                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  Methods For Upregulating Immune Responses Using Combinations Of 
       Anti-RGMb And Anti-PD-1 Agents

<130>  DFS-149.25

<140>  PCT/US2015/064203
<141>  2015-12-07

<150>  62/088,855
<151>  2014-12-08

<160>  10  

<170>  PatentIn version 3.5

<210>  1
<211>  921
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (25)..(888)

<400>  1
cactctggtg gggctgctcc aggc atg cag atc cca cag gcg ccc tgg cca          51
                           Met Gln Ile Pro Gln Ala Pro Trp Pro            
                           1               5                              

gtc gtc tgg gcg gtg cta caa ctg ggc tgg cgg cca gga tgg ttc tta         99
Val Val Trp Ala Val Leu Gln Leu Gly Trp Arg Pro Gly Trp Phe Leu           
10                  15                  20                  25            

gac tcc cca gac agg ccc tgg aac ccc ccc acc ttc tcc cca gcc ctg        147
Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu           
                30                  35                  40                

ctc gtg gtg acc gaa ggg gac aac gcc acc ttc acc tgc agc ttc tcc        195
Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser           
            45                  50                  55                    

aac aca tcg gag agc ttc gtg cta aac tgg tac cgc atg agc ccc agc        243
Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser           
        60                  65                  70                        

aac cag acg gac aag ctg gcc gcc ttc ccc gag gac cgc agc cag ccc        291
Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro           
    75                  80                  85                            

ggc cag gac tgc cgc ttc cgt gtc aca caa ctg ccc aac ggg cgt gac        339
Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp           
90                  95                  100                 105           

ttc cac atg agc gtg gtc agg gcc cgg cgc aat gac agc ggc acc tac        387
Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr           
                110                 115                 120               

ctc tgt ggg gcc atc tcc ctg gcc ccc aag gcg cag atc aaa gag agc        435
Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser           
            125                 130                 135                   

ctg cgg gca gag ctc agg gtg aca gag aga agg gca gaa gtg ccc aca        483
Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr           
        140                 145                 150                       

gcc cac ccc agc ccc tca ccc agg tca gcc ggc cag ttc caa acc ctg        531
Ala His Pro Ser Pro Ser Pro Arg Ser Ala Gly Gln Phe Gln Thr Leu           
    155                 160                 165                           

gtg gtt ggt gtc gtg ggc ggc ctg ctg ggc agc ctg gtg ctg cta gtc        579
Val Val Gly Val Val Gly Gly Leu Leu Gly Ser Leu Val Leu Leu Val           
170                 175                 180                 185           

tgg gtc ctg gcc gtc atc tgc tcc cgg gcc gca cga ggg aca ata gga        627
Trp Val Leu Ala Val Ile Cys Ser Arg Ala Ala Arg Gly Thr Ile Gly           
                190                 195                 200               

gcc agg cgc acc ggc cag ccc ctg aag gag gac ccc tca gcc gtg cct        675
Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val Pro           
            205                 210                 215                   

gtg ttc tct gtg gac tat ggg gag ctg gat ttc cag tgg cga gag aag        723
Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys           
        220                 225                 230                       

acc ccg gag ccc ccc gtg ccc tgt gtc cct gag cag acg gag tat gcc        771
Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala           
    235                 240                 245                           

acc att gtc ttt cct agc gga atg ggc acc tca tcc ccc gcc cgc agg        819
Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg Arg           
250                 255                 260                 265           

ggc tca gct gac ggc cct cgg agt gcc cag cca ctg agg cct gag gat        867
Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp           
                270                 275                 280               

gga cac tgc tct tgg ccc ctc tgaccggctt ccttggccac cagtgttctg cag       921
Gly His Cys Ser Trp Pro Leu                                               
            285                                                           


<210>  2
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Ser Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  3
<211>  968
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (59)..(793)

