                         SEQUENCE LISTING

<110>  INBIOMOTION S.L.
       GOMIS, ROGER
       TERCERO, JUAN CARLOS
 
<120>  BINDING MEMBERS FOR HUMAN C-MAF

<130>  3190.012PC01/TJS/E-H

<150>  US 62/090,599
<151>  2014-12-11 

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  6878
<212>  DNA
<213>  Homo sapiens

<400>  1
agaggcttta aaatcttttt tcatcttcta gctgtagctc gggctgcttg tcggcttggc       60

ctccccctcc cccctttgct ctctgcctcg tctttcccca ggacttcgct attttgcttt      120

tttaaaaaaa ggcaagaaag aactaaactc ccccctccct ctcctccagt cgggctgcac      180

ctctgccttg cactttgcac agaggtagag agcgcgcgag ggagagagag gaaagaaaaa      240

aaataataaa gagagccaag cagaagagga ggcgagaagc atgaagtgtt aactcccccg      300

tgccaaggcc cgcgccgccc ggacagacgc ccgccgcgcc tccagccccg agcggacgcc      360

gcgcgcgccc tgcctgcagc ccgggccggc gaggcgagcc cttccttatg caaagcgcgc      420

agcggagcgg cgagcggggg acgccgcgca ccgggccggg ctcctccagc ttcgccgccg      480

cagccaccac cgccgccacc gcagctcgcg gaggatcttc ccgagcctga agccgccggc      540

tcggcgcgca aggaggcgag cgagcaagga ggggccgggg cgagcgaggg agcacattgg      600

cgtgagcagg ggggagggag ggcgggcgcg gggggcgcgg gcagggcggg ggggtgtgtg      660

tgtgagcgcg ctcggaggtt tcgggccagc caccgccgcg caagctagaa gcgccccagc      720

ccggcaagct ggctcacccg ctggccaccc agcacagccc gctggcccct ctcctgcagc      780

ccatctggcg gagcggcggc ggcggcggcg gcggcggcag gagaatggca tcagaactgg      840

caatgagcaa ctccgacctg cccaccagtc ccctggccat ggaatatgtt aatgacttcg      900

atctgatgaa gtttgaagtg aaaaaggaac cggtggagac cgaccgcatc atcagccagt      960

gcggccgtct catcgccggg ggctcgctgt cctccacccc catgagcacg ccgtgcagct     1020

cggtgccccc ttcccccagc ttctcggcgc ccagcccggg ctcgggcagc gagcagaagg     1080

cgcacctgga agactactac tggatgaccg gctacccgca gcagctgaac cccgaggcgc     1140

tgggcttcag ccccgaggac gcggtcgagg cgctcatcag caacagccac cagctccagg     1200

gcggcttcga tggctacgcg cgcggggcgc agcagctggc cgcggcggcc ggggccggtg     1260

ccggcgcctc cttgggcggc agcggcgagg agatgggccc cgccgccgcc gtggtgtccg     1320

ccgtgatcgc cgcggccgcc gcgcagagcg gcgcgggccc gcactaccac caccaccacc     1380

accacgccgc cggccaccac caccacccga cggccggcgc gcccggcgcc gcgggcagcg     1440

cggccgcctc ggccggtggc gctgggggcg cgggcggcgg tggcccggcc agcgctgggg     1500

gcggcggcgg cggcggcggc ggcggaggcg gcgggggcgc ggcgggggcg gggggcgccc     1560

tgcacccgca ccacgccgcc ggcggcctgc acttcgacga ccgcttctcc gacgagcagc     1620

tggtgaccat gtctgtgcgc gagctgaacc ggcagctgcg cggggtcagc aaggaggagg     1680

tgatccggct gaagcagaag aggcggaccc tgaaaaaccg cggctatgcc cagtcctgcc     1740

gcttcaagag ggtgcagcag agacacgtcc tggagtcgga gaagaaccag ctgctgcagc     1800

aagtcgacca cctcaagcag gagatctcca ggctggtgcg cgagagggac gcgtacaagg     1860

agaaatacga gaagttggtg agcagcggct tccgagaaaa cggctcgagc agcgacaacc     1920

cgtcctctcc cgagtttttc atgtgagtct gacacgcgat tccagctagc caccctgata     1980

agtgctccgc gggggtccgg ctcgggtgtg ggcttgctag ttctagagcc atgctcgcca     2040

ccacctcacc acccccaccc ccaccgagtt tggccccctt ggccccctac acacacacaa     2100

acccgcacgc acacaccaca cacacacaca cacacacaca cacaccccac accctgctcg     2160

agtttgtggt ggtggtggct gttttaaact ggggagggaa tgggtgtctg gctcatggat     2220

tgccaatctg aaattctcca taacttgcta gcttgttttt tttttttttt tacacccccc     2280

cgccccaccc ccggacttgc acaatgttca atgatctcag cagagttctt catgtgaaac     2340

gttgatcacc tttgaagcct gcatcattca catatttttt cttcttcttc cccttcagtt     2400

catgaactgg tgttcatttt ctgtgtgtgt gtgtgtttta ttttgtttgg attttttttt     2460

ttaattttac ttttagagct tgctgtgttg cccacctttt ttccaacctc caccctcact     2520

ccttctcaac ccatctcttc cgagatgaaa gaaaaaaaaa agcaaagttt ttttttcttc     2580

tcctgagttc ttcatgtgag attgagcttg caaaggaaaa aaaaatgtga aatgttatag     2640

acttgcagcg tgccgagttc catcgggttt tttttttagc attgttatgc taaaatagag     2700

aaaaaaatcc tcatgaacct tccacaatca agcctgcatc aaccttctgg gtgtgacttg     2760

tgagttttgg ccttgtgatg ccaaatctga gagtttagtc tgccattaaa aaaactcatt     2820

ctcatctcat gcattattat gcttgctact ttgtcttagc aacaatgaac tataactgtt     2880

tcaaagactt tatggaaaag agacattata ttaataaaaa aaaaaagcct gcatgctgga     2940

catgtatggt ataattattt tttccttttt ttttcctttt ggcttggaaa tggacgttcg     3000

aagacttata gcatggcatt catacttttg ttttattgcc tcatgacttt tttgagttta     3060

gaacaaaaca gtgcaaccgt agagccttct tcccatgaaa ttttgcatct gctccaaaac     3120

tgctttgagt tactcagaac ttcaacctcc caatgcactg aaggcattcc ttgtcaaaga     3180

taccagaatg ggttacacat ttaacctggc aaacattgaa gaactcttaa tgttttcttt     3240

ttaataagaa tgacgcccca ctttggggac taaaattgtg ctattgccga gaagcagtct     3300

aaaatttatt ttttaaaaag agaaactgcc ccattatttt tggtttgttt tatttttatt     3360

ttatattttt tggcttttgg tcattgtcaa atgtggaatg ctctgggttt ctagtatata     3420

atttaattct agtttttata atctgttagc ccagttaaaa tgtatgctac agataaagga     3480

atgttataga taaatttgaa agagttaggt ctgtttagct gtagattttt taaacgattg     3540

atgcactaaa ttgtttacta ttgtgatgtt aaggggggta gagtttgcaa ggggactgtt     3600

taaaaaaagt agcttataca gcatgtgctt gcaacttaaa tataagttgg gtatgtgtag     3660

tctttgctat accactgact gtattgaaaa ccaaagtatt aagaggggaa acgcccctgt     3720

ttatatctgt aggggtattt tacattcaaa aatgtatgtt tttttttctt ttcaaaatta     3780

aagtatttgg gactgaattg cactaagata taacctgcaa gcatataata caaaaaaaaa     3840

ttgcaaaact gtttagaacg ctaataaaat ttatgcagtt ataaaaatgg cattactgca     3900

cagttttaag atgatgcaga tttttttaca gttgtattgt ggtgcagaac tggattttct     3960

gtaacttaaa aaaaaatcca cagttttaaa ggcaataatc agtaaatgtt attttcaggg     4020

actgacatcc tgtctttaaa aagaaatgaa aagtaaatct taccacaata aatataaaaa     4080

aatcttgtca gttacttttc ttttacatat tttgctgtgc aaaattgttt tatatcttga     4140

gttactaact aaccacgcgt gttgttccta tgtgcttttc tttcattttc aattctggtt     4200

atatcaagaa aagaataatc tacaataata aacggcattt ttttttgatt ctgtactcag     4260

tttcttagtg tacagtttaa ctgggcccaa caacctcgtt aaaagtgtaa aatgcatcct     4320

tttctccagt ggaaggattc ctggaggaat agggagacag taattcaggg tgaaattata     4380

ggctgttttt tgaagtgagg aggctggccc catatactga ttagcaatat ttaatataga     4440

tgtaaattat gacctcattt ttttctcccc aaagttttca gttttcaaat gagttgagcc     4500

ataattgccc ttggtaggaa aaacaaaaca aaacagtgga actaggcttc ctgagcatgg     4560

ccctacactt ctgatcagga gcaaagccat ccatagacag aggagccgga caaatatggc     4620

gcatcagagg tggcttgcgc acatatgcat tgaacggtaa agagaaacag cgcttgcctt     4680

ttcactaaag ttgactattt ttccttcttc tcttacacac cgagattttc ttgttagcaa     4740

