                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  ANTI-CD70 CHIMERIC ANTIGEN RECEPTORS

<130>  720305

<150>  US 62/088,882
<151>  2014-12-08

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
            20                  25                  30          


Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 
        35                  40                  45              


Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 
    50                  55                  60                  


Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 
65                  70                  75                  80  


Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 
                85                  90                  95      


Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu 
            100                 105                 110         


Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
        115                 120                 125             


Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 
    130                 135                 140                 


Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro 
145                 150                 155                 160 


Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu 
                165                 170                 175     


Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg 
            180                 185                 190         


Pro 
    


<210>  2
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
    210                 215                 220                 


Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu 
225                 230                 235                 240 


Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
                245                 250                 255     


Ala Cys Ser Pro 
            260 


<210>  3
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu 
    210     


<210>  4
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  4

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  5
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  5

Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
1               5                   10                  15      


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
            20                  25                  30          


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40                  45          


<210>  6
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  6

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  7
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
    210                 215                 220                 


Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu 
225                 230                 235                 240 


Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
                245                 250                 255     


Ala Cys Ser Pro Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            260                 265                 270         


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        275                 280                 285             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    290                 295                 300                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
305                 310                 315                 320 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                325                 330                 335     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            340                 345                 350         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        355                 360                 365             


Leu Pro Pro Arg 
    370         


<210>  8
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
    210                 215                 220                 


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
225                 230                 235                 240 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
                245                 250                 255     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
            260                 265                 270         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        275                 280                 285             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
    290                 295                 300                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
305                 310                 315                 320 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                325                 330                 335     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            340                 345                 350         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 


<210>  9
<211>  370
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu 
    210                 215                 220                 


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
225                 230                 235                 240 


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
                245                 250                 255     


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
            260                 265                 270         


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
        275                 280                 285             


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
    290                 295                 300                 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
305                 310                 315                 320 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
                325                 330                 335     


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
            340                 345                 350         


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
        355                 360                 365             


Pro Arg 
    370 


<210>  10
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
    210                 215                 220                 


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
225                 230                 235                 240 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Phe Ser Val 
                245                 250                 255     


Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            260                 265                 270         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        275                 280                 285             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    290                 295                 300                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
305                 310                 315                 320 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                325                 330                 335     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            340                 345                 350         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        355                 360                 365             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    370                 375                 380                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
385                 390                 395                 400 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                405                 410     


<210>  11
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
    210                 215                 220                 


Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu 
225                 230                 235                 240 


Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
                245                 250                 255     


Ala Cys Ser Pro Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
            260                 265                 270         


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
        275                 280                 285             


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys 
    290                 295                 300                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
305                 310                 315                 320 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                325                 330                 335     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            340                 345                 350         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        355                 360                 365             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    370                 375                 380                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
385                 390                 395                 400 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                405                 410             


<210>  12
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
    210                 215                 220                 


Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu 
225                 230                 235                 240 


Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
                245                 250                 255     


Ala Cys Ser Pro Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu 
            260                 265                 270         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        275                 280                 285             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    290                 295                 300                 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
305                 310                 315                 320 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                325                 330                 335     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            340                 345                 350         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        355                 360                 365             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    370                 375                 380                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
385                 390                 395                 400 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                405                 410                 415     


Pro Pro Arg 
            


<210>  13
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
    210                 215                 220                 


Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu 
225                 230                 235                 240 


Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
                245                 250                 255     


Ala Cys Ser Pro Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
            260                 265                 270         


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
        275                 280                 285             


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Phe Ser 
    290                 295                 300                 


Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
305                 310                 315                 320 


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
                325                 330                 335     


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
            340                 345                 350         


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
        355                 360                 365             


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
    370                 375                 380                 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
385                 390                 395                 400 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
                405                 410                 415     


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
            420                 425                 430         


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
        435                 440                 445             


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460 


<210>  14
<211>  1119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
atggcacggc cacatccctg gtggctgtgc gttctgggga ccctggtggg gctctcagct       60

