                         SEQUENCE LISTING

<110>  Yeda Research and Development Co. Ltd.
       University of Washington
       TAWFIK, Dan S.
       LEADER, Haim
       ASHANI, Yaacov
       CHERNY, Izhack
       GOLDSMITH, Moshe
       GREISEN, Per Jr.
       KHARE, Sagar D.
       OBERDORFER, Gustav
       BAKER, David
       FLEISHMAN, Sarel
       GOLDENZWEIG, Adi
       AGGARWAL, Nidhi
 
<120>  ISOLATED PHOSPHOTRIESTERASE POLYPEPTIDES, POLYNUCLEOTIDES 
       ENCODING SAME AND USES THEREOF IN TREATING OR PREVENTING 
       ORGANOPHOSPHATE EXPOSURE ASSOCIATED DAMAGE

<130>  64613

<150>  US 62/090,411
<151>  2014-12-11

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  727
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of C23 with MBP binding protein and signal 
       sequence -  no mutations

<400>  1

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn 
        355                 360                 365             


Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Leu Gly Ile 
    370                 375                 380                 


Glu Gly Arg Ile Ser Glu Phe Ile Thr Asn Ser Gly Asp Arg Ile Asn 
385                 390                 395                 400 


Thr Val Arg Gly Pro Ile Thr Ile Ser Glu Ala Gly Phe Thr Leu Thr 
                405                 410                 415     


His Glu His Ile Cys Gly Ser Ser Ala Gly Phe Leu Arg Ala Trp Pro 
            420                 425                 430         


Glu Phe Phe Gly Ser Arg Ala Ala Leu Val Glu Lys Ala Val Arg Gly 
        435                 440                 445             


Leu Arg Arg Ala Arg Ala Ala Gly Val Arg Thr Ile Val Asp Val Ser 
    450                 455                 460                 


Thr Phe Asp Ile Gly Arg Asp Val Ser Leu Leu Ala Glu Val Ser Arg 
465                 470                 475                 480 


Ala Ala Asp Val His Ile Val Ala Ala Thr Gly Leu Trp Glu Asp Pro 
                485                 490                 495     


Pro Leu Ser Met Arg Leu Arg Ser Val Glu Glu Leu Thr Gln Phe Phe 
            500                 505                 510         


Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp Thr Gly Ile Arg Ala Gly 
        515                 520                 525             


Ile Ile Lys Val Ala Thr Asn Gly Lys Ala Thr Pro Phe Gln Glu Leu 
    530                 535                 540                 


Val Leu Arg Ala Ala Ala Arg Ala Ser Leu Ala Thr Gly Val Pro Val 
545                 550                 555                 560 


Thr Thr His Thr Ala Ala Ser Gln Arg Asp Gly Glu Gln Gln Ala Ala 
                565                 570                 575     


Ile Phe Glu Ser Glu Gly Leu Ser Pro Ser Arg Val Cys Ile Gly His 
            580                 585                 590         


Ser Asp Asp Thr Asp Asp Leu Ser Tyr Leu Thr Ala Leu Ala Ala Arg 
        595                 600                 605             


Gly Tyr Leu Ile Gly Leu Asp Gly Ile Pro His Ser Ala Ile Gly Leu 
    610                 615                 620                 


Glu Asp Asn Ala Ser Ala Ser Ala Leu Leu Gly Asn Arg Ser Trp Gln 
625                 630                 635                 640 


Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp Gln Gly Tyr Met Lys 
                645                 650                 655     


Gln Ile Leu Val Ser Asn Asp Trp Leu Phe Gly Phe Ser Ser Tyr Val 
            660                 665                 670         


Thr Asn Ile Met Asp Val Met Asp Ser Val Asn Pro Asp Gly Met Ala 
        675                 680                 685             


Phe Ile Pro Leu Arg Val Ile Pro Phe Leu Arg Glu Lys Gly Val Ser 
    690                 695                 700                 


Gln Glu Thr Leu Ala Gly Ile Thr Val Thr Asn Pro Ala Arg Phe Leu 
705                 710                 715                 720 


Ser Pro Thr Leu Arg Ala Ser 
                725         


<210>  2
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of C23A203L for bacterial expression

<400>  2

Ile Thr Asn Ser Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr 
1               5                   10                  15      


Ile Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser 
            20                  25                  30          


Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala 
        35                  40                  45              


Ala Leu Val Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala 
    50                  55                  60                  


Gly Val Arg Thr Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp 
65                  70                  75                  80  


Val Ser Leu Leu Ala Glu Val Ser Arg Ala Ala Asp Val His Ile Val 
                85                  90                  95      


Ala Ala Thr Gly Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg 
            100                 105                 110         


Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly 
        115                 120                 125             


Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn 
    130                 135                 140                 


Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg 
145                 150                 155                 160 


Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Leu Ala Ser 
                165                 170                 175     


Gln Arg Asp Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         


Ser Pro Ser Arg Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu 
        195                 200                 205             


Ser Tyr Leu Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp 
    210                 215                 220                 


Gly Ile Pro His Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser 
225                 230                 235                 240 


Ala Leu Leu Gly Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys 
                245                 250                 255     


Ala Leu Ile Asp Gln Gly Tyr Met Lys Gln Ile Leu Val Ser Asn Asp 
            260                 265                 270         


Trp Leu Phe Gly Phe Ser Ser Tyr Val Thr Asn Ile Met Asp Val Met 
        275                 280                 285             


Asp Ser Val Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile 
    290                 295                 300                 


Pro Phe Leu Arg Glu Lys Gly Val Ser Gln Glu Thr Leu Ala Gly Ile 
305                 310                 315                 320 


Thr Val Thr Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330                 335     


<210>  3
<211>  727
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of C23A203L for bacterial expression with MBP
       and signal sequence

<400>  3

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn 
        355                 360                 365             


Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Leu Gly Ile 
    370                 375                 380                 


Glu Gly Arg Ile Ser Glu Phe Ile Thr Asn Ser Gly Asp Arg Ile Asn 
385                 390                 395                 400 


Thr Val Arg Gly Pro Ile Thr Ile Ser Glu Ala Gly Phe Thr Leu Thr 
                405                 410                 415     


His Glu His Ile Cys Gly Ser Ser Ala Gly Phe Leu Arg Ala Trp Pro 
            420                 425                 430         


Glu Phe Phe Gly Ser Arg Ala Ala Leu Val Glu Lys Ala Val Arg Gly 
        435                 440                 445             


Leu Arg Arg Ala Arg Ala Ala Gly Val Arg Thr Ile Val Asp Val Ser 
    450                 455                 460                 


Thr Phe Asp Ile Gly Arg Asp Val Ser Leu Leu Ala Glu Val Ser Arg 
465                 470                 475                 480 


Ala Ala Asp Val His Ile Val Ala Ala Thr Gly Leu Trp Glu Asp Pro 
                485                 490                 495     


Pro Leu Ser Met Arg Leu Arg Ser Val Glu Glu Leu Thr Gln Phe Phe 
            500                 505                 510         


Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp Thr Gly Ile Arg Ala Gly 
        515                 520                 525             


Ile Ile Lys Val Ala Thr Asn Gly Lys Ala Thr Pro Phe Gln Glu Leu 
    530                 535                 540                 


Val Leu Arg Ala Ala Ala Arg Ala Ser Leu Ala Thr Gly Val Pro Val 
545                 550                 555                 560 


Thr Thr His Thr Leu Ala Ser Gln Arg Asp Gly Glu Gln Gln Ala Ala 
                565                 570                 575     


Ile Phe Glu Ser Glu Gly Leu Ser Pro Ser Arg Val Cys Ile Gly His 
            580                 585                 590         


Ser Asp Asp Thr Asp Asp Leu Ser Tyr Leu Thr Ala Leu Ala Ala Arg 
        595                 600                 605             


Gly Tyr Leu Ile Gly Leu Asp Gly Ile Pro His Ser Ala Ile Gly Leu 
    610                 615                 620                 


Glu Asp Asn Ala Ser Ala Ser Ala Leu Leu Gly Asn Arg Ser Trp Gln 
625                 630                 635                 640 


Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp Gln Gly Tyr Met Lys 
                645                 650                 655     


Gln Ile Leu Val Ser Asn Asp Trp Leu Phe Gly Phe Ser Ser Tyr Val 
            660                 665                 670         


Thr Asn Ile Met Asp Val Met Asp Ser Val Asn Pro Asp Gly Met Ala 
        675                 680                 685             


Phe Ile Pro Leu Arg Val Ile Pro Phe Leu Arg Glu Lys Gly Val Ser 
    690                 695                 700                 


Gln Glu Thr Leu Ala Gly Ile Thr Val Thr Asn Pro Ala Arg Phe Leu 
705                 710                 715                 720 


Ser Pro Thr Leu Arg Ala Ser 
                725         


<210>  4
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of A 53 Q173N

<400>  4

Ile Thr Asn Ser Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr 
1               5                   10                  15      


Ile Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser 
            20                  25                  30          


Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala 
        35                  40                  45              


Ala Leu Val Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala 
    50                  55                  60                  


Gly Val Arg Thr Ile Val Asp Val Ser Thr Phe Asp Ala Gly Arg Asp 
65                  70                  75                  80  


Val Ser Leu Leu Ala Glu Val Ser Arg Ala Ala Asp Val His Ile Val 
                85                  90                  95      


Ala Ala Thr Gly Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg 
            100                 105                 110         


Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly 
        115                 120                 125             


Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn 
    130                 135                 140                 


Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg 
145                 150                 155                 160 


Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Phe Ala Ser 
                165                 170                 175     


Gln Arg Asp Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         


Ser Pro Ser Arg Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu 
        195                 200                 205             


Ser Tyr Leu Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp 
    210                 215                 220                 


