glu Tyr  Lys Lys Tyr Ser Gly  Ser Asp Lys 
    1160                 1165                 1170             


Glu Asn  Ile Lys Ser Gln Val  Glu Asn Leu Lys Asn  Ser Leu Asp 
    1175                 1180                 1185             


Val Lys  Ile Ser Glu Ala Met  Asn Asn Ile Asn Lys  Phe Ile Arg 
    1190                 1195                 1200             


Glu Cys  Ser Val Thr Tyr Leu  Phe Lys Asn Met Leu  Pro Lys Val 
    1205                 1210                 1215             


Ile Asp  Glu Leu Asn Glu Phe  Asp Arg Asn Thr Lys  Ala Lys Leu 
    1220                 1225                 1230             


Ile Asn  Leu Ile Asp Ser His  Asn Ile Ile Leu Val  Gly Glu Val 
    1235                 1240                 1245             


Asp Lys  Leu Lys Ala Lys Val  Asn Asn Ser Phe Gln  Asn Thr Ile 
    1250                 1255                 1260             


Pro Phe  Asn Ile Phe Ser Tyr  Thr Asn Asn Ser Leu  Leu Lys Asp 
    1265                 1270                 1275             


Ile Ile  Asn Glu Tyr Phe Asn  Asn Ile Asn Asp Ser  Lys Ile Leu 
    1280                 1285                 1290             


Ser Leu  Gln Asn Arg Lys Asn  Thr Leu Val Asp Thr  Ser Gly Tyr 
    1295                 1300                 1305             


Asn Ala  Glu Val Ser Glu Glu  Gly Asp Val Gln Leu  Asn Pro Ile 
    1310                 1315                 1320             


Phe Pro  Phe Asp Phe Lys Leu  Gly Ser Ser Gly Glu  Asp Arg Gly 
    1325                 1330                 1335             


Lys Val  Ile Val Thr Gln Asn  Glu Asn Ile Val Tyr  Asn Ser Met 
    1340                 1345                 1350             


Tyr Glu  Ser Phe Ser Ile Ser  Phe Trp Ile Arg Ile  Asn Lys Trp 
    1355                 1360                 1365             


Val Ser  Asn Leu Pro Gly Tyr  Thr Ile Ile Asp Ser  Val Lys Asn 
    1370                 1375                 1380             


Asn Ser  Gly Trp Ser Ile Gly  Ile Ile Ser Asn Phe  Leu Val Phe 
    1385                 1390                 1395             


Thr Leu  Lys Gln Asn Glu Asp  Ser Glu Gln Ser Ile  Asn Phe Ser 
    1400                 1405                 1410             


Tyr Asp  Ile Ser Asn Asn Ala  Pro Gly Tyr Asn Lys  Trp Phe Phe 
    1415                 1420                 1425             


Val Thr  Val Thr Asn Asn Met  Met Gly Asn Met Lys  Ile Tyr Ile 
    1430                 1435                 1440             


Asn Gly  Lys Leu Ile Asp Thr  Ile Lys Val Lys Glu  Leu Thr Gly 
    1445                 1450                 1455             


Ile Asn  Phe Ser Lys Thr Ile  Thr Phe Glu Ile Asn  Lys Ile Pro 
    1460                 1465                 1470             


Asp Thr  Gly Leu Ile Thr Ser  Asp Ser Asp Asn Ile  Asn Met Trp 
    1475                 1480                 1485             


Ile Arg  Asp Phe Tyr Ile Phe  Ala Lys Glu Leu Asp  Gly Lys Asp 
    1490                 1495                 1500             


Ile Asn  Ile Leu Phe Asn Ser  Leu Gln Tyr Thr Asn  Val Val Lys 
    1505                 1510                 1515             


Asp Tyr  Trp Gly Asn Asp Leu  Arg Tyr Asn Lys Glu  Tyr Tyr Met 
    1520                 1525                 1530             


Val Asn  Ile Asp Tyr Leu Asn  Arg Tyr Met Tyr Ala  Asn Ser Arg 
    1535                 1540                 1545             


Gln Ile  Val Phe Asn Thr Arg  Arg Asn Asn Asn Asp  Phe Asn Glu 
    1550                 1555                 1560             


Gly Tyr  Lys Ile Ile Ile Lys  Arg Ile Arg Gly Asn  Thr Asn Asp 
    1565                 1570                 1575             


Thr Arg  Val Arg Gly Gly Asp  Ile Leu Tyr Phe Asp  Met Thr Ile 
    1580                 1585                 1590             


Asn Asn  Lys Ala Tyr Asn Leu  Phe Met Lys Asn Glu  Thr Met Tyr 
    1595                 1600                 1605             


Ala Asp  Asn His Ser Thr Glu  Asp Ile Tyr Ala Ile  Gly Leu Arg 
    1610                 1615                 1620             


Glu Gln  Thr Lys Asp Ile Asn  Asp Asn Ile Ile Phe  Gln Ile Gln 
    1625                 1630                 1635             


Pro Met  Asn Asn Thr Tyr Tyr  Tyr Ala Ser Gln Ile  Phe Lys Ser 
    1640                 1645                 1650             


Asn Phe  Asn Gly Glu Asn Ile  Ser Gly Ile Cys Ser  Ile Gly Thr 
    1655                 1660                 1665             


Tyr Arg  Phe Arg Leu Gly Gly  Asp Trp Tyr Arg His  Asn Tyr Leu 
    1670                 1675                 1680             


Val Pro  Thr Val Lys Gln Gly  Asn Tyr Ala Ser Leu  Leu Glu Ser 
    1685                 1690                 1695             


Thr Ser  Thr His Trp Gly Phe  Val Pro Val Ser Glu  Gly Ala Gly 
    1700                 1705                 1710             


Tyr Pro  Tyr Asp Val Pro Asp  Tyr Ala Gly Trp Glu  Leu Gln Gln 
    1715                 1720                 1725             


Gly Ala  Gly Trp Ser His Pro  Gln Phe Glu Lys Gly  Ala Gly Trp 
    1730                 1735                 1740             


Ser His  Pro Gln Phe Glu Lys  Gly Ala Gly Trp Ser  His Pro Gln 
    1745                 1750                 1755             


Phe Glu  Lys 
    1760     


<210>  39
<211>  9890
<212>  DNA
<213>  Artificial

<220>
<223>  DNA construct for molecular construction of fusion proteins

<400>  39
gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc       60

gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc      120

acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt      180

agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg      240

ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt      300

ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta      360

taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt      420

aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt tcggggaaat      480

gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg      540

agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa      600

catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac      660

ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac      720

atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt      780

ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc      840

gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca      900

ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc      960

ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag     1020

gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa     1080

ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg     1140

gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa     1200

ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg     1260

gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt     1320

gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt     1380

caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag     1440

cattggtaac tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat     1500

ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct     1560

taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct     1620

tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca     1680

gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc     1740

agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc     1800

aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct     1860

gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag     1920

gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc     1980

tacaccgaac tgagatacct acagcgtgag cattgagaaa gcgccacgct tcccgaaggg     2040

agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag     2100

cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt     2160

gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac     2220

gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg     2280

ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc     2340

cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcctgatg     2400

cggtattttc tccttacgca tctgtgcggt atttcacacc gcagaccagc cgcgtaacct     2460

ggcaaaatcg gttacggttg agtaataaat ggatgccctg cgtaagcggg tgtgggcgga     2520

caataaagtc ttaaactgaa caaaatagat ctaaactatg acaataaagt cttaaactag     2580

acagaatagt tgtaaactga aatcagtcca gttatgctgt gaaaaagcat actggacttt     2640

tgttatggct aaagcaaact cttcattttc tgaagtgcaa attgcccgtc gtattaaaga     2700

ggggcgtggc caagggcatg gtaaagacta tattcgcggc gttgtgacaa tttaccgaac     2760

aactccgcgg ccgggaagcc gatctcggct tgaacgaatt gttaggtggc ggtacttggg     2820

tcgatatcaa agtgcatcac ttcttcccgt atgcccaact ttgtatagag agccactgcg     2880

ggatcgtcac cgtaatctgc ttgcacgtag atcacataag caccaagcgc gttggcctca     2940

tgcttgagga gattgatgag cgcggtggca atgccctgcc tccggtgctc gccggagact     3000

gcgagatcat agatatagat ctcactacgc ggctgctcaa acctgggcag aacgtaagcc     3060

gcgagagcgc caacaaccgc ttcttggtcg aaggcagcaa gcgcgatgaa tgtcttacta     3120

cggagcaagt tcccgaggta atcggagtcc ggctgatgtt gggagtaggt ggctacgtct     3180

ccgaactcac gaccgaaaag atcaagagca gcccgcatgg atttgacttg gtcagggccg     3240

agcctacatg tgcgaatgat gcccatactt gagccaccta actttgtttt agggcgactg     3300

ccctgctgcg taacatcgtt gctgctgcgt aacatcgttg ctgctccata acatcaaaca     3360

tcgacccacg gcgtaacgcg cttgctgctt ggatgcccga ggcatagact gtacaaaaaa     3420

acagtcataa caagccatga aaaccgccac tgcgccgtta ccaccgctgc gttcggtcaa     3480

ggttctggac cagttgcgtg agcgcatacg ctacttgcat tacagtttac gaaccgaaca     3540

ggcttatgtc aactgggttc gtgccttcat ccgtttccac ggtgtgcgtc acccggcaac     3600

cttgggcagc agcgaagtcg aggcatttct gtcctggctg gcgaacgagc gcaaggtttc     3660

ggtctccacg catcgtcagg cattggcggc cttgctgttc ttctacggca aggtgctgtg     3720

cacggatctg ccctggcttc aggagatcgg aagacctcgg ccgtcgcggc gcttgccggt     3780

ggtgctgacc ccggatgaag tggttcgcat cctcggtttt ctggaaggcg agcatcgttt     3840

gttcgcccag gactctagct atagttctag tggttggcta cgtatactcc ggaatattaa     3900

tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt     3960

ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca     4020

ccatcgggcg cggatctcgg tccgttcgaa ccagaactct ggaagcttaa ctcctaaaaa     4080

accgccacca tgaaattctt agtcaacgtt gcccttgttt ttatggtcgt atacatttct     4140

tacatctatg cggccggaca ccaccaccac caccaccacc accaccacca cgacgtcggc     4200

tgggagctgc aaggcgccgg cgagcagaaa ctcatcagcg aagaagattt gggtgcggcc     4260

gctcaggttc aactcgtgga gagtggtggc ggactggtgc aatccggtgg cagcctgagg     4320

ctctcctgcg ctgcctctgg atcaatcgac agcctgtacc acatgggttg gtacaggcag     4380

gctcccggca aggagaggga actcgtcgcc agagttcaag acggaggtag tacagcatac     4440

aaggattcgg tcaaaggtcg cttcaccatt tctcgcgact tcagtcgttc gactatgtac     4500

ttgcagatga actcactgaa gcctgaggat acagccatct actactgtgc agcgaaatct     4560

accatttcaa ctccactgtc ttggggccag ggaacacaag tgacggtctc cagcgaaccg     4620

aagacgccta aaccccaatc ttcaggcgga ggtgcggccg ctggctcagg aggtggcagt     4680

caggtgcagc tggtggaatc cggtggtgga ctggtccagc ctggtggttc cctgcgtctg     4740

tcctgcgctg cttccggttt ccccttccac gcttactaca tgtcctgggt ccgccaggct     4800

cctggcaagg gattggaatg ggtgtcccac atcggcaacg gtggtatcat cacccgttac     4860

gctgactccg tgaagggccg tttcaccatc tcccgtgaca acgctaagaa caccctgtac     4920

ctgcagatga ccaacctgaa gcccgaggac accgctctgt actactgcac cctgggcacc     4980

cgtgacgacc tgggtcctga acgtggccag ggaacccaag tgaccgtgtc ctccgagccc     5040

aagaccccca agcctcaagg ggccggccag ggtgctggtg ctggaccgat caccatcaac     5100

aacttcaatt actcggatcc ggtggataac aagaacatcc tctacttgga cacacacttg     5160

aacacgctgg ctaacgagcc tgaaaaagct ttcaggatca ccggcaacat ttgggtcatt     5220

ccggataggt tcagcagaaa ctctaaccct aacttgaaca aacctcccag agtgacctca     5280

cctaagagtg gatactacga ccccaactac ctctcgactg actccgataa agaccccttc     5340

ctgaaggaga tcattaaact cttcaagcgc atcaactctc gtgaaattgg cgaggaattg     5400

atctaccgcc tgagtacaga catcccattc ccgggtaaca acaacacccc aatcaacact     5460

ttcgatttcg atgtcgattt caactcagtg gatgtcaaaa ccaggcaggg aaacaactgg     5520

gtgaagactg gtagcatcaa cccatctgtc atcattactg gcccgagaga gaacatcatt     5580

gaccctgaaa cctccacttt caagctgaca aacaacacgt tcgctgctca ggaaggcttc     5640

ggagcgttga gcatcatttc tatctcacct cgcttcatgc tgacatactc taacgctacg     5700

aacgacgtgg gagagggccg tttcagtaag tctgaattct gcatggaccc tattctgatc     5760

ctcatgcacg ctctcaacgg cgccatgcac aacttgtacg gaattgctat ccccaacgac     5820

cagaccattt ccagcgtgac tagcaacatc ttctactctc aatacaacgt caagctggag     5880

tacgcagaaa tctacgcttt cggtggccca accattgact tgatcccgaa atcagctcgt     5940

aagtatttcg aagaaaaagc gctggattat tacaggtcga ttgctaagag actcaactcc     6000

atcaccactg ctaacccctc ttcattcaac aagtacattg gagaatacaa gcagaaactg     6060

atccgcaagt accgtttcgt ggtcgagagt tcgggtgaag ttactgtgaa ccgcaacaag     6120

ttcgtcgagc tgtacaacga attgacacaa atcttcacgg agttcaacta cgccaaaatt     6180

tacaacgtgc aaaaccgtaa gatcgcgctc tctaacgtct acaccccggt taccgctaac     6240

atcttggacg ataacgtcta cgacattcag aacggtttca acatcccaaa gtcgaacctc     6300

aacgttttgt tcatgggtca aaacttgtcc cgcaaccccg ccctgcgtaa ggtgaaccca     6360

gagaacatgt tgtacctgtt caccaaattc tgccacaagg ccatcgacgg tcagtctcta     6420

gaccaaggag gatgggaact ccagcaaggt ggccagggtg gaggtgctgg caccctggac     6480

tgtcgcgaac tgctcgttaa gaacactgat ctcccattca ttggcgacat ctctgatgtg     6540

aaaacagaca ttttcctgcg taaggatatc aacgaggaaa cggaggtcat ctactaccct     6600

gacaacgtct cggttgatca ggttatcttg tcaaagaaca ccagtgaaca tggccaactg     6660

gacttgctgt acccctcaat tgattccgag agcgaaatcc tgccaggaga gaaccaggtt     6720

ttctacgaca acaggacaca aaacgtggat tacctcaaca gctactacta cctggagtcg     6780

cagaagctct ccgacaacgt cgaagatttc acatttacga gatcaatcga ggaggctttg     6840

gacaacagtg ccaaagtcta cacctacttc cctactctgg caaacaaggt gaacgcgggt     6900

gtccaaggcg gactcttctt gatgtgggct aacgacgttg tggaagattt cacaacgaac     6960

atcttgcgca aagacaccct ggataagatc agcgatgtct ctgccatcat tccatacatt     7020

ggcccggcac tgaacatctc taactcagtt cgccgtggca acttcactga ggcattcgcg     7080

gtcacaggag ttacgatcct cttggaggct ttcccggagt tcacaatccc cgcactgggc     7140

gcgttcgtta tctactccaa agtgcaggag cgcaacgaaa tcattaagac tatcgacaac     7200

tgcctggagc aaaggatcaa aagatggaag gattcgtacg aatggatgat gggtacctgg     7260

ctctcccgta tcattacgca gttcaacaac atcagctacc aaatgtacga ctctctcaac     7320

taccaggctg gtgccatcaa ggccaaaatt gacttggagt acaagaaata cagtggctcg     7380

gataaagaga acatcaagag tcaagtcgaa aacctgaaaa actcactcga cgttaagatc     7440

agtgaggcaa tgaacaacat caacaagttc attcgcgaat gttccgttac ctacctcttc     7500

aaaaacatgt tgccaaaggt catcgacgag ctgaacgaat ttgatcgtaa cactaaggcg     7560

aaactgatta acctcatcga ctcacacaac atcattttgg tgggcgaagt cgataagctg     7620

aaagccaagg tgaacaacag tttccagaac acaatccctt tcaacatttt ctcatacacg     7680

aacaacagtc tgctcaagga catcattaac gagtacttca acaacattaa cgatagcaaa     7740

atcctgtcac tgcagaaccg taagaacaca ctggtcgata ctagtggata caacgccgaa     7800

gtctctgagg aaggtgacgt gcagctgaac cctatcttcc ccttcgactt caaattgggc     7860

tccagcggag aggatagggg caaggtcatc gtcacccaga acgagaacat cgtctacaac     7920

tcaatgtacg aatccttcag catctctttc tggatcagga ttaacaagtg ggtgagcaac     7980

ctgcccggtt acacaatcat tgactctgtc aagaacaact caggttggag tatcggcatc     8040

atttctaact tcttggtctt caccctgaag cagaacgagg actcggaaca atccattaac     8100

ttctcatacg atatcagtaa caacgctcca ggttacaaca agtggttctt cgttaccgtg     8160

actaacaaca tgatgggtaa catgaaaatt tacatcaacg gcaagctcat tgacaccatc     8220

aaagtgaagg agttgactgg tattaacttc tccaaaacaa tcacgtttga aattaacaag     8280

atccctgaca ccggcctgat cacttcagac agtgataaca tcaacatgtg gattagggat     8340

ttctacatct tcgccaagga gctcgacgga aaggatatta acatcctctt caacagcttg     8400

cagtacacca acgtcgttaa agactactgg ggtaacgatt tgagatacaa caaggagtac     8460

tacatggtca acatcgacta cctgaacagg tacatgtacg ctaactcccg ccaaatcgtg     8520

ttcaacacca ggagaaacaa caacgacttc aacgagggtt acaaaatcat tatcaagcgc     8580

atccgtggca acaccaacga tactagggtg agaggtggcg acattctgta cttcgatatg     8640

actatcaaca acaaagccta caacttgttc atgaaaaacg agacaatgta cgccgacaac     8700

catagcacgg aggatattta cgcaatcgga ctgagggaac agacaaagga catcaacgat     8760

aacattatct tccagatcca acctatgaac aacacgtact actacgcttc gcaaatcttc     8820

aagtccaact tcaacggaga aaacatttcg ggtatctgtt ccattggcac ataccgcttc     8880

cgtctgggtg gtgactggta tcgtcacaac tacctcgttc ccaccgtgaa gcagggtaac     8940

tacgcttctt tgctggagtc gacttccacg cactggggat tcgttcctgt gtcagagggc     9000

gctggctacc cttacgatgt tcccgactac gctggttggg aactccagca aggtgcagga     9060

tggtcccacc ctcaattcga gaagggtgcc ggatggagtc acccacagtt cgagaaaggc     9120

gctggatgga gtcacccaca gttcgagaaa taattagttg atgcatagtt aattagatag     9180

ctcgaggcat gcggtaccaa gattggatct agatgcatag ttaattagat agctcgaggc     9240

atgcggtacc aagcttgtcg agaagtacta gaggatcata atcagccata ccacatttgt     9300

agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat     9360

gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa     9420

tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc     9480

caaactcatc aatgtatctt atcatgtctg gatctgatca ctgcttgagc ctaggagatc     9540

cgaaccagat aagtgaaatc tagttccaaa ctattttgtc atttttaatt ttcgtattag     9600

cttacgacgc tacacccagt tcccatctat tttgtcactc ttccctaaat aatccttaaa     9660

aactccattt ccacccctcc cagttcccaa ctattttgtc cgcccacagc ggggcatttt     9720

tcttcctgtt atgtttttaa tcaaacatcc tgccaactcc atgtgacaaa ccgtcatctt     9780

cggctacttt ttctctgtca cagaatgaaa atttttctgt catctcttcg ttattaatgt     9840

ttgtaattga ctgaatatca acgcttattt gcagcctgaa tggcgaatgg                9890


<210>  40
<211>  1687
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein construct

<400>  40

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ala Gly His His His His His His His His His 
            20                  25                  30          


His His Asp Val Gly Trp Glu Leu Gln Gly Ala Gly Glu Gln Lys Leu 
        35                  40                  45              


Ile Ser Glu Glu Asp Leu Gly Ala Ala Ala Gln Val Gln Leu Val Glu 
    50                  55                  60                  


Ser Gly Gly Gly Leu Val Gln Ser Gly Gly Ser Leu Arg Leu Ser Cys 
65                  70                  75                  80  


Ala Ala Ser Gly Ser Ile Asp Ser Leu Tyr His Met Gly Trp Tyr Arg 
                85                  90                  95      


Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Arg Val Gln Asp Gly 
            100                 105                 110         


Gly Ser Thr Ala Tyr Lys Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        115                 120                 125             


Arg Asp Phe Ser Arg Ser Thr Met Tyr Leu Gln Met Asn Ser Leu Lys 
    130                 135                 140                 


Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Lys Ser Thr Ile Ser 
145                 150                 155                 160 


Thr Pro Leu Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu 
                165                 170                 175     


Pro Lys Thr Pro Lys Pro Gln Ser Ser Gly Gly Gly Ala Ala Ala Gly 
            180                 185                 190         


Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
        195                 200                 205             


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    210                 215                 220                 


Pro Phe His Ala Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
225                 230                 235                 240 


Gly Leu Glu Trp Val Ser His Ile Gly Asn Gly Gly Ile Ile Thr Arg 
                245                 250                 255     


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
            260                 265                 270         


Lys Asn Thr Leu Tyr Leu Gln Met Thr Asn Leu Lys Pro Glu Asp Thr 
        275                 280                 285             


Ala Leu Tyr Tyr Cys Thr Leu Gly Thr Arg Asp Asp Leu Gly Pro Glu 
    290                 295                 300                 


Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro 
305                 310                 315                 320 


Lys Pro Gln Gly Ala Gly Gln Gly Ala Gly Ala Gly Pro Ile Thr Ile 
                325                 330                 335     


Asn Asn Phe Asn Tyr Ser Asp Pro Val Asp Asn Lys Asn Ile Leu Tyr 
            340                 345                 350         


Leu Asp Thr His Leu Asn Thr Leu Ala Asn Glu Pro Glu Lys Ala Phe 
        355                 360                 365             


Arg Ile Thr Gly Asn Ile Trp Val Ile Pro Asp Arg Phe Ser Arg Asn 
    370                 375                 380                 


Ser Asn Pro Asn Leu Asn Lys Pro Pro Arg Val Thr Ser Pro Lys Ser 
385                 390                 395                 400 


Gly Tyr Tyr Asp Pro Asn Tyr Leu Ser Thr Asp Ser Asp Lys Asp Pro 
                405                 410                 415     


Phe Leu Lys Glu Ile Ile Lys Leu Phe Lys Arg Ile Asn Ser Arg Glu 
            420                 425                 430         


Ile Gly Glu Glu Leu Ile Tyr Arg Leu Ser Thr Asp Ile Pro Phe Pro 
        435                 440                 445             


Gly Asn Asn Asn Thr Pro Ile Asn Thr Phe Asp Phe Asp Val Asp Phe 
    450                 455                 460                 


Asn Ser Val Asp Val Lys Thr Arg Gln Gly Asn Asn Trp Val Lys Thr 
465                 470                 475                 480 


Gly Ser Ile Asn Pro Ser Val Ile Ile Thr Gly Pro Arg Glu Asn Ile 
                485                 490                 495     


Ile Asp Pro Glu Thr Ser Thr Phe Lys Leu Thr Asn Asn Thr Phe Ala 
            500                 505                 510         


Ala Gln Glu Gly Phe Gly Ala Leu Ser Ile Ile Ser Ile Ser Pro Arg 
        515                 520                 525             


Phe Met Leu Thr Tyr Ser Asn Ala Thr Asn Asp Val Gly Glu Gly Arg 
    530                 535                 540                 


Phe Ser Lys Ser Glu Phe Cys Met Asp Pro Ile Leu Ile Leu Met His 
545                 550                 555                 560 


Ala Leu Asn Gly Ala Met His Asn Leu Tyr Gly Ile Ala Ile Pro Asn 
                565                 570                 575     


Asp Gln Thr Ile Ser Ser Val Thr Ser Asn Ile Phe Tyr Ser Gln Tyr 
            580                 585                 590         


Asn Val Lys Leu Glu Tyr Ala Glu Ile Tyr Ala Phe Gly Gly Pro Thr 
        595                 600                 605             


Ile Asp Leu Ile Pro Lys Ser Ala Arg Lys Tyr Phe Glu Glu Lys Ala 
    610                 615                 620                 


Leu Asp Tyr Tyr Arg Ser Ile Ala Lys Arg Leu Asn Ser Ile Thr Thr 
625                 630                 635                 640 


Ala Asn Pro Ser Ser Phe Asn Lys Tyr Ile Gly Glu Tyr Lys Gln Lys 
                645                 650                 655     


Leu Ile Arg Lys Tyr Arg Phe Val Val Glu Ser Ser Gly Glu Val Thr 
            660                 665                 670         


Val Asn Arg Asn Lys Phe Val Glu Leu Tyr Asn Glu Leu Thr Gln Ile 
        675                 680                 685             


Phe Thr Glu Phe Asn Tyr Ala Lys Ile Tyr Asn Val Gln Asn Arg Lys 
    690                 695                 700                 


Ile Ala Leu Ser Asn Val Tyr Thr Pro Val Thr Ala Asn Ile Leu Asp 
705                 710                 715                 720 


Asp Asn Val Tyr Asp Ile Gln Asn Gly Phe Asn Ile Pro Lys Ser Asn 
                725                 730                 735     


Leu Asn Val Leu Phe Met Gly Gln Asn Leu Ser Arg Asn Pro Ala Leu 
            740                 745                 750         


Arg Lys Val Asn Pro Glu Asn Met Leu Tyr Leu Phe Thr Lys Phe Cys 
        755                 760                 765             


His Lys Ala Ile Asp Gly Gln Ser Leu Asp Gln Gly Gly Trp Glu Leu 
    770                 775                 780                 


Gln Gln Gly Gly Gln Gly Gly Gly Ala Gly Thr Leu Asp Cys Arg Glu 
785                 790                 795                 800 


Leu Leu Val Lys Asn Thr Asp Leu Pro Phe Ile Gly Asp Ile Ser Asp 
                805                 810                 815     


Val Lys Thr Asp Ile Phe Leu Arg Lys Asp Ile Asn Glu Glu Thr Glu 
            820                 825                 830         


Val Ile Tyr Tyr Pro Asp Asn Val Ser Val Asp Gln Val Ile Leu Ser 
        835                 840                 845             


Lys Asn Thr Ser Glu His Gly Gln Leu Asp Leu Leu Tyr Pro Ser Ile 
    850                 855                 860                 


Asp Ser Glu Ser Glu Ile Leu Pro Gly Glu Asn Gln Val Phe Tyr Asp 
865                 870                 875                 880 


Asn Arg Thr Gln Asn Val Asp Tyr Leu Asn Ser Tyr Tyr Tyr Leu Glu 
                885                 890                 895     


Ser Gln Lys Leu Ser Asp Asn Val Glu Asp Phe Thr Phe Thr Arg Ser 
            900                 905                 910         


Ile Glu Glu Ala Leu Asp Asn Ser Ala Lys Val Tyr Thr Tyr Phe Pro 
        915                 920                 925             


Thr Leu Ala Asn Lys Val Asn Ala Gly Val Gln Gly Gly Leu Phe Leu 
    930                 935                 940                 


Met Trp Ala Asn Asp Val Val Glu Asp Phe Thr Thr Asn Ile Leu Arg 
945                 950                 955                 960 


Lys Asp Thr Leu Asp Lys Ile Ser Asp Val Ser Ala Ile Ile Pro Tyr 
                965                 970                 975     


Ile Gly Pro Ala Leu Asn Ile Ser Asn Ser Val Arg Arg Gly Asn Phe 
            980                 985                 990         


Thr Glu Ala Phe Ala Val Thr Gly  Val Thr Ile Leu Leu  Glu Ala Phe 
        995                 1000                 1005             


Pro Glu  Phe Thr Ile Pro Ala  Leu Gly Ala Phe Val  Ile Tyr Ser 
    1010                 1015                 1020             


Lys Val  Gln Glu Arg Asn Glu  Ile Ile Lys Thr Ile  Asp Asn Cys 
    1025                 1030                 1035             


Leu Glu  Gln Arg Ile Lys Arg  Trp Lys Asp Ser Tyr  Glu Trp Met 
    1040                 1045                 1050             


Met Gly  Thr Trp Leu Ser Arg  Ile Ile Thr Gln Phe  Asn Asn Ile 
    1055                 1060                 1065             


Ser Tyr  Gln Met Tyr Asp Ser  Leu Asn Tyr Gln Ala  Gly Ala Ile 
    1070                 1075                 1080             


Lys Ala  Lys Ile Asp Leu Glu  Tyr Lys Lys Tyr Ser  Gly Ser Asp 
    1085                 1090                 1095             


Lys Glu  Asn Ile Lys Ser Gln  Val Glu Asn Leu Lys  Asn Ser Leu 
    1100                 1105                 1110             


Asp Val  Lys Ile Ser Glu Ala  Met Asn Asn Ile Asn  Lys Phe Ile 
    1115                 1120                 1125             


Arg Glu  Cys Ser Val Thr Tyr  Leu Phe Lys Asn Met  Leu Pro Lys 
    1130                 1135                 1140             


Val Ile  Asp Glu Leu Asn Glu  Phe Asp Arg Asn Thr  Lys Ala Lys 
    1145                 1150                 1155             


Leu Ile  Asn Leu Ile Asp Ser  His Asn Ile Ile Leu  Val Gly Glu 
    1160                 1165                 1170             


Val Asp  Lys Leu Lys Ala Lys  Val Asn Asn Ser Phe  Gln Asn Thr 
    1175                 1180                 1185             


Ile Pro  Phe Asn Ile Phe Ser  Tyr Thr Asn Asn Ser  Leu Leu Lys 
    1190                 1195                 1200             


Asp Ile  Ile Asn Glu Tyr Phe  Asn Asn Ile Asn Asp  Ser Lys Ile 
    1205                 1210                 1215             


Leu Ser  Leu Gln Asn Arg Lys  Asn Thr Leu Val Asp  Thr Ser Gly 
    1220                 1225                 1230             


Tyr Asn  Ala Glu Val Ser Glu  Glu Gly Asp Val Gln  Leu Asn Pro 
    1235                 1240                 1245             


Ile Phe  Pro Phe Asp Phe Lys  Leu Gly Ser Ser Gly  Glu Asp Arg 
    1250                 1255                 1260             


Gly Lys  Val Ile Val Thr Gln  Asn Glu Asn Ile Val  Tyr Asn Ser 
    1265                 1270                 1275             


Met Tyr  Glu Ser Phe Ser Ile  Ser Phe Trp Ile Arg  Ile Asn Lys 
    1280                 1285                 1290             


Trp Val  Ser Asn Leu Pro Gly  Tyr Thr Ile Ile Asp  Ser Val Lys 
    1295                 1300                 1305             


Asn Asn  Ser Gly Trp Ser Ile  Gly Ile Ile Ser Asn  Phe Leu Val 
    1310                 1315                 1320             


Phe Thr  Leu Lys Gln Asn Glu  Asp Ser Glu Gln Ser  Ile Asn Phe 
    1325                 1330                 1335             


Ser Tyr  Asp Ile Ser Asn Asn  Ala Pro Gly Tyr Asn  Lys Trp Phe 
    1340                 1345                 1350             


Phe Val  Thr Val Thr Asn Asn  Met Met Gly Asn Met  Lys Ile Tyr 
    1355                 1360                 1365             


Ile Asn  Gly Lys Leu Ile Asp  Thr Ile Lys Val Lys  Glu Leu Thr 
    1370                 1375                 1380             


Gly Ile  Asn Phe Ser Lys Thr  Ile Thr Phe Glu Ile  Asn Lys Ile 
    1385                 1390                 1395             


Pro Asp  Thr Gly Leu Ile Thr  Ser Asp Ser Asp Asn  Ile Asn Met 
    1400                 1405                 1410             


Trp Ile  Arg Asp Phe Tyr Ile  Phe Ala Lys Glu Leu  Asp Gly Lys 
    1415                 1420                 1425             


Asp Ile  Asn Ile Leu Phe Asn  Ser Leu Gln Tyr Thr  Asn Val Val 
    1430                 1435                 1440             


Lys Asp  Tyr Trp Gly Asn Asp  Leu Arg Tyr Asn Lys  Glu Tyr Tyr 
    1445                 1450                 1455             


Met Val  Asn Ile Asp Tyr Leu  Asn Arg Tyr Met Tyr  Ala Asn Ser 
    1460                 1465                 1470             


Arg Gln  Ile Val Phe Asn Thr  Arg Arg Asn Asn Asn  Asp Phe Asn 
    1475                 1480                 1485             


Glu Gly  Tyr Lys Ile Ile Ile  Lys Arg Ile Arg Gly  Asn Thr Asn 
    1490                 1495                 1500             


Asp Thr  Arg Val Arg Gly Gly  Asp Ile Leu Tyr Phe  Asp Met Thr 
    1505                 1510                 1515             


Ile Asn  Asn Lys Ala Tyr Asn  Leu Phe Met Lys Asn  Glu Thr Met 
    1520                 1525                 1530             


Tyr Ala  Asp Asn His Ser Thr  Glu Asp Ile Tyr Ala  Ile Gly Leu 
    1535                 1540                 1545             


Arg Glu  Gln Thr Lys Asp Ile  Asn Asp Asn Ile Ile  Phe Gln Ile 
    1550                 1555                 1560             


Gln Pro  Met Asn Asn Thr Tyr  Tyr Tyr Ala Ser Gln  Ile Phe Lys 
    1565                 1570                 1575             


Ser Asn  Phe Asn Gly Glu Asn  Ile Ser Gly Ile Cys  Ser Ile Gly 
    1580                 1585                 1590             


Thr Tyr  Arg Phe Arg Leu Gly  Gly Asp Trp Tyr Arg  His Asn Tyr 
    1595                 1600                 1605             


Leu Val  Pro Thr Val Lys Gln  Gly Asn Tyr Ala Ser  Leu Leu Glu 
    1610                 1615                 1620             


Ser Thr  Ser Thr His Trp Gly  Phe Val Pro Val Ser  Glu Gly Ala 
    1625                 1630                 1635             


Gly Tyr  Pro Tyr Asp Val Pro  Asp Tyr Ala Gly Trp  Glu Leu Gln 
    1640                 1645                 1650             


Gln Gly  Ala Gly Trp Ser His  Pro Gln Phe Glu Lys  Gly Ala Gly 
    1655                 1660                 1665             


Trp Ser  His Pro Gln Phe Glu  Lys Gly Ala Gly Trp  Ser His Pro 
    1670                 1675                 1680             


