                         SEQUENCE LISTING

<110>  MeMed Diagnostics Ltd.
       OVED, Kfir
       EDEN, Eran
 
<120>  MARKER COMBINATIONS FOR DIAGNOSING INFECTIONS AND METHODS OF USE 
       THEREOF

<130>  64273

<150>  US 62/090,606
<151>  2014-12-11

<150>  US 62/136,725
<151>  2015-03-23

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Lys Leu Leu Cys Phe Leu Val Leu Thr Ser Leu Ser His Ala 
1               5                   10                  15      


Phe Gly Gln Thr Asp Met Ser Arg Lys Ala Phe Val Phe Pro Lys Glu 
            20                  25                  30          


Ser Asp Thr Ser Tyr Val Ser Leu Lys Ala Pro Leu Thr Lys Pro Leu 
        35                  40                  45              


Lys Ala Phe Thr Val Cys Leu His Phe Tyr Thr Glu Leu Ser Ser Thr 
    50                  55                  60                  


Arg Gly Tyr Ser Ile Phe Ser Tyr Ala Thr Lys Arg Gln Asp Asn Glu 
65                  70                  75                  80  


Ile Leu Ile Phe Trp Ser Lys Asp Ile Gly Tyr Ser Phe Thr Val Gly 
                85                  90                  95      


Gly Ser Glu Ile Leu Phe Glu Val Pro Glu Val Thr Val Ala Pro Val 
            100                 105                 110         


His Ile Cys Thr Ser Trp Glu Ser Ala Ser Gly Ile Val Glu Phe Trp 
        115                 120                 125             


Val Asp Gly Lys Pro Arg Val Arg Lys Ser Leu Lys Lys Gly Tyr Thr 
    130                 135                 140                 


Val Gly Ala Glu Ala Ser Ile Ile Leu Gly Gln Glu Gln Asp Ser Phe 
145                 150                 155                 160 


Gly Gly Asn Phe Glu Gly Ser Gln Ser Leu Val Gly Asp Ile Gly Asn 
                165                 170                 175     


Val Asn Met Trp Asp Phe Val Leu Ser Pro Asp Glu Ile Asn Thr Ile 
            180                 185                 190         


Tyr Leu Gly Gly Pro Phe Ser Pro Asn Val Leu Asn Trp Arg Ala Leu 
        195                 200                 205             


Lys Tyr Glu Val Gln Gly Glu Val Phe Thr Lys Pro Gln Leu Trp Pro 
    210                 215                 220                 


<210>  2
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequences of soluble TRAIL

<400>  2

Thr Ser Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile 
1               5                   10                  15      


Ser Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile 
            20                  25                  30          


Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
        35                  40                  45              


Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
    50                  55                  60                  


Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
65                  70                  75                  80  


Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
                85                  90                  95      


Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
            100                 105                 110         


Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
        115                 120                 125             


Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
    130                 135                 140                 


Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
145                 150                 155                 160 


Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
                165                 170                 175     


Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
            180                 185         


<210>  3
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequences of soluble TRAIL

<400>  3

Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr 
1               5                   10                  15      


Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 
            20                  25                  30          


Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 
        35                  40                  45              


Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 
    50                  55                  60                  


Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 
65                  70                  75                  80  


Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 
                85                  90                  95      


Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 
            100                 105                 110         


Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 
        115                 120                 125             


Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 
    130                 135                 140                 


Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 
145                 150                 155                 160 


Phe Phe Gly Ala Phe Leu Val Gly 
                165             


<210>  4
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asn Gln Thr Ala Ile Leu Ile Cys Cys Leu Ile Phe Leu Thr Leu 
1               5                   10                  15      


Ser Gly Ile Gln Gly Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys 
            20                  25                  30          


Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser Lys Arg 
                85                  90                  95      


Ser Pro 
        


<210>  5
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequences of TRAILR3/ TNFRSF10C

<400>  5

Ala Arg Ile Pro Lys Thr Leu Lys Phe Val Val Val Ile Val Ala Val 
1               5                   10                  15      


Leu Leu Pro Val Leu Ala Tyr Ser Ala Thr Thr Ala Arg Gln Glu Glu 
            20                  25                  30          


Val Pro Gln Gln Thr Val Ala Pro Gln Gln Gln Arg His Ser Phe Lys 
        35                  40                  45              


Gly Glu Glu Cys Pro Ala Gly Ser His Arg Ser Glu His Thr Gly Ala 
    50                  55                  60                  


Cys Asn Pro Cys Thr Glu Gly Val Asp Tyr Thr Asn Ala Ser Asn Asn 
65                  70                  75                  80  


Glu Pro Ser Cys Phe Pro Cys Thr Val Cys Lys Ser Asp Gln Lys His 
                85                  90                  95      


Lys Ser Ser Cys Thr Met Thr Arg Asp Thr Val Cys Gln Cys Lys Glu 
            100                 105                 110         


Gly Thr Phe Arg Asn Glu Asn Ser Pro Glu Met Cys Arg Lys Cys Ser 
        115                 120                 125             


Arg Cys Pro Ser Gly Glu Val Gln Val Ser Asn Cys Thr Ser Trp Asp 
    130                 135                 140                 


Asp Ile Gln Cys Val Glu Glu Phe Gly Ala Asn Ala Thr Val Glu Thr 
145                 150                 155                 160 


Pro Ala Ala Glu Glu Thr Met Asn Thr Ser Pro Gly Thr Pro Ala Pro 
                165                 170                 175     


Ala Ala Glu Glu Thr Met Asn Thr Ser Pro Gly Thr Pro Ala Pro Ala 
            180                 185                 190         


Ala Glu Glu Thr Met Thr Thr Ser Pro Gly Thr Pro Ala Pro Ala Ala 
        195                 200                 205             


Glu Glu Thr Met Thr Thr Ser Pro Gly Thr Pro Ala Pro Ala Ala Glu 
    210                 215                 220                 


Glu Thr Met Thr Thr Ser Pro Gly Thr Pro Ala Ser Ser His Tyr Leu 
225                 230                 235                 240 


Ser Cys Thr Ile Val Gly Ile Ile Val Leu Ile Val Leu Leu Ile Val 
                245                 250                 255     


Phe Val 
        


<210>  6
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequences of TRAILR3/ TNFRSF10C

<400>  6

Met Ala Arg Ile Pro Lys Thr Leu Lys Phe Val Val Val Ile Val Ala 
1               5                   10                  15      


Val Leu Leu Pro Val Leu Ala Tyr Ser Ala Thr Thr Ala Arg Gln Glu 
            20                  25                  30          


Glu Val Pro Gln Gln Thr Val Ala Pro Gln Gln Gln Arg His Ser Phe 
        35                  40                  45              