Gly Ile Pro His Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser 
225                 230                 235                 240 


Ala Leu Leu Gly Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys 
                245                 250                 255     


Ala Leu Ile Asp Gln Gly Tyr Met Lys Gln Ile Leu Val Ser Asn Asp 
            260                 265                 270         


Trp Leu Phe Gly Phe Ser Ser Tyr Val Thr Asn Ile Met Asp Val Met 
        275                 280                 285             


Asp Ser Val Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile 
    290                 295                 300                 


Pro Phe Leu Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Gly Ile 
305                 310                 315                 320 


Thr Val Thr Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330                 335     


<210>  5
<211>  365
<212>  PRT
<213>  Brevundimonas diminuta

<400>  5

Met Gln Thr Arg Arg Val Val Leu Lys Ser Ala Ala Ala Ala Gly Thr 
1               5                   10                  15      


Leu Leu Gly Gly Leu Ala Gly Cys Ala Ser Val Ala Gly Ser Ile Gly 
            20                  25                  30          


Thr Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr Ile Ser Glu 
        35                  40                  45              


Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser Ser Ala Gly 
    50                  55                  60                  


Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Lys Ala Leu Ala 
65                  70                  75                  80  


Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala Gly Val Arg 
                85                  90                  95      


Thr Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp Val Ser Leu 
            100                 105                 110         


Leu Ala Glu Val Ser Arg Ala Ala Asp Val His Ile Val Ala Ala Thr 
        115                 120                 125             


Gly Leu Trp Phe Asp Pro Pro Leu Ser Met Arg Leu Arg Ser Val Glu 
    130                 135                 140                 


Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp 
145                 150                 155                 160 


Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Thr Gly Lys Ala 
                165                 170                 175     


Thr Pro Phe Gln Glu Leu Val Leu Lys Ala Ala Ala Arg Ala Ser Leu 
            180                 185                 190         


Ala Thr Gly Val Pro Val Thr Thr His Thr Ala Ala Ser Gln Arg Asp 
        195                 200                 205             


Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu Ser Pro Ser 
    210                 215                 220                 


Arg Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu Ser Tyr Leu 
225                 230                 235                 240 


Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp His Ile Pro 
                245                 250                 255     


His Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser Ala Leu Leu 
            260                 265                 270         


Gly Ile Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile 
        275                 280                 285             


Asp Gln Gly Tyr Met Lys Gln Ile Leu Val Ser Asn Asp Trp Leu Phe 
    290                 295                 300                 


Gly Phe Ser Ser Tyr Val Thr Asn Ile Met Asp Val Met Asp Arg Val 
305                 310                 315                 320 


Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile Pro Phe Leu 
                325                 330                 335     


Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Gly Ile Thr Val Thr 
            340                 345                 350         


Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
        355                 360                 365 


<210>  6
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of PTE expressed in E.Coli without the MBP 
       binding protein

<400>  6

Ile Thr Asn Ser Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr 
1               5                   10                  15      


Ile Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser 
            20                  25                  30          


Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Lys 
        35                  40                  45              


Ala Leu Ala Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala 
    50                  55                  60                  


Gly Val Arg Thr Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp 
65                  70                  75                  80  


Val Ser Leu Leu Ala Glu Val Ser Arg Ala Ala Asp Val His Ile Val 
                85                  90                  95      


Ala Ala Thr Gly Leu Trp Phe Asp Pro Pro Leu Ser Met Arg Leu Arg 
            100                 105                 110         


Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly 
        115                 120                 125             


Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Thr 
    130                 135                 140                 


Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg 
145                 150                 155                 160 


Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Ala Ala Ser 
                165                 170                 175     


Gln Arg Gly Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         


Ser Pro Ser Arg Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu 
        195                 200                 205             


Ser Tyr Leu Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp 
    210                 215                 220                 


His Ile Pro His Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser 
225                 230                 235                 240 


Ala Leu Leu Gly Ile Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys 
                245                 250                 255     


Ala Leu Ile Asp Gln Gly Tyr Met Lys Gln Ile Leu Val Ser Asn Asp 
            260                 265                 270         


Trp Leu Phe Gly Phe Ser Ser Tyr Val Thr Asn Ile Met Asp Val Met 
        275                 280                 285             


Asp Ser Val Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile 
    290                 295                 300                 


Pro Phe Leu Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Gly Ile 
305                 310                 315                 320 


Thr Val Thr Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330                 335     


<210>  7
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of PTE expressed in E.Coli with the MBP 
       binding protein (no additional mutations)

<400>  7

His Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp 
1               5                   10                  15      


Lys Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp 
            20                  25                  30          


Thr Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys 
        35                  40                  45              


Phe Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp 
    50                  55                  60                  


Ala His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu 
65                  70                  75                  80  


Ile Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp 
                85                  90                  95      


Asp Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val 
            100                 105                 110         


Glu Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro 
        115                 120                 125             


Lys Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys 
    130                 135                 140                 


Gly Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp 
145                 150                 155                 160 


Pro Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly 
                165                 170                 175     


Lys Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala 
            180                 185                 190         


Gly Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala 
        195                 200                 205             


Asp Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr 
    210                 215                 220                 


Ala Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser 
225                 230                 235                 240 


Lys Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro 
                245                 250                 255     


Ser Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser 
            260                 265                 270         


Pro Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr 
        275                 280                 285             


Asp Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val 
    290                 295                 300                 


Ala Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala 
305                 310                 315                 320 


Ala Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro 
                325                 330                 335     


Gln Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala 
            340                 345                 350         


Ala Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr 
        355                 360                 365             


Asn Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Leu Gly 
    370                 375                 380                 


Ile Glu Gly Arg Ile Ser Glu Phe Ile Thr Asn Ser Gly Asp Arg Ile 
385                 390                 395                 400 


Asn Thr Val Arg Gly Pro Ile Thr Ile Ser Glu Ala Gly Phe Thr Leu 
                405                 410                 415     


Thr His Glu His Ile Cys Gly Ser Ser Ala Gly Phe Leu Arg Ala Trp 
            420                 425                 430         


Pro Glu Phe Phe Gly Ser Arg Lys Ala Leu Ala Glu Lys Ala Val Arg 
        435                 440                 445             


Gly Leu Arg Arg Ala Arg Ala Ala Gly Val Arg Thr Ile Val Asp Val 
    450                 455                 460                 


Ser Thr Phe Asp Ile Gly Arg Asp Val Ser Leu Leu Ala Glu Val Ser 
465                 470                 475                 480 


Arg Ala Ala Asp Val His Ile Val Ala Ala Thr Gly Leu Trp Phe Asp 
                485                 490                 495     


Pro Pro Leu Ser Met Arg Leu Arg Ser Val Glu Glu Leu Thr Gln Phe 
            500                 505                 510         


Phe Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp Thr Gly Ile Arg Ala 
        515                 520                 525             


Gly Ile Ile Lys Val Ala Thr Thr Gly Lys Ala Thr Pro Phe Gln Glu 
    530                 535                 540                 


Leu Val Leu Arg Ala Ala Ala Arg Ala Ser Leu Ala Thr Gly Val Pro 
545                 550                 555                 560 


Val Thr Thr His Thr Ala Ala Ser Gln Arg Gly Gly Glu Gln Gln Ala 
                565                 570                 575     


Ala Ile Phe Glu Ser Glu Gly Leu Ser Pro Ser Arg Val Cys Ile Gly 
            580                 585                 590         


His Ser Asp Asp Thr Asp Asp Leu Ser Tyr Leu Thr Ala Leu Ala Ala 
        595                 600                 605             


Arg Gly Tyr Leu Ile Gly Leu Asp His Ile Pro His Ser Ala Ile Gly 
    610                 615                 620                 


Leu Glu Asp Asn Ala Ser Ala Ser Ala Leu Leu Gly Ile Arg Ser Trp 
625                 630                 635                 640 


Gln Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp Gln Gly Tyr Met 
                645                 650                 655     


Lys Gln Ile Leu Val Ser Asn Asp Trp Leu Phe Gly Phe Ser Ser Tyr 
            660                 665                 670         


Val Thr Asn Ile Met Asp Val Met Asp Ser Val Asn Pro Asp Gly Met 
        675                 680                 685             


Ala Phe Ile Pro Leu Arg Val Ile Pro Phe Leu Arg Glu Lys Gly Val 
    690                 695                 700                 


Pro Gln Glu Thr Leu Ala Gly Ile Thr Val Thr Asn Pro Ala Arg Phe 
705                 710                 715                 720 


Leu Ser Pro Thr Leu Arg Ala Ser 
                725             


<210>  8
<211>  727
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of  A53 Q173N for bacterial expression +MBP

<400>  8

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn 
        355                 360                 365             


Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Leu Gly Ile 
    370                 375                 380                 


Glu Gly Arg Ile Ser Glu Phe Ile Thr Asn Ser Gly Asp Arg Ile Asn 
385                 390                 395                 400 


Thr Val Arg Gly Pro Ile Thr Ile Ser Glu Ala Gly Phe Thr Leu Thr 
                405                 410                 415     


His Glu His Ile Cys Gly Ser Ser Ala Gly Phe Leu Arg Ala Trp Pro 
            420                 425                 430         


Glu Phe Phe Gly Ser Arg Ala Ala Leu Val Glu Lys Ala Val Arg Gly 
        435                 440                 445             


Leu Arg Arg Ala Arg Ala Ala Gly Val Arg Thr Ile Val Asp Val Ser 
    450                 455                 460                 


Thr Phe Asp Ala Gly Arg Asp Val Ser Leu Leu Ala Glu Val Ser Arg 
465                 470                 475                 480 


Ala Ala Asp Val His Ile Val Ala Ala Thr Gly Leu Trp Glu Asp Pro 
                485                 490                 495     