actccagccc ccaagagctg cccagagagg cactactggg ctcagggaaa gctgtgctgc      120

cagatgtgtg agccaggaac attcctcgtg aaggactgtg accagcatag aaaggctgct      180

cagtgtgatc cttgcatacc gggggtctcc ttctctcctg accaccacac ccggccccac      240

tgtgagagct gtcggcactg taactctggt cttctcgttc gcaactgcac catcactgcc      300

aatgctgagt gtgcctgtcg caatggctgg cagtgcaggg acaaggagtg caccgagtgt      360

gatcctcttc caaacccttc gctgaccgct cggtcgtctc aggccctgag cccacaccct      420

cagcccaccc acttacctta tgtcagtgag atgctggagg ccaggacagc tgggcacatg      480

cagactctgg ctgacttcag gcagctgcct gcccggactc tctctaccca ctggccaccc      540

caaagatccc tgtgcagctc cgattttatt cgcatccttg tgatcttctc tggaatgttc      600

cttgttttca ccctggccgg ggccctgttc ctccatcaac gaaggaaata tagatcaaac      660

aaaggagaaa gtcctgtgga gcctgcagag ccttgtcgtt acagctgccc cagggaggag      720

gagggcagca ccatccccat ccaggaggat taccgaaaac cggagcctgc ctgctccccc      780

agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc      840

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      900

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      960

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1020

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1080

tacgacgccc ttcacatgca ggccctgccc cctcgctaa                            1119


<210>  15
<211>  1095
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
atggcacggc cacatccctg gtggctgtgc gttctgggga ccctggtggg gctctcagct       60

actccagccc ccaagagctg cccagagagg cactactggg ctcagggaaa gctgtgctgc      120

cagatgtgtg agccaggaac attcctcgtg aaggactgtg accagcatag aaaggctgct      180

cagtgtgatc cttgcatacc gggggtctcc ttctctcctg accaccacac ccggccccac      240

tgtgagagct gtcggcactg taactctggt cttctcgttc gcaactgcac catcactgcc      300

aatgctgagt gtgcctgtcg caatggctgg cagtgcaggg acaaggagtg caccgagtgt      360

gatcctcttc caaacccttc gctgaccgct cggtcgtctc aggccctgag cccacaccct      420

cagcccaccc acttacctta tgtcagtgag atgctggagg ccaggacagc tgggcacatg      480

cagactctgg ctgacttcag gcagctgcct gcccggactc tctctaccca ctggccaccc      540

caaagatccc tgtgcagctc cgattttatt cgcatccttg tgatcttctc tggaatgttc      600

cttgttttca ccctggccgg ggccctgttc ctcaggagta agaggagcag gctcctgcac      660

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc      720

tatgccccac cacgcgactt cgcagcctat cgctccagag tgaagttcag caggagcgca      780

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga      840

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag      900

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg      960

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1020

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1080

ctgccccctc gctaa                                                      1095


<210>  16
<211>  1113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
atggcacggc cacatccctg gtggctgtgc gttctgggga ccctggtggg gctctcagct       60

actccagccc ccaagagctg cccagagagg cactactggg ctcagggaaa gctgtgctgc      120

cagatgtgtg agccaggaac attcctcgtg aaggactgtg accagcatag aaaggctgct      180

cagtgtgatc cttgcatacc gggggtctcc ttctctcctg accaccacac ccggccccac      240

tgtgagagct gtcggcactg taactctggt cttctcgttc gcaactgcac catcactgcc      300

aatgctgagt gtgcctgtcg caatggctgg cagtgcaggg acaaggagtg caccgagtgt      360

gatcctcttc caaacccttc gctgaccgct cggtcgtctc aggccctgag cccacaccct      420

cagcccaccc acttacctta tgtcagtgag atgctggagg ccaggacagc tgggcacatg      480

cagactctgg ctgacttcag gcagctgcct gcccggactc tctctaccca ctggccaccc      540

caaagatccc tgtgcagctc cgattttatt cgcatccttg tgatcttctc tggaatgttc      600

cttgttttca ccctggccgg ggccctgttc ctccgtttct ctgttgttaa acggggcaga      660

aagaagctcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag      720

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg      780

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac      840

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac      900

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg      960

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1020

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1080

gcccttcaca tgcaggccct gccccctcgc taa                                  1113


<210>  17
<211>  1236
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
atggcacggc cacatccctg gtggctgtgc gttctgggga ccctggtggg gctctcagct       60