ggcctgacaa gatttaacat aaacatgaca aatcatagtt gtttgttttg ttttgctttt     4800

ctctttaaca ctgaagatca tttgtcttaa ataggaaaaa gaaaatccac tccttacttc     4860

catatttcca agtacatatc tggtttaaac tatgttatca aatcatattt caccgtgaat     4920

attcagtgga gaacttctct acctggatga gctagtaatg atttcagatc atgctatccc     4980

cagaaataaa agcaaaaaat aatacctgtg tggaatatag gctgtgcttt gatttactgg     5040

tatttacccc aaaataggct gtgtatgggg gctgacttaa agatcccttg gaaagactca     5100

aaactacctt cactagtagg actcctaagc gctgacctat ttttaaatga cacaaattca     5160

tgaaactaat gttacaaatt catgcagttt gcactcttag tcatcttccc ctagcacacc     5220

aatagaatgt tagacaaagc cagcactgtt ttgaaaatac agccaaacac gatgactttt     5280

gttttgtttt ctgccgttct taaaagaaaa aaagataata ttgcaactct gactgaaaga     5340

cttattttta agaaaacagg ttgtgtttgg tgctgctaag ttctggccag tttatcatct     5400

ggccttcctg cctatttttt acaaaacacg aagacagtgt gtaacctcga cattttgacc     5460

ttcctttatg tgctagttta gacaggctcc tgaatccaca cttaattttg cttaacaaaa     5520

gtcttaatag taaacctccc ctcatgagct tgaagtcaag tgttcttgac ttcagatatt     5580

tctttccttt tttttttttt ttcctcatca caactaagag atacacaaac tctgaagaag     5640

cagaaatgga gagaatgctt ttaacaaaaa agcatctgat gaaagatttt aggcaaacat     5700

tctcaaaata agagtgatat tctggatgta gttattgcag ttatctcatg acaaatgagg     5760

cctggattgg aaggaaaata tagttgtgta gaattaagca ttttgatagg aatctacaag     5820

gtagttgaat ataataagca ggtttgggcc cccaaacttt agaaaatcaa atgcaaaggt     5880

gctggcaaaa atgaggtttg agtggctggc tgtaagagaa ggttaactcc tagtaaaagg     5940

catttttaga aataacaatt actgaaaact ttgaagtata gtgggagtag caaacaaata     6000

catgtttttt ttttcttaca aagaactcct aaatcctgag taagtgccat tcattacaat     6060

aagtctctaa atttaaaaaa aaaaaaatca tatgaggaaa tctagctttc ccctttacgc     6120

tgcgtttgat ctttgtctaa atagtgttaa aattcctttc attccaatta cagaactgag     6180

cccactcgca agttggagcc atcagtggga tacgccacat tttggaagcc ccagcatcgt     6240

gtacttacca gtgtgttcac aaaatgaaat ttgtgtgaga gctgtacatt aaaaaaaatc     6300

atcattatta ttattatttg cagtcatgga gaaccaccta cccctgactt ctgtttagtc     6360

tcctttttaa ataaaaatta ctgtgttaga gaagaaggct attaaatgta gtagttaact     6420

atgcctcttg tctgggggtt tcatagagac cggtaggaaa gcgcactcct gcttttcgat     6480

ttatggtgtg tgcaagtaaa caggtgcatt gctttcaacc tgccatacta gttttaaaaa     6540

ttcactgaaa ttacaaagat acatatatat gcatatatat aatggaaagt ttcccggaat     6600

gcaacaatta gcattttaaa atcatatata ggcatgcaca ttctaaatag tactttttca     6660

tgcttcattg tttctctggc agataatttt actaagaaga aaaatagata ttcgactccc     6720

cttccctaaa caaatccacg ggcagaggct ccagcggagc cgagccccct ggttttctcg     6780

taggccctag acggtgttgc atttatcagt gatgtcaaac gtgctcattt gtcagacata     6840

gctgtaaatg aaaacaatgt gtggcaaaat acaaagtt                             6878


<210>  2
<211>  2656
<212>  DNA
<213>  Homo sapiens

<400>  2
gaggctttaa aatctttttt catcttctag ctgtagctcg ggctgcttgt cggcttggcc       60

tccccctccc ccctttgctc tctgcctcgt ctttccccag gacttcgcta ttttgctttt      120

ttaaaaaaag gcaagaaaga actaaactcc cccctccctc tcctccagtc gggctgcacc      180

tctgccttgc actttgcaca gaggtagaga gcgcgcgagg gagagagagg aaagaaaaaa      240

aataataaag agagccaagc agaagaggag gcgagaagca tgaagtgtta actcccccgt      300

gccaaggccc gcgccgcccg gacagacgcc cgccgcgcct ccagccccga gcggacgccg      360

cgcgcgccct gcctgcagcc cgggccggcg aggcgagccc ttccttatgc aaagcgcgca      420

gcggagcggc gagcggggga cgccgcgcac cgggccgggc tcctccagct tcgccgccgc      480

agccaccacc gccgccaccg cagctcgcgg aggatcttcc cgagcctgaa gccgccggct      540

cggcgcgcaa ggaggcgagc gagcaaggag gggccggggc gagcgaggga gcacattggc      600

gtgagcaggg gggagggagg gcgggcgcgg ggggcgcggg cagggcgggg gggtgtgtgt      660

gtgagcgcgc tcggaggttt cgggccagcc accgccgcgc aagctagaag cgccccagcc      720

cggcaagctg gctcacccgc tggccaccca gcacagcccg ctggcccctc tcctgcagcc      780

catctggcgg agcggcggcg gcggcggcgg cggcggcagg agaatggcat cagaactggc      840

aatgagcaac tccgacctgc ccaccagtcc cctggccatg gaatatgtta atgacttcga      900

tctgatgaag tttgaagtga aaaaggaacc ggtggagacc gaccgcatca tcagccagtg      960

cggccgtctc atcgccgggg gctcgctgtc ctccaccccc atgagcacgc cgtgcagctc     1020

ggtgccccct tcccccagct tctcggcgcc cagcccgggc tcgggcagcg agcagaaggc     1080

gcacctggaa gactactact ggatgaccgg ctacccgcag cagctgaacc ccgaggcgct     1140

gggcttcagc cccgaggacg cggtcgaggc gctcatcagc aacagccacc agctccaggg     1200

cggcttcgat ggctacgcgc gcggggcgca gcagctggcc gcggcggccg gggccggtgc     1260

cggcgcctcc ttgggcggca gcggcgagga gatgggcccc gccgccgccg tggtgtccgc     1320

cgtgatcgcc gcggccgccg cgcagagcgg cgcgggcccg cactaccacc accaccacca     1380

ccacgccgcc ggccaccacc accacccgac ggccggcgcg cccggcgccg cgggcagcgc     1440

ggccgcctcg gccggtggcg ctgggggcgc gggcggcggt ggcccggcca gcgctggggg     1500

cggcggcggc ggcggcggcg gcggaggcgg cgggggcgcg gcgggggcgg ggggcgccct     1560

gcacccgcac cacgccgccg gcggcctgca cttcgacgac cgcttctccg acgagcagct     1620

ggtgaccatg tctgtgcgcg agctgaaccg gcagctgcgc ggggtcagca aggaggaggt     1680

gatccggctg aagcagaaga ggcggaccct gaaaaaccgc ggctatgccc agtcctgccg     1740

cttcaagagg gtgcagcaga gacacgtcct ggagtcggag aagaaccagc tgctgcagca     1800

agtcgaccac ctcaagcagg agatctccag gctggtgcgc gagagggacg cgtacaagga     1860

gaaatacgag aagttggtga gcagcggctt ccgagaaaac ggctcgagca gcgacaaccc     1920

gtcctctccc gagtttttca taactgagcc cactcgcaag ttggagccat cagtgggata     1980

cgccacattt tggaagcccc agcatcgtgt acttaccagt gtgttcacaa aatgaaattt     2040

gtgtgagagc tgtacattaa aaaaaatcat cattattatt attatttgca gtcatggaga     2100

accacctacc cctgacttct gtttagtctc ctttttaaat aaaaattact gtgttagaga     2160

agaaggctat taaatgtagt agttaactat gcctcttgtc tgggggtttc atagagaccg     2220

gtaggaaagc gcactcctgc ttttcgattt atggtgtgtg caagtaaaca ggtgcattgc     2280

tttcaacctg ccatactagt tttaaaaatt cactgaaatt acaaagatac atatatatgc     2340

atatatataa tggaaagttt cccggaatgc aacaattagc attttaaaat catatatagg     2400

catgcacatt ctaaatagta ctttttcatg cttcattgtt tctctggcag ataattttac     2460

taagaagaaa aatagatatt cgactcccct tccctaaaca aatccacggg cagaggctcc     2520

agcggagccg agccccctgg ttttctcgta ggccctagac ggtgttgcat ttatcagtga     2580

tgtcaaacgt gctcatttgt cagacatagc tgtaaatgaa aacaatgtgt ggcaaaatac     2640

aaagttaaaa aaaaaa                                                     2656


<210>  3
<211>  6887
<212>  DNA
<213>  Homo sapiens

<400>  3
gaggctttaa aatctttttt catcttctag ctgtagctcg ggctgcttgt cggcttggcc       60