Pro Leu Ser Met Arg Leu Arg Ser Val Glu Glu Leu Thr Gln Phe Phe 
            500                 505                 510         


Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp Thr Gly Ile Arg Ala Gly 
        515                 520                 525             


Ile Ile Lys Val Ala Thr Asn Gly Lys Ala Thr Pro Phe Gln Glu Leu 
    530                 535                 540                 


Val Leu Arg Ala Ala Ala Arg Ala Ser Leu Ala Thr Gly Val Pro Val 
545                 550                 555                 560 


Thr Thr His Thr Phe Ala Ser Gln Arg Asp Gly Glu Gln Gln Ala Ala 
                565                 570                 575     


Ile Phe Glu Ser Glu Gly Leu Ser Pro Ser Arg Val Cys Ile Gly His 
            580                 585                 590         


Ser Asp Asp Thr Asp Asp Leu Ser Tyr Leu Thr Ala Leu Ala Ala Arg 
        595                 600                 605             


Gly Tyr Leu Ile Gly Leu Asp Gly Ile Pro His Ser Ala Ile Gly Leu 
    610                 615                 620                 


Glu Asp Asn Ala Ser Ala Ser Ala Leu Leu Gly Asn Arg Ser Trp Gln 
625                 630                 635                 640 


Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp Gln Gly Tyr Met Lys 
                645                 650                 655     


Gln Ile Leu Val Ser Asn Asp Trp Leu Phe Gly Phe Ser Ser Tyr Val 
            660                 665                 670         


Thr Asn Ile Met Asp Val Met Asp Ser Val Asn Pro Asp Gly Met Ala 
        675                 680                 685             


Phe Ile Pro Leu Arg Val Ile Pro Phe Leu Arg Glu Lys Gly Val Pro 
    690                 695                 700                 


Gln Glu Thr Leu Ala Gly Ile Thr Val Thr Asn Pro Ala Arg Phe Leu 
705                 710                 715                 720 


Ser Pro Thr Leu Arg Ala Ser 
                725         


<210>  9
<211>  2184
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MBP-C23-A203L DNA coding sequence

<400>  9
atgaaaatcg aagaaggtaa actggtaatc tggattaacg gcgataaagg ctataacggt       60

ctcgctgaag tcggtaagaa attcgagaaa gataccggaa ttaaagtcac cgttgagcat      120

ccggataaac tggaagagaa attcccacag gttgcggcaa ctggcgatgg ccctgacatt      180

atcttctggg cacacgaccg ctttggtggc tacgctcaat ctggcctgtt ggctgaaatc      240

accccggaca aagcgttcca ggacaagctg tatccgttta cctgggatgc cgtacgttac      300

aacggcaagc tgattgctta cccgatcgct gttgaagcgt tatcgctgat ttataacaaa      360

gatctgctgc cgaacccgcc aaaaacctgg gaagagatcc cggcgctgga taaagaactg      420

aaagcgaaag gtaagagcgc gctgatgttc aacctgcaag aaccgtactt cacctggccg      480

ctgattgctg ctgacggggg ttatgcgttc aagtatgaaa acggcaagta cgacattaaa      540

gacgtgggcg tggataacgc tggcgcgaaa gcgggtctga ccttcctggt tgacctgatt      600

aaaaacaaac acatgaatgc agacaccgat tactccatcg cagaagctgc ctttaataaa      660

ggcgaaacag cgatgaccat caacggcccg tgggcatggt ccaacatcga caccagcaaa      720

gtgaattatg gtgtaacggt actgccgacc ttcaagggtc aaccatccaa accgttcgtt      780

ggcgtgctga gcgcaggtat taacgccgcc agtccgaaca aagagctggc aaaagagttc      840

ctcgaaaact atctgctgac tgatgaaggt ctggaagcgg ttaataaaga caaaccgctg      900

ggtgccgtag cgctgaagtc ttacgaggaa gagttggcga aagatccacg tattgccgcc      960

actatggaaa acgcccagaa aggtgaaatc atgccgaaca tcccgcagat gtccgctttc     1020

tggtatgccg tgcgtactgc ggtgatcaac gccgccagcg gtcgtcagac tgtcgatgaa     1080

gccctgaaag acgcgcagac taattcgagc tcgaacaaca acaacaataa caataacaac     1140

aacctcggga tcgagggaag gatttcagaa ttcatcacca acagcggcga tcggatcaat     1200

accgtgcgcg gtcctatcac aatctctgaa gcgggtttca cactgactca cgagcacatc     1260

tgcggcagct cggcaggatt cttgcgtgct tggccggagt tcttcggtag ccgcgcagcc     1320

ctagtggaaa aggctgtgag aggattgcgc cgcgccagag cggctggcgt gcgaacgatt     1380

gtcgatgtgt cgactttcga tatcggtcgc gatgtcagtt tattggccga ggtttcgcgg     1440

gctgccgacg ttcatatcgt ggcggcgacc ggcttgtggg aggacccgcc actttcgatg     1500

cggttgagga gtgtagagga actcacacag ttcttcctgc gtgagattca atatggcatc     1560

gaagacaccg gaattagggc gggcattatc aaggtcgcga ccaatggcaa ggcgaccccc     1620

tttcaggagt tagtgttaag ggcggccgcc cgggccagct tggccaccgg tgttccggta     1680

accactcaca cgttggcaag tcagcgcgat ggtgagcagc aggccgccat ttttgagtcc     1740

gaaggcttga gcccctcacg agtttgtatt ggtcacagcg atgatactga cgatttgagc     1800

tatctcaccg ccctcgctgc gcgcggatac ctcatcggtc tagacggcat cccgcacagt     1860

gcgattggtc tagaagataa tgcgagtgca tcagccctcc tgggcaaccg ttcgtggcaa     1920

acacgggctc tcttgatcaa ggcgctcatc gaccaaggct acatgaaaca aatcctcgtt     1980

tcgaatgact ggctgttcgg gttttcgagc tatgtcacca acatcatgga cgtgatggat     2040

agcgtgaacc ccgacgggat ggccttcatt ccactgagag tgatcccatt cctacgagag     2100

aagggcgtct cacaggaaac gctggcaggc atcactgtga ccaacccggc gcggttcttg     2160

tcaccgacct tgcgggcgtc atga                                            2184


<210>  10
<211>  2184
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MBP-A53-Q173N DNA coding sequence

<400>  10
atgaaaatcg aagaaggtaa actggtaatc tggattaacg gcgataaagg ctataacggt       60

ctcgctgaag tcggtaagaa attcgagaaa gataccggaa ttaaagtcac cgttgagcat      120

ccggataaac tggaagagaa attcccacag gttgcggcaa ctggcgatgg ccctgacatt      180

atcttctggg cacacgaccg ctttggtggc tacgctcaat ctggcctgtt ggctgaaatc      240

accccggaca aagcgttcca ggacaagctg tatccgttta cctgggatgc cgtacgttac      300

aacggcaagc tgattgctta cccgatcgct gttgaagcgt tatcgctgat ttataacaaa      360

gatctgctgc cgaacccgcc aaaaacctgg gaagagatcc cggcgctgga taaagaactg      420

aaagcgaaag gtaagagcgc gctgatgttc aacctgcaag aaccgtactt cacctggccg      480

ctgattgctg ctgacggggg ttatgcgttc aagtatgaaa acggcaagta cgacattaaa      540

gacgtgggcg tggataacgc tggcgcgaaa gcgggtctga ccttcctggt tgacctgatt      600

aaaaacaaac acatgaatgc agacaccgat tactccatcg cagaagctgc ctttaataaa      660

ggcgaaacag cgatgaccat caacggcccg tgggcatggt ccaacatcga caccagcaaa      720

gtgaattatg gtgtaacggt actgccgacc ttcaagggtc aaccatccaa accgttcgtt      780

ggcgtgctga gcgcaggtat taacgccgcc agtccgaaca aagagctggc aaaagagttc      840

ctcgaaaact atctgctgac tgatgaaggt ctggaagcgg ttaataaaga caaaccgctg      900

ggtgccgtag cgctgaagtc ttacgaggaa gagttggcga aagatccacg tattgccgcc      960

actatggaaa acgcccagaa aggtgaaatc atgccgaaca tcccgcagat gtccgctttc     1020

tggtatgccg tgcgtactgc ggtgatcaac gccgccagcg gtcgtcagac tgtcgatgaa     1080

gccctgaaag acgcgcagac taattcgagc tcgaacaaca acaacaataa caataacaac     1140

aacctcggga tcgagggaag gatttcagaa ttcatcacca acagcggcga tcggatcaat     1200

accgtgcgcg gtcctatcac aatctctgaa gcgggtttca cactgactca cgagcacatc     1260

tgcggcagct cggcaggatt cttgcgtgct tggccggagt tcttcggtag ccgcgcagcc     1320

ctagtggaaa aggctgtgag aggattgcgc cgcgccagag cggctggcgt gcgaacgatt     1380

gtcgatgtgt cgactttcga tgccggtcgc gatgtcagtt tattggccga ggtttcgcgg     1440

gctgccgacg ttcatatcgt ggcggcgacc ggcttgtggg aggacccgcc actttcgatg     1500

cggttgagga gtgtagagga actcacacag ttcttcctgc gtgagattca atatggcatc     1560

gaagacaccg gaattagggc gggcattatc aaggtcgcga ccaatggcaa ggcgaccccc     1620

tttcaggagt tagtgttaag ggcggccgcc cgggccagct tggccaccgg tgttccggta     1680

accactcaca cgtttgcaag tcagcgcgat ggtgagcagc aggccgccat ttttgagtcc     1740

gaaggcttga gcccctcacg agtttgtatt ggtcacagcg atgatactga cgatttgagc     1800

tatctcaccg ccctcgctgc gcgcggatac ctcatcggtc tagacggcat cccgcacagt     1860

gcgattggtc tagaagataa tgcgagtgca tcagccctcc tgggcaaccg ttcgtggcaa     1920

acacgggctc tcttgatcaa ggcgctcatc gaccaaggct acatgaaaca aatcctcgtt     1980

tcgaatgact ggctgttcgg gttttcgagc tatgtcacca acatcatgga cgtgatggat     2040

agcgtgaacc ccgacgggat ggccttcatt ccactgagag tgatcccatt cctacgagag     2100

aagggcgtcc cacaggaaac gctggcaggc atcactgtga ccaacccggc gcggttcttg     2160

tcaccgacct tgcgggcgtc atga                                            2184


<210>  11
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  genetically modified polypeptide