Gln Phe  Glu Lys 
    1685         


<210>  41
<211>  10496
<212>  DNA
<213>  Artificial

<220>
<223>  DNA construct for molecular construction of fusion proteins

<400>  41
gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc       60

gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc      120

acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt      180

agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg      240

ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt      300

ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta      360

taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt      420

aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt tcggggaaat      480

gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg      540

agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa      600

catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac      660

ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac      720

atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt      780

ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc      840

gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca      900

ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc      960

ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag     1020

gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa     1080

ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg     1140

gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa     1200

ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg     1260

gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt     1320

gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt     1380

caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag     1440

cattggtaac tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat     1500

ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct     1560

taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct     1620

tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca     1680

gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc     1740

agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc     1800

aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct     1860

gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag     1920

gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc     1980

tacaccgaac tgagatacct acagcgtgag cattgagaaa gcgccacgct tcccgaaggg     2040

agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag     2100

cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt     2160

gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac     2220

gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg     2280

ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc     2340

cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcctgatg     2400

cggtattttc tccttacgca tctgtgcggt atttcacacc gcagaccagc cgcgtaacct     2460

ggcaaaatcg gttacggttg agtaataaat ggatgccctg cgtaagcggg tgtgggcgga     2520

caataaagtc ttaaactgaa caaaatagat ctaaactatg acaataaagt cttaaactag     2580

acagaatagt tgtaaactga aatcagtcca gttatgctgt gaaaaagcat actggacttt     2640

tgttatggct aaagcaaact cttcattttc tgaagtgcaa attgcccgtc gtattaaaga     2700

ggggcgtggc caagggcatg gtaaagacta tattcgcggc gttgtgacaa tttaccgaac     2760

aactccgcgg ccgggaagcc gatctcggct tgaacgaatt gttaggtggc ggtacttggg     2820

tcgatatcaa agtgcatcac ttcttcccgt atgcccaact ttgtatagag agccactgcg     2880

ggatcgtcac cgtaatctgc ttgcacgtag atcacataag caccaagcgc gttggcctca     2940

tgcttgagga gattgatgag cgcggtggca atgccctgcc tccggtgctc gccggagact     3000

gcgagatcat agatatagat ctcactacgc ggctgctcaa acctgggcag aacgtaagcc     3060

gcgagagcgc caacaaccgc ttcttggtcg aaggcagcaa gcgcgatgaa tgtcttacta     3120

cggagcaagt tcccgaggta atcggagtcc ggctgatgtt gggagtaggt ggctacgtct     3180

ccgaactcac gaccgaaaag atcaagagca gcccgcatgg atttgacttg gtcagggccg     3240

agcctacatg tgcgaatgat gcccatactt gagccaccta actttgtttt agggcgactg     3300

ccctgctgcg taacatcgtt gctgctgcgt aacatcgttg ctgctccata acatcaaaca     3360

tcgacccacg gcgtaacgcg cttgctgctt ggatgcccga ggcatagact gtacaaaaaa     3420

acagtcataa caagccatga aaaccgccac tgcgccgtta ccaccgctgc gttcggtcaa     3480

ggttctggac cagttgcgtg agcgcatacg ctacttgcat tacagtttac gaaccgaaca     3540

ggcttatgtc aactgggttc gtgccttcat ccgtttccac ggtgtgcgtc acccggcaac     3600

cttgggcagc agcgaagtcg aggcatttct gtcctggctg gcgaacgagc gcaaggtttc     3660

ggtctccacg catcgtcagg cattggcggc cttgctgttc ttctacggca aggtgctgtg     3720

cacggatctg ccctggcttc aggagatcgg aagacctcgg ccgtcgcggc gcttgccggt     3780

ggtgctgacc ccggatgaag tggttcgcat cctcggtttt ctggaaggcg agcatcgttt     3840

gttcgcccag gactctagct atagttctag tggttggcta cgtatactcc ggaatattaa     3900

tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt     3960

ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca     4020

ccatcgggcg cggatctcgg tccgttcgaa ccagaactct ggaagcttaa ctcctaaaaa     4080

accgccacca tgaaattctt agtcaacgtt gcccttgttt ttatggtcgt atacatttct     4140

tacatctatg cggccggaca ccaccaccac caccaccacc accaccacca cgacgtcggc     4200

tgggagctgc aacgtcgtcc cctgaactgc atcgtggctg tgtcccagaa catgggtatc     4260

ggcaagaacg gcgacctgcc ctggcctcct ctgcgtaacg agttcaagta cttccagcgt     4320

atgaccacca cctcctccgt cgagggcaag cagaacctgg tcatcatggg tcgcaagacc     4380

tggttctcca tccccgagaa gaaccgtctg ctgaaggacc gtatcaacat cgtgctgtcc     4440

cgcgagctga aggaaccccc tcgtggtgct cacttcctgg ctaagtccct ggacgacgct     4500

ctgcgtctga tcgagcagcc tgagctggct tccaaggtgg acatggtctg gatcgtgggc     4560

ggttcctccg tgtaccaaga ggctatgaac cagcccggtc acttgcgtct gttcgtgacc     4620

cgtatcatgc aagagttcga gtccgacacc ttcttccccg aaatcgacct gggcaagtac     4680

aagctgctgc ccgagtaccc cggtgtcctg tccgaggtgc aagaggaaaa gggtatcaag     4740

tacaagttcg aggtgtacga gaagaaggac ggcgcttccg gtttcgctaa cgagctcggt     4800

cctcgtctga tgggaaaggg cgccggcgag cagaaactca tcagcgaaga agatttgggt     4860

gcggccgctc aggttcaact cgtggagagt ggtggcggac tggtgcaatc cggtggcagc     4920

ctgaggctct cctgcgctgc ctctggatca atcgacagcc tgtaccacat gggttggtac     4980

aggcaggctc ccggcaagga gagggaactc gtcgccagag ttcaagacgg aggtagtaca     5040

gcatacaagg attcggtcaa aggtcgcttc accatttctc gcgacttcag tcgttcgact     5100

atgtacttgc agatgaactc actgaagcct gaggatacag ccatctacta ctgtgcagcg     5160

aaatctacca tttcaactcc actgtcttgg ggccagggaa cacaagtgac ggtctccagc     5220

gaaccgaaga cgcctaaacc ccaatcttca ggcggaggtg cggccgctgg ctcaggaggt     5280

ggcagtcagg tgcagctggt ggaatccggt ggtggactgg tccagcctgg tggttccctg     5340

cgtctgtcct gcgctgcttc cggtttcccc ttccacgctt actacatgtc ctgggtccgc     5400

caggctcctg gcaagggatt ggaatgggtg tcccacatcg gcaacggtgg tatcatcacc     5460

cgttacgctg actccgtgaa gggccgtttc accatctccc gtgacaacgc taagaacacc     5520

ctgtacctgc agatgaccaa cctgaagccc gaggacaccg ctctgtacta ctgcaccctg     5580

ggcacccgtg acgacctggg tcctgaacgt ggccagggaa cccaagtgac cgtgtcctcc     5640

gagcccaaga cccccaagcc tcaaggggcc ggccagggtg ctggtgctgg accgatcacc     5700

atcaacaact tcaattactc ggatccggtg gataacaaga acatcctcta cttggacaca     5760

cacttgaaca cgctggctaa cgagcctgaa aaagctttca ggatcaccgg caacatttgg     5820

gtcattccgg ataggttcag cagaaactct aaccctaact tgaacaaacc tcccagagtg     5880

acctcaccta agagtggata ctacgacccc aactacctct cgactgactc cgataaagac     5940

cccttcctga aggagatcat taaactcttc aagcgcatca actctcgtga aattggcgag     6000

gaattgatct accgcctgag tacagacatc ccattcccgg gtaacaacaa caccccaatc     6060

aacactttcg atttcgatgt cgatttcaac tcagtggatg tcaaaaccag gcagggaaac     6120

aactgggtga agactggtag catcaaccca tctgtcatca ttactggccc gagagagaac     6180

atcattgacc ctgaaacctc cactttcaag ctgacaaaca acacgttcgc tgctcaggaa     6240

ggcttcggag cgttgagcat catttctatc tcacctcgct tcatgctgac atactctaac     6300

gctacgaacg acgtgggaga gggccgtttc agtaagtctg aattctgcat ggaccctatt     6360

ctgatcctca tgcacgctct caacggcgcc atgcacaact tgtacggaat tgctatcccc     6420

aacgaccaga ccatttccag cgtgactagc aacatcttct actctcaata caacgtcaag     6480

ctggagtacg cagaaatcta cgctttcggt ggcccaacca ttgacttgat cccgaaatca     6540

gctcgtaagt atttcgaaga aaaagcgctg gattattaca ggtcgattgc taagagactc     6600

aactccatca ccactgctaa cccctcttca ttcaacaagt acattggaga atacaagcag     6660

aaactgatcc gcaagtaccg tttcgtggtc gagagttcgg gtgaagttac tgtgaaccgc     6720

aacaagttcg tcgagctgta caacgaattg acacaaatct tcacggagtt caactacgcc     6780

aaaatttaca acgtgcaaaa ccgtaagatc gcgctctcta acgtctacac cccggttacc     6840

gctaacatct tggacgataa cgtctacgac attcagaacg gtttcaacat cccaaagtcg     6900

aacctcaacg ttttgttcat gggtcaaaac ttgtcccgca accccgccct gcgtaaggtg     6960

aacccagaga acatgttgta cctgttcacc aaattctgcc acaaggccat cgacggtcag     7020

tctctagacc aaggaggatg ggaactccag caaggtggcc agggtggagg tgctggcacc     7080

ctggactgtc gcgaactgct cgttaagaac actgatctcc cattcattgg cgacatctct     7140

gatgtgaaaa cagacatttt cctgcgtaag gatatcaacg aggaaacgga ggtcatctac     7200

taccctgaca acgtctcggt tgatcaggtt atcttgtcaa agaacaccag tgaacatggc     7260

caactggact tgctgtaccc ctcaattgat tccgagagcg aaatcctgcc aggagagaac     7320

caggttttct acgacaacag gacacaaaac gtggattacc tcaacagcta ctactacctg     7380

gagtcgcaga agctctccga caacgtcgaa gatttcacat ttacgagatc aatcgaggag     7440

gctttggaca acagtgccaa agtctacacc tacttcccta ctctggcaaa caaggtgaac     7500

gcgggtgtcc aaggcggact cttcttgatg tgggctaacg acgttgtgga agatttcaca     7560

acgaacatct tgcgcaaaga caccctggat aagatcagcg atgtctctgc catcattcca     7620

tacattggcc cggcactgaa catctctaac tcagttcgcc gtggcaactt cactgaggca     7680

ttcgcggtca caggagttac gatcctcttg gaggctttcc cggagttcac aatccccgca     7740

ctgggcgcgt tcgttatcta ctccaaagtg caggagcgca acgaaatcat taagactatc     7800

gacaactgcc tggagcaaag gatcaaaaga tggaaggatt cgtacgaatg gatgatgggt     7860

acctggctct cccgtatcat tacgcagttc aacaacatca gctaccaaat gtacgactct     7920

ctcaactacc aggctggtgc catcaaggcc aaaattgact tggagtacaa gaaatacagt     7980

ggctcggata aagagaacat caagagtcaa gtcgaaaacc tgaaaaactc actcgacgtt     8040

aagatcagtg aggcaatgaa caacatcaac aagttcattc gcgaatgttc cgttacctac     8100

ctcttcaaaa acatgttgcc aaaggtcatc gacgagctga acgaatttga tcgtaacact     8160

aaggcgaaac tgattaacct catcgactca cacaacatca ttttggtggg cgaagtcgat     8220

aagctgaaag ccaaggtgaa caacagtttc cagaacacaa tccctttcaa cattttctca     8280

tacacgaaca acagtctgct caaggacatc attaacgagt acttcaacaa cattaacgat     8340

agcaaaatcc tgtcactgca gaaccgtaag aacacactgg tcgatactag tggatacaac     8400

gccgaagtct ctgaggaagg tgacgtgcag ctgaacccta tcttcccctt cgacttcaaa     8460

ttgggctcca gcggagagga taggggcaag gtcatcgtca cccagaacga gaacatcgtc     8520

tacaactcaa tgtacgaatc cttcagcatc tctttctgga tcaggattaa caagtgggtg     8580

agcaacctgc ccggttacac aatcattgac tctgtcaaga acaactcagg ttggagtatc     8640

ggcatcattt ctaacttctt ggtcttcacc ctgaagcaga acgaggactc ggaacaatcc     8700

attaacttct catacgatat cagtaacaac gctccaggtt acaacaagtg gttcttcgtt     8760

accgtgacta acaacatgat gggtaacatg aaaatttaca tcaacggcaa gctcattgac     8820

accatcaaag tgaaggagtt gactggtatt aacttctcca aaacaatcac gtttgaaatt     8880

aacaagatcc ctgacaccgg cctgatcact tcagacagtg ataacatcaa catgtggatt     8940

agggatttct acatcttcgc caaggagctc gacggaaagg atattaacat cctcttcaac     9000

agcttgcagt acaccaacgt cgttaaagac tactggggta acgatttgag atacaacaag     9060

gagtactaca tggtcaacat cgactacctg aacaggtaca tgtacgctaa ctcccgccaa     9120

atcgtgttca acaccaggag aaacaacaac gacttcaacg agggttacaa aatcattatc     9180

aagcgcatcc gtggcaacac caacgatact agggtgagag gtggcgacat tctgtacttc     9240

gatatgacta tcaacaacaa agcctacaac ttgttcatga aaaacgagac aatgtacgcc     9300

gacaaccata gcacggagga tatttacgca atcggactga gggaacagac aaaggacatc     9360

aacgataaca ttatcttcca gatccaacct atgaacaaca cgtactacta cgcttcgcaa     9420

atcttcaagt ccaacttcaa cggagaaaac atttcgggta tctgttccat tggcacatac     9480

cgcttccgtc tgggtggtga ctggtatcgt cacaactacc tcgttcccac cgtgaagcag     9540

ggtaactacg cttctttgct ggagtcgact tccacgcact ggggattcgt tcctgtgtca     9600

gagggcgctg gctaccctta cgatgttccc gactacgctg gttgggaact ccagcaaggt     9660

gcaggatggt cccaccctca attcgagaag ggtgccggat ggagtcaccc acagttcgag     9720

aaaggcgctg gatggagtca cccacagttc gagaaataat tagttgatgc atagttaatt     9780

agatagctcg aggcatgcgg taccaagatt ggatctagat gcatagttaa ttagatagct     9840

cgaggcatgc ggtaccaagc ttgtcgagaa gtactagagg atcataatca gccataccac     9900

atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca     9960

taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata    10020

aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg    10080

tttgtccaaa ctcatcaatg tatcttatca tgtctggatc tgatcactgc ttgagcctag    10140

gagatccgaa ccagataagt gaaatctagt tccaaactat tttgtcattt ttaattttcg    10200

tattagctta cgacgctaca cccagttccc atctattttg tcactcttcc ctaaataatc    10260

cttaaaaact ccatttccac ccctcccagt tcccaactat tttgtccgcc cacagcgggg    10320

catttttctt cctgttatgt ttttaatcaa acatcctgcc aactccatgt gacaaaccgt    10380

catcttcggc tactttttct ctgtcacaga atgaaaattt ttctgtcatc tcttcgttat    10440

taatgtttgt aattgactga atatcaacgc ttatttgcag cctgaatggc gaatgg        10496


<210>  42
<211>  1889
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein construct

<400>  42

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ala Gly His His His His His His His His His 
            20                  25                  30          


His His Asp Val Gly Trp Glu Leu Gln Arg Arg Pro Leu Asn Cys Ile 
        35                  40                  45              


Val Ala Val Ser Gln Asn Met Gly Ile Gly Lys Asn Gly Asp Leu Pro 
    50                  55                  60                  


Trp Pro Pro Leu Arg Asn Glu Phe Lys Tyr Phe Gln Arg Met Thr Thr 
65                  70                  75                  80  


Thr Ser Ser Val Glu Gly Lys Gln Asn Leu Val Ile Met Gly Arg Lys 
                85                  90                  95      


Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg Leu Leu Lys Asp Arg Ile 
            100                 105                 110         


Asn Ile Val Leu Ser Arg Glu Leu Lys Glu Pro Pro Arg Gly Ala His 
        115                 120                 125             


Phe Leu Ala Lys Ser Leu Asp Asp Ala Leu Arg Leu Ile Glu Gln Pro 
    130                 135                 140                 


Glu Leu Ala Ser Lys Val Asp Met Val Trp Ile Val Gly Gly Ser Ser 
145                 150                 155                 160 


Val Tyr Gln Glu Ala Met Asn Gln Pro Gly His Leu Arg Leu Phe Val 
                165                 170                 175     


Thr Arg Ile Met Gln Glu Phe Glu Ser Asp Thr Phe Phe Pro Glu Ile 
            180                 185                 190         


Asp Leu Gly Lys Tyr Lys Leu Leu Pro Glu Tyr Pro Gly Val Leu Ser 
        195                 200                 205             


Glu Val Gln Glu Glu Lys Gly Ile Lys Tyr Lys Phe Glu Val Tyr Glu 
    210                 215                 220                 


Lys Lys Asp Gly Ala Ser Gly Phe Ala Asn Glu Leu Gly Pro Arg Leu 
225                 230                 235                 240 


Met Gly Lys Gly Ala Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
                245                 250                 255     


Gly Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            260                 265                 270         


Gln Ser Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile 
        275                 280                 285             


Asp Ser Leu Tyr His Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu 
    290                 295                 300                 


Arg Glu Leu Val Ala Arg Val Gln Asp Gly Gly Ser Thr Ala Tyr Lys 
305                 310                 315                 320 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Phe Ser Arg Ser 
                325                 330                 335     


Thr Met Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile 
            340                 345                 350         


Tyr Tyr Cys Ala Ala Lys Ser Thr Ile Ser Thr Pro Leu Ser Trp Gly 
        355                 360                 365             


Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro 
    370                 375                 380                 


Gln Ser Ser Gly Gly Gly Ala Ala Ala Gly Ser Gly Gly Gly Ser Gln 
385                 390                 395                 400 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                405                 410                 415     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe His Ala Tyr Tyr 
            420                 425                 430         


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        435                 440                 445             


His Ile Gly Asn Gly Gly Ile Ile Thr Arg Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
465                 470                 475                 480 


Gln Met Thr Asn Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr 
                485                 490                 495     


Leu Gly Thr Arg Asp Asp Leu Gly Pro Glu Arg Gly Gln Gly Thr Gln 
            500                 505                 510         


Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Gly Ala Gly 
        515                 520                 525             


Gln Gly Ala Gly Ala Gly Pro Ile Thr Ile Asn Asn Phe Asn Tyr Ser 
    530                 535                 540                 


Asp Pro Val Asp Asn Lys Asn Ile Leu Tyr Leu Asp Thr His Leu Asn 
545                 550                 555                 560 


Thr Leu Ala Asn Glu Pro Glu Lys Ala Phe Arg Ile Thr Gly Asn Ile 
                565                 570                 575     


Trp Val Ile Pro Asp Arg Phe Ser Arg Asn Ser Asn Pro Asn Leu Asn 
            580                 585                 590         


Lys Pro Pro Arg Val Thr Ser Pro Lys Ser Gly Tyr Tyr Asp Pro Asn 
        595                 600                 605             


Tyr Leu Ser Thr Asp Ser Asp Lys Asp Pro Phe Leu Lys Glu Ile Ile 
    610                 615                 620                 


Lys Leu Phe Lys Arg Ile Asn Ser Arg Glu Ile Gly Glu Glu Leu Ile 
625                 630                 635                 640 


Tyr Arg Leu Ser Thr Asp Ile Pro Phe Pro Gly Asn Asn Asn Thr Pro 
                645                 650                 655     


Ile Asn Thr Phe Asp Phe Asp Val Asp Phe Asn Ser Val Asp Val Lys 
            660                 665                 670         


Thr Arg Gln Gly Asn Asn Trp Val Lys Thr Gly Ser Ile Asn Pro Ser 
        675                 680                 685             


Val Ile Ile Thr Gly Pro Arg Glu Asn Ile Ile Asp Pro Glu Thr Ser 
    690                 695                 700                 


Thr Phe Lys Leu Thr Asn Asn Thr Phe Ala Ala Gln Glu Gly Phe Gly 
705                 710                 715                 720 


Ala Leu Ser Ile Ile Ser Ile Ser Pro Arg Phe Met Leu Thr Tyr Ser 
                725                 730                 735     


Asn Ala Thr Asn Asp Val Gly Glu Gly Arg Phe Ser Lys Ser Glu Phe 
            740                 745                 750         


Cys Met Asp Pro Ile Leu Ile Leu Met His Ala Leu Asn Gly Ala Met 
        755                 760                 765             


His Asn Leu Tyr Gly Ile Ala Ile Pro Asn Asp Gln Thr Ile Ser Ser 
    770                 775                 780                 


Val Thr Ser Asn Ile Phe Tyr Ser Gln Tyr Asn Val Lys Leu Glu Tyr 
785                 790                 795                 800 


Ala Glu Ile Tyr Ala Phe Gly Gly Pro Thr Ile Asp Leu Ile Pro Lys 
                805                 810                 815     


Ser Ala Arg Lys Tyr Phe Glu Glu Lys Ala Leu Asp Tyr Tyr Arg Ser 
            820                 825                 830         


Ile Ala Lys Arg Leu Asn Ser Ile Thr Thr Ala Asn Pro Ser Ser Phe 
        835                 840                 845             


Asn Lys Tyr Ile Gly Glu Tyr Lys Gln Lys Leu Ile Arg Lys Tyr Arg 
    850                 855                 860                 


Phe Val Val Glu Ser Ser Gly Glu Val Thr Val Asn Arg Asn Lys Phe 
865                 870                 875                 880 


Val Glu Leu Tyr Asn Glu Leu Thr Gln Ile Phe Thr Glu Phe Asn Tyr 
                885                 890                 895     


Ala Lys Ile Tyr Asn Val Gln Asn Arg Lys Ile Ala Leu Ser Asn Val 
            900                 905                 910         


Tyr Thr Pro Val Thr Ala Asn Ile Leu Asp Asp Asn Val Tyr Asp Ile 
        915                 920                 925             


Gln Asn Gly Phe Asn Ile Pro Lys Ser Asn Leu Asn Val Leu Phe Met 
    930                 935                 940                 


Gly Gln Asn Leu Ser Arg Asn Pro Ala Leu Arg Lys Val Asn Pro Glu 
945                 950                 955                 960 


Asn Met Leu Tyr Leu Phe Thr Lys Phe Cys His Lys Ala Ile Asp Gly 
                965                 970                 975     


Gln Ser Leu Asp Gln Gly Gly Trp Glu Leu Gln Gln Gly Gly Gln Gly 
            980                 985                 990         


Gly Gly Ala Gly Thr Leu Asp Cys  Arg Glu Leu Leu Val  Lys Asn Thr 
        995                 1000                 1005             


Asp Leu  Pro Phe Ile Gly Asp  Ile Ser Asp Val Lys  Thr Asp Ile 
    1010                 1015                 1020             


Phe Leu  Arg Lys Asp Ile Asn  Glu Glu Thr Glu Val  Ile Tyr Tyr 
    1025                 1030                 1035             


Pro Asp  Asn Val Ser Val Asp  Gln Val Ile Leu Ser  Lys Asn Thr 
    1040                 1045                 1050             


Ser Glu  His Gly Gln Leu Asp  Leu Leu Tyr Pro Ser  Ile Asp Ser 
    1055                 1060                 1065             


Glu Ser  Glu Ile Leu Pro Gly  Glu Asn Gln Val Phe  Tyr Asp Asn 
    1070                 1075                 1080             


Arg Thr  Gln Asn Val Asp Tyr  Leu Asn Ser Tyr Tyr  Tyr Leu Glu 
    1085                 1090                 1095             


Ser Gln  Lys Leu Ser Asp Asn  Val Glu Asp Phe Thr  Phe Thr Arg 
    1100                 1105                 1110             


Ser Ile  Glu Glu Ala Leu Asp  Asn Ser Ala Lys Val  Tyr Thr Tyr 
    1115                 1120                 1125             


Phe Pro  Thr Leu Ala Asn Lys  Val Asn Ala Gly Val  Gln Gly Gly 
    1130                 1135                 1140             


Leu Phe  Leu Met Trp Ala Asn  Asp Val Val Glu Asp  Phe Thr Thr 
    1145                 1150                 1155             


Asn Ile  Leu Arg Lys Asp Thr  Leu Asp Lys Ile Ser  Asp Val Ser 
    1160                 1165                 1170             


Ala Ile  Ile Pro Tyr Ile Gly  Pro Ala Leu Asn Ile  Ser Asn Ser 
    1175                 1180                 1185             


Val Arg  Arg Gly Asn Phe Thr  Glu Ala Phe Ala Val  Thr Gly Val 
    1190                 1195                 1200             


Thr Ile  Leu Leu Glu Ala Phe  Pro Glu Phe Thr Ile  Pro Ala Leu 
    1205                 1210                 1215             


Gly Ala  Phe Val Ile Tyr Ser  Lys Val Gln Glu Arg  Asn Glu Ile 
    1220                 1225                 1230             


Ile Lys  Thr Ile Asp Asn Cys  Leu Glu Gln Arg Ile  Lys Arg Trp 
    1235                 1240                 1245             


Lys Asp  Ser Tyr Glu Trp Met  Met Gly Thr Trp Leu  Ser Arg Ile 
    1250                 1255                 1260             


Ile Thr  Gln Phe Asn Asn Ile  Ser Tyr Gln Met Tyr  Asp Ser Leu 
    1265                 1270                 1275             


Asn Tyr  Gln Ala Gly Ala Ile  Lys Ala Lys Ile Asp  Leu Glu Tyr 
    1280                 1285                 1290             


Lys Lys  Tyr Ser Gly Ser Asp  Lys Glu Asn Ile Lys  Ser Gln Val 
    1295                 1300                 1305             


Glu Asn  Leu Lys Asn Ser Leu  Asp Val Lys Ile Ser  Glu Ala Met 
    1310                 1315                 1320             


Asn Asn  Ile Asn Lys Phe Ile  Arg Glu Cys Ser Val  Thr Tyr Leu 
    1325                 1330                 1335             


Phe Lys  Asn Met Leu Pro Lys  Val Ile Asp Glu Leu  Asn Glu Phe 
    1340                 1345                 1350             


Asp Arg  Asn Thr Lys Ala Lys  Leu Ile Asn Leu Ile  Asp Ser His 
    1355                 1360                 1365             


Asn Ile  Ile Leu Val Gly Glu  Val Asp Lys Leu Lys  Ala Lys Val 
    1370                 1375                 1380             


Asn Asn  Ser Phe Gln Asn Thr  Ile Pro Phe Asn Ile  Phe Ser Tyr 
    1385                 1390                 1395             


Thr Asn  Asn Ser Leu Leu Lys  Asp Ile Ile Asn Glu  Tyr Phe Asn 
    1400                 1405                 1410             


Asn Ile  Asn Asp Ser Lys Ile  Leu Ser Leu Gln Asn  Arg Lys Asn 
    1415                 1420                 1425             


Thr Leu  Val Asp Thr Ser Gly  Tyr Asn Ala Glu Val  Ser Glu Glu 
    1430                 1435                 1440             


Gly Asp  Val Gln Leu Asn Pro  Ile Phe Pro Phe Asp  Phe Lys Leu 
    1445                 1450                 1455             


Gly Ser  Ser Gly Glu Asp Arg  Gly Lys Val Ile Val  Thr Gln Asn 
    1460                 1465                 1470             


Glu Asn  Ile Val Tyr Asn Ser  Met Tyr Glu Ser Phe  Ser Ile Ser 
    1475                 1480                 1485             


Phe Trp  Ile Arg Ile Asn Lys  Trp Val Ser Asn Leu  Pro Gly Tyr 
    1490                 1495                 1500             


Thr Ile  Ile Asp Ser Val Lys  Asn Asn Ser Gly Trp  Ser Ile Gly 
    1505                 1510                 1515             


Ile Ile  Ser Asn Phe Leu Val  Phe Thr Leu Lys Gln  Asn Glu Asp 
    1520                 1525                 1530             


Ser Glu  Gln Ser Ile Asn Phe  Ser Tyr Asp Ile Ser  Asn Asn Ala 
    1535                 1540                 1545             


Pro Gly  Tyr Asn Lys Trp Phe  Phe Val Thr Val Thr  Asn Asn Met 
    1550                 1555                 1560             


Met Gly  Asn Met Lys Ile Tyr  Ile Asn Gly Lys Leu  Ile Asp Thr 
    1565                 1570                 1575             


Ile Lys  Val Lys Glu Leu Thr  Gly Ile Asn Phe Ser  Lys Thr Ile 
    1580                 1585                 1590             


Thr Phe  Glu Ile Asn Lys Ile  Pro Asp Thr Gly Leu  Ile Thr Ser 
    1595                 1600                 1605             


Asp Ser  Asp Asn Ile Asn Met  Trp Ile Arg Asp Phe  Tyr Ile Phe 
    1610                 1615                 1620             


Ala Lys  Glu Leu Asp Gly Lys  Asp Ile Asn Ile Leu  Phe Asn Ser 
    1625                 1630                 1635             


Leu Gln  Tyr Thr Asn Val Val  Lys Asp Tyr Trp Gly  Asn Asp Leu 
    1640                 1645                 1650             


Arg Tyr  Asn Lys Glu Tyr Tyr  Met Val Asn Ile Asp  Tyr Leu Asn 
    1655                 1660                 1665             


Arg Tyr  Met Tyr Ala Asn Ser  Arg Gln Ile Val Phe  Asn Thr Arg 
    1670                 1675                 1680             


Arg Asn  Asn Asn Asp Phe Asn  Glu Gly Tyr Lys Ile  Ile Ile Lys 
    1685                 1690                 1695             


Arg Ile  Arg Gly Asn Thr Asn  Asp Thr Arg Val Arg  Gly Gly Asp 
    1700                 1705                 1710             


Ile Leu  Tyr Phe Asp Met Thr  Ile Asn Asn Lys Ala  Tyr Asn Leu 
    1715                 1720                 1725             


Phe Met  Lys Asn Glu Thr Met  Tyr Ala Asp Asn His  Ser Thr Glu 
    1730                 1735                 1740             


Asp Ile  Tyr Ala Ile Gly Leu  Arg Glu Gln Thr Lys  Asp Ile Asn 
    1745                 1750                 1755             


Asp Asn  Ile Ile Phe Gln Ile  Gln Pro Met Asn Asn  Thr Tyr Tyr 
    1760                 1765                 1770             


Tyr Ala  Ser Gln Ile Phe Lys  Ser Asn Phe Asn Gly  Glu Asn Ile 
    1775                 1780                 1785             


Ser Gly  Ile Cys Ser Ile Gly  Thr Tyr Arg Phe Arg  Leu Gly Gly 
    1790                 1795                 1800             


Asp Trp  Tyr Arg His Asn Tyr  Leu Val Pro Thr Val  Lys Gln Gly 
    1805                 1810                 1815             


Asn Tyr  Ala Ser Leu Leu Glu  Ser Thr Ser Thr His  Trp Gly Phe 
    1820                 1825                 1830             


Val Pro  Val Ser Glu Gly Ala  Gly Tyr Pro Tyr Asp  Val Pro Asp 
    1835                 1840                 1845             


Tyr Ala  Gly Trp Glu Leu Gln  Gln Gly Ala Gly Trp  Ser His Pro 
    1850                 1855                 1860             


Gln Phe  Glu Lys Gly Ala Gly  Trp Ser His Pro Gln  Phe Glu Lys 
    1865                 1870                 1875             