tccccctccc ccctttgctc tctgcctcgt ctttccccag gacttcgcta ttttgctttt      120

ttaaaaaaag gcaagaaaga actaaactcc cccctccctc tcctccagtc gggctgcacc      180

tctgccttgc actttgcaca gaggtagaga gcgcgcgagg gagagagagg aaagaaaaaa      240

aataataaag agagccaagc agaagaggag gcgagaagca tgaagtgtta actcccccgt      300

gccaaggccc gcgccgcccg gacagacgcc cgccgcgcct ccagccccga gcggacgccg      360

cgcgcgccct gcctgcagcc cgggccggcg aggcgagccc ttccttatgc aaagcgcgca      420

gcggagcggc gagcggggga cgccgcgcac cgggccgggc tcctccagct tcgccgccgc      480

agccaccacc gccgccaccg cagctcgcgg aggatcttcc cgagcctgaa gccgccggct      540

cggcgcgcaa ggaggcgagc gagcaaggag gggccggggc gagcgaggga gcacattggc      600

gtgagcaggg gggagggagg gcgggcgcgg ggggcgcggg cagggcgggg gggtgtgtgt      660

gtgagcgcgc tcggaggttt cgggccagcc accgccgcgc aagctagaag cgccccagcc      720

cggcaagctg gctcacccgc tggccaccca gcacagcccg ctggcccctc tcctgcagcc      780

catctggcgg agcggcggcg gcggcggcgg cggcggcagg agaatggcat cagaactggc      840

aatgagcaac tccgacctgc ccaccagtcc cctggccatg gaatatgtta atgacttcga      900

tctgatgaag tttgaagtga aaaaggaacc ggtggagacc gaccgcatca tcagccagtg      960

cggccgtctc atcgccgggg gctcgctgtc ctccaccccc atgagcacgc cgtgcagctc     1020

ggtgccccct tcccccagct tctcggcgcc cagcccgggc tcgggcagcg agcagaaggc     1080

gcacctggaa gactactact ggatgaccgg ctacccgcag cagctgaacc ccgaggcgct     1140

gggcttcagc cccgaggacg cggtcgaggc gctcatcagc aacagccacc agctccaggg     1200

cggcttcgat ggctacgcgc gcggggcgca gcagctggcc gcggcggccg gggccggtgc     1260

cggcgcctcc ttgggcggca gcggcgagga gatgggcccc gccgccgccg tggtgtccgc     1320

cgtgatcgcc gcggccgccg cgcagagcgg cgcgggcccg cactaccacc accaccacca     1380

ccacgccgcc ggccaccacc accacccgac ggccggcgcg cccggcgccg cgggcagcgc     1440

ggccgcctcg gccggtggcg ctgggggcgc gggcggcggt ggcccggcca gcgctggggg     1500

cggcggcggc ggcggcggcg gcggaggcgg cgggggcgcg gcgggggcgg ggggcgccct     1560

gcacccgcac cacgccgccg gcggcctgca cttcgacgac cgcttctccg acgagcagct     1620

ggtgaccatg tctgtgcgcg agctgaaccg gcagctgcgc ggggtcagca aggaggaggt     1680

gatccggctg aagcagaaga ggcggaccct gaaaaaccgc ggctatgccc agtcctgccg     1740

cttcaagagg gtgcagcaga gacacgtcct ggagtcggag aagaaccagc tgctgcagca     1800

agtcgaccac ctcaagcagg agatctccag gctggtgcgc gagagggacg cgtacaagga     1860

gaaatacgag aagttggtga gcagcggctt ccgagaaaac ggctcgagca gcgacaaccc     1920

gtcctctccc gagtttttca tgtgagtctg acacgcgatt ccagctagcc accctgataa     1980

gtgctccgcg ggggtccggc tcgggtgtgg gcttgctagt tctagagcca tgctcgccac     2040

cacctcacca cccccacccc caccgagttt ggcccccttg gccccctaca cacacacaaa     2100

cccgcacgca cacaccacac acacacacac acacacacac acaccccaca ccctgctcga     2160

gtttgtggtg gtggtggctg ttttaaactg gggagggaat gggtgtctgg ctcatggatt     2220

gccaatctga aattctccat aacttgctag cttgtttttt tttttttttt acaccccccc     2280

gccccacccc cggacttgca caatgttcaa tgatctcagc agagttcttc atgtgaaacg     2340

ttgatcacct ttgaagcctg catcattcac atattttttc ttcttcttcc ccttcagttc     2400

atgaactggt gttcattttc tgtgtgtgtg tgtgttttat tttgtttgga tttttttttt     2460

taattttact tttagagctt gctgtgttgc ccaccttttt tccaacctcc accctcactc     2520

cttctcaacc catctcttcc gagatgaaag aaaaaaaaaa gcaaagtttt tttttcttct     2580

cctgagttct tcatgtgaga ttgagcttgc aaaggaaaaa aaaatgtgaa atgttataga     2640

cttgcagcgt gccgagttcc atcgggtttt ttttttagca ttgttatgct aaaatagaga     2700

aaaaaatcct catgaacctt ccacaatcaa gcctgcatca accttctggg tgtgacttgt     2760

gagttttggc cttgtgatgc caaatctgag agtttagtct gccattaaaa aaactcattc     2820

tcatctcatg cattattatg cttgctactt tgtcttagca acaatgaact ataactgttt     2880

caaagacttt atggaaaaga gacattatat taataaaaaa aaaaagcctg catgctggac     2940

atgtatggta taattatttt ttcctttttt tttccttttg gcttggaaat ggacgttcga     3000

agacttatag catggcattc atacttttgt tttattgcct catgactttt ttgagtttag     3060

aacaaaacag tgcaaccgta gagccttctt cccatgaaat tttgcatctg ctccaaaact     3120

gctttgagtt actcagaact tcaacctccc aatgcactga aggcattcct tgtcaaagat     3180

accagaatgg gttacacatt taacctggca aacattgaag aactcttaat gttttctttt     3240

taataagaat gacgccccac tttggggact aaaattgtgc tattgccgag aagcagtcta     3300

aaatttattt tttaaaaaga gaaactgccc cattattttt ggtttgtttt atttttattt     3360

tatatttttt ggcttttggt cattgtcaaa tgtggaatgc tctgggtttc tagtatataa     3420

tttaattcta gtttttataa tctgttagcc cagttaaaat gtatgctaca gataaaggaa     3480

tgttatagat aaatttgaaa gagttaggtc tgtttagctg tagatttttt aaacgattga     3540

tgcactaaat tgtttactat tgtgatgtta aggggggtag agtttgcaag gggactgttt     3600

aaaaaaagta gcttatacag catgtgcttg caacttaaat ataagttggg tatgtgtagt     3660

ctttgctata ccactgactg tattgaaaac caaagtatta agaggggaaa cgcccctgtt     3720

tatatctgta ggggtatttt acattcaaaa atgtatgttt ttttttcttt tcaaaattaa     3780

agtatttggg actgaattgc actaagatat aacctgcaag catataatac aaaaaaaaat     3840

tgcaaaactg tttagaacgc taataaaatt tatgcagtta taaaaatggc attactgcac     3900

agttttaaga tgatgcagat ttttttacag ttgtattgtg gtgcagaact ggattttctg     3960

taacttaaaa aaaaatccac agttttaaag gcaataatca gtaaatgtta ttttcaggga     4020

ctgacatcct gtctttaaaa agaaatgaaa agtaaatctt accacaataa atataaaaaa     4080

atcttgtcag ttacttttct tttacatatt ttgctgtgca aaattgtttt atatcttgag     4140

ttactaacta accacgcgtg ttgttcctat gtgcttttct ttcattttca attctggtta     4200

tatcaagaaa agaataatct acaataataa acggcatttt tttttgattc tgtactcagt     4260

ttcttagtgt acagtttaac tgggcccaac aacctcgtta aaagtgtaaa atgcatcctt     4320

ttctccagtg gaaggattcc tggaggaata gggagacagt aattcagggt gaaattatag     4380

gctgtttttt gaagtgagga ggctggcccc atatactgat tagcaatatt taatatagat     4440

gtaaattatg acctcatttt tttctcccca aagttttcag ttttcaaatg agttgagcca     4500

taattgccct tggtaggaaa aacaaaacaa aacagtggaa ctaggcttcc tgagcatggc     4560

cctacacttc tgatcaggag caaagccatc catagacaga ggagccggac aaatatggcg     4620

catcagaggt ggcttgcgca catatgcatt gaacggtaaa gagaaacagc gcttgccttt     4680

tcactaaagt tgactatttt tccttcttct cttacacacc gagattttct tgttagcaag     4740

gcctgacaag atttaacata aacatgacaa atcatagttg tttgttttgt tttgcttttc     4800

tctttaacac tgaagatcat ttgtcttaaa taggaaaaag aaaatccact ccttacttcc     4860

atatttccaa gtacatatct ggtttaaact atgttatcaa atcatatttc accgtgaata     4920

ttcagtggag aacttctcta cctggatgag ctagtaatga tttcagatca tgctatcccc     4980

agaaataaaa gcaaaaaata atacctgtgt ggaatatagg ctgtgctttg atttactggt     5040

atttacccca aaataggctg tgtatggggg ctgacttaaa gatcccttgg aaagactcaa     5100

aactaccttc actagtagga ctcctaagcg ctgacctatt tttaaatgac acaaattcat     5160

gaaactaatg ttacaaattc atgcagtttg cactcttagt catcttcccc tagcacacca     5220

atagaatgtt agacaaagcc agcactgttt tgaaaataca gccaaacacg atgacttttg     5280

ttttgttttc tgccgttctt aaaagaaaaa aagataatat tgcaactctg actgaaagac     5340

ttatttttaa gaaaacaggt tgtgtttggt gctgctaagt tctggccagt ttatcatctg     5400

gccttcctgc ctatttttta caaaacacga agacagtgtg taacctcgac attttgacct     5460

tcctttatgt gctagtttag acaggctcct gaatccacac ttaattttgc ttaacaaaag     5520

tcttaatagt aaacctcccc tcatgagctt gaagtcaagt gttcttgact tcagatattt     5580

ctttcctttt tttttttttt tcctcatcac aactaagaga tacacaaact ctgaagaagc     5640

agaaatggag agaatgcttt taacaaaaaa gcatctgatg aaagatttta ggcaaacatt     5700

ctcaaaataa gagtgatatt ctggatgtag ttattgcagt tatctcatga caaatgaggc     5760

ctggattgga aggaaaatat agttgtgtag aattaagcat tttgatagga atctacaagg     5820

tagttgaata taataagcag gtttgggccc ccaaacttta gaaaatcaaa tgcaaaggtg     5880

ctggcaaaaa tgaggtttga gtggctggct gtaagagaag gttaactcct agtaaaaggc     5940

atttttagaa ataacaatta ctgaaaactt tgaagtatag tgggagtagc aaacaaatac     6000

atgttttttt tttcttacaa agaactccta aatcctgagt aagtgccatt cattacaata     6060

agtctctaaa tttaaaaaaa aaaaaatcat atgaggaaat ctagctttcc cctttacgct     6120

gcgtttgatc tttgtctaaa tagtgttaaa attcctttca ttccaattac agaactgagc     6180

ccactcgcaa gttggagcca tcagtgggat acgccacatt ttggaagccc cagcatcgtg     6240

tacttaccag tgtgttcaca aaatgaaatt tgtgtgagag ctgtacatta aaaaaaatca     6300

tcattattat tattatttgc agtcatggag aaccacctac ccctgacttc tgtttagtct     6360

cctttttaaa taaaaattac tgtgttagag aagaaggcta ttaaatgtag tagttaacta     6420

tgcctcttgt ctgggggttt catagagacc ggtaggaaag cgcactcctg cttttcgatt     6480

tatggtgtgt gcaagtaaac aggtgcattg ctttcaacct gccatactag ttttaaaaat     6540