<400>  11

Ile Thr Asn Ser Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr 
1               5                   10                  15      


Ile Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser 
            20                  25                  30          


Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala 
        35                  40                  45              


Ala Leu Val Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala 
    50                  55                  60                  


Gly Val Arg Thr Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp 
65                  70                  75                  80  


Val Ser Leu Leu Ala Glu Val Ser Arg Ala Ala Asp Val His Ile Val 
                85                  90                  95      


Ala Ala Thr Gly Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg 
            100                 105                 110         


Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly 
        115                 120                 125             


Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn 
    130                 135                 140                 


Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg 
145                 150                 155                 160 


Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Ala Ala Ser 
                165                 170                 175     


Gln Arg Asp Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         


Ser Pro Ser Arg Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu 
        195                 200                 205             


Ser Tyr Leu Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp 
    210                 215                 220                 


Gly Ile Pro His Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser 
225                 230                 235                 240 


Ala Leu Leu Gly Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys 
                245                 250                 255     


Ala Leu Ile Asp Gln Gly Tyr Met Lys Gln Ile Leu Val Ser Asn Asp 
            260                 265                 270         


Trp Leu Phe Gly Phe Ser Ser Trp Val Thr Asn Ile Met Asp Val Met 
        275                 280                 285             


Asp Ser Val Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile 
    290                 295                 300                 


Pro Phe Leu Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Gly Ile 
305                 310                 315                 320 


Thr Val Thr Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330                 335     


<210>  12
<211>  1011
<212>  DNA
<213>  Artificial sequence

<220>
<223>  polynucleotide sequence encoding seq ID 11

<400>  12
atcaccaaca gcggcgatcg gatcaatacc gtgcgcggtc ctatcacaat ctctgaagcg       60

ggtttcacac tgactcacga gcacatctgc ggcagctcgg caggattctt gcgtgcttgg      120

ccggagttct tcggtagccg cgcagcccta gtggaaaagg ctgtgagagg attgcgccgc      180

gccagagcgg ctggcgtgcg aacgattgtc gatgtgtcga ctttcgatat cggtcgcgat      240

gtcagtttat tggccgaggt ttcgcgggct gccgacgttc atatcgtggc ggcgaccggc      300

ttgtgggagg acccgccact ttcgatgcgg ttgaggagtg tagaggaact cacacagttc      360

ttcctgcgtg agattcaata tggcatcgaa gacaccggaa ttagggcggg cattatcaag      420

gtcgcgacca atggcaaggc gacccccttt caggagttag tgttaagggc ggccgcccgg      480

gccagcttgg ccaccggtgt tccggtaacc actcacacgg cagcaagtca gcgcgatggt      540

gagcagcagg ccgccatttt tgagtccgaa ggcttgagcc cctcacgagt ttgtattggt      600

cacagcgatg atactgacga tttgagctat ctcaccgccc tcgctgcgcg cggatacctc      660

atcggtctag acggcatccc gcacagtgcg attggtctag aagataatgc gagtgcatca      720

gccctcctgg gcaaccgttc gtggcaaaca cgggctctct tgatcaaggc gctcatcgac      780

caaggctaca tgaaacaaat cctcgtttcg aatgactggc tgttcgggtt ttcgagctgg      840

gtcaccaaca tcatggacgt gatggatagc gtgaaccccg acgggatggc cttcattcca      900

ctgagagtga tcccattcct acgagagaag ggcgtctcac aggaaacgct ggcaggcatc      960

actgtgacca acccggcgcg gttcttgtca ccgaccttgc gggcgtcatg a              1011


<210>  13
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  genetically modified polypeptide

<400>  13

Ile Thr Asn Ser Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr 
1               5                   10                  15      


Ile Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser 
            20                  25                  30          


Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala 
        35                  40                  45              


Ala Leu Val Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala 
    50                  55                  60                  


Gly Val Arg Thr Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp 
65                  70                  75                  80  


Val Ser Leu Leu Ala Glu Val Ser Arg Ala Ala Asp Val His Ile Val 
                85                  90                  95      


Ala Ala Thr Gly Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg 
            100                 105                 110         


Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly 
        115                 120                 125             


Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn 
    130                 135                 140                 


Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg 
145                 150                 155                 160 


Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Leu Ala Ser 
                165                 170                 175     


Gln Arg Asp Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         


Ser Pro Ser Arg Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu 
        195                 200                 205             


Ser Tyr Leu Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp 
    210                 215                 220                 


Gly Ile Pro His Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser 
225                 230                 235                 240 


Ala Gly Trp Gly Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys 
                245                 250                 255     


Ala Leu Ile Asp Gln Gly Tyr Met Lys Gln Ile Leu Val Ser Asn Asp 
            260                 265                 270         


Trp Leu Phe Gly Phe Ser Ser Tyr Val Thr Asn Ile Met Asp Val Met 
        275                 280                 285             


Asp Ser Val Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile 
    290                 295                 300                 


Pro Phe Leu Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Gly Ile 
305                 310                 315                 320 


Thr Val Thr Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330                 335     


<210>  14
<211>  1011
<212>  DNA
<213>  Artificial sequence

<220>
<223>  polynucleotide sequence encoding seq ID 13

<400>  14
atcaccaaca gcggcgatcg gatcaatacc gtgcgcggtc ctatcacaat ctctgaagcg       60

ggtttcacac tgactcacga gcacatctgc ggcagctcgg caggattctt gcgtgcttgg      120

ccggagttct tcggtagccg cgcagcccta gtggaaaagg ctgtgagagg attgcgccgc      180

gccagagcgg ctggcgtgcg aacgattgtc gatgtgtcga ctttcgatat cggtcgcgat      240

gtcagtttat tggccgaggt ttcgcgggct gccgacgttc atatcgtggc ggcgaccggc      300

ttgtgggagg acccgccact ttcgatgcgg ttgaggagtg tagaggaact cacacagttc      360

ttcctgcgtg agattcaata tggcatcgaa gacaccggaa ttagggcggg cattatcaag      420

gtcgcgacca atggcaaggc gacccccttt caggagttag tgttaagggc ggccgcccgg      480

gccagcttgg ccaccggtgt tccggtaacc actcacacgt tggcaagtca gcgcgatggt      540

gagcagcagg ccgccatttt tgagtccgaa ggcttgagcc cctcacgagt ttgtattggt      600

cacagcgatg atactgacga tttgagctat ctcaccgccc tcgctgcgcg cggatacctc      660

atcggtctag acggcatccc gcacagtgcg attggtctag aagataatgc gagtgcatca      720

gccggatggg gcaaccgttc gtggcaaaca cgggctctct tgatcaaggc gctcatcgac      780

caaggctaca tgaaacaaat cctcgtttcg aatgactggc tgttcgggtt ttcgagctat      840

gtcaccaaca tcatggacgt gatggatagc gtgaaccccg acgggatggc cttcattcca      900

ctgagagtga tcccattcct acgagagaag ggcgtctcac aggaaacgct ggcaggcatc      960

actgtgacca acccggcgcg gttcttgtca ccgaccttgc gggcgtcatg a              1011


<210>  15
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  genetically modified polypeptide

<400>  15

Ile Thr Asn Ser Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr 
1               5                   10                  15      


Ile Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser 
            20                  25                  30          


Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala 
        35                  40                  45              


Ala Leu Val Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala 
    50                  55                  60                  


Gly Val Arg Thr Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp 
65                  70                  75                  80  


Val Ser Leu Leu Ala Glu Val Ser Arg Ala Ala Asp Val His Ile Val 
                85                  90                  95      


Ala Ala Thr Gly Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg 
            100                 105                 110         


Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly 
        115                 120                 125             


Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn 
    130                 135                 140                 


Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg 
145                 150                 155                 160 


Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Leu Ala Ser 
                165                 170                 175     


Gln Arg Asp Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         


Ser Pro Ser Arg Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu 
        195                 200                 205             


Ser Tyr Leu Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp 
    210                 215                 220                 


Gly Ile Pro His Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser 
225                 230                 235                 240 


Ala Arg Leu Gly Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys 
                245                 250                 255     


Ala Leu Ile Asp Gln Gly Tyr Met Lys Gln Ile Leu Val Ser Asn Asp 
            260                 265                 270         


Trp Leu Phe Gly Phe Ser Ser Tyr Val Thr Asn Ile Met Asp Val Met 
        275                 280                 285             


Asp Ser Val Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile 
    290                 295                 300                 


Pro Phe Leu Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Gly Ile 
305                 310                 315                 320 


Thr Val Thr Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330                 335     