actccagccc ccaagagctg cccagagagg cactactggg ctcagggaaa gctgtgctgc      120

cagatgtgtg agccaggaac attcctcgtg aaggactgtg accagcatag aaaggctgct      180

cagtgtgatc cttgcatacc gggggtctcc ttctctcctg accaccacac ccggccccac      240

tgtgagagct gtcggcactg taactctggt cttctcgttc gcaactgcac catcactgcc      300

aatgctgagt gtgcctgtcg caatggctgg cagtgcaggg acaaggagtg caccgagtgt      360

gatcctcttc caaacccttc gctgaccgct cggtcgtctc aggccctgag cccacaccct      420

cagcccaccc acttacctta tgtcagtgag atgctggagg ccaggacagc tgggcacatg      480

cagactctgg ctgacttcag gcagctgcct gcccggactc tctctaccca ctggccaccc      540

caaagatccc tgtgcagctc cgattttatt cgcatccttg tgatcttctc tggaatgttc      600

cttgttttca ccctggccgg ggccctgttc ctcaggagta agaggagcag gctcctgcac      660

agtgactaca tgaacatgac tccccgccgc cccgggccca cccgcaagca ttaccagccc      720

tatgccccac cacgcgactt cgcagcctat cgctcccgtt tctctgttgt taaacggggc      780

agaaagaagc tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa      840

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga      900

gtgaagttca gcaggagcgc agacgccccc gcgtaccagc agggccagaa ccagctctat      960

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     1020

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gtacaatgaa     1080

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     1140

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     1200

gacgcccttc acatgcaggc cctgccccct cgctaa                               1236


<210>  18
<211>  1242
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
atggcacggc cacatccctg gtggctgtgc gttctgggga ccctggtggg gctctcagct       60

actccagccc ccaagagctg cccagagagg cactactggg ctcagggaaa gctgtgctgc      120

cagatgtgtg agccaggaac attcctcgtg aaggactgtg accagcatag aaaggctgct      180

cagtgtgatc cttgcatacc gggggtctcc ttctctcctg accaccacac ccggccccac      240

tgtgagagct gtcggcactg taactctggt cttctcgttc gcaactgcac catcactgcc      300

aatgctgagt gtgcctgtcg caatggctgg cagtgcaggg acaaggagtg caccgagtgt      360

gatcctcttc caaacccttc gctgaccgct cggtcgtctc aggccctgag cccacaccct      420

cagcccaccc acttacctta tgtcagtgag atgctggagg ccaggacagc tgggcacatg      480

cagactctgg ctgacttcag gcagctgcct gcccggactc tctctaccca ctggccaccc      540

caaagatccc tgtgcagctc cgattttatt cgcatccttg tgatcttctc tggaatgttc      600

cttgttttca ccctggccgg ggccctgttc ctccatcaac gaaggaaata tagatcaaac      660

aaaggagaaa gtcctgtgga gcctgcagag ccttgtcgtt acagctgccc cagggaggag      720

gagggcagca ccatccccat ccaggaggat taccgaaaac cggagcctgc ctgctccccc      780

aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc      840

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      900

tccagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag      960

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt     1020

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac     1080

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     1140

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     1200

acctacgacg cccttcacat gcaggccctg ccccctcgct aa                        1242


<210>  19
<211>  1260
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
atggcacggc cacatccctg gtggctgtgc gttctgggga ccctggtggg gctctcagct       60

actccagccc ccaagagctg cccagagagg cactactggg ctcagggaaa gctgtgctgc      120

cagatgtgtg agccaggaac attcctcgtg aaggactgtg accagcatag aaaggctgct      180

cagtgtgatc cttgcatacc gggggtctcc ttctctcctg accaccacac ccggccccac      240

tgtgagagct gtcggcactg taactctggt cttctcgttc gcaactgcac catcactgcc      300

aatgctgagt gtgcctgtcg caatggctgg cagtgcaggg acaaggagtg caccgagtgt      360

gatcctcttc caaacccttc gctgaccgct cggtcgtctc aggccctgag cccacaccct      420

cagcccaccc acttacctta tgtcagtgag atgctggagg ccaggacagc tgggcacatg      480

cagactctgg ctgacttcag gcagctgcct gcccggactc tctctaccca ctggccaccc      540

caaagatccc tgtgcagctc cgattttatt cgcatccttg tgatcttctc tggaatgttc      600

cttgttttca ccctggccgg ggccctgttc ctccatcaac gaaggaaata tagatcaaac      660

aaaggagaaa gtcctgtgga gcctgcagag ccttgtcgtt acagctgccc cagggaggag      720

gagggcagca ccatccccat ccaggaggat taccgaaaac cggagcctgc ctgctccccc      780

cgtttctctg ttgttaaacg gggcagaaag aagctcctgt atatattcaa acaaccattt      840

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa      900

gaagaaggag gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac      960

cagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1020

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1080

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1140

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1200

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgctaa     1260


<210>  20
<211>  1383
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
atggcacggc cacatccctg gtggctgtgc gttctgggga ccctggtggg gctctcagct       60

