                         SEQUENCE LISTING

<110>  RINAT NEUROSCIENCE CORP.
 
<120>  ANTI-PD-1 ANTIBODIES AND METHODS OF USE THEREOF

<130>  PC72121A

<150>  US 62/089,658
<151>  2014-12-09

<150>  US 62/242,750
<151>  2015-10-16

<150>  US 62/251,973
<151>  2015-11-06

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  2
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  2

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Trp Asp Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Phe Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Thr Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Phe Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  3
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  3

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Ser Ser Leu Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Leu Thr Gly Thr Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  4
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  4

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Ser Ser Leu Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ser Thr Gly Thr Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  5
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  5

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Ser Ser Ile Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Thr Thr Gly Thr Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  6
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  6

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Trp Pro Gly Ser Ser Leu Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Leu Thr Gly Thr Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  7
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  7

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Trp Asp Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Phe Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Thr Ser Tyr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Phe Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  8
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  8

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Trp Asp Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Phe Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Thr Ser Tyr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Phe Tyr Pro His Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  9
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  9

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Trp Asp Ser 
            20                  25                  30          


Thr Asn Gln Lys Asn Phe Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Thr Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Phe Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  10

Lys Ser Ser Gln Ser Leu Trp Asp Ser Gly Asn Gln Lys Asn Phe Leu 
1               5                   10                  15      


Thr 
    


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  11

Trp Thr Ser Thr Arg Glu Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  12

Gln Asn Asp Tyr Phe Tyr Pro Leu Thr 
1               5                   


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  13

Gly Tyr Thr Phe Thr Ser Tyr Trp Ile Asn 
1               5                   10  


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  14

Gly Tyr Thr Phe Thr Ser Tyr 
1               5           


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  15

Ser Tyr Trp Ile Asn 
1               5   


<210>  16
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  16

Tyr Pro Gly Ser Ser Leu 
1               5       


<210>  17
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  17

Asn Ile Tyr Pro Gly Ser Ser Leu Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  18

Leu Leu Thr Gly Thr Phe Ala Tyr 
1               5               


<210>  19
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  19

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  20

Trp Thr Ser Tyr Arg Glu Ser 
1               5           


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  21

Gln Asn Asp Tyr Phe Tyr Pro His Thr 
1               5                   


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  22

Lys Ser Ser Gln Ser Leu Trp Asp Ser Thr Asn Gln Lys Asn Phe Leu 
1               5                   10                  15      


Thr 
    


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  23

Leu Ser Thr Gly Thr Phe Ala Tyr 
1               5               


<210>  24
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  24

Tyr Pro Gly Ser Ser Ile 
1               5       


<210>  25
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  25

Asn Ile Tyr Pro Gly Ser Ser Ile Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  26

Leu Thr Thr Gly Thr Phe Ala Tyr 
1               5               


<210>  27
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  27

Trp Pro Gly Ser Ser Leu 
1               5       


<210>  28
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  28

Asn Ile Trp Pro Gly Ser Ser Leu Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  29
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Ser Ser Leu Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ser Thr Gly Thr Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 


<210>  30
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  30

Lys Ser Ser Gln Ser Leu Leu Asp Ser Gly Asn Gln Lys Asn Phe Leu 
1               5                   10                  15      


Thr 
    


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  31

Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  32
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence


<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is Trp or Leu

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa is Gly or Thr

<400>  32

Lys Ser Ser Gln Ser Leu Xaa Asp Ser Xaa Asn Gln Lys Asn Phe Leu 
1               5                   10                  15      


Thr 
    


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is Thr or Tyr

<400>  33

Trp Thr Ser Xaa Arg Glu Ser 
1               5           


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa is Phe or Ser

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is Leu or His

<400>  34

Gln Asn Asp Tyr Xaa Tyr Pro Xaa Thr 
1               5                   


<210>  35
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  35

Asn Ile Tyr Pro Gly Ser Ser Ser Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  36
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Tyr or Trp

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is Leu, Ile, or Ser

<400>  36

Asn Ile Xaa Pro Gly Ser Ser Xaa Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is Leu or Ser

<400>  37

Leu Xaa Thr Gly Thr Phe Ala Tyr 
1               5               


<210>  38
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  38

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Ser Ser Leu Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ser Thr Gly Thr Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440             


<210>  39
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  39

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Trp Asp Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Phe Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Thr Ser Tyr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Phe Tyr Pro His Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Gly Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
        115                 120                 125             


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
    130                 135                 140                 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
145                 150                 155                 160 


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
                165                 170                 175     


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
            180                 185                 190         


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
        195                 200                 205             


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220     


<210>  40
<211>  351
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mAb7 heavy chain variable region DNA sequence

<400>  40
caggtgcagc tggtgcagag cggcgccgaa gtgaagaaac caggagccag cgtgaaagtg       60

agttgtaagg catccggcta tacctttacc tcttactgga tcaattgggt gaggcaggca      120

cctggccagg gcctggaatg gatgggaaat atctatcccg gctctagctt gactaactac      180

aatgaaaagt ttaagaatcg cgtgaccatg acccgggaca ctagcacctc caccgtgtac      240

atggagctgt cctccctgcg gagcgaggac accgccgtct actattgtgc ccgcctgagt      300

accgggacct ttgcctactg gggacagggt acactggtca ccgtctcctc a               351


<210>  41
<211>  339
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mAb7 light chain variable region DNA sequence

<400>  41
gacatcgtga tgactcagtc tcccgatagc ctggcagtca gcctgggaga gcgggccacc       60

ataaactgca aaagctcgca gtcgctgtgg gacagtggta atcagaagaa tttcctgacc      120

tggtaccagc agaagcctgg ccagccaccc aagctgctga tctactggac ctcatatcgg      180

gagtccgggg tgcccgacag attctctgga agtggcagcg gtacggactt cacactgacc      240

atatccagtc tgcaagctga ggacgtggct gtttattact gccagaacga ctacttttat      300

cctcacactt tcggaggcgg taccaaggtc gagatcaaa                             339


<210>  42
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 
1               5                   10                  15      


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
            20                  25                  30          


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 
        35                  40                  45              


Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile 
65                  70                  75                  80  


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 
            100                 105                 110         


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 


Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
145                 150                 155                 160 


Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                165                 170                 175     


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
            180                 185                 190         


Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
        195                 200                 205             


Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 
    210                 215                 220                 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 


Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                245                 250                 255     


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         


Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 
        275                 280                 285             


Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
    290                 295                 300                 


Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg 
305                 310                 315                 320 


Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                325                 330                 335     


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val 
            340                 345                 350         


Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
        355                 360                 365             


Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
    370                 375                 380                 


Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
385                 390                 395                 400 


Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                405                 410                 415     


Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
            420                 425                 430         


Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
        435                 440                 445             


Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
    450                 455                 460                 


Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu 
465                 470                 475                 480 


Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
                485                 490                 495     


Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
            500                 505                 510         


Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
        515                 520                 525             


Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
    530                 535                 540                 


Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
545                 550                 555                 560 


Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 
                565                 570                 575     


Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 
            580                 585                 590         


Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
        595                 600                 605             


Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 
    610                 615                 620                 


Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
625                 630                 635                 640 


Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser 
                645                 650                 655     


Asn Pro Ile Val Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu 
            660                 665                 670         


Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg 
        675                 680                 685             


His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser 
    690                 695                 700                 


Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp 
705                 710                 715                 720 


Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala Ala 
                725                 730                 735     


Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
            740                 745                 750 


<210>  43
<211>  2217
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  43
atggctagcg ccagacgccc cagatggctg tgtgctggcg ctctggtgct ggctggcggc       60

ttcttcctgc tgggcttcct gttcggctgg ttcatcaagt cctccaacga ggccaccaac      120

atcaccccca agcacaacat gaaggccttt ctggacgagc tgaaggccga gaatatcaag      180

aagttcctgt acaacttcac ccagatcccc cacctggccg gcaccgagca gaacttccag      240

ctggccaagc agatccagtc ccagtggaaa gagttcggcc tggactccgt ggaactggcc      300

cactacgacg tgctgctgtc ctaccccaac aagacccacc ccaactacat ctccatcatc      360

aacgaggacg gcaacgaaat cttcaacacc tccctgttcg agcccccacc cccaggctac      420

gagaacgtgt ccgacatcgt gcccccattc tccgccttca gtccacaagg catgcccgag      480

ggcgacctgg tgtacgtgaa ctacgccagg accgaggact tcttcaagct ggaacgcgac      540

atgaagatca actgctccgg caagatcgtg atcgccagat acggcaaggt gttcaggggc      600

aacaaagtga agaacgccca gctggctggg gccaagggcg tgatcctgta ctccgacccc      660

gccgactact tcgccccagg cgtgaagtcc taccccgacg gatggaacct gccaggcggc      720

ggagtgcaga ggggcaacat cctgaacctg aacggcgctg gcgaccccct gaccccagga      780

tacccagcca acgagtacgc ctacagaaga ggaatcgccg aggccgtggg cctgccctct      840

atcccagtgc accccatcgg ctactacgac gcccagaaac tgctggaaaa gatgggcggc      900

tccgccccac ccgactcctc ttggagaggc tccctgaagg tgccctacaa cgtgggccca      960

ggcttcaccg gcaacttctc cacccagaaa gtgaagatgc acatccactc caccaacgaa     1020

gtgaccagga tctacaacgt gatcggcacc ctgagaggcg ccgtggaacc cgacagatac     1080

gtgatcctgg gcggccacag ggacagctgg gtgttcggcg gcatcgaccc acagtctggc     1140

gccgctgtgg tgcacgagat cgtgcggtcc ttcggaaccc tgaagaaaga gggatggcgc     1200

cccagaagga ccatcctgtt cgccagctgg gacgccgagg aattcggcct gctgggatcc     1260

accgagtggg ccgaggaaaa ctccaggctg ctgcaggaac gcggcgtcgc ctacatcaac     1320

gccgactcct ccatcgaggg caactacacc ctgagggtgg actgcacccc cctgatgtac     1380

tccctggtgc acaacctgac caaagagctg aagtcccccg acgagggctt cgagggcaag     1440

tccctgtacg agtcctggac caagaagtcc ccatcccccg agttctccgg catgcccagg     1500

atctccaagc tgggctccgg caacgacttc gaggtgttct tccagaggct gggaatcgcc     1560

tccggcaggg ccagatacac caagaactgg gagacaaaca agttctccgg ataccccctg     1620

taccactccg tgtacgaaac ctacgagctg gtggaaaagt tctacgaccc catgttcaag     1680

taccacctga ccgtggccca agtccgcgga ggcatggtgt tcgagctggc caactccatc     1740

gtgctgccct tcgactgcag agactacgcc gtggtgctga ggaagtacgc cgacaaaatc     1800

tactccatct ccatgaagca cccccaggaa atgaagacct actccgtgtc cttcgactcc     1860

ctgttctccg ccgtgaagaa tttcaccgag atcgcctcca agttcagcga gaggctgcag     1920

gacttcgaca agtccaaccc aatcgtgctg aggatgatga acgaccagct gatgttcctg     1980

gaaagggcct tcatcgaccc cctgggcctg ccagacagac ccttctacag gcacgtgatc     2040

tacgccccat cctcccacaa caaatacgcc ggcgagtcct tccccggcat ctacgatgcc     2100

ctgttcgaca tcgagtccaa ggtggacccc tccaaggcct ggggcgaagt gaagaggcaa     2160

atctacgtgg ccgccttcac agtgcaagcc gctgccgaaa ccctgtccga ggtggcc        2217


<210>  44
<211>  33562
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44
ccatcttcaa taatatacct caaacttttt gtgcgcgtta atatgcaaat gaggcgtttg       60