Lys Gly Glu Glu Cys Pro Ala Gly Ser His Arg Ser Glu His Thr Gly 
    50                  55                  60                  


Ala Cys Asn Pro Cys Thr Glu Gly Val Asp Tyr Thr Asn Ala Ser Asn 
65                  70                  75                  80  


Asn Glu Pro Ser Cys Phe Pro Cys Thr Val Cys Lys Ser Asp Gln Lys 
                85                  90                  95      


His Lys Ser Ser Cys Thr Met Thr Arg Asp Thr Val Cys Gln Cys Lys 
            100                 105                 110         


Glu Gly Thr Phe Arg Asn Glu Asn Ser Pro Glu Met Cys Arg Lys Cys 
        115                 120                 125             


Ser Arg Cys Pro Ser Gly Glu Val Gln Val Ser Asn Cys Thr Ser Trp 
    130                 135                 140                 


Asp Asp Ile Gln Cys Val Glu Glu Phe Gly Ala Asn Ala Thr Val Glu 
145                 150                 155                 160 


Thr Pro Ala Ala Glu Glu Thr Met Asn Thr Ser Pro Gly Thr Pro Ala 
                165                 170                 175     


Pro Ala Ala Glu Glu Thr Met Asn Thr Ser Pro Gly Thr Pro Ala Pro 
            180                 185                 190         


Ala Ala Glu Glu Thr Met Thr Thr Ser Pro Gly Thr Pro Ala Pro Ala 
        195                 200                 205             


Ala Glu Glu Thr Met Thr Thr Ser Pro Gly Thr Pro Ala Pro Ala Ala 
    210                 215                 220                 


Glu Glu Thr Met Ile Thr Ser Pro Gly Thr Pro Ala Ser Ser His Tyr 
225                 230                 235                 240 


Leu Ser Cys Thr Ile Val Gly Ile Ile Val Leu Ile Val Leu Leu Ile 
                245                 250                 255     


Val Phe Val 
            


<210>  7
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequences of TRAILR4/ TNFRSF10D

<400>  7

Met Gly Leu Trp Gly Gln Ser Val Pro Thr Ala Ser Ser Ala Arg Ala 
1               5                   10                  15      


Gly Arg Tyr Pro Gly Ala Arg Thr Ala Ser Gly Thr Arg Pro Trp Leu 
            20                  25                  30          


Leu Asp Pro Lys Ile Leu Lys Phe Val Val Phe Ile Val Ala Val Leu 
        35                  40                  45              


Leu Pro Val Arg Val Asp Ser Ala Thr Ile Pro Arg Gln Asp Glu Val 
    50                  55                  60                  


Pro Gln Gln Thr Val Ala Pro Gln Gln Gln Arg Arg Ser Leu Lys Glu 
65                  70                  75                  80  


Glu Glu Cys Pro Ala Gly Ser His Arg Ser Glu Tyr Thr Gly Ala Cys 
                85                  90                  95      


Asn Pro Cys Thr Glu Gly Val Asp Tyr Thr Ile Ala Ser Asn Asn Leu 
            100                 105                 110         


Pro Ser Cys Leu Leu Cys Thr Val Cys Lys Ser Gly Gln Thr Asn Lys 
        115                 120                 125             


Ser Ser Cys Thr Thr Thr Arg Asp Thr Val Cys Gln Cys Glu Lys Gly 
    130                 135                 140                 


Ser Phe Gln Asp Lys Asn Ser Pro Glu Met Cys Arg Thr Cys Arg Thr 
145                 150                 155                 160 


Gly Cys Pro Arg Gly Met Val Lys Val Ser Asn Cys Thr Pro Arg Ser 
                165                 170                 175     


Asp Ile Lys Cys Lys Asn Glu Ser Ala Ala Ser Ser Gly Lys Thr Pro 
            180                 185                 190         


Ala Ala Glu Glu Thr Val Thr Thr Ile Leu Gly Met Leu Ala Ser Pro 
        195                 200                 205             


Tyr His Tyr Leu Ile Ile Ile Val Val Leu Val Ile Ile Leu Ala Val 
    210                 215                 220                 


Val Val Val Gly Phe Ser Cys Arg Lys Lys Phe Ile Ser Tyr Leu Lys 
225                 230                 235                 240 


Gly Ile Cys Ser Gly Gly Gly Gly Gly Pro Glu Arg Val His Arg Val 
                245                 250                 255     


Leu Phe Arg Arg Arg Ser Cys Pro Ser Arg Val Pro Gly Ala Glu Asp 
            260                 265                 270         


Asn Ala Arg Asn Glu Thr Leu Ser Asn Arg Tyr Leu Gln Pro Thr Gln 
        275                 280                 285             


Val Ser Glu Gln Glu Ile Gln Gly Gln Glu Leu Ala Glu Leu Thr Gly 
    290                 295                 300                 


Val Thr Val Glu Ser Pro Glu Glu Pro Gln Arg Leu Leu Glu Gln Ala 
305                 310                 315                 320 


Glu Ala Glu Gly Cys Gln Arg Arg Arg Leu Leu Val Pro Val Asn Asp 
                325                 330                 335     


Ala Asp Ser Ala Asp Ile Ser Thr Leu Leu Asp Ala Ser Ala Thr Leu 
            340                 345                 350         


Glu Glu Gly His Ala Lys Glu Thr Ile Gln Asp Gln Leu Val Gly Ser 
        355                 360                 365             


Glu Lys Leu Phe Tyr Glu Glu Asp Glu Ala Gly Ser Ala Thr Ser Cys 
    370                 375                 380                 


Leu 
385 


<210>  8
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequences of TRAILR4/ TNFRSF10D

<400>  8

Met Gly Leu Trp Gly Gln Ser Val Pro Thr Ala Ser Ser Ala Arg Ala 
1               5                   10                  15      


Gly Arg Tyr Pro Gly Ala Arg Thr Ala Ser Gly Thr Arg Pro Trp Leu 
            20                  25                  30          


Leu Asp Pro Lys Ile Leu Lys Phe Val Val Phe Ile Val Ala Val Leu 
        35                  40                  45              


Leu Pro Val Arg Val Asp Ser Ala Thr Ile Pro Arg Gln Asp Glu Val 
    50                  55                  60                  


Pro Gln Gln Thr Val Ala Pro Gln Gln Gln Arg Arg Ser Leu Lys Glu 
65                  70                  75                  80  


Glu Glu Cys Pro Ala Gly Ser His Arg Ser Glu Tyr Thr Gly Ala Cys 
                85                  90                  95      