<400>  3
gcttcccgag gctccgcacc agccgcgctt ctgtccgcct gcagggcatt ccagaaag         58

atg agg ata ttt gct gtc ttt ata ttc atg acc tac tgg cat ttg ctg        106
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu           
1               5                   10                  15                

aac gca ttt act gtc acg gtt ccc aag gac cta tat gtg gta gag tat        154
Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr           
            20                  25                  30                    

ggt agc aat atg aca att gaa tgc aaa ttc cca gta gaa aaa caa tta        202
Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu           
        35                  40                  45                        

gac ctg gct gca cta att gtc tat tgg gaa atg gag gat aag aac att        250
Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile           
    50                  55                  60                            

att caa ttt gtg cat gga gag gaa gac ctg aag gtt cag cat agt agc        298
Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser           
65                  70                  75                  80            

tac aga cag agg gcc cgg ctg ttg aag gac cag ctc tcc ctg gga aat        346
Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn           
                85                  90                  95                

gct gca ctt cag atc aca gat gtg aaa ttg cag gat gca ggg gtg tac        394
Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr           
            100                 105                 110                   

cgc tgc atg atc agc tat ggt ggt gcc gac tac aag cga att act gtg        442
Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val           
        115                 120                 125                       

aaa gtc aat gcc cca tac aac aaa atc aac caa aga att ttg gtt gtg        490
Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val           
    130                 135                 140                           

gat cca gtc acc tct gaa cat gaa ctg aca tgt cag gct gag ggc tac        538
Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr           
145                 150                 155                 160           

ccc aag gcc gaa gtc atc tgg aca agc agt gac cat caa gtc ctg agt        586
Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser           
                165                 170                 175               

ggt aag acc acc acc acc aat tcc aag aga gag gag aag ctt ttc aat        634
Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn           
            180                 185                 190                   

gtg acc agc aca ctg aga atc aac aca aca act aat gag att ttc tac        682
Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr           
        195                 200                 205                       

tgc act ttt agg aga tta gat cct gag gaa aac cat aca gct gaa ttg        730
Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu           
    210                 215                 220                           

gtc atc cca ggt aat att ctg aat gtg tcc att aaa ata tgt cta aca        778
Val Ile Pro Gly Asn Ile Leu Asn Val Ser Ile Lys Ile Cys Leu Thr           
225                 230                 235                 240           

ctg tcc cct agc acc tagcatgatg tctgcctatc atagtcattc agtgattgtt        833
Leu Ser Pro Ser Thr                                                       
                245                                                       

gaataaatga atgaatgaat aacactatgt ttacaaaata tatcctaatt cctcacctcc      893

attcatccaa accatattgt tacttaataa acattcagca gatatttatg gaataaaaaa      953

aaaaaaaaaa aaaaa                                                       968


<210>  4
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Gly Asn Ile Leu Asn Val Ser Ile Lys Ile Cys Leu Thr 
225                 230                 235                 240 


Leu Ser Pro Ser Thr 
                245 


<210>  5
<211>  1553
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (53)..(922)

<400>  5
cgaggctccg caccagccgc gcttctgtcc gcctgcaggg cattccagaa ag atg agg       58
                                                          Met Arg         
                                                          1               

ata ttt gct gtc ttt ata ttc atg acc tac tgg cat ttg ctg aac gca        106
Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu Asn Ala           
        5                   10                  15                        

ttt act gtc acg gtt ccc aag gac cta tat gtg gta gag tat ggt agc        154
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser           
    20                  25                  30                            

aat atg aca att gaa tgc aaa ttc cca gta gaa aaa caa tta gac ctg        202
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu           
35                  40                  45                  50            

gct gca cta att gtc tat tgg gaa atg gag gat aag aac att att caa        250
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln           
                55                  60                  65                

ttt gtg cat gga gag gaa gac ctg aag gtt cag cat agt agc tac aga        298
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg           
            70                  75                  80                    

cag agg gcc cgg ctg ttg aag gac cag ctc tcc ctg gga aat gct gca        346
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala           
        85                  90                  95                        

ctt cag atc aca gat gtg aaa ttg cag gat gca ggg gtg tac cgc tgc        394
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys           
    100                 105                 110                           

atg atc agc tat ggt ggt gcc gac tac aag cga att act gtg aaa gtc        442
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val           
115                 120                 125                 130           

aat gcc cca tac aac aaa atc aac caa aga att ttg gtt gtg gat cca        490
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro           
                135                 140                 145               

gtc acc tct gaa cat gaa ctg aca tgt cag gct gag ggc tac ccc aag        538
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys           
            150                 155                 160                   

gcc gaa gtc atc tgg aca agc agt gac cat caa gtc ctg agt ggt aag        586
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys           
        165                 170                 175                       

acc acc acc acc aat tcc aag aga gag gag aag ctt ttc aat gtg acc        634
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr           
    180                 185                 190                           