Gly Ala  Gly Trp Ser His Pro  Gln Phe Glu Lys 
    1880                 1885                 


<210>  43
<211>  9890
<212>  DNA
<213>  Artificial

<220>
<223>  DNA construct for molecular construction of fusion proteins

<400>  43
gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc       60

gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc      120

acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt      180

agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg      240

ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt      300

ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta      360

taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt      420

aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt tcggggaaat      480

gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg      540

agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa      600

catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac      660

ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac      720

atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt      780

ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc      840

gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca      900

ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc      960

ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag     1020

gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa     1080

ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg     1140

gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa     1200

ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg     1260

gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt     1320

gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt     1380

caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag     1440

cattggtaac tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat     1500

ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct     1560

taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct     1620

tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca     1680

gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc     1740

agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc     1800

aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct     1860

gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag     1920

gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc     1980

tacaccgaac tgagatacct acagcgtgag cattgagaaa gcgccacgct tcccgaaggg     2040

agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag     2100

cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt     2160

gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac     2220

gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg     2280

ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc     2340

cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcctgatg     2400

cggtattttc tccttacgca tctgtgcggt atttcacacc gcagaccagc cgcgtaacct     2460

ggcaaaatcg gttacggttg agtaataaat ggatgccctg cgtaagcggg tgtgggcgga     2520

caataaagtc ttaaactgaa caaaatagat ctaaactatg acaataaagt cttaaactag     2580

acagaatagt tgtaaactga aatcagtcca gttatgctgt gaaaaagcat actggacttt     2640

tgttatggct aaagcaaact cttcattttc tgaagtgcaa attgcccgtc gtattaaaga     2700

ggggcgtggc caagggcatg gtaaagacta tattcgcggc gttgtgacaa tttaccgaac     2760

aactccgcgg ccgggaagcc gatctcggct tgaacgaatt gttaggtggc ggtacttggg     2820

tcgatatcaa agtgcatcac ttcttcccgt atgcccaact ttgtatagag agccactgcg     2880

ggatcgtcac cgtaatctgc ttgcacgtag atcacataag caccaagcgc gttggcctca     2940

tgcttgagga gattgatgag cgcggtggca atgccctgcc tccggtgctc gccggagact     3000

gcgagatcat agatatagat ctcactacgc ggctgctcaa acctgggcag aacgtaagcc     3060

gcgagagcgc caacaaccgc ttcttggtcg aaggcagcaa gcgcgatgaa tgtcttacta     3120

cggagcaagt tcccgaggta atcggagtcc ggctgatgtt gggagtaggt ggctacgtct     3180

ccgaactcac gaccgaaaag atcaagagca gcccgcatgg atttgacttg gtcagggccg     3240

agcctacatg tgcgaatgat gcccatactt gagccaccta actttgtttt agggcgactg     3300

ccctgctgcg taacatcgtt gctgctgcgt aacatcgttg ctgctccata acatcaaaca     3360

tcgacccacg gcgtaacgcg cttgctgctt ggatgcccga ggcatagact gtacaaaaaa     3420

acagtcataa caagccatga aaaccgccac tgcgccgtta ccaccgctgc gttcggtcaa     3480

ggttctggac cagttgcgtg agcgcatacg ctacttgcat tacagtttac gaaccgaaca     3540

ggcttatgtc aactgggttc gtgccttcat ccgtttccac ggtgtgcgtc acccggcaac     3600

cttgggcagc agcgaagtcg aggcatttct gtcctggctg gcgaacgagc gcaaggtttc     3660

ggtctccacg catcgtcagg cattggcggc cttgctgttc ttctacggca aggtgctgtg     3720

cacggatctg ccctggcttc aggagatcgg aagacctcgg ccgtcgcggc gcttgccggt     3780

ggtgctgacc ccggatgaag tggttcgcat cctcggtttt ctggaaggcg agcatcgttt     3840

gttcgcccag gactctagct atagttctag tggttggcta cgtatactcc ggaatattaa     3900

tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt     3960

ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca     4020

ccatcgggcg cggatctcgg tccgttcgaa ccagaactct ggaagcttaa ctcctaaaaa     4080

accgccacca tgaaattctt agtcaacgtt gcccttgttt ttatggtcgt atacatttct     4140

tacatctatg cggccggaca ccaccaccac caccaccacc accaccacca cgacgtcggc     4200

tgggagctgc aaggcgccgg cgagcagaaa ctcatcagcg aagaagattt gggtgcggcc     4260

gctcaggttc aactcgtgga gagtggtggc ggactggtgc aatccggtgg cagcctgagg     4320

ctctcctgcg ctgcctctgg atcaatcgac agcctgtacc acatgggttg gtacaggcag     4380

gctcccggca aggagaggga actcgtcgcc agagttcaag acggaggtag tacagcatac     4440

aaggattcgg tcaaaggtcg cttcaccatt tctcgcgact tcagtcgttc gactatgtac     4500

ttgcagatga actcactgaa gcctgaggat acagccatct actactgtgc agcgaaatct     4560

accatttcaa ctccactgtc ttggggccag ggaacacaag tgacggtctc cagcgaaccg     4620

aagacgccta aaccccaatc ttcaggcgga ggtgcggccg ctggctcagg aggtggcagt     4680

caggtgcagc tggtggaatc cggtggtgga ctggtccagc ctggtggttc cctgcgtctg     4740

tcctgcgctg cttccggttt ccccttccac gcttactaca tgtcctgggt ccgccaggct     4800

cctggcaagg gattggaatg ggtgtcccac atcggcaacg gtggtatcat cacccgttac     4860

gctgactccg tgaagggccg tttcaccatc tcccgtgaca acgctaagaa caccctgtac     4920

ctgcagatga ccaacctgaa gcccgaggac accgctctgt actactgcac cctgggcacc     4980

cgtgacgacc tgggtcctga acgtggccag ggaacccaag tgaccgtgtc ctccgagccc     5040

aagaccccca agcctcaagg ggccggccag ggtgctggtg ctggaccgat caccatcaac     5100

aacttcaatt actcggatcc ggtggataac aagaacatcc tctacttgga cacacacttg     5160

aacacgctgg ctaacgagcc tgaaaaagct ttcaggatca ccggcaacat ttgggtcatt     5220

ccggataggt tcagcagaaa ctctaaccct aacttgaaca aacctcccag agtgacctca     5280

cctaagagtg gatactacga ccccaactac ctctcgactg actccgataa agaccccttc     5340

ctgaaggaga tcattaaact cttcaagcgc atcaactctc gtgaaattgg cgaggaattg     5400

atctaccgcc tgagtacaga catcccattc ccgggtaaca acaacacccc aatcaacact     5460

ttcgatttcg atgtcgattt caactcagtg gatgtcaaaa ccaggcaggg aaacaactgg     5520

gtgaagactg gtagcatcaa cccatctgtc atcattactg gcccgagaga gaacatcatt     5580

gaccctgaaa cctccacttt caagctgaca aacaacacgt tcgctgctca ggaaggcttc     5640

ggagcgttga gcatcatttc tatctcacct cgcttcatgc tgacatactc taacgctacg     5700

aacgacgtgg gagagggccg tttcagtaag tctgaattct gcatggaccc tattctgatc     5760

ctcatgcacg ctctcaacgg cgccatgcac aacttgtacg gaattgctat ccccaacgac     5820

cagaccattt ccagcgtgac tagcaacatc ttctactctc aatacaacgt caagctggag     5880

tacgcagaaa tctacgcttt cggtggccca accattgact tgatcccgaa atcagctcgt     5940

aagtatttcg aagaaaaagc gctggattat tacaggtcga ttgctaagag actcaactcc     6000

atcaccactg ctaacccctc ttcattcaac aagtacattg gagaatacaa gcagaaactg     6060

atccgcaagt accgtttcgt ggtcgagagt tcgggtgaag ttactgtgaa ccgcaacaag     6120

ttcgtcgagc tgtacaacga attgacacaa atcttcacgg agttcaacta cgccaaaatt     6180

tacaacgtgc aaaaccgtaa gatcgcgctc tctaacgtct acaccccggt taccgctaac     6240

atcttggacg ataacgtcta cgacattcag aacggtttca acatcccaaa gtcgaacctc     6300

aacgttttgt tcatgggtca aaacttgtcc cgcaaccccg ccctgcgtaa ggtgaaccca     6360

gagaacatgt tgtacctgtt caccaaattc tgccacaagg ccatcgacgg tcagtctcta     6420

gaccaaggag gatgggaact ccagcaaggt ggccagggtg gaggtgctgg caccctggac     6480

tgtcgcgaac tgctcgttaa gaacactgat ctcccattca ttggcgacat ctctgatgtg     6540

aaaacagaca ttttcctgcg taaggatatc aacgaggaaa cggaggtcat ctactaccct     6600

gacaacgtct cggttgatca ggttatcttg tcaaagaaca ccagtgaaca tggccaactg     6660

gacttgctgt acccctcaat tgattccgag agcgaaatcc tgccaggaga gaaccaggtt     6720

ttctacgaca acaggacaca aaacgtggat tacctcaaca gctactacta cctggagtcg     6780

cagaagctct ccgacaacgt cgaagatttc acatttacga gatcaatcga ggaggctttg     6840

gacaacagtg ccaaagtcta cacctacttc cctactctgg caaacaaggt gaacgcgggt     6900

gtccaaggcg gactcttctt gatgtgggct aacgacgttg tggaagattt cacaacgaac     6960

atcttgcgca aagacaccct ggataagatc agcgatgtct ctgccatcat tccatacatt     7020

ggcccggcac tgaacatctc taactcagtt cgccgtggca acttcactga ggcattcgcg     7080

gtcacaggag ttacgatcct cttggaggct ttcccggagt tcacaatccc cgcactgggc     7140

gcgttcgtta tctactccaa agtgcaggag cgcaacgaaa tcattaagac tatcgacaac     7200

tgcctggagc aaaggatcaa aagatggaag gattcgtacg aatggatgat gggtacctgg     7260

ctctcccgta tcattacgca gttcaacaac atcagctacc aaatgtacga ctctctcaac     7320

taccaggctg gtgccatcaa ggccaaaatt gacttggagt acaagaaata cagtggctcg     7380

gataaagaga acatcaagag tcaagtcgaa aacctgaaaa actcactcga cgttaagatc     7440

agtgaggcaa tgaacaacat caacaagttc attcgcgaat gttccgttac ctacctcttc     7500

aaaaacatgt tgccaaaggt catcgacgag ctgaacgaat ttgatcgtaa cactaaggcg     7560

aaactgatta acctcatcga ctcacacaac atcattttgg tgggcgaagt cgataagctg     7620

aaagccaagg tgaacaacag tttccagaac acaatccctt tcaacatttt ctcatacacg     7680

aacaacagtc tgctcaagga catcattaac gagtacttca acaacattaa cgatagcaaa     7740

atcctgtcac tgcagaaccg taagaacaca ctggtcgata ctagtggata caacgccgaa     7800

gtctctgagg aaggtgacgt gcagctgaac cctatcttcc ccttcgactt caaattgggc     7860

tccagcggag aggatagggg caaggtcatc gtcacccaga acgagaacat cgtctacaac     7920

tcaatgtacg aatccttcag catctctttc tggatcagga ttaacaagtg ggtgagcaac     7980

ctgcccggtt acacaatcat tgactctgtc aagaacaact caggttggag tatcggcatc     8040

atttctaact tcttggtctt caccctgaag cagaacgagg actcggaaca atccattaac     8100

ttctcatacg atatcagtaa caacgctcca ggttacaaca agtggttctt cgttaccgtg     8160

actaacaaca tgatgggtaa catgaaaatt tacatcaacg gcaagctcat tgacaccatc     8220

aaagtgaagg agttgactgg tattaacttc tccaaaacaa tcacgtttga aattaacaag     8280

atccctgaca ccggcctgat cacttcagac agtgataaca tcaacatgtg gattagggat     8340

ttctacatct tcgccaagga gctcgacgga aaggatatta acatcctctt caacagcttg     8400

cagtacacca acgtcgttaa agactactgg ggtaacgatt tgagatacaa caaggagtac     8460

tacatggtca acatcgacta cctgaacagg tacatgtacg ctaactcccg ccaaatcgtg     8520

ttcaacacca ggagaaacaa caacgacttc aacgagggtt acaaaatcat tatcaagcgc     8580

atccgtggca acaccaacga tactagggtg agaggtggcg acattctgta cttcgatatg     8640

actatcaaca acaaagccta caacttgttc atgaaaaacg agacaatgta cgccgacaac     8700

catagcacgg aggatattta cgcaatcgga ctgagggaac agacaaagga catcaacgat     8760

aacattatct tccagatcca acctatgaac aacacgtact actacgcttc gcaaatcttc     8820

aagtccaact tcaacggaga aaacatttcg ggtatctgtt ccattggcac ataccgcttc     8880

cgtctgggtg gtgactggta tcgtcacaac tacctcgttc ccaccgtgaa gcagggtaac     8940

tacgcttctt tgctggagtc gacttccacg cactggggat tcgttcctgt gtcagagggc     9000

gctggctacc cttacgatgt tcccgactac gctggttggg aactccagca aggtgcagga     9060

tggtcccacc ctcaattcga gaagggtgcc ggatggagtc acccacagtt cgagaaaggc     9120

gctggatgga gtcacccaca gttcgagaaa taattagttg atgcatagtt aattagatag     9180

ctcgaggcat gcggtaccaa gattggatct agatgcatag ttaattagat agctcgaggc     9240

atgcggtacc aagcttgtcg agaagtacta gaggatcata atcagccata ccacatttgt     9300

agaggtttta cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat     9360

gaatgcaatt gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa     9420

tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc     9480

caaactcatc aatgtatctt atcatgtctg gatctgatca ctgcttgagc ctaggagatc     9540

cgaaccagat aagtgaaatc tagttccaaa ctattttgtc atttttaatt ttcgtattag     9600

cttacgacgc tacacccagt tcccatctat tttgtcactc ttccctaaat aatccttaaa     9660

aactccattt ccacccctcc cagttcccaa ctattttgtc cgcccacagc ggggcatttt     9720

tcttcctgtt atgtttttaa tcaaacatcc tgccaactcc atgtgacaaa ccgtcatctt     9780

cggctacttt ttctctgtca cagaatgaaa atttttctgt catctcttcg ttattaatgt     9840

ttgtaattga ctgaatatca acgcttattt gcagcctgaa tggcgaatgg                9890


<210>  44
<211>  1687
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein construct

<400>  44

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ala Gly His His His His His His His His His 
            20                  25                  30          


His His Asp Val Gly Trp Glu Leu Gln Gly Ala Gly Glu Gln Lys Leu 
        35                  40                  45              


Ile Ser Glu Glu Asp Leu Gly Ala Ala Ala Gln Val Gln Leu Val Glu 
    50                  55                  60                  


Ser Gly Gly Gly Leu Val Gln Ser Gly Gly Ser Leu Arg Leu Ser Cys 
65                  70                  75                  80  


Ala Ala Ser Gly Ser Ile Asp Ser Leu Tyr His Met Gly Trp Tyr Arg 
                85                  90                  95      


Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Arg Val Gln Asp Gly 
            100                 105                 110         


Gly Ser Thr Ala Tyr Lys Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        115                 120                 125             


Arg Asp Phe Ser Arg Ser Thr Met Tyr Leu Gln Met Asn Ser Leu Lys 
    130                 135                 140                 


Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Lys Ser Thr Ile Ser 
145                 150                 155                 160 


Thr Pro Leu Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu 
                165                 170                 175     


Pro Lys Thr Pro Lys Pro Gln Ser Ser Gly Gly Gly Ala Ala Ala Gly 
            180                 185                 190         


Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
        195                 200                 205             


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    210                 215                 220                 


Pro Phe His Ala Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
225                 230                 235                 240 


Gly Leu Glu Trp Val Ser His Ile Gly Asn Gly Gly Ile Ile Thr Arg 
                245                 250                 255     


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
            260                 265                 270         


Lys Asn Thr Leu Tyr Leu Gln Met Thr Asn Leu Lys Pro Glu Asp Thr 
        275                 280                 285             


Ala Leu Tyr Tyr Cys Thr Leu Gly Thr Arg Asp Asp Leu Gly Pro Glu 
    290                 295                 300                 


Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro 
305                 310                 315                 320 


Lys Pro Gln Gly Ala Gly Gln Gly Ala Gly Ala Gly Pro Ile Thr Ile 
                325                 330                 335     


Asn Asn Phe Asn Tyr Ser Asp Pro Val Asp Asn Lys Asn Ile Leu Tyr 
            340                 345                 350         


Leu Asp Thr His Leu Asn Thr Leu Ala Asn Glu Pro Glu Lys Ala Phe 
        355                 360                 365             


Arg Ile Thr Gly Asn Ile Trp Val Ile Pro Asp Arg Phe Ser Arg Asn 
    370                 375                 380                 


Ser Asn Pro Asn Leu Asn Lys Pro Pro Arg Val Thr Ser Pro Lys Ser 
385                 390                 395                 400 


Gly Tyr Tyr Asp Pro Asn Tyr Leu Ser Thr Asp Ser Asp Lys Asp Pro 
                405                 410                 415     


Phe Leu Lys Glu Ile Ile Lys Leu Phe Lys Arg Ile Asn Ser Arg Glu 
            420                 425                 430         


Ile Gly Glu Glu Leu Ile Tyr Arg Leu Ser Thr Asp Ile Pro Phe Pro 
        435                 440                 445             


Gly Asn Asn Asn Thr Pro Ile Asn Thr Phe Asp Phe Asp Val Asp Phe 
    450                 455                 460                 


Asn Ser Val Asp Val Lys Thr Arg Gln Gly Asn Asn Trp Val Lys Thr 
465                 470                 475                 480 


Gly Ser Ile Asn Pro Ser Val Ile Ile Thr Gly Pro Arg Glu Asn Ile 
                485                 490                 495     


Ile Asp Pro Glu Thr Ser Thr Phe Lys Leu Thr Asn Asn Thr Phe Ala 
            500                 505                 510         


Ala Gln Glu Gly Phe Gly Ala Leu Ser Ile Ile Ser Ile Ser Pro Arg 
        515                 520                 525             


Phe Met Leu Thr Tyr Ser Asn Ala Thr Asn Asp Val Gly Glu Gly Arg 
    530                 535                 540                 


Phe Ser Lys Ser Glu Phe Cys Met Asp Pro Ile Leu Ile Leu Met His 
545                 550                 555                 560 


Ala Leu Asn Gly Ala Met His Asn Leu Tyr Gly Ile Ala Ile Pro Asn 
                565                 570                 575     


Asp Gln Thr Ile Ser Ser Val Thr Ser Asn Ile Phe Tyr Ser Gln Tyr 
            580                 585                 590         


Asn Val Lys Leu Glu Tyr Ala Glu Ile Tyr Ala Phe Gly Gly Pro Thr 
        595                 600                 605             


Ile Asp Leu Ile Pro Lys Ser Ala Arg Lys Tyr Phe Glu Glu Lys Ala 
    610                 615                 620                 


Leu Asp Tyr Tyr Arg Ser Ile Ala Lys Arg Leu Asn Ser Ile Thr Thr 
625                 630                 635                 640 


Ala Asn Pro Ser Ser Phe Asn Lys Tyr Ile Gly Glu Tyr Lys Gln Lys 
                645                 650                 655     


Leu Ile Arg Lys Tyr Arg Phe Val Val Glu Ser Ser Gly Glu Val Thr 
            660                 665                 670         


Val Asn Arg Asn Lys Phe Val Glu Leu Tyr Asn Glu Leu Thr Gln Ile 
        675                 680                 685             


Phe Thr Glu Phe Asn Tyr Ala Lys Ile Tyr Asn Val Gln Asn Arg Lys 
    690                 695                 700                 


Ile Ala Leu Ser Asn Val Tyr Thr Pro Val Thr Ala Asn Ile Leu Asp 
705                 710                 715                 720 


Asp Asn Val Tyr Asp Ile Gln Asn Gly Phe Asn Ile Pro Lys Ser Asn 
                725                 730                 735     


Leu Asn Val Leu Phe Met Gly Gln Asn Leu Ser Arg Asn Pro Ala Leu 
            740                 745                 750         


Arg Lys Val Asn Pro Glu Asn Met Leu Tyr Leu Phe Thr Lys Phe Cys 
        755                 760                 765             


His Lys Ala Ile Asp Gly Gln Ser Leu Asp Gln Gly Gly Trp Glu Leu 
    770                 775                 780                 


Gln Gln Gly Gly Gln Gly Gly Gly Ala Gly Thr Leu Asp Cys Arg Glu 
785                 790                 795                 800 


Leu Leu Val Lys Asn Thr Asp Leu Pro Phe Ile Gly Asp Ile Ser Asp 
                805                 810                 815     


Val Lys Thr Asp Ile Phe Leu Arg Lys Asp Ile Asn Glu Glu Thr Glu 
            820                 825                 830         


Val Ile Tyr Tyr Pro Asp Asn Val Ser Val Asp Gln Val Ile Leu Ser 
        835                 840                 845             


Lys Asn Thr Ser Glu His Gly Gln Leu Asp Leu Leu Tyr Pro Ser Ile 
    850                 855                 860                 


Asp Ser Glu Ser Glu Ile Leu Pro Gly Glu Asn Gln Val Phe Tyr Asp 
865                 870                 875                 880 


Asn Arg Thr Gln Asn Val Asp Tyr Leu Asn Ser Tyr Tyr Tyr Leu Glu 
                885                 890                 895     


Ser Gln Lys Leu Ser Asp Asn Val Glu Asp Phe Thr Phe Thr Arg Ser 
            900                 905                 910         


Ile Glu Glu Ala Leu Asp Asn Ser Ala Lys Val Tyr Thr Tyr Phe Pro 
        915                 920                 925             


Thr Leu Ala Asn Lys Val Asn Ala Gly Val Gln Gly Gly Leu Phe Leu 
    930                 935                 940                 


Met Trp Ala Asn Asp Val Val Glu Asp Phe Thr Thr Asn Ile Leu Arg 
945                 950                 955                 960 


Lys Asp Thr Leu Asp Lys Ile Ser Asp Val Ser Ala Ile Ile Pro Tyr 
                965                 970                 975     


Ile Gly Pro Ala Leu Asn Ile Ser Asn Ser Val Arg Arg Gly Asn Phe 
            980                 985                 990         


Thr Glu Ala Phe Ala Val Thr Gly  Val Thr Ile Leu Leu  Glu Ala Phe 
        995                 1000                 1005             


Pro Glu  Phe Thr Ile Pro Ala  Leu Gly Ala Phe Val  Ile Tyr Ser 
    1010                 1015                 1020             


Lys Val  Gln Glu Arg Asn Glu  Ile Ile Lys Thr Ile  Asp Asn Cys 
    1025                 1030                 1035             


Leu Glu  Gln Arg Ile Lys Arg  Trp Lys Asp Ser Tyr  Glu Trp Met 
    1040                 1045                 1050             


Met Gly  Thr Trp Leu Ser Arg  Ile Ile Thr Gln Phe  Asn Asn Ile 
    1055                 1060                 1065             


Ser Tyr  Gln Met Tyr Asp Ser  Leu Asn Tyr Gln Ala  Gly Ala Ile 
    1070                 1075                 1080             


Lys Ala  Lys Ile Asp Leu Glu  Tyr Lys Lys Tyr Ser  Gly Ser Asp 
    1085                 1090                 1095             


Lys Glu  Asn Ile Lys Ser Gln  Val Glu Asn Leu Lys  Asn Ser Leu 
    1100                 1105                 1110             


Asp Val  Lys Ile Ser Glu Ala  Met Asn Asn Ile Asn  Lys Phe Ile 
    1115                 1120                 1125             


Arg Glu  Cys Ser Val Thr Tyr  Leu Phe Lys Asn Met  Leu Pro Lys 
    1130                 1135                 1140             


Val Ile  Asp Glu Leu Asn Glu  Phe Asp Arg Asn Thr  Lys Ala Lys 
    1145                 1150                 1155             


Leu Ile  Asn Leu Ile Asp Ser  His Asn Ile Ile Leu  Val Gly Glu 
    1160                 1165                 1170             


Val Asp  Lys Leu Lys Ala Lys  Val Asn Asn Ser Phe  Gln Asn Thr 
    1175                 1180                 1185             


Ile Pro  Phe Asn Ile Phe Ser  Tyr Thr Asn Asn Ser  Leu Leu Lys 
    1190                 1195                 1200             


Asp Ile  Ile Asn Glu Tyr Phe  Asn Asn Ile Asn Asp  Ser Lys Ile 
    1205                 1210                 1215             


Leu Ser  Leu Gln Asn Arg Lys  Asn Thr Leu Val Asp  Thr Ser Gly 
    1220                 1225                 1230             


Tyr Asn  Ala Glu Val Ser Glu  Glu Gly Asp Val Gln  Leu Asn Pro 
    1235                 1240                 1245             


Ile Phe  Pro Phe Asp Phe Lys  Leu Gly Ser Ser Gly  Glu Asp Arg 
    1250                 1255                 1260             


Gly Lys  Val Ile Val Thr Gln  Asn Glu Asn Ile Val  Tyr Asn Ser 
    1265                 1270                 1275             


Met Tyr  Glu Ser Phe Ser Ile  Ser Phe Trp Ile Arg  Ile Asn Lys 
    1280                 1285                 1290             


Trp Val  Ser Asn Leu Pro Gly  Tyr Thr Ile Ile Asp  Ser Val Lys 
    1295                 1300                 1305             


Asn Asn  Ser Gly Trp Ser Ile  Gly Ile Ile Ser Asn  Phe Leu Val 
    1310                 1315                 1320             


Phe Thr  Leu Lys Gln Asn Glu  Asp Ser Glu Gln Ser  Ile Asn Phe 
    1325                 1330                 1335             


Ser Tyr  Asp Ile Ser Asn Asn  Ala Pro Gly Tyr Asn  Lys Trp Phe 
    1340                 1345                 1350             


Phe Val  Thr Val Thr Asn Asn  Met Met Gly Asn Met  Lys Ile Tyr 
    1355                 1360                 1365             


Ile Asn  Gly Lys Leu Ile Asp  Thr Ile Lys Val Lys  Glu Leu Thr 
    1370                 1375                 1380             


Gly Ile  Asn Phe Ser Lys Thr  Ile Thr Phe Glu Ile  Asn Lys Ile 
    1385                 1390                 1395             


Pro Asp  Thr Gly Leu Ile Thr  Ser Asp Ser Asp Asn  Ile Asn Met 
    1400                 1405                 1410             


Trp Ile  Arg Asp Phe Tyr Ile  Phe Ala Lys Glu Leu  Asp Gly Lys 
    1415                 1420                 1425             


Asp Ile  Asn Ile Leu Phe Asn  Ser Leu Gln Tyr Thr  Asn Val Val 
    1430                 1435                 1440             


Lys Asp  Tyr Trp Gly Asn Asp  Leu Arg Tyr Asn Lys  Glu Tyr Tyr 
    1445                 1450                 1455             


Met Val  Asn Ile Asp Tyr Leu  Asn Arg Tyr Met Tyr  Ala Asn Ser 
    1460                 1465                 1470             


Arg Gln  Ile Val Phe Asn Thr  Arg Arg Asn Asn Asn  Asp Phe Asn 
    1475                 1480                 1485             


Glu Gly  Tyr Lys Ile Ile Ile  Lys Arg Ile Arg Gly  Asn Thr Asn 
    1490                 1495                 1500             


Asp Thr  Arg Val Arg Gly Gly  Asp Ile Leu Tyr Phe  Asp Met Thr 
    1505                 1510                 1515             


Ile Asn  Asn Lys Ala Tyr Asn  Leu Phe Met Lys Asn  Glu Thr Met 
    1520                 1525                 1530             


Tyr Ala  Asp Asn His Ser Thr  Glu Asp Ile Tyr Ala  Ile Gly Leu 
    1535                 1540                 1545             


Arg Glu  Gln Thr Lys Asp Ile  Asn Asp Asn Ile Ile  Phe Gln Ile 
    1550                 1555                 1560             


Gln Pro  Met Asn Asn Thr Tyr  Tyr Tyr Ala Ser Gln  Ile Phe Lys 
    1565                 1570                 1575             


Ser Asn  Phe Asn Gly Glu Asn  Ile Ser Gly Ile Cys  Ser Ile Gly 
    1580                 1585                 1590             


Thr Tyr  Arg Phe Arg Leu Gly  Gly Asp Trp Tyr Arg  His Asn Tyr 
    1595                 1600                 1605             


Leu Val  Pro Thr Val Lys Gln  Gly Asn Tyr Ala Ser  Leu Leu Glu 
    1610                 1615                 1620             


Ser Thr  Ser Thr His Trp Gly  Phe Val Pro Val Ser  Glu Gly Ala 
    1625                 1630                 1635             


Gly Tyr  Pro Tyr Asp Val Pro  Asp Tyr Ala Gly Trp  Glu Leu Gln 
    1640                 1645                 1650             


Gln Gly  Ala Gly Trp Ser His  Pro Gln Phe Glu Lys  Gly Ala Gly 
    1655                 1660                 1665             


Trp Ser  His Pro Gln Phe Glu  Lys Gly Ala Gly Trp  Ser His Pro 
    1670                 1675                 1680             


Gln Phe  Glu Lys 
    1685         


<210>  45
<211>  10496
<212>  DNA
<213>  Artificial

<220>
<223>  DNA construct for molecular construction of fusion proteins

<400>  45
gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc       60

gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc      120

acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt      180

agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg      240

ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt      300

ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta      360

taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt      420

aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt tcggggaaat      480

gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg      540

agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa      600

catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac      660

ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac      720

atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt      780

ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc      840

gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca      900

ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc      960

ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag     1020

gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa     1080

ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg     1140

gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa     1200

ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg     1260

gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt     1320

gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt     1380

caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag     1440

cattggtaac tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat     1500

ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct     1560

taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct     1620

tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca     1680

gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc     1740

agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc     1800

aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct     1860

gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag     1920

gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc     1980

tacaccgaac tgagatacct acagcgtgag cattgagaaa gcgccacgct tcccgaaggg     2040

agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag     2100

cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt     2160

gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac     2220

gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg     2280

ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc     2340

cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcctgatg     2400

cggtattttc tccttacgca tctgtgcggt atttcacacc gcagaccagc cgcgtaacct     2460

ggcaaaatcg gttacggttg agtaataaat ggatgccctg cgtaagcggg tgtgggcgga     2520

caataaagtc ttaaactgaa caaaatagat ctaaactatg acaataaagt cttaaactag     2580

acagaatagt tgtaaactga aatcagtcca gttatgctgt gaaaaagcat actggacttt     2640

tgttatggct aaagcaaact cttcattttc tgaagtgcaa attgcccgtc gtattaaaga     2700

ggggcgtggc caagggcatg gtaaagacta tattcgcggc gttgtgacaa tttaccgaac     2760

aactccgcgg ccgggaagcc gatctcggct tgaacgaatt gttaggtggc ggtacttggg     2820

tcgatatcaa agtgcatcac ttcttcccgt atgcccaact ttgtatagag agccactgcg     2880

ggatcgtcac cgtaatctgc ttgcacgtag atcacataag caccaagcgc gttggcctca     2940

tgcttgagga gattgatgag cgcggtggca atgccctgcc tccggtgctc gccggagact     3000

gcgagatcat agatatagat ctcactacgc ggctgctcaa acctgggcag aacgtaagcc     3060

gcgagagcgc caacaaccgc ttcttggtcg aaggcagcaa gcgcgatgaa tgtcttacta     3120

cggagcaagt tcccgaggta atcggagtcc ggctgatgtt gggagtaggt ggctacgtct     3180

ccgaactcac gaccgaaaag atcaagagca gcccgcatgg atttgacttg gtcagggccg     3240

agcctacatg tgcgaatgat gcccatactt gagccaccta actttgtttt agggcgactg     3300

ccctgctgcg taacatcgtt gctgctgcgt aacatcgttg ctgctccata acatcaaaca     3360

tcgacccacg gcgtaacgcg cttgctgctt ggatgcccga ggcatagact gtacaaaaaa     3420

acagtcataa caagccatga aaaccgccac tgcgccgtta ccaccgctgc gttcggtcaa     3480

ggttctggac cagttgcgtg agcgcatacg ctacttgcat tacagtttac gaaccgaaca     3540

ggcttatgtc aactgggttc gtgccttcat ccgtttccac ggtgtgcgtc acccggcaac     3600

cttgggcagc agcgaagtcg aggcatttct gtcctggctg gcgaacgagc gcaaggtttc     3660

ggtctccacg catcgtcagg cattggcggc cttgctgttc ttctacggca aggtgctgtg     3720

cacggatctg ccctggcttc aggagatcgg aagacctcgg ccgtcgcggc gcttgccggt     3780

ggtgctgacc ccggatgaag tggttcgcat cctcggtttt ctggaaggcg agcatcgttt     3840

gttcgcccag gactctagct atagttctag tggttggcta cgtatactcc ggaatattaa     3900

tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt     3960

ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca     4020

ccatcgggcg cggatctcgg tccgttcgaa ccagaactct ggaagcttaa ctcctaaaaa     4080

accgccacca tgaaattctt agtcaacgtt gcccttgttt ttatggtcgt atacatttct     4140

tacatctatg cggccggaca ccaccaccac caccaccacc accaccacca cgacgtcggc     4200

tgggagctgc aacgtcgtcc cctgaactgc atcgtggctg tgtcccagaa catgggtatc     4260

ggcaagaacg gcgacctgcc ctggcctcct ctgcgtaacg agttcaagta cttccagcgt     4320

atgaccacca cctcctccgt cgagggcaag cagaacctgg tcatcatggg tcgcaagacc     4380

tggttctcca tccccgagaa gaaccgtctg ctgaaggacc gtatcaacat cgtgctgtcc     4440

cgcgagctga aggaaccccc tcgtggtgct cacttcctgg ctaagtccct ggacgacgct     4500

ctgcgtctga tcgagcagcc tgagctggct tccaaggtgg acatggtctg gatcgtgggc     4560

ggttcctccg tgtaccaaga ggctatgaac cagcccggtc acttgcgtct gttcgtgacc     4620

cgtatcatgc aagagttcga gtccgacacc ttcttccccg aaatcgacct gggcaagtac     4680

aagctgctgc ccgagtaccc cggtgtcctg tccgaggtgc aagaggaaaa gggtatcaag     4740

tacaagttcg aggtgtacga gaagaaggac ggcgcttccg gtttcgctaa cgagctcggt     4800

cctcgtctga tgggaaaggg cgccggcgag cagaaactca tcagcgaaga agatttgggt     4860

gcggccgctc aggttcaact cgtggagagt ggtggcggac tggtgcaatc cggtggcagc     4920

ctgaggctct cctgcgctgc ctctggatca atcgacagcc tgtaccacat gggttggtac     4980

aggcaggctc ccggcaagga gagggaactc gtcgccagag ttcaagacgg aggtagtaca     5040

gcatacaagg attcggtcaa aggtcgcttc accatttctc gcgacttcag tcgttcgact     5100

atgtacttgc agatgaactc actgaagcct gaggatacag ccatctacta ctgtgcagcg     5160

aaatctacca tttcaactcc actgtcttgg ggccagggaa cacaagtgac ggtctccagc     5220

gaaccgaaga cgcctaaacc ccaatcttca ggcggaggtg cggccgctgg ctcaggaggt     5280

ggcagtcagg tgcagctggt ggaatccggt ggtggactgg tccagcctgg tggttccctg     5340

cgtctgtcct gcgctgcttc cggtttcccc ttccacgctt actacatgtc ctgggtccgc     5400

caggctcctg gcaagggatt ggaatgggtg tcccacatcg gcaacggtgg tatcatcacc     5460

cgttacgctg actccgtgaa gggccgtttc accatctccc gtgacaacgc taagaacacc     5520

ctgtacctgc agatgaccaa cctgaagccc gaggacaccg ctctgtacta ctgcaccctg     5580

ggcacccgtg acgacctggg tcctgaacgt ggccagggaa cccaagtgac cgtgtcctcc     5640

gagcccaaga cccccaagcc tcaaggggcc ggccagggtg ctggtgctgg accgatcacc     5700

atcaacaact tcaattactc ggatccggtg gataacaaga acatcctcta cttggacaca     5760

cacttgaaca cgctggctaa cgagcctgaa aaagctttca ggatcaccgg caacatttgg     5820

gtcattccgg ataggttcag cagaaactct aaccctaact tgaacaaacc tcccagagtg     5880

acctcaccta agagtggata ctacgacccc aactacctct cgactgactc cgataaagac     5940

cccttcctga aggagatcat taaactcttc aagcgcatca actctcgtga aattggcgag     6000

gaattgatct accgcctgag tacagacatc ccattcccgg gtaacaacaa caccccaatc     6060

aacactttcg atttcgatgt cgatttcaac tcagtggatg tcaaaaccag gcagggaaac     6120

aactgggtga agactggtag catcaaccca tctgtcatca ttactggccc gagagagaac     6180

atcattgacc ctgaaacctc cactttcaag ctgacaaaca acacgttcgc tgctcaggaa     6240

ggcttcggag cgttgagcat catttctatc tcacctcgct tcatgctgac atactctaac     6300

gctacgaacg acgtgggaga gggccgtttc agtaagtctg aattctgcat ggaccctatt     6360

ctgatcctca tgcacgctct caacggcgcc atgcacaact tgtacggaat tgctatcccc     6420

aacgaccaga ccatttccag cgtgactagc aacatcttct actctcaata caacgtcaag     6480

ctggagtacg cagaaatcta cgctttcggt ggcccaacca ttgacttgat cccgaaatca     6540

gctcgtaagt atttcgaaga aaaagcgctg gattattaca ggtcgattgc taagagactc     6600

aactccatca ccactgctaa cccctcttca ttcaacaagt acattggaga atacaagcag     6660

aaactgatcc gcaagtaccg tttcgtggtc gagagttcgg gtgaagttac tgtgaaccgc     6720

aacaagttcg tcgagctgta caacgaattg acacaaatct tcacggagtt caactacgcc     6780

aaaatttaca acgtgcaaaa ccgtaagatc gcgctctcta acgtctacac cccggttacc     6840

gctaacatct tggacgataa cgtctacgac attcagaacg gtttcaacat cccaaagtcg     6900

aacctcaacg ttttgttcat gggtcaaaac ttgtcccgca accccgccct gcgtaaggtg     6960

aacccagaga acatgttgta cctgttcacc aaattctgcc acaaggccat cgacggtcag     7020

tctctagacc aaggaggatg ggaactccag caaggtggcc agggtggagg tgctggcacc     7080

ctggactgtc gcgaactgct cgttaagaac actgatctcc cattcattgg cgacatctct     7140

gatgtgaaaa cagacatttt cctgcgtaag gatatcaacg aggaaacgga ggtcatctac     7200

taccctgaca acgtctcggt tgatcaggtt atcttgtcaa agaacaccag tgaacatggc     7260

caactggact tgctgtaccc ctcaattgat tccgagagcg aaatcctgcc aggagagaac     7320

caggttttct acgacaacag gacacaaaac gtggattacc tcaacagcta ctactacctg     7380

gagtcgcaga agctctccga caacgtcgaa gatttcacat ttacgagatc aatcgaggag     7440

gctttggaca acagtgccaa agtctacacc tacttcccta ctctggcaaa caaggtgaac     7500

gcgggtgtcc aaggcggact cttcttgatg tgggctaacg acgttgtgga agatttcaca     7560

acgaacatct tgcgcaaaga caccctggat aagatcagcg atgtctctgc catcattcca     7620

tacattggcc cggcactgaa catctctaac tcagttcgcc gtggcaactt cactgaggca     7680

ttcgcggtca caggagttac gatcctcttg gaggctttcc cggagttcac aatccccgca     7740

ctgggcgcgt tcgttatcta ctccaaagtg caggagcgca acgaaatcat taagactatc     7800

gacaactgcc tggagcaaag gatcaaaaga tggaaggatt cgtacgaatg gatgatgggt     7860

acctggctct cccgtatcat tacgcagttc aacaacatca gctaccaaat gtacgactct     7920

ctcaactacc aggctggtgc catcaaggcc aaaattgact tggagtacaa gaaatacagt     7980

ggctcggata aagagaacat caagagtcaa gtcgaaaacc tgaaaaactc actcgacgtt     8040

aagatcagtg aggcaatgaa caacatcaac aagttcattc gcgaatgttc cgttacctac     8100

ctcttcaaaa acatgttgcc aaaggtcatc gacgagctga acgaatttga tcgtaacact     8160

aaggcgaaac tgattaacct catcgactca cacaacatca ttttggtggg cgaagtcgat     8220

aagctgaaag ccaaggtgaa caacagtttc cagaacacaa tccctttcaa cattttctca     8280

tacacgaaca acagtctgct caaggacatc attaacgagt acttcaacaa cattaacgat     8340

agcaaaatcc tgtcactgca gaaccgtaag aacacactgg tcgatactag tggatacaac     8400

gccgaagtct ctgaggaagg tgacgtgcag ctgaacccta tcttcccctt cgacttcaaa     8460

ttgggctcca gcggagagga taggggcaag gtcatcgtca cccagaacga gaacatcgtc     8520

tacaactcaa tgtacgaatc cttcagcatc tctttctgga tcaggattaa caagtgggtg     8580

agcaacctgc ccggttacac aatcattgac tctgtcaaga acaactcagg ttggagtatc     8640

ggcatcattt ctaacttctt ggtcttcacc ctgaagcaga acgaggactc ggaacaatcc     8700

attaacttct catacgatat cagtaacaac gctccaggtt acaacaagtg gttcttcgtt     8760

accgtgacta acaacatgat gggtaacatg aaaatttaca tcaacggcaa gctcattgac     8820

accatcaaag tgaaggagtt gactggtatt aacttctcca aaacaatcac gtttgaaatt     8880

aacaagatcc ctgacaccgg cctgatcact tcagacagtg ataacatcaa catgtggatt     8940

agggatttct acatcttcgc caaggagctc gacggaaagg atattaacat cctcttcaac     9000

agcttgcagt acaccaacgt cgttaaagac tactggggta acgatttgag atacaacaag     9060

gagtactaca tggtcaacat cgactacctg aacaggtaca tgtacgctaa ctcccgccaa     9120

atcgtgttca acaccaggag aaacaacaac gacttcaacg agggttacaa aatcattatc     9180

aagcgcatcc gtggcaacac caacgatact agggtgagag gtggcgacat tctgtacttc     9240

gatatgacta tcaacaacaa agcctacaac ttgttcatga aaaacgagac aatgtacgcc     9300

gacaaccata gcacggagga tatttacgca atcggactga gggaacagac aaaggacatc     9360

aacgataaca ttatcttcca gatccaacct atgaacaaca cgtactacta cgcttcgcaa     9420

atcttcaagt ccaacttcaa cggagaaaac atttcgggta tctgttccat tggcacatac     9480

cgcttccgtc tgggtggtga ctggtatcgt cacaactacc tcgttcccac cgtgaagcag     9540

ggtaactacg cttctttgct ggagtcgact tccacgcact ggggattcgt tcctgtgtca     9600

gagggcgctg gctaccctta cgatgttccc gactacgctg gttgggaact ccagcaaggt     9660

gcaggatggt cccaccctca attcgagaag ggtgccggat ggagtcaccc acagttcgag     9720

aaaggcgctg gatggagtca cccacagttc gagaaataat tagttgatgc atagttaatt     9780

agatagctcg aggcatgcgg taccaagatt ggatctagat gcatagttaa ttagatagct     9840

cgaggcatgc ggtaccaagc ttgtcgagaa gtactagagg atcataatca gccataccac     9900

atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca     9960

taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata    10020

aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg    10080

tttgtccaaa ctcatcaatg tatcttatca tgtctggatc tgatcactgc ttgagcctag    10140

gagatccgaa ccagataagt gaaatctagt tccaaactat tttgtcattt ttaattttcg    10200

tattagctta cgacgctaca cccagttccc atctattttg tcactcttcc ctaaataatc    10260

cttaaaaact ccatttccac ccctcccagt tcccaactat tttgtccgcc cacagcgggg    10320

catttttctt cctgttatgt ttttaatcaa acatcctgcc aactccatgt gacaaaccgt    10380

catcttcggc tactttttct ctgtcacaga atgaaaattt ttctgtcatc tcttcgttat    10440

taatgtttgt aattgactga atatcaacgc ttatttgcag cctgaatggc gaatgg        10496


<210>  46
<211>  1889
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein construct