Asn Pro Cys Thr Glu Gly Val Asp Tyr Thr Ile Ala Ser Asn Asn Leu 
            100                 105                 110         


Pro Ser Cys Leu Leu Cys Thr Val Cys Lys Ser Gly Gln Thr Asn Lys 
        115                 120                 125             


Ser Ser Cys Thr Thr Thr Arg Asp Thr Val Cys Gln Cys Glu Lys Gly 
    130                 135                 140                 


Ser Phe Gln Asp Lys Asn Ser Pro Glu Met Cys Arg Thr Cys Arg Thr 
145                 150                 155                 160 


Gly Cys Pro Arg Gly Met Val Lys Val Ser Asn Cys Thr Pro Arg Ser 
                165                 170                 175     


Asp Ile Lys Cys Lys Asn Glu Ser Ala Ala Ser Ser Thr Gly Lys Thr 
            180                 185                 190         


Pro Ala Ala Glu Glu Thr Val Thr Thr Ile Leu Gly Met Leu Ala Ser 
        195                 200                 205             


Pro Tyr His Tyr Leu Ile Ile Ile Val Val Leu Val Ile Ile Leu Ala 
    210                 215                 220                 


Val Val Val Val Gly Phe Ser Cys Arg Lys Lys Phe Ile Ser Tyr Leu 
225                 230                 235                 240 


Lys Gly Ile Cys Ser Gly Gly Gly Gly Gly Pro Glu Arg Val His Arg 
                245                 250                 255     


Val Leu Phe Arg Arg Arg Ser Cys Pro Ser Arg Val Pro Gly Ala Glu 
            260                 265                 270         


Asp Asn Ala Arg Asn Glu Thr Leu Ser Asn Arg Tyr Leu Gln Pro Thr 
        275                 280                 285             


Gln Val Ser Glu Gln Glu Ile Gln Gly Gln Glu Leu Ala Glu Leu Thr 
    290                 295                 300                 


Gly Val Thr Val Glu Leu Pro Glu Glu Pro Gln Arg Leu Leu Glu Gln 
305                 310                 315                 320 


Ala Glu Ala Glu Gly Cys Gln Arg Arg Arg Leu Leu Val Pro Val Asn 
                325                 330                 335     


Asp Ala Asp Ser Ala Asp Ile Ser Thr Leu Leu Asp Ala Ser Ala Thr 
            340                 345                 350         


Leu Glu Glu Gly His Ala Lys Glu Thr Ile Gln Asp Gln Leu Val Gly 
        355                 360                 365             


Ser Glu Lys Leu Phe Tyr Glu Glu Asp Glu Ala Gly Ser Ala Thr Ser 
    370                 375                 380                 


Cys Leu 
385     


<210>  9
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequences of TRAIL-R1/ TNFRSF10A

<400>  9

Met Ala Pro Pro Pro Ala Arg Val His Leu Gly Ala Phe Leu Ala Val 
1               5                   10                  15      


Thr Pro Asn Pro Gly Ser Ala Ala Ser Gly Thr Glu Ala Ala Ala Ala 
            20                  25                  30          


Thr Pro Ser Lys Val Trp Gly Ser Ser Ala Gly Arg Ile Glu Pro Arg 
        35                  40                  45              


Gly Gly Gly Arg Gly Ala Leu Pro Thr Ser Met Gly Gln His Gly Pro 
    50                  55                  60                  


Ser Ala Arg Ala Arg Ala Gly Arg Ala Pro Gly Pro Arg Pro Ala Arg 
65                  70                  75                  80  


Glu Ala Ser Pro Arg Leu Arg Val His Lys Thr Phe Lys Phe Val Val 
                85                  90                  95      


Val Gly Val Leu Leu Gln Val Val Pro Ser Ser Ala Ala Thr Ile Lys 
            100                 105                 110         


Leu His Asp Gln Ser Ile Gly Thr Gln Gln Trp Glu His Ser Pro Leu 
        115                 120                 125             


Gly Glu Leu Cys Pro Pro Gly Ser His Arg Ser Glu His Pro Gly Ala 
    130                 135                 140                 


Cys Asn Arg Cys Thr Glu Gly Val Gly Tyr Thr Asn Ala Ser Asn Asn 
145                 150                 155                 160 


Leu Phe Ala Cys Leu Pro Cys Thr Ala Cys Lys Ser Asp Glu Glu Glu 
                165                 170                 175     


Arg Ser Pro Cys Thr Thr Thr Arg Asn Thr Ala Cys Gln Cys Lys Pro 
            180                 185                 190         


Gly Thr Phe Arg Asn Asp Asn Ser Ala Glu Met Cys Arg Lys Cys Ser 
        195                 200                 205             


Arg Gly Cys Pro Arg Gly Met Val Lys Val Lys Asp Cys Thr Pro Trp 
    210                 215                 220                 


Ser Asp Ile Glu Cys Val His Lys Glu Ser Gly Asn Gly His Asn Ile 
225                 230                 235                 240 


Trp Val Ile Leu Val Val Thr Leu Val Val Pro Leu Leu Leu Val Ala 
                245                 250                 255     


Val Leu Ile Val Cys Cys Cys Ile Gly Ser Gly Cys Gly Gly Asp Pro 
            260                 265                 270         


Lys Cys Met Asp Arg Val Cys Phe Trp Arg Leu Gly Leu Leu Arg Gly 
        275                 280                 285             


Pro Gly Ala Glu Asp Asn Ala His Asn Glu Ile Leu Ser Asn Ala Asp 
    290                 295                 300                 


Ser Leu Ser Thr Phe Val Ser Glu Gln Gln Met Glu Ser Gln Glu Pro 
305                 310                 315                 320 


Ala Asp Leu Thr Gly Val Thr Val Gln Ser Pro Gly Glu Ala Gln Cys 
                325                 330                 335     


Leu Leu Gly Pro Ala Glu Ala Glu Gly Ser Gln Arg Arg Arg Leu Leu 
            340                 345                 350         


Val Pro Ala Asn Gly Ala Asp Pro Thr Glu Thr Leu Met Leu Phe Phe 
        355                 360                 365             


Asp Lys Phe Ala Asn Ile Val Pro Phe Asp Ser Trp Asp Gln Leu Met 
    370                 375                 380                 


Arg Gln Leu Asp Leu Thr Lys Asn Glu Ile Asp Val Val Arg Ala Gly 
385                 390                 395                 400 


Thr Ala Gly Pro Gly Asp Ala Leu Tyr Ala Met Leu Met Lys Trp Val 
                405                 410                 415     


Asn Lys Thr Gly Arg Asn Ala Ser Ile His Thr Leu Leu Asp Ala Leu 
            420                 425                 430         