agc aca ctg aga atc aac aca aca act aat gag att ttc tac tgc act        682
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr           
195                 200                 205                 210           

ttt agg aga tta gat cct gag gaa aac cat aca gct gaa ttg gtc atc        730
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile           
                215                 220                 225               

cca gaa cta cct ctg gca cat cct cca aat gaa agg act cac ttg gta        778
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His Leu Val           
            230                 235                 240                   

att ctg gga gcc atc tta tta tgc ctt ggt gta gca ctg aca ttc atc        826
Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr Phe Ile           
        245                 250                 255                       

ttc cgt tta aga aaa ggg aga atg atg gat gtg aaa aaa tgt ggc atc        874
Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys Gly Ile           
    260                 265                 270                           

caa gat aca aac tca aag aag caa agt gat aca cat ttg gag gag acg        922
Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu Glu Thr           
275                 280                 285                 290           

taatccagca ttggaacttc tgatcttcaa gcagggattc tcaacctgtg gtttaggggt      982

tcatcggggc tgagcgtgac aagaggaagg aatgggcccg tgggatgcag gcaatgtggg     1042

acttaaaagg cccaagcact gaaaatggaa cctggcgaaa gcagaggagg agaatgaaga     1102

aagatggagt caaacaggga gcctggaggg agaccttgat actttcaaat gcctgagggg     1162

ctcatcgacg cctgtgacag ggagaaagga tacttctgaa caaggagcct ccaagcaaat     1222

catccattgc tcatcctagg aagacgggtt gagaatccct aatttgaggg tcagttcctg     1282

cagaagtgcc ctttgcctcc actcaatgcc tcaatttgtt ttctgcatga ctgagagtct     1342

cagtgttgga acgggacagt atttatgtat gagtttttcc tatttatttt gagtctgtga     1402

ggtcttcttg tcatgtgagt gtggttgtga atgatttctt ttgaagatat attgtagtag     1462

atgttacaat tttgtcgcca aactaaactt gctgcttaat gatttgctca catctagtaa     1522

aacatggagt atttgtaaaa aaaaaaaaaa a                                    1553


<210>  6
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  7
<211>  819
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(819)

<400>  7
atg atc ttc ctc ctg cta atg ttg agc ctg gaa ttg cag ctt cac cag         48
Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln           
1               5                   10                  15                

ata gca gct tta ttc aca gtg aca gtc cct aag gaa ctg tac ata ata         96
Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile           
            20                  25                  30                    

gag cat ggc agc aat gtg acc ctg gaa tgc aac ttt gac act gga agt        144
Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser           
        35                  40                  45                        

cat gtg aac ctt gga gca ata aca gcc agt ttg caa aag gtg gaa aat        192
His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn           
    50                  55                  60                            

gat aca tcc cca cac cgt gaa aga gcc act ttg ctg gag gag cag ctg        240
Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu           
65                  70                  75                  80            

ccc cta ggg aag gcc tcg ttc cac ata cct caa gtc caa gtg agg gac        288
Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp           
                85                  90                  95                

gaa gga cag tac caa tgc ata atc atc tat ggg gtc gcc tgg gac tac        336
Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr           
            100                 105                 110                   

aag tac ctg act ctg aaa gtc aaa gct tcc tac agg aaa ata aac act        384
Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr           
        115                 120                 125                       

cac atc cta aag gtt cca gaa aca gat gag gta gag ctc acc tgc cag        432
His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln           
    130                 135                 140                           

gct aca ggt tat cct ctg gca gaa gta tcc tgg cca aac gtc agc gtt        480
Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val           
145                 150                 155                 160           

cct gcc aac acc agc cac tcc agg acc cct gaa ggc ctc tac cag gtc        528
Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val           
                165                 170                 175               

acc agt gtt ctg cgc cta aag cca ccc cct ggc aga aac ttc agc tgt        576
Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys           
            180                 185                 190                   

gtg ttc tgg aat act cac gtg agg gaa ctt act ttg gcc agc att gac        624
Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp           
        195                 200                 205                       

ctt caa agt cag atg gaa ccc agg acc cat cca act tgg ctg ctt cac        672
Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Trp Leu Leu His           
    210                 215                 220                           

att ttc atc ccc tcc tgc atc att gct ttc att ttc ata gcc aca gtg        720
Ile Phe Ile Pro Ser Cys Ile Ile Ala Phe Ile Phe Ile Ala Thr Val           
225                 230                 235                 240           