<210>  16
<211>  1011
<212>  DNA
<213>  Artificial sequence

<220>
<223>  polynucleotide sequence encoding seq ID 15

<400>  16
atcaccaaca gcggcgatcg gatcaatacc gtgcgcggtc ctatcacaat ctctgaagcg       60

ggtttcacac tgactcacga gcacatctgc ggcagctcgg caggattctt gcgtgcttgg      120

ccggagttct tcggtagccg cgcagcccta gtggaaaagg ctgtgagagg attgcgccgc      180

gccagagcgg ctggcgtgcg aacgattgtc gatgtgtcga ctttcgatat cggtcgcgat      240

gtcagtttat tggccgaggt ttcgcgggct gccgacgttc atatcgtggc ggcgaccggc      300

ttgtgggagg acccgccact ttcgatgcgg ttgaggagtg tagaggaact cacacagttc      360

ttcctgcgtg agattcaata tggcatcgaa gacaccggaa ttagggcggg cattatcaag      420

gtcgcgacca atggcaaggc gacccccttt caggagttag tgttaagggc ggccgcccgg      480

gccagcttgg ccaccggtgt tccggtaacc actcacacgt tggcaagtca gcgcgatggt      540

gagcagcagg ccgccatttt tgagtccgaa ggcttgagcc cctcacgagt ttgtattggt      600

cacagcgatg atactgacga tttgagctat ctcaccgccc tcgctgcgcg cggatacctc      660

atcggtctag acggcatccc gcacagtgcg attggtctag aagataatgc gagtgcatca      720

gccaggctgg gcaaccgttc gtggcaaaca cgggctctct tgatcaaggc gctcatcgac      780

caaggctaca tgaaacaaat cctcgtttcg aatgactggc tgttcgggtt ttcgagctat      840

gtcaccaaca tcatggacgt gatggatagc gtgaaccccg acgggatggc cttcattcca      900

ctgagagtga tcccattcct acgagagaag ggcgtctcac aggaaacgct ggcaggcatc      960

actgtgacca acccggcgcg gttcttgtca ccgaccttgc gggcgtcatg a              1011


<210>  17
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  genetically modified polypeptide

<400>  17

Ile Thr Asn Ser Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr 
1               5                   10                  15      


Ile Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser 
            20                  25                  30          


Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala 
        35                  40                  45              


Ala Leu Val Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala 
    50                  55                  60                  


Gly Val Arg Thr Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp 
65                  70                  75                  80  


Val Ser Leu Leu Ala Glu Val Ser Arg Ala Ala Asp Val His Ile Val 
                85                  90                  95      


Ala Ala Thr Gly Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg 
            100                 105                 110         


Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly 
        115                 120                 125             


Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn 
    130                 135                 140                 


Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg 
145                 150                 155                 160 


Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Ala Ala Ser 
                165                 170                 175     


Gln Arg Asp Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         


Ser Pro Ser Arg Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu 
        195                 200                 205             


Ser Tyr Leu Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp 
    210                 215                 220                 


Gly Ile Pro His Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser 
225                 230                 235                 240 


Glu Leu Leu Gly Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys 
                245                 250                 255     


Ala Leu Ile Asp Gln Gly Tyr Met Lys Gln Ile Leu Val Ser Asn Asp 
            260                 265                 270         


Trp Leu Phe Gly Phe Ser Ser Trp Val Thr Asn Ile Met Asp Val Met 
        275                 280                 285             


Asp Ser Val Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile 
    290                 295                 300                 


Pro Phe Leu Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Gly Ile 
305                 310                 315                 320 


Thr Val Thr Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330                 335     


<210>  18
<211>  1011
<212>  DNA
<213>  Artificial sequence

<220>
<223>  polynucleotide sequence encoding seq ID 17

<400>  18
atcaccaaca gcggcgatcg gatcaatacc gtgcgcggtc ctatcacaat ctctgaagcg       60

ggtttcacac tgactcacga gcacatctgc ggcagctcgg caggattctt gcgtgcttgg      120

ccggagttct tcggtagccg cgcagcccta gtggaaaagg ctgtgagagg attgcgccgc      180

gccagagcgg ctggcgtgcg aacgattgtc gatgtgtcga ctttcgatat cggtcgcgat      240

gtcagtttat tggccgaggt ttcgcgggct gccgacgttc atatcgtggc ggcgaccggc      300

ttgtgggagg acccgccact ttcgatgcgg ttgaggagtg tagaggaact cacacagttc      360

ttcctgcgtg agattcaata tggcatcgaa gacaccggaa ttagggcggg cattatcaag      420

gtcgcgacca atggcaaggc gacccccttt caggagttag tgttaagggc ggccgcccgg      480

gccagcttgg ccaccggtgt tccggtaacc actcacacgg cagcaagtca gcgcgatggt      540

gagcagcagg ccgccatttt tgagtccgaa ggcttgagcc cctcacgagt ttgtattggt      600

cacagcgatg atactgacga tttgagctat ctcaccgccc tcgctgcgcg cggatacctc      660

atcggtctag acggcatccc gcacagtgcg attggtctag aagataatgc gagtgcatca      720

gaactcctgg gcaaccgttc gtggcaaaca cgggctctct tgatcaaggc gctcatcgac      780

caaggctaca tgaaacaaat cctcgtttcg aatgactggc tgttcgggtt ttcgagctgg      840

gtcaccaaca tcatggacgt gatggatagc gtgaaccccg acgggatggc cttcattcca      900

ctgagagtga tcccattcct acgagagaag ggcgtctcac aggaaacgct ggcaggcatc      960

actgtgacca acccggcgcg gttcttgtca ccgaccttgc gggcgtcatg a              1011


<210>  19
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  genetically modified polypeptide

<400>  19

Ile Thr Asn Ser Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr 
1               5                   10                  15      


Ile Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser 
            20                  25                  30          


Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala 
        35                  40                  45              


Ala Leu Val Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala 
    50                  55                  60                  


Gly Val Arg Thr Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp 
65                  70                  75                  80  


Val Ser Leu Leu Ala Glu Val Ser Arg Ala Ala Asp Val His Ile Val 
                85                  90                  95      


Ala Ala Thr Gly Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg 
            100                 105                 110         


Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly 
        115                 120                 125             


Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn 
    130                 135                 140                 


Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg 
145                 150                 155                 160 


Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Leu Ala Ser 
                165                 170                 175     


Gln Arg Asp Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         


Ser Pro Ser Arg Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu 
        195                 200                 205             


Ser Tyr Leu Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp 
    210                 215                 220                 


Gly Ile Pro His Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser 
225                 230                 235                 240 


Ala Leu Leu Gly Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys 
                245                 250                 255     


Ala Leu Ile Asp Gln Gly Tyr Met Lys Gln Ile Leu Val Ser Asn Asp 
            260                 265                 270         


Trp Leu Phe Gly Phe Ser Ser Trp Val Thr Asn Ile Met Asp Val Met 
        275                 280                 285             


Asp Ser Val Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile 
    290                 295                 300                 


Pro Phe Leu Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Gly Ile 
305                 310                 315                 320 


Thr Val Thr Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330                 335     


<210>  20
<211>  1011
<212>  DNA
<213>  Artificial sequence

<220>
<223>  polynucleotide sequence encoding seq ID 19

<400>  20
atcaccaaca gcggcgatcg gatcaatacc gtgcgcggtc ctatcacaat ctctgaagcg       60

ggtttcacac tgactcacga gcacatctgc ggcagctcgg caggattctt gcgtgcttgg      120

ccggagttct tcggtagccg cgcagcccta gtggaaaagg ctgtgagagg attgcgccgc      180

gccagagcgg ctggcgtgcg aacgattgtc gatgtgtcga ctttcgatat cggtcgcgat      240

gtcagtttat tggccgaggt ttcgcgggct gccgacgttc atatcgtggc ggcgaccggc      300

ttgtgggagg acccgccact ttcgatgcgg ttgaggagtg tagaggaact cacacagttc      360

ttcctgcgtg agattcaata tggcatcgaa gacaccggaa ttagggcggg cattatcaag      420

gtcgcgacca atggcaaggc gacccccttt caggagttag tgttaagggc ggccgcccgg      480

gccagcttgg ccaccggtgt tccggtaacc actcacacgt tggcaagtca gcgcgatggt      540

gagcagcagg ccgccatttt tgagtccgaa ggcttgagcc cctcacgagt ttgtattggt      600

cacagcgatg atactgacga tttgagctat ctcaccgccc tcgctgcgcg cggatacctc      660

atcggtctag acggcatccc gcacagtgcg attggtctag aagataatgc gagtgcatca      720

gccctcctgg gcaaccgttc gtggcaaaca cgggctctct tgatcaaggc gctcatcgac      780

caaggctaca tgaaacaaat cctcgtttcg aatgactggc tgttcgggtt ttcgagctgg      840

gtcaccaaca tcatggacgt gatggatagc gtgaaccccg acgggatggc cttcattcca      900

ctgagagtga tcccattcct acgagagaag ggcgtctcac aggaaacgct ggcaggcatc      960

actgtgacca acccggcgcg gttcttgtca ccgaccttgc gggcgtcatg a              1011


<210>  21
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  genetically modified polypeptide

<400>  21

Ile Thr Asn Ser Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr 
1               5                   10                  15      


Ile Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser 
            20                  25                  30          


Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala 
        35                  40                  45              


Ala Leu Val Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala 
    50                  55                  60                  


Gly Val Arg Thr Ile Val Asp Val Ser Thr Phe Asp Ala Gly Arg Asp 
65                  70                  75                  80  


Val Ser Leu Leu Ala Glu Val Ser Arg Ala Ala Asp Val His Ile Val 
                85                  90                  95      


Ala Ala Thr Gly Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg 
            100                 105                 110         


Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly 
        115                 120                 125             


Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn 
    130                 135                 140                 


Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg 
145                 150                 155                 160 


Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Ala Ala Ser 
                165                 170                 175     


Gln Arg Asp Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         


Ser Pro Ser Arg Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu 
        195                 200                 205             


Ser Tyr Leu Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp 
    210                 215                 220                 


Gly Ile Pro His Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser 
225                 230                 235                 240 


Ala Leu Leu Gly Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys 
                245                 250                 255     