Glu Arg Met Glu Glu Arg His Ala Arg Glu Lys Ile Gln Asp Leu Leu 
        435                 440                 445             


Val Asp Ser Gly Lys Phe Ile Tyr Leu Glu Asp Gly Thr Gly Ser Ala 
    450                 455                 460                 


Val Ser Leu Glu 
465             


<210>  10
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequences of TRAIL-R1/ TNFRSF10A

<400>  10

Met Ala Pro Pro Pro Ala Arg Val His Leu Gly Ala Phe Leu Ala Val 
1               5                   10                  15      


Thr Pro Asn Pro Gly Ser Ala Ala Ser Gly Thr Glu Ala Ala Ala Ala 
            20                  25                  30          


Thr Pro Ser Lys Val Trp Gly Ser Ser Ala Gly Arg Ile Glu Pro Arg 
        35                  40                  45              


Gly Gly Gly Arg Gly Ala Leu Pro Thr Ser Met Gly Gln His Gly Pro 
    50                  55                  60                  


Ser Ala Arg Ala Arg Ala Gly Arg Ala Pro Gly Pro Arg Pro Ala Arg 
65                  70                  75                  80  


Glu Ala Ser Pro Arg Leu Arg Val His Lys Thr Phe Lys Phe Val Val 
                85                  90                  95      


Val Gly Val Leu Leu Gln Val Val Pro Ser Ser Ala Ala Thr Ile Lys 
            100                 105                 110         


Leu His Asp Gln Ser Ile Gly Thr Gln Gln Trp Glu His Ser Pro Leu 
        115                 120                 125             


Gly Glu Leu Cys Pro Pro Gly Ser His Arg Ser Glu His Pro Gly Ala 
    130                 135                 140                 


Cys Asn Arg Cys Thr Glu Gly Val Gly Tyr Thr Asn Ala Ser Asn Asn 
145                 150                 155                 160 


Leu Phe Ala Cys Leu Pro Cys Thr Ala Cys Lys Ser Asp Glu Glu Glu 
                165                 170                 175     


Arg Ser Pro Cys Thr Thr Thr Arg Asn Thr Ala Cys Gln Cys Lys Pro 
            180                 185                 190         


Gly Thr Phe Arg Asn Asp Asn Ser Ala Glu Met Cys Arg Lys Cys Ser 
        195                 200                 205             


Arg Gly Cys Pro Arg Gly Met Val Lys Val Lys Asp Cys Thr Pro Trp 
    210                 215                 220                 


Ser Asp Ile Glu Cys Val His Lys Glu Ser Gly Asn Gly His Asn Ile 
225                 230                 235                 240 


Trp Val Ile Leu Val Val Thr Leu Val Val Pro Leu Leu Leu Val Ala 
                245                 250                 255     


Val Leu Ile Val Cys Cys Cys Ile Gly Ser Gly Cys Gly Gly Asp Pro 
            260                 265                 270         


Lys Cys Met Asp Arg Val Cys Phe Trp Arg Leu Gly Leu Leu Arg Gly 
        275                 280                 285             


Pro Gly Ala Glu Asp Asn Ala His Asn Glu Ile Leu Ser Asn Ala Asp 
    290                 295                 300                 


Ser Leu Ser Thr Phe Val Ser Glu Gln Gln Met Glu Ser Gln Glu Pro 
305                 310                 315                 320 


Ala Asp Leu Thr Gly Val Thr Val Gln Ser Pro Gly Glu Ala Gln Cys 
                325                 330                 335     


Leu Leu Gly Pro Ala Glu Ala Glu Gly Ser Gln Arg Arg Arg Leu Leu 
            340                 345                 350         


Val Pro Ala Asn Gly Ala Asp Pro Thr Glu Thr Leu Met Leu Phe Phe 
        355                 360                 365             


Asp Lys Phe Ala Asn Ile Val Pro Phe Asp Ser Trp Asp Gln Leu Met 
    370                 375                 380                 


Arg Gln Leu Asp Leu Thr Lys Asn Glu Ile Asp Val Val Arg Ala Gly 
385                 390                 395                 400 


Thr Ala Gly Pro Gly Asp Ala Leu Tyr Ala Met Leu Met Lys Trp Val 
                405                 410                 415     


Asn Lys Thr Gly Arg Asn Ala Ser Ile His Thr Leu Leu Asp Ala Leu 
            420                 425                 430         


Glu Arg Met Glu Glu Arg His Ala Arg Glu Lys Ile Gln Asp Leu Leu 
        435                 440                 445             


Val Asp Ser Gly Lys Phe Ile Tyr Leu Glu Asp Gly Thr Gly Ser Ala 
    450                 455                 460                 


Val Ser Leu Glu 
465             


<210>  11
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequences of TRAIL-R1/ TNFRSF10A

<400>  11

Met Ala Pro Pro Pro Ala Arg Val His Leu Ala Cys Lys Ser Asp Glu 
1               5                   10                  15      


Glu Glu Arg Ser Pro Cys Thr Thr Thr Arg Asn Thr Ala Cys Gln Cys 
            20                  25                  30          


Lys Pro Gly Thr Phe Arg Asn Asp Asn Ser Ala Glu Met Cys Arg Lys 
        35                  40                  45              


Cys Ser Arg Gly Cys Pro Arg Gly Met Val Lys Val Lys Asp Cys Thr 
    50                  55                  60                  


Pro Trp Ser Asp Ile Glu Cys Val His Lys Glu Ser Gly Asn Gly His 
65                  70                  75                  80  


Asn Ile Trp Val Ile Leu Val Val Thr Leu Val Val Pro Leu Leu Leu 
                85                  90                  95      


Val Ala Val Leu Ile Val Cys Cys Cys Ile Gly Ser Gly Cys Gly Gly 
            100                 105                 110         


Asp Pro Lys Cys Met Asp Arg Val Cys Phe Trp Arg Leu Gly Leu Leu 
        115                 120                 125             


Arg Gly Pro Gly Ala Glu Asp Asn Ala His Asn Glu Ile Leu Ser Asn 
    130                 135                 140                 


Ala Asp Ser Leu Ser Thr Phe Val Ser Glu Gln Gln Met Glu Ser Gln 
145                 150                 155                 160 


Glu Pro Ala Asp Leu Thr Gly Val Thr Val Gln Ser Pro Gly Glu Ala 
                165                 170                 175     


Gln Cys Leu Leu Gly Pro Ala Glu Ala Glu Gly Ser Gln Arg Arg Arg 
            180                 185                 190         