ata gcc cta aga aaa caa ctc tgt caa aag ctg tat tct tca aaa gac        768
Ile Ala Leu Arg Lys Gln Leu Cys Gln Lys Leu Tyr Ser Ser Lys Asp           
                245                 250                 255               

aca aca aaa aga cct gtc acc aca aca aag agg gaa gtg aac agt gct        816
Thr Thr Lys Arg Pro Val Thr Thr Thr Lys Arg Glu Val Asn Ser Ala           
            260                 265                 270                   

atc                                                                    819
Ile                                                                       
                                                                          


<210>  8
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln 
1               5                   10                  15      


Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
            20                  25                  30          


Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
        35                  40                  45              


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp 
                85                  90                  95      


Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr 
        115                 120                 125             


His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln 
    130                 135                 140                 


Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys 
            180                 185                 190         


Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp 
        195                 200                 205             


Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Trp Leu Leu His 
    210                 215                 220                 


Ile Phe Ile Pro Ser Cys Ile Ile Ala Phe Ile Phe Ile Ala Thr Val 
225                 230                 235                 240 


Ile Ala Leu Arg Lys Gln Leu Cys Gln Lys Leu Tyr Ser Ser Lys Asp 
                245                 250                 255     


Thr Thr Lys Arg Pro Val Thr Thr Thr Lys Arg Glu Val Asn Ser Ala 
            260                 265                 270         


Ile 
    

<210>  9
<211>  1437
<212>  DNA
<213>  Homo sapiens

<400>  9
atgataagga agaagaggaa gcgaagcgcg ccccccggcc catgccgcag ccacgggccc       60

agacccgcca cggcgcccgc gccgccgccc tcgccggagc ccacgagacc tgcatggacg      120

ggcatgggct tgagagcagc accttccagc gccgccgctg ccgccgccga ggttgagcag      180

cgccgcagcc ccgggctctg ccccccgccg ctggagctgc tgctgctgct gctgttcagc      240

ctcgggctgc tccacgcagg tgactgccaa cagccagccc aatgtcgaat ccagaaatgc      300

accacggact tcgtgtccct gacttctcac ctgaactctg ccgttgacgg ctttgactct      360

gagttttgca aggccttgcg tgcctatgct ggctgcaccc agcgaacttc aaaagcctgc      420

cgtggcaacc tggtatacca ttctgccgtg ttgggtatca gtgacctcat gagccagagg      480

aattgttcca aggatggacc cacatcctct accaaccccg aagtgaccca tgatccttgc      540

aactatcaca gccacgctgg agccagggaa cacaggagag gggaccagaa ccctcccagt      600

tacctttttt gtggcttgtt tggagatcct cacctcagaa ctttcaagga taacttccaa      660

acatgcaaag tagaaggggc ctggccactc atagataata attatctttc agttcaagtg      720

acaaacgtac ctgtggtccc tggatccagt gctactgcta caaataagat cactattatc      780

ttcaaagccc accatgagtg tacagatcag aaagtctacc aagctgtgac agatgacctg      840

ccggccgcct ttgtggatgg caccaccagt ggtggggaca gcgatgccaa gagcctgcgt      900

atcgtggaaa gggagagtgg ccactatgtg gagatgcacg cccgctatat agggaccaca      960

gtgtttgtgc ggcaggtggg tcgctacctg acccttgcca tccgtatgcc tgaagacctg     1020

gccatgtcct acgaggagag ccaggacctg cagctgtgcg tgaacggctg ccccctgagt     1080

gaacgcatcg atgacgggca gggccaggtg tctgccatcc tgggacacag cctgcctcgc     1140

acctccttgg tgcaggcctg gcctggctac acactggaga ctgccaacac tcaatgccat     1200

gagaagatgc cagtgaagga catctatttc cagtcctgtg tcttcgacct gctcaccact     1260

ggtgatgcca actttactgc cgcagcccac agtgccttgg aggatgtgga ggccctgcac     1320

ccaaggaagg aacgctggca cattttcccc agcagtggca atgggactcc ccgtggaggc     1380

agtgatttgt ctgtcagtct aggactcacc tgcttgatcc ttatcgtgtt tttgtag        1437


<210>  10
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ile Arg Lys Lys Arg Lys Arg Ser Ala Pro Pro Gly Pro Cys Arg 
1               5                   10                  15      