aatttgggga ggaagggcgg tgattggtcg agggatgagc gaccgttagg ggcggggcga      120

gtgacgtttt gatgacgtgg ttgcgaggag gagccagttt gcaagttctc gtgggaaaag      180

tgacgtcaaa cgaggtgtgg tttgaacacg gaaatactca attttcccgc gctctctgac      240

aggaaatgag gtgtttctgg gcggatgcaa gtgaaaacgg gccattttcg cgcgaaaact      300

gaatgaggaa gtgaaaatct gagtaatttc gcgtttatgg cagggaggag tatttgccga      360

gggccgagta gactttgacc gattacgtgg gggtttcgat taccgtgttt ttcacctaaa      420

tttccgcgta cggtgtcaaa gtccggtgtt tttactactg taatagtaat caattacggg      480

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      540

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      600

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      660

ccacttggca gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga      720

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg      780

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacat      840

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      900

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactc      960

cgccccattg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc     1020

tgtccctatc agtgatagag atctccctat cagtgataga gagtttagtg aaccgtcaga     1080

tccgctaggg taccgcgatc accatggcta gcgccagacg ccccagatgg ctgtgtgctg     1140

gcgctctggt gctggctggc ggcttcttcc tgctgggctt cctgttcggc tggttcatca     1200

agtcctccaa cgaggccacc aacatcaccc ccaagcacaa catgaaggcc tttctggacg     1260

agctgaaggc cgagaatatc aagaagttcc tgtacaactt cacccagatc ccccacctgg     1320

ccggcaccga gcagaacttc cagctggcca agcagatcca gtcccagtgg aaagagttcg     1380

gcctggactc cgtggaactg gcccactacg acgtgctgct gtcctacccc aacaagaccc     1440

accccaacta catctccatc atcaacgagg acggcaacga aatcttcaac acctccctgt     1500

tcgagccccc acccccaggc tacgagaacg tgtccgacat cgtgccccca ttctccgcct     1560

tcagtccaca aggcatgccc gagggcgacc tggtgtacgt gaactacgcc aggaccgagg     1620

acttcttcaa gctggaacgc gacatgaaga tcaactgctc cggcaagatc gtgatcgcca     1680

gatacggcaa ggtgttcagg ggcaacaaag tgaagaacgc ccagctggct ggggccaagg     1740

gcgtgatcct gtactccgac cccgccgact acttcgcccc aggcgtgaag tcctaccccg     1800

acggatggaa cctgccaggc ggcggagtgc agaggggcaa catcctgaac ctgaacggcg     1860

ctggcgaccc cctgacccca ggatacccag ccaacgagta cgcctacaga agaggaatcg     1920

ccgaggccgt gggcctgccc tctatcccag tgcaccccat cggctactac gacgcccaga     1980

aactgctgga aaagatgggc ggctccgccc cacccgactc ctcttggaga ggctccctga     2040

aggtgcccta caacgtgggc ccaggcttca ccggcaactt ctccacccag aaagtgaaga     2100

tgcacatcca ctccaccaac gaagtgacca ggatctacaa cgtgatcggc accctgagag     2160

gcgccgtgga acccgacaga tacgtgatcc tgggcggcca cagggacagc tgggtgttcg     2220

gcggcatcga cccacagtct ggcgccgctg tggtgcacga gatcgtgcgg tccttcggaa     2280

ccctgaagaa agagggatgg cgccccagaa ggaccatcct gttcgccagc tgggacgccg     2340

aggaattcgg cctgctggga tccaccgagt gggccgagga aaactccagg ctgctgcagg     2400

aacgcggcgt cgcctacatc aacgccgact cctccatcga gggcaactac accctgaggg     2460

tggactgcac ccccctgatg tactccctgg tgcacaacct gaccaaagag ctgaagtccc     2520

ccgacgaggg cttcgagggc aagtccctgt acgagtcctg gaccaagaag tccccatccc     2580

ccgagttctc cggcatgccc aggatctcca agctgggctc cggcaacgac ttcgaggtgt     2640

tcttccagag gctgggaatc gcctccggca gggccagata caccaagaac tgggagacaa     2700

acaagttctc cggatacccc ctgtaccact ccgtgtacga aacctacgag ctggtggaaa     2760

agttctacga ccccatgttc aagtaccacc tgaccgtggc ccaagtccgc ggaggcatgg     2820

tgttcgagct ggccaactcc atcgtgctgc ccttcgactg cagagactac gccgtggtgc     2880

tgaggaagta cgccgacaaa atctactcca tctccatgaa gcacccccag gaaatgaaga     2940

cctactccgt gtccttcgac tccctgttct ccgccgtgaa gaatttcacc gagatcgcct     3000

ccaagttcag cgagaggctg caggacttcg acaagtccaa cccaatcgtg ctgaggatga     3060

tgaacgacca gctgatgttc ctggaaaggg ccttcatcga ccccctgggc ctgccagaca     3120

gacccttcta caggcacgtg atctacgccc catcctccca caacaaatac gccggcgagt     3180

ccttccccgg catctacgat gccctgttcg acatcgagtc caaggtggac ccctccaagg     3240

cctggggcga agtgaagagg caaatctacg tggccgcctt cacagtgcaa gccgctgccg     3300

aaaccctgtc cgaggtggcc tgaatcgcac ctcgagattt aaatctgatc ataatcagcc     3360

ataccacatt tgtagaggtt ttacttgctt taaaaaacct cccacacctc cccctgaacc     3420

tgaaacataa aatgaatgca attgttgttg ttaacttgtt tattgcagct tataatggtt     3480

acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta     3540

gttgtggttt gtccaaactc atcaatgtat cttatatgct ggccaccgta catgtggctt     3600

cccatgctcg caagccctgg cccgagttcg agcacaatgt catgaccagg tgcaatatgc     3660

atctggggtc ccgccgaggc atgttcatgc cctaccagtg caacctgaat tatgtgaagg     3720

tgctgctgga gcccgatgcc atgtccagag tgagcctgac gggggtgttt gacatgaatg     3780

tggaggtgtg gaagattctg agatatgatg aatccaagac caggtgccga gcctgcgagt     3840

gcggagggaa gcatgccagg ttccagcccg tgtgtgtgga tgtgacggag gacctgcgac     3900

ccgatcattt ggtgttgccc tgcaccggga cggagttcgg ttccagcggg gaagaatctg     3960

actagagtga gtagtgttct ggggcggggg aggacctgca tgagggccag aataactgaa     4020

atctgtgctt ttctgtgtgt tgcagcagca tgagcggaag cggctccttt gagggagggg     4080

tattcagccc ttatctgacg gggcgtctcc cctcctgggc gggagtgcgt cagaatgtga     4140

tgggatccac ggtggacggc cggcccgtgc agcccgcgaa ctcttcaacc ctgacctatg     4200

caaccctgag ctcttcgtcg ttggacgcag ctgccgccgc agctgctgca tctgccgcca     4260

gcgccgtgcg cggaatggcc atgggcgccg gctactacgg cactctggtg gccaactcga     4320

gttccaccaa taatcccgcc agcctgaacg aggagaagct gttgctgctg atggcccagc     4380

tcgaggcctt gacccagcgc ctgggcgagc tgacccagca ggtggctcag ctgcaggagc     4440

agacgcgggc cgcggttgcc acggtgaaat ccaaataaaa aatgaatcaa taaataaacg     4500

gagacggttg ttgattttaa cacagagtct gaatctttat ttgatttttc gcgcgcggta     4560

ggccctggac caccggtctc gatcattgag cacccggtgg atcttttcca ggacccggta     4620

gaggtgggct tggatgttga ggtacatggg catgagcccg tcccgggggt ggaggtagct     4680

ccattgcagg gcctcgtgct cgggggtggt gttgtaaatc acccagtcat agcaggggcg     4740

cagggcatgg tgttgcacaa tatctttgag gaggagactg atggccacgg gcagcccttt     4800

ggtgtaggtg tttacaaatc tgttgagctg ggagggatgc atgcgggggg agatgaggtg     4860

catcttggcc tggatcttga gattggcgat gttaccgccc agatcccgcc tggggttcat     4920

gttgtgcagg accaccagca cggtgtatcc ggtgcacttg gggaatttat catgcaactt     4980

ggaagggaag gcgtgaaaga atttggcgac gcctttgtgc ccgcccaggt tttccatgca     5040

ctcatccatg atgatggcga tgggcccgtg ggcggcggcc tgggcaaaga cgtttcgggg     5100

gtcggacaca tcatagttgt ggtcctgggt gaggtcatca taggccattt taatgaattt     5160

ggggcggagg gtgccggact gggggacaaa ggtaccctcg atcccggggg cgtagttccc     5220

ctcacagatc tgcatctccc aggctttgag ctcggagggg gggatcatgt ccacctgcgg     5280

ggcgataaag aacacggttt ccggggcggg ggagatgagc tgggccgaaa gcaagttccg     5340

gagcagctgg gacttgccgc agccggtggg gccgtagatg accccgatga ccggctgcag     5400

gtggtagttg agggagagac agctgccgtc ctcccggagg aggggggcca cctcgttcat     5460

catctcgcgc acgtgcatgt tctcgcgcac cagttccgcc aggaggcgct ctccccccag     5520

ggataggagc tcctggagcg aggcgaagtt tttcagcggc ttgagtccgt cggccatggg     5580

cattttggag agggtttgtt gcaagagttc caggcggtcc cagagctcgg tgatgtgctc     5640

tacggcatct cgatccagca gacctcctcg tttcgcgggt tgggacggct gcgggagtag     5700

ggcaccagac gatgggcgtc cagcgcagcc agggtccggt ccttccaggg tcgcagcgtc     5760

cgcgtcaggg tggtctccgt cacggtgaag gggtgcgcgc cgggctgggc gcttgcgagg     5820

gtgcgcttca ggctcatccg gctggtcgaa aaccgctccc gatcggcgcc ctgcgcgtcg     5880

gccaggtagc aattgaccat gagttcgtag ttgagcgcct cggccgcgtg gcctttggcg     5940

cggagcttac ctttggaagt ctgcccgcag gcgggacaga ggagggactt gagggcgtag     6000

agcttggggg cgaggaagac ggactcgggg gcgtaggcgt ccgcgccgca gtgggcgcag     6060

acggtctcgc actccacgag ccaggtgagg tcgggctggt cggggtcaaa aaccagtttc     6120

ccgccgttct ttttgatgcg tttcttacct ttggtctcca tgagctcgtg tccccgctgg     6180

gtgacaaaga ggctgtccgt gtccccgtag accgacttta tgggccggtc ctcgagcggt     6240

gtgccgcggt cctcctcgta gaggaacccc gcccactccg agacgaaagc ccgggtccag     6300

gccagcacga aggaggccac gtgggacggg tagcggtcgt tgtccaccag cgggtccacc     6360

ttttccaggg tatgcaaaca catgtccccc tcgtccacat ccaggaaggt gattggcttg     6420

taagtgtagg ccacgtgacc gggggtcccg gccggggggg tataaaaggg tgcgggtccc     6480

tgctcgtcct cactgtcttc cggatcgctg tccaggagcg ccagctgttg gggtaggtat     6540

tccctctcga aggcgggcat gacctcggca ctcaggttgt cagtttctag aaacgaggag     6600

gatttgatat tgacggtgcc ggcggagatg cctttcaaga gcccctcgtc catctggtca     6660

gaaaagacga tctttttgtt gtcgagcttg gtggcgaagg agccgtagag ggcgttggag     6720

aggagcttgg cgatggagcg catggtctgg tttttttcct tgtcggcgcg ctccttggcg     6780

gcgatgttga gctgcacgta ctcgcgcgcc acgcacttcc attcggggaa gacggtggtc     6840

agctcgtcgg gcacgattct gacctgccag ccccgattat gcagggtgat gaggtccaca     6900

ctggtggcca cctcgccgcg caggggctca ttagtccagc agaggcgtcc gcccttgcgc     6960

gagcagaagg ggggcagggg gtccagcatg acctcgtcgg gggggtcggc atcgatggtg     7020

aagatgccgg gcaggaggtc ggggtcaaag tagctgatgg aagtggccag atcgtccagg     7080

gcagcttgcc attcgcgcac ggccagcgcg cgctcgtagg gactgagggg cgtgccccag     7140

ggcatgggat gggtaagcgc ggaggcgtac atgccgcaga tgtcgtagac gtagaggggc     7200

tcctcgagga tgccgatgta ggtggggtag cagcgccccc cgcggatgct ggcgcgcacg     7260

tagtcataca gctcgtgcga gggggcgagg agccccgggc ccaggttggt gcgactgggc     7320

ttttcggcgc ggtagacgat ctggcggaaa atggcatgcg agttggagga gatggtgggc     7380

ctttggaaga tgttgaagtg ggcgtggggc agtccgaccg agtcgcggat gaagtgggcg     7440

taggagtctt gcagcttggc gacgagctcg gcggtgacta ggacgtccag agcgcagtag     7500

tcgagggtct cctggatgat gtcatacttg agctgtccct tttgtttcca cagctcgcgg     7560

ttgagaagga actcttcgcg gtccttccag tactcttcga gggggaaccc gtcctgatct     7620

gcacggtaag agcctagcat gtagaactgg ttgacggcct tgtaggcgca gcagcccttc     7680

tccacgggga gggcgtaggc ctgggcggcc ttgcgcaggg aggtgtgcgt gagggcgaaa     7740

gtgtccctga ccatgacctt gaggaactgg tgcttgaagt cgatatcgtc gcagcccccc     7800

tgctcccaga gctggaagtc cgtgcgcttc ttgtaggcgg ggttgggcaa agcgaaagta     7860

acatcgttga agaggatctt gcccgcgcgg ggcataaagt tgcgagtgat gcggaaaggt     7920

tggggcacct cggcccggtt gttgatgacc tgggcggcga gcacgatctc gtcgaagccg     7980

ttgatgttgt ggcccacgat gtagagttcc acgaatcgcg gacggccctt gacgtggggc     8040

agtttcttga gctcctcgta ggtgagctcg tcggggtcgc tgagcccgtg ctgctcgagc     8100

gcccagtcgg cgagatgggg gttggcgcgg aggaaggaag tccagagatc cacggccagg     8160

gcggtttgca gacggtcccg gtactgacgg aactgctgcc cgacggccat tttttcgggg     8220

gtgacgcagt agaaggtgcg ggggtccccg tgccagcgat cccatttgag ctggagggcg     8280

agatcgaggg cgagctcgac gagccggtcg tccccggaga gtttcatgac cagcatgaag     8340

gggacgagct gcttgccgaa ggaccccatc caggtgtagg tttccacatc gtaggtgagg     8400

aagagccttt cggtgcgagg atgcgagccg atggggaaga actggatctc ctgccaccaa     8460

ttggaggaat ggctgttgat gtgatggaag tagaaatgcc gacggcgcgc cgaacactcg     8520

tgcttgtgtt tatacaagcg gccacagtgc tcgcaacgct gcacgggatg cacgtgctgc     8580

acgagctgta cctgagttcc tttgacgagg aatttcagtg ggaagtggag tcgtggcgcc     8640

tgcatctcgt gctgtactac gtcgtggtgg tcggcctggc cctcttctgc ctcgatggtg     8700

gtcatgctga cgagcccgcg cgggaggcag gtccagacct cggcgcgagc gggtcggaga     8760

gcgaggacga gggcgcgcag gccggagctg tccagggtcc tgagacgctg cggagtcagg     8820

tcagtgggca gcggcggcgc gcggttgact tgcaggagtt tttccagggc gcgcgggagg     8880

tccagatggt acttgatctc caccgcgcca ttggtggcga cgtcgatggc ttgcagggtc     8940

ccgtgcccct ggggtgtgac caccgtcccc cgtttcttct tgggcggctg gggcgacggg     9000

ggcggtgcct cttccatggt tagaagcggc ggcgaggacg cgcgccgggc ggcaggggcg     9060

gctcggggcc cggaggcagg ggcggcaggg gcacgtcggc gccgcgcgcg ggtaggttct     9120

ggtactgcgc ccggagaaga ctggcgtgag cgacgacgcg acggttgacg tcctggatct     9180

gacgcctctg ggtgaaggcc acgggacccg tgagtttgaa cctgaaagag agttcgacag     9240

aatcaatctc ggtatcgttg acggcggcct gccgcaggat ctcttgcacg tcgcccgagt     9300

tgtcctggta ggcgatctcg gtcatgaact gctcgatctc ctcctcttga aggtctccgc     9360

ggccggcgcg ctccacggtg gccgcgaggt cgttggagat gcggcccatg agctgcgaga     9420

aggcgttcat gcccgcctcg ttccagacgc ggctgtagac cacgacgccc tcgggatcgc     9480

gggcgcgcat gaccacctgg gcgaggttga gctccacgtg gcgcgtgaag accgcgtagt     9540

tgcagaggcg ctggtagagg tagttgagcg tggtggcgat gtgctcggtg acgaagaaat     9600

acatgatcca gcggcggagc ggcatctcgc tgacgtcgcc cagcgcctcc aaacgttcca     9660

tggcctcgta aaagtccacg gcgaagttga aaaactggga gttgcgcgcc gagacggtca     9720

actcctcctc cagaagacgg atgagctcgg cgatggtggc gcgcacctcg cgctcgaagg     9780

cccccgggag ttcctccact tcctcttctt cctcctccac taacatctct tctacttcct     9840

cctcaggcgg cagtggtggc gggggagggg gcctgcgtcg ccggcggcgc acgggcagac     9900

ggtcgatgaa gcgctcgatg gtctcgccgc gccggcgtcg catggtctcg gtgacggcgc     9960

gcccgtcctc gcggggccgc agcgtgaaga cgccgccgcg catctccagg tggccggggg    10020

ggtccccgtt gggcagggag agggcgctga cgatgcatct tatcaattgc cccgtaggga    10080

ctccgcgcaa ggacctgagc gtctcgagat ccacgggatc tgaaaaccgc tgaacgaagg    10140

cttcgagcca gtcgcagtcg caaggtaggc tgagcacggt ttcttctggc gggtcatgtt    10200

ggttgggagc ggggcgggcg atgctgctgg tgatgaagtt gaaataggcg gttctgagac    10260

ggcggatggt ggcgaggagc accaggtctt tgggcccggc ttgctggatg cgcagacggt    10320

cggccatgcc ccaggcgtgg tcctgacacc tggccaggtc cttgtagtag tcctgcatga    10380

gccgctccac gggcacctcc tcctcgcccg cgcggccgtg catgcgcgtg agcccgaagc    10440

cgcgctgggg ctggacgagc gccaggtcgg cgacgacgcg ctcggcgagg atggcttgct    10500

ggatctgggt gagggtggtc tggaagtcat caaagtcgac gaagcggtgg taggctccgg    10560

tgttgatggt gtaggagcag ttggccatga cggaccagtt gacggtctgg tggcccggac    10620

gcacgagctc gtggtacttg aggcgcgagt aggcgcgcgt gtcgaagatg tagtcgttgc    10680

aggtgcgcac caggtactgg tagccgatga ggaagtgcgg cggcggctgg cggtagagcg    10740

gccatcgctc ggtggcgggg gcgccgggcg cgaggtcctc gagcatggtg cggtggtagc    10800

cgtagatgta cctggacatc caggtgatgc cggcggcggt ggtggaggcg cgcgggaact    10860

cgcggacgcg gttccagatg ttgcgcagcg gcaggaagta gttcatggtg ggcacggtct    10920

ggcccgtgag gcgcgcgcag tcgtggatgc tctatacggg caaaaacgaa agcggtcagc    10980

ggctcgactc cgtggcctgg aggctaagcg aacgggttgg gctgcgcgtg taccccggtt    11040

cgaatctcga atcaggctgg agccgcagct aacgtggtat tggcactccc gtctcgaccc    11100

aagcctgcac caaccctcca ggatacggag gcgggtcgtt ttgcaacttt tttttggagg    11160

ccggatgaga ctagtaagcg cggaaagcgg ccgaccgcga tggctcgctg ccgtagtctg    11220

gagaagaatc gccagggttg cgttgcggtg tgccccggtt cgaggccggc cggattccgc    11280

ggctaacgag ggcgtggctg ccccgtcgtt tccaagaccc catagccagc cgacttctcc    11340