<400>  46

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ala Gly His His His His His His His His His 
            20                  25                  30          


His His Asp Val Gly Trp Glu Leu Gln Arg Arg Pro Leu Asn Cys Ile 
        35                  40                  45              


Val Ala Val Ser Gln Asn Met Gly Ile Gly Lys Asn Gly Asp Leu Pro 
    50                  55                  60                  


Trp Pro Pro Leu Arg Asn Glu Phe Lys Tyr Phe Gln Arg Met Thr Thr 
65                  70                  75                  80  


Thr Ser Ser Val Glu Gly Lys Gln Asn Leu Val Ile Met Gly Arg Lys 
                85                  90                  95      


Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg Leu Leu Lys Asp Arg Ile 
            100                 105                 110         


Asn Ile Val Leu Ser Arg Glu Leu Lys Glu Pro Pro Arg Gly Ala His 
        115                 120                 125             


Phe Leu Ala Lys Ser Leu Asp Asp Ala Leu Arg Leu Ile Glu Gln Pro 
    130                 135                 140                 


Glu Leu Ala Ser Lys Val Asp Met Val Trp Ile Val Gly Gly Ser Ser 
145                 150                 155                 160 


Val Tyr Gln Glu Ala Met Asn Gln Pro Gly His Leu Arg Leu Phe Val 
                165                 170                 175     


Thr Arg Ile Met Gln Glu Phe Glu Ser Asp Thr Phe Phe Pro Glu Ile 
            180                 185                 190         


Asp Leu Gly Lys Tyr Lys Leu Leu Pro Glu Tyr Pro Gly Val Leu Ser 
        195                 200                 205             


Glu Val Gln Glu Glu Lys Gly Ile Lys Tyr Lys Phe Glu Val Tyr Glu 
    210                 215                 220                 


Lys Lys Asp Gly Ala Ser Gly Phe Ala Asn Glu Leu Gly Pro Arg Leu 
225                 230                 235                 240 


Met Gly Lys Gly Ala Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
                245                 250                 255     


Gly Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            260                 265                 270         


Gln Ser Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile 
        275                 280                 285             


Asp Ser Leu Tyr His Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu 
    290                 295                 300                 


Arg Glu Leu Val Ala Arg Val Gln Asp Gly Gly Ser Thr Ala Tyr Lys 
305                 310                 315                 320 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Phe Ser Arg Ser 
                325                 330                 335     


Thr Met Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile 
            340                 345                 350         


Tyr Tyr Cys Ala Ala Lys Ser Thr Ile Ser Thr Pro Leu Ser Trp Gly 
        355                 360                 365             


Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro 
    370                 375                 380                 


Gln Ser Ser Gly Gly Gly Ala Ala Ala Gly Ser Gly Gly Gly Ser Gln 
385                 390                 395                 400 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                405                 410                 415     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe His Ala Tyr Tyr 
            420                 425                 430         


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        435                 440                 445             


His Ile Gly Asn Gly Gly Ile Ile Thr Arg Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
465                 470                 475                 480 


Gln Met Thr Asn Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr 
                485                 490                 495     


Leu Gly Thr Arg Asp Asp Leu Gly Pro Glu Arg Gly Gln Gly Thr Gln 
            500                 505                 510         


Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Gly Ala Gly 
        515                 520                 525             


Gln Gly Ala Gly Ala Gly Pro Ile Thr Ile Asn Asn Phe Asn Tyr Ser 
    530                 535                 540                 


Asp Pro Val Asp Asn Lys Asn Ile Leu Tyr Leu Asp Thr His Leu Asn 
545                 550                 555                 560 


Thr Leu Ala Asn Glu Pro Glu Lys Ala Phe Arg Ile Thr Gly Asn Ile 
                565                 570                 575     


Trp Val Ile Pro Asp Arg Phe Ser Arg Asn Ser Asn Pro Asn Leu Asn 
            580                 585                 590         


Lys Pro Pro Arg Val Thr Ser Pro Lys Ser Gly Tyr Tyr Asp Pro Asn 
        595                 600                 605             


Tyr Leu Ser Thr Asp Ser Asp Lys Asp Pro Phe Leu Lys Glu Ile Ile 
    610                 615                 620                 


Lys Leu Phe Lys Arg Ile Asn Ser Arg Glu Ile Gly Glu Glu Leu Ile 
625                 630                 635                 640 


Tyr Arg Leu Ser Thr Asp Ile Pro Phe Pro Gly Asn Asn Asn Thr Pro 
                645                 650                 655     


Ile Asn Thr Phe Asp Phe Asp Val Asp Phe Asn Ser Val Asp Val Lys 
            660                 665                 670         


Thr Arg Gln Gly Asn Asn Trp Val Lys Thr Gly Ser Ile Asn Pro Ser 
        675                 680                 685             


Val Ile Ile Thr Gly Pro Arg Glu Asn Ile Ile Asp Pro Glu Thr Ser 
    690                 695                 700                 


Thr Phe Lys Leu Thr Asn Asn Thr Phe Ala Ala Gln Glu Gly Phe Gly 
705                 710                 715                 720 


Ala Leu Ser Ile Ile Ser Ile Ser Pro Arg Phe Met Leu Thr Tyr Ser 
                725                 730                 735     


Asn Ala Thr Asn Asp Val Gly Glu Gly Arg Phe Ser Lys Ser Glu Phe 
            740                 745                 750         


Cys Met Asp Pro Ile Leu Ile Leu Met His Ala Leu Asn Gly Ala Met 
        755                 760                 765             


His Asn Leu Tyr Gly Ile Ala Ile Pro Asn Asp Gln Thr Ile Ser Ser 
    770                 775                 780                 


Val Thr Ser Asn Ile Phe Tyr Ser Gln Tyr Asn Val Lys Leu Glu Tyr 
785                 790                 795                 800 


Ala Glu Ile Tyr Ala Phe Gly Gly Pro Thr Ile Asp Leu Ile Pro Lys 
                805                 810                 815     


Ser Ala Arg Lys Tyr Phe Glu Glu Lys Ala Leu Asp Tyr Tyr Arg Ser 
            820                 825                 830         


Ile Ala Lys Arg Leu Asn Ser Ile Thr Thr Ala Asn Pro Ser Ser Phe 
        835                 840                 845             


Asn Lys Tyr Ile Gly Glu Tyr Lys Gln Lys Leu Ile Arg Lys Tyr Arg 
    850                 855                 860                 


Phe Val Val Glu Ser Ser Gly Glu Val Thr Val Asn Arg Asn Lys Phe 
865                 870                 875                 880 


Val Glu Leu Tyr Asn Glu Leu Thr Gln Ile Phe Thr Glu Phe Asn Tyr 
                885                 890                 895     


Ala Lys Ile Tyr Asn Val Gln Asn Arg Lys Ile Ala Leu Ser Asn Val 
            900                 905                 910         


Tyr Thr Pro Val Thr Ala Asn Ile Leu Asp Asp Asn Val Tyr Asp Ile 
        915                 920                 925             


Gln Asn Gly Phe Asn Ile Pro Lys Ser Asn Leu Asn Val Leu Phe Met 
    930                 935                 940                 


Gly Gln Asn Leu Ser Arg Asn Pro Ala Leu Arg Lys Val Asn Pro Glu 
945                 950                 955                 960 


Asn Met Leu Tyr Leu Phe Thr Lys Phe Cys His Lys Ala Ile Asp Gly 
                965                 970                 975     


Gln Ser Leu Asp Gln Gly Gly Trp Glu Leu Gln Gln Gly Gly Gln Gly 
            980                 985                 990         


Gly Gly Ala Gly Thr Leu Asp Cys  Arg Glu Leu Leu Val  Lys Asn Thr 
        995                 1000                 1005             


Asp Leu  Pro Phe Ile Gly Asp  Ile Ser Asp Val Lys  Thr Asp Ile 
    1010                 1015                 1020             


Phe Leu  Arg Lys Asp Ile Asn  Glu Glu Thr Glu Val  Ile Tyr Tyr 
    1025                 1030                 1035             


Pro Asp  Asn Val Ser Val Asp  Gln Val Ile Leu Ser  Lys Asn Thr 
    1040                 1045                 1050             


Ser Glu  His Gly Gln Leu Asp  Leu Leu Tyr Pro Ser  Ile Asp Ser 
    1055                 1060                 1065             


Glu Ser  Glu Ile Leu Pro Gly  Glu Asn Gln Val Phe  Tyr Asp Asn 
    1070                 1075                 1080             


Arg Thr  Gln Asn Val Asp Tyr  Leu Asn Ser Tyr Tyr  Tyr Leu Glu 
    1085                 1090                 1095             


Ser Gln  Lys Leu Ser Asp Asn  Val Glu Asp Phe Thr  Phe Thr Arg 
    1100                 1105                 1110             


Ser Ile  Glu Glu Ala Leu Asp  Asn Ser Ala Lys Val  Tyr Thr Tyr 
    1115                 1120                 1125             


Phe Pro  Thr Leu Ala Asn Lys  Val Asn Ala Gly Val  Gln Gly Gly 
    1130                 1135                 1140             


Leu Phe  Leu Met Trp Ala Asn  Asp Val Val Glu Asp  Phe Thr Thr 
    1145                 1150                 1155             


Asn Ile  Leu Arg Lys Asp Thr  Leu Asp Lys Ile Ser  Asp Val Ser 
    1160                 1165                 1170             


Ala Ile  Ile Pro Tyr Ile Gly  Pro Ala Leu Asn Ile  Ser Asn Ser 
    1175                 1180                 1185             


Val Arg  Arg Gly Asn Phe Thr  Glu Ala Phe Ala Val  Thr Gly Val 
    1190                 1195                 1200             


Thr Ile  Leu Leu Glu Ala Phe  Pro Glu Phe Thr Ile  Pro Ala Leu 
    1205                 1210                 1215             


Gly Ala  Phe Val Ile Tyr Ser  Lys Val Gln Glu Arg  Asn Glu Ile 
    1220                 1225                 1230             


Ile Lys  Thr Ile Asp Asn Cys  Leu Glu Gln Arg Ile  Lys Arg Trp 
    1235                 1240                 1245             


Lys Asp  Ser Tyr Glu Trp Met  Met Gly Thr Trp Leu  Ser Arg Ile 
    1250                 1255                 1260             


Ile Thr  Gln Phe Asn Asn Ile  Ser Tyr Gln Met Tyr  Asp Ser Leu 
    1265                 1270                 1275             


Asn Tyr  Gln Ala Gly Ala Ile  Lys Ala Lys Ile Asp  Leu Glu Tyr 
    1280                 1285                 1290             


Lys Lys  Tyr Ser Gly Ser Asp  Lys Glu Asn Ile Lys  Ser Gln Val 
    1295                 1300                 1305             


Glu Asn  Leu Lys Asn Ser Leu  Asp Val Lys Ile Ser  Glu Ala Met 
    1310                 1315                 1320             


Asn Asn  Ile Asn Lys Phe Ile  Arg Glu Cys Ser Val  Thr Tyr Leu 
    1325                 1330                 1335             


Phe Lys  Asn Met Leu Pro Lys  Val Ile Asp Glu Leu  Asn Glu Phe 
    1340                 1345                 1350             


Asp Arg  Asn Thr Lys Ala Lys  Leu Ile Asn Leu Ile  Asp Ser His 
    1355                 1360                 1365             


Asn Ile  Ile Leu Val Gly Glu  Val Asp Lys Leu Lys  Ala Lys Val 
    1370                 1375                 1380             


Asn Asn  Ser Phe Gln Asn Thr  Ile Pro Phe Asn Ile  Phe Ser Tyr 
    1385                 1390                 1395             


Thr Asn  Asn Ser Leu Leu Lys  Asp Ile Ile Asn Glu  Tyr Phe Asn 
    1400                 1405                 1410             


Asn Ile  Asn Asp Ser Lys Ile  Leu Ser Leu Gln Asn  Arg Lys Asn 
    1415                 1420                 1425             


Thr Leu  Val Asp Thr Ser Gly  Tyr Asn Ala Glu Val  Ser Glu Glu 
    1430                 1435                 1440             


Gly Asp  Val Gln Leu Asn Pro  Ile Phe Pro Phe Asp  Phe Lys Leu 
    1445                 1450                 1455             


Gly Ser  Ser Gly Glu Asp Arg  Gly Lys Val Ile Val  Thr Gln Asn 
    1460                 1465                 1470             


Glu Asn  Ile Val Tyr Asn Ser  Met Tyr Glu Ser Phe  Ser Ile Ser 
    1475                 1480                 1485             


Phe Trp  Ile Arg Ile Asn Lys  Trp Val Ser Asn Leu  Pro Gly Tyr 
    1490                 1495                 1500             


Thr Ile  Ile Asp Ser Val Lys  Asn Asn Ser Gly Trp  Ser Ile Gly 
    1505                 1510                 1515             


Ile Ile  Ser Asn Phe Leu Val  Phe Thr Leu Lys Gln  Asn Glu Asp 
    1520                 1525                 1530             


Ser Glu  Gln Ser Ile Asn Phe  Ser Tyr Asp Ile Ser  Asn Asn Ala 
    1535                 1540                 1545             


Pro Gly  Tyr Asn Lys Trp Phe  Phe Val Thr Val Thr  Asn Asn Met 
    1550                 1555                 1560             


Met Gly  Asn Met Lys Ile Tyr  Ile Asn Gly Lys Leu  Ile Asp Thr 
    1565                 1570                 1575             


Ile Lys  Val Lys Glu Leu Thr  Gly Ile Asn Phe Ser  Lys Thr Ile 
    1580                 1585                 1590             


Thr Phe  Glu Ile Asn Lys Ile  Pro Asp Thr Gly Leu  Ile Thr Ser 
    1595                 1600                 1605             


Asp Ser  Asp Asn Ile Asn Met  Trp Ile Arg Asp Phe  Tyr Ile Phe 
    1610                 1615                 1620             


Ala Lys  Glu Leu Asp Gly Lys  Asp Ile Asn Ile Leu  Phe Asn Ser 
    1625                 1630                 1635             


Leu Gln  Tyr Thr Asn Val Val  Lys Asp Tyr Trp Gly  Asn Asp Leu 
    1640                 1645                 1650             


Arg Tyr  Asn Lys Glu Tyr Tyr  Met Val Asn Ile Asp  Tyr Leu Asn 
    1655                 1660                 1665             


Arg Tyr  Met Tyr Ala Asn Ser  Arg Gln Ile Val Phe  Asn Thr Arg 
    1670                 1675                 1680             


Arg Asn  Asn Asn Asp Phe Asn  Glu Gly Tyr Lys Ile  Ile Ile Lys 
    1685                 1690                 1695             


Arg Ile  Arg Gly Asn Thr Asn  Asp Thr Arg Val Arg  Gly Gly Asp 
    1700                 1705                 1710             


Ile Leu  Tyr Phe Asp Met Thr  Ile Asn Asn Lys Ala  Tyr Asn Leu 
    1715                 1720                 1725             


Phe Met  Lys Asn Glu Thr Met  Tyr Ala Asp Asn His  Ser Thr Glu 
    1730                 1735                 1740             


Asp Ile  Tyr Ala Ile Gly Leu  Arg Glu Gln Thr Lys  Asp Ile Asn 
    1745                 1750                 1755             


Asp Asn  Ile Ile Phe Gln Ile  Gln Pro Met Asn Asn  Thr Tyr Tyr 
    1760                 1765                 1770             


Tyr Ala  Ser Gln Ile Phe Lys  Ser Asn Phe Asn Gly  Glu Asn Ile 
    1775                 1780                 1785             


Ser Gly  Ile Cys Ser Ile Gly  Thr Tyr Arg Phe Arg  Leu Gly Gly 
    1790                 1795                 1800             


Asp Trp  Tyr Arg His Asn Tyr  Leu Val Pro Thr Val  Lys Gln Gly 
    1805                 1810                 1815             


Asn Tyr  Ala Ser Leu Leu Glu  Ser Thr Ser Thr His  Trp Gly Phe 
    1820                 1825                 1830             


Val Pro  Val Ser Glu Gly Ala  Gly Tyr Pro Tyr Asp  Val Pro Asp 
    1835                 1840                 1845             


Tyr Ala  Gly Trp Glu Leu Gln  Gln Gly Ala Gly Trp  Ser His Pro 
    1850                 1855                 1860             


Gln Phe  Glu Lys Gly Ala Gly  Trp Ser His Pro Gln  Phe Glu Lys 
    1865                 1870                 1875             


Gly Ala  Gly Trp Ser His Pro  Gln Phe Glu Lys 
    1880                 1885                 


<210>  47
<211>  9851
<212>  DNA
<213>  Artificial

<220>
<223>  DNA construct for molecular construction of fusion proteins

<400>  47
gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc       60

gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc      120

acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt      180

agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg      240

ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt      300

ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta      360

taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt      420

aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt tcggggaaat      480

gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg      540

agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa      600

catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac      660

ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac      720

atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt      780

ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc      840

gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca      900

ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc      960

ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag     1020

gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa     1080

ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg     1140

gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa     1200

ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg     1260

gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt     1320

gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt     1380

caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag     1440

cattggtaac tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat     1500

ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct     1560

taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct     1620

tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca     1680

gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc     1740

agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc     1800

aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct     1860

gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag     1920

gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc     1980

tacaccgaac tgagatacct acagcgtgag cattgagaaa gcgccacgct tcccgaaggg     2040

agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag     2100

cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt     2160

gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac     2220

gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg     2280

ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc     2340

cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcctgatg     2400

cggtattttc tccttacgca tctgtgcggt atttcacacc gcagaccagc cgcgtaacct     2460

ggcaaaatcg gttacggttg agtaataaat ggatgccctg cgtaagcggg tgtgggcgga     2520

caataaagtc ttaaactgaa caaaatagat ctaaactatg acaataaagt cttaaactag     2580

acagaatagt tgtaaactga aatcagtcca gttatgctgt gaaaaagcat actggacttt     2640

tgttatggct aaagcaaact cttcattttc tgaagtgcaa attgcccgtc gtattaaaga     2700

ggggcgtggc caagggcatg gtaaagacta tattcgcggc gttgtgacaa tttaccgaac     2760

aactccgcgg ccgggaagcc gatctcggct tgaacgaatt gttaggtggc ggtacttggg     2820

tcgatatcaa agtgcatcac ttcttcccgt atgcccaact ttgtatagag agccactgcg     2880

ggatcgtcac cgtaatctgc ttgcacgtag atcacataag caccaagcgc gttggcctca     2940

tgcttgagga gattgatgag cgcggtggca atgccctgcc tccggtgctc gccggagact     3000

gcgagatcat agatatagat ctcactacgc ggctgctcaa acctgggcag aacgtaagcc     3060

gcgagagcgc caacaaccgc ttcttggtcg aaggcagcaa gcgcgatgaa tgtcttacta     3120

cggagcaagt tcccgaggta atcggagtcc ggctgatgtt gggagtaggt ggctacgtct     3180

ccgaactcac gaccgaaaag atcaagagca gcccgcatgg atttgacttg gtcagggccg     3240

agcctacatg tgcgaatgat gcccatactt gagccaccta actttgtttt agggcgactg     3300

ccctgctgcg taacatcgtt gctgctgcgt aacatcgttg ctgctccata acatcaaaca     3360

tcgacccacg gcgtaacgcg cttgctgctt ggatgcccga ggcatagact gtacaaaaaa     3420

acagtcataa caagccatga aaaccgccac tgcgccgtta ccaccgctgc gttcggtcaa     3480

ggttctggac cagttgcgtg agcgcatacg ctacttgcat tacagtttac gaaccgaaca     3540

ggcttatgtc aactgggttc gtgccttcat ccgtttccac ggtgtgcgtc acccggcaac     3600

cttgggcagc agcgaagtcg aggcatttct gtcctggctg gcgaacgagc gcaaggtttc     3660

ggtctccacg catcgtcagg cattggcggc cttgctgttc ttctacggca aggtgctgtg     3720

cacggatctg ccctggcttc aggagatcgg aagacctcgg ccgtcgcggc gcttgccggt     3780

ggtgctgacc ccggatgaag tggttcgcat cctcggtttt ctggaaggcg agcatcgttt     3840

gttcgcccag gactctagct atagttctag tggttggcta cgtatactcc ggaatattaa     3900

tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt     3960

ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca     4020

ccatcgggcg cggatctcgg tccgttcgaa ccagaactct ggaagcttaa ctcctaaaaa     4080

accgccacca tgaaattctt agtcaacgtt gcccttgttt ttatggtcgt atacatttct     4140

tacatctatg cggccggaca ccaccaccac caccaccacc accaccacca cgacgtcggc     4200

tgggagctgc aaggcgccgg cggtgcggcc gctcaggttc agttggtgga atcaggcggc     4260

ggctcagttc aagcaggcgg ttcactcagg ctctcgtgtg cggcaagcgg tatcgactcg     4320

tccagctact gcatgggatg gttcaggcaa aggccaggaa aggagaggga aggtgttgct     4380

cgtatcaacg gactgggtgg cgttaagaca gcatacgcgg acagtgtgaa agataggttc     4440

acaatttcga gagacaacgc agagaacacg gtctacttgc agatgaactc tctgaagccc     4500

gaagatacgg cgatctacta ctgcgctgcc aaattctcac ccggatactg tggaggtagc     4560

tggtctaact tcggttactg gggtcaaggc acccaagtga ctgtctcttc aggcggaggt     4620

gcggccgctg gctcaggagg tggcagtcag gtgcagctgc aggagtcggg aggtggctcc     4680

gtccaagcag gaggtagcct gcgcctctct tgcgcagcgt caggtatcga cagttcgtcc     4740

tactgtatgg gctggttcag gcagcgtcct ggcaaggaga gggaaggagt ggcacgtatc     4800

aacggtctcg gcggagtcaa gacagcttac gccgactccg ttaaagatag gttcaccatt     4860

agccgcgaca acgctgagaa cactgtctac ctccaaatga acagtttgaa gccggaagat     4920

actgccattt actactgtgc tgccaaattc tcaccgggct actgtggagg aagctggtct     4980

aacttcggct actggggaca aggaactcaa gtcaccgttg gggccggcca gggtgctggt     5040

gctggaccga tcaccatcaa caacttcaat tactcggatc cggtggataa caagaacatc     5100

ctctacttgg acacacactt gaacacgctg gctaacgagc ctgaaaaagc tttcaggatc     5160

accggcaaca tttgggtcat tccggatagg ttcagcagaa actctaaccc taacttgaac     5220

aaacctccca gagtgacctc acctaagagt ggatactacg accccaacta cctctcgact     5280

gactccgata aagacccctt cctgaaggag atcattaaac tcttcaagcg catcaactct     5340

cgtgaaattg gcgaggaatt gatctaccgc ctgagtacag acatcccatt cccgggtaac     5400

aacaacaccc caatcaacac tttcgatttc gatgtcgatt tcaactcagt ggatgtcaaa     5460

accaggcagg gaaacaactg ggtgaagact ggtagcatca acccatctgt catcattact     5520

ggcccgagag agaacatcat tgaccctgaa acctccactt tcaagctgac aaacaacacg     5580

ttcgctgctc aggaaggctt cggagcgttg agcatcattt ctatctcacc tcgcttcatg     5640

ctgacatact ctaacgctac gaacgacgtg ggagagggcc gtttcagtaa gtctgaattc     5700

tgcatggacc ctattctgat cctcatgcac gctctcaacg gcgccatgca caacttgtac     5760

ggaattgcta tccccaacga ccagaccatt tccagcgtga ctagcaacat cttctactct     5820

caatacaacg tcaagctgga gtacgcagaa atctacgctt tcggtggccc aaccattgac     5880

ttgatcccga aatcagctcg taagtatttc gaagaaaaag cgctggatta ttacaggtcg     5940

attgctaaga gactcaactc catcaccact gctaacccct cttcattcaa caagtacatt     6000

ggagaataca agcagaaact gatccgcaag taccgtttcg tggtcgagag ttcgggtgaa     6060

gttactgtga accgcaacaa gttcgtcgag ctgtacaacg aattgacaca aatcttcacg     6120

gagttcaact acgccaaaat ttacaacgtg caaaaccgta agatcgcgct ctctaacgtc     6180

tacaccccgg ttaccgctaa catcttggac gataacgtct acgacattca gaacggtttc     6240

aacatcccaa agtcgaacct caacgttttg ttcatgggtc aaaacttgtc ccgcaacccc     6300

gccctgcgta aggtgaaccc agagaacatg ttgtacctgt tcaccaaatt ctgccacaag     6360

gccatcgacg gtcagtctct agaccaagga ggatgggaac tccagcaagg tggccagggt     6420

ggaggtgctg gcaccctgga ctgtcgcgaa ctgctcgtta agaacactga tctcccattc     6480

attggcgaca tctctgatgt gaaaacagac attttcctgc gtaaggatat caacgaggaa     6540

acggaggtca tctactaccc tgacaacgtc tcggttgatc aggttatctt gtcaaagaac     6600

accagtgaac atggccaact ggacttgctg tacccctcaa ttgattccga gagcgaaatc     6660

ctgccaggag agaaccaggt tttctacgac aacaggacac aaaacgtgga ttacctcaac     6720

agctactact acctggagtc gcagaagctc tccgacaacg tcgaagattt cacatttacg     6780

agatcaatcg aggaggcttt ggacaacagt gccaaagtct acacctactt ccctactctg     6840

gcaaacaagg tgaacgcggg tgtccaaggc ggactcttct tgatgtgggc taacgacgtt     6900

gtggaagatt tcacaacgaa catcttgcgc aaagacaccc tggataagat cagcgatgtc     6960

tctgccatca ttccatacat tggcccggca ctgaacatct ctaactcagt tcgccgtggc     7020

aacttcactg aggcattcgc ggtcacagga gttacgatcc tcttggaggc tttcccggag     7080

ttcacaatcc ccgcactggg cgcgttcgtt atctactcca aagtgcagga gcgcaacgaa     7140

atcattaaga ctatcgacaa ctgcctggag caaaggatca aaagatggaa ggattcgtac     7200

gaatggatga tgggtacctg gctctcccgt atcattacgc agttcaacaa catcagctac     7260

caaatgtacg actctctcaa ctaccaggct ggtgccatca aggccaaaat tgacttggag     7320

tacaagaaat acagtggctc ggataaagag aacatcaaga gtcaagtcga aaacctgaaa     7380

aactcactcg acgttaagat cagtgaggca atgaacaaca tcaacaagtt cattcgcgaa     7440

tgttccgtta cctacctctt caaaaacatg ttgccaaagg tcatcgacga gctgaacgaa     7500

tttgatcgta acactaaggc gaaactgatt aacctcatcg actcacacaa catcattttg     7560

gtgggcgaag tcgataagct gaaagccaag gtgaacaaca gtttccagaa cacaatccct     7620

ttcaacattt tctcatacac gaacaacagt ctgctcaagg acatcattaa cgagtacttc     7680

aacaacatta acgatagcaa aatcctgtca ctgcagaacc gtaagaacac actggtcgat     7740

actagtggat acaacgccga agtctctgag gaaggtgacg tgcagctgaa ccctatcttc     7800

cccttcgact tcaaattggg ctccagcgga gaggataggg gcaaggtcat cgtcacccag     7860

aacgagaaca tcgtctacaa ctcaatgtac gaatccttca gcatctcttt ctggatcagg     7920

attaacaagt gggtgagcaa cctgcccggt tacacaatca ttgactctgt caagaacaac     7980

tcaggttgga gtatcggcat catttctaac ttcttggtct tcaccctgaa gcagaacgag     8040

gactcggaac aatccattaa cttctcatac gatatcagta acaacgctcc aggttacaac     8100

aagtggttct tcgttaccgt gactaacaac atgatgggta acatgaaaat ttacatcaac     8160

ggcaagctca ttgacaccat caaagtgaag gagttgactg gtattaactt ctccaaaaca     8220

atcacgtttg aaattaacaa gatccctgac accggcctga tcacttcaga cagtgataac     8280

atcaacatgt ggattaggga tttctacatc ttcgccaagg agctcgacgg aaaggatatt     8340

aacatcctct tcaacagctt gcagtacacc aacgtcgtta aagactactg gggtaacgat     8400

ttgagataca acaaggagta ctacatggtc aacatcgact acctgaacag gtacatgtac     8460

gctaactccc gccaaatcgt gttcaacacc aggagaaaca acaacgactt caacgagggt     8520

tacaaaatca ttatcaagcg catccgtggc aacaccaacg atactagggt gagaggtggc     8580

gacattctgt acttcgatat gactatcaac aacaaagcct acaacttgtt catgaaaaac     8640

gagacaatgt acgccgacaa ccatagcacg gaggatattt acgcaatcgg actgagggaa     8700

cagacaaagg acatcaacga taacattatc ttccagatcc aacctatgaa caacacgtac     8760

tactacgctt cgcaaatctt caagtccaac ttcaacggag aaaacatttc gggtatctgt     8820

tccattggca cataccgctt ccgtctgggt ggtgactggt atcgtcacaa ctacctcgtt     8880

cccaccgtga agcagggtaa ctacgcttct ttgctggagt cgacttccac gcactgggga     8940

ttcgttcctg tgtcagaggg cgctggctac ccttacgatg ttcccgacta cgctggttgg     9000

gaactccagc aaggtgcagg atggtcccac cctcaattcg agaagggtgc cggatggagt     9060

cacccacagt tcgagaaagg cgctggatgg agtcacccac agttcgagaa ataattagtt     9120

gatgcatagt taattagata gctcgaggca tgcggtacca agattggatc tagatgcata     9180

gttaattaga tagctcgagg catgcggtac caagcttgtc gagaagtact agaggatcat     9240

aatcagccat accacatttg tagaggtttt acttgcttta aaaaacctcc cacacctccc     9300

cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt aacttgttta ttgcagctta     9360

taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact     9420

gcattctagt tgtggtttgt ccaaactcat caatgtatct tatcatgtct ggatctgatc     9480

actgcttgag cctaggagat ccgaaccaga taagtgaaat ctagttccaa actattttgt     9540

catttttaat tttcgtatta gcttacgacg ctacacccag ttcccatcta ttttgtcact     9600

cttccctaaa taatccttaa aaactccatt tccacccctc ccagttccca actattttgt     9660

ccgcccacag cggggcattt ttcttcctgt tatgttttta atcaaacatc ctgccaactc     9720

catgtgacaa accgtcatct tcggctactt tttctctgtc acagaatgaa aatttttctg     9780

tcatctcttc gttattaatg tttgtaattg actgaatatc aacgcttatt tgcagcctga     9840

atggcgaatg g                                                          9851


<210>  48
<211>  1674
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein construct

<400>  48

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ala Gly His His His His His His His His His 
            20                  25                  30          


His His Asp Val Gly Trp Glu Leu Gln Gly Ala Gly Gly Ala Ala Ala 
        35                  40                  45              


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
    50                  55                  60                  


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Ser Ser Ser Tyr 
65                  70                  75                  80  


Cys Met Gly Trp Phe Arg Gln Arg Pro Gly Lys Glu Arg Glu Gly Val 
                85                  90                  95      


Ala Arg Ile Asn Gly Leu Gly Gly Val Lys Thr Ala Tyr Ala Asp Ser 
            100                 105                 110         


Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Val 
        115                 120                 125             


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr 
    130                 135                 140                 


Cys Ala Ala Lys Phe Ser Pro Gly Tyr Cys Gly Gly Ser Trp Ser Asn 
145                 150                 155                 160 


Phe Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
                165                 170                 175     


Gly Ala Ala Ala Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
            180                 185                 190         


Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys 
        195                 200                 205             


Ala Ala Ser Gly Ile Asp Ser Ser Ser Tyr Cys Met Gly Trp Phe Arg 
    210                 215                 220                 


Gln Arg Pro Gly Lys Glu Arg Glu Gly Val Ala Arg Ile Asn Gly Leu 
225                 230                 235                 240 


Gly Gly Val Lys Thr Ala Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
                245                 250                 255     


Ile Ser Arg Asp Asn Ala Glu Asn Thr Val Tyr Leu Gln Met Asn Ser 
            260                 265                 270         


Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Lys Phe Ser 
        275                 280                 285             


Pro Gly Tyr Cys Gly Gly Ser Trp Ser Asn Phe Gly Tyr Trp Gly Gln 
    290                 295                 300                 


Gly Thr Gln Val Thr Val Gly Ala Gly Gln Gly Ala Gly Ala Gly Pro 
305                 310                 315                 320 


Ile Thr Ile Asn Asn Phe Asn Tyr Ser Asp Pro Val Asp Asn Lys Asn 
                325                 330                 335     


Ile Leu Tyr Leu Asp Thr His Leu Asn Thr Leu Ala Asn Glu Pro Glu 
            340                 345                 350         


Lys Ala Phe Arg Ile Thr Gly Asn Ile Trp Val Ile Pro Asp Arg Phe 
        355                 360                 365             


Ser Arg Asn Ser Asn Pro Asn Leu Asn Lys Pro Pro Arg Val Thr Ser 
    370                 375                 380                 


Pro Lys Ser Gly Tyr Tyr Asp Pro Asn Tyr Leu Ser Thr Asp Ser Asp 
385                 390                 395                 400 


Lys Asp Pro Phe Leu Lys Glu Ile Ile Lys Leu Phe Lys Arg Ile Asn 
                405                 410                 415     


Ser Arg Glu Ile Gly Glu Glu Leu Ile Tyr Arg Leu Ser Thr Asp Ile 
            420                 425                 430         


Pro Phe Pro Gly Asn Asn Asn Thr Pro Ile Asn Thr Phe Asp Phe Asp 
        435                 440                 445             


Val Asp Phe Asn Ser Val Asp Val Lys Thr Arg Gln Gly Asn Asn Trp 
    450                 455                 460                 


Val Lys Thr Gly Ser Ile Asn Pro Ser Val Ile Ile Thr Gly Pro Arg 
465                 470                 475                 480 


Glu Asn Ile Ile Asp Pro Glu Thr Ser Thr Phe Lys Leu Thr Asn Asn 
                485                 490                 495     