Ser His Gly Pro Arg Pro Ala Thr Ala Pro Ala Pro Pro Pro Ser Pro 
            20                  25                  30          


Glu Pro Thr Arg Pro Ala Trp Thr Gly Met Gly Leu Arg Ala Ala Pro 
        35                  40                  45              


Ser Ser Ala Ala Ala Ala Ala Ala Glu Val Glu Gln Arg Arg Ser Pro 
    50                  55                  60                  


Gly Leu Cys Pro Pro Pro Leu Glu Leu Leu Leu Leu Leu Leu Phe Ser 
65                  70                  75                  80  


Leu Gly Leu Leu His Ala Gly Asp Cys Gln Gln Pro Ala Gln Cys Arg 
                85                  90                  95      


Ile Gln Lys Cys Thr Thr Asp Phe Val Ser Leu Thr Ser His Leu Asn 
            100                 105                 110         


Ser Ala Val Asp Gly Phe Asp Ser Glu Phe Cys Lys Ala Leu Arg Ala 
        115                 120                 125             


Tyr Ala Gly Cys Thr Gln Arg Thr Ser Lys Ala Cys Arg Gly Asn Leu 
    130                 135                 140                 


Val Tyr His Ser Ala Val Leu Gly Ile Ser Asp Leu Met Ser Gln Arg 
145                 150                 155                 160 


Asn Cys Ser Lys Asp Gly Pro Thr Ser Ser Thr Asn Pro Glu Val Thr 
                165                 170                 175     


His Asp Pro Cys Asn Tyr His Ser His Ala Gly Ala Arg Glu His Arg 
            180                 185                 190         


Arg Gly Asp Gln Asn Pro Pro Ser Tyr Leu Phe Cys Gly Leu Phe Gly 
        195                 200                 205             


Asp Pro His Leu Arg Thr Phe Lys Asp Asn Phe Gln Thr Cys Lys Val 
    210                 215                 220                 


Glu Gly Ala Trp Pro Leu Ile Asp Asn Asn Tyr Leu Ser Val Gln Val 
225                 230                 235                 240 


Thr Asn Val Pro Val Val Pro Gly Ser Ser Ala Thr Ala Thr Asn Lys 
                245                 250                 255     


Ile Thr Ile Ile Phe Lys Ala His His Glu Cys Thr Asp Gln Lys Val 
            260                 265                 270         


Tyr Gln Ala Val Thr Asp Asp Leu Pro Ala Ala Phe Val Asp Gly Thr 
        275                 280                 285             


Thr Ser Gly Gly Asp Ser Asp Ala Lys Ser Leu Arg Ile Val Glu Arg 
    290                 295                 300                 


Glu Ser Gly His Tyr Val Glu Met His Ala Arg Tyr Ile Gly Thr Thr 
305                 310                 315                 320 


Val Phe Val Arg Gln Val Gly Arg Tyr Leu Thr Leu Ala Ile Arg Met 
                325                 330                 335     


Pro Glu Asp Leu Ala Met Ser Tyr Glu Glu Ser Gln Asp Leu Gln Leu 
            340                 345                 350         


Cys Val Asn Gly Cys Pro Leu Ser Glu Arg Ile Asp Asp Gly Gln Gly 
        355                 360                 365             


Gln Val Ser Ala Ile Leu Gly His Ser Leu Pro Arg Thr Ser Leu Val 
    370                 375                 380                 


Gln Ala Trp Pro Gly Tyr Thr Leu Glu Thr Ala Asn Thr Gln Cys His 
385                 390                 395                 400 


Glu Lys Met Pro Val Lys Asp Ile Tyr Phe Gln Ser Cys Val Phe Asp 
                405                 410                 415     


Leu Leu Thr Thr Gly Asp Ala Asn Phe Thr Ala Ala Ala His Ser Ala 
            420                 425                 430         


Leu Glu Asp Val Glu Ala Leu His Pro Arg Lys Glu Arg Trp His Ile 
        435                 440                 445             


Phe Pro Ser Ser Gly Asn Gly Thr Pro Arg Gly Gly Ser Asp Leu Ser 
    450                 455                 460                 


Val Ser Leu Gly Leu Thr Cys Leu Ile Leu Ile Val Phe Leu 
465                 470                 475