agttacggag cgagcccctc ttttgttttg tttgtttttg ccagatgcat cccgtactgc    11400

ggcagatgcg cccccaccac cctccaccgc aacaacagcc ccctccacag ccggcgcttc    11460

tgcccccgcc ccagcagcaa cttccagcca cgaccgccgc ggccgccgtg agcggggctg    11520

gacagagtta tgatcaccag ctggccttgg aagagggcga ggggctggcg cgcctggggg    11580

cgtcgtcgcc ggagcggcac ccgcgcgtgc agatgaaaag ggacgctcgc gaggcctacg    11640

tgcccaagca gaacctgttc agagacagga gcggcgagga gcccgaggag atgcgcgcgg    11700

cccggttcca cgcggggcgg gagctgcggc gcggcctgga ccgaaagagg gtgctgaggg    11760

acgaggattt cgaggcggac gagctgacgg ggatcagccc cgcgcgcgcg cacgtggccg    11820

cggccaacct ggtcacggcg tacgagcaga ccgtgaagga ggagagcaac ttccaaaaat    11880

ccttcaacaa ccacgtgcgc accctgatcg cgcgcgagga ggtgaccctg ggcctgatgc    11940

acctgtggga cctgctggag gccatcgtgc agaaccccac cagcaagccg ctgacggcgc    12000

agctgttcct ggtggtgcag catagtcggg acaacgaagc gttcagggag gcgctgctga    12060

atatcaccga gcccgagggc cgctggctcc tggacctggt gaacattctg cagagcatcg    12120

tggtgcagga gcgcgggctg ccgctgtccg agaagctggc ggccatcaac ttctcggtgc    12180

tgagtttggg caagtactac gctaggaaga tctacaagac cccgtacgtg cccatagaca    12240

aggaggtgaa gatcgacggg ttttacatgc gcatgaccct gaaagtgctg accctgagcg    12300

acgatctggg ggtgtaccgc aacgacagga tgcaccgtgc ggtgagcgcc agcaggcggc    12360

gcgagctgag cgaccaggag ctgatgcata gtctgcagcg ggccctgacc ggggccggga    12420

ccgaggggga gagctacttt gacatgggcg cggacctgca ctggcagccc agccgccggg    12480

ccttggaggc ggcggcagga ccctacgtag aagaggtgga cgatgaggtg gacgaggagg    12540

gcgagtacct ggaagactga tggcgcgacc gtatttttgc tagatgcaac aacaacagcc    12600

acctcctgat cccgcgatgc gggcggcgct gcagagccag ccgtccggca ttaactcctc    12660

ggacgattgg acccaggcca tgcaacgcat catggcgctg acgacccgca accccgaagc    12720

ctttagacag cagccccagg ccaaccggct ctcggccatc ctggaggccg tggtgccctc    12780

gcgctccaac cccacgcacg agaaggtcct ggccatcgtg aacgcgctgg tggagaacaa    12840

ggccatccgc ggcgacgagg ccggcctggt gtacaacgcg ctgctggagc gcgtggcccg    12900

ctacaacagc accaacgtgc agaccaacct ggaccgcatg gtgaccgacg tgcgcgaggc    12960

cgtggcccag cgcgagcggt tccaccgcga gtccaacctg ggatccatgg tggcgctgaa    13020

cgccttcctc agcacccagc ccgccaacgt gccccggggc caggaggact acaccaactt    13080

catcagcgcc ctgcgcctga tggtgaccga ggtgccccag agcgaggtgt accagtccgg    13140

gccggactac ttcttccaga ccagtcgcca gggcttgcag accgtgaacc tgagccaggc    13200

tttcaagaac ttgcagggcc tgtggggcgt gcaggccccg gtcggggacc gcgcgacggt    13260

gtcgagcctg ctgacgccga actcgcgcct gctgctgctg ctggtggccc ccttcacgga    13320

cagcggcagc atcaaccgca actcgtacct gggctacctg attaacctgt accgcgaggc    13380

catcggccag gcgcacgtgg acgagcagac ctaccaggag atcacccacg tgagccgcgc    13440

cctgggccag gacgacccgg gcaacctgga agccaccctg aactttttgc tgaccaaccg    13500

gtcgcagaag atcccgcccc agtacgcgct cagcaccgag gaggagcgca tcctgcgtta    13560

cgtgcagcag agcgtgggcc tgttcctgat gcaggagggg gccaccccca gcgccgcgct    13620

cgacatgacc gcgcgcaaca tggagcccag catgtacgcc agcaaccgcc cgttcatcaa    13680

taaactgatg gactacttgc atcgggcggc cgccatgaac tctgactatt tcaccaacgc    13740

catcctgaat ccccactggc tcccgccgcc ggggttctac acgggcgagt acgacatgcc    13800

cgaccccaat gacgggttcc tgtgggacga tgtggacagc agcgtgttct ccccccgacc    13860

gggtgctaac gagcgcccct tgtggaagaa ggaaggcagc gaccgacgcc cgtcctcggc    13920

gctgtccggc cgcgagggtg ctgccgcggc ggtgcccgag gccgccagtc ctttcccgag    13980

cttgcccttc tcgctgaaca gtatccgcag cagcgagctg ggcaggatca cgcgcccgcg    14040

cttgctgggc gaagaggagt acttgaatga ctcgctgttg agacccgagc gggagaagaa    14100

cttccccaat aacgggatag aaagcctggt ggacaagatg agccgctgga agacgtatgc    14160

gcaggagcac agggacgatc cccgggcgtc gcagggggcc acgagccggg gcagcgccgc    14220

ccgtaaacgc cggtggcacg acaggcagcg gggacagatg tgggacgatg aggactccgc    14280

cgacgacagc agcgtgttgg acttgggtgg gagtggtaac ccgttcgctc acctgcgccc    14340

ccgtatcggg cgcatgatgt aagagaaacc gaaaataaat gatactcacc aaggccatgg    14400

cgaccagcgt gcgttcgttt cttctctgtt gttgttgtat ctagtatgat gaggcgtgcg    14460

tacccggagg gtcctcctcc ctcgtacgag agcgtgatgc agcaggcgat ggcggcggcg    14520

gcgatgcagc ccccgctgga ggctccttac gtgcccccgc ggtacctggc gcctacggag    14580

gggcggaaca gcattcgtta ctcggagctg gcacccttgt acgataccac ccggttgtac    14640

ctggtggaca acaagtcggc ggacatcgcc tcgctgaact accagaacga ccacagcaac    14700

ttcctgacca ccgtggtgca gaacaatgac ttcaccccca cggaggccag cacccagacc    14760

atcaactttg acgagcgctc gcggtggggc ggccagctga aaaccatcat gcacaccaac    14820

atgcccaacg tgaacgagtt catgtacagc aacaagttca aggcgcgggt gatggtctcc    14880

cgcaagaccc ccaatggggt gacagtgaca gaggattatg atggtagtca ggatgagctg    14940

aagtatgaat gggtggaatt tgagctgccc gaaggcaact tctcggtgac catgaccatc    15000

gacctgatga acaacgccat catcgacaat tacttggcgg tggggcggca gaacggggtg    15060

ctggagagcg acatcggcgt gaagttcgac actaggaact tcaggctggg ctgggacccc    15120

gtgaccgagc tggtcatgcc cggggtgtac accaacgagg ctttccatcc cgatattgtc    15180

ttgctgcccg gctgcggggt ggacttcacc gagagccgcc tcagcaacct gctgggcatt    15240

cgcaagaggc agcccttcca ggaaggcttc cagatcatgt acgaggatct ggaggggggc    15300

aacatccccg cgctcctgga tgtcgacgcc tatgagaaaa gcaaggagga tgcagcagct    15360

gaagcaactg cagccgtagc taccgcctct accgaggtca ggggcgataa ttttgcaagc    15420

gccgcagcag tggcagcggc cgaggcggct gaaaccgaaa gtaagatagt cattcagccg    15480

gtggagaagg atagcaagaa caggagctac aacgtactac cggacaagat aaacaccgcc    15540

taccgcagct ggtacctagc ctacaactat ggcgaccccg agaagggcgt gcgctcctgg    15600

acgctgctca ccacctcgga cgtcacctgc ggcgtggagc aagtctactg gtcgctgccc    15660

gacatgatgc aagacccggt caccttccgc tccacgcgtc aagttagcaa ctacccggtg    15720

gtgggcgccg agctcctgcc cgtctactcc aagagcttct tcaacgagca ggccgtctac    15780

tcgcagcagc tgcgcgcctt cacctcgctt acgcacgtct tcaaccgctt ccccgagaac    15840

cagatcctcg tccgcccgcc cgcgcccacc attaccaccg tcagtgaaaa cgttcctgct    15900

ctcacagatc acgggaccct gccgctgcgc agcagtatcc ggggagtcca gcgcgtgacc    15960

gttactgacg ccagacgccg cacctgcccc tacgtctaca aggccctggg catagtcgcg    16020

ccgcgcgtcc tctcgagccg caccttctaa atgtccattc tcatctcgcc cagtaataac    16080

accggttggg gcctgcgcgc gcccagcaag atgtacggag gcgctcgcca acgctccacg    16140

caacaccccg tgcgcgtgcg cgggcacttc cgcgctccct ggggcgccct caagggccgc    16200

gtgcggtcgc gcaccaccgt cgacgacgtg atcgaccagg tggtggccga cgcgcgcaac    16260

tacacccccg ccgccgcgcc cgtctccacc gtggacgccg tcatcgacag cgtggtggcc    16320

gacgcgcgcc ggtacgcccg cgccaagagc cggcggcggc gcatcgcccg gcggcaccgg    16380

agcacccccg ccatgcgcgc ggcgcgagcc ttgctgcgca gggccaggcg cacgggacgc    16440

agggccatgc tcagggcggc cagacgcgcg gcttcaggcg ccagcgccgg caggacccgg    16500

agacgcgcgg ccacggcggc ggcagcggcc atcgccagca tgtcccgccc gcggcgaggg    16560

aacgtgtact gggtgcgcga cgccgccacc ggtgtgcgcg tgcccgtgcg cacccgcccc    16620

cctcgcactt gaagatgttc acttcgcgat gttgatgtgt cccagcggcg aggaggatgt    16680

ccaagcgcaa attcaaggaa gagatgctcc aggtcatcgc gcctgagatc tacggccctg    16740

cggtggtgaa ggaggaaaga aagccccgca aaatcaagcg ggtcaaaaag gacaaaaagg    16800

aagaagaaag tgatgtggac ggattggtgg agtttgtgcg cgagttcgcc ccccggcggc    16860

gcgtgcagtg gcgcgggcgg aaggtgcaac cggtgctgag acccggcacc accgtggtct    16920

tcacgcccgg cgagcgctcc ggcaccgctt ccaagcgctc ctacgacgag gtgtacgggg    16980

atgatgatat tctggagcag gcggccgagc gcctgggcga gtttgcttac ggcaagcgca    17040

gccgttccgc accgaaggaa gaggcggtgt ccatcccgct ggaccacggc aaccccacgc    17100

cgagcctcaa gcccgtgacc ttgcagcagg tgctgccgac cgcggcgccg cgccgggggt    17160

tcaagcgcga gggcgaggat ctgtacccca ccatgcagct gatggtgccc aagcgccaga    17220

agctggaaga cgtgctggag accatgaagg tggacccgga cgtgcagccc gaggtcaagg    17280

tgcggcccat caagcaggtg gccccgggcc tgggcgtgca gaccgtggac atcaagattc    17340

ccacggagcc catggaaacg cagaccgagc ccatgatcaa gcccagcacc agcaccatgg    17400

aggtgcagac ggatccctgg atgccatcgg ctcctagtcg aagaccccgg cgcaagtacg    17460

gcgcggccag cctgctgatg cccaactacg cgctgcatcc ttccatcatc cccacgccgg    17520

gctaccgcgg cacgcgcttc taccgcggtc ataccagcag ccgccgccgc aagaccacca    17580

ctcgccgccg ccgtcgccgc accgccgctg caaccacccc tgccgccctg gtgcggagag    17640

tgtaccgccg cggccgcgca cctctgaccc tgccgcgcgc gcgctaccac ccgagcatcg    17700

ccatttaaac tttcgcctgc tttgcagatc aatggccctc acatgccgcc ttcgcgttcc    17760

cattacgggc taccgaggaa gaaaaccgcg ccgtagaagg ctggcgggga acgggatgcg    17820

tcgccaccac caccggcggc ggcgcgccat cagcaagcgg ttggggggag gcttcctgcc    17880

cgcgctgatc cccatcatcg ccgcggcgat cggggcgatc cccggcattg cttccgtggc    17940

ggtgcaggcc tctcagcgcc actgagacac acttggaaac atcttgtaat aaaccaatgg    18000

actctgacgc tcctggtcct gtgatgtgtt ttcgtagaca gatggaagac atcaattttt    18060

cgtccctggc tccgcgacac ggcacgcggc cgttcatggg cacctggagc gacatcggca    18120

ccagccaact gaacgggggc gccttcaatt ggagcagtct ctggagcggg cttaagaatt    18180

tcgggtccac gcttaaaacc tatggcagca aggcgtggaa cagcaccaca gggcaggcgc    18240

tgagggataa gctgaaagag cagaacttcc agcagaaggt ggtcgatggg ctcgcctcgg    18300

gcatcaacgg ggtggtggac ctggccaacc aggccgtgca gcggcagatc aacagccgcc    18360

tggacccggt gccgcccgcc ggctccgtgg agatgccgca ggtggaggag gagctgcctc    18420

ccctggacaa gcggggcgag aagcgacccc gccccgatgc ggaggagacg ctgctgacgc    18480

acacggacga gccgcccccg tacgaggagg cggtgaaact gggtctgccc accacgcggc    18540

ccatcgcgcc cctggccacc ggggtgctga aacccgaaaa gcccgcgacc ctggacttgc    18600

ctcctcccca gccttcccgc ccctctacag tggctaagcc cctgccgccg gtggccgtgg    18660

cccgcgcgcg acccgggggc accgcccgcc ctcatgcgaa ctggcagagc actctgaaca    18720

gcatcgtggg tctgggagtg cagagtgtga agcgccgccg ctgctattaa acctaccgta    18780

gcgcttaact tgcttgtctg tgtgtgtatg tattatgtcg ccgccgccgc tgtccaccag    18840

aaggaggagt gaagaggcgc gtcgccgagt tgcaagatgg ccaccccatc gatgctgccc    18900

cagtgggcgt acatgcacat cgccggacag gacgcttcgg agtacctgag tccgggtctg    18960

gtgcagtttg cccgcgccac agacacctac ttcagtctgg ggaacaagtt taggaacccc    19020

acggtggcgc ccacgcacga tgtgaccacc gaccgcagcc agcggctgac gctgcgcttc    19080

gtgcccgtgg accgcgagga caacacctac tcgtacaaag tgcgctacac gctggccgtg    19140

ggcgacaacc gcgtgctgga catggccagc acctactttg acatccgcgg cgtgctggat    19200

cggggcccta gcttcaaacc ctactccggc accgcctaca acagtctggc ccccaaggga    19260

gcacccaaca cttgtcagtg gacatataaa gccgatggtg aaactgccac agaaaaaacc    19320

tatacatatg gaaatgcacc cgtgcagggc attaacatca caaaagatgg tattcaactt    19380

ggaactgaca ccgatgatca gccaatctac gcagataaaa cctatcagcc tgaacctcaa    19440

gtgggtgatg ctgaatggca tgacatcact ggtactgatg aaaagtatgg aggcagagct    19500

cttaagcctg ataccaaaat gaagccttgt tatggttctt ttgccaagcc tactaataaa    19560

gaaggaggtc aggcaaatgt gaaaacagga acaggcacta ctaaagaata tgacatagac    19620

atggctttct ttgacaacag aagtgcggct gctgctggcc tagctccaga aattgttttg    19680

tatactgaaa atgtggattt ggaaactcca gatacccata ttgtatacaa agcaggcaca    19740

gatgacagca gctcttctat taatttgggt cagcaagcca tgcccaacag acctaactac    19800

attggtttca gagacaactt tatcgggctc atgtactaca acagcactgg caatatgggg    19860

gtgctggccg gtcaggcttc tcagctgaat gctgtggttg acttgcaaga cagaaacacc    19920

gagctgtcct accagctctt gcttgactct ctgggtgaca gaacccggta tttcagtatg    19980

tggaatcagg cggtggacag ctatgatcct gatgtgcgca ttattgaaaa tcatggtgtg    20040

gaggatgaac ttcccaacta ttgtttccct ctggatgctg ttggcagaac agatacttat    20100

cagggaatta aggctaatgg aactgatcaa accacatgga ccaaagatga cagtgtcaat    20160

gatgctaatg agataggcaa gggtaatcca ttcgccatgg aaatcaacat ccaagccaac    20220

ctgtggagga acttcctcta cgccaacgtg gccctgtacc tgcccgactc ttacaagtac    20280

acgccggcca atgttaccct gcccaccaac accaacacct acgattacat gaacggccgg    20340

gtggtggcgc cctcgctggt ggactcctac atcaacatcg gggcgcgctg gtcgctggat    20400

cccatggaca acgtgaaccc cttcaaccac caccgcaatg cggggctgcg ctaccgctcc    20460

atgctcctgg gcaacgggcg ctacgtgccc ttccacatcc aggtgcccca gaaatttttc    20520

gccatcaaga gcctcctgct cctgcccggg tcctacacct acgagtggaa cttccgcaag    20580

gacgtcaaca tgatcctgca gagctccctc ggcaacgacc tgcgcacgga cggggcctcc    20640

atctccttca ccagcatcaa cctctacgcc accttcttcc ccatggcgca caacacggcc    20700

tccacgctcg aggccatgct gcgcaacgac accaacgacc agtccttcaa cgactacctc    20760

tcggcggcca acatgctcta ccccatcccg gccaacgcca ccaacgtgcc catctccatc    20820

ccctcgcgca actgggccgc cttccgcggc tggtccttca cgcgtctcaa gaccaaggag    20880

acgccctcgc tgggctccgg gttcgacccc tacttcgtct actcgggctc catcccctac    20940

ctcgacggca ccttctacct caaccacacc ttcaagaagg tctccatcac cttcgactcc    21000

tccgtcagct ggcccggcaa cgaccggctc ctgacgccca acgagttcga aatcaagcgc    21060

accgtcgacg gcgagggcta caacgtggcc cagtgcaaca tgaccaagga ctggttcctg    21120

gtccagatgc tggcccacta caacatcggc taccagggct tctacgtgcc cgagggctac    21180

aaggaccgca tgtactcctt cttccgcaac ttccagccca tgagccgcca ggtggtggac    21240

gaggtcaact acaaggacta ccaggccgtc accctggcct accagcacaa caactcgggc    21300

ttcgtcggct acctcgcgcc caccatgcgc cagggccagc cctaccccgc caactacccc    21360

tacccgctca tcggcaagag cgccgtcacc agcgtcaccc agaaaaagtt cctctgcgac    21420

agggtcatgt ggcgcatccc cttctccagc aacttcatgt ccatgggcgc gctcaccgac    21480

ctcggccaga acatgctcta tgccaactcc gcccacgcgc tagacatgaa tttcgaagtc    21540

gaccccatgg atgagtccac ccttctctat gttgtcttcg aagtcttcga cgtcgtccga    21600

gtgcaccagc cccaccgcgg cgtcatcgag gccgtctacc tgcgcacccc cttctcggcc    21660

ggtaacgcca ccacctaagc tcttgcttct tgcaagccat ggccgcgggc tccggcgagc    21720

aggagctcag ggccatcatc cgcgacctgg gctgcgggcc ctacttcctg ggcaccttcg    21780

ataagcgctt cccgggattc atggccccgc acaagctggc ctgcgccatc gtcaacacgg    21840

ccggccgcga gaccgggggc gagcactggc tggccttcgc ctggaacccg cgctcgaaca    21900

cctgctacct cttcgacccc ttcgggttct cggacgagcg cctcaagcag atctaccagt    21960

tcgagtacga gggcctgctg cgccgcagcg ccctggccac cgaggaccgc tgcgtcaccc    22020

tggaaaagtc cacccagacc gtgcagggtc cgcgctcggc cgcctgcggg ctcttctgct    22080

gcatgttcct gcacgccttc gtgcactggc ccgaccgccc catggacaag aaccccacca    22140

tgaacttgct gacgggggtg cccaacggca tgctccagtc gccccaggtg gaacccaccc    22200

tgcgccgcaa ccaggaggcg ctctaccgct tcctcaactc ccactccgcc tactttcgct    22260

cccaccgcgc gcgcatcgag aaggccaccg ccttcgaccg catgaatcaa gacatgtaaa    22320

ccgtgtgtgt atgttaaatg tctttaataa acagcacttt catgttacac atgcatctga    22380

gatgatttat ttagaaatcg aaagggttct gccgggtctc ggcatggccc gcgggcaggg    22440

acacgttgcg gaactggtac ttggccagcc acttgaactc ggggatcagc agtttgggca    22500