tcactgaaat tacaaagata catatatatg catatatata atggaaagtt tcccggaatg     6600

caacaattag cattttaaaa tcatatatag gcatgcacat tctaaatagt actttttcat     6660

gcttcattgt ttctctggca gataatttta ctaagaagaa aaatagatat tcgactcccc     6720

ttccctaaac aaatccacgg gcagaggctc cagcggagcc gagccccctg gttttctcgt     6780

aggccctaga cggtgttgca tttatcagtg atgtcaaacg tgctcatttg tcagacatag     6840

ctgtaaatga aaacaatgtg tggcaaaata caaagttaaa aaaaaaa                   6887


<210>  4
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ser Glu Leu Ala Met Ser Asn Ser Asp Leu Pro Thr Ser Pro 
1               5                   10                  15      


Leu Ala Met Glu Tyr Val Asn Asp Phe Asp Leu Met Lys Phe Glu Val 
            20                  25                  30          


Lys Lys Glu Pro Val Glu Thr Asp Arg Ile Ile Ser Gln Cys Gly Arg 
        35                  40                  45              


Leu Ile Ala Gly Gly Ser Leu Ser Ser Thr Pro Met Ser Thr Pro Cys 
    50                  55                  60                  


Ser Ser Val Pro Pro Ser Pro Ser Phe Ser Ala Pro Ser Pro Gly Ser 
65                  70                  75                  80  


Gly Ser Glu Gln Lys Ala His Leu Glu Asp Tyr Tyr Trp Met Thr Gly 
                85                  90                  95      


Tyr Pro Gln Gln Leu Asn Pro Glu Ala Leu Gly Phe Ser Pro Glu Asp 
            100                 105                 110         


Ala Val Glu Ala Leu Ile Ser Asn Ser His Gln Leu Gln Gly Gly Phe 
        115                 120                 125             


Asp Gly Tyr Ala Arg Gly Ala Gln Gln Leu Ala Ala Ala Ala Gly Ala 
    130                 135                 140                 


Gly Ala Gly Ala Ser Leu Gly Gly Ser Gly Glu Glu Met Gly Pro Ala 
145                 150                 155                 160 


Ala Ala Val Val Ser Ala Val Ile Ala Ala Ala Ala Ala Gln Ser Gly 
                165                 170                 175     


Ala Gly Pro His Tyr His His His His His His Ala Ala Gly His His 
            180                 185                 190         


His His Pro Thr Ala Gly Ala Pro Gly Ala Ala Gly Ser Ala Ala Ala 
        195                 200                 205             


Ser Ala Gly Gly Ala Gly Gly Ala Gly Gly Gly Gly Pro Ala Ser Ala 
    210                 215                 220                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Ala 
225                 230                 235                 240 


Gly Ala Gly Gly Ala Leu His Pro His His Ala Ala Gly Gly Leu His 
                245                 250                 255     


Phe Asp Asp Arg Phe Ser Asp Glu Gln Leu Val Thr Met Ser Val Arg 
            260                 265                 270         


Glu Leu Asn Arg Gln Leu Arg Gly Val Ser Lys Glu Glu Val Ile Arg 
        275                 280                 285             


Leu Lys Gln Lys Arg Arg Thr Leu Lys Asn Arg Gly Tyr Ala Gln Ser 
    290                 295                 300                 


Cys Arg Phe Lys Arg Val Gln Gln Arg His Val Leu Glu Ser Glu Lys 
305                 310                 315                 320 


Asn Gln Leu Leu Gln Gln Val Asp His Leu Lys Gln Glu Ile Ser Arg 
                325                 330                 335     


Leu Val Arg Glu Arg Asp Ala Tyr Lys Glu Lys Tyr Glu Lys Leu Val 
            340                 345                 350         


Ser Ser Gly Phe Arg Glu Asn Gly Ser Ser Ser Asp Asn Pro Ser Ser 
        355                 360                 365             


Pro Glu Phe Phe Ile Thr Glu Pro Thr Arg Lys Leu Glu Pro Ser Val 
    370                 375                 380                 


Gly Tyr Ala Thr Phe Trp Lys Pro Gln His Arg Val Leu Thr Ser Val 
385                 390                 395                 400 


Phe Thr Lys 
            


<210>  5
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Ser Glu Leu Ala Met Ser Asn Ser Asp Leu Pro Thr Ser Pro 
1               5                   10                  15      


Leu Ala Met Glu Tyr Val Asn Asp Phe Asp Leu Met Lys Phe Glu Val 
            20                  25                  30          


Lys Lys Glu Pro Val Glu Thr Asp Arg Ile Ile Ser Gln Cys Gly Arg 
        35                  40                  45              


Leu Ile Ala Gly Gly Ser Leu Ser Ser Thr Pro Met Ser Thr Pro Cys 
    50                  55                  60                  


Ser Ser Val Pro Pro Ser Pro Ser Phe Ser Ala Pro Ser Pro Gly Ser 
65                  70                  75                  80  


Gly Ser Glu Gln Lys Ala His Leu Glu Asp Tyr Tyr Trp Met Thr Gly 
                85                  90                  95      


Tyr Pro Gln Gln Leu Asn Pro Glu Ala Leu Gly Phe Ser Pro Glu Asp 
            100                 105                 110         


Ala Val Glu Ala Leu Ile Ser Asn Ser His Gln Leu Gln Gly Gly Phe 
        115                 120                 125             


Asp Gly Tyr Ala Arg Gly Ala Gln Gln Leu Ala Ala Ala Ala Gly Ala 
    130                 135                 140                 


Gly Ala Gly Ala Ser Leu Gly Gly Ser Gly Glu Glu Met Gly Pro Ala 
145                 150                 155                 160 


Ala Ala Val Val Ser Ala Val Ile Ala Ala Ala Ala Ala Gln Ser Gly 
                165                 170                 175     


Ala Gly Pro His Tyr His His His His His His Ala Ala Gly His His 
            180                 185                 190         


His His Pro Thr Ala Gly Ala Pro Gly Ala Ala Gly Ser Ala Ala Ala 
        195                 200                 205             


Ser Ala Gly Gly Ala Gly Gly Ala Gly Gly Gly Gly Pro Ala Ser Ala 
    210                 215                 220                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Ala 
225                 230                 235                 240 


Gly Ala Gly Gly Ala Leu His Pro His His Ala Ala Gly Gly Leu His 
                245                 250                 255     


Phe Asp Asp Arg Phe Ser Asp Glu Gln Leu Val Thr Met Ser Val Arg 
            260                 265                 270         


Glu Leu Asn Arg Gln Leu Arg Gly Val Ser Lys Glu Glu Val Ile Arg 
        275                 280                 285             


Leu Lys Gln Lys Arg Arg Thr Leu Lys Asn Arg Gly Tyr Ala Gln Ser 
    290                 295                 300                 


Cys Arg Phe Lys Arg Val Gln Gln Arg His Val Leu Glu Ser Glu Lys 
305                 310                 315                 320 


Asn Gln Leu Leu Gln Gln Val Asp His Leu Lys Gln Glu Ile Ser Arg 
                325                 330                 335     


Leu Val Arg Glu Arg Asp Ala Tyr Lys Glu Lys Tyr Glu Lys Leu Val 
            340                 345                 350         


Ser Ser Gly Phe Arg Glu Asn Gly Ser Ser Ser Asp Asn Pro Ser Ser 
        355                 360                 365             


Pro Glu Phe Phe Met 
    370             


<210>  6
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  c-MAF specific siRNA

<400>  6
acggcucgag cagcgacaa                                                    19


<210>  7
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  c-MAF specific siRNA

<400>  7
cuuaccagug uguucacaa                                                    19


<210>  8
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  c-MAF specific siRNA

<400>  8
uggaagacua cuacuggaug                                                   20


<210>  9
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  c-MAF specific siRNA

<400>  9
auuugcaguc auggagaacc                                                   20


<210>  10
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  c-MAF specific siRNA

<400>  10
caaggagaaa uacgagaagu                                                   20


<210>  11
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  c-MAF specific siRNA

<400>  11
acaaggagaa auacgagaag                                                   20


<210>  12
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  c-MAF specific siRNA

<400>  12
accuggaaga cuacuacugg                                                   20