actccagccc ccaagagctg cccagagagg cactactggg ctcagggaaa gctgtgctgc      120

cagatgtgtg agccaggaac attcctcgtg aaggactgtg accagcatag aaaggctgct      180

cagtgtgatc cttgcatacc gggggtctcc ttctctcctg accaccacac ccggccccac      240

tgtgagagct gtcggcactg taactctggt cttctcgttc gcaactgcac catcactgcc      300

aatgctgagt gtgcctgtcg caatggctgg cagtgcaggg acaaggagtg caccgagtgt      360

gatcctcttc caaacccttc gctgaccgct cggtcgtctc aggccctgag cccacaccct      420

cagcccaccc acttacctta tgtcagtgag atgctggagg ccaggacagc tgggcacatg      480

cagactctgg ctgacttcag gcagctgcct gcccggactc tctctaccca ctggccaccc      540

caaagatccc tgtgcagctc cgattttatt cgcatccttg tgatcttctc tggaatgttc      600

cttgttttca ccctggccgg ggccctgttc ctccatcaac gaaggaaata tagatcaaac      660

aaaggagaaa gtcctgtgga gcctgcagag ccttgtcgtt acagctgccc cagggaggag      720

gagggcagca ccatccccat ccaggaggat taccgaaaac cggagcctgc ctgctccccc      780

aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc      840

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      900

tcccgtttct ctgttgttaa acggggcaga aagaagctcc tgtatatatt caaacaacca      960

tttatgagac cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa     1020

gaagaagaag gaggatgtga actgagagtg aagttcagca ggagcgcaga cgcccccgcg     1080

taccagcagg gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac     1140

gatgttttgg acaagagacg tggccgggac cctgagatgg ggggaaagcc gagaaggaag     1200

aaccctcagg aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt     1260

gagattggga tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt     1320

ctcagtacag ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc     1380

taa                                                                   1383


<210>  21
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp 
            180                 185             


<210>  22
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  22

Phe Ile Arg Ile Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr 
1               5                   10                  15      


Leu Ala Gly Ala Leu Phe Leu 
            20              


<210>  23
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  23

His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu 
1               5                   10                  15      


Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser 
            20                  25                  30          


Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser 
        35                  40                  45              


Pro 
    


<210>  24
<211>  1092
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
atggcatggc cacctcccta ctggctctgc atgctgggga ccttggtagg actctcagct       60

accctagccc caaacagctg tccagacaaa cactactgga ctgggggagg actctgctgc      120

cggatgtgtg agccaggtac attctttgtg aaggactgtg aacaagacag aacagctgct      180

cagtgtgatc cctgtatacc aggcacctcc ttctctccag actaccacac ccggccccac      240

tgcgagagct gcaggcattg taactctggt tttcttatcc gcaactgcac agtcactgcc      300

aatgctgagt gcagctgttc caagaactgg cagtgcaggg accaggaatg tacagagtgt      360

gaccctcctc taaaccctgc actgaccaga cagccatctg agaccccgag cccacagcca      420

ccacccaccc acttacctca tggcacagag aagccatcct ggcccctaca caggcagctt      480

cccaactcga ctgtctatag ccagcggtca tcccatagac ccctgtgcag ctcggactgc      540

atccggatct ttgtgacctt ctccagcatg tttcttatct tcgtcctggg tgcaatcttg      600

ttcttccatc aaagaagaaa ccacgggcca aatgaagacc ggcaggcagt gcctgaagag      660

ccttgtcctt acagctgccc cagggaagag gagggcagtg ctatccctat ccaggaggac      720

taccggaaac ccgagcctgc tttctaccct agagcaaaat tcagcaggag tgcagagact      780

gctgccaacc tgcaggaccc caaccagctc tacaatgagc tcaatctagg gcgaagagag      840

gaatatgacg tcttggagaa gaagcgggct cgcgatccag agatgggagg caaacagcag      900

aggaggagga acccccagga aggcgtatac aatgcactgc agaaagacaa gatggcagaa      960

gcctacagtg agatcggcac aaaaggcgag aggcggagag gcaaggggca cgatggcctt     1020

taccagggtc tcagcactgc caccaaggac acctatgatg ccctgcatat gcagaccctg     1080

gcccctcgct aa                                                         1092


<210>  25
<211>  363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Met Ala Trp Pro Pro Pro Tyr Trp Leu Cys Met Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Leu Ala Pro Asn Ser Cys Pro Asp Lys His Tyr 
            20                  25                  30          