gcggggtgtc ggggaaggag tcggtccaca gcttccgcgt cagttgcagg gcgcccagca    22560

ggtcgggcgc ggagatcttg aaatcgcagt tgggacccgc gttctgcgcg cgggagttgc    22620

ggtacacggg gttgcagcac tggaacacca tcagggccgg gtgcttcacg ctcgccagca    22680

ccgtcgcgtc ggtgatgctc tccacgtcga ggtcctcggc gttggccatc ccgaaggggg    22740

tcatcttgca ggtctgcctt cccatggtgg gcacgcaccc gggcttgtgg ttgcaatcgc    22800

agtgcagggg gatcagcatc atctgggcct ggtcggcgtt catccccggg tacatggcct    22860

tcatgaaagc ctccaattgc ctgaacgcct gctgggcctt ggctccctcg gtgaagaaga    22920

ccccgcagga cttgctagag aactggttgg tggcgcaccc ggcgtcgtgc acgcagcagc    22980

gcgcgtcgtt gttggccagc tgcaccacgc tgcgccccca gcggttctgg gtgatcttgg    23040

cccggtcggg gttctccttc agcgcgcgct gcccgttctc gctcgccaca tccatctcga    23100

tcatgtgctc cttctggatc atggtggtcc cgtgcaggca ccgcagcttg ccctcggcct    23160

cggtgcaccc gtgcagccac agcgcgcacc cggtgcactc ccagttcttg tgggcgatct    23220

gggaatgcgc gtgcacgaag ccctgcagga agcggcccat catggtggtc agggtcttgt    23280

tgctagtgaa ggtcagcgga atgccgcggt gctcctcgtt gatgtacagg tggcagatgc    23340

ggcggtacac ctcgccctgc tcgggcatca gctggaagtt ggctttcagg tcggtctcca    23400

cgcggtagcg gtccatcagc atagtcatga tttccatacc cttctcccag gccgagacga    23460

tgggcaggct catagggttc ttcaccatca tcttagcgct agcagccgcg gccagggggt    23520

cgctctcgtc cagggtctca aagctccgct tgccgtcctt ctcggtgatc cgcaccgggg    23580

ggtagctgaa gcccacggcc gccagctcct cctcggcctg tctttcgtcc tcgctgtcct    23640

ggctgacgtc ctgcaggacc acatgcttgg tcttgcgggg tttcttcttg ggcggcagcg    23700

gcggcggaga tgttggagat ggcgaggggg agcgcgagtt ctcgctcacc actactatct    23760

cttcctcttc ttggtccgag gccacgcggc ggtaggtatg tctcttcggg ggcagaggcg    23820

gaggcgacgg gctctcgccg ccgcgacttg gcggatggct ggcagagccc cttccgcgtt    23880

cgggggtgcg ctcccggcgg cgctctgact gacttcctcc gcggccggcc attgtgttct    23940

cctagggagg aacaacaagc atggagactc agccatcgcc aacctcgcca tctgccccca    24000

ccgccgacga gaagcagcag cagcagaatg aaagcttaac cgccccgccg cccagccccg    24060

ccacctccga cgcggccgtc ccagacatgc aagagatgga ggaatccatc gagattgacc    24120

tgggctatgt gacgcccgcg gagcacgagg aggagctggc agtgcgcttt tcacaagaag    24180

agatacacca agaacagcca gagcaggaag cagagaatga gcagagtcag gctgggctcg    24240

agcatgacgg cgactacctc cacctgagcg ggggggagga cgcgctcatc aagcatctgg    24300

cccggcaggc caccatcgtc aaggatgcgc tgctcgaccg caccgaggtg cccctcagcg    24360

tggaggagct cagccgcgcc tacgagttga acctcttctc gccgcgcgtg ccccccaagc    24420

gccagcccaa tggcacctgc gagcccaacc cgcgcctcaa cttctacccg gtcttcgcgg    24480

tgcccgaggc cctggccacc taccacatct ttttcaagaa ccaaaagatc cccgtctcct    24540

gccgcgccaa ccgcacccgc gccgacgccc ttttcaacct gggtcccggc gcccgcctac    24600

ctgatatcgc ctccttggaa gaggttccca agatcttcga gggtctgggc agcgacgaga    24660

ctcgggccgc gaacgctctg caaggagaag gaggagagca tgagcaccac agcgccctgg    24720

tcgagttgga aggcgacaac gcgcggctgg cggtgctcaa acgcacggtc gagctgaccc    24780

atttcgccta cccggctctg aacctgcccc ccaaagtcat gagcgcggtc atggaccagg    24840

tgctcatcaa gcgcgcgtcg cccatctccg aggacgaggg catgcaagac tccgaggagg    24900

gcaagcccgt ggtcagcgac gagcagctgg cccggtggct gggtcctaat gctagtcccc    24960

agagtttgga agagcggcgc aaactcatga tggccgtggt cctggtgacc gtggagctgg    25020

agtgcctgcg ccgcttcttc gccgacgcgg agaccctgcg caaggtcgag gagaacctgc    25080

actacctctt caggcacggg ttcgtgcgcc aggcctgcaa gatctccaac gtggagctga    25140

ccaacctggt ctcctacatg ggcatcttgc acgagaaccg cctggggcag aacgtgctgc    25200

acaccaccct gcgcggggag gcccggcgcg actacatccg cgactgcgtc tacctctacc    25260

tctgccacac ctggcagacg ggcatgggcg tgtggcagca gtgtctggag gagcagaacc    25320

tgaaagagct ctgcaagctc ctgcagaaga acctcaaggg tctgtggacc gggttcgacg    25380

agcgcaccac cgcctcggac ctggccgacc tcattttccc cgagcgcctc aggctgacgc    25440

tgcgcaacgg cctgcccgac tttatgagcc aaagcatgtt gcaaaacttt cgctctttca    25500

tcctcgaacg ctccggaatc ctgcccgcca cctgctccgc gctgccctcg gacttcgtgc    25560

cgctgacctt ccgcgagtgc cccccgccgc tgtggagcca ctgctacctg ctgcgcctgg    25620

ccaactacct ggcctaccac tcggacgtga tcgaggacgt cagcggcgag ggcctgctcg    25680

agtgccactg ccgctgcaac ctctgcacgc cgcaccgctc cctggcctgc aacccccagc    25740

tgctgagcga gacccagatc atcggcacct tcgagttgca agggcccagc gaaggcgagg    25800

gttcagccgc caaggggggt ctgaaactca ccccggggct gtggacctcg gcctacttgc    25860

gcaagttcgt gcccgaggac taccatccct tcgagatcag gttctacgag gaccaatccc    25920

atccgcccaa ggccgagctg tcggcctgcg tcatcaccca gggggcgatc ctggcccaat    25980

tgcaagccat ccagaaatcc cgccaagaat tcttgctgaa aaagggccgc ggggtctacc    26040

tcgaccccca gaccggtgag gagctcaacc ccggcttccc ccaggatgcc ccgaggaaac    26100

aagaagctga aagtggagct gccgcccgtg gaggatttgg aggaagactg ggagaacagc    26160

agtcaggcag aggaggagga gatggaggaa gactgggaca gcactcaggc agaggaggac    26220

agcctgcaag acagtctgga ggaagacgag gaggaggcag aggaggaggt ggaagaagca    26280

gccgccgcca gaccgtcgtc ctcggcgggg gagaaagcaa gcagcacgga taccatctcc    26340

gctccgggtc ggggtcccgc tcgaccacac agtagatggg acgagaccgg acgattcccg    26400

aaccccacca cccagaccgg taagaaggag cggcagggat acaagtcctg gcgggggcac    26460

aaaaacgcca tcgtctcctg cttgcaggcc tgcgggggca acatctcctt cacccggcgc    26520

tacctgctct tccaccgcgg ggtgaacttt ccccgcaaca tcttgcatta ctaccgtcac    26580

ctccacagcc cctactactt ccaagaagag gcagcagcag cagaaaaaga ccagcagaaa    26640

accagcagct agaaaatcca cagcggcggc agcaggtgga ctgaggatcg cggcgaacga    26700

gccggcgcaa acccgggagc tgaggaaccg gatctttccc accctctatg ccatcttcca    26760

gcagagtcgg gggcaggagc aggaactgaa agtcaagaac cgttctctgc gctcgctcac    26820

ccgcagttgt ctgtatcaca agagcgaaga ccaacttcag cgcactctcg aggacgccga    26880

ggctctcttc aacaagtact gcgcgctcac tcttaaagag tagcccgcgc ccgcccagtc    26940

gcagaaaaag gcgggaatta cgtcacctgt gcccttcgcc ctagccgcct ccacccatca    27000

tcatgagcaa agagattccc acgccttaca tgtggagcta ccagccccag atgggcctgg    27060

ccgccggtgc cgcccaggac tactccaccc gcatgaattg gctcagcgcc gggcccgcga    27120

tgatctcacg ggtgaatgac atccgcgccc accgaaacca gatactccta gaacagtcag    27180

cgctcaccgc cacgccccgc aatcacctca atccgcgtaa ttggcccgcc gccctggtgt    27240

accaggaaat tccccagccc acgaccgtac tacttccgcg agacgcccag gccgaagtcc    27300

agctgactaa ctcaggtgtc cagctggcgg gcggcgccac cctgtgtcgt caccgccccg    27360

ctcagggtat aaagcggctg gtgatccggg gcagaggcac acagctcaac gacgaggtgg    27420

tgagctcttc gctgggtctg cgacctgacg gagtcttcca actcgccgga tcggggagat    27480

cttccttcac gcctcgtcag gccgtcctga ctttggagag ttcgtcctcg cagccccgct    27540

cgggtggcat cggcactctc cagttcgtgg aggagttcac tccctcggtc tacttcaacc    27600

ccttctccgg ctcccccggc cactacccgg acgagttcat cccgaacttc gacgccatca    27660

gcgagtcggt ggacggctac gattgaatgt cccatggtgg cgcagctgac ctagctcggc    27720

ttcgacacct ggaccactgc cgccgcttcc gctgcttcgc tcgggatctc gccgagtttg    27780

cctactttga gctgcccgag gagcaccctc agggcccggc ccacggagtg cggatcgtcg    27840

tcgaaggggg cctcgactcc cacctgcttc ggatcttcag ccagcgtccg atcctggtcg    27900

agcgcgagca aggacagacc cttctgactc tgtactgcat ctgcaaccac cccggcctgc    27960

atgaaagtct ttgttgtctg ctgtgtactg agtataataa aagctgagat cagcgactac    28020

tccggacttc cgtgtgttcc tgaatccatc aaccagtctt tgttcttcac cgggaacgag    28080

accgagctcc agctccagtg taagccccac aagaagtacc tcacctggct gttccagggc    28140

tccccgatcg ccgttgtcaa ccactgcgac aacgacggag tcctgctgag cggccctgcc    28200

aaccttactt tttccacccg cagaagcaag ctccagctct tccaaccctt cctccccggg    28260

acctatcagt gcgtctcggg accctgccat cacaccttcc acctgatccc gaataccaca    28320

gcgtcgctcc ccgctactaa caaccaaact aacctccacc aacgccaccg tcgctaggcc    28380

acaatacatg cccatattag actatgaggc cgagccacag cgacccatgc tccccgctat    28440

tagttacttc aatctaaccg gcggagatga ctgacccact ggccaacaac aacgtcaacg    28500

accttctcct ggacatggac ggccgcgcct cggagcagcg actcgcccaa cttcgcattc    28560

gccagcagca ggagagagcc gtcaaggagc tgcaggatgc ggtggccatc caccagtgca    28620

agagaggcat cttctgcctg gtgaaacagg ccaagatctc ctacgaggtc actccaaacg    28680

accatcgcct ctcctacgag ctcctgcagc agcgccagaa gttcacctgc ctggtcggag    28740

tcaaccccat cgtcatcacc cagcagtctg gcgataccaa ggggtgcatc cactgctcct    28800

gcgactcccc cgactgcgtc cacactctga tcaagaccct ctgcggcctc cgcgacctcc    28860

tccccatgaa ctaatcaccc ccttatccag tgaaataaag atcatattga tgatgatttt    28920

acagaaataa aaaataatca tttgatttga aataaagata caatcatatt gatgatttga    28980

gtttaacaaa aaaataaaga atcacttact tgaaatctga taccaggtct ctgtccatgt    29040

tttctgccaa caccacttca ctcccctctt cccagctctg gtactgcagg ccccggcggg    29100

ctgcaaactt cctccacacg ctgaagggga tgtcaaattc ctcctgtccc tcaatcttca    29160

ttttatcttc tatcagatgt ccaaaaagcg cgtccgggtg gatgatgact tcgaccccgt    29220

ctacccctac gatgcagaca acgcaccgac cgtgcccttc atcaaccccc ccttcgtctc    29280

ttcagatgga ttccaagaga agcccctggg ggtgttgtcc ctgcgactgg ccgaccccgt    29340

caccaccaag aacggggaaa tcaccctcaa gctgggagag ggggtggacc tcgattcctc    29400

gggaaaactc atctccaaca cggccaccaa ggccgccgcc cctctcagtt tttccaacaa    29460

caccatttcc cttaacatgg atcacccctt ttacactaaa gatggaaaat tatccttaca    29520

agtttctcca ccattaaata tactgagaac aagcattcta aacacactag ctttaggttt    29580

tggatcaggt ttaggactcc gtggctctgc cttggcagta cagttagtct ctccacttac    29640

atttgatact gatggaaaca taaagcttac cttagacaga ggtttgcatg ttacaacagg    29700

agatgcaatt gaaagcaaca taagctgggc taaaggttta aaatttgaag atggagccat    29760

agcaaccaac attggaaatg ggttagagtt tggaagcagt agtacagaaa caggtgttga    29820

tgatgcttac ccaatccaag ttaaacttgg atctggcctt agctttgaca gtacaggagc    29880

cataatggct ggtaacaaag aagacgataa actcactttg tggacaacac ctgatccatc    29940

accaaactgt caaatactcg cagaaaatga tgcaaaacta acactttgct tgactaaatg    30000

tggtagtcaa atactggcca ctgtgtcagt cttagttgta ggaagtggaa acctaaaccc    30060

cattactggc accgtaagca gtgctcaggt gtttctacgt tttgatgcaa acggtgttct    30120

tttaacagaa cattctacac taaaaaaata ctgggggtat aggcagggag atagcataga    30180

tggcactcca tataccaatg ctgtaggatt catgcccaat ttaaaagctt atccaaagtc    30240

acaaagttct actactaaaa ataatatagt agggcaagta tacatgaatg gagatgtttc    30300

aaaacctatg cttctcacta taaccctcaa tggtactgat gacagcaaca gtacatattc    30360

aatgtcattt tcatacacct ggactaatgg aagctatgtt ggagcaacat ttggggctaa    30420

ctcttatacc ttctcataca tcgcccaaga atgaacactg tatcccaccc tgcatgccaa    30480

cccttcccac cccactctgt ggaacaaact ctgaaacaca aaataaaata aagttcaagt    30540

gttttattga ttcaacagtt ttacaggatt cgagcagtta tttttcctcc accctcccag    30600

gacatggaat acaccaccct ctccccccgc acagccttga acatctgaat gccattggtg    30660

atggacatgc ttttggtctc cacgttccac acagtttcag agcgagccag tctcgggtcg    30720

gtcagggaga tgaaaccctc cgggcactcc cgcatctgca cctcacagct caacagctga    30780

ggattgtcct cggtggtcgg gatcacggtt atctggaaga agcagaagag cggcggtggg    30840

aatcatagtc cgcgaacggg atcggccggt ggtgtcgcat caggccccgc agcagtcgct    30900

gccgccgccg ctccgtcaag ctgctgctca gggggtccgg gtccagggac tccctcagca    30960

tgatgcccac ggccctcagc atcagtcgtc tggtgcggcg ggcgcagcag cgcatgcgga    31020

tctcgctcag gtcgctgcag tacgtgcaac acagaaccac caggttgttc aacagtccat    31080

agttcaacac gctccagccg aaactcatcg cgggaaggat gctacccacg tggccgtcgt    31140

accagatcct caggtaaatc aagtggtgcc ccctccagaa cacgctgccc acgtacatga    31200

tctccttggg catgtggcgg ttcaccacct cccggtacca catcaccctc tggttgaaca    31260

tgcagccccg gatgatcctg cggaaccaca gggccagcac cgccccgccc gccatgcagc    31320

gaagagaccc cgggtcccgg caatggcaat ggaggaccca ccgctcgtac ccgtggatca    31380

tctgggagct gaacaagtct atgttggcac agcacaggca tatgctcatg catctcttca    31440

gcactctcaa ctcctcgggg gtcaaaacca tatcccaggg cacggggaac tcttgcagga    31500

cagcgaaccc cgcagaacag ggcaatcctc gcacagaact tacattgtgc atggacaggg    31560

tatcgcaatc aggcagcacc gggtgatcct ccaccagaga agcgcgggtc tcggtctcct    31620

cacagcgtgg taagggggcc ggccgatacg ggtgatggcg ggacgcggct gatcgtgttc    31680

gcgaccgtgt catgatgcag ttgctttcgg acattttcgt acttgctgta gcagaacctg    31740

gtccgggcgc tgcacaccga tcgccggcgg cggtctcggc gcttggaacg ctcggtgttg    31800

aaattgtaaa acagccactc tctcagaccg tgcagcagat ctagggcctc aggagtgatg    31860

aagatcccat catgcctgat ggctctgatc acatcgacca ccgtggaatg ggccagaccc    31920

agccagatga tgcaattttg ttgggtttcg gtgacggcgg gggagggaag aacaggaaga    31980

accatgatta acttttaatc caaacggtct cggagtactt caaaatgaag atcgcggaga    32040

tggcacctct cgcccccgct gtgttggtgg aaaataacag ccaggtcaaa ggtgatacgg    32100

ttctcgagat gttccacggt ggcttccagc aaagcctcca cgcgcacatc cagaaacaag    32160

acaatagcga aagcgggagg gttctctaat tcctcaatca tcatgttaca ctcctgcacc    32220

atccccagat aattttcatt tttccagcct tgaatgattc gaactagttc ctgaggtaaa    32280

tccaagccag ccatgataaa gagctcgcgc agagcgccct ccaccggcat tcttaagcac    32340

accctcataa ttccaagata ttctgctcct ggttcacctg cagcagattg acaagcggaa    32400

tatcaaaatc tctgccgcga tccctgagct cctccctcag caataactgt aagtactctt    32460

tcatatcctc tccgaaattt ttagccatag gaccaccagg aataagatta gggcaagcca    32520

cagtacagat aaaccgaagt cctccccagt gagcattgcc aaatgcaaga ctgctataag    32580

catgctggct agacccggtg atatcttcca gataactgga cagaaaatcg cccaggcaat    32640

ttttaagaaa atcaacaaaa gaaaaatcct ccaggtggac gtttagagcc tcgggaacaa    32700

cgatgaagta aatgcaagcg gtgcgttcca gcatggttag ttagctgatc tgtagaaaaa    32760

acaaaaatga acattaaacc atgctagcct ggcgaacagg tgggtaaatc gttctctcca    32820

gcaccaggca ggccacgggg tctccggcgc gaccctcgta aaaattgtcg ctatgattga    32880

aaaccatcac agagagacgt tcccggtggc cggcgtgaat gattcgacaa gatgaataca    32940

cccccggaac attggcgtcc gcgagtgaaa aaaagcgccc gaggaagcaa taaggcacta    33000

caatgctcag tctcaagtcc agcaaagcga tgccatgcgg atgaagcaca aaattctcag    33060

gtgcgtacaa aatgtaatta ctcccctcct gcacaggcag caaagccccc gatccctcca    33120

ggtacacata caaagcctca gcgtccatag cttaccgagc agcagcacac aacaggcgca    33180

agagtcagag aaaggctgag ctctaacctg tccacccgct ctctgctcaa tatatagccc    33240

agatctacac tgacgtaaag gccaaagtct aaaaataccc gccaaataat cacacacgcc    33300

cagcacacgc ccagaaaccg gtgacacact caaaaaaata cgcgcacttc ctcaaacgcc    33360

caaaactgcc gtcatttccg ggttcccacg ctacgtcatc aaaacacgac tttcaaattc    33420

cgtcgaccgt taaaaacgtc acccgccccg cccctaacgg tcgcccgtct ctcagccaat    33480

cagcgccccg catccccaaa ttcaaacacc tcatttgcat attaacgcgc acaaaaagtt    33540

tgaggtatat tattgatgat gg                                             33562


<210>  45
<211>  34803
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  45
ccatcttcaa taatatacct caaacttttt gtgcgcgtta atatgcaaat gaggcgtttg       60