Thr Phe Ala Ala Gln Glu Gly Phe Gly Ala Leu Ser Ile Ile Ser Ile 
            500                 505                 510         


Ser Pro Arg Phe Met Leu Thr Tyr Ser Asn Ala Thr Asn Asp Val Gly 
        515                 520                 525             


Glu Gly Arg Phe Ser Lys Ser Glu Phe Cys Met Asp Pro Ile Leu Ile 
    530                 535                 540                 


Leu Met His Ala Leu Asn Gly Ala Met His Asn Leu Tyr Gly Ile Ala 
545                 550                 555                 560 


Ile Pro Asn Asp Gln Thr Ile Ser Ser Val Thr Ser Asn Ile Phe Tyr 
                565                 570                 575     


Ser Gln Tyr Asn Val Lys Leu Glu Tyr Ala Glu Ile Tyr Ala Phe Gly 
            580                 585                 590         


Gly Pro Thr Ile Asp Leu Ile Pro Lys Ser Ala Arg Lys Tyr Phe Glu 
        595                 600                 605             


Glu Lys Ala Leu Asp Tyr Tyr Arg Ser Ile Ala Lys Arg Leu Asn Ser 
    610                 615                 620                 


Ile Thr Thr Ala Asn Pro Ser Ser Phe Asn Lys Tyr Ile Gly Glu Tyr 
625                 630                 635                 640 


Lys Gln Lys Leu Ile Arg Lys Tyr Arg Phe Val Val Glu Ser Ser Gly 
                645                 650                 655     


Glu Val Thr Val Asn Arg Asn Lys Phe Val Glu Leu Tyr Asn Glu Leu 
            660                 665                 670         


Thr Gln Ile Phe Thr Glu Phe Asn Tyr Ala Lys Ile Tyr Asn Val Gln 
        675                 680                 685             


Asn Arg Lys Ile Ala Leu Ser Asn Val Tyr Thr Pro Val Thr Ala Asn 
    690                 695                 700                 


Ile Leu Asp Asp Asn Val Tyr Asp Ile Gln Asn Gly Phe Asn Ile Pro 
705                 710                 715                 720 


Lys Ser Asn Leu Asn Val Leu Phe Met Gly Gln Asn Leu Ser Arg Asn 
                725                 730                 735     


Pro Ala Leu Arg Lys Val Asn Pro Glu Asn Met Leu Tyr Leu Phe Thr 
            740                 745                 750         


Lys Phe Cys His Lys Ala Ile Asp Gly Gln Ser Leu Asp Gln Gly Gly 
        755                 760                 765             


Trp Glu Leu Gln Gln Gly Gly Gln Gly Gly Gly Ala Gly Thr Leu Asp 
    770                 775                 780                 


Cys Arg Glu Leu Leu Val Lys Asn Thr Asp Leu Pro Phe Ile Gly Asp 
785                 790                 795                 800 


Ile Ser Asp Val Lys Thr Asp Ile Phe Leu Arg Lys Asp Ile Asn Glu 
                805                 810                 815     


Glu Thr Glu Val Ile Tyr Tyr Pro Asp Asn Val Ser Val Asp Gln Val 
            820                 825                 830         


Ile Leu Ser Lys Asn Thr Ser Glu His Gly Gln Leu Asp Leu Leu Tyr 
        835                 840                 845             


Pro Ser Ile Asp Ser Glu Ser Glu Ile Leu Pro Gly Glu Asn Gln Val 
    850                 855                 860                 


Phe Tyr Asp Asn Arg Thr Gln Asn Val Asp Tyr Leu Asn Ser Tyr Tyr 
865                 870                 875                 880 


Tyr Leu Glu Ser Gln Lys Leu Ser Asp Asn Val Glu Asp Phe Thr Phe 
                885                 890                 895     


Thr Arg Ser Ile Glu Glu Ala Leu Asp Asn Ser Ala Lys Val Tyr Thr 
            900                 905                 910         


Tyr Phe Pro Thr Leu Ala Asn Lys Val Asn Ala Gly Val Gln Gly Gly 
        915                 920                 925             


Leu Phe Leu Met Trp Ala Asn Asp Val Val Glu Asp Phe Thr Thr Asn 
    930                 935                 940                 


Ile Leu Arg Lys Asp Thr Leu Asp Lys Ile Ser Asp Val Ser Ala Ile 
945                 950                 955                 960 


Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile Ser Asn Ser Val Arg Arg 
                965                 970                 975     


Gly Asn Phe Thr Glu Ala Phe Ala Val Thr Gly Val Thr Ile Leu Leu 
            980                 985                 990         


Glu Ala Phe Pro Glu Phe Thr Ile  Pro Ala Leu Gly Ala  Phe Val Ile 
        995                 1000                 1005             


Tyr Ser  Lys Val Gln Glu Arg  Asn Glu Ile Ile Lys  Thr Ile Asp 
    1010                 1015                 1020             


Asn Cys  Leu Glu Gln Arg Ile  Lys Arg Trp Lys Asp  Ser Tyr Glu 
    1025                 1030                 1035             


Trp Met  Met Gly Thr Trp Leu  Ser Arg Ile Ile Thr  Gln Phe Asn 
    1040                 1045                 1050             


Asn Ile  Ser Tyr Gln Met Tyr  Asp Ser Leu Asn Tyr  Gln Ala Gly 
    1055                 1060                 1065             


Ala Ile  Lys Ala Lys Ile Asp  Leu Glu Tyr Lys Lys  Tyr Ser Gly 
    1070                 1075                 1080             


Ser Asp  Lys Glu Asn Ile Lys  Ser Gln Val Glu Asn  Leu Lys Asn 
    1085                 1090                 1095             


Ser Leu  Asp Val Lys Ile Ser  Glu Ala Met Asn Asn  Ile Asn Lys 
    1100                 1105                 1110             


Phe Ile  Arg Glu Cys Ser Val  Thr Tyr Leu Phe Lys  Asn Met Leu 
    1115                 1120                 1125             


Pro Lys  Val Ile Asp Glu Leu  Asn Glu Phe Asp Arg  Asn Thr Lys 
    1130                 1135                 1140             


Ala Lys  Leu Ile Asn Leu Ile  Asp Ser His Asn Ile  Ile Leu Val 
    1145                 1150                 1155             


Gly Glu  Val Asp Lys Leu Lys  Ala Lys Val Asn Asn  Ser Phe Gln 
    1160                 1165                 1170             


Asn Thr  Ile Pro Phe Asn Ile  Phe Ser Tyr Thr Asn  Asn Ser Leu 
    1175                 1180                 1185             


Leu Lys  Asp Ile Ile Asn Glu  Tyr Phe Asn Asn Ile  Asn Asp Ser 
    1190                 1195                 1200             


Lys Ile  Leu Ser Leu Gln Asn  Arg Lys Asn Thr Leu  Val Asp Thr 
    1205                 1210                 1215             


Ser Gly  Tyr Asn Ala Glu Val  Ser Glu Glu Gly Asp  Val Gln Leu 
    1220                 1225                 1230             


Asn Pro  Ile Phe Pro Phe Asp  Phe Lys Leu Gly Ser  Ser Gly Glu 
    1235                 1240                 1245             


Asp Arg  Gly Lys Val Ile Val  Thr Gln Asn Glu Asn  Ile Val Tyr 
    1250                 1255                 1260             


Asn Ser  Met Tyr Glu Ser Phe  Ser Ile Ser Phe Trp  Ile Arg Ile 
    1265                 1270                 1275             


Asn Lys  Trp Val Ser Asn Leu  Pro Gly Tyr Thr Ile  Ile Asp Ser 
    1280                 1285                 1290             


Val Lys  Asn Asn Ser Gly Trp  Ser Ile Gly Ile Ile  Ser Asn Phe 
    1295                 1300                 1305             


Leu Val  Phe Thr Leu Lys Gln  Asn Glu Asp Ser Glu  Gln Ser Ile 
    1310                 1315                 1320             


Asn Phe  Ser Tyr Asp Ile Ser  Asn Asn Ala Pro Gly  Tyr Asn Lys 
    1325                 1330                 1335             


Trp Phe  Phe Val Thr Val Thr  Asn Asn Met Met Gly  Asn Met Lys 
    1340                 1345                 1350             


Ile Tyr  Ile Asn Gly Lys Leu  Ile Asp Thr Ile Lys  Val Lys Glu 
    1355                 1360                 1365             


Leu Thr  Gly Ile Asn Phe Ser  Lys Thr Ile Thr Phe  Glu Ile Asn 
    1370                 1375                 1380             


Lys Ile  Pro Asp Thr Gly Leu  Ile Thr Ser Asp Ser  Asp Asn Ile 
    1385                 1390                 1395             


Asn Met  Trp Ile Arg Asp Phe  Tyr Ile Phe Ala Lys  Glu Leu Asp 
    1400                 1405                 1410             


Gly Lys  Asp Ile Asn Ile Leu  Phe Asn Ser Leu Gln  Tyr Thr Asn 
    1415                 1420                 1425             


Val Val  Lys Asp Tyr Trp Gly  Asn Asp Leu Arg Tyr  Asn Lys Glu 
    1430                 1435                 1440             


Tyr Tyr  Met Val Asn Ile Asp  Tyr Leu Asn Arg Tyr  Met Tyr Ala 
    1445                 1450                 1455             


Asn Ser  Arg Gln Ile Val Phe  Asn Thr Arg Arg Asn  Asn Asn Asp 
    1460                 1465                 1470             


Phe Asn  Glu Gly Tyr Lys Ile  Ile Ile Lys Arg Ile  Arg Gly Asn 
    1475                 1480                 1485             


Thr Asn  Asp Thr Arg Val Arg  Gly Gly Asp Ile Leu  Tyr Phe Asp 
    1490                 1495                 1500             


Met Thr  Ile Asn Asn Lys Ala  Tyr Asn Leu Phe Met  Lys Asn Glu 
    1505                 1510                 1515             


Thr Met  Tyr Ala Asp Asn His  Ser Thr Glu Asp Ile  Tyr Ala Ile 
    1520                 1525                 1530             


Gly Leu  Arg Glu Gln Thr Lys  Asp Ile Asn Asp Asn  Ile Ile Phe 
    1535                 1540                 1545             


Gln Ile  Gln Pro Met Asn Asn  Thr Tyr Tyr Tyr Ala  Ser Gln Ile 
    1550                 1555                 1560             


Phe Lys  Ser Asn Phe Asn Gly  Glu Asn Ile Ser Gly  Ile Cys Ser 
    1565                 1570                 1575             


Ile Gly  Thr Tyr Arg Phe Arg  Leu Gly Gly Asp Trp  Tyr Arg His 
    1580                 1585                 1590             


Asn Tyr  Leu Val Pro Thr Val  Lys Gln Gly Asn Tyr  Ala Ser Leu 
    1595                 1600                 1605             


Leu Glu  Ser Thr Ser Thr His  Trp Gly Phe Val Pro  Val Ser Glu 
    1610                 1615                 1620             


Gly Ala  Gly Tyr Pro Tyr Asp  Val Pro Asp Tyr Ala  Gly Trp Glu 
    1625                 1630                 1635             


Leu Gln  Gln Gly Ala Gly Trp  Ser His Pro Gln Phe  Glu Lys Gly 
    1640                 1645                 1650             


Ala Gly  Trp Ser His Pro Gln  Phe Glu Lys Gly Ala  Gly Trp Ser 
    1655                 1660                 1665             


His Pro  Gln Phe Glu Lys 
    1670                 


<210>  49
<211>  10457
<212>  DNA
<213>  Artificial

<220>
<223>  DNA construct for molecular construction of fusion proteins

<400>  49
gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc       60

gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc      120

acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt      180

agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg      240

ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt      300

ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta      360

taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt      420

aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt tcggggaaat      480

gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg      540

agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa      600

catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac      660

ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac      720

atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt      780

ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc      840

gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca      900

ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc      960

ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag     1020

gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa     1080

ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg     1140

gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa     1200

ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg     1260

gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt     1320

gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt     1380

caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag     1440

cattggtaac tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat     1500

ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct     1560

taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct     1620

tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca     1680

gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc     1740

agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc     1800

aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct     1860

gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag     1920

gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc     1980

tacaccgaac tgagatacct acagcgtgag cattgagaaa gcgccacgct tcccgaaggg     2040

agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag     2100

cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt     2160

gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac     2220

gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg     2280

ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc     2340

cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcctgatg     2400

cggtattttc tccttacgca tctgtgcggt atttcacacc gcagaccagc cgcgtaacct     2460

ggcaaaatcg gttacggttg agtaataaat ggatgccctg cgtaagcggg tgtgggcgga     2520

caataaagtc ttaaactgaa caaaatagat ctaaactatg acaataaagt cttaaactag     2580

acagaatagt tgtaaactga aatcagtcca gttatgctgt gaaaaagcat actggacttt     2640

tgttatggct aaagcaaact cttcattttc tgaagtgcaa attgcccgtc gtattaaaga     2700

ggggcgtggc caagggcatg gtaaagacta tattcgcggc gttgtgacaa tttaccgaac     2760

aactccgcgg ccgggaagcc gatctcggct tgaacgaatt gttaggtggc ggtacttggg     2820

tcgatatcaa agtgcatcac ttcttcccgt atgcccaact ttgtatagag agccactgcg     2880

ggatcgtcac cgtaatctgc ttgcacgtag atcacataag caccaagcgc gttggcctca     2940

tgcttgagga gattgatgag cgcggtggca atgccctgcc tccggtgctc gccggagact     3000

gcgagatcat agatatagat ctcactacgc ggctgctcaa acctgggcag aacgtaagcc     3060

gcgagagcgc caacaaccgc ttcttggtcg aaggcagcaa gcgcgatgaa tgtcttacta     3120

cggagcaagt tcccgaggta atcggagtcc ggctgatgtt gggagtaggt ggctacgtct     3180

ccgaactcac gaccgaaaag atcaagagca gcccgcatgg atttgacttg gtcagggccg     3240

agcctacatg tgcgaatgat gcccatactt gagccaccta actttgtttt agggcgactg     3300

ccctgctgcg taacatcgtt gctgctgcgt aacatcgttg ctgctccata acatcaaaca     3360

tcgacccacg gcgtaacgcg cttgctgctt ggatgcccga ggcatagact gtacaaaaaa     3420

acagtcataa caagccatga aaaccgccac tgcgccgtta ccaccgctgc gttcggtcaa     3480

ggttctggac cagttgcgtg agcgcatacg ctacttgcat tacagtttac gaaccgaaca     3540

ggcttatgtc aactgggttc gtgccttcat ccgtttccac ggtgtgcgtc acccggcaac     3600

cttgggcagc agcgaagtcg aggcatttct gtcctggctg gcgaacgagc gcaaggtttc     3660

ggtctccacg catcgtcagg cattggcggc cttgctgttc ttctacggca aggtgctgtg     3720

cacggatctg ccctggcttc aggagatcgg aagacctcgg ccgtcgcggc gcttgccggt     3780

ggtgctgacc ccggatgaag tggttcgcat cctcggtttt ctggaaggcg agcatcgttt     3840

gttcgcccag gactctagct atagttctag tggttggcta cgtatactcc ggaatattaa     3900

tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt     3960

ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca     4020

ccatcgggcg cggatctcgg tccgttcgaa ccagaactct ggaagcttaa ctcctaaaaa     4080

accgccacca tgaaattctt agtcaacgtt gcccttgttt ttatggtcgt atacatttct     4140

tacatctatg cggccggaca ccaccaccac caccaccacc accaccacca cgacgtcggc     4200

tgggagctgc aacgtcgtcc cctgaactgc atcgtggctg tgtcccagaa catgggtatc     4260

ggcaagaacg gcgacctgcc ctggcctcct ctgcgtaacg agttcaagta cttccagcgt     4320

atgaccacca cctcctccgt cgagggcaag cagaacctgg tcatcatggg tcgcaagacc     4380

tggttctcca tccccgagaa gaaccgtctg ctgaaggacc gtatcaacat cgtgctgtcc     4440

cgcgagctga aggaaccccc tcgtggtgct cacttcctgg ctaagtccct ggacgacgct     4500

ctgcgtctga tcgagcagcc tgagctggct tccaaggtgg acatggtctg gatcgtgggc     4560

ggttcctccg tgtaccaaga ggctatgaac cagcccggtc acttgcgtct gttcgtgacc     4620

cgtatcatgc aagagttcga gtccgacacc ttcttccccg aaatcgacct gggcaagtac     4680

aagctgctgc ccgagtaccc cggtgtcctg tccgaggtgc aagaggaaaa gggtatcaag     4740

tacaagttcg aggtgtacga gaagaaggac ggcgcttccg gtttcgctaa cgagctcggt     4800

cctcgtctga tgggaaaggg cgccggcggt gcggccgctc aggttcagtt ggtggaatca     4860

ggcggcggct cagttcaagc aggcggttca ctcaggctct cgtgtgcggc aagcggtatc     4920

gactcgtcca gctactgcat gggatggttc aggcaaaggc caggaaagga gagggaaggt     4980

gttgctcgta tcaacggact gggtggcgtt aagacagcat acgcggacag tgtgaaagat     5040

aggttcacaa tttcgagaga caacgcagag aacacggtct acttgcagat gaactctctg     5100

aagcccgaag atacggcgat ctactactgc gctgccaaat tctcacccgg atactgtgga     5160

ggtagctggt ctaacttcgg ttactggggt caaggcaccc aagtgactgt ctcttcaggc     5220

ggaggtgcgg ccgctggctc aggaggtggc agtcaggtgc agctgcagga gtcgggaggt     5280

ggctccgtcc aagcaggagg tagcctgcgc ctctcttgcg cagcgtcagg tatcgacagt     5340

tcgtcctact gtatgggctg gttcaggcag cgtcctggca aggagaggga aggagtggca     5400

cgtatcaacg gtctcggcgg agtcaagaca gcttacgccg actccgttaa agataggttc     5460

accattagcc gcgacaacgc tgagaacact gtctacctcc aaatgaacag tttgaagccg     5520

gaagatactg ccatttacta ctgtgctgcc aaattctcac cgggctactg tggaggaagc     5580

tggtctaact tcggctactg gggacaagga actcaagtca ccgttggggc cggccagggt     5640

gctggtgctg gaccgatcac catcaacaac ttcaattact cggatccggt ggataacaag     5700

aacatcctct acttggacac acacttgaac acgctggcta acgagcctga aaaagctttc     5760

aggatcaccg gcaacatttg ggtcattccg gataggttca gcagaaactc taaccctaac     5820

ttgaacaaac ctcccagagt gacctcacct aagagtggat actacgaccc caactacctc     5880

tcgactgact ccgataaaga ccccttcctg aaggagatca ttaaactctt caagcgcatc     5940

aactctcgtg aaattggcga ggaattgatc taccgcctga gtacagacat cccattcccg     6000

ggtaacaaca acaccccaat caacactttc gatttcgatg tcgatttcaa ctcagtggat     6060

gtcaaaacca ggcagggaaa caactgggtg aagactggta gcatcaaccc atctgtcatc     6120

attactggcc cgagagagaa catcattgac cctgaaacct ccactttcaa gctgacaaac     6180

aacacgttcg ctgctcagga aggcttcgga gcgttgagca tcatttctat ctcacctcgc     6240

ttcatgctga catactctaa cgctacgaac gacgtgggag agggccgttt cagtaagtct     6300

gaattctgca tggaccctat tctgatcctc atgcacgctc tcaacggcgc catgcacaac     6360

ttgtacggaa ttgctatccc caacgaccag accatttcca gcgtgactag caacatcttc     6420

tactctcaat acaacgtcaa gctggagtac gcagaaatct acgctttcgg tggcccaacc     6480

attgacttga tcccgaaatc agctcgtaag tatttcgaag aaaaagcgct ggattattac     6540

aggtcgattg ctaagagact caactccatc accactgcta acccctcttc attcaacaag     6600

tacattggag aatacaagca gaaactgatc cgcaagtacc gtttcgtggt cgagagttcg     6660

ggtgaagtta ctgtgaaccg caacaagttc gtcgagctgt acaacgaatt gacacaaatc     6720

ttcacggagt tcaactacgc caaaatttac aacgtgcaaa accgtaagat cgcgctctct     6780

aacgtctaca ccccggttac cgctaacatc ttggacgata acgtctacga cattcagaac     6840

ggtttcaaca tcccaaagtc gaacctcaac gttttgttca tgggtcaaaa cttgtcccgc     6900

aaccccgccc tgcgtaaggt gaacccagag aacatgttgt acctgttcac caaattctgc     6960

cacaaggcca tcgacggtca gtctctagac caaggaggat gggaactcca gcaaggtggc     7020

cagggtggag gtgctggcac cctggactgt cgcgaactgc tcgttaagaa cactgatctc     7080

ccattcattg gcgacatctc tgatgtgaaa acagacattt tcctgcgtaa ggatatcaac     7140

gaggaaacgg aggtcatcta ctaccctgac aacgtctcgg ttgatcaggt tatcttgtca     7200

aagaacacca gtgaacatgg ccaactggac ttgctgtacc cctcaattga ttccgagagc     7260

gaaatcctgc caggagagaa ccaggttttc tacgacaaca ggacacaaaa cgtggattac     7320

ctcaacagct actactacct ggagtcgcag aagctctccg acaacgtcga agatttcaca     7380

tttacgagat caatcgagga ggctttggac aacagtgcca aagtctacac ctacttccct     7440

actctggcaa acaaggtgaa cgcgggtgtc caaggcggac tcttcttgat gtgggctaac     7500

gacgttgtgg aagatttcac aacgaacatc ttgcgcaaag acaccctgga taagatcagc     7560

gatgtctctg ccatcattcc atacattggc ccggcactga acatctctaa ctcagttcgc     7620

cgtggcaact tcactgaggc attcgcggtc acaggagtta cgatcctctt ggaggctttc     7680

ccggagttca caatccccgc actgggcgcg ttcgttatct actccaaagt gcaggagcgc     7740

aacgaaatca ttaagactat cgacaactgc ctggagcaaa ggatcaaaag atggaaggat     7800

tcgtacgaat ggatgatggg tacctggctc tcccgtatca ttacgcagtt caacaacatc     7860

agctaccaaa tgtacgactc tctcaactac caggctggtg ccatcaaggc caaaattgac     7920

ttggagtaca agaaatacag tggctcggat aaagagaaca tcaagagtca agtcgaaaac     7980

ctgaaaaact cactcgacgt taagatcagt gaggcaatga acaacatcaa caagttcatt     8040

cgcgaatgtt ccgttaccta cctcttcaaa aacatgttgc caaaggtcat cgacgagctg     8100

aacgaatttg atcgtaacac taaggcgaaa ctgattaacc tcatcgactc acacaacatc     8160

attttggtgg gcgaagtcga taagctgaaa gccaaggtga acaacagttt ccagaacaca     8220

atccctttca acattttctc atacacgaac aacagtctgc tcaaggacat cattaacgag     8280

tacttcaaca acattaacga tagcaaaatc ctgtcactgc agaaccgtaa gaacacactg     8340

gtcgatacta gtggatacaa cgccgaagtc tctgaggaag gtgacgtgca gctgaaccct     8400

atcttcccct tcgacttcaa attgggctcc agcggagagg ataggggcaa ggtcatcgtc     8460

acccagaacg agaacatcgt ctacaactca atgtacgaat ccttcagcat ctctttctgg     8520

atcaggatta acaagtgggt gagcaacctg cccggttaca caatcattga ctctgtcaag     8580

aacaactcag gttggagtat cggcatcatt tctaacttct tggtcttcac cctgaagcag     8640

aacgaggact cggaacaatc cattaacttc tcatacgata tcagtaacaa cgctccaggt     8700

tacaacaagt ggttcttcgt taccgtgact aacaacatga tgggtaacat gaaaatttac     8760

atcaacggca agctcattga caccatcaaa gtgaaggagt tgactggtat taacttctcc     8820

aaaacaatca cgtttgaaat taacaagatc cctgacaccg gcctgatcac ttcagacagt     8880

gataacatca acatgtggat tagggatttc tacatcttcg ccaaggagct cgacggaaag     8940

gatattaaca tcctcttcaa cagcttgcag tacaccaacg tcgttaaaga ctactggggt     9000

aacgatttga gatacaacaa ggagtactac atggtcaaca tcgactacct gaacaggtac     9060

atgtacgcta actcccgcca aatcgtgttc aacaccagga gaaacaacaa cgacttcaac     9120

gagggttaca aaatcattat caagcgcatc cgtggcaaca ccaacgatac tagggtgaga     9180

ggtggcgaca ttctgtactt cgatatgact atcaacaaca aagcctacaa cttgttcatg     9240

aaaaacgaga caatgtacgc cgacaaccat agcacggagg atatttacgc aatcggactg     9300

agggaacaga caaaggacat caacgataac attatcttcc agatccaacc tatgaacaac     9360

acgtactact acgcttcgca aatcttcaag tccaacttca acggagaaaa catttcgggt     9420

atctgttcca ttggcacata ccgcttccgt ctgggtggtg actggtatcg tcacaactac     9480

ctcgttccca ccgtgaagca gggtaactac gcttctttgc tggagtcgac ttccacgcac     9540

tggggattcg ttcctgtgtc agagggcgct ggctaccctt acgatgttcc cgactacgct     9600

ggttgggaac tccagcaagg tgcaggatgg tcccaccctc aattcgagaa gggtgccgga     9660

tggagtcacc cacagttcga gaaaggcgct ggatggagtc acccacagtt cgagaaataa     9720

ttagttgatg catagttaat tagatagctc gaggcatgcg gtaccaagat tggatctaga     9780

tgcatagtta attagatagc tcgaggcatg cggtaccaag cttgtcgaga agtactagag     9840

gatcataatc agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca     9900

cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc     9960

agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt    10020

ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggat    10080

ctgatcactg cttgagccta ggagatccga accagataag tgaaatctag ttccaaacta    10140

ttttgtcatt tttaattttc gtattagctt acgacgctac acccagttcc catctatttt    10200

gtcactcttc cctaaataat ccttaaaaac tccatttcca cccctcccag ttcccaacta    10260

ttttgtccgc ccacagcggg gcatttttct tcctgttatg tttttaatca aacatcctgc    10320

caactccatg tgacaaaccg tcatcttcgg ctactttttc tctgtcacag aatgaaaatt    10380

tttctgtcat ctcttcgtta ttaatgtttg taattgactg aatatcaacg cttatttgca    10440

gcctgaatgg cgaatgg                                                   10457


<210>  50
<211>  1876
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein construct

<400>  50

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala Ala Gly His His His His His His His His His 
            20                  25                  30          


His His Asp Val Gly Trp Glu Leu Gln Arg Arg Pro Leu Asn Cys Ile 
        35                  40                  45              


Val Ala Val Ser Gln Asn Met Gly Ile Gly Lys Asn Gly Asp Leu Pro 
    50                  55                  60                  


Trp Pro Pro Leu Arg Asn Glu Phe Lys Tyr Phe Gln Arg Met Thr Thr 
65                  70                  75                  80  


Thr Ser Ser Val Glu Gly Lys Gln Asn Leu Val Ile Met Gly Arg Lys 
                85                  90                  95      


Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg Leu Leu Lys Asp Arg Ile 
            100                 105                 110         


Asn Ile Val Leu Ser Arg Glu Leu Lys Glu Pro Pro Arg Gly Ala His 
        115                 120                 125             


Phe Leu Ala Lys Ser Leu Asp Asp Ala Leu Arg Leu Ile Glu Gln Pro 
    130                 135                 140                 


Glu Leu Ala Ser Lys Val Asp Met Val Trp Ile Val Gly Gly Ser Ser 
145                 150                 155                 160 


Val Tyr Gln Glu Ala Met Asn Gln Pro Gly His Leu Arg Leu Phe Val 
                165                 170                 175     


Thr Arg Ile Met Gln Glu Phe Glu Ser Asp Thr Phe Phe Pro Glu Ile 
            180                 185                 190         


Asp Leu Gly Lys Tyr Lys Leu Leu Pro Glu Tyr Pro Gly Val Leu Ser 
        195                 200                 205             


Glu Val Gln Glu Glu Lys Gly Ile Lys Tyr Lys Phe Glu Val Tyr Glu 
    210                 215                 220                 


Lys Lys Asp Gly Ala Ser Gly Phe Ala Asn Glu Leu Gly Pro Arg Leu 
225                 230                 235                 240 


Met Gly Lys Gly Ala Gly Gly Ala Ala Ala Gln Val Gln Leu Val Glu 
                245                 250                 255     


Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys 
            260                 265                 270         


Ala Ala Ser Gly Ile Asp Ser Ser Ser Tyr Cys Met Gly Trp Phe Arg 
        275                 280                 285             


Gln Arg Pro Gly Lys Glu Arg Glu Gly Val Ala Arg Ile Asn Gly Leu 
    290                 295                 300                 


Gly Gly Val Lys Thr Ala Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
305                 310                 315                 320 


Ile Ser Arg Asp Asn Ala Glu Asn Thr Val Tyr Leu Gln Met Asn Ser 
                325                 330                 335     


Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Lys Phe Ser 
            340                 345                 350         


Pro Gly Tyr Cys Gly Gly Ser Trp Ser Asn Phe Gly Tyr Trp Gly Gln 
        355                 360                 365             


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ala Ala Ala Gly Ser 
    370                 375                 380                 


Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val 
385                 390                 395                 400 


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp 
                405                 410                 415     


Ser Ser Ser Tyr Cys Met Gly Trp Phe Arg Gln Arg Pro Gly Lys Glu 
            420                 425                 430         


Arg Glu Gly Val Ala Arg Ile Asn Gly Leu Gly Gly Val Lys Thr Ala 
        435                 440                 445             


Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala 
    450                 455                 460                 


Glu Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
465                 470                 475                 480 


Ala Ile Tyr Tyr Cys Ala Ala Lys Phe Ser Pro Gly Tyr Cys Gly Gly 
                485                 490                 495     


Ser Trp Ser Asn Phe Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            500                 505                 510         


Gly Ala Gly Gln Gly Ala Gly Ala Gly Pro Ile Thr Ile Asn Asn Phe 
        515                 520                 525             


Asn Tyr Ser Asp Pro Val Asp Asn Lys Asn Ile Leu Tyr Leu Asp Thr 
    530                 535                 540                 


His Leu Asn Thr Leu Ala Asn Glu Pro Glu Lys Ala Phe Arg Ile Thr 
545                 550                 555                 560 


Gly Asn Ile Trp Val Ile Pro Asp Arg Phe Ser Arg Asn Ser Asn Pro 
                565                 570                 575     


Asn Leu Asn Lys Pro Pro Arg Val Thr Ser Pro Lys Ser Gly Tyr Tyr 
            580                 585                 590         


Asp Pro Asn Tyr Leu Ser Thr Asp Ser Asp Lys Asp Pro Phe Leu Lys 
        595                 600                 605             


Glu Ile Ile Lys Leu Phe Lys Arg Ile Asn Ser Arg Glu Ile Gly Glu 
    610                 615                 620                 


Glu Leu Ile Tyr Arg Leu Ser Thr Asp Ile Pro Phe Pro Gly Asn Asn 
625                 630                 635                 640 


Asn Thr Pro Ile Asn Thr Phe Asp Phe Asp Val Asp Phe Asn Ser Val 
                645                 650                 655     


Asp Val Lys Thr Arg Gln Gly Asn Asn Trp Val Lys Thr Gly Ser Ile 
            660                 665                 670         


Asn Pro Ser Val Ile Ile Thr Gly Pro Arg Glu Asn Ile Ile Asp Pro 
        675                 680                 685             


Glu Thr Ser Thr Phe Lys Leu Thr Asn Asn Thr Phe Ala Ala Gln Glu 
    690                 695                 700                 


Gly Phe Gly Ala Leu Ser Ile Ile Ser Ile Ser Pro Arg Phe Met Leu 
705                 710                 715                 720 


Thr Tyr Ser Asn Ala Thr Asn Asp Val Gly Glu Gly Arg Phe Ser Lys 
                725                 730                 735     


Ser Glu Phe Cys Met Asp Pro Ile Leu Ile Leu Met His Ala Leu Asn 
            740                 745                 750         


Gly Ala Met His Asn Leu Tyr Gly Ile Ala Ile Pro Asn Asp Gln Thr 
        755                 760                 765             


Ile Ser Ser Val Thr Ser Asn Ile Phe Tyr Ser Gln Tyr Asn Val Lys 
    770                 775                 780                 


Leu Glu Tyr Ala Glu Ile Tyr Ala Phe Gly Gly Pro Thr Ile Asp Leu 
785                 790                 795                 800 


Ile Pro Lys Ser Ala Arg Lys Tyr Phe Glu Glu Lys Ala Leu Asp Tyr 
                805                 810                 815     


Tyr Arg Ser Ile Ala Lys Arg Leu Asn Ser Ile Thr Thr Ala Asn Pro 
            820                 825                 830         


Ser Ser Phe Asn Lys Tyr Ile Gly Glu Tyr Lys Gln Lys Leu Ile Arg 
        835                 840                 845             


Lys Tyr Arg Phe Val Val Glu Ser Ser Gly Glu Val Thr Val Asn Arg 
    850                 855                 860                 


Asn Lys Phe Val Glu Leu Tyr Asn Glu Leu Thr Gln Ile Phe Thr Glu 
865                 870                 875                 880 


Phe Asn Tyr Ala Lys Ile Tyr Asn Val Gln Asn Arg Lys Ile Ala Leu 
                885                 890                 895     


Ser Asn Val Tyr Thr Pro Val Thr Ala Asn Ile Leu Asp Asp Asn Val 
            900                 905                 910         


Tyr Asp Ile Gln Asn Gly Phe Asn Ile Pro Lys Ser Asn Leu Asn Val 
        915                 920                 925             


Leu Phe Met Gly Gln Asn Leu Ser Arg Asn Pro Ala Leu Arg Lys Val 
    930                 935                 940                 


Asn Pro Glu Asn Met Leu Tyr Leu Phe Thr Lys Phe Cys His Lys Ala 
945                 950                 955                 960 


Ile Asp Gly Gln Ser Leu Asp Gln Gly Gly Trp Glu Leu Gln Gln Gly 
                965                 970                 975     


Gly Gln Gly Gly Gly Ala Gly Thr Leu Asp Cys Arg Glu Leu Leu Val 
            980                 985                 990         


Lys Asn Thr Asp Leu Pro Phe Ile  Gly Asp Ile Ser Asp  Val Lys Thr 
        995                 1000                 1005             


Asp Ile  Phe Leu Arg Lys Asp  Ile Asn Glu Glu Thr  Glu Val Ile 
    1010                 1015                 1020             


Tyr Tyr  Pro Asp Asn Val Ser  Val Asp Gln Val Ile  Leu Ser Lys 
    1025                 1030                 1035             


Asn Thr  Ser Glu His Gly Gln  Leu Asp Leu Leu Tyr  Pro Ser Ile 
    1040                 1045                 1050             


Asp Ser  Glu Ser Glu Ile Leu  Pro Gly Glu Asn Gln  Val Phe Tyr 
    1055                 1060                 1065             


Asp Asn  Arg Thr Gln Asn Val  Asp Tyr Leu Asn Ser  Tyr Tyr Tyr 
    1070                 1075                 1080             


Leu Glu  Ser Gln Lys Leu Ser  Asp Asn Val Glu Asp  Phe Thr Phe 
    1085                 1090                 1095             


Thr Arg  Ser Ile Glu Glu Ala  Leu Asp Asn Ser Ala  Lys Val Tyr 
    1100                 1105                 1110             


Thr Tyr  Phe Pro Thr Leu Ala  Asn Lys Val Asn Ala  Gly Val Gln 
    1115                 1120                 1125             


Gly Gly  Leu Phe Leu Met Trp  Ala Asn Asp Val Val  Glu Asp Phe 
    1130                 1135                 1140             


Thr Thr  Asn Ile Leu Arg Lys  Asp Thr Leu Asp Lys  Ile Ser Asp 
    1145                 1150                 1155             


Val Ser  Ala Ile Ile Pro Tyr  Ile Gly Pro Ala Leu  Asn Ile Ser 
    1160                 1165                 1170             


Asn Ser  Val Arg Arg Gly Asn  Phe Thr Glu Ala Phe  Ala Val Thr 
    1175                 1180                 1185             


Gly Val  Thr Ile Leu Leu Glu  Ala Phe Pro Glu Phe  Thr Ile Pro 
    1190                 1195                 1200             