Leu Leu Val Pro Ala Asn Gly Ala Asp Pro Thr Glu Thr Leu Met Leu 
        195                 200                 205             


Phe Phe Asp Lys Phe Ala Asn Ile Val Pro Phe Asp Ser Trp Asp Gln 
    210                 215                 220                 


Leu Met Arg Gln Leu Asp Leu Thr Lys Asn Glu Ile Asp Val Val Arg 
225                 230                 235                 240 


Ala Gly Thr Ala Gly Pro Gly Asp Ala Leu Tyr Ala Met Leu Met Lys 
                245                 250                 255     


Trp Val Asn Lys Thr Gly Arg Asn Ala Ser Ile His Thr Leu Leu Asp 
            260                 265                 270         


Ala Leu Glu Arg Met Glu Glu Arg His Ala Arg Glu Lys Ile Gln Asp 
        275                 280                 285             


Leu Leu Val Asp Ser Gly Lys Phe Ile Tyr Leu Glu Asp Gly Thr Gly 
    290                 295                 300                 


Ser Ala Val Ser Leu Glu 
305                 310 


<210>  12
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequences of TRAIL-R2/ TNFRSF10B

<400>  12

Met Glu Gln Arg Gly Gln Asn Ala Pro Ala Ala Ser Gly Ala Arg Lys 
1               5                   10                  15      


Arg His Gly Pro Gly Pro Arg Glu Ala Arg Gly Ala Arg Pro Gly Pro 
            20                  25                  30          


Arg Val Pro Lys Thr Leu Val Leu Val Val Ala Ala Val Leu Leu Leu 
        35                  40                  45              


Val Ser Ala Glu Ser Ala Leu Ile Thr Gln Gln Asp Leu Ala Pro Gln 
    50                  55                  60                  


Gln Arg Ala Ala Pro Gln Gln Lys Arg Ser Ser Pro Ser Glu Gly Leu 
65                  70                  75                  80  


Cys Pro Pro Gly His His Ile Ser Glu Asp Gly Arg Asp Cys Ile Ser 
                85                  90                  95      


Cys Lys Tyr Gly Gln Asp Tyr Ser Thr His Trp Asn Asp Leu Leu Phe 
            100                 105                 110         


Cys Leu Arg Cys Thr Arg Cys Asp Ser Gly Glu Val Glu Leu Ser Pro 
        115                 120                 125             


Cys Thr Thr Thr Arg Asn Thr Val Cys Gln Cys Glu Glu Gly Thr Phe 
    130                 135                 140                 


Arg Glu Glu Asp Ser Pro Glu Met Cys Arg Lys Cys Arg Thr Gly Cys 
145                 150                 155                 160 


Pro Arg Gly Met Val Lys Val Gly Asp Cys Thr Pro Trp Ser Asp Ile 
                165                 170                 175     


Glu Cys Val His Lys Glu Ser Gly Thr Lys His Ser Gly Glu Val Pro 
            180                 185                 190         


Ala Val Glu Glu Thr Val Thr Ser Ser Pro Gly Thr Pro Ala Ser Pro 
        195                 200                 205             


Cys Ser Leu Ser Gly Ile Ile Ile Gly Val Thr Val Ala Ala Val Val 
    210                 215                 220                 


Leu Ile Val Ala Val Phe Val Cys Lys Ser Leu Leu Trp Lys Lys Val 
225                 230                 235                 240 


Leu Pro Tyr Leu Lys Gly Ile Cys Ser Gly Gly Gly Gly Asp Pro Glu 
                245                 250                 255     


Arg Val Asp Arg Ser Ser Gln Arg Pro Gly Ala Glu Asp Asn Val Leu 
            260                 265                 270         


Asn Glu Ile Val Ser Ile Leu Gln Pro Thr Gln Val Pro Glu Gln Glu 
        275                 280                 285             


Met Glu Val Gln Glu Pro Ala Glu Pro Thr Gly Val Asn Met Leu Ser 
    290                 295                 300                 


Pro Gly Glu Ser Glu His Leu Leu Glu Pro Ala Glu Ala Glu Arg Ser 
305                 310                 315                 320 


Gln Arg Arg Arg Leu Leu Val Pro Ala Asn Glu Gly Asp Pro Thr Glu 
                325                 330                 335     


Thr Leu Arg Gln Cys Phe Asp Asp Phe Ala Asp Leu Val Pro Phe Asp 
            340                 345                 350         


Ser Trp Glu Pro Leu Met Arg Lys Leu Gly Leu Met Asp Asn Glu Ile 
        355                 360                 365             


Lys Val Ala Lys Ala Glu Ala Ala Gly His Arg Asp Thr Leu Tyr Thr 
    370                 375                 380                 


Met Leu Ile Lys Trp Val Asn Lys Thr Gly Arg Asp Ala Ser Val His 
385                 390                 395                 400 


Thr Leu Leu Asp Ala Leu Glu Thr Leu Gly Glu Arg Leu Ala Lys Gln 
                405                 410                 415     


Lys Ile Glu Asp His Leu Leu Ser Ser Gly Lys Phe Met Tyr Leu Glu 
            420                 425                 430         


Gly Asn Ala Asp Ser Ala Met Ser 
        435                 440 


<210>  13
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequences of TRAIL-R2/ TNFRSF10B

<400>  13

Met Glu Gln Arg Gly Gln Asn Ala Pro Ala Ala Ser Gly Ala Arg Lys 
1               5                   10                  15      


Arg His Gly Pro Gly Pro Arg Glu Ala Arg Gly Ala Arg Pro Gly Pro 
            20                  25                  30          


Arg Val Pro Lys Thr Leu Val Leu Val Val Ala Ala Val Leu Leu Leu 
        35                  40                  45              


Val Ser Ala Glu Ser Ala Leu Ile Thr Gln Gln Asp Leu Ala Pro Gln 
    50                  55                  60                  


Gln Arg Ala Ala Pro Gln Gln Lys Arg Ser Ser Pro Ser Glu Gly Leu 
65                  70                  75                  80  


Cys Pro Pro Gly His His Ile Ser Glu Asp Gly Arg Asp Cys Ile Ser 
                85                  90                  95      


Cys Lys Tyr Gly Gln Asp Tyr Ser Thr His Trp Asn Asp Leu Leu Phe 
            100                 105                 110         


Cys Leu Arg Cys Thr Arg Cys Asp Ser Gly Glu Val Glu Leu Ser Pro 
        115                 120                 125             


Cys Thr Thr Thr Arg Asn Thr Val Cys Gln Cys Glu Glu Gly Thr Phe 
    130                 135                 140                 


Arg Glu Glu Asp Ser Pro Glu Met Cys Arg Lys Cys Arg Thr Gly Cys 
145                 150                 155                 160 