aatttgggga ggaagggcgg tgattggtcg agggatgagc gaccgttagg ggcggggcga      120

gtgacgtttt gatgacgtgg ttgcgaggag gagccagttt gcaagttctc gtgggaaaag      180

tgacgtcaaa cgaggtgtgg tttgaacacg gaaatactca attttcccgc gctctctgac      240

aggaaatgag gtgtttctgg gcggatgcaa gtgaaaacgg gccattttcg cgcgaaaact      300

gaatgaggaa gtgaaaatct gagtaatttc gcgtttatgg cagggaggag tatttgccga      360

gggccgagta gactttgacc gattacgtgg gggtttcgat taccgtgttt ttcacctaaa      420

tttccgcgta cggtgtcaaa gtccggtgtt tttactactg taatagtaat caattacggg      480

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      540

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      600

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      660

ccacttggca gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga      720

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg      780

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacat      840

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      900

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactc      960

cgccccattg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc     1020

tgtccctatc agtgatagag atctccctat cagtgataga gagtttagtg aaccgtcaga     1080

tccgctaggg taccaacatg gctagcatcg tcggagggtg ggagtgcgaa aagcactcac     1140

agccatggca ggtcctggtc gcctcgcgcg gacgcgccgt gtgtggaggt gtgctggtcc     1200

acccgcagtg ggtgttgact gcggcccatt gcatcagaaa taagtccgtg atcctcttgg     1260

ggagacattc cctgtttcac cccgaagata ctggacaggt gttccaagtg agccactcct     1320

tcccgcatcc actgtacgac atgagcctgc tgaagaaccg ctttctgcgg ccaggggacg     1380

actcatcaca cgatttgatg ctgcttcggc tctcggaacc ggccgagctc accgacgcag     1440

tgaaggtcat ggacctccct acgcaagagc ctgctctcgg taccacttgt tacgcatcgg     1500

gatggggctc catcgagccg gaagaattcc tgaccccgaa aaagctgcag tgcgtggatc     1560

tgcacgtgat ttcgaatgac gtgtgcgcgc aagtgcatcc acaaaaggtc actaagttca     1620

tgctgtgcgc cggaaggtgg accggcggaa aatcgacctg ttccggcgac agcggaggcc     1680

cactcgtgtg caacggtgtg ctgcagggca tcactagctg gggatcagaa ccgtgcgcgc     1740

ttccggagcg gccctcgctc tacacgaagg tggtgcacta ccgcaaatgg attaaagata     1800

ccatcgtcgc aaaccctgga tccgaaggta ggggttcatt attgacctgt ggagatgtcg     1860

aagaaaaccc aggacccgct agcaaagcag tgctgctggc gctcctgatg gctggactcg     1920

cgctgcagcc tggaaccgcc ctgctctgtt actcgtgcaa ggcccaagtc tcgaatgagg     1980

actgtttgca agtggaaaac tgcacccagc tcggagaaca atgctggact gcacggatcc     2040

gcgctgtcgg cctgctgacc gtgatctcca aagggtgctc attgaactgc gtggacgata     2100

gccaggacta ctacgtggga aagaagaata tcacttgttg cgacacggat ctttgcaacg     2160

cgtccggagc gcacgccctg cagccagcag ccgccattct ggccctgctt ccggccctgg     2220

ggttgctgct ctggggtccg ggccagctcg gatcccagac cctgaacttt gatctgctga     2280

aactggcagg cgatgtggaa agcaacccag gcccaatggc tagcgctcgc agaccgcggt     2340

ggctgtgtgc aggggcgctc gtcctggcgg gtggcttctt tttgctcggc tttcttttcg     2400

gatggttcat caaatcgtca aacgaagcta ccaatatcac cccgaagcac aacatgaagg     2460

cctttctgga tgagctgaag gctgagaaca ttaagaagtt cctctacaac ttcacccaga     2520

tcccacattt ggcgggcact gagcagaact ttcagttggc taagcagatc cagagccagt     2580

ggaaggaatt cggcctggac tccgtcgagc tggcgcatta cgatgtgctg ctgagctacc     2640

ctaataagac tcatccgaac tatatctcga ttatcaatga ggacggaaac gaaatcttta     2700

acacgtccct cttcgagccg ccaccgcctg gatacgagaa cgtgtcagat atcgtgcctc     2760

cgttctcggc cttctcgccc cagggaatgc ccgaagggga cctggtgtac gtgaactacg     2820

caaggaccga ggacttcttc aagttggagc gggatatgaa gatcaattgc agcggaaaga     2880

tcgtcatcgc ccgctacggc aaagtgttcc gcggcaacaa ggtgaagaat gcacagttgg     2940

caggcgccaa gggcgtcatc ctctactcgg atcctgccga ctacttcgct cctggcgtga     3000

aatcctaccc tgatggttgg aatctgccag gaggaggggt gcagagggga aatatcctga     3060

acctgaacgg tgccggtgac ccacttactc cgggttaccc ggccaacgaa tacgcgtaca     3120

ggcggggtat cgcggaagcc gtcggactgc cgtccatccc ggtccatccg attggttact     3180

acgacgccca gaagctcctc gaaaagatgg gaggcagcgc ccctccggac tcgtcatgga     3240

gaggctcgct gaaggtgcca tacaacgtgg gacccggatt cactggaaat ttcagcactc     3300

aaaaagtgaa gatgcacatt cactccacta acgaagtcac caggatctac aacgtcatcg     3360

gaaccctccg gggagcggtg gaaccggacc gctacgtgat cctcggtgga caccgggata     3420

gctgggtgtt cggaggaatc gatcctcaat cgggcgcagc cgtcgtccat gaaatcgtca     3480

ggtcctttgg tactcttaag aaggagggct ggcgccctag acgcactatt ctgttcgcct     3540

cgtgggatgc cgaagaattt ggtctgctcg gcagcaccga atgggctgag gaaaactccc     3600

gcctgctcca agaacgcgga gtggcgtaca tcaatgccga ctcatccatc gaaggaaact     3660

acacgctgcg ggtggactgc actccactga tgtactcgct cgtgcacaac ctgaccaaag     3720

aactcaaatc cccagacgaa ggattcgagg gaaaatcgct gtacgagtcg tggaccaaga     3780

agagcccatc cccggagttc agcgggatgc cgcggatctc aaagctcgga tcaggaaatg     3840

atttcgaagt gttctttcag aggctgggaa ttgcgtcggg aagggctcgg tacacgaaaa     3900

actgggaaac taacaagttc tcgggatacc cgctgtacca ctcggtgtat gaaacttacg     3960

aactggtgga gaaattctac gatcctatgt ttaagtacca cctgactgtg gcccaagtga     4020

gaggcggaat ggtgttcgag ttggccaatt caattgtgct gccattcgat tgccgcgact     4080

acgccgtggt gctgagaaag tacgcagaca aaatctactc aatcagcatg aagcacccac     4140

aagagatgaa aacctactca gtctccttcg actccctctt ctccgcggtg aagaacttca     4200

ccgagatcgc gagcaaattc tcggagcgcc ttcaagattt tgacaaatcc aatccgatcg     4260

tcctccgcat gatgaatgac cagctcatgt ttctcgaacg ggccttcatc gatccactgg     4320

gacttccgga ccggccgttt taccgccacg tgatctacgc gccctcgtcg cataacaagt     4380

atgctggaga gagcttcccg ggtatctacg acgcattgtt cgacattgag tccaaggtgg     4440

atccgtccaa agcctggggt gaagtgaagc gccaaatcta cgtggcggcc tttaccgtcc     4500

aggcggcagc agaaaccttg agcgaggtgg cttgactcga gcctaagctt ctagataaga     4560

tatccgatcc accggatcta gataactgat cataatcagc cataccacat ttgtagaggt     4620

tttacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata aaatgaatgc     4680