Ala Leu  Gly Ala Phe Val Ile  Tyr Ser Lys Val Gln  Glu Arg Asn 
    1205                 1210                 1215             


Glu Ile  Ile Lys Thr Ile Asp  Asn Cys Leu Glu Gln  Arg Ile Lys 
    1220                 1225                 1230             


Arg Trp  Lys Asp Ser Tyr Glu  Trp Met Met Gly Thr  Trp Leu Ser 
    1235                 1240                 1245             


Arg Ile  Ile Thr Gln Phe Asn  Asn Ile Ser Tyr Gln  Met Tyr Asp 
    1250                 1255                 1260             


Ser Leu  Asn Tyr Gln Ala Gly  Ala Ile Lys Ala Lys  Ile Asp Leu 
    1265                 1270                 1275             


Glu Tyr  Lys Lys Tyr Ser Gly  Ser Asp Lys Glu Asn  Ile Lys Ser 
    1280                 1285                 1290             


Gln Val  Glu Asn Leu Lys Asn  Ser Leu Asp Val Lys  Ile Ser Glu 
    1295                 1300                 1305             


Ala Met  Asn Asn Ile Asn Lys  Phe Ile Arg Glu Cys  Ser Val Thr 
    1310                 1315                 1320             


Tyr Leu  Phe Lys Asn Met Leu  Pro Lys Val Ile Asp  Glu Leu Asn 
    1325                 1330                 1335             


Glu Phe  Asp Arg Asn Thr Lys  Ala Lys Leu Ile Asn  Leu Ile Asp 
    1340                 1345                 1350             


Ser His  Asn Ile Ile Leu Val  Gly Glu Val Asp Lys  Leu Lys Ala 
    1355                 1360                 1365             


Lys Val  Asn Asn Ser Phe Gln  Asn Thr Ile Pro Phe  Asn Ile Phe 
    1370                 1375                 1380             


Ser Tyr  Thr Asn Asn Ser Leu  Leu Lys Asp Ile Ile  Asn Glu Tyr 
    1385                 1390                 1395             


Phe Asn  Asn Ile Asn Asp Ser  Lys Ile Leu Ser Leu  Gln Asn Arg 
    1400                 1405                 1410             


Lys Asn  Thr Leu Val Asp Thr  Ser Gly Tyr Asn Ala  Glu Val Ser 
    1415                 1420                 1425             


Glu Glu  Gly Asp Val Gln Leu  Asn Pro Ile Phe Pro  Phe Asp Phe 
    1430                 1435                 1440             


Lys Leu  Gly Ser Ser Gly Glu  Asp Arg Gly Lys Val  Ile Val Thr 
    1445                 1450                 1455             


Gln Asn  Glu Asn Ile Val Tyr  Asn Ser Met Tyr Glu  Ser Phe Ser 
    1460                 1465                 1470             


Ile Ser  Phe Trp Ile Arg Ile  Asn Lys Trp Val Ser  Asn Leu Pro 
    1475                 1480                 1485             


Gly Tyr  Thr Ile Ile Asp Ser  Val Lys Asn Asn Ser  Gly Trp Ser 
    1490                 1495                 1500             


Ile Gly  Ile Ile Ser Asn Phe  Leu Val Phe Thr Leu  Lys Gln Asn 
    1505                 1510                 1515             


Glu Asp  Ser Glu Gln Ser Ile  Asn Phe Ser Tyr Asp  Ile Ser Asn 
    1520                 1525                 1530             


Asn Ala  Pro Gly Tyr Asn Lys  Trp Phe Phe Val Thr  Val Thr Asn 
    1535                 1540                 1545             


Asn Met  Met Gly Asn Met Lys  Ile Tyr Ile Asn Gly  Lys Leu Ile 
    1550                 1555                 1560             


Asp Thr  Ile Lys Val Lys Glu  Leu Thr Gly Ile Asn  Phe Ser Lys 
    1565                 1570                 1575             


Thr Ile  Thr Phe Glu Ile Asn  Lys Ile Pro Asp Thr  Gly Leu Ile 
    1580                 1585                 1590             


Thr Ser  Asp Ser Asp Asn Ile  Asn Met Trp Ile Arg  Asp Phe Tyr 
    1595                 1600                 1605             


Ile Phe  Ala Lys Glu Leu Asp  Gly Lys Asp Ile Asn  Ile Leu Phe 
    1610                 1615                 1620             


Asn Ser  Leu Gln Tyr Thr Asn  Val Val Lys Asp Tyr  Trp Gly Asn 
    1625                 1630                 1635             


Asp Leu  Arg Tyr Asn Lys Glu  Tyr Tyr Met Val Asn  Ile Asp Tyr 
    1640                 1645                 1650             


Leu Asn  Arg Tyr Met Tyr Ala  Asn Ser Arg Gln Ile  Val Phe Asn 
    1655                 1660                 1665             


Thr Arg  Arg Asn Asn Asn Asp  Phe Asn Glu Gly Tyr  Lys Ile Ile 
    1670                 1675                 1680             


Ile Lys  Arg Ile Arg Gly Asn  Thr Asn Asp Thr Arg  Val Arg Gly 
    1685                 1690                 1695             


Gly Asp  Ile Leu Tyr Phe Asp  Met Thr Ile Asn Asn  Lys Ala Tyr 
    1700                 1705                 1710             


Asn Leu  Phe Met Lys Asn Glu  Thr Met Tyr Ala Asp  Asn His Ser 
    1715                 1720                 1725             


Thr Glu  Asp Ile Tyr Ala Ile  Gly Leu Arg Glu Gln  Thr Lys Asp 
    1730                 1735                 1740             


Ile Asn  Asp Asn Ile Ile Phe  Gln Ile Gln Pro Met  Asn Asn Thr 
    1745                 1750                 1755             


Tyr Tyr  Tyr Ala Ser Gln Ile  Phe Lys Ser Asn Phe  Asn Gly Glu 
    1760                 1765                 1770             


Asn Ile  Ser Gly Ile Cys Ser  Ile Gly Thr Tyr Arg  Phe Arg Leu 
    1775                 1780                 1785             


Gly Gly  Asp Trp Tyr Arg His  Asn Tyr Leu Val Pro  Thr Val Lys 
    1790                 1795                 1800             


Gln Gly  Asn Tyr Ala Ser Leu  Leu Glu Ser Thr Ser  Thr His Trp 
    1805                 1810                 1815             


Gly Phe  Val Pro Val Ser Glu  Gly Ala Gly Tyr Pro  Tyr Asp Val 
    1820                 1825                 1830             


Pro Asp  Tyr Ala Gly Trp Glu  Leu Gln Gln Gly Ala  Gly Trp Ser 
    1835                 1840                 1845             


His Pro  Gln Phe Glu Lys Gly  Ala Gly Trp Ser His  Pro Gln Phe 
    1850                 1855                 1860             


Glu Lys  Gly Ala Gly Trp Ser  His Pro Gln Phe Glu  Lys 
    1865                 1870                 1875     


<210>  51
<211>  8
<212>  PRT
<213>  Clostridium botulinum


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  51

His Glu Xaa Xaa His Xaa Xaa His 
1               5               


<210>  52
<211>  1296
<212>  PRT
<213>  Clostridium botulinum

<400>  52

Met Pro Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly 
1               5                   10                  15      


Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met Gln Pro 
            20                  25                  30          


Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro Glu Arg 
        35                  40                  45              


Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu 
    50                  55                  60                  


Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr 
65                  70                  75                  80  


Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu Phe Glu 
                85                  90                  95      


Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr Ser Ile Val 
            100                 105                 110         


Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys 
        115                 120                 125             


Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr 
    130                 135                 140                 


Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala Asp Ile 
145                 150                 155                 160 


Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn Leu Thr 
                165                 170                 175     


Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro Asp Phe 
            180                 185                 190         


Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro Leu Leu 
        195                 200                 205             


Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala His Glu 
    210                 215                 220                 


Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala Ile Asn Pro Asn 
225                 230                 235                 240 


Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser Gly Leu 
                245                 250                 255     


Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp Ala Lys 
            260                 265                 270         


Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn 
        275                 280                 285             


Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser Ile Val 
    290                 295                 300                 


Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys Glu Lys 
305                 310                 315                 320 


Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp Lys Leu 
                325                 330                 335     


Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr Thr Glu Asp 
            340                 345                 350         


Asn Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys Thr Tyr Leu Asn 
        355                 360                 365             


Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val Asn Tyr 
    370                 375                 380                 


Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn 
385                 390                 395                 400 


Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr Lys Leu 
                405                 410                 415     


Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys Val Arg 
            420                 425                 430         


Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Asp Lys Gly Tyr Asn Lys 
        435                 440                 445             


Ala Leu Asn Asp Leu Cys Ile Lys Val Asn Asn Trp Asp Leu Phe Phe 
    450                 455                 460                 


Ser Pro Ser Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu 
465                 470                 475                 480 


Ile Thr Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu 
                485                 490                 495     


Asp Leu Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro 
            500                 505                 510         


Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu 
        515                 520                 525             


Glu Leu Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu 
    530                 535                 540                 


Leu Asp Lys Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu 
545                 550                 555                 560 


His Gly Lys Ser Arg Ile Ala Leu Thr Asn Ser Val Asn Glu Ala Leu 
                565                 570                 575     


Leu Asn Pro Ser Arg Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys 
            580                 585                 590         


Lys Val Asn Lys Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu 
        595                 600                 605             


Gln Leu Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr 
    610                 615                 620                 


Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala 
625                 630                 635                 640 


Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu 
                645                 650                 655     


Ile Phe Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala 
            660                 665                 670         


Ile Pro Val Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys 
        675                 680                 685             


Val Leu Thr Val Gln Thr Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu 
    690                 695                 700                 


Lys Trp Asp Glu Val Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys 
705                 710                 715                 720 


Val Asn Thr Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu 
                725                 730                 735     


Glu Asn Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn 
            740                 745                 750         


Gln Tyr Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp 
        755                 760                 765             


Leu Ser Ser Lys Leu Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile 
    770                 775                 780                 


Asn Lys Phe Leu Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met 
785                 790                 795                 800 


Ile Pro Tyr Gly Val Lys Arg Leu Glu Asp Phe Asp Ala Ser Leu Lys 
                805                 810                 815     


Asp Ala Leu Leu Lys Tyr Ile Tyr Asp Asn Arg Gly Thr Leu Ile Gly 
            820                 825                 830         


Gln Val Asp Arg Leu Lys Asp Lys Val Asn Asn Thr Leu Ser Thr Asp 
        835                 840                 845             


Ile Pro Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser 
    850                 855                 860                 


Thr Phe Thr Glu Tyr Ile Lys Asn Ile Ile Asn Thr Ser Ile Leu Asn 
865                 870                 875                 880 


Leu Arg Tyr Glu Ser Asn His Leu Ile Asp Leu Ser Arg Tyr Ala Ser 
                885                 890                 895     


Lys Ile Asn Ile Gly Ser Lys Val Asn Phe Asp Pro Ile Asp Lys Asn 
            900                 905                 910         


Gln Ile Gln Leu Phe Asn Leu Glu Ser Ser Lys Ile Glu Val Ile Leu 
        915                 920                 925             


Lys Asn Ala Ile Val Tyr Asn Ser Met Tyr Glu Asn Phe Ser Thr Ser 
    930                 935                 940                 


Phe Trp Ile Arg Ile Pro Lys Tyr Phe Asn Ser Ile Ser Leu Asn Asn 
945                 950                 955                 960 


Glu Tyr Thr Ile Ile Asn Cys Met Glu Asn Asn Ser Gly Trp Lys Val 
                965                 970                 975     


Ser Leu Asn Tyr Gly Glu Ile Ile Trp Thr Leu Gln Asp Thr Gln Glu 
            980                 985                 990         


Ile Lys Gln Arg Val Val Phe Lys  Tyr Ser Gln Met Ile  Asn Ile Ser 
        995                 1000                 1005             


Asp Tyr  Ile Asn Arg Trp Ile  Phe Val Thr Ile Thr  Asn Asn Arg 
    1010                 1015                 1020             


Leu Asn  Asn Ser Lys Ile Tyr  Ile Asn Gly Arg Leu  Ile Asp Gln 
    1025                 1030                 1035             


Lys Pro  Ile Ser Asn Leu Gly  Asn Ile His Ala Ser  Asn Asn Ile 
    1040                 1045                 1050             


Met Phe  Lys Leu Asp Gly Cys  Arg Asp Thr His Arg  Tyr Ile Trp 
    1055                 1060                 1065             


Ile Lys  Tyr Phe Asn Leu Phe  Asp Lys Glu Leu Asn  Glu Lys Glu 
    1070                 1075                 1080             


Ile Lys  Asp Leu Tyr Asp Asn  Gln Ser Asn Ser Gly  Ile Leu Lys 
    1085                 1090                 1095             


Asp Phe  Trp Gly Asp Tyr Leu  Gln Tyr Asp Lys Pro  Tyr Tyr Met 
    1100                 1105                 1110             


Leu Asn  Leu Tyr Asp Pro Asn  Lys Tyr Val Asp Val  Asn Asn Val 
    1115                 1120                 1125             


Gly Ile  Arg Gly Tyr Met Tyr  Leu Lys Gly Pro Arg  Gly Ser Val 
    1130                 1135                 1140             


Met Thr  Thr Asn Ile Tyr Leu  Asn Ser Ser Leu Tyr  Arg Gly Thr 
    1145                 1150                 1155             


Lys Phe  Ile Ile Lys Lys Tyr  Ala Ser Gly Asn Lys  Asp Asn Ile 
    1160                 1165                 1170             


Val Arg  Asn Asn Asp Arg Val  Tyr Ile Asn Val Val  Val Lys Asn 
    1175                 1180                 1185             


Lys Glu  Tyr Arg Leu Ala Thr  Asn Ala Ser Gln Ala  Gly Val Glu 
    1190                 1195                 1200             


Lys Ile  Leu Ser Ala Leu Glu  Ile Pro Asp Val Gly  Asn Leu Ser 
    1205                 1210                 1215             


Gln Val  Val Val Met Lys Ser  Lys Asn Asp Gln Gly  Ile Thr Asn 
    1220                 1225                 1230             


Lys Cys  Lys Met Asn Leu Gln  Asp Asn Asn Gly Asn  Asp Ile Gly 
    1235                 1240                 1245             


Phe Ile  Gly Phe His Gln Phe  Asn Asn Ile Ala Lys  Leu Val Ala 
    1250                 1255                 1260             


Ser Asn  Trp Tyr Asn Arg Gln  Ile Glu Arg Ser Ser  Arg Thr Leu 
    1265                 1270                 1275             


Gly Cys  Ser Trp Glu Phe Ile  Pro Val Asp Asp Gly  Trp Gly Glu 
    1280                 1285                 1290             


Arg Pro  Leu 
    1295     


<210>  53
<211>  806
<212>  PRT
<213>  Clostridium botulinum

<400>  53

Met Val Thr Asn Asn Asn Tyr Asn Asp Asp Asn Asp Asn Met Met Ala 
1               5                   10                  15      


Arg Gly Thr Gly Arg Tyr Tyr Lys Ala Lys Thr Asp Arg Trp Arg Tyr 
            20                  25                  30          


Thr Gly Tyr Lys Asp Asn Lys Ser Ser Gly Asn Arg Asp Val Cys Tyr 
        35                  40                  45              


Tyr Asp Asp Tyr Asn Thr Asn Asp Lys Lys Asn Thr Lys Asn Arg Lys 
    50                  55                  60                  


Ser Lys Gly Lys Met Asn Gly Tyr Gly Asp Arg Arg Val Asn Thr Asn 
65                  70                  75                  80  


Ala Ser Val Thr Val Asn Lys Ser Asn Gly Val Arg Lys Lys Gly Ala 
                85                  90                  95      


Asn Gly Gly Val Asn Asn Thr Asp Gly Asn His Ala Ser Arg Gly Gly 
            100                 105                 110         


Gly Met Met Lys Cys Tyr Val Ser Val Asn Asn Val Asn Lys Gly Ala 
        115                 120                 125             


Ser Asn Arg Arg Gly Tyr Ser Asp Ala Met His His Val His Gly Tyr 
    130                 135                 140                 


Gly Lys Val Asp Asp Val Asn Lys Lys Met Ser Thr Asp Thr Ala Tyr 
145                 150                 155                 160 


Thr Gly Gly Asp Ser Ser Ser Thr Asp Lys Ser Tyr Asp Lys Val Asn 
                165                 170                 175     


Arg Gly Val Asp Arg Asn Lys Val Val Cys Ser Asp Asn Asn Asn Tyr 
            180                 185                 190         


Lys Asn Lys Lys Asp Lys Tyr Lys Val Asp Ser Gly Lys Tyr Ser Asp 
        195                 200                 205             


Val Ser Asn Lys Tyr Lys Ser Met Gly Thr Asn Ala Asn Tyr Lys Lys 
    210                 215                 220                 


Thr Arg Ala Ser Tyr Ser Asp Ser Val Lys Lys Asn Asp Asn Tyr Thr 
225                 230                 235                 240 


Gly Asn Ser Asp Lys Asn Met Gly Lys Tyr Arg Gly Asn Lys Ala Asn 
                245                 250                 255     


Lys Ala Tyr Ser Lys His Ala Val Tyr Lys Met Cys Lys Ser Val Lys 
            260                 265                 270         


Val Gly Cys Asp Val Asp Asn Asn Ala Asp Lys Asn Ser Ser Asp Asp 
        275                 280                 285             


Ser Lys Asn Arg Val Tyr Asn Thr Asn Asn Tyr Gly Asn Asp Asn Asp 
    290                 295                 300                 


Thr Asp Ser Lys Ser Asn Thr Ser Thr Asp Asn Val Asp Val Val Tyr 
305                 310                 315                 320 


Lys Ala Lys Lys Val Thr Asp Asn Thr Tyr Tyr Ser Thr Asn Arg Asp 
                325                 330                 335     


Ser Thr Ser Ser Asp Asp Ala Val Ser Ser Lys Val Tyr Ser Ser Met 
            340                 345                 350         


Asp Tyr Lys Thr Ala Asn Lys Val Val Ala Gly Ala Gly Trp Val Lys 
        355                 360                 365             


Val Asp Asp Val Ala Asn Lys Ser Ser Thr Met Asp Lys Ala Asp Ser 
    370                 375                 380                 


Val Tyr Gly Ala Asn Val Gly Asp Thr Ala Lys Gly Asn Ser Ala Ala 
385                 390                 395                 400 


Gly Ser Ser Val Val Gly Val Ser Tyr Asp Asn Lys Asn Lys Lys Thr 
                405                 410                 415     


Asp Asn Ala Thr Lys Arg Val Lys Trp Asp Met Tyr Gly Val Ala Trp 
            420                 425                 430         


Ser Thr Val Asn Thr Tyr Thr Lys Gly Met Tyr Lys Ala Asn Tyr Ala 
        435                 440                 445             


Ala Lys Tyr Lys Tyr Asn Tyr Ser Lys Ser Asn Asn Asn Asn Asp Asn 
    450                 455                 460                 


Ser Lys Asn Asp Gly Asn Ala Met Asp Asn Asn Asp Asn Cys Ser Val 
465                 470                 475                 480 


Ser Tyr Met Lys Lys Met Ala Val Lys Lys Asp Asp Asn Thr Lys Lys 
                485                 490                 495     


Asn Asn Tyr Asp Asn Lys Tyr Gly Ser Val Asp Lys Ser Lys Val Asp 
            500                 505                 510         


Lys Tyr Lys Thr Asp Ser Thr Tyr Ser Asn Lys Asn Lys Tyr Asn Ser 
        515                 520                 525             


Asn Asn Asn Arg Tyr Arg Asp Asn Asn Asp Ser Gly Tyr Gly Ala Lys 
    530                 535                 540                 


Val Val Tyr Asp Gly Val Lys Asn Asp Lys Asn Lys Thr Ser Ser Ala 
545                 550                 555                 560 


Asp Ser Lys Arg Val Thr Asn Asn Asn Ser Met Asp Ser Val Ser Trp 
                565                 570                 575     


Arg Lys Tyr Arg Asn Asp Asp Asn Tyr His Asn Tyr Thr Asn Cys Met 
            580                 585                 590         


Lys Asn Asn Ser Gly Trp Lys Ser Arg Gly Asn Arg Trp Thr Asp Asn 
        595                 600                 605             


Gly Lys Thr Lys Ser Val Tyr Asn Arg Asp Ser Tyr Asn Arg Trp Val 
    610                 615                 620                 


Thr Thr Asn Asn Asp Asn Ala Lys Tyr Asn Gly Thr Ser Asn Met Asp 
625                 630                 635                 640 


Lys Asp Gly Val Val Asn Gly Thr Lys Asp Gly Asp Val Asp Arg Thr 
                645                 650                 655     


Trp Met Lys Tyr Ser Asn Thr Asn Ser Asn Lys Tyr Lys Ser Tyr Ser 
            660                 665                 670         


Tyr Lys Asp Trp Gly Asn Met Tyr Asn Lys Tyr Tyr Met Asn Ala Gly 
        675                 680                 685             


Asn Lys Asn Ser Tyr Lys Val Lys Asp Ser Ser Val Gly Arg Ser Lys 
    690                 695                 700                 


Tyr Asn Asn Ser Asn Tyr Asn Tyr Arg Asn Tyr Gly Lys Arg Arg Ser 
705                 710                 715                 720 


Asn Ser Ser Asn Asp Asp Val Arg Lys Asp Tyr His Asp Val His His 
                725                 730                 735     


Trp Arg Val Tyr Ala Tyr Lys Tyr Lys Lys Ser Ser Asp Ser Asn Tyr 
            740                 745                 750         


Lys Thr Lys Tyr Asp Ser Tyr Ser Cys Lys Lys Asp Ser Thr Asp Asp 
        755                 760                 765             


Gly Gly His Arg Tyr Ser Gly Val Arg Lys Lys Tyr Lys Asp Tyr Cys 
    770                 775                 780                 


Ser Lys Trp Tyr Lys Val Lys Arg Lys Tyr Lys Ser Asn Gly Cys Asn 
785                 790                 795                 800 


Trp Lys Asp Gly Trp Thr 
                805     


<210>  54
<211>  848
<212>  PRT
<213>  Clostridium botulinum

<400>  54

Met Thr Asn Asn Asn Tyr Ser Asp Val Asp Asn Lys Asn Tyr Asp Thr 
1               5                   10                  15      


His Asn Thr Ala Asn Lys Ala Arg Thr Gly Asn Trp Val Asp Arg Ser 
            20                  25                  30          


Arg Asn Ser Asn Asn Asn Lys Arg Val Thr Ser Lys Ser Gly Tyr Tyr 
        35                  40                  45              


Asp Asn Tyr Ser Thr Asp Ser Asp Lys Asp Thr Lys Lys Lys Arg Asn 
    50                  55                  60                  


Ser Arg Gly Tyr Arg Ser Thr Asp Gly Asn Asn Asn Thr Asn Thr Asp 
65                  70                  75                  80  


Asp Val Asp Asn Ser Val Asp Val Lys Thr Arg Gly Asn Asn Trp Val 
                85                  90                  95      


Lys Thr Gly Ser Asn Ser Val Thr Gly Arg Asn Asp Thr Ser Thr Lys 
            100                 105                 110         


Thr Asn Asn Thr Ala Ala Gly Gly Ala Ser Ser Ser Arg Met Thr Tyr 
        115                 120                 125             


Ser Asn Ala Thr Asn Asp Val Gly Gly Arg Ser Lys Ser Cys Met Asp 
    130                 135                 140                 


Met His Asn His Ala Met His Asn Tyr Gly Ala Asn Asp Thr Ser Ser 
145                 150                 155                 160 


Val Thr Ser Asn Tyr Ser Tyr Asn Val Lys Tyr Ala Tyr Ala Gly Gly 
                165                 170                 175     


Thr Asp Lys Ser Ala Arg Lys Tyr Lys Ala Asp Tyr Tyr Arg Ser Ala 
            180                 185                 190         


Lys Arg Asn Ser Thr Thr Ala Asn Ser Ser Asn Lys Tyr Gly Tyr Lys 
        195                 200                 205             


Lys Arg Lys Tyr Arg Val Val Ser Ser Gly Val Thr Val Asn Arg Asn 
    210                 215                 220                 


Lys Val Tyr Asn Thr Thr Asn Tyr Ala Lys Tyr Asn Val Asn Arg Lys 
225                 230                 235                 240 


Tyr Ser Asn Val Tyr Thr Val Thr Ala Asn Asp Asp Asn Val Tyr Asp 
                245                 250                 255     


Asn Gly Asn Lys Ser Asn Asn Val Met Gly Asn Ser Arg Asn Ala Arg 
            260                 265                 270         


Lys Val Asn Asn Met Tyr Thr Lys Cys His Lys Ala Asp Gly Arg Ser 
        275                 280                 285             


Tyr Asn Lys Thr Asp Cys Arg Val Lys Asn Thr Asp Gly Asp Ser Asp 
    290                 295                 300                 


Val Lys Thr Asp Arg Lys Asp Asn Thr Val Tyr Tyr Asp Asn Val Ser 
305                 310                 315                 320 


Val Asp Val Ser Lys Asn Thr Ser His Gly Asp Tyr Ser Asp Ser Ser 
                325                 330                 335     


Gly Asn Val Tyr Asp Asn Arg Thr Asn Val Asp Tyr Asn Ser Tyr Tyr 
            340                 345                 350         


Tyr Ser Lys Ser Asp Asn Val Asp Thr Thr Arg Ser Ala Asp Asn Ser 
        355                 360                 365             


Ala Lys Val Tyr Thr Tyr Thr Ala Asn Lys Val Asn Ala Gly Val Gly 
    370                 375                 380                 


Gly Met Trp Ala Asn Asp Val Val Asp Thr Thr Asn Arg Lys Asp Thr 
385                 390                 395                 400 


Asp Lys Ser Asp Val Ser Ala Tyr Gly Ala Asn Ser Asn Ser Val Arg 
                405                 410                 415     


Arg Gly Asn Thr Ala Ala Val Thr Gly Val Thr Ala Thr Ala Gly Ala 
            420                 425                 430         


Val Tyr Ser Lys Val Arg Asn Lys Thr Asp Asn Cys Arg Lys Arg Trp 
        435                 440                 445             


Lys Asp Ser Tyr Trp Met Met Gly Thr Trp Ser Arg Thr Asn Asn Ser 
    450                 455                 460                 


Tyr Met Tyr Asp Ser Asn Tyr Ala Gly Ala Lys Ala Lys Asp Tyr Lys 
465                 470                 475                 480 


Lys Tyr Ser Gly Ser Asp Lys Asn Lys Ser Val Asn Lys Asn Ser Asp 
                485                 490                 495     


Val Lys Ser Ala Met Asn Asn Asn Lys Arg Cys Ser Val Thr Tyr Lys 
            500                 505                 510         


Asn Met Lys Val Asp Asn Asp Arg Asn Thr Lys Ala Lys Asn Asp Ser 
        515                 520                 525             


His Asn Val Gly Val Asp Lys Lys Ala Lys Val Asn Asn Ser Asn Thr 
    530                 535                 540                 


Asn Ser Tyr Thr Asn Asn Ser Lys Asp Asn Tyr Asn Asn Asn Asp Ser 
545                 550                 555                 560 


Lys Ser Asn Arg Lys Asn Thr Val Asp Thr Ser Gly Tyr Asn Ala Val 
                565                 570                 575     


Ser Gly Asp Val Asn Asp Lys Gly Ser Ser Gly Asp Arg Gly Lys Val 
            580                 585                 590         


Val Thr Asn Asn Val Tyr Asn Ser Met Tyr Ser Ser Ser Trp Arg Asn 
        595                 600                 605             


Lys Trp Val Ser Asn Gly Tyr Thr Asp Ser Val Lys Asn Asn Ser Gly 
    610                 615                 620                 


Trp Ser Gly Ser Asn Val Thr Lys Asn Asp Ser Ser Asn Ser Tyr Asp 
625                 630                 635                 640 


Ser Asn Asn Ala Gly Tyr Asn Lys Trp Val Thr Val Thr Asn Asn Met 
                645                 650                 655     


Met Gly Asn Met Lys Tyr Asn Gly Lys Asp Thr Lys Val Lys Thr Gly 
            660                 665                 670         


Asn Ser Lys Thr Thr Asn Lys Asp Thr Gly Thr Ser Asp Ser Asp Asn 
        675                 680                 685             


Asn Met Trp Arg Asp Tyr Ala Lys Asp Gly Lys Asp Asn Asn Ser Tyr 
    690                 695                 700                 


Thr Asn Val Val Lys Asp Tyr Trp Gly Asn Asp Arg Tyr Asn Lys Tyr 
705                 710                 715                 720 


Tyr Met Val Asn Asp Tyr Asn Arg Tyr Met Tyr Ala Asn Ser Arg Val 
                725                 730                 735     


Asn Thr Arg Arg Asn Asn Asn Asp Asn Gly Tyr Lys Lys Arg Arg Gly 
            740                 745                 750         


Asn Thr Asn Asp Thr Arg Val Arg Gly Gly Asp Tyr Asp Met Thr Asn 
        755                 760                 765             


Asn Lys Ala Tyr Asn Met Lys Asn Thr Met Tyr Ala Asp Asn His Ser 
    770                 775                 780                 


Thr Asp Tyr Ala Gly Arg Thr Lys Asp Asn Asp Asn Met Asn Asn Thr 
785                 790                 795                 800 


Tyr Tyr Tyr Ala Ser Lys Ser Asn Asn Gly Asn Ser Gly Cys Ser Gly 
                805                 810                 815     


Thr Tyr Arg Arg Gly Gly Asp Trp Tyr Arg His Asn Tyr Val Thr Val 
            820                 825                 830         


Lys Gly Asn Tyr Ala Ser Ser Thr Ser Thr His Trp Gly Val Val Ser 
        835                 840                 845             


<210>  55
<211>  816
<212>  PRT
<213>  Clostridium botulinum

<400>  55

Met Thr Trp Val Lys Asp Asn Tyr Ser Asp Val Asn Asp Asn Asp Tyr 
1               5                   10                  15      


Arg Asn Lys Thr Thr Val Lys Ala Met Thr Asn Trp Val Arg Ser Ser 
            20                  25                  30          


Asp Thr Asn Ser Ser Lys Arg Thr Ser Lys Tyr Ser Tyr Tyr Asp Ser 
        35                  40                  45              


Tyr Ser Thr Asp Lys Asp Thr Lys Gly Lys Lys Arg Asn Arg Asp Gly 
    50                  55                  60                  


Lys Lys Asn Tyr Val Val Gly Ser Met Gly Asp Ser Ser Thr Asp Thr 
65                  70                  75                  80  


Asp Thr Arg His Thr Thr Asn Ala Val Lys Asn Gly Ser Trp Lys Val 
                85                  90                  95      


Thr Asn Thr Ser Val Gly Asn Asp Tyr Thr Ala Ser Thr Gly Ser Asn 
            100                 105                 110         


Ser Gly Gly Thr Ser Lys Val Ala Thr Ser Asp Val Thr Ser Asn Ser 
        115                 120                 125             


Ser Ala Val Gly Lys Ser Cys Met Asp Val Ala Met His Thr His Ser 
    130                 135                 140                 


His Tyr Gly Asn Ser Asp Lys Arg Arg Val Ser Gly Ser Asp Gly Asn 
145                 150                 155                 160 


Val Tyr Thr Gly Gly Asp Val Arg Ser Arg Lys Ala Gly His Tyr Lys 
                165                 170                 175     


Asp Ala Lys Arg Asn Asn Asn Lys Thr Ser Ser Trp Ser Asn Asp Lys 
            180                 185                 190         


Tyr Lys Lys Ser Lys Tyr Asn Asp Lys Asp Asn Thr Gly Asn Val Val 
        195                 200                 205             


Asn Asp Lys Asn Ser Tyr Ser Asp Thr Asn Val Met Ser Val Val Tyr 
    210                 215                 220                 


Ser Ser Tyr Asn Val Lys Asn Arg Thr His Tyr Ser Arg His Tyr Val 
225                 230                 235                 240 


Ala Asn Asp Asp Asn Tyr Thr Arg Asp Gly Asn Thr Asn Lys Gly Asn 
                245                 250                 255     


Asn Ser Gly Asn Arg Asn Ala Lys Ser Ser Ser Val Val Asp Thr Lys 
            260                 265                 270         


Val Cys Arg Thr Lys Asn Ser Arg Asp Asp Ser Thr Cys Lys Val Lys 
        275                 280                 285             


Asn Asn Arg Tyr Val Ala Asp Lys Asp Ser Ser Asn Lys Thr Asp Thr 
    290                 295                 300                 


Asn Val Asn Tyr Ser Asp Lys Ser Asp Ser Asp Gly Val Asn Val Asp 
305                 310                 315                 320 


Asn Val Asn Met Asn Gly Val Tyr Asp Asp Thr Lys Tyr Val Asp Tyr 
                325                 330                 335     


Asn Ser Tyr Tyr Tyr Ser Lys Ser Asn Asn Val Asn Thr Thr Thr Ser 
            340                 345                 350         


Val Ala Gly Tyr Ser Asn Lys Tyr Thr Ser Ala Lys Val Asn Lys Gly 
        355                 360                 365             


Val Ala Gly Asn Trp Ala Asn Val Val Asp Thr Thr Asn Met Lys Lys 
    370                 375                 380                 


Asp Thr Asp Lys Ser Asp Val Ser Val Tyr Gly Ala Asn Gly Asn Ser 
385                 390                 395                 400 


Ala Arg Gly Asn Asn Ala Ala Thr Ala Gly Val Ala Gly Thr Ala Gly 
                405                 410                 415     


Val Thr Tyr Ser Ser Arg Lys Lys Thr Asn Cys Arg Val Lys Arg Trp 
            420                 425                 430         


Lys Asp Ser Tyr Trp Met Val Ser Asn Trp Ser Arg Thr Thr Asn His 
        435                 440                 445             


Asn Tyr Met Tyr Asp Ser Ser Tyr Ala Asp Ala Lys Ala Lys Asp Tyr 
    450                 455                 460                 


Lys Lys Tyr Ser Gly Ser Asp Lys Asn Lys Ser Val Asn Lys Asn Ser 
465                 470                 475                 480 


Asp Val Lys Ser Ala Met Asn Asn Asn Lys Arg Cys Ser Val Thr Tyr 
                485                 490                 495     


Lys Asn Met Lys Val Asp Asn Lys Asp Arg Thr Lys Thr Asn Asp Ser 
            500                 505                 510         


His Asn Val Gly Val Asp Arg Lys Ala Lys Val Asn Ser Asn Thr Met 
        515                 520                 525             


Asn Ser Tyr Thr Asn Asn Ser Lys Asp Asn Tyr Asn Ser Asn Asp Ser 
    530                 535                 540                 


Lys Ser Asn Lys Lys Asn Ala Val Asp Thr Ser Gly Tyr Asn Ala Val 
545                 550                 555                 560 


Arg Val Gly Asp Asn Val Asn Thr Tyr Thr Asn Asp Lys Ser Ser Ser 
                565                 570                 575     


Gly Asp Lys Val Asn Asn Asn Asn Tyr Ser Ala Tyr Asn Ser Ser Val 
            580                 585                 590         


Ser Trp Lys Ser Lys Asp Thr Asn Ser His Asn Tyr Thr Asn Ser Asn 
        595                 600                 605             


Ser Gly Trp Lys Cys Arg Asn Gly Asn Trp Asp Val Asn Arg Lys Tyr 
    610                 615                 620                 


Lys Ser Asp Tyr Ser Ser Ser His Thr Gly Tyr Thr Asn Lys Trp Val 
625                 630                 635                 640 


Thr Thr Asn Asn Met Gly Tyr Met Lys Tyr Asn Gly Lys Ser Lys Asp 
                645                 650                 655     


Asp Val Lys Asp Lys Thr Val Gly Asp Asn Asp Asn Met Trp Arg Asp 
            660                 665                 670         


Asn Ser Lys Ser Asn Asp Asn Val Tyr Gly Arg Asn Val Lys Asp Tyr 
        675                 680                 685             


Trp Gly Asn Lys Asp Thr Tyr Tyr Asn Asp Asn Tyr Asp Arg Tyr Ala 
    690                 695                 700                 


Ser Asn Val Val Val Tyr Asp Arg Ser Lys Tyr Thr Gly Asn Thr Lys 
705                 710                 715                 720 