Pro Arg Gly Met Val Lys Val Gly Asp Cys Thr Pro Trp Ser Asp Ile 
                165                 170                 175     


Glu Cys Val His Lys Glu Ser Gly Thr Lys His Ser Gly Glu Val Pro 
            180                 185                 190         


Ala Val Glu Glu Thr Val Thr Ser Ser Pro Gly Thr Pro Ala Ser Pro 
        195                 200                 205             


Cys Ser Leu Ser Gly Ile Ile Ile Gly Val Thr Val Ala Ala Val Val 
    210                 215                 220                 


Leu Ile Val Ala Val Phe Val Cys Lys Ser Leu Leu Trp Lys Lys Val 
225                 230                 235                 240 


Leu Pro Tyr Leu Lys Gly Ile Cys Ser Gly Gly Gly Gly Asp Pro Glu 
                245                 250                 255     


Arg Val Asp Arg Ser Ser Gln Arg Pro Gly Ala Glu Asp Asn Val Leu 
            260                 265                 270         


Asn Glu Ile Val Ser Ile Leu Gln Pro Thr Gln Val Pro Glu Gln Glu 
        275                 280                 285             


Met Glu Val Gln Glu Pro Ala Glu Pro Thr Gly Val Asn Met Leu Ser 
    290                 295                 300                 


Pro Gly Glu Ser Glu His Leu Leu Glu Pro Ala Glu Ala Glu Arg Ser 
305                 310                 315                 320 


Gln Arg Arg Arg Leu Leu Val Pro Ala Asn Glu Gly Asp Pro Thr Glu 
                325                 330                 335     


Thr Leu Arg Gln Cys Phe Asp Asp Phe Ala Asp Leu Val Pro Phe Asp 
            340                 345                 350         


Ser Trp Glu Pro Leu Met Arg Lys Leu Gly Leu Met Asp Asn Glu Ile 
        355                 360                 365             


Lys Val Ala Lys Ala Glu Ala Ala Gly His Arg Asp Thr Leu Tyr Thr 
    370                 375                 380                 


Met Leu Ile Lys Trp Val Asn Lys Thr Gly Arg Asp Ala Ser Val His 
385                 390                 395                 400 


Thr Leu Leu Asp Ala Leu Glu Thr Leu Gly Glu Arg Leu Ala Lys Gln 
                405                 410                 415     


Lys Ile Glu Asp His Leu Leu Ser Ser Gly Lys Phe Met Tyr Leu Glu 
            420                 425                 430         


Gly Asn Ala Asp Ser Ala Met Ser 
        435                 440 


<210>  14
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequences of TRAIL-R2/ TNFRSF10B

<400>  14

Met Glu Gln Arg Gly Gln Asn Ala Pro Ala Ala Ser Gly Ala Arg Lys 
1               5                   10                  15      


Arg His Gly Pro Gly Pro Arg Glu Ala Arg Gly Ala Arg Pro Gly Pro 
            20                  25                  30          


Arg Val Pro Lys Thr Leu Val Leu Val Val Ala Ala Val Leu Leu Leu 
        35                  40                  45              


Val Ser Ala Glu Ser Ala Leu Ile Thr Gln Gln Asp Leu Ala Pro Gln 
    50                  55                  60                  


Gln Arg Ala Ala Pro Gln Gln Lys Arg Ser Ser Pro Ser Glu Gly Leu 
65                  70                  75                  80  


Cys Pro Pro Gly His His Ile Ser Glu Asp Gly Arg Asp Cys Ile Ser 
                85                  90                  95      


Cys Lys Tyr Gly Gln Asp Tyr Ser Thr His Trp Asn Asp Leu Leu Phe 
            100                 105                 110         


Cys Leu Arg Cys Thr Arg Cys Asp Ser Gly Glu Val Glu Leu Ser Pro 
        115                 120                 125             


Cys Thr Thr Thr Arg Asn Thr Val Cys Gln Cys Glu Glu Gly Thr Phe 
    130                 135                 140                 


Arg Glu Glu Asp Ser Pro Glu Met Cys Arg Lys Cys Arg Thr Gly Cys 
145                 150                 155                 160 


Pro Arg Gly Met Val Lys Val Gly Asp Cys Thr Pro Trp Ser Asp Ile 
                165                 170                 175     


Glu Cys Val His Lys Glu Ser Gly Ile Ile Ile Gly Val Thr Val Ala 
            180                 185                 190         


Ala Val Val Leu Ile Val Ala Val Phe Val Cys Lys Ser Leu Leu Trp 
        195                 200                 205             


Lys Lys Val Leu Pro Tyr Leu Lys Gly Ile Cys Ser Gly Gly Gly Gly 
    210                 215                 220                 


Asp Pro Glu Arg Val Asp Arg Ser Ser Gln Arg Pro Gly Ala Glu Asp 
225                 230                 235                 240 


Asn Val Leu Asn Glu Ile Val Ser Ile Leu Gln Pro Thr Gln Val Pro 
                245                 250                 255     


Glu Gln Glu Met Glu Val Gln Glu Pro Ala Glu Pro Thr Gly Val Asn 
            260                 265                 270         


Met Leu Ser Pro Gly Glu Ser Glu His Leu Leu Glu Pro Ala Glu Ala 
        275                 280                 285             


Glu Arg Ser Gln Arg Arg Arg Leu Leu Val Pro Ala Asn Glu Gly Asp 
    290                 295                 300                 


Pro Thr Glu Thr Leu Arg Gln Cys Phe Asp Asp Phe Ala Asp Leu Val 
305                 310                 315                 320 


Pro Phe Asp Ser Trp Glu Pro Leu Met Arg Lys Leu Gly Leu Met Asp 
                325                 330                 335     


Asn Glu Ile Lys Val Ala Lys Ala Glu Ala Ala Gly His Arg Asp Thr 
            340                 345                 350         


Leu Tyr Thr Met Leu Ile Lys Trp Val Asn Lys Thr Gly Arg Asp Ala 
        355                 360                 365             


Ser Val His Thr Leu Leu Asp Ala Leu Glu Thr Leu Gly Glu Arg Leu 
    370                 375                 380                 


Ala Lys Gln Lys Ile Glu Asp His Leu Leu Ser Ser Gly Lys Phe Met 
385                 390                 395                 400 


Tyr Leu Glu Gly Asn Ala Asp Ser Ala Met Ser 
                405                 410     


<210>  15
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of NGAL

<400>  15

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
            20                  25                  30          


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln 
        35                  40                  45              


Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu 
    50                  55                  60                  