aattgttgtt gttaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat     4740

cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact     4800

catcaatgta tcttatatgc tggccaccgt acatgtggct tcccatgctc gcaagccctg     4860

gcccgagttc gagcacaatg tcatgaccag gtgcaatatg catctggggt cccgccgagg     4920

catgttcatg ccctaccagt gcaacctgaa ttatgtgaag gtgctgctgg agcccgatgc     4980

catgtccaga gtgagcctga cgggggtgtt tgacatgaat gtggaggtgt ggaagattct     5040

gagatatgat gaatccaaga ccaggtgccg agcctgcgag tgcggaggga agcatgccag     5100

gttccagccc gtgtgtgtgg atgtgacgga ggacctgcga cccgatcatt tggtgttgcc     5160

ctgcaccggg acggagttcg gttccagcgg ggaagaatct gactagagtg agtagtgttc     5220

tggggcgggg gaggacctgc atgagggcca gaataactga aatctgtgct tttctgtgtg     5280

ttgcagcagc atgagcggaa gcggctcctt tgagggaggg gtattcagcc cttatctgac     5340

ggggcgtctc ccctcctggg cgggagtgcg tcagaatgtg atgggatcca cggtggacgg     5400

ccggcccgtg cagcccgcga actcttcaac cctgacctat gcaaccctga gctcttcgtc     5460

gttggacgca gctgccgccg cagctgctgc atctgccgcc agcgccgtgc gcggaatggc     5520

catgggcgcc ggctactacg gcactctggt ggccaactcg agttccacca ataatcccgc     5580

cagcctgaac gaggagaagc tgttgctgct gatggcccag ctcgaggcct tgacccagcg     5640

cctgggcgag ctgacccagc aggtggctca gctgcaggag cagacgcggg ccgcggttgc     5700

cacggtgaaa tccaaataaa aaatgaatca ataaataaac ggagacggtt gttgatttta     5760

acacagagtc tgaatcttta tttgattttt cgcgcgcggt aggccctgga ccaccggtct     5820

cgatcattga gcacccggtg gatcttttcc aggacccggt agaggtgggc ttggatgttg     5880

aggtacatgg gcatgagccc gtcccggggg tggaggtagc tccattgcag ggcctcgtgc     5940

tcgggggtgg tgttgtaaat cacccagtca tagcaggggc gcagggcatg gtgttgcaca     6000

atatctttga ggaggagact gatggccacg ggcagccctt tggtgtaggt gtttacaaat     6060

ctgttgagct gggagggatg catgcggggg gagatgaggt gcatcttggc ctggatcttg     6120

agattggcga tgttaccgcc cagatcccgc ctggggttca tgttgtgcag gaccaccagc     6180

acggtgtatc cggtgcactt ggggaattta tcatgcaact tggaagggaa ggcgtgaaag     6240

aatttggcga cgcctttgtg cccgcccagg ttttccatgc actcatccat gatgatggcg     6300

atgggcccgt gggcggcggc ctgggcaaag acgtttcggg ggtcggacac atcatagttg     6360

tggtcctggg tgaggtcatc ataggccatt ttaatgaatt tggggcggag ggtgccggac     6420

tgggggacaa aggtaccctc gatcccgggg gcgtagttcc cctcacagat ctgcatctcc     6480

caggctttga gctcggaggg ggggatcatg tccacctgcg gggcgataaa gaacacggtt     6540

tccggggcgg gggagatgag ctgggccgaa agcaagttcc ggagcagctg ggacttgccg     6600

cagccggtgg ggccgtagat gaccccgatg accggctgca ggtggtagtt gagggagaga     6660

cagctgccgt cctcccggag gaggggggcc acctcgttca tcatctcgcg cacgtgcatg     6720

ttctcgcgca ccagttccgc caggaggcgc tctcccccca gggataggag ctcctggagc     6780

gaggcgaagt ttttcagcgg cttgagtccg tcggccatgg gcattttgga gagggtttgt     6840

tgcaagagtt ccaggcggtc ccagagctcg gtgatgtgct ctacggcatc tcgatccagc     6900

agacctcctc gtttcgcggg ttgggacggc tgcgggagta gggcaccaga cgatgggcgt     6960

ccagcgcagc cagggtccgg tccttccagg gtcgcagcgt ccgcgtcagg gtggtctccg     7020

tcacggtgaa ggggtgcgcg ccgggctggg cgcttgcgag ggtgcgcttc aggctcatcc     7080

ggctggtcga aaaccgctcc cgatcggcgc cctgcgcgtc ggccaggtag caattgacca     7140

tgagttcgta gttgagcgcc tcggccgcgt ggcctttggc gcggagctta cctttggaag     7200

tctgcccgca ggcgggacag aggagggact tgagggcgta gagcttgggg gcgaggaaga     7260

cggactcggg ggcgtaggcg tccgcgccgc agtgggcgca gacggtctcg cactccacga     7320

gccaggtgag gtcgggctgg tcggggtcaa aaaccagttt cccgccgttc tttttgatgc     7380

gtttcttacc tttggtctcc atgagctcgt gtccccgctg ggtgacaaag aggctgtccg     7440

tgtccccgta gaccgacttt atgggccggt cctcgagcgg tgtgccgcgg tcctcctcgt     7500

agaggaaccc cgcccactcc gagacgaaag cccgggtcca ggccagcacg aaggaggcca     7560

cgtgggacgg gtagcggtcg ttgtccacca gcgggtccac cttttccagg gtatgcaaac     7620

acatgtcccc ctcgtccaca tccaggaagg tgattggctt gtaagtgtag gccacgtgac     7680

cgggggtccc ggccgggggg gtataaaagg gtgcgggtcc ctgctcgtcc tcactgtctt     7740

ccggatcgct gtccaggagc gccagctgtt ggggtaggta ttccctctcg aaggcgggca     7800

tgacctcggc actcaggttg tcagtttcta gaaacgagga ggatttgata ttgacggtgc     7860

cggcggagat gcctttcaag agcccctcgt ccatctggtc agaaaagacg atctttttgt     7920

tgtcgagctt ggtggcgaag gagccgtaga gggcgttgga gaggagcttg gcgatggagc     7980

gcatggtctg gtttttttcc ttgtcggcgc gctccttggc ggcgatgttg agctgcacgt     8040

actcgcgcgc cacgcacttc cattcgggga agacggtggt cagctcgtcg ggcacgattc     8100

tgacctgcca gccccgatta tgcagggtga tgaggtccac actggtggcc acctcgccgc     8160

gcaggggctc attagtccag cagaggcgtc cgcccttgcg cgagcagaag gggggcaggg     8220

ggtccagcat gacctcgtcg ggggggtcgg catcgatggt gaagatgccg ggcaggaggt     8280

cggggtcaaa gtagctgatg gaagtggcca gatcgtccag ggcagcttgc cattcgcgca     8340

cggccagcgc gcgctcgtag ggactgaggg gcgtgcccca gggcatggga tgggtaagcg     8400

cggaggcgta catgccgcag atgtcgtaga cgtagagggg ctcctcgagg atgccgatgt     8460

aggtggggta gcagcgcccc ccgcggatgc tggcgcgcac gtagtcatac agctcgtgcg     8520

agggggcgag gagccccggg cccaggttgg tgcgactggg cttttcggcg cggtagacga     8580

tctggcggaa aatggcatgc gagttggagg agatggtggg cctttggaag atgttgaagt     8640

gggcgtgggg cagtccgacc gagtcgcgga tgaagtgggc gtaggagtct tgcagcttgg     8700

cgacgagctc ggcggtgact aggacgtcca gagcgcagta gtcgagggtc tcctggatga     8760

tgtcatactt gagctgtccc ttttgtttcc acagctcgcg gttgagaagg aactcttcgc     8820

ggtccttcca gtactcttcg agggggaacc cgtcctgatc tgcacggtaa gagcctagca     8880

tgtagaactg gttgacggcc ttgtaggcgc agcagccctt ctccacgggg agggcgtagg     8940

cctgggcggc cttgcgcagg gaggtgtgcg tgagggcgaa agtgtccctg accatgacct     9000

tgaggaactg gtgcttgaag tcgatatcgt cgcagccccc ctgctcccag agctggaagt     9060

ccgtgcgctt cttgtaggcg gggttgggca aagcgaaagt aacatcgttg aagaggatct     9120

tgcccgcgcg gggcataaag ttgcgagtga tgcggaaagg ttggggcacc tcggcccggt     9180

tgttgatgac ctgggcggcg agcacgatct cgtcgaagcc gttgatgttg tggcccacga     9240

tgtagagttc cacgaatcgc ggacggccct tgacgtgggg cagtttcttg agctcctcgt     9300

aggtgagctc gtcggggtcg ctgagcccgt gctgctcgag cgcccagtcg gcgagatggg     9360

ggttggcgcg gaggaaggaa gtccagagat ccacggccag ggcggtttgc agacggtccc     9420

ggtactgacg gaactgctgc ccgacggcca ttttttcggg ggtgacgcag tagaaggtgc     9480

gggggtcccc gtgccagcga tcccatttga gctggagggc gagatcgagg gcgagctcga     9540

cgagccggtc gtccccggag agtttcatga ccagcatgaa ggggacgagc tgcttgccga     9600

aggaccccat ccaggtgtag gtttccacat cgtaggtgag gaagagcctt tcggtgcgag     9660

gatgcgagcc gatggggaag aactggatct cctgccacca attggaggaa tggctgttga     9720

tgtgatggaa gtagaaatgc cgacggcgcg ccgaacactc gtgcttgtgt ttatacaagc     9780

ggccacagtg ctcgcaacgc tgcacgggat gcacgtgctg cacgagctgt acctgagttc     9840

ctttgacgag gaatttcagt gggaagtgga gtcgtggcgc ctgcatctcg tgctgtacta     9900

cgtcgtggtg gtcggcctgg ccctcttctg cctcgatggt ggtcatgctg acgagcccgc     9960

gcgggaggca ggtccagacc tcggcgcgag cgggtcggag agcgaggacg agggcgcgca    10020

ggccggagct gtccagggtc ctgagacgct gcggagtcag gtcagtgggc agcggcggcg    10080

cgcggttgac ttgcaggagt ttttccaggg cgcgcgggag gtccagatgg tacttgatct    10140

ccaccgcgcc attggtggcg acgtcgatgg cttgcagggt cccgtgcccc tggggtgtga    10200

ccaccgtccc ccgtttcttc ttgggcggct ggggcgacgg gggcggtgcc tcttccatgg    10260

ttagaagcgg cggcgaggac gcgcgccggg cggcaggggc ggctcggggc ccggaggcag    10320

gggcggcagg ggcacgtcgg cgccgcgcgc gggtaggttc tggtactgcg cccggagaag    10380

actggcgtga gcgacgacgc gacggttgac gtcctggatc tgacgcctct gggtgaaggc    10440

cacgggaccc gtgagtttga acctgaaaga gagttcgaca gaatcaatct cggtatcgtt    10500

gacggcggcc tgccgcagga tctcttgcac gtcgcccgag ttgtcctggt aggcgatctc    10560

ggtcatgaac tgctcgatct cctcctcttg aaggtctccg cggccggcgc gctccacggt    10620

ggccgcgagg tcgttggaga tgcggcccat gagctgcgag aaggcgttca tgcccgcctc    10680

gttccagacg cggctgtaga ccacgacgcc ctcgggatcg cgggcgcgca tgaccacctg    10740

ggcgaggttg agctccacgt ggcgcgtgaa gaccgcgtag ttgcagaggc gctggtagag    10800

gtagttgagc gtggtggcga tgtgctcggt gacgaagaaa tacatgatcc agcggcggag    10860

cggcatctcg ctgacgtcgc ccagcgcctc caaacgttcc atggcctcgt aaaagtccac    10920

ggcgaagttg aaaaactggg agttgcgcgc cgagacggtc aactcctcct ccagaagacg    10980

gatgagctcg gcgatggtgg cgcgcacctc gcgctcgaag gcccccggga gttcctccac    11040

ttcctcttct tcctcctcca ctaacatctc ttctacttcc tcctcaggcg gcagtggtgg    11100

cgggggaggg ggcctgcgtc gccggcggcg cacgggcaga cggtcgatga agcgctcgat    11160

ggtctcgccg cgccggcgtc gcatggtctc ggtgacggcg cgcccgtcct cgcggggccg    11220

cagcgtgaag acgccgccgc gcatctccag gtggccgggg gggtccccgt tgggcaggga    11280

gagggcgctg acgatgcatc ttatcaattg ccccgtaggg actccgcgca aggacctgag    11340

cgtctcgaga tccacgggat ctgaaaaccg ctgaacgaag gcttcgagcc agtcgcagtc    11400

gcaaggtagg ctgagcacgg tttcttctgg cgggtcatgt tggttgggag cggggcgggc    11460

gatgctgctg gtgatgaagt tgaaataggc ggttctgaga cggcggatgg tggcgaggag    11520

caccaggtct ttgggcccgg cttgctggat gcgcagacgg tcggccatgc cccaggcgtg    11580

gtcctgacac ctggccaggt ccttgtagta gtcctgcatg agccgctcca cgggcacctc    11640

ctcctcgccc gcgcggccgt gcatgcgcgt gagcccgaag ccgcgctggg gctggacgag    11700

cgccaggtcg gcgacgacgc gctcggcgag gatggcttgc tggatctggg tgagggtggt    11760

ctggaagtca tcaaagtcga cgaagcggtg gtaggctccg gtgttgatgg tgtaggagca    11820

gttggccatg acggaccagt tgacggtctg gtggcccgga cgcacgagct cgtggtactt    11880

gaggcgcgag taggcgcgcg tgtcgaagat gtagtcgttg caggtgcgca ccaggtactg    11940

gtagccgatg aggaagtgcg gcggcggctg gcggtagagc ggccatcgct cggtggcggg    12000

ggcgccgggc gcgaggtcct cgagcatggt gcggtggtag ccgtagatgt acctggacat    12060

ccaggtgatg ccggcggcgg tggtggaggc gcgcgggaac tcgcggacgc ggttccagat    12120

gttgcgcagc ggcaggaagt agttcatggt gggcacggtc tggcccgtga ggcgcgcgca    12180

gtcgtggatg ctctatacgg gcaaaaacga aagcggtcag cggctcgact ccgtggcctg    12240

gaggctaagc gaacgggttg ggctgcgcgt gtaccccggt tcgaatctcg aatcaggctg    12300

gagccgcagc taacgtggta ttggcactcc cgtctcgacc caagcctgca ccaaccctcc    12360

aggatacgga ggcgggtcgt tttgcaactt ttttttggag gccggatgag actagtaagc    12420

gcggaaagcg gccgaccgcg atggctcgct gccgtagtct ggagaagaat cgccagggtt    12480

gcgttgcggt gtgccccggt tcgaggccgg ccggattccg cggctaacga gggcgtggct    12540

gccccgtcgt ttccaagacc ccatagccag ccgacttctc cagttacgga gcgagcccct    12600

cttttgtttt gtttgttttt gccagatgca tcccgtactg cggcagatgc gcccccacca    12660

ccctccaccg caacaacagc cccctccaca gccggcgctt ctgcccccgc cccagcagca    12720

acttccagcc acgaccgccg cggccgccgt gagcggggct ggacagagtt atgatcacca    12780

gctggccttg gaagagggcg aggggctggc gcgcctgggg gcgtcgtcgc cggagcggca    12840

cccgcgcgtg cagatgaaaa gggacgctcg cgaggcctac gtgcccaagc agaacctgtt    12900

cagagacagg agcggcgagg agcccgagga gatgcgcgcg gcccggttcc acgcggggcg    12960

ggagctgcgg cgcggcctgg accgaaagag ggtgctgagg gacgaggatt tcgaggcgga    13020

cgagctgacg gggatcagcc ccgcgcgcgc gcacgtggcc gcggccaacc tggtcacggc    13080

gtacgagcag accgtgaagg aggagagcaa cttccaaaaa tccttcaaca accacgtgcg    13140

caccctgatc gcgcgcgagg aggtgaccct gggcctgatg cacctgtggg acctgctgga    13200

ggccatcgtg cagaacccca ccagcaagcc gctgacggcg cagctgttcc tggtggtgca    13260

gcatagtcgg gacaacgaag cgttcaggga ggcgctgctg aatatcaccg agcccgaggg    13320

ccgctggctc ctggacctgg tgaacattct gcagagcatc gtggtgcagg agcgcgggct    13380

gccgctgtcc gagaagctgg cggccatcaa cttctcggtg ctgagtttgg gcaagtacta    13440

cgctaggaag atctacaaga ccccgtacgt gcccatagac aaggaggtga agatcgacgg    13500

gttttacatg cgcatgaccc tgaaagtgct gaccctgagc gacgatctgg gggtgtaccg    13560

caacgacagg atgcaccgtg cggtgagcgc cagcaggcgg cgcgagctga gcgaccagga    13620

gctgatgcat agtctgcagc gggccctgac cggggccggg accgaggggg agagctactt    13680

tgacatgggc gcggacctgc actggcagcc cagccgccgg gccttggagg cggcggcagg    13740

accctacgta gaagaggtgg acgatgaggt ggacgaggag ggcgagtacc tggaagactg    13800

atggcgcgac cgtatttttg ctagatgcaa caacaacagc cacctcctga tcccgcgatg    13860

cgggcggcgc tgcagagcca gccgtccggc attaactcct cggacgattg gacccaggcc    13920

atgcaacgca tcatggcgct gacgacccgc aaccccgaag cctttagaca gcagccccag    13980

gccaaccggc tctcggccat cctggaggcc gtggtgccct cgcgctccaa ccccacgcac    14040

gagaaggtcc tggccatcgt gaacgcgctg gtggagaaca aggccatccg cggcgacgag    14100

gccggcctgg tgtacaacgc gctgctggag cgcgtggccc gctacaacag caccaacgtg    14160

cagaccaacc tggaccgcat ggtgaccgac gtgcgcgagg ccgtggccca gcgcgagcgg    14220

ttccaccgcg agtccaacct gggatccatg gtggcgctga acgccttcct cagcacccag    14280

cccgccaacg tgccccgggg ccaggaggac tacaccaact tcatcagcgc cctgcgcctg    14340

atggtgaccg aggtgcccca gagcgaggtg taccagtccg ggccggacta cttcttccag    14400

accagtcgcc agggcttgca gaccgtgaac ctgagccagg ctttcaagaa cttgcagggc    14460

ctgtggggcg tgcaggcccc ggtcggggac cgcgcgacgg tgtcgagcct gctgacgccg    14520

aactcgcgcc tgctgctgct gctggtggcc cccttcacgg acagcggcag catcaaccgc    14580

aactcgtacc tgggctacct gattaacctg taccgcgagg ccatcggcca ggcgcacgtg    14640

gacgagcaga cctaccagga gatcacccac gtgagccgcg ccctgggcca ggacgacccg    14700

ggcaacctgg aagccaccct gaactttttg ctgaccaacc ggtcgcagaa gatcccgccc    14760

cagtacgcgc tcagcaccga ggaggagcgc atcctgcgtt acgtgcagca gagcgtgggc    14820

ctgttcctga tgcaggaggg ggccaccccc agcgccgcgc tcgacatgac cgcgcgcaac    14880

atggagccca gcatgtacgc cagcaaccgc ccgttcatca ataaactgat ggactacttg    14940

catcgggcgg ccgccatgaa ctctgactat ttcaccaacg ccatcctgaa tccccactgg    15000

ctcccgccgc cggggttcta cacgggcgag tacgacatgc ccgaccccaa tgacgggttc    15060

ctgtgggacg atgtggacag cagcgtgttc tccccccgac cgggtgctaa cgagcgcccc    15120

ttgtggaaga aggaaggcag cgaccgacgc ccgtcctcgg cgctgtccgg ccgcgagggt    15180

gctgccgcgg cggtgcccga ggccgccagt cctttcccga gcttgccctt ctcgctgaac    15240

agtatccgca gcagcgagct gggcaggatc acgcgcccgc gcttgctggg cgaagaggag    15300

tacttgaatg actcgctgtt gagacccgag cgggagaaga acttccccaa taacgggata    15360

gaaagcctgg tggacaagat gagccgctgg aagacgtatg cgcaggagca cagggacgat    15420

ccccgggcgt cgcagggggc cacgagccgg ggcagcgccg cccgtaaacg ccggtggcac    15480

gacaggcagc ggggacagat gtgggacgat gaggactccg ccgacgacag cagcgtgttg    15540

gacttgggtg ggagtggtaa cccgttcgct cacctgcgcc cccgtatcgg gcgcatgatg    15600

taagagaaac cgaaaataaa tgatactcac caaggccatg gcgaccagcg tgcgttcgtt    15660

tcttctctgt tgttgttgta tctagtatga tgaggcgtgc gtacccggag ggtcctcctc    15720

cctcgtacga gagcgtgatg cagcaggcga tggcggcggc ggcgatgcag cccccgctgg    15780

aggctcctta cgtgcccccg cggtacctgg cgcctacgga ggggcggaac agcattcgtt    15840

actcggagct ggcacccttg tacgatacca cccggttgta cctggtggac aacaagtcgg    15900

cggacatcgc ctcgctgaac taccagaacg accacagcaa cttcctgacc accgtggtgc    15960

agaacaatga cttcaccccc acggaggcca gcacccagac catcaacttt gacgagcgct    16020

cgcggtgggg cggccagctg aaaaccatca tgcacaccaa catgcccaac gtgaacgagt    16080

tcatgtacag caacaagttc aaggcgcggg tgatggtctc ccgcaagacc cccaatgggg    16140

tgacagtgac agaggattat gatggtagtc aggatgagct gaagtatgaa tgggtggaat    16200

ttgagctgcc cgaaggcaac ttctcggtga ccatgaccat cgacctgatg aacaacgcca    16260

tcatcgacaa ttacttggcg gtggggcggc agaacggggt gctggagagc gacatcggcg    16320

tgaagttcga cactaggaac ttcaggctgg gctgggaccc cgtgaccgag ctggtcatgc    16380

ccggggtgta caccaacgag gctttccatc ccgatattgt cttgctgccc ggctgcgggg    16440

tggacttcac cgagagccgc ctcagcaacc tgctgggcat tcgcaagagg cagcccttcc    16500

aggaaggctt ccagatcatg tacgaggatc tggagggggg caacatcccc gcgctcctgg    16560

atgtcgacgc ctatgagaaa agcaaggagg atgcagcagc tgaagcaact gcagccgtag    16620

ctaccgcctc taccgaggtc aggggcgata attttgcaag cgccgcagca gtggcagcgg    16680

ccgaggcggc tgaaaccgaa agtaagatag tcattcagcc ggtggagaag gatagcaaga    16740

acaggagcta caacgtacta ccggacaaga taaacaccgc ctaccgcagc tggtacctag    16800

cctacaacta tggcgacccc gagaagggcg tgcgctcctg gacgctgctc accacctcgg    16860

acgtcacctg cggcgtggag caagtctact ggtcgctgcc cgacatgatg caagacccgg    16920

tcaccttccg ctccacgcgt caagttagca actacccggt ggtgggcgcc gagctcctgc    16980

ccgtctactc caagagcttc ttcaacgagc aggccgtcta ctcgcagcag ctgcgcgcct    17040

tcacctcgct tacgcacgtc ttcaaccgct tccccgagaa ccagatcctc gtccgcccgc    17100

ccgcgcccac cattaccacc gtcagtgaaa acgttcctgc tctcacagat cacgggaccc    17160

tgccgctgcg cagcagtatc cggggagtcc agcgcgtgac cgttactgac gccagacgcc    17220

gcacctgccc ctacgtctac aaggccctgg gcatagtcgc gccgcgcgtc ctctcgagcc    17280

gcaccttcta aatgtccatt ctcatctcgc ccagtaataa caccggttgg ggcctgcgcg    17340

cgcccagcaa gatgtacgga ggcgctcgcc aacgctccac gcaacacccc gtgcgcgtgc    17400

gcgggcactt ccgcgctccc tggggcgccc tcaagggccg cgtgcggtcg cgcaccaccg    17460

tcgacgacgt gatcgaccag gtggtggccg acgcgcgcaa ctacaccccc gccgccgcgc    17520