Trp Thr Gly Gly Gly Leu Cys Cys Arg Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Phe Val Lys Asp Cys Glu Gln Asp Arg Thr Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Thr Ser Phe Ser Pro Asp Tyr His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Phe Leu Ile Arg Asn Cys 
                85                  90                  95      


Thr Val Thr Ala Asn Ala Glu Cys Ser Cys Ser Lys Asn Trp Gln Cys 
            100                 105                 110         


Arg Asp Gln Glu Cys Thr Glu Cys Asp Pro Pro Leu Asn Pro Ala Leu 
        115                 120                 125             


Thr Arg Gln Pro Ser Glu Thr Pro Ser Pro Gln Pro Pro Pro Thr His 
    130                 135                 140                 


Leu Pro His Gly Thr Glu Lys Pro Ser Trp Pro Leu His Arg Gln Leu 
145                 150                 155                 160 


Pro Asn Ser Thr Val Tyr Ser Gln Arg Ser Ser His Arg Pro Leu Cys 
                165                 170                 175     


Ser Ser Asp Cys Ile Arg Ile Phe Val Thr Phe Ser Ser Met Phe Leu 
            180                 185                 190         


Ile Phe Val Leu Gly Ala Ile Leu Phe Phe His Gln Arg Arg Asn His 
        195                 200                 205             


Gly Pro Asn Glu Asp Arg Gln Ala Val Pro Glu Glu Pro Cys Pro Tyr 
    210                 215                 220                 


Ser Cys Pro Arg Glu Glu Glu Gly Ser Ala Ile Pro Ile Gln Glu Asp 
225                 230                 235                 240 


Tyr Arg Lys Pro Glu Pro Ala Phe Tyr Pro Arg Ala Lys Phe Ser Arg 
                245                 250                 255     


Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu Tyr Asn 
            260                 265                 270         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Glu Lys Lys 
        275                 280                 285             


Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln Gln Arg Arg Arg Asn 
    290                 295                 300                 


Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys Met Ala Glu 
305                 310                 315                 320 


Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly 
                325                 330                 335     


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
            340                 345                 350         


Asp Ala Leu His Met Gln Thr Leu Ala Pro Arg 
        355                 360             


<210>  26
<211>  250
<212>  PRT
<213>  Mus musculus

<400>  26

Met Ala Trp Pro Pro Pro Tyr Trp Leu Cys Met Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Leu Ala Pro Asn Ser Cys Pro Asp Lys His Tyr 
            20                  25                  30          


Trp Thr Gly Gly Gly Leu Cys Cys Arg Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Phe Val Lys Asp Cys Glu Gln Asp Arg Thr Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Thr Ser Phe Ser Pro Asp Tyr His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Phe Leu Ile Arg Asn Cys 
                85                  90                  95      


Thr Val Thr Ala Asn Ala Glu Cys Ser Cys Ser Lys Asn Trp Gln Cys 
            100                 105                 110         


Arg Asp Gln Glu Cys Thr Glu Cys Asp Pro Pro Leu Asn Pro Ala Leu 
        115                 120                 125             


Thr Arg Gln Pro Ser Glu Thr Pro Ser Pro Gln Pro Pro Pro Thr His 
    130                 135                 140                 


Leu Pro His Gly Thr Glu Lys Pro Ser Trp Pro Leu His Arg Gln Leu 
145                 150                 155                 160 


Pro Asn Ser Thr Val Tyr Ser Gln Arg Ser Ser His Arg Pro Leu Cys 
                165                 170                 175     


Ser Ser Asp Cys Ile Arg Ile Phe Val Thr Phe Ser Ser Met Phe Leu 
            180                 185                 190         


Ile Phe Val Leu Gly Ala Ile Leu Phe Phe His Gln Arg Arg Asn His 
        195                 200                 205             


Gly Pro Asn Glu Asp Arg Gln Ala Val Pro Glu Glu Pro Cys Pro Tyr 
    210                 215                 220                 


Ser Cys Pro Arg Glu Glu Glu Gly Ser Ala Ile Pro Ile Gln Glu Asp 
225                 230                 235                 240 


Tyr Arg Lys Pro Glu Pro Ala Phe Tyr Pro 
                245                 250 


<210>  27
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  27

Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp 
1               5                   10                  15      


Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro 
            100                 105                 110         


Arg 
    