Asp Lys Asp Pro Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu 
65                  70                  75                  80  


Asp Lys Ser Tyr Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys 
                85                  90                  95      


Asp Tyr Trp Ile Arg Thr Phe Val Pro Gly Cys Gln Pro Gly Glu Phe 
            100                 105                 110         


Thr Leu Gly Asn Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val 
        115                 120                 125             


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
    130                 135                 140                 


Lys Val Ser Gln Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg 
145                 150                 155                 160 


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
                165                 170                 175     


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
            180                 185                 190         


Asp Gln Cys Ile Asp Gly 
        195             


<210>  16
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequences of MMP8

<400>  16

Met Gln Gln Ile Pro Gln Glu Lys Ser Ile Asn Asp Tyr Leu Glu Lys 
1               5                   10                  15      


Phe Tyr Gln Leu Pro Ser Asn Gln Tyr Gln Ser Thr Arg Lys Asn Gly 
            20                  25                  30          


Thr Asn Val Ile Val Glu Lys Leu Lys Glu Met Gln Arg Phe Phe Gly 
        35                  40                  45              


Leu Asn Val Thr Gly Lys Pro Asn Glu Glu Thr Leu Asp Met Met Lys 
    50                  55                  60                  


Lys Pro Arg Cys Gly Val Pro Asp Ser Gly Gly Phe Met Leu Thr Pro 
65                  70                  75                  80  


Gly Asn Pro Lys Trp Glu Arg Thr Asn Leu Thr Tyr Arg Ile Arg Asn 
                85                  90                  95      


Tyr Thr Pro Gln Leu Ser Glu Ala Glu Val Glu Arg Ala Ile Lys Asp 
            100                 105                 110         


Ala Phe Glu Leu Trp Ser Val Ala Ser Pro Leu Ile Phe Thr Arg Ile 
        115                 120                 125             


Ser Gln Gly Glu Ala Asp Ile Asn Ile Ala Phe Tyr Gln Arg Asp His 
    130                 135                 140                 


Gly Asp Asn Ser Pro Phe Asp Gly Pro Asn Gly Ile Leu Ala His Ala 
145                 150                 155                 160 


Phe Gln Pro Gly Gln Gly Ile Gly Gly Asp Ala His Phe Asp Ala Glu 
                165                 170                 175     


Glu Thr Trp Thr Asn Thr Ser Ala Asn Tyr Asn Leu Phe Leu Val Ala 
            180                 185                 190         


Ala His Glu Phe Gly His Ser Leu Gly Leu Ala His Ser Ser Asp Pro 
        195                 200                 205             


Gly Ala Leu Met Tyr Pro Asn Tyr Ala Phe Arg Glu Thr Ser Asn Tyr 
    210                 215                 220                 


Ser Leu Pro Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile Tyr Gly Leu 
225                 230                 235                 240 


Ser Ser Asn Pro Ile Gln Pro Thr Gly Pro Ser Thr Pro Lys Pro Cys 
                245                 250                 255     


Asp Pro Ser Leu Thr Phe Asp Ala Ile Thr Thr Leu Arg Gly Glu Ile 
            260                 265                 270         


Leu Phe Phe Lys Asp Arg Tyr Phe Trp Arg Arg His Pro Gln Leu Gln 
        275                 280                 285             


Arg Val Glu Met Asn Phe Ile Ser Leu Phe Trp Pro Ser Leu Pro Thr 
    290                 295                 300                 


Gly Ile Gln Ala Ala Tyr Glu Asp Phe Asp Arg Asp Leu Ile Phe Leu 
305                 310                 315                 320 


Phe Lys Gly Asn Gln Tyr Trp Ala Leu Ser Gly Tyr Asp Ile Leu Gln 
                325                 330                 335     


Gly Tyr Pro Lys Asp Ile Ser Asn Tyr Gly Phe Pro Ser Ser Val Gln 
            340                 345                 350         


Ala Ile Asp Ala Ala Val Phe Tyr Arg Ser Lys Thr Tyr Phe Phe Val 
        355                 360                 365             


Asn Asp Gln Phe Trp Arg Tyr Asp Asn Gln Arg Gln Phe Met Glu Pro 
    370                 375                 380                 


Gly Tyr Pro Lys Ser Ile Ser Gly Ala Phe Pro Gly Ile Glu Ser Lys 
385                 390                 395                 400 


Val Asp Ala Val Phe Gln Gln Glu His Phe Phe His Val Phe Ser Gly 
                405                 410                 415     


Pro Arg Tyr Tyr Ala Phe Asp Leu Ile Ala Gln Arg Val Thr Arg Val 
            420                 425                 430         


Ala Arg Gly Asn Lys Trp Leu Asn Cys Arg Tyr Gly 
        435                 440                 


<210>  17
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequences of MMP8

<400>  17

Met Gln Gln Ile Pro Gln Glu Lys Ser Ile Asn Asp Tyr Leu Glu Lys 
1               5                   10                  15      


Phe Tyr Gln Leu Pro Ser Asn Gln Tyr Gln Ser Thr Arg Lys Asn Gly 
            20                  25                  30          


Thr Asn Val Ile Val Glu Lys Leu Lys Glu Met Gln Arg Phe Phe Gly 
        35                  40                  45              


Leu Asn Val Thr Gly Lys Pro Asn Glu Glu Thr Leu Asp Met Met Lys 
    50                  55                  60                  


Lys Pro Arg Cys Gly Val Pro Asp Ser Gly Gly Phe Met Leu Thr Pro 
65                  70                  75                  80  


Gly Asn Pro Lys Trp Glu Arg Thr Asn Leu Thr Tyr Arg Ile Arg Asn 
                85                  90                  95      


Tyr Thr Pro Gln Leu Ser Glu Ala Glu Val Glu Arg Ala Ile Lys Asp 
            100                 105                 110         


Ala Phe Glu Leu Trp Ser Val Ala Ser Pro Leu Ile Phe Thr Arg Ile 
        115                 120                 125             


Ser Gln Gly Glu Ala Asp Ile Asn Ile Ala Phe Tyr Gln Arg Asp His 
    130                 135                 140                 


Gly Asp Asn Ser Pro Phe Asp Gly Pro Asn Gly Ile Leu Ala His Ala 
145                 150                 155                 160 


Phe Gln Pro Gly Gln Gly Ile Gly Gly Asp Ala His Phe Asp Ala Glu 
                165                 170                 175     


Glu Thr Trp Thr Asn Thr Ser Ala Asn Tyr Asn Leu Phe Leu Val Ala 
            180                 185                 190         


Ala His Glu Phe Gly His Ser Leu Gly Leu Ala His Ser Ser Asp Pro 
        195                 200                 205             