ccgtctccac cgtggacgcc gtcatcgaca gcgtggtggc cgacgcgcgc cggtacgccc    17580

gcgccaagag ccggcggcgg cgcatcgccc ggcggcaccg gagcaccccc gccatgcgcg    17640

cggcgcgagc cttgctgcgc agggccaggc gcacgggacg cagggccatg ctcagggcgg    17700

ccagacgcgc ggcttcaggc gccagcgccg gcaggacccg gagacgcgcg gccacggcgg    17760

cggcagcggc catcgccagc atgtcccgcc cgcggcgagg gaacgtgtac tgggtgcgcg    17820

acgccgccac cggtgtgcgc gtgcccgtgc gcacccgccc ccctcgcact tgaagatgtt    17880

cacttcgcga tgttgatgtg tcccagcggc gaggaggatg tccaagcgca aattcaagga    17940

agagatgctc caggtcatcg cgcctgagat ctacggccct gcggtggtga aggaggaaag    18000

aaagccccgc aaaatcaagc gggtcaaaaa ggacaaaaag gaagaagaaa gtgatgtgga    18060

cggattggtg gagtttgtgc gcgagttcgc cccccggcgg cgcgtgcagt ggcgcgggcg    18120

gaaggtgcaa ccggtgctga gacccggcac caccgtggtc ttcacgcccg gcgagcgctc    18180

cggcaccgct tccaagcgct cctacgacga ggtgtacggg gatgatgata ttctggagca    18240

ggcggccgag cgcctgggcg agtttgctta cggcaagcgc agccgttccg caccgaagga    18300

agaggcggtg tccatcccgc tggaccacgg caaccccacg ccgagcctca agcccgtgac    18360

cttgcagcag gtgctgccga ccgcggcgcc gcgccggggg ttcaagcgcg agggcgagga    18420

tctgtacccc accatgcagc tgatggtgcc caagcgccag aagctggaag acgtgctgga    18480

gaccatgaag gtggacccgg acgtgcagcc cgaggtcaag gtgcggccca tcaagcaggt    18540

ggccccgggc ctgggcgtgc agaccgtgga catcaagatt cccacggagc ccatggaaac    18600

gcagaccgag cccatgatca agcccagcac cagcaccatg gaggtgcaga cggatccctg    18660

gatgccatcg gctcctagtc gaagaccccg gcgcaagtac ggcgcggcca gcctgctgat    18720

gcccaactac gcgctgcatc cttccatcat ccccacgccg ggctaccgcg gcacgcgctt    18780

ctaccgcggt cataccagca gccgccgccg caagaccacc actcgccgcc gccgtcgccg    18840

caccgccgct gcaaccaccc ctgccgccct ggtgcggaga gtgtaccgcc gcggccgcgc    18900

acctctgacc ctgccgcgcg cgcgctacca cccgagcatc gccatttaaa ctttcgcctg    18960

ctttgcagat caatggccct cacatgccgc cttcgcgttc ccattacggg ctaccgagga    19020

agaaaaccgc gccgtagaag gctggcgggg aacgggatgc gtcgccacca ccaccggcgg    19080

cggcgcgcca tcagcaagcg gttgggggga ggcttcctgc ccgcgctgat ccccatcatc    19140

gccgcggcga tcggggcgat ccccggcatt gcttccgtgg cggtgcaggc ctctcagcgc    19200

cactgagaca cacttggaaa catcttgtaa taaaccaatg gactctgacg ctcctggtcc    19260

tgtgatgtgt tttcgtagac agatggaaga catcaatttt tcgtccctgg ctccgcgaca    19320

cggcacgcgg ccgttcatgg gcacctggag cgacatcggc accagccaac tgaacggggg    19380

cgccttcaat tggagcagtc tctggagcgg gcttaagaat ttcgggtcca cgcttaaaac    19440

ctatggcagc aaggcgtgga acagcaccac agggcaggcg ctgagggata agctgaaaga    19500

gcagaacttc cagcagaagg tggtcgatgg gctcgcctcg ggcatcaacg gggtggtgga    19560

cctggccaac caggccgtgc agcggcagat caacagccgc ctggacccgg tgccgcccgc    19620

cggctccgtg gagatgccgc aggtggagga ggagctgcct cccctggaca agcggggcga    19680

gaagcgaccc cgccccgatg cggaggagac gctgctgacg cacacggacg agccgccccc    19740

gtacgaggag gcggtgaaac tgggtctgcc caccacgcgg cccatcgcgc ccctggccac    19800

cggggtgctg aaacccgaaa agcccgcgac cctggacttg cctcctcccc agccttcccg    19860

cccctctaca gtggctaagc ccctgccgcc ggtggccgtg gcccgcgcgc gacccggggg    19920

caccgcccgc cctcatgcga actggcagag cactctgaac agcatcgtgg gtctgggagt    19980

gcagagtgtg aagcgccgcc gctgctatta aacctaccgt agcgcttaac ttgcttgtct    20040

gtgtgtgtat gtattatgtc gccgccgccg ctgtccacca gaaggaggag tgaagaggcg    20100

cgtcgccgag ttgcaagatg gccaccccat cgatgctgcc ccagtgggcg tacatgcaca    20160

tcgccggaca ggacgcttcg gagtacctga gtccgggtct ggtgcagttt gcccgcgcca    20220

cagacaccta cttcagtctg gggaacaagt ttaggaaccc cacggtggcg cccacgcacg    20280

atgtgaccac cgaccgcagc cagcggctga cgctgcgctt cgtgcccgtg gaccgcgagg    20340

acaacaccta ctcgtacaaa gtgcgctaca cgctggccgt gggcgacaac cgcgtgctgg    20400

acatggccag cacctacttt gacatccgcg gcgtgctgga tcggggccct agcttcaaac    20460

cctactccgg caccgcctac aacagtctgg cccccaaggg agcacccaac acttgtcagt    20520

ggacatataa agccgatggt gaaactgcca cagaaaaaac ctatacatat ggaaatgcac    20580

ccgtgcaggg cattaacatc acaaaagatg gtattcaact tggaactgac accgatgatc    20640

agccaatcta cgcagataaa acctatcagc ctgaacctca agtgggtgat gctgaatggc    20700

atgacatcac tggtactgat gaaaagtatg gaggcagagc tcttaagcct gataccaaaa    20760

tgaagccttg ttatggttct tttgccaagc ctactaataa agaaggaggt caggcaaatg    20820

tgaaaacagg aacaggcact actaaagaat atgacataga catggctttc tttgacaaca    20880

gaagtgcggc tgctgctggc ctagctccag aaattgtttt gtatactgaa aatgtggatt    20940

tggaaactcc agatacccat attgtataca aagcaggcac agatgacagc agctcttcta    21000

ttaatttggg tcagcaagcc atgcccaaca gacctaacta cattggtttc agagacaact    21060

ttatcgggct catgtactac aacagcactg gcaatatggg ggtgctggcc ggtcaggctt    21120

ctcagctgaa tgctgtggtt gacttgcaag acagaaacac cgagctgtcc taccagctct    21180

tgcttgactc tctgggtgac agaacccggt atttcagtat gtggaatcag gcggtggaca    21240

gctatgatcc tgatgtgcgc attattgaaa atcatggtgt ggaggatgaa cttcccaact    21300

attgtttccc tctggatgct gttggcagaa cagatactta tcagggaatt aaggctaatg    21360

gaactgatca aaccacatgg accaaagatg acagtgtcaa tgatgctaat gagataggca    21420

agggtaatcc attcgccatg gaaatcaaca tccaagccaa cctgtggagg aacttcctct    21480

acgccaacgt ggccctgtac ctgcccgact cttacaagta cacgccggcc aatgttaccc    21540

tgcccaccaa caccaacacc tacgattaca tgaacggccg ggtggtggcg ccctcgctgg    21600

tggactccta catcaacatc ggggcgcgct ggtcgctgga tcccatggac aacgtgaacc    21660

ccttcaacca ccaccgcaat gcggggctgc gctaccgctc catgctcctg ggcaacgggc    21720

gctacgtgcc cttccacatc caggtgcccc agaaattttt cgccatcaag agcctcctgc    21780

tcctgcccgg gtcctacacc tacgagtgga acttccgcaa ggacgtcaac atgatcctgc    21840

agagctccct cggcaacgac ctgcgcacgg acggggcctc catctccttc accagcatca    21900

acctctacgc caccttcttc cccatggcgc acaacacggc ctccacgctc gaggccatgc    21960

tgcgcaacga caccaacgac cagtccttca acgactacct ctcggcggcc aacatgctct    22020

accccatccc ggccaacgcc accaacgtgc ccatctccat cccctcgcgc aactgggccg    22080

ccttccgcgg ctggtccttc acgcgtctca agaccaagga gacgccctcg ctgggctccg    22140

ggttcgaccc ctacttcgtc tactcgggct ccatccccta cctcgacggc accttctacc    22200

tcaaccacac cttcaagaag gtctccatca ccttcgactc ctccgtcagc tggcccggca    22260

acgaccggct cctgacgccc aacgagttcg aaatcaagcg caccgtcgac ggcgagggct    22320

acaacgtggc ccagtgcaac atgaccaagg actggttcct ggtccagatg ctggcccact    22380

acaacatcgg ctaccagggc ttctacgtgc ccgagggcta caaggaccgc atgtactcct    22440

tcttccgcaa cttccagccc atgagccgcc aggtggtgga cgaggtcaac tacaaggact    22500

accaggccgt caccctggcc taccagcaca acaactcggg cttcgtcggc tacctcgcgc    22560

ccaccatgcg ccagggccag ccctaccccg ccaactaccc ctacccgctc atcggcaaga    22620

gcgccgtcac cagcgtcacc cagaaaaagt tcctctgcga cagggtcatg tggcgcatcc    22680

ccttctccag caacttcatg tccatgggcg cgctcaccga cctcggccag aacatgctct    22740

atgccaactc cgcccacgcg ctagacatga atttcgaagt cgaccccatg gatgagtcca    22800

cccttctcta tgttgtcttc gaagtcttcg acgtcgtccg agtgcaccag ccccaccgcg    22860

gcgtcatcga ggccgtctac ctgcgcaccc ccttctcggc cggtaacgcc accacctaag    22920

ctcttgcttc ttgcaagcca tggccgcggg ctccggcgag caggagctca gggccatcat    22980

ccgcgacctg ggctgcgggc cctacttcct gggcaccttc gataagcgct tcccgggatt    23040

catggccccg cacaagctgg cctgcgccat cgtcaacacg gccggccgcg agaccggggg    23100

cgagcactgg ctggccttcg cctggaaccc gcgctcgaac acctgctacc tcttcgaccc    23160

cttcgggttc tcggacgagc gcctcaagca gatctaccag ttcgagtacg agggcctgct    23220

gcgccgcagc gccctggcca ccgaggaccg ctgcgtcacc ctggaaaagt ccacccagac    23280

cgtgcagggt ccgcgctcgg ccgcctgcgg gctcttctgc tgcatgttcc tgcacgcctt    23340

cgtgcactgg cccgaccgcc ccatggacaa gaaccccacc atgaacttgc tgacgggggt    23400

gcccaacggc atgctccagt cgccccaggt ggaacccacc ctgcgccgca accaggaggc    23460

gctctaccgc ttcctcaact cccactccgc ctactttcgc tcccaccgcg cgcgcatcga    23520

gaaggccacc gccttcgacc gcatgaatca agacatgtaa accgtgtgtg tatgttaaat    23580

gtctttaata aacagcactt tcatgttaca catgcatctg agatgattta tttagaaatc    23640

gaaagggttc tgccgggtct cggcatggcc cgcgggcagg gacacgttgc ggaactggta    23700

cttggccagc cacttgaact cggggatcag cagtttgggc agcggggtgt cggggaagga    23760

gtcggtccac agcttccgcg tcagttgcag ggcgcccagc aggtcgggcg cggagatctt    23820

gaaatcgcag ttgggacccg cgttctgcgc gcgggagttg cggtacacgg ggttgcagca    23880

ctggaacacc atcagggccg ggtgcttcac gctcgccagc accgtcgcgt cggtgatgct    23940

ctccacgtcg aggtcctcgg cgttggccat cccgaagggg gtcatcttgc aggtctgcct    24000

tcccatggtg ggcacgcacc cgggcttgtg gttgcaatcg cagtgcaggg ggatcagcat    24060

catctgggcc tggtcggcgt tcatccccgg gtacatggcc ttcatgaaag cctccaattg    24120

cctgaacgcc tgctgggcct tggctccctc ggtgaagaag accccgcagg acttgctaga    24180

gaactggttg gtggcgcacc cggcgtcgtg cacgcagcag cgcgcgtcgt tgttggccag    24240

ctgcaccacg ctgcgccccc agcggttctg ggtgatcttg gcccggtcgg ggttctcctt    24300

cagcgcgcgc tgcccgttct cgctcgccac atccatctcg atcatgtgct ccttctggat    24360

catggtggtc ccgtgcaggc accgcagctt gccctcggcc tcggtgcacc cgtgcagcca    24420

cagcgcgcac ccggtgcact cccagttctt gtgggcgatc tgggaatgcg cgtgcacgaa    24480

gccctgcagg aagcggccca tcatggtggt cagggtcttg ttgctagtga aggtcagcgg    24540

aatgccgcgg tgctcctcgt tgatgtacag gtggcagatg cggcggtaca cctcgccctg    24600

ctcgggcatc agctggaagt tggctttcag gtcggtctcc acgcggtagc ggtccatcag    24660

catagtcatg atttccatac ccttctccca ggccgagacg atgggcaggc tcatagggtt    24720

cttcaccatc atcttagcgc tagcagccgc ggccaggggg tcgctctcgt ccagggtctc    24780

aaagctccgc ttgccgtcct tctcggtgat ccgcaccggg gggtagctga agcccacggc    24840

cgccagctcc tcctcggcct gtctttcgtc ctcgctgtcc tggctgacgt cctgcaggac    24900

cacatgcttg gtcttgcggg gtttcttctt gggcggcagc ggcggcggag atgttggaga    24960

tggcgagggg gagcgcgagt tctcgctcac cactactatc tcttcctctt cttggtccga    25020

ggccacgcgg cggtaggtat gtctcttcgg gggcagaggc ggaggcgacg ggctctcgcc    25080

gccgcgactt ggcggatggc tggcagagcc ccttccgcgt tcgggggtgc gctcccggcg    25140

gcgctctgac tgacttcctc cgcggccggc cattgtgttc tcctagggag gaacaacaag    25200

catggagact cagccatcgc caacctcgcc atctgccccc accgccgacg agaagcagca    25260

gcagcagaat gaaagcttaa ccgccccgcc gcccagcccc gccacctccg acgcggccgt    25320

cccagacatg caagagatgg aggaatccat cgagattgac ctgggctatg tgacgcccgc    25380

ggagcacgag gaggagctgg cagtgcgctt ttcacaagaa gagatacacc aagaacagcc    25440

agagcaggaa gcagagaatg agcagagtca ggctgggctc gagcatgacg gcgactacct    25500

ccacctgagc gggggggagg acgcgctcat caagcatctg gcccggcagg ccaccatcgt    25560

caaggatgcg ctgctcgacc gcaccgaggt gcccctcagc gtggaggagc tcagccgcgc    25620

ctacgagttg aacctcttct cgccgcgcgt gccccccaag cgccagccca atggcacctg    25680

cgagcccaac ccgcgcctca acttctaccc ggtcttcgcg gtgcccgagg ccctggccac    25740

ctaccacatc tttttcaaga accaaaagat ccccgtctcc tgccgcgcca accgcacccg    25800

cgccgacgcc cttttcaacc tgggtcccgg cgcccgccta cctgatatcg cctccttgga    25860

agaggttccc aagatcttcg agggtctggg cagcgacgag actcgggccg cgaacgctct    25920

gcaaggagaa ggaggagagc atgagcacca cagcgccctg gtcgagttgg aaggcgacaa    25980

cgcgcggctg gcggtgctca aacgcacggt cgagctgacc catttcgcct acccggctct    26040

gaacctgccc cccaaagtca tgagcgcggt catggaccag gtgctcatca agcgcgcgtc    26100

gcccatctcc gaggacgagg gcatgcaaga ctccgaggag ggcaagcccg tggtcagcga    26160

cgagcagctg gcccggtggc tgggtcctaa tgctagtccc cagagtttgg aagagcggcg    26220

caaactcatg atggccgtgg tcctggtgac cgtggagctg gagtgcctgc gccgcttctt    26280

cgccgacgcg gagaccctgc gcaaggtcga ggagaacctg cactacctct tcaggcacgg    26340

gttcgtgcgc caggcctgca agatctccaa cgtggagctg accaacctgg tctcctacat    26400

gggcatcttg cacgagaacc gcctggggca gaacgtgctg cacaccaccc tgcgcgggga    26460

ggcccggcgc gactacatcc gcgactgcgt ctacctctac ctctgccaca cctggcagac    26520

gggcatgggc gtgtggcagc agtgtctgga ggagcagaac ctgaaagagc tctgcaagct    26580

cctgcagaag aacctcaagg gtctgtggac cgggttcgac gagcgcacca ccgcctcgga    26640

cctggccgac ctcattttcc ccgagcgcct caggctgacg ctgcgcaacg gcctgcccga    26700

ctttatgagc caaagcatgt tgcaaaactt tcgctctttc atcctcgaac gctccggaat    26760

cctgcccgcc acctgctccg cgctgccctc ggacttcgtg ccgctgacct tccgcgagtg    26820

ccccccgccg ctgtggagcc actgctacct gctgcgcctg gccaactacc tggcctacca    26880

ctcggacgtg atcgaggacg tcagcggcga gggcctgctc gagtgccact gccgctgcaa    26940

cctctgcacg ccgcaccgct ccctggcctg caacccccag ctgctgagcg agacccagat    27000

catcggcacc ttcgagttgc aagggcccag cgaaggcgag ggttcagccg ccaagggggg    27060

tctgaaactc accccggggc tgtggacctc ggcctacttg cgcaagttcg tgcccgagga    27120

ctaccatccc ttcgagatca ggttctacga ggaccaatcc catccgccca aggccgagct    27180

gtcggcctgc gtcatcaccc agggggcgat cctggcccaa ttgcaagcca tccagaaatc    27240

ccgccaagaa ttcttgctga aaaagggccg cggggtctac ctcgaccccc agaccggtga    27300

ggagctcaac cccggcttcc cccaggatgc cccgaggaaa caagaagctg aaagtggagc    27360

tgccgcccgt ggaggatttg gaggaagact gggagaacag cagtcaggca gaggaggagg    27420

agatggagga agactgggac agcactcagg cagaggagga cagcctgcaa gacagtctgg    27480

aggaagacga ggaggaggca gaggaggagg tggaagaagc agccgccgcc agaccgtcgt    27540

cctcggcggg ggagaaagca agcagcacgg ataccatctc cgctccgggt cggggtcccg    27600

ctcgaccaca cagtagatgg gacgagaccg gacgattccc gaaccccacc acccagaccg    27660

gtaagaagga gcggcaggga tacaagtcct ggcgggggca caaaaacgcc atcgtctcct    27720

gcttgcaggc ctgcgggggc aacatctcct tcacccggcg ctacctgctc ttccaccgcg    27780

gggtgaactt tccccgcaac atcttgcatt actaccgtca cctccacagc ccctactact    27840

tccaagaaga ggcagcagca gcagaaaaag accagcagaa aaccagcagc tagaaaatcc    27900

acagcggcgg cagcaggtgg actgaggatc gcggcgaacg agccggcgca aacccgggag    27960

ctgaggaacc ggatctttcc caccctctat gccatcttcc agcagagtcg ggggcaggag    28020

caggaactga aagtcaagaa ccgttctctg cgctcgctca cccgcagttg tctgtatcac    28080

aagagcgaag accaacttca gcgcactctc gaggacgccg aggctctctt caacaagtac    28140

tgcgcgctca ctcttaaaga gtagcccgcg cccgcccagt cgcagaaaaa ggcgggaatt    28200

acgtcacctg tgcccttcgc cctagccgcc tccacccatc atcatgagca aagagattcc    28260

cacgccttac atgtggagct accagcccca gatgggcctg gccgccggtg ccgcccagga    28320

ctactccacc cgcatgaatt ggctcagcgc cgggcccgcg atgatctcac gggtgaatga    28380

catccgcgcc caccgaaacc agatactcct agaacagtca gcgctcaccg ccacgccccg    28440

caatcacctc aatccgcgta attggcccgc cgccctggtg taccaggaaa ttccccagcc    28500

cacgaccgta ctacttccgc gagacgccca ggccgaagtc cagctgacta actcaggtgt    28560

ccagctggcg ggcggcgcca ccctgtgtcg tcaccgcccc gctcagggta taaagcggct    28620

ggtgatccgg ggcagaggca cacagctcaa cgacgaggtg gtgagctctt cgctgggtct    28680

gcgacctgac ggagtcttcc aactcgccgg atcggggaga tcttccttca cgcctcgtca    28740

ggccgtcctg actttggaga gttcgtcctc gcagccccgc tcgggtggca tcggcactct    28800

ccagttcgtg gaggagttca ctccctcggt ctacttcaac cccttctccg gctcccccgg    28860

ccactacccg gacgagttca tcccgaactt cgacgccatc agcgagtcgg tggacggcta    28920

cgattgaatg tcccatggtg gcgcagctga cctagctcgg cttcgacacc tggaccactg    28980

ccgccgcttc cgctgcttcg ctcgggatct cgccgagttt gcctactttg agctgcccga    29040

ggagcaccct cagggcccgg cccacggagt gcggatcgtc gtcgaagggg gcctcgactc    29100

ccacctgctt cggatcttca gccagcgtcc gatcctggtc gagcgcgagc aaggacagac    29160

ccttctgact ctgtactgca tctgcaacca ccccggcctg catgaaagtc tttgttgtct    29220

gctgtgtact gagtataata aaagctgaga tcagcgacta ctccggactt ccgtgtgttc    29280

ctgaatccat caaccagtct ttgttcttca ccgggaacga gaccgagctc cagctccagt    29340

gtaagcccca caagaagtac ctcacctggc tgttccaggg ctccccgatc gccgttgtca    29400

accactgcga caacgacgga gtcctgctga gcggccctgc caaccttact ttttccaccc    29460

gcagaagcaa gctccagctc ttccaaccct tcctccccgg gacctatcag tgcgtctcgg    29520

gaccctgcca tcacaccttc cacctgatcc cgaataccac agcgtcgctc cccgctacta    29580

acaaccaaac taacctccac caacgccacc gtcgctaggc cacaatacat gcccatatta    29640

gactatgagg ccgagccaca gcgacccatg ctccccgcta ttagttactt caatctaacc    29700

ggcggagatg actgacccac tggccaacaa caacgtcaac gaccttctcc tggacatgga    29760

cggccgcgcc tcggagcagc gactcgccca acttcgcatt cgccagcagc aggagagagc    29820

cgtcaaggag ctgcaggatg cggtggccat ccaccagtgc aagagaggca tcttctgcct    29880

ggtgaaacag gccaagatct cctacgaggt cactccaaac gaccatcgcc tctcctacga    29940

gctcctgcag cagcgccaga agttcacctg cctggtcgga gtcaacccca tcgtcatcac    30000

ccagcagtct ggcgatacca aggggtgcat ccactgctcc tgcgactccc ccgactgcgt    30060

ccacactctg atcaagaccc tctgcggcct ccgcgacctc ctccccatga actaatcacc    30120

cccttatcca gtgaaataaa gatcatattg atgatgattt tacagaaata aaaaataatc    30180

atttgatttg aaataaagat acaatcatat tgatgatttg agtttaacaa aaaaataaag    30240

aatcacttac ttgaaatctg ataccaggtc tctgtccatg ttttctgcca acaccacttc    30300

actcccctct tcccagctct ggtactgcag gccccggcgg gctgcaaact tcctccacac    30360