Ser Val Ser Asp Lys Asn Tyr Ser Arg Asn Gly Asp Asn His Met Tyr 
                725                 730                 735     


Asn Ser Arg Lys Tyr Met Arg Asp Thr Asp Thr Tyr Ala Thr Gly Gly 
            740                 745                 750         


Cys Ser Asn Cys Val Tyr Ala Lys Ser Asn Gly Asn Tyr Gly Gly Ser 
        755                 760                 765             


Lys Asn Val Ser Lys Asn Lys Tyr Cys Ser Ser Ser Arg Asn Thr Met 
    770                 775                 780                 


Ala Asp Tyr Lys Trp Arg Ser Lys Asn Ala Tyr Thr Val Ala Val Thr 
785                 790                 795                 800 


Asn Tyr Thr Lys Ser Thr Ser Ser Trp Lys Ser Arg Asp Gly Trp Val 
                805                 810                 815     


<210>  56
<211>  815
<212>  PRT
<213>  Clostridium botulinum

<400>  56

Met Lys Asn Ser Asn Tyr Asn Asp Val Asn Asp Arg Thr Tyr Lys Gly 
1               5                   10                  15      


Gly Cys Tyr Lys Ser Asn Met Lys Asn Trp Arg Asn Val Gly Thr Thr 
            20                  25                  30          


Asp His Thr Ser Lys Asn Gly Asp Ser Ser Tyr Tyr Asp Asn Tyr Ser 
        35                  40                  45              


Asp Lys Asp Arg Lys Val Thr Lys Asn Arg Asn Asn Asn Ser Gly Gly 
    50                  55                  60                  


Ser Lys Ala Asn Tyr Gly Asn Asp Asn Thr Asp Asn His Gly Asp Ala 
65                  70                  75                  80  


Ser Ala Val Lys Ser Asn Gly Ser Asp Asn Val Met Gly Ala Asp Thr 
                85                  90                  95      


Asn Ser Ser Asn Ser Arg Asn Asn Tyr Met Ser Asn His Gly Gly Ser 
            100                 105                 110         


Ala Val Thr Ser Tyr Ser Arg Asn Asp Asn Ser Met Asn Asp Ala Thr 
        115                 120                 125             


Met His His Ser His Gly Tyr Gly Ala Lys Gly Thr Thr Lys Tyr Thr 
    130                 135                 140                 


Thr Lys Asn Thr Asn Arg Gly Thr Asn Thr Gly Gly Thr Asp Asn Thr 
145                 150                 155                 160 


Ser Ala Ser Asn Asp Tyr Thr Asn Ala Asp Tyr Lys Lys Ala Ser Lys 
                165                 170                 175     


Ser Lys Val Val Ser Asn Asn Tyr Lys Asp Val Ala Lys Tyr Gly Asp 
            180                 185                 190         


Lys Asp Ala Ser Gly Tyr Ser Val Asn Asn Lys Asn Asp Lys Lys Tyr 
        195                 200                 205             


Ser Thr Asp Ala Thr Lys Val Lys Cys Arg Thr Tyr Gly Tyr Lys Tyr 
    210                 215                 220                 


Lys Ser Asn Asn Asp Ser Tyr Asn Ser Gly Tyr Asn Asn Asn Lys Val 
225                 230                 235                 240 


Asn Arg Gly Asn Ala Asn Asn Arg Thr Thr Gly Arg Gly Val Lys Lys 
                245                 250                 255     


Arg Cys Lys Asn Val Ser Val Lys Gly Arg Lys Ser Cys Asn Asn Gly 
            260                 265                 270         


Val Ala Ser Asn Ser Tyr Asn Asp Asp Asn Asn Thr Lys Asp Asp Thr 
        275                 280                 285             


Val Thr Ser Asn Asn Asn Tyr Asn Asp Asp Val Asn Asn Ser Ser Ala 
    290                 295                 300                 


Gly Ser Asp Lys Asn Thr Asn Asp Ala Tyr Lys Tyr Asp Ser Asn Gly 
305                 310                 315                 320 


Thr Ser Asp His Asp Val Asn Asn Val Tyr Asp Ala Lys Val Gly Asn 
                325                 330                 335     


Asn Val Asn Thr Ser Ser Asp Thr Ala Lys Tyr Thr Ser Ser Asn Asn 
            340                 345                 350         


Val Asn Lys Val Ala Ala Val Ser Trp Val Val Asp Thr Thr Ala Asn 
        355                 360                 365             


Lys Ser Thr Val Asp Lys Ala Asp Ser Val Val Tyr Gly Ala Asn Gly 
    370                 375                 380                 


Asn Ala Lys Gly Asn Lys Asp Ala Gly Ala Gly Thr Val Thr Lys Ser 
385                 390                 395                 400 


Gly Ser Ser Asp Asn Lys Asn Lys Val Lys Ala Asn Asn Ala Lys Arg 
                405                 410                 415     


Asp Lys Trp Lys Val Tyr Ser Val Ser Asn Trp Met Thr Lys Asn Thr 
            420                 425                 430         


Asn Lys Arg Lys Met Tyr Ala Asn Val Asn Ala Lys Thr Ser Lys Tyr 
        435                 440                 445             


Asn Ser Tyr Thr Lys Asn Thr Asn Lys Tyr Asp Lys Asn Asn Lys Val 
    450                 455                 460                 


Ser Ala Met Asn Asn Asp Arg Thr Ser Ser Ser Tyr Met Lys Asn Val 
465                 470                 475                 480 


Lys Asn Lys Arg Tyr Asp Asn Val Lys Thr Tyr Asn Tyr His Gly Ser 
                485                 490                 495     


Gly Ser Asn Ser Met Val Thr Asp Thr Asn Asn Ser Lys Ser Ser Tyr 
            500                 505                 510         


Thr Asp Asp Lys Ser Tyr Asn Lys Lys Arg Lys Ser Ser Ser Val Asn 
        515                 520                 525             


Met Arg Tyr Lys Asn Asp Lys Tyr Val Asp Thr Ser Gly Tyr Asp Ser 
    530                 535                 540                 


Asn Asn Asn Gly Asp Val Tyr Lys Tyr Thr Asn Lys Asn Gly Tyr Asn 
545                 550                 555                 560 


Asp Lys Ser Val Asn Ser Asn Asp Tyr Tyr Asp Asn Lys Tyr Lys Asn 
                565                 570                 575     


Ser Ser Trp Val Arg Asn Tyr Asp Asn Lys Val Asn Val Asn Asn Tyr 
            580                 585                 590         


Thr Asn Cys Met Arg Asp Asn Asn Ser Gly Trp Lys Val Ser Asn His 
        595                 600                 605             


Asn Trp Thr Asp Asn Ala Gly Asn Lys Ala Asn Tyr Gly Asn Ala Asn 
    610                 615                 620                 


Gly Ser Asp Tyr Asn Lys Trp Val Thr Thr Asn Asp Arg Gly Asp Ser 
625                 630                 635                 640 


Lys Tyr Asn Gly Asn Asp Lys Ser Asn Gly Asn His Val Ser Asp Asn 
                645                 650                 655     


Lys Val Asn Cys Ser Tyr Thr Arg Tyr Gly Arg Tyr Asn Asp Lys Asp 
            660                 665                 670         


Thr Thr Tyr Ser Asn Asn Thr Asn Lys Asp Trp Gly Asn Tyr Tyr Asp 
        675                 680                 685             


Lys Tyr Tyr Asn Val Lys Asn Asn Asp Arg Arg Lys Asp Ser Thr Ser 
    690                 695                 700                 


Asn Asn Arg Ser Thr Ala Asn Arg Tyr Ser Gly Lys Val Lys Arg Val 
705                 710                 715                 720 


Asn Asn Ser Ser Thr Asn Asp Asn Val Arg Lys Asn Asp Val Tyr Asn 
                725                 730                 735     


Val Ala Ser Lys Thr His Tyr Ala Asp Thr Ala Thr Thr Asn Lys Lys 
            740                 745                 750         


Thr Lys Ser Ser Ser Gly Asn Arg Asn Val Val Val Met Asn Ser Val 
        755                 760                 765             


Gly Asn Asn Cys Thr Met Asn Lys Asn Asn Asn Gly Asn Asn Gly Gly 
    770                 775                 780                 


Lys Ala Asp Thr Val Val Ala Ser Thr Trp Tyr Tyr Thr His Met Arg 
785                 790                 795                 800 


Asp His Thr Asn Ser Asn Gly Cys Trp Asn Ser His Gly Trp Lys 
                805                 810                 815 


<210>  57
<211>  828
<212>  PRT
<213>  Clostridium botulinum

<400>  57

Met Val Val Asn Ser Asn Tyr Asn Asp Val Asn Asp Asp Thr Tyr Met 
1               5                   10                  15      


Tyr Lys Ser Lys Lys Tyr Tyr Lys Ala Met Arg Asn Val Trp Arg Asn 
            20                  25                  30          


Thr Gly Thr Asp Ser Asp Asp Ala Ser Asn Gly Ser Ser Ala Tyr Tyr 
        35                  40                  45              


Asp Asn Tyr Thr Thr Asp Ala Lys Asp Arg Tyr Lys Thr Thr Lys Lys 
    50                  55                  60                  


Arg Asn Ser Asn Ala Gly Val Ser Tyr Ala Lys Tyr Gly Asn His Thr 
65                  70                  75                  80  


Asn His Val Thr Arg Thr Thr Ser Val Asn Lys Ser Ser Thr Asn Val 
                85                  90                  95      


Lys Ser Ser Asn Val Gly Ala Gly Asp Asn Ser Ser Tyr Val Arg Lys 
            100                 105                 110         


Met Asp Ser Gly Gly Val Tyr Asp Ser Asn Asp Gly Gly Ser Asn Val 
        115                 120                 125             


Thr Ser Tyr Tyr Thr Asn Asp Ser Gly Gly Tyr Asn Ser Ser Thr Ser 
    130                 135                 140                 


Ala Asp Ala Ser Ala His His Ala His Gly Tyr Gly Ala Arg Gly Val 
145                 150                 155                 160 


Thr Tyr Lys Thr Lys Val Lys Ala Met Ala Lys Arg Thr Gly Gly Asp 
                165                 170                 175     


Asn Thr Ser Ala Met Lys Lys Tyr Asn Asn Ala Asn Tyr Lys Ala Thr 
            180                 185                 190         


Arg Ser Arg Val Asn Ser Ala Tyr Asp Asn Tyr Lys Asp Tyr Trp Lys 
        195                 200                 205             


Tyr Gly Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val Asn Asn Lys Asn 
    210                 215                 220                 


Tyr Lys Lys Tyr Ser Thr Asp Ala Asn Lys Lys Val Lys Cys Arg Asn 
225                 230                 235                 240 


Thr Tyr Lys Tyr Gly Lys Val Asn Asp Asp Asp Tyr Thr Val Ser Gly 
                245                 250                 255     


Asn Gly Asn Ala Val Asn Asn Arg Gly Asn Lys Asn Lys Asp Ser Asp 
            260                 265                 270         


Lys Gly Val Lys Val Lys Cys Lys Ser Val Arg Lys Gly Thr Lys Ala 
        275                 280                 285             


Arg Cys Arg Val Asn Asn Arg Val Ala Ser Ser Ser Tyr Asn Asn Asp 
    290                 295                 300                 


Asn Thr Lys Asp Asp Thr Thr Asn Asn Asn Asn Tyr Arg Asn Asn Asp 
305                 310                 315                 320 


Val Asp Tyr Asn Ser Thr Ser Asn Thr Asn Thr Val Asp Asp Ser Tyr 
                325                 330                 335     


Val Arg Tyr Asp Ser Asn Gly Thr Ser His Asn Val Val Asp Asn Val 
            340                 345                 350         


Tyr His Ala Lys Val Gly Thr Asn Ser Thr Ser Ser Asp Thr Ala Ser 
        355                 360                 365             


Ser Val Tyr Thr Ser Ser Asn Thr Asn Lys Val His Ala Ala Ser Trp 
    370                 375                 380                 


Asn Val Arg Asp Thr Thr Ala Thr Lys Ser Thr Asp Lys Ala Asp Ser 
385                 390                 395                 400 


Val Val Tyr Val Gly Ala Asn Gly Asn Val Lys Asn Lys Ala Gly Ala 
                405                 410                 415     


Gly Val Thr Val Thr Lys Ser Gly Ser Ser Asn Lys Asn Lys Lys Ala 
            420                 425                 430         


Asn Asn Ser Met Arg Thr Lys Trp Lys Tyr Ser Trp Val Ser Asn Trp 
        435                 440                 445             


Thr Arg Asn Thr Asn Lys Arg Lys Met Tyr Ala Asn Val Asp Ala Lys 
    450                 455                 460                 


Thr Val Tyr Lys Tyr Asn Asn Tyr Thr Ser Asp Arg Asn Arg Ser Tyr 
465                 470                 475                 480 


Asn Asn Asn Arg Asn Lys Lys Val Ser Ala Met Asn Arg Thr Ser Ser 
                485                 490                 495     


Tyr Met Lys Asn Ala Lys Val Ser Lys Arg Tyr Asp Gly Val Lys Tyr 
            500                 505                 510         


Asp Tyr Ser His Arg Ser Gly Asn Ser Val Asn Asp Val Thr Ser Thr 
        515                 520                 525             


Asn Asn Ser Ser Ser Tyr Thr Asn Asp Lys Tyr Asn Lys Tyr Lys Lys 
    530                 535                 540                 


Lys Asp Asn Ser Asp Met Arg Tyr Asn Asn Lys Asp Ser Gly Tyr Gly 
545                 550                 555                 560 


Ser Asn Ser Asn Gly Asp Val Tyr Tyr Ser Thr Asn Arg Asn Gly Tyr 
                565                 570                 575     


Ser Ser Lys Ser Val Asn Ala Asn Asn Asp Tyr Asn Gly Arg Tyr Asn 
            580                 585                 590         


Ser Ser Trp Val Arg Lys Tyr Asn Lys Val Asn Asn Asn Tyr Thr Asp 
        595                 600                 605             


Cys Arg Asn Asn Asn Ser Gly Trp Lys Ser Asn Tyr Asn Lys Trp Thr 
    610                 615                 620                 


Asp Thr Ala Gly Asn Asn Lys Val Asn Tyr Thr Met Ser Ser Asp Tyr 
625                 630                 635                 640 


Asn Lys Trp Val Thr Thr Asn Asn Arg Gly Asn Ser Arg Tyr Asn Gly 
                645                 650                 655     


Asn Asp Lys Ser Ser Asn Gly Asp His Val Ser Asp Asn Lys Val Gly 
            660                 665                 670         


Cys Asn Asp Thr Arg Tyr Val Gly Arg Tyr Lys Val Asp Thr Gly Lys 
        675                 680                 685             


Thr Thr Tyr Ser Asp Asp Ser Lys Asp Trp Gly Asn Tyr Tyr Asn Lys 
    690                 695                 700                 


Arg Tyr Tyr Asn Arg Thr Asp Lys Ser Thr Asn Ser Asn Asn Asn Arg 
705                 710                 715                 720 


Gly Val Tyr Lys Asn Ser Asn Thr Arg Tyr Thr Gly Val Val Arg Lys 
                725                 730                 735     


Asn Gly Ser Thr Asp Ser Asn Thr Asp Asn Val Arg Lys Asn Asp Ala 
            740                 745                 750         


Tyr Asn Val Val Asp Arg Asp Val Tyr Arg Tyr Ala Asp Ser Ala Lys 
        755                 760                 765             


Lys Lys Arg Thr Ser Asn Ser Asn Asn Ser Gly Val Met Asp Ser Gly 
    770                 775                 780                 


Asn Asn Cys Thr Met Asn Asn Asn Asn Gly Gly Asn Gly Gly His Ser 
785                 790                 795                 800 


Asn Asn Val Ala Ser Ser Trp Tyr Tyr Asn Asn Arg Lys Asn Thr Ser 
                805                 810                 815     


Ser Asn Gly Cys Trp Ser Ser Lys His Gly Trp Asn 
            820                 825             


<210>  58
<211>  837
<212>  PRT
<213>  Clostridium botulinum


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  58

Met Val Asn Lys Xaa Asn Tyr Asn Asp Asn Asn Asp Asp Met Met Asn 
1               5                   10                  15      


Asp Gly Gly Thr Tyr Tyr Lys Ala Arg Asp Arg Trp Val Arg Thr Tyr 
            20                  25                  30          


Gly Asp Asn Ala Ser Thr Gly Val Ser Lys Asp Val Tyr Tyr Tyr Asp 
        35                  40                  45              


Thr Tyr Lys Thr Asp Ala Lys Asp Lys Lys Thr Met Lys Asn Arg Asn 
    50                  55                  60                  


Ser Lys Ser Gly Arg Asp Met Val Asp Ala Tyr Gly Asn Ala Ser Thr 
65                  70                  75                  80  


Asp Lys Ala Ala Asn Val Ala Asn Val Ser Asn Lys Lys Gly Ala Asp 
                85                  90                  95      


Lys Gly Met Thr Asn Gly Gly Val Ser Asp Asn Thr Asp Ser Met Met 
            100                 105                 110         


Asn Gly His Ser Ser Gly Gly Ala Arg Met Met Arg Cys Ser Cys Asn 
        115                 120                 125             


Val Asn Asn Val Asn Lys Asp Thr Ser Ser Arg Arg Ala Tyr Ala Asp 
    130                 135                 140                 


Ala Thr Met His His Val His Gly Tyr Gly Lys Ser Asn Thr Asn Thr 
145                 150                 155                 160 


Lys Met His Ser Asp Val Ala Tyr Thr Gly Gly His Asp Ser Val Ser 
                165                 170                 175     


Ser Thr Asp Met Asn Tyr Asn Lys Ala Asn Asp Ala Asn Arg Asn Val 
            180                 185                 190         


Ser Ser Ala Gly Ser Gly Asp Ser Tyr Lys Tyr Lys Asn Lys Tyr Asp 
        195                 200                 205             


Val Asp Asn Gly Lys Tyr Ser Val Asp Lys Asp Lys Asp Lys Tyr Lys 
    210                 215                 220                 


Ala Met Gly Thr Thr Asn Ala Gly Tyr Gly Lys Thr Arg Tyr Ser Tyr 
225                 230                 235                 240 


Ser Tyr Lys Thr Lys Asp Asn Thr Tyr Thr Asn Gly Asn Ala Ser Lys 
                245                 250                 255     


Asn Lys Thr Asn Gly Asn Lys Ala Val Asn Lys Ala Tyr Ser His Val 
            260                 265                 270         


Tyr Arg Ala Met Cys Lys Val Met Tyr Lys Asn Thr Gly Lys Ser Cys 
        275                 280                 285             


Val Asn Asn Asp Ala Asn Lys Asp Ser Ser Lys Asp Ala Lys Ala Thr 
    290                 295                 300                 


Ala Tyr Asn Thr Asn Asn Thr Asn Asn Ser Asp Asp Asn Asp Ser Ser 
305                 310                 315                 320 


Gly Asp Asn Asn Thr Thr Asn Asp Asp Asp Val Tyr Lys Ser Ala Lys 
                325                 330                 335     


Lys Val Asp Gly Asp Ser Tyr His Ala Thr Ser Asn Asn Thr Asn Ser 
            340                 345                 350         


Asn Asp Ala Arg Asn Asn Asn Lys Val Tyr Thr Ser Thr Asn Val Lys 
        355                 360                 365             


Ala Asn Thr Val Val Gly Ala Ser Val Asn Trp Val Lys Gly Val Asp 
    370                 375                 380                 


Asp Thr Ser Ser Thr Lys Ser Thr Asp Lys Val Ser Asp Val Ser Tyr 
385                 390                 395                 400 


Gly Ala Asn Val Gly Asn Thr Ala Lys Asn Lys Asn Ala Gly Gly Ala 
                405                 410                 415     


Ala Met Val Val Gly Thr Ser Tyr Val Gly Asn Lys Gly His Met Thr 
            420                 425                 430         


Ser Asn Ala Lys Lys Arg Asp Lys Trp Thr Asp Met Tyr Gly Val Ser 
        435                 440                 445             


Trp Ser Thr Val Asn Thr Tyr Thr Lys Arg Met Tyr Asn Ala Asn Asn 
    450                 455                 460                 


Ser Ala Lys Asp Tyr Asn Arg Tyr Ser Asp Lys Met Asn Asn Asp Asn 
465                 470                 475                 480 


Asp Asp Lys Asn Ser Asn Ala Asn Asn Asp Asp Asn Cys Ser Ser Tyr 
                485                 490                 495     


Met Asn Arg Met Ala Val Lys Lys Lys Asp Asp Asp Asn Lys Arg Asp 
            500                 505                 510         


Tyr Asp Thr Asn Tyr Asp Val Asn Lys Ser Lys Val Asn Arg His Lys 
        515                 520                 525             


Asp Ser Asp Ser Tyr Thr Lys Asp Thr Val Asn Asn Tyr Ser Asn Ser 
    530                 535                 540                 


Ser Asn Ala Ser Ser Tyr Arg Gly Gly Arg Asp Ser Ser Gly Tyr Gly 
545                 550                 555                 560 


Ala Thr Met Asn Val Gly Ser Asp Val Asn Asp Gly Asn Gly Lys Asn 
                565                 570                 575     


Asn Ser Asn Ser Asn Thr Ala His Ser Lys Val Val Tyr Asp Ser Met 
            580                 585                 590         


Asp Asn Ser Asn Trp Val Arg Thr Lys Tyr Asn Asn Asn Asp Thr Tyr 
        595                 600                 605             


Asn Tyr Thr Ser Cys Lys Asn Asp Ser Gly Trp Lys Val Ser Lys Gly 
    610                 615                 620                 


Asn Arg Trp Thr Asp Val Asn Ala Lys Ser Lys Ser Tyr Ser Lys Asp 
625                 630                 635                 640 


Asn Ser Asp Tyr Asn Lys Trp Ser Thr Thr Asn Asp Arg Gly Asn Ala 
                645                 650                 655     


Asn Tyr Asn Gly Ser Lys Lys Ser Lys Asn Asp Arg Asn Ser Ser Asn 
            660                 665                 670         


Asp Asp Lys Asn Cys Thr Asp Thr Thr Lys Val Trp Lys Asp Asn Gly 
        675                 680                 685             


Arg Asn Ala Thr Val Ser Ser Tyr Trp Ser Ser Thr Asn Thr Lys Asp 
    690                 695                 700                 


Trp Gly Asn Arg Tyr Asp Thr Tyr Tyr Asn Gly Met Asn Tyr Lys Tyr 
705                 710                 715                 720 


Ser Lys Ala Ser Met Gly Thr Ala Arg Thr Asn Asn Asn Ala Ala Asn 
                725                 730                 735     


Tyr Asn Tyr Gly Arg Lys Lys Ala Ser Asn Ser Arg Asn Asn Asn Asp 
            740                 745                 750         


Asn Val Arg Gly Asp Tyr Tyr Asn Asp Asn Ser Asp Ser Tyr Arg Val 
        755                 760                 765             


Tyr Val Val Asn Ser Lys Thr Ala Asn Asp Asp Thr Tyr Asp Val Lys 
    770                 775                 780                 


Lys Tyr Tyr Lys Thr Thr Tyr Asn Cys Cys Lys Asp Thr Lys Thr Gly 
785                 790                 795                 800 


Gly Gly Lys Val Lys Asp Tyr Gly Tyr Val Trp Asp Thr Tyr Asp Asn 
                805                 810                 815     


Tyr Cys Ser Trp Tyr Arg Arg Ser Asn Asn Lys Arg Gly Cys Asn Trp 
            820                 825                 830         


Val Asp Gly Trp Thr 
        835         


<210>  59
<211>  11
<212>  PRT
<213>  Clostridium botulinum

<400>  59

Lys Thr Lys Ser Leu Asp Lys Gly Tyr Asn Lys 
1               5                   10      


<210>  60
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Enterokinase cleavage site

<400>  60

Asp Asp Asp Asp Lys 
1               5   


<210>  61
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  TEV recognition sequence

<400>  61

Glu Asn Leu Tyr Phe Gln 
1               5       


<210>  62
<211>  34
<212>  PRT
<213>  Artificial

<220>
<223>  Signal peptide

<400>  62

Met Pro Met Leu Ser Ala Ile Val Leu Tyr Val Leu Leu Ala Ala Ala 
1               5                   10                  15      


Ala His Ser Ala Phe Ala Ala Met Val His His His His His His Ser 
            20                  25                  30          


Ala Ser 
        


<210>  63
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Spacer

<400>  63

Ala Arg Gly Gly Ala Ser Gly 
1               5           


<210>  64
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Cargo attachment peptide

<400>  64

Gly Asp Ser Leu Ser Trp Leu Leu Arg Leu Leu Asn 
1               5                   10          


<210>  65
<211>  3891
<212>  DNA
<213>  Clostridium botulinum

<400>  65
atgccatttg ttaataaaca atttaattat aaagatcctg taaatggtgt tgatattgct       60

tatataaaaa ttccaaatgc aggacaaatg caaccagtaa aagcttttaa aattcataat      120

aaaatatggg ttattccaga aagagataca tttacaaatc ctgaagaagg agatttaaat      180

ccaccaccag aagcaaaaca agttccagtt tcatattatg attcaacata tttaagtaca      240

gataatgaaa aagataatta tttaaaggga gttacaaaat tatttgagag aatttattca      300

actgatcttg gaagaatgtt gttaacatca atagtaaggg gaataccatt ttggggtgga      360

agtacaatag atacagaatt aaaagttatt gatactaatt gtattaatgt gatacaacca      420

gatggtagtt atagatcaga agaacttaat ctagtaataa taggaccctc agctgatatt      480

atacagtttg aatgtaaaag ctttggacat gaagttttga atcttacgcg aaatggttat      540

ggctctactc aatacattag atttagccca gattttacat ttggttttga ggagtcactt      600

gaagttgata caaatcctct tttaggtgca ggcaaatttg ctacagatcc agcagtaaca      660

ttagcacatg aacttataca tgctggacat agattatatg gaatagcaat taatccaaat      720

agggttttta aagtaaatac taatgcctat tatgaaatga gtgggttaga agtaagcttt      780

gaggaactta gaacatttgg gggacatgat gcaaagttta tagatagttt acaggaaaac      840

gaatttcgtc tatattatta taataagttt aaagatatag caagtacact taataaagct      900

aaatcaatag taggtactac tgcttcatta cagtatatga aaaatgtttt taaagagaaa      960

tatctcctat ctgaagatac atctggaaaa ttttcggtag ataaattaaa atttgataag     1020

ttatacaaaa tgttaacaga gatttacaca gaggataatt ttgttaagtt ttttaaagta     1080

cttaacagaa aaacatattt gaattttgat aaagccgtat ttaagataaa tatagtacct     1140

aaggtaaatt acacaatata tgatggattt aatttaagaa atacaaattt agcagcaaac     1200

tttaatggtc aaaatacaga aattaataat atgaatttta ctaaactaaa aaattttact     1260

ggattgtttg aattttataa gttgctatgt gtaagaggga taataacttc taaaactaaa     1320

tcattagata aaggatacaa taaggcatta aatgatttat gtatcaaagt taataattgg     1380

gacttgtttt ttagtccttc agaagataat tttactaatg atctaaataa aggagaagaa     1440

attacatctg atactaatat agaagcagca gaagaaaata ttagtttaga tttaatacaa     1500

caatattatt taacctttaa ttttgataat gaacctgaaa atatttcaat agaaaatctt     1560

tcaagtgaca ttataggcca attagaactt atgcctaata tagaaagatt tcctaatgga     1620

aaaaagtatg agttagataa atatactatg ttccattatc ttcgtgctca agaatttgaa     1680

catggtaaat ctaggattgc tttaacaaat tctgttaacg aagcattatt aaatcctagt     1740

cgtgtttata catttttttc ttcagactat gtaaagaaag ttaataaagc tacggaggca     1800

gctatgtttt taggctgggt agaacaatta gtatatgatt ttaccgatga aactagcgaa     1860

gtaagtacta cggataaaat tgcggatata actataatta ttccatatat aggacctgct     1920

ttaaatatag gtaatatgtt atataaagat gattttgtag gtgctttaat attttcagga     1980

gctgttattc tgttagaatt tataccagag attgcaatac ctgtattagg tacttttgca     2040

cttgtatcat atattgcgaa taaggttcta accgttcaaa caatagataa tgctttaagt     2100

aaaagaaatg aaaaatggga tgaggtctat aaatatatag taacaaattg gttagcaaag     2160

gttaatacac agattgatct aataagaaaa aaaatgaaag aagctttaga aaatcaagca     2220

gaagcaacaa aggctataat aaactatcag tataatcaat atactgagga agagaaaaat     2280

aatattaatt ttaatattga tgatttaagt tcgaaactta atgagtctat aaataaagct     2340

atgattaata taaataaatt tttgaatcaa tgctctgttt catatttaat gaattctatg     2400

atcccttatg gtgttaaacg gttagaagat tttgatgcta gtcttaaaga tgcattatta     2460

aagtatatat atgataatag aggaacttta attggtcaag tagatagatt aaaagataaa     2520

gttaataata cacttagtac agatatacct tttcagcttt ccaaatacgt agataatcaa     2580

agattattat ctacatttac tgaatatatt aagaatatta ttaatacttc tatattgaat     2640

ttaagatatg aaagtaatca tttaatagac ttatctaggt atgcatcaaa aataaatatt     2700

ggtagtaaag taaattttga tccaatagat aaaaatcaaa ttcaattatt taatttagaa     2760

agtagtaaaa ttgaggtaat tttaaaaaat gctattgtat ataatagtat gtatgaaaat     2820

tttagtacta gcttttggat aagaattcct aagtatttta acagtataag tctaaataat     2880

gaatatacaa taataaattg tatggaaaat aattcaggat ggaaagtatc acttaattat     2940

ggtgaaataa tctggacttt acaggatact caggaaataa aacaaagagt agtttttaaa     3000

tacagtcaaa tgattaatat atcagattat ataaacagat ggatttttgt aactatcact     3060

aataatagat taaataactc taaaatttat ataaatggaa gattaataga tcaaaaacca     3120

atttcaaatt taggtaatat tcatgctagt aataatataa tgtttaaatt agatggttgt     3180

agagatacac atagatatat ttggataaaa tattttaatc tttttgataa ggaattaaat     3240

gaaaaagaaa tcaaagattt atatgataat caatcaaatt caggtatttt aaaagacttt     3300

tggggtgatt atttacaata tgataaacca tactatatgt taaatttata tgatccaaat     3360

aaatatgtcg atgtaaataa tgtaggtatt agaggttata tgtatcttaa agggcctaga     3420

ggtagcgtaa tgactacaaa catttattta aattcaagtt tgtatagggg gacaaaattt     3480

attataaaaa aatatgcttc tggaaataaa gataatattg ttagaaataa tgatcgtgta     3540

tatattaatg tagtagttaa aaataaagaa tataggttag ctactaatgc atcacaggca     3600

ggcgtagaaa aaatactaag tgcattagaa atacctgatg taggaaatct aagtcaagta     3660

gtagtaatga agtcaaaaaa tgatcaagga ataacaaata aatgcaaaat gaatttacaa     3720

gataataatg ggaatgatat aggctttata ggatttcatc agtttaataa tatagctaaa     3780

ctagtagcaa gtaattggta taatagacaa atagaaagat ctagtaggac tttgggttgc     3840

tcatgggaat ttattcctgt agatgatgga tggggagaaa ggccactgta a              3891


<210>  66
<211>  4051
<212>  DNA
<213>  Clostridium botulinum

<400>  66
gataataata atataataat gatgacaata tacctaaagc tgcacattta tggacattaa       60

aagggatata aacttaaaat aaggaggaga atatttatgc cagttacaat aaataatttt      120

aattataatg atcctattga taatgacaat attattatga tggaacctcc atttgcaagg      180

ggtacgggga gatattataa agcttttaaa atcacagatc gtatttggat aatacccgaa      240

agatatactt ttggatataa acctgaggat tttaataaaa gttccggtat ttttaataga      300

gatgtttgtg aatattatga tccagattac ttaaatacca atgataaaaa gaatatattt      360

ttccaaacat tgatcaagtt atttaataga atcaaatcaa aaccattggg tgaaaagtta      420

ttagagatga ttataaatgg tataccttat cttggagata gacgtgttcc actcgaagag      480

tttaacacaa acattgctag tgtaactgtt aataaattaa ttagtaatcc aggagaagtg      540

gagcgaaaaa aaggtatttt cgcaaattta ataatatttg gacctgggcc agttttaaat      600

gaaaatgaga ctatagatat aggtatacaa aatcattttg catcaaggga aggctttggg      660

ggtataatgc aaatgaaatt ttgtccagaa tatgtaagcg tatttaataa tgttcaagaa      720

aacaaaggcg caagtatatt taatagacgt ggatattttt cagatccagc cttgatatta      780

atgcatgaac ttatacatgt tttgcatgga ttatatggca ttaaagtaga tgatttacca      840

attgtaccaa atgaaaaaaa attttttatg caatctacag atactataca ggcagaagaa      900

ctatatacat ttggaggaca agatcccagc atcatatctc cttctacaga taaaagtatc      960

tatgataaag ttttgcaaaa ttttaggggg atagttgata gacttaacaa ggttttagtt     1020

tgcatatcag atcctaacat taacattaat atatataaaa ataaatttaa agataaatat     1080

aaattcgttg aagattctga aggaaaatat agtatagatg tagaaagttt caataaatta     1140

tataaaagct taatgttagg ttttacagaa attaatatag cagaaaatta taaaataaaa     1200

actagagctt cttattttag tgattcctta ccaccagtaa aaataaaaaa tttattagat     1260

aatgaaatct atactataga ggaagggttt aatatatctg ataaaaatat gggaaaagaa     1320

tataggggtc agaataaagc tataaataaa caagcttatg aagaaatcag caaggagcat     1380

ttggctgtat ataagataca aatgtgtaaa agtgttaaag ttccaggaat atgtattgat     1440

gtcgataatg aaaatttgtt ctttatagct gataaaaata gtttttcaga tgatttatct     1500

aaaaatgaaa gagtagaata taatacacag aataattata taggaaatga ctttcctata     1560

aatgaattaa ttttagatac tgatttaata agtaaaatag aattaccaag tgaaaataca     1620

gaatcactta ctgattttaa tgtagatgtt ccagtatatg aaaaacaacc cgctataaaa     1680

aaagttttta cagatgaaaa taccatcttt caatatttat actctcagac atttcctcta     1740

aatataagag atataagttt aacatcttca tttgatgatg cattattagt ttctagcaaa     1800

gtttattcat ttttttctat ggattatatt aaaactgcta ataaagtagt agaagcagga     1860

ttatttgcag gttgggtgaa acagatagta gatgattttg taatcgaagc taataaaagc     1920

agtactatgg ataaaattgc agatatatct ctaattgttc cttatatagg attagcttta     1980

aatgtaggag atgaaacagc taaaggaaat tttgaaagtg cttttgagat tgcaggatcc     2040

agtattttac tagaatttat accagaactt ttaatacctg tagttggagt ctttttatta     2100

gaatcatata ttgacaataa aaataaaatt attaaaacaa tagataatgc tttaactaaa     2160

agagtggaaa aatggattga tatgtacgga ttaatagtag cgcaatggct ctcaacagtt     2220

aatactcaat tttatacaat aaaagaggga atgtataagg ctttaaatta tcaagcacaa     2280

gcattggaag aaataataaa atacaaatat aatatatatt ctgaagagga aaagtcaaat     2340

attaacatca attttaatga tataaattct aaacttaatg atggtattaa ccaagctatg     2400

gataatataa atgattttat aaatgaatgt tctgtatcat atttaatgaa aaaaatgatt     2460

ccattagctg taaaaaaatt actagacttt gataatactc tcaaaaaaaa tttattaaat     2520

tatatagatg aaaataaatt atatttaatt ggaagtgtag aagatgaaaa atcaaaagta     2580

gataaatact tgaaaaccat tataccattt gatctttcaa cgtattctaa tattgaaata     2640

ctaataaaaa tatttaataa atataatagc gaaattttaa ataatattat cttaaattta     2700

agatatagag ataataattt aatagattta tcaggatatg gagcaaaggt agaggtatat     2760

gatggggtca agcttaatga taaaaatcaa tttaaattaa ctagttcagc agatagtaag     2820

attagagtca ctcaaaatca gaatattata tttaatagta tgttccttga ttttagcgtt     2880

agcttttgga taaggatacc taaatatagg aatgatgata tacaaaatta tattcataat     2940

gaatatacga taattaattg tatgaaaaat aattcaggct ggaaaatatc tattaggggt     3000

aataggataa tatggacctt aattgatata aatggaaaaa ccaaatcagt attttttgaa     3060

tataacataa gagaagatat atcagagtat ataaatagat ggttttttgt aactattact     3120

aataatttgg ataatgctaa aatttatatt aatggcacgt tagaatcaaa tatggatatt     3180

aaagatatag gagaagttat tgttaatggt gaaataacat ttaaattaga tggtgatgta     3240

gatagaacac aatttatttg gatgaaatat tttagtattt ttaatacgca attaaatcaa     3300

tcaaatatta aagagatata taaaattcaa tcatatagcg aatacttaaa agatttttgg     3360

ggaaatcctt taatgtataa taaagaatat tatatgttta atgcggggaa taaaaattca     3420

tatattaaac tagtgaaaga ttcatctgta ggtgaaatat taatacgtag caaatataat     3480

cagaattcca attatataaa ttatagaaat ttatatattg gagaaaaatt tattataaga     3540

agagagtcaa attctcaatc tataaatgat gatatagtta gaaaagaaga ttatatacat     3600

ctagatttgg tacttcacca tgaagagtgg agagtatatg cctataaata ttttaaggaa     3660

caggaagaaa aattgttttt atctattata agtgattcta atgaatttta taagactata     3720

gaaataaaag aatatgatga acagccatca tatagttgtc agttgctttt taaaaaagat     3780

gaagaaagta ctgatgatat aggattgatt ggtattcatc gtttctacga atctggagtt     3840

ttacgtaaaa agtataaaga ttatttttgt ataagtaaat ggtacttaaa agaggtaaaa     3900

aggaaaccat ataagtcaaa tttgggatgt aattggcagt ttattcctaa agatgaaggg     3960

tggactgaat aatataacta tatgctcagc aaacctattt tatataagaa aagtttaagt     4020

ttataaaatc ttaagtttaa ggatgtagct a                                    4051


<210>  67
<211>  3994
<212>  DNA
<213>  Clostridium botulinum

<400>  67
tatgatatgt aatgacaata acaaggtgcc taaaggtgca catttgtgga tattagaaag       60