<210>  13
<211>  13878
<212>  DNA
<213>  Homo sapiens

<400>  13
aactatatat taaacacctc cggtctgaga ggccgtgttg ggtgtctttg tcaggtgaag       60

aaagagaaga aggctggtac accttcccag gaattctcac tgaagaaaac atctggattt      120

tttacatctc ttgtgcaaaa caaacaaaga tttcattaag tgatgtatat tgttttccaa      180

ggaagaaacc tgcagagaca aaaacaaata agcaaataat tgaaacaaaa atatgataaa      240

cccccaaatt cttccagtgc taatttactt gttatcatgg ttctctacaa aggcagagat      300

cactaattac aggtttttcc agaattcaca tttcacgtca agatcatcca atccaaacag      360

tgtacggaaa gcctagggcc ttcttcactt tgccccctac cccaccctac acacacgccc      420

ccatctaaat gatacccttg gaaagaaacc tacacatctc atttgtctat attttgcttc      480

ctccctcgcc tcccggtaac caaatgtgag ttgttctcta actgcactgg agaatcagaa      540

tttattgtac atatgtttgt gttccactta ataaaaaaac ctatatttta agataaactt      600

tgttagtaat tcatgaggta agtgactatt tatgctaatc aggcagaaat atattctcaa      660

gcataatgca ttacataaat ttgaatgtaa aatgttcaat tatgaagtaa atacaggtaa      720

tgcaaataat aaattacctc taataaaaat tataaaagat gtgccttgaa agagagagcg      780

gctttaactt acaactgtga attgcttaaa gagaaaagaa ttaataaatg ctgaattact      840

ctgatgatta tttagcacat aattcaccta ttcataacga ctcctagtaa tcagactgtt      900

gtttcacatc ctccaacatg aggcaagact gtttcctcag caattttgcc cttatcagat      960

tatctcgtct gattctatta attttcttcc atgaatctgc taacagtgat ttgtgattta     1020

cttaccctgc taactgaaga ctgttaaaag gatttatcta acactggacc taagaacagt     1080

gtacgcctta tcgttcagtt actctgaaga actctttctc aaatcaattt agttggtttc     1140

atagtgaaat ttagtggaca ctggttagtt ctgccccata aaatcagccc ctaaacaaag     1200

agtccagaca ccatacctga tgcatcccat tctattcaga ttatggatgt ctgattccaa     1260

catgatatat ttgagttgct ataactcaca atcggggaaa atatattcct ttaagctttt     1320

aatctttgta atttggacat gaacaggggt tttgtttttc atttttgcat gaagtcatta     1380

tgtatgtact gacgtgaaac tataattgtg tttctgatgt tactgtgtca caatattcta     1440

tgcgatgtaa cccatgtcct cctccccctc acaaatctcc tataaatatt cattgctttc     1500

aaaaacttta atactactgg tccgaattgg tcaataatga caaatgcatg gtttctaaat     1560

tactgtatat tgttctacag agattactag agtatatata gcaaggggat gttaagcagt     1620

aagaaaacac agttcacatt gtatttggat tagattggct tggatagaag tgaaacaaac     1680

aatgttagca aagaagtcta aagacatgtg gcccactgta attgtacaga atcaaaaacc     1740

tgaatagtac tcattaaaat gagagagctc aattgttata aaagaaatgc tgctaacaga     1800

gaactgtaaa tgtttagaca cccctgtgaa tcactaaata ataatgtaaa aaggataaaa     1860

atgagaatta agttataagc ctgagagcat tactgctaca catctaaaaa aataattctg     1920

atcctctctt ttttttttcc aagagaaaat gggcgactat aaaagacctt gcaataagag     1980

aaataaaaat accatgtctt cacagcagtg tacataaata aaccataaaa atgtgcagat     2040

aataatatat ttagctgccc aaacatgggc atttaatttc tagaaatgat atataacaat     2100

gtaacaatta gatactcagc catgaatgtg tatggcacag tcttcatcat tagcaaactt     2160

tgtgtataaa atattattta ttatttatta taatactgct ttcagaggca atgatcatac     2220

cttacagctt ttaacacaaa tatgatgcaa aaggattaaa agtatatcat aaacaaacaa     2280

taaattcttt ctaaatacac ttaaattcat attttacatg aaaaatataa acttcctaca     2340

tttgtgacta ctgactttta aaaagaccta gaaaactatt gttacgggca atgttaaatg     2400

acataatgct tatgtaatgg aaagtgtgga ttttcctcta aataaactat aatcccttaa     2460

cttcattact agggaaaata ttgttaaaga gaaggaaagc aagggaattc tgctaggttg     2520

cataaatatt gacataatct tcactctttc ttccccaaac tggtaataga catagtttat     2580

tccacccaac aaaatgctct tataagacca aaactaccct tattaacaac ttctctgcag     2640

tcacgatgaa aagaaacact acttgtctga aaaataccga cagcgctgcc cttttcagat     2700

tagggtgtgc ctacgaatct tttgggaagt cttccattaa ggattcctgg gtttgctgaa     2760

actgaagtct actaggatca gagaaattaa cacaggtcta atatggtgca aggaacgagt     2820

gagagacacc tgaggttata aatagcaaag catgctgcgg ggtggggaag accattctga     2880

agtgcaatgt tcaagacgct ggcttaatat atgactaagt gtcagaagtc aggttttctg     2940

agaattactt tccagataaa caactttata gcactgcact taatcttact tactagagac     3000

atctcattta tcactgaatt acaagtaact ttaatcctat tgatattgcc ataaagcccg     3060

ttgaaaatcc atcctggcac ttttaaaggg tttggggccc tgttacatgg ggatcctctt     3120

gcaaaggtct cagccagaaa ttacaccccg agggtgtctg tatcccctgg cctctttgtc     3180

aacaatcaag gagaagagga ggggcaaaaa tgatctctgc atctgccagc actttcttcg     3240

gcccctttcc tatagggtcg ggttctccca cttcagtcaa actaactttg tgtgtctctt     3300

tcctcctccc acactgggta accagctgct tttcacttca tcgacaaaac tggacacgga     3360

tcaatttcaa ctgacctttg ccgaaaggtg gcgctgttga ggtaaaaacc aactcgctcc     3420

aacaatagtt tccactcttc gatccttttg caggcttttc agaatttttt ttttttttta     3480

atgcaccctc ctagcgtctc ccccttctca taaagtaaaa taaatacgat taaaaacacc     3540

aaatgcattt cattaattga aggaatcaac agtcccaact tctaagcaga cgggctggtc     3600

ttccaaaggc tgggtcggtt tcaggagctt tctctccaaa taaatctctg cttcttcgac     3660

ttgcctatcg ctttaaaatc ttagaaacag agttagttgt tggtttcctt cttttttctt     3720

tttctttttt atttcttttt tgcataaact tttagagaat caatctagaa atttgaacta     3780

cttattagca tttgcaactg ggggtggggg gagcagcctc ccccacccca ccccccactc     3840

tgcgtttccg gactagttcc agaaaccgcg gtttaaaatt taacccttcg agggtagctg     3900

gtgagggctg gggtattgtt tttccccctt gctccctgcc acgatcaagt ccgaaataat     3960

taaaggaaac gtaaaagtgc aaagggcgcg cctgaccctg ataaacagag gtcagatttc     4020

gtaaggggac gggtgagtgt gagtgtgtgt gtgtttgtgt gtgtgtgtgt aagagagaga     4080

gagagcgagc gcgcaatatg agtctcaaag gccaaactcc ggccagtcag gagccggaag     4140

gctgagcccg gctgacctga ctttgagctt ccccggagtt atctcgcata ggcgctcgct     4200

ctgtccaagg gcacgcgacg ccagcgggca gccggtctcc gtgaagaatg gcctctaaac     4260

aacttatttt acctcgttgt aaagagaggg ataaaatggg ctttccctct ccacggatgc     4320

ccagccttct gggcaggcgc atggccgggc ggcgcccagc ccgcagcccc gatccggaca     4380

ccccactgca tccctccctt cccggtccct tccccgcacg ggcgcccgag agacggacaa     4440

agagttgggg ccaagtttga gcgccgggca cggccaggct cagggaagga aggtccccgg     4500

cagacacctg ggtaccagag ttggtgcgag gaggaaaagc tgggaggcga attcacaatc     4560

ctgggggtgg agggcaggca ggggagggga atcaggccaa tcccagccga gtgagccccc     4620

agcgagctgg ggctccggat gggaggcctg tctcgcgctc caaagaaaag caaaccgccc     4680

tcccaggtcc gcccggattg ccgaagcccc tctggaaaaa ctccttcccc tcttacacca     4740

aactttgcgc cgggcctcgt tccctcccgg gtaggcagcg gcgcaggaag ggttaagcca     4800

gcccgtccca gctgacagtc agctgattgg gccctgattg acagctccga aaagtttcct     4860

tgtttctata ctattatgct aatcgcggcc gctctcgccg cctcccattg gcccggagtg     4920

ccagtcaatt tctcatttgg acctgacgtc acgagtgcta taaaactcag caattgcttt     4980

aaactcttct tgctggatca gaggctttaa aatctttttt catcttctag ctgtagctcg     5040

ggctgcttgt cggcttggcc tccccctccc ccctttgctc tctgcctcgt ctttccccag     5100

gacttcgcta ttttgctttt ttaaaaaaag gcaagaaaga actaaactcc cccctccctc     5160

tcctccagtc gggctgcacc tctgccttgc actttgcaca gaggtagaga gcgcgcgagg     5220

gagagagagg aaagaaaaaa aataataaag agagccaagc agaagaggag gcgagaagca     5280

tgaagtgtta actcccccgt gccaaggccc gcgccgcccg gacagacgcc cgccgcgcct     5340

ccagccccga gcggacgccg cgcgcgccct gcctgcagcc cgggccggcg aggcgagccc     5400

ttccttatgc aaagcgcgca gcggagcggc gagcggggga cgccgcgcac cgggccgggc     5460

tcctccagct tcgccgccgc agccaccacc gccgccaccg cagctcgcgg aggatcttcc     5520

cgagcctgaa gccgccggct cggcgcgcaa ggaggcgagc gagcaaggag gggccggggc     5580

gagcgaggga gcacattggc gtgagcaggg gggagggagg gcgggcgcgg ggggcgcggg     5640

cagggcgggg gggtgtgtgt gtgagcgcgc tcggaggttt cgggccagcc accgccgcgc     5700

aagctagaag cgccccagcc cggcaagctg gctcacccgc tggccaccca gcacagcccg     5760

ctggcccctc tcctgcagcc catctggcgg agcggcggcg gcggcggcgg cggcggcagg     5820

agaatggcat cagaactggc aatgagcaac tccgacctgc ccaccagtcc cctggccatg     5880

gaatatgtta atgacttcga tctgatgaag tttgaagtga aaaaggaacc ggtggagacc     5940

gaccgcatca tcagccagtg cggccgtctc atcgccgggg gctcgctgtc ctccaccccc     6000

atgagcacgc cgtgcagctc ggtgccccct tcccccagct tctcggcgcc cagcccgggc     6060