Ala Leu Ile Asp Gln Gly Tyr Met Lys Gln Ile Leu Val Ser Asn Asp 
            260                 265                 270         


Trp Leu Phe Gly Phe Ser Ser Tyr Val Thr Asn Ile Met Asp Val Met 
        275                 280                 285             


Asp Ser Val Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile 
    290                 295                 300                 


Pro Phe Leu Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Gly Ile 
305                 310                 315                 320 


Thr Val Thr Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330                 335     


<210>  22
<211>  1011
<212>  DNA
<213>  Artificial sequence

<220>
<223>  polynucleotide sequence encoding seq ID 21

<400>  22
atcaccaaca gcggcgatcg gatcaatacc gtgcgcggtc ctatcacaat ctctgaagcg       60

ggtttcacac tgactcacga gcacatctgc ggcagctcgg caggattctt gcgtgcttgg      120

ccggagttct tcggtagccg cgcagcccta gtggaaaagg ctgtgagagg attgcgccgc      180

gccagagcgg ctggcgtgcg aacgattgtc gatgtgtcga ctttcgatgc cggtcgcgat      240

gtcagtttat tggccgaggt ttcgcgggct gccgacgttc atatcgtggc ggcgaccggc      300

ttgtgggagg acccgccact ttcgatgcgg ttgaggagtg tagaggaact cacacagttc      360

ttcctgcgtg agattcaata tggcatcgaa gacaccggaa ttagggcggg cattatcaag      420

gtcgcgacca atggcaaggc gacccccttt caggagttag tgttaagggc ggccgcccgg      480

gccagcttgg ccaccggtgt tccggtaacc actcacacgg cagcaagtca gcgcgatggt      540

gagcagcagg ccgccatttt tgagtccgaa ggcttgagcc cctcacgagt ttgtattggt      600

cacagcgatg atactgacga tttgagctat ctcaccgccc tcgctgcgcg cggatacctc      660

atcggtctag acggcatccc gcacagtgcg attggtctag aagataatgc gagtgcatca      720

gccctcctgg gcaaccgttc gtggcaaaca cgggctctct tgatcaaggc gctcatcgac      780

caaggctaca tgaaacaaat cctcgtttcg aatgactggc tgttcgggtt ttcgagctat      840

gtcaccaaca tcatggacgt gatggatagc gtgaaccccg acgggatggc cttcattcca      900

ctgagagtga tcccattcct acgagagaag ggcgtcccac aggaaacgct ggcaggcatc      960

actgtgacca acccggcgcg gttcttgtca ccgaccttgc gggcgtcatg a              1011


<210>  23
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  genetically modified polypeptide

<400>  23

Ile Thr Asn Ser Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr 
1               5                   10                  15      


Ile Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser 
            20                  25                  30          


Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala 
        35                  40                  45              


Ala Leu Val Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala 
    50                  55                  60                  


Gly Val Arg Thr Ile Val Asp Val Ser Thr Phe Asp Ala Gly Arg Asp 
65                  70                  75                  80  


Val Ser Leu Leu Ala Glu Val Ser Arg Ala Ala Asp Val His Ile Val 
                85                  90                  95      


Ala Ala Thr Gly Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg 
            100                 105                 110         


Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly 
        115                 120                 125             


Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn 
    130                 135                 140                 


Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg 
145                 150                 155                 160 


Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Leu Ala Ser 
                165                 170                 175     


Gln Arg Asp Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         


Ser Pro Ser Arg Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu 
        195                 200                 205             


Ser Tyr Leu Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp 
    210                 215                 220                 


Gly Ile Pro His Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser 
225                 230                 235                 240 


Ala Leu Leu Gly Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys 
                245                 250                 255     


Ala Leu Ile Asp Gln Gly Tyr Met Lys Gln Ile Leu Val Ser Asn Asp 
            260                 265                 270         


Trp Leu Phe Gly Phe Ser Ser Tyr Val Thr Asn Ile Met Asp Val Met 
        275                 280                 285             


Asp Ser Val Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile 
    290                 295                 300                 


Pro Phe Leu Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Gly Ile 
305                 310                 315                 320 


Thr Val Thr Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330                 335     


<210>  24
<211>  1011
<212>  DNA
<213>  Artificial sequence

<220>
<223>  polynucleotide sequence encoding seq ID 23

<400>  24
atcaccaaca gcggcgatcg gatcaatacc gtgcgcggtc ctatcacaat ctctgaagcg       60

ggtttcacac tgactcacga gcacatctgc ggcagctcgg caggattctt gcgtgcttgg      120

ccggagttct tcggtagccg cgcagcccta gtggaaaagg ctgtgagagg attgcgccgc      180

gccagagcgg ctggcgtgcg aacgattgtc gatgtgtcga ctttcgatgc cggtcgcgat      240

gtcagtttat tggccgaggt ttcgcgggct gccgacgttc atatcgtggc ggcgaccggc      300

ttgtgggagg acccgccact ttcgatgcgg ttgaggagtg tagaggaact cacacagttc      360

ttcctgcgtg agattcaata tggcatcgaa gacaccggaa ttagggcggg cattatcaag      420

gtcgcgacca atggcaaggc gacccccttt caggagttag tgttaagggc ggccgcccgg      480

gccagcttgg ccaccggtgt tccggtaacc actcacacgt tggcaagtca gcgcgatggt      540

gagcagcagg ccgccatttt tgagtccgaa ggcttgagcc cctcacgagt ttgtattggt      600

cacagcgatg atactgacga tttgagctat ctcaccgccc tcgctgcgcg cggatacctc      660

atcggtctag acggcatccc gcacagtgcg attggtctag aagataatgc gagtgcatca      720

gccctcctgg gcaaccgttc gtggcaaaca cgggctctct tgatcaaggc gctcatcgac      780

caaggctaca tgaaacaaat cctcgtttcg aatgactggc tgttcgggtt ttcgagctat      840

gtcaccaaca tcatggacgt gatggatagc gtgaaccccg acgggatggc cttcattcca      900

ctgagagtga tcccattcct acgagagaag ggcgtcccac aggaaacgct ggcaggcatc      960

actgtgacca acccggcgcg gttcttgtca ccgaccttgc gggcgtcatg a              1011


<210>  25
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  genetically modified polypeptide

<400>  25

Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr Ile Ser Glu Leu 
1               5                   10                  15      


Gly Phe Thr Leu Met His Glu His Ile Cys Gly Ser Ser Ala Gly Phe 
            20                  25                  30          


Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala Ala Leu Val Glu 
        35                  40                  45              


Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala Gly Val Asp Thr 
    50                  55                  60                  


Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp Val Glu Leu Leu 
65                  70                  75                  80  


Ala Glu Val Ala Glu Ala Ala Asp Val His Ile Val Ala Ala Thr Gly 
                85                  90                  95      


Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg Ser Val Glu Glu 
            100                 105                 110         


Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp Thr 
        115                 120                 125             


Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn Gly Lys Ala Thr 
    130                 135                 140                 


Pro Phe Gln Glu Arg Val Leu Arg Ala Ala Ala Arg Ala Ser Leu Glu 
145                 150                 155                 160 


Thr Gly Val Pro Val Thr Thr His Thr Asp Ala Ser Gln Arg Asp Gly 
                165                 170                 175     


Glu Glu Gln Ala Asp Ile Phe Glu Ser Glu Gly Leu Asp Pro Ser Arg 
            180                 185                 190         


Val Cys Ile Gly His Ala Asp Asp Thr Asp Asp Leu Asp Tyr Leu Thr 
        195                 200                 205             


Glu Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp Gly Ile Pro His 
    210                 215                 220                 


Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ala Ala Leu Leu Gly 
225                 230                 235                 240 


Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp 
                245                 250                 255     


Gln Gly Tyr Ala Asp Gln Ile Leu Val Ser Asn Asp Trp Leu Phe Gly 
            260                 265                 270         


Phe Ser Ser Trp Val Thr Asn Ile Met Asp Val Met Asp Ser Val Asn 
        275                 280                 285             


Pro Asp Gly Met Ala His Ile Pro Glu Arg Val Ile Pro Phe Leu Arg 
    290                 295                 300                 


Glu Lys Gly Val Pro Asp Glu Thr Leu Asp Thr Ile Met Val Glu Asn 
305                 310                 315                 320 


Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330         


<210>  26
<211>  1049
<212>  DNA
<213>  Artificial sequence

<220>
<223>  polynucleotide sequence encoding seq ID 25

<400>  26
ggaaggattt cagaattcat caccaacagc ggcgaccgta tcaacaccgt tcgtggtccg       60

atcaccatct ctgagctggg tttcaccctg atgcacgaac acatctgcgg ttcttctgcg      120

ggtttcctgc gcgcgtggcc ggaatttttc ggttctcgtg cggcgctggt tgagaaagcg      180

gttcgcggtc tgcgtcgtgc ccgtgctgct ggtgtcgata ccatcgttga cgtttctacc      240

tttgatatcg gtcgtgacgt tgaactgctg gcggaggttg ccgaggcagc ggacgttcac      300

atcgtagctg ccaccggtct gtgggaagac ccaccgctgt ctatgcgtct gcgctctgtt      360

gaagaactga cccaattctt cctccgtgag atccagtacg gtattgagga caccggtatc      420

cgtgcgggta tcatcaaagt tgcgaccaac ggtaaagcga ccccgttcca ggaacgcgta      480

ctccgtgccg ctgcgcgtgc gtctctggaa actggtgtac cggttactac ccacaccgac      540

gcctctcagc gtgacggtga agagcaagcg gacatctttg agtctgaagg cctggacccg      600

tctcgcgttt gcatcggtca cgcggacgat accgacgacc tggactatct gacggaactg      660

gcggctcgcg gctacctgat tggtctggac ggcatcccgc actctgcgat cggcctcgaa      720

gacaacgctt ctgctgccgc cctcctgggt aatcgttctt ggcagactcg tgctctgctg      780

atcaaagcgc tgatcgacca gggctatgcg gaccagatcc tggtttctaa cgactggctg      840

ttcggtttct cttcttgggt taccaacatt atggacgtta tggattctgt taacccggac      900

ggtatggcgc acatccctga acgtgtgatc ccgtttctgc gtgaaaaagg tgttccggac      960

gaaaccctgg acaccatcat ggtagagaac ccggcacgtt ttctctctcc gacgctccgc     1020

gcgtcttgat aactgcaggc aagcttggc                                       1049


<210>  27
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  genetically modified polypeptide