ttaggagatg ttagtattat gccaataaca attaacaact ttaattattc agatcctgtt      120

gataataaaa atattttata tttagatact catttaaata cactagctaa tgagcctgaa      180

aaagcctttc gcattacagg aaatatatgg gtaatacctg atagattttc aagaaattct      240

aatccaaatt taaataaacc tcctcgagtt acaagcccta aaagtggtta ttatgatcct      300

aattatttga gtactgattc tgacaaagat acatttttaa aagaaattat aaagttattt      360

aaaagaatta attctagaga aataggagaa gaattaatat atagactttc gacagatata      420

ccctttcctg ggaataacaa tactccaatt aatacttttg attttgatgt agattttaac      480

agtgttgatg ttaaaactag acaaggtaac aactgggtta aaactggtag cataaatcct      540

agtgttataa taactggacc tagagaaaac attatagatc cagaaacttc tacgtttaaa      600

ttaactaaca atacttttgc ggcacaagaa ggatttggtg ctttatcaat aatttcaata      660

tcacctagat ttatgctaac atatagtaat gcaactaatg atgtaggaga gggtagattt      720

tctaagtctg aattttgcat ggatccaata ctaattttaa tgcatgaact taatcatgca      780

atgcataatt tatatggaat agctatacca aatgatcaaa caatttcatc tgtaactagt      840

aatatttttt attctcaata taatgtgaaa ttagagtatg cagaaatata tgcatttgga      900

ggtccaacta tagaccttat tcctaaaagt gcaaggaaat attttgagga aaaggcattg      960

gattattata gatctatagc taaaagactt aatagtataa ctactgcaaa tccttcaagc     1020

tttaataaat atatagggga atataaacag aaacttatta gaaagtatag attcgtagta     1080

gaatcttcag gtgaagttac agtaaatcgt aataagtttg ttgagttata taatgaactt     1140

acacaaatat ttacagaatt taactacgct aaaatatata atgtacaaaa taggaaaata     1200

tatctttcaa atgtatatac tccggttacg gcaaatatat tagacgataa tgtttatgat     1260

atacaaaatg gatttaatat acctaaaagt aatttaaatg tactatttat gggtcaaaat     1320

ttatctcgaa atccagcatt aagaaaagtc aatcctgaaa atatgcttta tttatttaca     1380

aaattttgtc ataaagcaat agatggtaga tcattatata ataaaacatt agattgtaga     1440

gagcttttag ttaaaaatac tgacttaccc tttataggtg atattagtga tgttaaaact     1500

gatatatttt taagaaaaga tattaatgaa gaaactgaag ttatatacta tccggacaat     1560

gtttcagtag atcaagttat tctcagtaag aatacctcag aacatggaca actagattta     1620

ttatacccta gtattgacag tgagagtgaa atattaccag gggagaatca agtcttttat     1680

gataatagaa ctcaaaatgt tgattatttg aattcttatt attacctaga atctcaaaaa     1740

ctaagtgata atgttgaaga ttttactttt acgagatcaa ttgaggaggc tttggataat     1800

agtgcaaaag tatatactta ctttcctaca ctagctaata aagtaaatgc gggtgttcaa     1860

ggtggtttat ttttaatgtg ggcaaatgat gtagttgaag attttactac aaatattcta     1920

agaaaagata cattagataa aatatcagat gtatcagcta ttattcccta tataggaccc     1980

gcattaaata taagtaattc tgtaagaaga ggaaatttta ctgaagcatt tgcagttact     2040

ggtgtaacta ttttattaga agcatttcct gaatttacaa tacctgcact tggtgcattt     2100

gtgatttata gtaaggttca agaaagaaac gagattatta aaactataga taattgttta     2160

gaacaaagga ttaagagatg gaaagattca tatgaatgga tgatgggaac gtggttatcc     2220

aggattatta ctcaatttaa taatataagt tatcaaatgt atgattcttt aaattatcag     2280

gcaggtgcaa tcaaagctaa aatagattta gaatataaaa aatattcagg aagtgataaa     2340

gaaaatataa aaagtcaagt tgaaaattta aaaaatagtt tagatgtaaa aatttcggaa     2400

gcaatgaata atataaataa atttatacga gaatgttccg taacatattt atttaaaaat     2460

atgttaccta aagtaattga tgaattaaat gagtttgatc gaaatactaa agcaaaatta     2520

attaatctta tagatagtca taatattatt ctagttggtg aagtagataa attaaaagca     2580

aaagtaaata atagctttca aaatacaata ccctttaata ttttttcata tactaataat     2640

tctttattaa aagatataat taatgaatat ttcaataata ttaatgattc aaaaattttg     2700

agcctacaaa acagaaaaaa tactttagtg gatacatcag gatataatgc agaagtgagt     2760

gaagaaggcg atgttcagct taatccaata tttccatttg actttaaatt aggtagttca     2820

ggggaggata gaggtaaagt tatagtaacc cagaatgaaa atattgtata taattctatg     2880

tatgaaagtt ttagcattag tttttggatt agaataaata aatgggtaag taatttacct     2940

ggatatacta taattgatag tgttaaaaat aactcaggtt ggagtatagg tattattagt     3000

aattttttag tatttacttt aaaacaaaat gaagatagtg aacaaagtat aaattttagt     3060

tatgatatat caaataatgc tcctggatac aataaatggt tttttgtaac tgttactaac     3120

aatatgatgg gaaatatgaa gatttatata aatggaaaat taatagatac tataaaagtt     3180

aaagaactaa ctggaattaa ttttagcaaa actataacat ttgaaataaa taaaattcca     3240

gataccggtt tgattacttc agattctgat aacatcaata tgtggataag agatttttat     3300

atatttgcta aagaattaga tggtaaagat attaatatat tatttaatag cttgcaatat     3360

actaatgttg taaaagatta ttggggaaat gatttaagat ataataaaga atattatatg     3420

gttaatatag attatttaaa tagatatatg tatgcgaact cacgacaaat tgtttttaat     3480

acacgtagaa ataataatga cttcaatgaa ggatataaaa ttataataaa aagaatcaga     3540

ggaaatacaa atgatactag agtacgagga ggagatattt tatattttga tatgacaatt     3600

aataacaaag catataattt gtttatgaag aatgaaacta tgtatgcaga taatcatagt     3660

actgaagata tatatgctat aggtttaaga gaacaaacaa aggatataaa tgataatatt     3720

atatttcaaa tacaaccaat gaataatact tattattacg catctcaaat atttaaatca     3780

aattttaatg gagaaaatat ttctggaata tgttcaatag gtacttatcg ttttagactt     3840

ggaggtgatt ggtatagaca caattatttg gtgcctactg tgaagcaagg aaattatgct     3900

tcattattag aatcaacatc aactcattgg ggttttgtac ctgtaagtga ataaataatg     3960

attaataata taaattatgt taaatatttt aata                                 3994


<210>  68
<211>  3952
<212>  DNA
<213>  Clostridium botulinum

<400>  68
aaggtgcaca cttgtggata ttagaaagtt aggagatgtt agtattatga catggccagt       60

aaaagatttt aattatagtg atcctgttaa tgacaatgat atattatatt taagaatacc      120

acaaaataag ttaattacta cacctgtaaa agcttttatg attactcaaa atatttgggt      180

aataccagaa agattttcat cagatactaa tccaagttta agtaaaccgc ccagacctac      240

ttcaaagtat caaagttatt atgatcctag ttatttatct actgatgaac aaaaagatac      300

atttttaaaa gggattataa aattatttaa aagaattaat gaaagagata taggaaaaaa      360

attaataaat tatttagtag ttggttcacc ttttatggga gattcaagta cgcctgaaga      420

tacatttgat tttacacgtc atactactaa tattgcagtt gaaaagtttg aaaatggtag      480

ttggaaagta acaaatatta taacaccaag tgtattgata tttggaccac ttcctaatat      540

attagactat acagcatccc ttacattgca aggacaacaa tcaaatccat catttgaagg      600

gtttggaaca ttatctatac taaaagtagc acctgaattt ttgttaacat ttagtgatgt      660

aacatctaat caaagttcag ctgtattagg caaatctata ttttgtatgg atccagtaat      720

agctttaatg catgagttaa cacattcttt gcatcaatta tatggaataa atataccatc      780

tgataaaagg attcgtccac aagttagcga gggatttttc tctcaagatg gacccaacgt      840

acaatttgag gaattatata catttggagg attagatgtt gaaataatac ctcaaattga      900

aagatcacaa ttaagagaaa aagcattagg tcactataaa gatatagcga aaagacttaa      960

taatattaat aaaactattc cttctagttg gattagtaat atagataaat ataaaaaaat     1020

attttctgaa aagtataatt ttgataaaga taatacagga aattttgttg taaatattga     1080

taaattcaat agcttatatt cagacttgac taatgttatg tcagaagttg tttattcttc     1140

gcaatataat gttaaaaaca ggactcatta tttttcaagg cattatctac ctgtatttgc     1200

aaatatatta gatgataata tttatactat aagagatggt tttaatttaa caaataaagg     1260

ttttaatata gaaaattcgg gtcagaatat agaaaggaat cctgcactac aaaagcttag     1320

ttcagaaagt gtagtagatt tatttacaaa agtatgttta agattaacaa aaaatagtag     1380

agatgattca acatgtatta aagttaaaaa taatagatta ccttatgtag ctgataaaga     1440

tagcatttca caagaaatat ttgaaaataa aattattaca gatgagacta atgtacaaaa     1500

ttattcagat aaattttcat tagatgaatc tattttagat gggcaagttc ctattaatcc     1560

tgaaatagta gatccactat tacccaatgt taatatggaa cctttaaatc ttccaggtga     1620

agaaatagta ttttatgatg atattactaa atatgttgat tatttaaatt cttattatta     1680

tttggaatct caaaaattaa gtaataatgt tgaaaatatt actcttacaa cttcagttga     1740

agaagcatta ggttatagca ataagatata cacattttta cctagcttag ctgaaaaagt     1800

gaataaaggt gttcaagcag gtttattctt aaattgggcg aatgaagtag ttgaggattt     1860

tactacaaat attatgaaga aagatacatt ggataaaata tcagatgtat cagtaataat     1920

tccatatata ggacctgcct taaatatagg aaattcagca ttaaggggaa attttaatca     1980

agcatttgca acagctggtg tagctttttt attagaggga tttccagagt ttactatacc     2040

tgcactcggt gtatttacct tttatagttc tattcaagaa agagagaaaa ttattaaaac     2100

tatagaaaat tgtttggaac aaagagttaa gagatggaaa gattcatatc aatggatggt     2160

atcaaattgg ttgtcaagaa ttactactca atttaatcat ataaattatc aaatgtatga     2220

ttctttaagt tatcaggcag atgcaatcaa agctaaaata gatttagaat ataaaaaata     2280

ctcaggaagt gataaagaaa atataaaaag tcaagttgaa aatttaaaaa atagtttaga     2340

tgtaaaaatt tcggaagcaa tgaataatat aaataaattt atacgagaat gttctgtaac     2400

atacttattt aaaaatatgc tccctaaagt aattgacgaa ttaaataagt ttgatttaag     2460

aactaaaaca gaattaatta atcttataga tagtcataat attattctag ttggtgaagt     2520

agatagatta aaagcaaaag taaatgagag ttttgaaaat acaatgcctt ttaatatttt     2580

ttcatatact aataattctt tattaaaaga tataattaat gaatatttca atagtattaa     2640

tgattcaaaa attttgagct tacaaaacaa aaaaaatgct ttagtggata catcaggata     2700

taatgcagaa gtgagggtag gagataatgt tcaacttaat acgatatata caaatgactt     2760

taaattaagt agttcaggag ataaaattat agtaaattta aataataata ttttatatag     2820

cgctatttat gagaactcta gtgttagttt ttggattaag atatctaaag atttaactaa     2880

ttctcataat gaatatacaa taattaacag tatagaacaa aattctgggt ggaaattatg     2940

tattaggaat ggcaatatag aatggatttt acaagatgtt aatagaaagt ataaaagttt     3000

aatttttgat tatagtgaat cattaagtca tacaggatat acaaataaat ggttttttgt     3060

tactataact aataatataa tggggtatat gaaactttat ataaatggag aattaaagca     3120

gagtcaaaaa attgaagatt tagatgaggt taagttagat aaaaccatag tatttggaat     3180

agatgagaat atagatgaga atcagatgct ttggattaga gattttaata ttttttctaa     3240

agaattaagt aatgaagata ttaatattgt atatgaggga caaatattaa gaaatgttat     3300

taaagattat tggggaaatc ctttgaagtt tgatacagaa tattatatta ttaatgataa     3360

ttatatagat aggtatatag cacctgaaag taatgtactt gtacttgttc agtatccaga     3420

tagatctaaa ttatatactg gaaatcctat tactattaaa tcagtatctg ataagaatcc     3480

ttatagtaga attttaaatg gagataatat aattcttcat atgttatata atagtaggaa     3540

atatatgata ataagagata ctgatacaat atatgcaaca caaggaggag agtgttcaca     3600

aaattgtgta tatgcattaa aattacagag taatttaggt aattatggta taggtatatt     3660

tagtataaaa aatattgtat ctaaaaataa atattgtagt caaattttct ctagttttag     3720

ggaaaataca atgcttctag cagatatata taaaccttgg agattttctt ttaaaaatgc     3780

atacacgcca gttgcagtaa ctaattatga aacaaaacta ttatcaactt catctttttg     3840

gaaatttatt tctagggatc caggatgggt agagtaatac aataaaaatt taatataaac     3900

tattaaatta tattacaagt tttagaaatt tatcgtataa aatgttgaat tc             3952


<210>  69
<211>  3759
<212>  DNA
<213>  Clostridium botulinum

<400>  69
atgccaaaaa ttaatagttt taattataat gatcctgtta atgatagaac aattttatat       60

attaaaccag gcggttgtca agaattttat aaatcattta atattatgaa aaatatttgg      120

ataattccag agagaaatgt aattggtaca accccccaag attttcatcc gcctacttca      180

ttaaaaaatg gagatagtag ttattatgac cctaattatt tacaaagtga tgaagaaaag      240

gatagatttt taaaaatagt cacaaaaata tttaatagaa taaataataa tctttcagga      300

gggattttat tagaagaact gtcaaaagct aatccatatt tagggaatga taatactcca      360

gataatcaat tccatattgg tgatgcatca gcagttgaga ttaaattctc aaatggtagc      420

caagacatac tattacctaa tgttattata atgggagcag agcctgattt atttgaaact      480

aacagttcca atatttctct aagaaataat tatatgccaa gcaatcacgg ttttggatca      540

atagctatag taacattctc acctgaatat tcttttagat ttaatgataa tagtatgaat      600

gaatttattc aagatcctgc tcttacatta atgcatgaat taatacattc attacatgga      660

ctatatgggg ctaaagggat tactacaaag tatactataa cacaaaaaca aaatccccta      720

ataacaaata taagaggtac aaatattgaa gaattcttaa cttttggagg tactgattta      780

aacattatta ctagtgctca gtccaatgat atctatacta atcttctagc tgattataaa      840

aaaatagcgt ctaaacttag caaagtacaa gtatctaatc cactacttaa tccttataaa      900

gatgtttttg aagcaaagta tggattagat aaagatgcta gcggaattta ttcggtaaat      960

ataaacaaat ttaatgatat ttttaaaaaa ttatacagct ttacggaatt tgatttagca     1020

actaaatttc aagttaaatg taggcaaact tatattggac agtataaata cttcaaactt     1080

tcaaacttgt taaatgattc tatttataat atatcagaag gctataatat aaataattta     1140

aaggtaaatt ttagaggaca gaatgcaaat ttaaatccta gaattattac accaattaca     1200

ggtagaggac tagtaaaaaa aatcattaga ttttgtaaaa atattgtttc tgtaaaaggc     1260

ataaggaaat caatatgtat cgaaataaat aatggtgagt tattttttgt ggcttccgag     1320

aatagttata atgatgataa tataaatact cctaaagaaa ttgacgatac agtaacttca     1380

aataataatt atgaaaatga tttagatcag gttattttaa attttaatag tgaatcagca     1440

cctggacttt cagatgaaaa attaaattta actatccaaa atgatgctta tataccaaaa     1500

tatgattcta atggaacaag tgatatagaa caacatgatg ttaatgaact taatgtattt     1560

ttctatttag atgcacagaa agtgcccgaa ggtgaaaata atgtcaatct cacctcttca     1620

attgatacag cattattaga acaacctaaa atatatacat ttttttcatc agaatttatt     1680

aataatgtca ataaacctgt gcaagcagca ttatttgtaa gctggataca acaagtgtta     1740

gtagatttta ctactgaagc taaccaaaaa agtactgttg ataaaattgc agatatttct     1800

atagttgttc catatatagg tcttgcttta aatataggaa atgaagcaca aaaaggaaat     1860

tttaaagatg cacttgaatt attaggagca ggtattttat tagaatttga acccgagctt     1920

ttaattccta caattttagt attcacgata aaatcttttt taggttcatc tgataataaa     1980

aataaagtta ttaaagcaat aaataatgca ttgaaagaaa gagatgaaaa atggaaagaa     2040

gtatatagtt ttatagtatc gaattggatg actaaaatta atacacaatt taataaaaga     2100

aaagaacaaa tgtatcaagc tttacaaaat caagtaaatg caattaaaac aataatagaa     2160

tctaagtata atagttatac tttagaggaa aaaaatgagc ttacaaataa atatgatatt     2220

aagcaaatag aaaatgaact taatcaaaag gtttctatag caatgaataa tatagacagg     2280

ttcttaactg aaagttctat atcctattta atgaaattaa taaatgaagt aaaaattaat     2340

aaattaagag aatatgatga gaatgtcaaa acgtatttat tgaattatat tatacaacat     2400

ggatcaatct tgggagagag tcagcaagaa ctaaattcta tggtaactga taccctaaat     2460

aatagtattc cttttaagct ttcttcttat acagatgata aaattttaat ttcatatttt     2520

aataaattct ttaagagaat taaaagtagt tcagttttaa atatgagata taaaaatgat     2580

aaatacgtag atacttcagg atatgattca aatataaata ttaatggaga tgtatataaa     2640

tatccaacta ataaaaatca atttggaata tataatgata aacttagtga agttaatata     2700

tctcaaaatg attacattat atatgataat aaatataaaa attttagtat tagtttttgg     2760

gtaagaattc ctaactatga taataagata gtaaatgtta ataatgaata cactataata     2820

aattgtatga gagataataa ttcaggatgg aaagtatctc ttaatcataa tgaaataatt     2880

tggacattgc aagataatgc aggaattaat caaaaattag catttaacta tggtaacgca     2940

aatggtattt ctgattatat aaataagtgg atttttgtaa ctataactaa tgatagatta     3000

ggagattcta aactttatat taatggaaat ttaatagatc aaaaatcaat tttaaattta     3060

ggtaatattc atgttagtga caatatatta tttaaaatag ttaattgtag ttatacaaga     3120

tatattggta ttagatattt taatattttt gataaagaat tagatgaaac agaaattcaa     3180

actttatata gcaatgaacc taatacaaat attttgaagg atttttgggg aaattatttg     3240

ctttatgaca aagaatacta tttattaaat gtgttaaaac caaataactt tattgatagg     3300

agaaaagatt ctactttaag cattaataat ataagaagca ctattctttt agctaataga     3360

ttatatagtg gaataaaagt taaaatacaa agagttaata atagtagtac taacgataat     3420

cttgttagaa agaatgatca ggtatatatt aattttgtag ccagcaaaac tcacttattt     3480

ccattatatg ctgatacagc taccacaaat aaagagaaaa caataaaaat atcatcatct     3540

ggcaatagat ttaatcaagt agtagttatg aattcagtag gaaataattg tacaatgaat     3600

tttaaaaata ataatggaaa taatattggg ttgttaggtt tcaaggcaga tactgtagtt     3660

gctagtactt ggtattatac acatatgaga gatcatacaa acagcaatgg atgtttttgg     3720

aactttattt ctgaagaaca tggatggcaa gaaaaataa                            3759


<210>  70
<211>  4209
<212>  DNA
<213>  Clostridium botulinum

<400>  70
aaatggcgca aagaagatga taattagtaa taatatattt atttccaatt gtttaactct       60

atcttgtggc ggtaaatata tatgtttatc tatgaaagat gaaaactata attggatgat      120

atgtaataat gaaagcaaca tacctaaaaa ggcatattta tggacattga aagaagtata      180

ggggggattt tatgccagtt gtaataaata gttttaatta taatgaccct gttaatgatg      240

atacaatttt atacatgcag ataccatatg aagaaaaaag taaaaaatat tataaagctt      300

ttgagattat gcgtaatgtt tggataattc ctgagagaaa tacaatagga acggatccta      360

gtgattttga tccaccggct tcattagaga acggaagcag tgcttattat gatcctaatt      420

atttaaccac tgatgctgaa aaagatagat atttaaaaac aacgataaaa ttatttaaga      480

gaattaatag taatcctgca ggggaagttt tgttacaaga aatatcatat gctaaaccat      540

atttaggaaa tgaacacacg ccaattaatg aattccatcc agttactaga actacaagtg      600

ttaatataaa atcatcaact aatgttaaaa gttcaataat attgaatctt cttgtattgg      660

gagcaggacc tgatatattt gaaaattctt cttaccccgt tagaaaacta atggattcag      720

gtggagttta tgacccaagt aatgatggtt ttggatcaat taatatcgtg acattttcac      780

ctgaatatga atatactttt aatgatatta gtggagggta taacagtagt acagaatcat      840

ttattgcaga tcctgcaatt tcactagctc atgaattgat acatgcactg catggattat      900

acggggctag gggagttact tataaagaga ctataaaagt aaagcaagca cctcttatga      960

tagccgaaaa acccataagg ctagaagaat ttttaacctt tggaggtcag gatttaaata     1020

ttattactag tgctatgaag gaaaaaatat ataacaatct tttagctaac tatgaaaaaa     1080

tagctactag acttagtaga gttaatagtg ctcctcctga atatgatatt aatgaatata     1140

aagattattt tcaatggaag tatgggctag ataaaaatgc tgatggaagt tatactgtaa     1200

atgaaaataa atttaatgaa atttataaaa aattatatag ctttacagag attgacttag     1260

caaataaatt taaagtaaaa tgtagaaata cttattttat taaatatgga tttttaaaag     1320

ttccaaattt gttagatgat gatatttata ctgtatcaga ggggtttaat ataggtaatt     1380

tagcagtaaa caatcgcgga caaaatataa agttaaatcc taaaattatt gattccattc     1440

cagataaagg tctagtggaa aagatcgtta aattttgtaa gagcgttatt cctagaaaag     1500

gtacaaaggc gccaccgcga ctatgcatta gagtaaataa tagggagtta ttttttgtag     1560

cttcagaaag tagctataat gaaaatgata ttaatacacc taaagaaatt gacgatacaa     1620

caaatctaaa taataattat agaaataatt tagatgaagt tattttagat tataatagtg     1680

agacaatacc tcaaatatca aatcaaacat taaatacact tgtacaagac gatagttatg     1740

tgccaagata tgattctaat ggaacaagtg aaatagagga acataatgtt gttgacctta     1800

atgtattttt ctatttacat gcacaaaaag taccagaagg tgaaactaat ataagtttaa     1860

cttcttcaat tgatacggca ttatcagaag aatcgcaagt atatacattc ttttcttcag     1920

agtttattaa tactatcaat aaacctgtac acgcagcact atttataagt tggataaatc     1980

aagtaataag agattttact actgaagcta cacaaaaaag tacttttgat aagattgcag     2040

acatatcttt agttgtacca tatgtaggtc ttgctttaaa tataggtaat gaggtacaaa     2100

aagaaaattt taaggaggca tttgaattat taggagcggg tattttatta gaatttgtgc     2160

cagagctttt aattcctaca attttagtgt ttacaataaa atcctttata ggttcatctg     2220

agaataaaaa taaaatcatt aaagcaataa ataattcatt aatggaaaga gaaacaaagt     2280

ggaaagaaat atatagttgg atagtatcaa attggcttac tagaattaat acacaattta     2340

ataaaagaaa agaacaaatg tatcaagctt tgcaaaatca agtagatgca ataaaaacag     2400

taatagaata taaatataat aattatactt cagatgagag aaatagactt gaatctgaat     2460

ataatatcaa taatataaga gaagaattga acaaaaaagt ttctttagca atggaaaata     2520

tagagagatt tataacagag agttctatat tttatttaat gaagttaata aatgaagcca     2580

aagttagtaa attaagagaa tatgatgaag gcgttaagga atatttgcta gactatattt     2640

cagaacatag atcaatttta ggaaatagtg tacaagaatt aaatgattta gtgactagta     2700

ctctgaataa tagtattcca tttgaacttt cttcatatac taatgataaa attctaattt     2760

tatattttaa taaattatat aaaaaaatta aagataactc tattttagat atgcgatatg     2820

aaaataataa atttatagat atctctggat atggttcaaa tataagcatt aatggagatg     2880

tatatattta ttcaacaaat agaaatcaat ttggaatata tagtagtaag cctagtgaag     2940

ttaatatagc tcaaaataat gatattatat acaatggtag atatcaaaat tttagtatta     3000

gtttctgggt aaggattcct aaatacttca ataaagtgaa tcttaataat gaatatacta     3060

taatagattg tataaggaat aataattcag gatggaaaat atcacttaat tataataaaa     3120

taatttggac tttacaagat actgctggaa ataatcaaaa actagttttt aattatacac     3180

aaatgattag tatatctgat tatataaata aatggatttt tgtaactatt actaataata     3240

gattaggcaa ttctagaatt tacatcaatg gaaatttaat agatgaaaaa tcaatttcga     3300

atttaggtga tattcatgtt agtgataata tattatttaa aattgttggt tgtaatgata     3360

caagatatgt tggtataaga tattttaaag tttttgatac ggaattaggt aaaacagaaa     3420

ttgagacttt atatagtgat gagccagatc caagtatctt aaaagacttt tggggaaatt     3480

atttgttata taataaaaga tattatttat tgaatttact aagaacagat aagtctatta     3540

ctcagaattc aaactttcta aatattaatc aacaaagagg tgtttatcag aaaccaaata     3600

ttttttccaa cactagatta tatacaggag tagaagttat tataagaaaa aatggatcta     3660

cagatatatc taatacagat aattttgtta gaaaaaatga tctggcatat attaatgtag     3720

tagatcgtga tgtagaatat cggctatatg ctgatatatc aattgcaaaa ccagagaaaa     3780

taataaaatt aataagaaca tctaattcaa acaatagctt aggtcaaatt atagttatgg     3840

attcaatagg aaataattgc acaatgaatt ttcaaaacaa taatgggggc aatataggat     3900

tactaggttt tcattcaaat aatttggttg ctagtagttg gtattataac aatatacgaa     3960

aaaatactag cagtaatgga tgcttttgga gttttatttc taaagagcat ggatggcaag     4020

aaaactaata taataattca aaaaataggt attaaaatag aggtaatata tattaccctc     4080

tattttggaa taattttaat atattatatg aaacatatat aaatttaaag ataatattaa     4140

atcaagacac aaattcaaat tagaaatata aaatgaagta aatgaaaagt gtaaaaagtc     4200

attaaataa                                                             4209


<210>  71
<211>  3937
<212>  DNA
<213>  Clostridium botulinum


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is a, c, g, or t

<400>  71
atgccagtta atataaaaan ctttaattat aatgacccta ttaataatga tgacattatt       60

atgatggaac cattcaatga cccagggcca ggaacatatt ataaagcttt taggattata      120

gatcgtattt ggatagtacc agaaaggttt acttatggat ttcaacctga ccaatttaat      180

gccagtacag gagtttttag taaagatgtc tacgaatatt acgatccaac ttatttaaaa      240

accgatgctg aaaaagataa atttttaaaa acaatgatta aattatttaa tagaattaat      300

tcaaaaccat caggacagag attactggat atgatagtag atgctatacc ttatcttgga      360

aatgcatcta caccgcccga caaatttgca gcaaatgttg caaatgtatc tattaataaa      420

aaaattatcc aacctggagc tgaagatcaa ataaaaggtt taatgacaaa tttaataata      480

tttggaccag gaccagttct aagtgataat tttactgata gtatgattat gaatggccat      540

tccccaatat cagaaggatt tggtgcaaga atgatgataa gattttgtcc tagttgttta      600

aatgtattta ataatgttca ggaaaataaa gatacatcta tatttagtag acgcgcgtat      660

tttgcagatc cagctctaac gttaatgcat gaacttatac atgtgttaca tggattatat      720

ggaattaaga taagtaattt accaattact ccaaatacaa aagaattttt catgcaacat      780

agcgatcctg tacaagcaga agaactatat acattcggag gacatgatcc tagtgttata      840

agtccttcta cggatatgaa tatttataat aaagcgttac aaaattttca agatatagct      900

aataggctta atattgtttc aagtgcccaa gggagtggaa ttgatatttc cttatataaa      960

caaatatata aaaataaata tgattttgtt gaagatccta atggaaaata tagtgtagat     1020

aaggataagt ttgataaatt atataaggcc ttaatgtttg gctttactga aactaatcta     1080

gctggtgaat atggaataaa aactaggtat tcttatttta gtgaatattt gccaccgata     1140

aaaactgaaa aattgttaga caatacaatt tatactcaaa atgaaggctt taacatagct     1200

agtaaaaatc tcaaaacgga atttaatggt cagaataagg cggtaaataa agaggcttat     1260

gaagaaatca gcctagaaca tctcgttata tatagaatag caatgtgcaa gcctgtaatg     1320

tacaaaaata ccggtaaatc tgaacagtgt attattgtta ataatgagga tttatttttc     1380

atagctaata aagatagttt ttcaaaagat ttagctaaag cagaaactat agcatataat     1440

acacaaaata atactataga aaataatttt tctatagatc agttgatttt agataatgat     1500

ttaagcagtg gcatagactt accaaatgaa aacacagaac catttacaaa ttttgacgac     1560

atagatatcc ctgtgtatat taaacaatct gctttaaaaa aaatttttgt ggatggagat     1620

agcctttttg aatatttaca tgctcaaaca tttccttcta atatagaaaa tctacaacta     1680

acgaattcat taaatgatgc tttaagaaat aataataaag tctatacttt tttttctaca     1740

aaccttgttg aaaaagctaa tacagttgta ggtgcttcac tttttgtaaa ctgggtaaaa     1800

ggagtaatag atgattttac atctgaatcc acacaaaaaa gtactataga taaagtttca     1860

gatgtatcca taattattcc ctatatagga cctgctttga atgtaggaaa tgaaacagct     1920

aaagaaaatt ttaaaaatgc ttttgaaata ggtggagccg ctatcttaat ggagtttatt     1980

ccagaactta ttgtacctat agttggattt tttacattag aatcatatgt aggaaataaa     2040

gggcatatta ttatgacgat atccaatgct ttaaagaaaa gggatcaaaa atggacagat     2100

atgtatggtt tgatagtatc gcagtggctc tcaacggtta atactcaatt ttatacaata     2160

aaagaaagaa tgtacaatgc tttaaataat caatcacaag caatagaaaa aataatagaa     2220

gatcaatata atagatatag tgaagaagat aaaatgaata ttaacattga ttttaatgat     2280

atagatttta aacttaatca aagtataaat ttagcaataa acaatataga tgattttata     2340

aaccaatgtt ctatatcata tctaatgaat agaatgattc cattagctgt aaaaaagtta     2400

aaagactttg atgataatct taagagagat ttattggagt atatagatac aaatgaacta     2460

tatttacttg atgaagtaaa tattctaaaa tcaaaagtaa atagacacct aaaagacagt     2520

ataccatttg atctttcact atataccaag gacacaattt taatacaagt ttttaataat     2580

tatattagta atattagtag taatgctatt ttaagtttaa gttatagagg tgggcgttta     2640

atagattcat ctggatatgg tgcaactatg aatgtaggtt cagatgttat ctttaatgat     2700

ataggaaatg gtcaatttaa attaaataat tctgaaaata gtaatattac ggcacatcaa     2760

agtaaattcg ttgtatatga tagtatgttt gataatttta gcattaactt ttgggtaagg     2820

actcctaaat ataataataa tgatatacaa acttatcttc aaaatgagta tacaataatt     2880

agttgtataa aaaatgactc aggatggaaa gtatctatta agggaaatag aataatatgg     2940

acattaatag atgttaatgc aaaatctaaa tcaatatttt tcgaatatag tataaaagat     3000

aatatatcag attatataaa taaatggttt tccataacta ttactaatga tagattaggt     3060

aacgcaaata tttatataaa tggaagtttg aaaaaaagtg aaaaaatttt aaacttagat     3120

agaattaatt ctagtaatga tatagacttc aaattaatta attgtacaga tactactaaa     3180

tttgtttgga ttaaggattt taatattttt ggtagagaat taaatgctac agaagtatct     3240

tcactatatt ggattcaatc atctacaaat actttaaaag atttttgggg gaatccttta     3300

agatacgata cacaatacta tctgtttaat caaggtatgc aaaatatcta tataaagtat     3360

tttagtaaag cttctatggg ggaaactgca ccacgtacaa actttaataa tgcagcaata     3420

aattatcaaa atttatatct tggtttacga tttattataa aaaaagcatc aaattctcgg     3480

aatataaata atgataatat agtcagagaa ggagattata tatatcttaa tattgataat     3540

atttctgatg aatcttacag agtatatgtt ttggtgaatt ctaaagaaat tcaaactcaa     3600

ttatttttag cacccataaa tgatgatcct acgttctatg atgtactaca aataaaaaaa     3660

tattatgaaa aaacaacata taattgtcag atactttgcg aaaaagatac taaaacattt     3720

gggctgtttg gaattggtaa atttgttaaa gattatggat atgtttggga tacctatgat     3780

aattattttt gcataagtca gtggtatctc agaagaatat ctgaaaatat aaataaatta     3840

aggttgggat gtaattggca attcattccc gtggatgaag gatggacaga ataatataat     3900

taaatattta ttaaagctac tttgatagga aaatcaa                              3937