tcgggcagcg agcagaaggc gcacctggaa gactactact ggatgaccgg ctacccgcag     6120

cagctgaacc ccgaggcgct gggcttcagc cccgaggacg cggtcgaggc gctcatcagc     6180

aacagccacc agctccaggg cggcttcgat ggctacgcgc gcggggcgca gcagctggcc     6240

gcggcggccg gggccggtgc cggcgcctcc ttgggcggca gcggcgagga gatgggcccc     6300

gccgccgccg tggtgtccgc cgtgatcgcc gcggccgccg cgcagagcgg cgcgggcccg     6360

cactaccacc accaccacca ccacgccgcc ggccaccacc accacccgac ggccggcgcg     6420

cccggcgccg cgggcagcgc ggccgcctcg gccggtggcg ctgggggcgc gggcggcggt     6480

ggcccggcca gcgctggggg cggcggcggc ggcggcggcg gcggaggcgg cgggggcgcg     6540

gcgggggcgg ggggcgccct gcacccgcac cacgccgccg gcggcctgca cttcgacgac     6600

cgcttctccg acgagcagct ggtgaccatg tctgtgcgcg agctgaaccg gcagctgcgc     6660

ggggtcagca aggaggaggt gatccggctg aagcagaaga ggcggaccct gaaaaaccgc     6720

ggctatgccc agtcctgccg cttcaagagg gtgcagcaga gacacgtcct ggagtcggag     6780

aagaaccagc tgctgcagca agtcgaccac ctcaagcagg agatctccag gctggtgcgc     6840

gagagggacg cgtacaagga gaaatacgag aagttggtga gcagcggctt ccgagaaaac     6900

ggctcgagca gcgacaaccc gtcctctccc gagtttttca tgtgagtctg acacgcgatt     6960

ccagctagcc accctgataa gtgctccgcg ggggtccggc tcgggtgtgg gcttgctagt     7020

tctagagcca tgctcgccac cacctcacca cccccacccc caccgagttt ggcccccttg     7080

gccccctaca cacacacaaa cccgcacgca cacaccacac acacacacac acacacacac     7140

acaccccaca ccctgctcga gtttgtggtg gtggtggctg ttttaaactg gggagggaat     7200

gggtgtctgg ctcatggatt gccaatctga aattctccat aacttgctag cttgtttttt     7260

tttttttttt acaccccccc gccccacccc cggacttgca caatgttcaa tgatctcagc     7320

agagttcttc atgtgaaacg ttgatcacct ttgaagcctg catcattcac atattttttc     7380

ttcttcttcc ccttcagttc atgaactggt gttcattttc tgtgtgtgtg tgtgttttat     7440

tttgtttgga tttttttttt taattttact tttagagctt gctgtgttgc ccaccttttt     7500

tccaacctcc accctcactc cttctcaacc catctcttcc gagatgaaag aaaaaaaaaa     7560

gcaaagtttt tttttcttct cctgagttct tcatgtgaga ttgagcttgc aaaggaaaaa     7620

aaaatgtgaa atgttataga cttgcagcgt gccgagttcc atcgggtttt ttttttagca     7680

ttgttatgct aaaatagaga aaaaaatcct catgaacctt ccacaatcaa gcctgcatca     7740

accttctggg tgtgacttgt gagttttggc cttgtgatgc caaatctgag agtttagtct     7800

gccattaaaa aaactcattc tcatctcatg cattattatg cttgctactt tgtcttagca     7860

acaatgaact ataactgttt caaagacttt atggaaaaga gacattatat taataaaaaa     7920

aaaaagcctg catgctggac atgtatggta taattatttt ttcctttttt tttccttttg     7980

gcttggaaat ggacgttcga agacttatag catggcattc atacttttgt tttattgcct     8040

catgactttt ttgagtttag aacaaaacag tgcaaccgta gagccttctt cccatgaaat     8100

tttgcatctg ctccaaaact gctttgagtt actcagaact tcaacctccc aatgcactga     8160

aggcattcct tgtcaaagat accagaatgg gttacacatt taacctggca aacattgaag     8220

aactcttaat gttttctttt taataagaat gacgccccac tttggggact aaaattgtgc     8280

tattgccgag aagcagtcta aaatttattt tttaaaaaga gaaactgccc cattattttt     8340

ggtttgtttt atttttattt tatatttttt ggcttttggt cattgtcaaa tgtggaatgc     8400

tctgggtttc tagtatataa tttaattcta gtttttataa tctgttagcc cagttaaaat     8460

gtatgctaca gataaaggaa tgttatagat aaatttgaaa gagttaggtc tgtttagctg     8520

tagatttttt aaacgattga tgcactaaat tgtttactat tgtgatgtta aggggggtag     8580

agtttgcaag gggactgttt aaaaaaagta gcttatacag catgtgcttg caacttaaat     8640

ataagttggg tatgtgtagt ctttgctata ccactgactg tattgaaaac caaagtatta     8700

agaggggaaa cgcccctgtt tatatctgta ggggtatttt acattcaaaa atgtatgttt     8760

ttttttcttt tcaaaattaa agtatttggg actgaattgc actaagatat aacctgcaag     8820

catataatac aaaaaaaaat tgcaaaactg tttagaacgc taataaaatt tatgcagtta     8880

taaaaatggc attactgcac agttttaaga tgatgcagat ttttttacag ttgtattgtg     8940

gtgcagaact ggattttctg taacttaaaa aaaaatccac agttttaaag gcaataatca     9000

gtaaatgtta ttttcaggga ctgacatcct gtctttaaaa agaaatgaaa agtaaatctt     9060

accacaataa atataaaaaa atcttgtcag ttacttttct tttacatatt ttgctgtgca     9120

aaattgtttt atatcttgag ttactaacta accacgcgtg ttgttcctat gtgcttttct     9180

ttcattttca attctggtta tatcaagaaa agaataatct acaataataa acggcatttt     9240

tttttgattc tgtactcagt ttcttagtgt acagtttaac tgggcccaac aacctcgtta     9300

aaagtgtaaa atgcatcctt ttctccagtg gaaggattcc tggaggaata gggagacagt     9360

aattcagggt gaaattatag gctgtttttt gaagtgagga ggctggcccc atatactgat     9420

tagcaatatt taatatagat gtaaattatg acctcatttt tttctcccca aagttttcag     9480

ttttcaaatg agttgagcca taattgccct tggtaggaaa aacaaaacaa aacagtggaa     9540

ctaggcttcc tgagcatggc cctacacttc tgatcaggag caaagccatc catagacaga     9600

ggagccggac aaatatggcg catcagaggt ggcttgcgca catatgcatt gaacggtaaa     9660

gagaaacagc gcttgccttt tcactaaagt tgactatttt tccttcttct cttacacacc     9720

gagattttct tgttagcaag gcctgacaag atttaacata aacatgacaa atcatagttg     9780

tttgttttgt tttgcttttc tctttaacac tgaagatcat ttgtcttaaa taggaaaaag     9840

aaaatccact ccttacttcc atatttccaa gtacatatct ggtttaaact atgttatcaa     9900

atcatatttc accgtgaata ttcagtggag aacttctcta cctggatgag ctagtaatga     9960

tttcagatca tgctatcccc agaaataaaa gcaaaaaata atacctgtgt ggaatatagg    10020

ctgtgctttg atttactggt atttacccca aaataggctg tgtatggggg ctgacttaaa    10080

gatcccttgg aaagactcaa aactaccttc actagtagga ctcctaagcg ctgacctatt    10140

tttaaatgac acaaattcat gaaactaatg ttacaaattc atgcagtttg cactcttagt    10200

catcttcccc tagcacacca atagaatgtt agacaaagcc agcactgttt tgaaaataca    10260

gccaaacacg atgacttttg ttttgttttc tgccgttctt aaaagaaaaa aagataatat    10320

tgcaactctg actgaaagac ttatttttaa gaaaacaggt tgtgtttggt gctgctaagt    10380

tctggccagt ttatcatctg gccttcctgc ctatttttta caaaacacga agacagtgtg    10440

taacctcgac attttgacct tcctttatgt gctagtttag acaggctcct gaatccacac    10500

ttaattttgc ttaacaaaag tcttaatagt aaacctcccc tcatgagctt gaagtcaagt    10560

gttcttgact tcagatattt ctttcctttt tttttttttt tcctcatcac aactaagaga    10620

tacacaaact ctgaagaagc agaaatggag agaatgcttt taacaaaaaa gcatctgatg    10680

aaagatttta ggcaaacatt ctcaaaataa gagtgatatt ctggatgtag ttattgcagt    10740

tatctcatga caaatgaggc ctggattgga aggaaaatat agttgtgtag aattaagcat    10800

tttgatagga atctacaagg tagttgaata taataagcag gtttgggccc ccaaacttta    10860

gaaaatcaaa tgcaaaggtg ctggcaaaaa tgaggtttga gtggctggct gtaagagaag    10920

gttaactcct agtaaaaggc atttttagaa ataacaatta ctgaaaactt tgaagtatag    10980

tgggagtagc aaacaaatac atgttttttt tttcttacaa agaactccta aatcctgagt    11040

aagtgccatt cattacaata agtctctaaa tttaaaaaaa aaaaaatcat atgaggaaat    11100

ctagctttcc cctttacgct gcgtttgatc tttgtctaaa tagtgttaaa attcctttca    11160

ttccaattac agaactgagc ccactcgcaa gttggagcca tcagtgggat acgccacatt    11220

ttggaagccc cagcatcgtg tacttaccag tgtgttcaca aaatgaaatt tgtgtgagag    11280

ctgtacatta aaaaaaatca tcattattat tattatttgc agtcatggag aaccacctac    11340

ccctgacttc tgtttagtct cctttttaaa taaaaattac tgtgttagag aagaaggcta    11400

ttaaatgtag tagttaacta tgcctcttgt ctgggggttt catagagacc ggtaggaaag    11460

cgcactcctg cttttcgatt tatggtgtgt gcaagtaaac aggtgcattg ctttcaacct    11520

gccatactag ttttaaaaat tcactgaaat tacaaagata catatatatg catatatata    11580

atggaaagtt tcccggaatg caacaattag cattttaaaa tcatatatag gcatgcacat    11640

tctaaatagt actttttcat gcttcattgt ttctctggca gataatttta ctaagaagaa    11700

aaatagatat tcgactcccc ttccctaaac aaatccacgg gcagaggctc cagcggagcc    11760

gagccccctg gttttctcgt aggccctaga cggtgttgca tttatcagtg atgtcaaacg    11820

tgctcatttg tcagacatag ctgtaaatga aaacaatgtg tggcaaaata caaagttagt    11880

taaatacaca ccctctgtgt gattttttgc tcccttttct tttttgctcc tactcaaaaa    11940

aaaaaaaatc acctccttta catttccctg gcttcttgca tgtttccctt ttcaaaaacc    12000

atgtaataat tttttacaat gtatctgaca cattaatata ttgacatcaa ataggcagac    12060

attctacttt tgcctggcaa ataaatctgc tacggagaca tcatttcctc actgtctcaa    12120