<400>  27

Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr Ile Ser Glu Ala 
1               5                   10                  15      


Gly Phe Thr Leu Met His Glu His Ile Cys Gly Ser Ser Ala Gly Phe 
            20                  25                  30          


Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala Ala Leu Val Glu 
        35                  40                  45              


Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala Gly Val Arg Thr 
    50                  55                  60                  


Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp Val Glu Leu Leu 
65                  70                  75                  80  


Ala Glu Val Ser Glu Ala Ala Asp Val His Ile Val Ala Ala Thr Gly 
                85                  90                  95      


Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg Ser Val Glu Glu 
            100                 105                 110         


Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp Thr 
        115                 120                 125             


Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn Gly Lys Ala Thr 
    130                 135                 140                 


Pro Phe Gln Glu Arg Val Leu Arg Ala Ala Ala Arg Ala Ser Leu Ala 
145                 150                 155                 160 


Thr Gly Val Pro Val Thr Thr His Thr Asp Ala Ser Gln Arg Asp Gly 
                165                 170                 175     


Glu Gln Gln Ala Asp Ile Phe Glu Ser Glu Gly Leu Asp Pro Ser Arg 
            180                 185                 190         


Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu Asp Tyr Leu Thr 
        195                 200                 205             


Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp Gly Ile Pro His 
    210                 215                 220                 


Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ala Ala Leu Leu Gly 
225                 230                 235                 240 


Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp 
                245                 250                 255     


Gln Gly Tyr Ala Asp Gln Ile Leu Val Ser Asn Asp Trp Leu Phe Gly 
            260                 265                 270         


Phe Ser Ser Trp Val Thr Asn Ile Met Asp Val Met Asp Ser Val Asn 
        275                 280                 285             


Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile Pro Phe Leu Arg 
    290                 295                 300                 


Glu Lys Gly Val Pro Asp Glu Thr Leu Glu Thr Ile Met Val Asp Asn 
305                 310                 315                 320 


Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330         


<210>  28
<211>  1049
<212>  DNA
<213>  Artificial sequence

<220>
<223>  polynucleotide sequence encoding seq ID 27

<400>  28
ggaaggattt cagaattcat caccaacagc ggcgaccgta tcaacaccgt acgtggtccg       60

atcaccatct ccgaagcggg tttcaccctg atgcacgaac acatctgcgg ttcttctgcg      120

ggcttcctcc gcgcttggcc ggagttcttt ggttctcgcg ctgctctggt tgaaaaagcg      180

gttcgtggtc tgcgtcgtgc tcgtgctgcc ggtgtgcgta ccatcgttga cgtttctacc      240

ttcgacattg gccgcgatgt cgagctgctc gccgaagttt ctgaagcggc ggacgttcat      300

attgttgcgg caaccggtct gtgggaggac cctccgctgt ctatgcgcct ccgttctgtt      360

gaagagctca cccagttttt tctccgcgaa atccagtacg gtatcgaaga cactggtatc      420

cgtgcgggta tcatcaaagt tgcgaccaac ggtaaagcaa ccccgttcca ggaacgtgtt      480

ctccgtgcag cagcccgtgc gtctctggcg accggcgttc cggtcaccac ccacaccgac      540

gcttctcagc gtgacggtga acagcaggcg gacatcttcg aatctgaagg cctcgacccg      600

tctcgtgttt gcatcggtca ttctgatgac acggacgacc tggactacct gaccgcgctg      660

gccgctcgtg gttatctcat tggtctggac ggcattccgc attctgcgat cggcctggaa      720

gacaacgcgt ctgcggctgc actgctgggt aaccgttctt ggcagacccg tgccctgctg      780

atcaaagcgc tgatcgacca gggttacgcg gaccagatcc tggtttctaa cgactggctg      840

ttcggtttct cttcttgggt taccaacatc atggacgtta tggactctgt taacccggac      900

ggtatggcgt tcatcccact ccgtgtgatc ccttttctgc gtgagaaggg tgttccggat      960

gaaactctgg agacgattat ggttgacaac ccggcacgtt ttctgtctcc gactctgcgc     1020

gcgtcttgat aactgcaggc aagcttggc                                       1049


<210>  29
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  genetically modified polypeptide

<400>  29

Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr Ile Ser Glu Ala 
1               5                   10                  15      


Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser Ser Ala Gly Phe 
            20                  25                  30          


Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala Ala Leu Val Glu 
        35                  40                  45              


Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala Gly Val Arg Thr 
    50                  55                  60                  


Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp Val Ser Leu Leu 
65                  70                  75                  80  


Ala Glu Val Ser Glu Ala Ala Asp Val His Ile Val Ala Ala Thr Gly 
                85                  90                  95      


Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg Ser Val Glu Glu 
            100                 105                 110         


Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp Thr 
        115                 120                 125             


Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn Gly Lys Ala Thr 
    130                 135                 140                 


Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg Ala Ser Leu Ala 
145                 150                 155                 160 


Thr Gly Val Pro Val Thr Thr His Thr Asp Ala Ser Gln Arg Asp Gly 
                165                 170                 175     


Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu Asp Pro Ser Arg 
            180                 185                 190         


Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu Asp Tyr Leu Thr 
        195                 200                 205             


Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp Gly Ile Pro His 
    210                 215                 220                 


Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser Ala Leu Leu Gly 
225                 230                 235                 240 


Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp 
                245                 250                 255     


Gln Gly Tyr Val Lys Gln Ile Leu Val Ser Asn Asp Trp Leu Phe Gly 
            260                 265                 270         


Phe Ser Ser Trp Val Thr Asn Ile Met Asp Val Met Asp Ser Val Asn 
        275                 280                 285             


Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile Pro Phe Leu Arg 
    290                 295                 300                 


Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Thr Ile Thr Val Glu Asn 
305                 310                 315                 320 


Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330         


<210>  30
<211>  1049
<212>  DNA
<213>  Artificial sequence

<220>
<223>  polynucleotide sequence encoding seq ID 29

<400>  30
ggaaggattt cagaattcat caccaacagc ggcgaccgta tcaacaccgt ccgtggtccg       60

atcaccatct ctgaggcggg cttcaccctg actcacgaac acatttgcgg ttctagcgca      120

ggttttctgc gcgcttggcc ggagtttttc ggttctcgtg ctgctctggt ggaaaaagcg      180

gttcgtggcc tgcgtcgtgc gcgtgcggct ggtgtgcgta ccatcgttga cgtttctacc      240

ttcgacattg gtcgtgatgt ttctctgctg gccgaggttt ctgaagcggc cgatgttcac      300

attgttgcag cgactggtct gtgggaagat ccgccgctgt ctatgcgtct gcgctctgtt      360

gaagaactca cccagttctt tctccgtgaa atccagtacg gcatcgagga cacgggtatc      420

cgtgccggta tcattaaagt tgccaccaac ggtaaagcga ccccgtttca ggaactggtt      480

ctgcgtgcag cagctcgtgc ctccctcgcc accggcgttc cggtcaccac ccacaccgac      540

gcttctcagc gtgacggtga acagcaggcg gcgatcttcg aaagcgaagg tctggacccg      600

tctcgtgttt gtatcggtca ctctgacgac accgatgatc tggactacct gaccgcgctc      660

gcggctcgtg gttacctgat tggcctggat ggtattccgc actctgcgat cggcctcgaa      720

gacaacgcat ctgcgtccgc tctgctcggt aatcgctctt ggcagacccg tgcgctgctg      780

atcaaagcgc tgatcgacca gggctacgtt aaacagatcc tggtttctaa cgattggctg      840

ttcggttttt cttcttgggt taccaacatc atggacgtta tggactctgt taacccagac      900

ggtatggcgt tcatcccgct gcgtgttatc ccgttcctgc gcgagaaagg tgttccacaa      960

gagacgctgg cgaccatcac cgttgaaaac cctgctcgtt tcctgtctcc aaccctccgt     1020

gcttcttgat aactgcaggc aagcttggc                                       1049


<210>  31
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  genetically modified polypeptide

<400>  31

Ile Thr Asn Ser Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr 
1               5                   10                  15      


Ile Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser 
            20                  25                  30          


Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala 
        35                  40                  45              


Ala Leu Val Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala 
    50                  55                  60                  


Gly Val Arg Thr Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp 
65                  70                  75                  80  


Val Ser Leu Leu Ala Glu Val Ser Glu Ala Ala Asp Val His Ile Val 
                85                  90                  95      


Ala Ala Thr Gly Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg 
            100                 105                 110         


Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly 
        115                 120                 125             


Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn 
    130                 135                 140                 


Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg 
145                 150                 155                 160 


Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Asp Ala Ser 
                165                 170                 175     


Gln Arg Asp Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         


Asp Pro Ser Arg Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu 
        195                 200                 205             


Asp Tyr Leu Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp 
    210                 215                 220                 


Gly Ile Pro His Ser Ala Ile Gly Leu Glu Asp Asn Ala Met Ala Ser 
225                 230                 235                 240 


Ser Trp Leu Gly Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys 
                245                 250                 255     