Gly Ala Leu Met Tyr Pro Asn Tyr Ala Phe Arg Glu Thr Ser Asn Tyr 
    210                 215                 220                 


Ser Leu Pro Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile Tyr Gly Leu 
225                 230                 235                 240 


Ser Ser Asn Pro Ile Gln Pro Thr Gly Pro Ser Thr Pro Lys Pro Cys 
                245                 250                 255     


Asp Pro Ser Leu Thr Phe Asp Ala Ile Thr Thr Leu Arg Gly Glu Ile 
            260                 265                 270         


Leu Phe Phe Lys Asp Arg Tyr Phe Trp Arg Arg His Pro Gln Leu Gln 
        275                 280                 285             


Arg Val Glu Met Asn Phe Ile Ser Leu Phe Trp Pro Ser Leu Pro Thr 
    290                 295                 300                 


Gly Ile Gln Ala Ala Tyr Glu Asp Phe Asp Arg Asp Leu Ile Phe Leu 
305                 310                 315                 320 


Phe Lys Gly Asn Gln Tyr Trp Ala Leu Ser Gly Tyr Asp Ile Leu Gln 
                325                 330                 335     


Gly Tyr Pro Lys Asp Ile Ser Asn Tyr Gly Phe Pro Ser Ser Val Gln 
            340                 345                 350         


Ala Ile Asp Ala Ala Val Phe Tyr Arg Ser Lys Thr Tyr Phe Phe Val 
        355                 360                 365             


Asn Asp Gln Phe Trp Arg Tyr Asp Asn Gln Arg Gln Phe Met Glu Pro 
    370                 375                 380                 


Gly Tyr Pro Lys Ser Ile Ser Gly Ala Phe Pro Gly Ile Glu Ser Lys 
385                 390                 395                 400 


Val Asp Ala Val Phe Gln Gln Glu His Phe Phe His Val Phe Ser Gly 
                405                 410                 415     


Pro Arg Tyr Tyr Ala Phe Asp Leu Ile Ala Gln Arg Val Thr Arg Val 
            420                 425                 430         


Ala Arg Gly Asn Lys Trp Leu Asn Cys Arg Tyr Gly 
        435                 440                 


<210>  18
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequences of MMP8

<400>  18

Met Phe Ser Leu Lys Thr Leu Pro Phe Leu Leu Leu Leu His Val Gln 
1               5                   10                  15      


Ile Ser Lys Ala Phe Pro Val Ser Ser Lys Glu Lys Asn Thr Lys Thr 
            20                  25                  30          


Val Gln Asp Tyr Leu Glu Lys Phe Tyr Gln Leu Pro Ser Asn Gln Tyr 
        35                  40                  45              


Gln Ser Thr Arg Lys Asn Gly Thr Asn Val Ile Val Glu Lys Leu Lys 
    50                  55                  60                  


Glu Met Gln Arg Phe Phe Gly Leu Asn Val Thr Gly Lys Pro Asn Glu 
65                  70                  75                  80  


Glu Thr Leu Asp Met Met Lys Lys Pro Arg Cys Gly Val Pro Asp Ser 
                85                  90                  95      


Gly Gly Phe Met Leu Thr Pro Gly Asn Pro Lys Trp Glu Arg Thr Asn 
            100                 105                 110         


Leu Thr Tyr Arg Ile Arg Asn Tyr Thr Pro Gln Leu Ser Glu Ala Glu 
        115                 120                 125             


Val Glu Arg Ala Ile Lys Asp Ala Phe Glu Leu Trp Ser Val Ala Ser 
    130                 135                 140                 


Pro Leu Ile Phe Thr Arg Ile Ser Gln Gly Glu Ala Asp Ile Asn Ile 
145                 150                 155                 160 


Ala Phe Tyr Gln Arg Asp His Gly Asp Asn Ser Pro Phe Asp Gly Pro 
                165                 170                 175     


Asn Gly Ile Leu Ala His Ala Phe Gln Pro Gly Gln Gly Ile Gly Gly 
            180                 185                 190         


Asp Ala His Phe Asp Ala Glu Glu Thr Trp Thr Asn Thr Ser Ala Asn 
        195                 200                 205             


Tyr Asn Leu Phe Leu Val Ala Ala His Glu Phe Gly His Ser Leu Gly 
    210                 215                 220                 


Leu Ala His Ser Ser Asp Pro Gly Ala Leu Met Tyr Pro Asn Tyr Ala 
225                 230                 235                 240 


Phe Arg Glu Thr Ser Asn Tyr Ser Leu Pro Gln Asp Asp Ile Asp Gly 
                245                 250                 255     


Ile Gln Ala Ile Tyr Gly Leu Ser Ser Asn Pro Ile Gln Pro Thr Gly 
            260                 265                 270         


Pro Ser Thr Pro Lys Pro Cys Asp Pro Ser Leu Thr Phe Asp Ala Ile 
        275                 280                 285             


Thr Thr Leu Arg Gly Glu Ile Leu Phe Phe Lys Asp Arg Tyr Phe Trp 
    290                 295                 300                 


Arg Arg His Pro Gln Leu Gln Arg Val Glu Met Asn Phe Ile Ser Leu 
305                 310                 315                 320 


Phe Trp Pro Ser Leu Pro Thr Gly Ile Gln Ala Ala Tyr Glu Asp Phe 
                325                 330                 335     


Asp Arg Asp Leu Ile Phe Leu Phe Lys Gly Asn Gln Tyr Trp Ala Leu 
            340                 345                 350         


Ser Gly Tyr Asp Ile Leu Gln Gly Tyr Pro Lys Asp Ile Ser Asn Tyr 
        355                 360                 365             


Gly Phe Pro Ser Ser Val Gln Ala Ile Asp Ala Ala Val Phe Tyr Arg 
    370                 375                 380                 


Ser Lys Thr Tyr Phe Phe Val Asn Asp Gln Phe Trp Arg Tyr Asp Asn 
385                 390                 395                 400 


Gln Arg Gln Phe Met Glu Pro Gly Tyr Pro Lys Ser Ile Ser Gly Ala 
                405                 410                 415     


Phe Pro Gly Ile Glu Ser Lys Val Asp Ala Val Phe Gln Gln Glu His 
            420                 425                 430         


Phe Phe His Val Phe Ser Gly Pro Arg Tyr Tyr Ala Phe Asp Leu Ile 
        435                 440                 445             


Ala Gln Arg Val Thr Arg Val Ala Arg Gly Asn Lys Trp Leu Asn Cys 
    450                 455                 460                 


Arg Tyr Gly 
465         