agccataact acctgggagt ctttcaacac agacccctcc gatgggaaat gctgtttatt    12180

actgaatgca ggatgctcac gctctgatct tttctccctt gtgcctttac cccagtcatt    12240

tttacttagc aacaccaatt ctagatactt ctgttctgaa gtagaaccac ccccttgcca    12300

cactgccagt tttcctgcta aaagcagtgg acagaagaca gatcatggtc accctcacaa    12360

acatggcaca cagctgtctc ggtagctgca ttcccagcat gtcctggtct aaatatctag    12420

agttgcctat gacacgttca aaggttccca agcacagtac attgggaggc ttttgctgct    12480

gtggccgttg ttttcgttta ggccaactta cttccgtatt cacatactct tggctttacg    12540

aaatacactc ctccagtcta ctaggccaat caatatattt aaaagtctga ttgccacata    12600

agtctctctc tctctctttt tgttttttgt ttgtttgttt ttttctgttt tggctgccgg    12660

tagttaaaga ctgagatagg ttggaagact aaaatacagg agtacatgag tgacaacctt    12720

cagccgtctg atttccatgc cggtaaaaca cacaaccaag ctcttcttag cgctgctaat    12780

ataaacattc actaagaggg aataggaagt gagatttacc agcttcactt tgctgatttg    12840

caaggttccc cactacgatt cactgtcatt tgatttttga aaaataattt tgtccgtctc    12900

tttgaagaaa tgtcttagtt cttttatttt gtttgtttgg ttttttttag agaagtttta    12960

tctgcagtga taggctacaa tttttatctc cgctgattat ttgtcaggat gctgaatgaa    13020

taatttggtc ctgtgccttc cttgttgttc tgaggaaaat aagagaaact tggaagtttg    13080

tttcactctt agcccatcct aaatctaaaa gaagatgtcc caggtccagg caggccatgt    13140

agtagttata aaggaggtgg tccaggtcca gccacctcaa tcaggatttg tttgttttga    13200

agcatttgct taaaagcgga gcaagagtct taacccaact tgccataaca ctgcttttct    13260

cgcttttgat gtaaatcttc aaaattcaga catcaaacag ccccagaaaa ggggaattct    13320

ctccaggcat tgctccgccc cagctcctga acaaacccag ctctgtctag catttttttc    13380

cctagcgggg gtaggggaca gggtgagaga atttcagtct cccaggctgt ctcatgattg    13440

ttagggcata aagaaacaca gtcctgccac aaattgggag catctttacc ctttagagag    13500

aaacaaaaca aaactaaaca aacaaatcaa attgctttgc atgaaggcgt agcaaataaa    13560

atctcgggct ccctgttccc tgcaccattt gtaggaggtg agaaatgagg gaaacaagag    13620

aaaggggaac tttaaaagcg ggaggcccag aaataatccc tgttaccagt ctgaatttca    13680

cttgctccgt ggctaacgtc agacctagtg tgcatgtatg ccagaagtaa actaggctcg    13740

gctgtccatt tctttaaaat atgttcacat gtttcctttt tgaaaacaat tttggggact    13800

aaacccaaat ggagagattt gaggaaatcg ttaatgtctt aacatttgag tatatttata    13860

aatgtatcag tctgtgat                                                  13878


<210>  14
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  INB-1-11-8 (H1) Heavy Chain


<220>
<221>  misc_feature
<222>  (1)..(396)
<223>  Variable Heavy Chain

<220>
<221>  misc_feature
<222>  (397)..(402)
<223>  Start of constant region

<220>
<221>  misc_feature
<222>  (949)..(1248)
<223>  Variant

<400>  14
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag       60

tcgctggagg agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc      120

acagcctctg gattctccct caataactat ccaatgacct gggtccgcca ggctccaggg      180

aaggggctgg attatatcgg agtcattaat aatagtggtg aaacagccta cgcgacctgg      240

gcgaagcgcc gattcaccat ctccagaacc tcgaccacgt tgtatctgaa aatcgccagt      300

ccgacaatcg aggacacggc cacctatttc tgtgccagag ggggtcctgt tagtagtgat      360

atgtggggcc caggcaccct ggtcatcgtc tcctcagggc aacctaaggc tccatcagtc      420

ttcccactgg ccccctgctg cggggacaca cccagctcca cggtgaccct gggctgcctg      480

gtcaaagggt acctcccgga gccagtgacc gtgacctgga actcgggcac cctcaccaat      540

ggggtacgca ccttcccgtc cgtccggcag tcctcaggcc tctactcgct gagcagcgtg      600

gtgagcgtga cctcaagcag ccagcccgtc acctgcaacg tggcccaccc agccaccaac      660

accaaagtgg acaagaccgt tgcgccctcg acatgcagca agcccacgtg cccaccccct      720

gaactcctgg ggggaccgtc tgtcttcatc ttccccccaa aacccaagga caccctcatg      780

atctcacgca cccccgaggt cacatgcgtg gtggtggacg tgagccagga tgaccccgag      840

gtgcagttca catggtacat aaacaacgag caggtgcgca ccgcccggcc gccgctacgg      900

gagcagcagt tcaacagcac gatccgcgtg gtcagcaccc tccccatcgc gcaccaggac      960

tggctgaggg gcaaggagtt caagtgcaaa gtccacaaca aggcactccc ggcccccatc     1020

gagaaaacca tctccaaagc cagagggcag cccctggagc cgaaggtcta caccatgggc     1080

cctccccggg aggagctgag cagcaggtcg gtcagcctga cctgcatgat caacggcttc     1140

tacccttccg acatctcggt ggagtgggag aagaacggga aggcagagga caactacaag     1200

accacgccgg ccgtgctgga cagcgacggc tcctacttcc tctacagcaa gctctcagtg     1260

cccacgagtg agtggcagcg gggcgacgtc ttcacctgct ccgtgatgca cgaggccttg     1320

cacaaccact acacgcagaa gtccatctcc cgctctccgg gtaaatga                  1368


<210>  15
<211>  396
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  INB-1-11-8 (H1) Variable Heavy Chain

<400>  15
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag       60

tcgctggagg agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc      120

acagcctctg gattctccct caataactat ccaatgacct gggtccgcca ggctccaggg      180

aaggggctgg attatatcgg agtcattaat aatagtggtg aaacagccta cgcgacctgg      240

gcgaagcgcc gattcaccat ctccagaacc tcgaccacgt tgtatctgaa aatcgccagt      300

ccgacaatcg aggacacggc cacctatttc tgtgccagag ggggtcctgt tagtagtgat      360

atgtggggcc caggcaccct ggtcatcgtc tcctca                                396


<210>  16
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INB-1-11-8 (H1) Heavy Chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(132)
<223>  Variable Heavy Chain

<220>
<221>  MISC_FEATURE
<222>  (133)..(138)
<223>  Start of constant region

<220>
<221>  MISC_FEATURE
<222>  (317)..(416)
<223>  Variant

<400>  16

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Asn 
        35                  40                  45              


Asn Tyr Pro Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp 
    50                  55                  60                  


Tyr Ile Gly Val Ile Asn Asn Ser Gly Glu Thr Ala Tyr Ala Thr Trp 
65                  70                  75                  80  


Ala Lys Arg Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Leu Tyr Leu 
                85                  90                  95      


Lys Ile Ala Ser Pro Thr Ile Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
            100                 105                 110         


Arg Gly Gly Pro Val Ser Ser Asp Met Trp Gly Pro Gly Thr Leu Val 
        115                 120                 125             


Ile Val Ser Ser Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly 
                165                 170                 175     


Thr Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln 
        195                 200                 205             


Pro Val Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys Val Asp 
    210                 215                 220                 


Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Gln Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn 
        275                 280                 285             


Asn Glu Gln Val Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe 
    290                 295                 300                 


Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Ala His Gln Asp 
305                 310                 315                 320 


Trp Leu Arg Gly Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu 
            340                 345                 350         


Glu Pro Lys Val Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser 
        355                 360                 365             


Arg Ser Val Ser Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ser Val Glu Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Ser Val Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Ile Ser Arg Ser Pro Gly Lys 
    450                 455 


<210>  17
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INB-1-11-8 (H1) Variable Heavy Chain

<400>  17

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Asn 
        35                  40                  45              