Ala Leu Ile Asp Gln Gly Tyr Val Lys Gln Ile Leu Val Ser Asn Asp 
            260                 265                 270         


Trp Leu Phe Gly Phe Ser Ser Trp Val Thr Asn Ile Met Asp Val Met 
        275                 280                 285             


Asp Ser Val Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile 
    290                 295                 300                 


Pro Phe Leu Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Thr Ile 
305                 310                 315                 320 


Thr Val Glu Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330                 335     


<210>  32
<211>  1011
<212>  DNA
<213>  Artificial sequence

<220>
<223>  polynucleotide sequence encoding seq ID 31

<400>  32
atcaccaaca gcggcgaccg tatcaacacc gtccgtggtc cgatcaccat ctctgaggcg       60

ggcttcaccc tgactcacga acacatttgc ggttctagcg caggttttct gcgcgcttgg      120

ccggagtttt tcggttctcg tgctgctctg gtggaaaaag cggttcgtgg cctgcgtcgt      180

gcgcgtgcgg ctggtgtgcg taccatcgtt gacgtttcta ccttcgacat tggtcgtgat      240

gtttctctgc tggccgaggt ttctgaagcg gccgatgttc acattgttgc agcgactggt      300

ctgtgggaag atccgccgct gtctatgcgt ctgcgctctg ttgaagaact cacccagttc      360

tttctccgtg aaatccagta cggcatcgag gacacgggta tccgtgccgg tatcattaaa      420

gttgccacca acggtaaagc gaccccgttt caggaactgg ttctgcgtgc agcagctcgt      480

gcctccctcg ccaccggcgt tccggtcacc acccacaccg acgcttctca gcgtgacggt      540

gaacagcagg cggcgatctt cgaaagcgaa ggtctggacc cgtctcgtgt ttgtatcggt      600

cactctgacg acaccgatga tctggactac ctgaccgcgc tcgcggctcg tggttacctg      660

attggcctgg atggtattcc gcactctgcg atcggcctcg aagacaacgc aatggcgtcc      720

agctggctcg gtaatcgctc ttggcagacc cgtgcgctgc tgatcaaagc gctgatcgac      780

cagggctacg ttaaacagat cctggtttct aacgattggc tgttcggttt ttcttcttgg      840

gttaccaaca tcatggacgt tatggactct gttaacccag acggtatggc gttcatcccg      900

ctgcgtgtta tcccgttcct gcgcgagaaa ggtgttccac aagagacgct ggcgaccatc      960

accgttgaaa accctgctcg tttcctgtct ccaaccctcc gtgcttcttg a              1011


<210>  33
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  genetically modified polypeptide

<400>  33

Ile Thr Asn Ser Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr 
1               5                   10                  15      


Ile Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser 
            20                  25                  30          


Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala 
        35                  40                  45              


Ala Leu Val Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala 
    50                  55                  60                  


Gly Val Arg Thr Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp 
65                  70                  75                  80  


Val Ser Leu Leu Ala Glu Val Ser Glu Ala Ala Asp Val His Ile Val 
                85                  90                  95      


Ala Ala Thr Gly Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg 
            100                 105                 110         


Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly 
        115                 120                 125             


Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn 
    130                 135                 140                 


Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg 
145                 150                 155                 160 


Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Asp Ala Ser 
                165                 170                 175     


Gln Arg Asp Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         


Asp Pro Ser Arg Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu 
        195                 200                 205             


Asp Tyr Leu Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp 
    210                 215                 220                 


Gly Ile Pro His Ser Ala Ile Gly Leu Glu Asp Asn Ala Arg Ala Ser 
225                 230                 235                 240 


Ser Trp Leu Gly Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys 
                245                 250                 255     


Ala Leu Ile Asp Gln Gly Tyr Val Lys Gln Ile Leu Val Ser Asn Asp 
            260                 265                 270         


Trp Leu Phe Gly Phe Ser Ser Trp Val Thr Asn Ile Met Asp Val Met 
        275                 280                 285             


Asp Ser Val Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile 
    290                 295                 300                 


Pro Phe Leu Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Thr Ile 
305                 310                 315                 320 


Thr Val Glu Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330                 335     


<210>  34
<211>  1011
<212>  DNA
<213>  Artificial sequence

<220>
<223>  polynucleotide sequence encoding seq ID 33

<400>  34
atcaccaaca gcggcgaccg tatcaacacc gtccgtggtc cgatcaccat ctctgaggcg       60

ggcttcaccc tgactcacga acacatttgc ggttctagcg caggttttct gcgcgcttgg      120

ccggagtttt tcggttctcg tgctgctctg gtggaaaaag cggttcgtgg cctgcgtcgt      180

gcgcgtgcgg ctggtgtgcg taccatcgtt gacgtttcta ccttcgacat tggtcgtgat      240

gtttctctgc tggccgaggt ttctgaagcg gccgatgttc acattgttgc agcgactggt      300

ctgtgggaag atccgccgct gtctatgcgt ctgcgctctg ttgaagaact cacccagttc      360

tttctccgtg aaatccagta cggcatcgag gacacgggta tccgtgccgg tatcattaaa      420

gttgccacca acggtaaagc gaccccgttt caggaactgg ttctgcgtgc agcagctcgt      480

gcctccctcg ccaccggcgt tccggtcacc acccacaccg acgcttctca gcgtgacggt      540

gaacagcagg cggcgatctt cgaaagcgaa ggtctggacc cgtctcgtgt ttgtatcggt      600

cactctgacg acaccgatga tctggactac ctgaccgcgc tcgcggctcg tggttacctg      660

attggcctgg atggtattcc gcactctgcg atcggcctcg aagacaacgc aagggcgtcc      720

agctggctcg gtaatcgctc ttggcagacc cgtgcgctgc tgatcaaagc gctgatcgac      780

cagggctacg ttaaacagat cctggtttct aacgattggc tgttcggttt ttcttcttgg      840

gttaccaaca tcatggacgt tatggactct gttaacccag acggtatggc gttcatcccg      900

ctgcgtgtta tcccgttcct gcgcgagaaa ggtgttccac aagagacgct ggcgaccatc      960

accgttgaaa accctgctcg tttcctgtct ccaaccctcc gtgcttcttg a              1011


<210>  35
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  genetically modified polypeptide

<400>  35

Ile Thr Asn Ser Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr 
1               5                   10                  15      


Ile Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser 
            20                  25                  30          


Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala 
        35                  40                  45              


Ala Leu Val Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala 
    50                  55                  60                  


Gly Val Arg Thr Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp 
65                  70                  75                  80  


Val Ser Leu Leu Ala Glu Val Ser Glu Ala Ala Asp Val His Ile Val 
                85                  90                  95      


Ala Ala Thr Gly Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg 
            100                 105                 110         


Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly 
        115                 120                 125             


Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn 
    130                 135                 140                 


Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg 
145                 150                 155                 160 


Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Asp Ala Ser 
                165                 170                 175     


Gln Arg Asp Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         


Asp Pro Ser Arg Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu 
        195                 200                 205             


Asp Tyr Leu Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp 
    210                 215                 220                 


Gly Ile Pro His Ser Ala Ile Gly Leu Glu Asp Asn Ala Arg Ala Ser 
225                 230                 235                 240 


Asp Trp Leu Gly Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys 
                245                 250                 255     


Ala Leu Ile Asp Gln Gly Tyr Val Lys Gln Ile Leu Val Ser Asn Asp 
            260                 265                 270         


Trp Leu Phe Gly Phe Ser Ser Trp Val Thr Asn Ile Met Asp Val Met 
        275                 280                 285             


Asp Ser Val Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile 
    290                 295                 300                 


Pro Phe Leu Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Thr Ile 
305                 310                 315                 320 


Thr Val Glu Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330                 335     


<210>  36
<211>  1011
<212>  DNA
<213>  Artificial sequence

<220>
<223>  polynucleotide sequence encoding seq ID 35

<400>  36
atcaccaaca gcggcgaccg tatcaacacc gtccgtggtc cgatcaccat ctctgaggcg       60

ggcttcaccc tgactcacga acacatttgc ggttctagcg caggttttct gcgcgcttgg      120

ccggagtttt tcggttctcg tgctgctctg gtggaaaaag cggttcgtgg cctgcgtcgt      180

gcgcgtgcgg ctggtgtgcg taccatcgtt gacgtttcta ccttcgacat tggtcgtgat      240

gtttctctgc tggccgaggt ttctgaagcg gccgatgttc acattgttgc agcgactggt      300

ctgtgggaag atccgccgct gtctatgcgt ctgcgctctg ttgaagaact cacccagttc      360

tttctccgtg aaatccagta cggcatcgag gacacgggta tccgtgccgg tatcattaaa      420

gttgccacca acggtaaagc gaccccgttt caggaactgg ttctgcgtgc agcagctcgt      480

gcctccctcg ccaccggcgt tccggtcacc acccacaccg acgcttctca gcgtgacggt      540

gaacagcagg cggcgatctt cgaaagcgaa ggtctggacc cgtctcgtgt ttgtatcggt      600

cactctgacg acaccgatga tctggactac ctgaccgcgc tcgcggctcg tggttacctg      660

attggcctgg atggtattcc gcactctgcg atcggcctcg aagacaacgc aagggcgtcc      720

gattggctcg gtaatcgctc ttggcagacc cgtgcgctgc tgatcaaagc gctgatcgac      780

cagggctacg ttaaacagat cctggtttct aacgattggc tgttcggttt ttcttcttgg      840

gttaccaaca tcatggacgt tatggactct gttaacccag acggtatggc gttcatcccg      900

ctgcgtgtta tcccgttcct gcgcgagaaa ggtgttccac aagagacgct ggcgaccatc      960

accgttgaaa accctgctcg tttcctgtct ccaaccctcc gtgcttcttg a              1011