Asn Tyr Pro Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp 
    50                  55                  60                  


Tyr Ile Gly Val Ile Asn Asn Ser Gly Glu Thr Ala Tyr Ala Thr Trp 
65                  70                  75                  80  


Ala Lys Arg Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Leu Tyr Leu 
                85                  90                  95      


Lys Ile Ala Ser Pro Thr Ile Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
            100                 105                 110         


Arg Gly Gly Pro Val Ser Ser Asp Met Trp Gly Pro Gly Thr Leu Val 
        115                 120                 125             


Ile Val Ser Ser 
    130         


<210>  18
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  INB-1-11-8 (L4) Light chain


<220>
<221>  misc_feature
<222>  (1)..(399)
<223>  Variable Light Chain

<220>
<221>  misc_feature
<222>  (400)..(401)
<223>  Start of constant region

<220>
<221>  misc_feature
<222>  (436)..(447)
<223>  Variant

<400>  18
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc       60

acatttgccc aagtgctgac ccagactgca tcccctgtgt ctgcagttgt gggaggcaca      120

gtcaccatca attgccagtc cagtcagagt gtttatcgtg gcgactggtt agcctggtat      180

cagcagagac cagggcagcc tcccaagctc ctgatctatg gtgcatccac tttggcatct      240

ggggtcccat cgcggttcaa aggcagtgga tctgggacac acttcactct caccatcagc      300

gacctggact gtgacgatgc tgccacttac tattgtgcag gcggttttag tggccatatt      360

tatgatttcg gcggagggac cgaggtggtg gtcaaaggtg atccagttgc acctactgtc      420

ctcatcttcc caccagctgc tgatcaggtg gcaactggaa cagtcaccat cgtgtgtgtg      480

gcgaataaat actttcccga tgtcaccgtc acctgggagg tggatggcac cacccaaaca      540

actggcatcg agaacagtaa aacaccgcag aattctgcag attgtaccta caacctcagc      600

agcactctga cactgaccag cacacagtac aacagccaca aagagtacac ctgcaaggtg      660

acccagggca cgacctcagt cgtccagagc ttcaataggg gtgactgtta g               711


<210>  19
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  INB-1-11-8 (L4) Variable Light chain

<400>  19
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc       60

acatttgccc aagtgctgac ccagactgca tcccctgtgt ctgcagttgt gggaggcaca      120

gtcaccatca attgccagtc cagtcagagt gtttatcgtg gcgactggtt agcctggtat      180

cagcagagac cagggcagcc tcccaagctc ctgatctatg gtgcatccac tttggcatct      240

ggggtcccat cgcggttcaa aggcagtgga tctgggacac acttcactct caccatcagc      300

gacctggact gtgacgatgc tgccacttac tattgtgcag gcggttttag tggccatatt      360

tatgatttcg gcggagggac cgaggtggtg gtcaaaggt                             399


<210>  20
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INB-1-11-8 (L4) Light chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(133)
<223>  Variable Light Chain

<220>
<221>  MISC_FEATURE
<222>  (134)..(139)
<223>  Start of constant region

<220>
<221>  MISC_FEATURE
<222>  (146)..(149)
<223>  Variant

<400>  20

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Ala Ser Pro 
            20                  25                  30          


Val Ser Ala Val Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Val Tyr Arg Gly Asp Trp Leu Ala Trp Tyr Gln Gln Arg Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr His Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Asp Leu Asp Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Ala Gly Gly Phe Ser Gly His Ile Tyr Asp Phe Gly Gly Gly Thr Glu 
        115                 120                 125             


Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro 
    130                 135                 140                 


Pro Ala Ala Asp Gln Val Ala Thr Gly Thr Val Thr Ile Val Cys Val 
145                 150                 155                 160 


Ala Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly 
                165                 170                 175     


Thr Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser 
            180                 185                 190         


Ala Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr 
        195                 200                 205             


Gln Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr 
    210                 215                 220                 


Thr Ser Val Val Gln Ser Phe Asn Arg Gly Asp Cys 
225                 230                 235     


<210>  21
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INB-1-11-8 (L4) Variable Light chain

<400>  21

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Ala Ser Pro 
            20                  25                  30          


Val Ser Ala Val Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Val Tyr Arg Gly Asp Trp Leu Ala Trp Tyr Gln Gln Arg Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr His Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Asp Leu Asp Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Ala Gly Gly Phe Ser Gly His Ile Tyr Asp Phe Gly Gly Gly Thr Glu 
        115                 120                 125             


Val Val Val Lys Gly 
    130             


<210>  22
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  22

Glu Gln Lys Ala His Leu Glu Asp Tyr Tyr Trp Met Thr Gly Tyr Pro 
1               5                   10                  15      


Gln Gln 
        


<210>  23
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VKI_2-1-(U)_L12

<400>  23

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser 
                85                  90                  95  


<210>  24
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  24

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe 
            20          


<210>  25
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 1

<400>  25

Ala Gln Val Leu Thr Gln Thr Ala Ser Pro Val Ser Ala Val Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys 
            20              


<210>  26
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  26

Gln Ser Ser Gln Ser Val Tyr Arg Gly Asp Trp Leu Ala 
1               5                   10              


<210>  27
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 2

<400>  27

Trp Tyr Gln Gln Arg Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  28

Gly Ala Ser Thr Leu Ala Ser 
1               5           


<210>  29
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 3

<400>  29

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr His Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Asp Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  30

Ala Gly Gly Phe Ser Gly His Ile Tyr Asp 
1               5                   10  


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Junction

<400>  31

Phe Gly Gly Gly Thr Glu Val Val Val Lys 
1               5                   10  


<210>  32
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Portion

<400>  32

Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro Pro Ala Ala Asp 
1               5                   10                  15      


Gln Val Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala Asn Lys Tyr 
            20                  25                  30          


Phe Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr Thr Gln Thr 
        35                  40                  45              


Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala Asp Cys Thr 
    50                  55                  60                  


Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn Ser 
65                  70                  75                  80  


His Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr Ser Val Val 
                85                  90                  95      


Gln Ser Phe Asn Arg Gly Asp Cys 
            100                 


<210>  33
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH3_1-3_3-64

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ser Ala Ile Ser Ser Asn Gly Gly Ser Thr Tyr Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Gly Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  34
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH3_1-1_3-66

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg 
    


<210>  35
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH3_1-1_3-53

<400>  35

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg 
    


<210>  36
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader

<400>  36

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  37
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 1

<400>  37

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Asn 
            20                  25                  


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  38

Asn Tyr Pro Met Thr 
1               5   


<210>  39
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 2

<400>  39

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Tyr Ile Gly 
1               5                   10                  


<210>  40
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  40

Val Ile Asn Asn Ser Gly Glu Thr Ala Tyr Ala Thr Trp Ala Lys Arg 
1               5                   10                  15      


<210>  41
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 3

<400>  41

Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Leu Tyr Leu Lys Ile Ala 
1               5                   10                  15      


Ser Pro Thr Ile Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  42

Gly Gly Pro Val Ser Ser Asp Met 
1               5               


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Junction

<400>  43

Trp Gly Pro Gly Thr Leu Val Ile Val Ser Ser 
1               5                   10      


<210>  44
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC portion

<400>  44

Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly 
1               5                   10                  15      


Asp Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Leu Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn 
        35                  40                  45              


Gly Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln Pro Val Thr Cys 
65                  70                  75                  80  


Asn Val Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala 
                85                  90                  95      


Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly 
            100                 105                 110         


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        115                 120                 125             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
    130                 135                 140                 


Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val 
145                 150                 155                 160 


Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile 
                165                 170                 175     


Arg Val Val Ser Thr Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly 
            180                 185                 190         


Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile 
        195                 200                 205             


Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val 
    210                 215                 220                 


Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser 
225                 230                 235                 240 


Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu 
                245                 250                 255     


Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala 
            260                 265                 270         


Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
        275                 280                 285             


Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met 
    290                 295                 300                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser 
305                 310                 315                 320 


Pro Gly Lys 
            


<210>  45
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of cMAF used including Aa 19-208

<400>  45

Met Glu Tyr Val Asn Asp Phe Asp Leu Met Lys Phe Glu Val Lys Lys 
1               5                   10                  15      


Glu Pro Val Glu Thr Asp Arg Ile Ile Ser Gln Cys Gly Arg Leu Ile 
            20                  25                  30          


Ala Gly Gly Ser Leu Ser Ser Thr Pro Met Ser Thr Pro Cys Ser Ser 
        35                  40                  45              


Val Pro Pro Ser Pro Ser Phe Ser Ala Pro Ser Pro Gly Ser Gly Ser 
    50                  55                  60                  


Glu Gln Lys Ala His Leu Glu Asp Tyr Tyr Trp Met Thr Gly Tyr Pro 
65                  70                  75                  80  


Gln Gln Leu Asn Pro Glu Ala Leu Gly Phe Ser Pro Glu Asp Ala Val 
                85                  90                  95      


Glu Ala Leu Ile Ser Asn Ser His Gln Leu Gln Gly Gly Phe Asp Gly 
            100                 105                 110         


Tyr Ala Arg Gly Ala Gln Gln Leu Ala Ala Ala Ala Gly Ala Gly Ala 
        115                 120                 125             


Gly Ala Ser Leu Gly Gly Ser Gly Glu Glu Met Gly Pro Ala Ala Ala 
    130                 135                 140                 


Val Val Ser Ala Val Ile Ala Ala Ala Ala Ala Gln Ser Gly Ala Gly 
145                 150                 155                 160 


Pro His Tyr His His His His His His Ala Ala Gly His His His His 
                165                 170                 175     


Pro Thr Ala Gly Ala Pro Gly Ala Ala Gly Ser Ala Ala Ala 
            180                 185                 190 


<210>  46
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VKI_2-1-(1)_L19

<400>  46

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro 
                85                  90                  95  


<210>  47
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VKI_2-1-(1)_L5

<400>  47

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro 
                85                  90                  95  