gctgaagggg atgtcaaatt cctcctgtcc ctcaatcttc attttatctt ctatcagatg    30420

tccaaaaagc gcgtccgggt ggatgatgac ttcgaccccg tctaccccta cgatgcagac    30480

aacgcaccga ccgtgccctt catcaacccc cccttcgtct cttcagatgg attccaagag    30540

aagcccctgg gggtgttgtc cctgcgactg gccgaccccg tcaccaccaa gaacggggaa    30600

atcaccctca agctgggaga gggggtggac ctcgattcct cgggaaaact catctccaac    30660

acggccacca aggccgccgc ccctctcagt ttttccaaca acaccatttc ccttaacatg    30720

gatcacccct tttacactaa agatggaaaa ttatccttac aagtttctcc accattaaat    30780

atactgagaa caagcattct aaacacacta gctttaggtt ttggatcagg tttaggactc    30840

cgtggctctg ccttggcagt acagttagtc tctccactta catttgatac tgatggaaac    30900

ataaagctta ccttagacag aggtttgcat gttacaacag gagatgcaat tgaaagcaac    30960

ataagctggg ctaaaggttt aaaatttgaa gatggagcca tagcaaccaa cattggaaat    31020

gggttagagt ttggaagcag tagtacagaa acaggtgttg atgatgctta cccaatccaa    31080

gttaaacttg gatctggcct tagctttgac agtacaggag ccataatggc tggtaacaaa    31140

gaagacgata aactcacttt gtggacaaca cctgatccat caccaaactg tcaaatactc    31200

gcagaaaatg atgcaaaact aacactttgc ttgactaaat gtggtagtca aatactggcc    31260

actgtgtcag tcttagttgt aggaagtgga aacctaaacc ccattactgg caccgtaagc    31320

agtgctcagg tgtttctacg ttttgatgca aacggtgttc ttttaacaga acattctaca    31380

ctaaaaaaat actgggggta taggcaggga gatagcatag atggcactcc atataccaat    31440

gctgtaggat tcatgcccaa tttaaaagct tatccaaagt cacaaagttc tactactaaa    31500

aataatatag tagggcaagt atacatgaat ggagatgttt caaaacctat gcttctcact    31560

ataaccctca atggtactga tgacagcaac agtacatatt caatgtcatt ttcatacacc    31620

tggactaatg gaagctatgt tggagcaaca tttggggcta actcttatac cttctcatac    31680

atcgcccaag aatgaacact gtatcccacc ctgcatgcca acccttccca ccccactctg    31740

tggaacaaac tctgaaacac aaaataaaat aaagttcaag tgttttattg attcaacagt    31800

tttacaggat tcgagcagtt atttttcctc caccctccca ggacatggaa tacaccaccc    31860

tctccccccg cacagccttg aacatctgaa tgccattggt gatggacatg cttttggtct    31920

ccacgttcca cacagtttca gagcgagcca gtctcgggtc ggtcagggag atgaaaccct    31980

ccgggcactc ccgcatctgc acctcacagc tcaacagctg aggattgtcc tcggtggtcg    32040

ggatcacggt tatctggaag aagcagaaga gcggcggtgg gaatcatagt ccgcgaacgg    32100

gatcggccgg tggtgtcgca tcaggccccg cagcagtcgc tgccgccgcc gctccgtcaa    32160

gctgctgctc agggggtccg ggtccaggga ctccctcagc atgatgccca cggccctcag    32220

catcagtcgt ctggtgcggc gggcgcagca gcgcatgcgg atctcgctca ggtcgctgca    32280

gtacgtgcaa cacagaacca ccaggttgtt caacagtcca tagttcaaca cgctccagcc    32340

gaaactcatc gcgggaagga tgctacccac gtggccgtcg taccagatcc tcaggtaaat    32400

caagtggtgc cccctccaga acacgctgcc cacgtacatg atctccttgg gcatgtggcg    32460

gttcaccacc tcccggtacc acatcaccct ctggttgaac atgcagcccc ggatgatcct    32520

gcggaaccac agggccagca ccgccccgcc cgccatgcag cgaagagacc ccgggtcccg    32580

gcaatggcaa tggaggaccc accgctcgta cccgtggatc atctgggagc tgaacaagtc    32640

tatgttggca cagcacaggc atatgctcat gcatctcttc agcactctca actcctcggg    32700

ggtcaaaacc atatcccagg gcacggggaa ctcttgcagg acagcgaacc ccgcagaaca    32760

gggcaatcct cgcacagaac ttacattgtg catggacagg gtatcgcaat caggcagcac    32820

cgggtgatcc tccaccagag aagcgcgggt ctcggtctcc tcacagcgtg gtaagggggc    32880

cggccgatac gggtgatggc gggacgcggc tgatcgtgtt cgcgaccgtg tcatgatgca    32940

gttgctttcg gacattttcg tacttgctgt agcagaacct ggtccgggcg ctgcacaccg    33000

atcgccggcg gcggtctcgg cgcttggaac gctcggtgtt gaaattgtaa aacagccact    33060

ctctcagacc gtgcagcaga tctagggcct caggagtgat gaagatccca tcatgcctga    33120

tggctctgat cacatcgacc accgtggaat gggccagacc cagccagatg atgcaatttt    33180

gttgggtttc ggtgacggcg ggggagggaa gaacaggaag aaccatgatt aacttttaat    33240

ccaaacggtc tcggagtact tcaaaatgaa gatcgcggag atggcacctc tcgcccccgc    33300

tgtgttggtg gaaaataaca gccaggtcaa aggtgatacg gttctcgaga tgttccacgg    33360

tggcttccag caaagcctcc acgcgcacat ccagaaacaa gacaatagcg aaagcgggag    33420

ggttctctaa ttcctcaatc atcatgttac actcctgcac catccccaga taattttcat    33480

ttttccagcc ttgaatgatt cgaactagtt cctgaggtaa atccaagcca gccatgataa    33540

agagctcgcg cagagcgccc tccaccggca ttcttaagca caccctcata attccaagat    33600

attctgctcc tggttcacct gcagcagatt gacaagcgga atatcaaaat ctctgccgcg    33660

atccctgagc tcctccctca gcaataactg taagtactct ttcatatcct ctccgaaatt    33720

tttagccata ggaccaccag gaataagatt agggcaagcc acagtacaga taaaccgaag    33780

tcctccccag tgagcattgc caaatgcaag actgctataa gcatgctggc tagacccggt    33840

gatatcttcc agataactgg acagaaaatc gcccaggcaa tttttaagaa aatcaacaaa    33900

agaaaaatcc tccaggtgga cgtttagagc ctcgggaaca acgatgaagt aaatgcaagc    33960

ggtgcgttcc agcatggtta gttagctgat ctgtagaaaa aacaaaaatg aacattaaac    34020

catgctagcc tggcgaacag gtgggtaaat cgttctctcc agcaccaggc aggccacggg    34080

gtctccggcg cgaccctcgt aaaaattgtc gctatgattg aaaaccatca cagagagacg    34140

ttcccggtgg ccggcgtgaa tgattcgaca agatgaatac acccccggaa cattggcgtc    34200

cgcgagtgaa aaaaagcgcc cgaggaagca ataaggcact acaatgctca gtctcaagtc    34260

cagcaaagcg atgccatgcg gatgaagcac aaaattctca ggtgcgtaca aaatgtaatt    34320

actcccctcc tgcacaggca gcaaagcccc cgatccctcc aggtacacat acaaagcctc    34380

agcgtccata gcttaccgag cagcagcaca caacaggcgc aagagtcaga gaaaggctga    34440

gctctaacct gtccacccgc tctctgctca atatatagcc cagatctaca ctgacgtaaa    34500

ggccaaagtc taaaaatacc cgccaaataa tcacacacgc ccagcacacg cccagaaacc    34560

ggtgacacac tcaaaaaaat acgcgcactt cctcaaacgc ccaaaactgc cgtcatttcc    34620

gggttcccac gctacgtcat caaaacacga ctttcaaatt ccgtcgaccg ttaaaaacgt    34680

cacccgcccc gcccctaacg gtcgcccgtc tctcagccaa tcagcgcccc gcatccccaa    34740

attcaaacac ctcatttgca tattaacgcg cacaaaaagt ttgaggtata ttattgatga    34800

tgg                                                                  34803


<210>  46
<211>  7182
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46
ggcgtaatgc tctgccagtg ttacaaccaa ttaaccaatt ctgattagaa aaactcatcg       60

agcatcaaat gaaactgcaa tttattcata tcaggattat caataccata tttttgaaaa      120

agccgtttct gtaatgaagg agaaaactca ccgaggcagt tccataggat ggcaagatcc      180

tggtatcggt ctgcgattcc gactcgtcca acatcaatac aacctattaa tttcccctcg      240

tcaaaaataa ggttatcaag tgagaaatca ccatgagtga cgactgaatc cggtgagaat      300

ggcaaaagct tatgcatttc tttccagact tgttcaacag gccagccatt acgctcgtca      360

tcaaaatcac tcgcatcaac caaaccgtta ttcattcgtg attgcgcctg agcgagacga      420

aatacgcgat cgctgttaaa aggacaatta caaacaggaa tcaaatgcaa ccggcgcagg      480

aacactgcca gcgcatcaac aatattttca cctgaatcag gatattcttc taatacctgg      540

aatgctgttt tcccggggat cgcagtggtg agtaaccatg catcatcagg agtacggata      600

aaatgcttga tggtcggaag aggcataaat tccgtcagcc agtttagtct gaccatctca      660

tctgtaacat cattggcaac gctacctttg ccatgtttca gaaacaactc tggcgcatcg      720

ggcttcccat acaatcgata gattgtcgca cctgattgcc cgacattatc gcgagcccat      780

ttatacccat ataaatcagc atccatgttg gaatttaatc gcggcctcga gcaagacgtt      840

tcccgttgaa tatggctcat aacacccctt gtattactgt ttatgtaagc agacaggtcg      900

acaatattgg ctattggcca ttgcatacgt tgtatctata tcataatatg tacatttata      960

ttggctcatg tccaatatga ccgccatgtt gacattgatt attgactagt tattaatagt     1020

aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta     1080

cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga     1140

cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt     1200

tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt ccgcccccta     1260

ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttacggg     1320

actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt     1380

tttggcagta caccaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc     1440

accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat     1500

gtcgtaataa ccccgccccg ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct     1560

atataagcag agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt     1620

ttgacctcca tagaagacac cgggaccgat ccagcctccg cggccgggaa cggtgcattg     1680

gaacgcggat tccccgtgcc aagagtgact caccgtccgg atctcagcaa gcaggtatgt     1740

actctccagg gtgggcctgg cttccccagt caagactcca gggatttgag ggacgctgtg     1800

ggctcttctc ttacatgtac cttttgcttg cctcaaccct gactatcttc caggtcagga     1860

tcccagagtc aggggtctgt attttcctgc tggtggctcc agttcaggaa cagtaaaccc     1920

tgctccgaat attgcctctc acatctcgtc aatctccgcg aggactgggg accctgtgac     1980

gaacatggct agcattgtgg gaggctggga gtgcgagaag cattcccaac cctggcaggt     2040

gcttgtggcc tctcgtggca gggcagtctg cggcggtgtt ctggtgcacc cccagtgggt     2100

cctcacagct gcccactgca tcaggaacaa aagcgtgatc ttgctgggtc ggcacagctt     2160

gtttcatcct gaagacacag gccaggtatt tcaggtcagc cacagcttcc cacacccgct     2220

ctacgatatg agcctcctga agaatcgatt cctcaggcca ggtgatgact ccagccacga     2280

cctcatgctg ctccgcctgt cagagcctgc cgagctcacg gatgctgtga aggtcatgga     2340

cctgcccacc caggagccag cactggggac cacctgctac gcctcaggct ggggcagcat     2400

tgaaccagag gagttcttga ccccaaagaa acttcagtgt gtggacctcc atgttatttc     2460

caatgacgtg tgtgcgcaag ttcaccctca gaaggtgacc aagttcatgc tgtgtgctgg     2520

acgctggaca gggggcaaaa gcacctgctc gggtgattct gggggcccac ttgtctgtaa     2580

tggtgtgctt caaggtatca cgtcatgggg cagtgaacca tgtgccctgc ccgaaaggcc     2640

ttccctgtac accaaggtgg tgcattaccg gaagtggatc aaggacacca tcgtggccaa     2700

ccccggatcc gaaggtaggg gttcattatt gacctgtgga gatgtcgaag aaaacccagg     2760

acccgctagc aaggctgtgc tgcttgccct gttgatggca ggcttggccc tgcagccagg     2820

cactgccctg ctgtgctact cctgcaaagc ccaggtgagc aacgaggact gcctgcaggt     2880

ggagaactgc acccagctgg gggagcagtg ctggaccgcg cgcatccgcg cagttggcct     2940

cctgaccgtc atcagcaaag gctgcagctt gaactgcgtg gatgactcac aggactacta     3000

cgtgggcaag aagaacatca cgtgctgtga caccgacttg tgcaacgcca gcggggccca     3060

tgccctgcag ccggctgccg ccatccttgc gctgctccct gcactcggcc tgctgctctg     3120

gggacccggc cagctaggat cccagaccct gaactttgat ctgctgaaac tggcaggcga     3180

tgtggaaagc aacccaggcc caatggcaag cgcgcgccgc ccgcgctggc tgtgcgctgg     3240

ggcgctggtg ctggcgggtg gcttctttct cctcggcttc ctcttcgggt ggtttataaa     3300

atcctccaat gaagctacta acattactcc aaagcataat atgaaagcat ttttggatga     3360

attgaaagct gagaacatca agaagttctt atataatttt acacagatac cacatttagc     3420

aggaacagaa caaaactttc agcttgcaaa gcaaattcaa tcccagtgga aagaatttgg     3480

cctggattct gttgagctgg cacattatga tgtcctgttg tcctacccaa ataagactca     3540

tcccaactac atctcaataa ttaatgaaga tggaaatgag attttcaaca catcattatt     3600

tgaaccacct cctccaggat atgaaaatgt ttcggatatt gtaccacctt tcagtgcttt     3660

ctctcctcaa ggaatgccag agggcgatct agtgtatgtt aactatgcac gaactgaaga     3720

cttctttaaa ttggaacggg acatgaaaat caattgctct gggaaaattg taattgccag     3780

atatgggaaa gttttcagag gaaataaggt taaaaatgcc cagctggcag gggccaaagg     3840

agtcattctc tactccgacc ctgctgacta ctttgctcct ggggtgaagt cctatccaga     3900

tggttggaat cttcctggag gtggtgtcca gcgtggaaat atcctaaatc tgaatggtgc     3960

aggagaccct ctcacaccag gttacccagc aaatgaatat gcttataggc gtggaattgc     4020

agaggctgtt ggtcttccaa gtattcctgt tcatccaatt ggatactatg atgcacagaa     4080

gctcctagaa aaaatgggtg gctcagcacc accagatagc agctggagag gaagtctcaa     4140

agtgccctac aatgttggac ctggctttac tggaaacttt tctacacaaa aagtcaagat     4200

gcacatccac tctaccaatg aagtgacaag aatttacaat gtgataggta ctctcagagg     4260

agcagtggaa ccagacagat atgtcattct gggaggtcac cgggactcat gggtgtttgg     4320

tggtattgac cctcagagtg gagcagctgt tgttcatgaa attgtgagga gctttggaac     4380

actgaaaaag gaagggtgga gacctagaag aacaattttg tttgcaagct gggatgcaga     4440

agaatttggt cttcttggtt ctactgagtg ggcagaggag aattcaagac tccttcaaga     4500

gcgtggcgtg gcttatatta atgctgactc atctatagaa ggaaactaca ctctgagagt     4560

tgattgtaca ccgctgatgt acagcttggt acacaaccta acaaaagagc tgaaaagccc     4620

tgatgaaggc tttgaaggca aatctcttta tgaaagttgg actaaaaaaa gtccttcccc     4680

agagttcagt ggcatgccca ggataagcaa attgggatct ggaaatgatt ttgaggtgtt     4740

cttccaacga cttggaattg cttcaggcag agcacggtat actaaaaatt gggaaacaaa     4800

caaattcagc ggctatccac tgtatcacag tgtctatgaa acatatgagt tggtggaaaa     4860

gttttatgat ccaatgttta aatatcacct cactgtggcc caggttcgag gagggatggt     4920

gtttgagctg gccaattcca tagtgctccc ttttgattgt cgagattatg ctgtagtttt     4980

aagaaagtat gctgacaaaa tctacagtat ttctatgaaa catccacagg aaatgaagac     5040

atacagtgta tcatttgatt cacttttttc tgcagtaaag aattttacag aaattgcttc     5100

caagttcagt gagagactcc aggactttga caaaagcaac ccaatagtat taagaatgat     5160

gaatgatcaa ctcatgtttc tggaaagagc atttattgat ccattagggt taccagacag     5220

gcctttttat aggcatgtca tctatgctcc aagcagccac aacaagtatg caggggagtc     5280

attcccagga atttatgatg ctctgtttga tattgaaagc aaagtggacc cttccaaggc     5340

ctggggagaa gtgaagagac agatttatgt tgcagccttc acagtgcagg cagctgcaga     5400

gactttgagt gaagtagcct aaagatctgg gccctaacaa aacaaaaaga tggggttatt     5460

ccctaaactt catgggttac gtaattggaa gttgggggac attgccacaa gatcatattg     5520

tacaaaagat caaacactgt tttagaaaac ttcctgtaaa caggcctatt gattggaaag     5580

tatgtcaaag gattgtgggt cttttgggct ttgctgctcc atttacacaa tgtggatatc     5640

ctgccttaat gcctttgtat gcatgtatac aagctaaaca ggctttcact ttctcgccaa     5700

cttacaaggc ctttctaagt aaacagtaca tgaaccttta ccccgttgct cggcaacggc     5760

ctggtctgtg ccaagtgttt gctgacgcaa cccccactgg ctggggcttg gccataggcc     5820

atcagcgcat gcgtggaacc tttgtggctc ctctgccgat ccatactgcg gaactcctag     5880

ccgcttgttt tgctcgcagc cggtctggag caaagctcat aggaactgac aattctgtcg     5940

tcctctcgcg gaaatataca tcgtttcgat ctacgtatga tctttttccc tctgccaaaa     6000

attatgggga catcatgaag ccccttgagc atctgacttc tggctaataa aggaaattta     6060

ttttcattgc aatagtgtgt tggaattttt tgtgtctctc actcggaagg aattctgcat     6120

taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc     6180

tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca     6240

aaggcggtaa tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca     6300

aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg     6360

ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg     6420

acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt     6480

ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt     6540

tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc     6600

tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt     6660

gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt     6720

agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc     6780

tacactagaa gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa     6840

agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt     6900

tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct     6960

acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta     7020

tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa     7080

agtatatatg agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc     7140

tcagcgatct gtctatttcg ttcatccata gttgcctgac tc                        7182


<210>  47
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu 
                165                 170                 175     


His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val 
            180                 185                 190         


Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr 
        195                 200                 205             


Cys Ser Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Gly Val Leu Gln 
    210                 215                 220                 


Gly Ile Thr Ser Trp Gly Ser Glu Pro Cys Ala Leu Pro Glu Arg Pro 
225                 230                 235                 240 


Ser Leu Tyr Thr Lys Val Val His Tyr Arg Lys Trp Ile Lys Asp Thr 
                245                 250                 255     


Ile Val Ala Asn Pro 
            260     


<210>  48
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Lys Ala Val Leu Leu Ala Leu Leu Met Ala Gly Leu Ala Leu Gln 
1               5                   10                  15      


Pro Gly Thr Ala Leu Leu Cys Tyr Ser Cys Lys Ala Gln Val Ser Asn 
            20                  25                  30          


Glu Asp Cys Leu Gln Val Glu Asn Cys Thr Gln Leu Gly Glu Gln Cys 
        35                  40                  45              


Trp Thr Ala Arg Ile Arg Ala Val Gly Leu Leu Thr Val Ile Ser Lys 
    50                  55                  60                  


Gly Cys Ser Leu Asn Cys Val Asp Asp Ser Gln Asp Tyr Tyr Val Gly 
65                  70                  75                  80  


Lys Lys Asn Ile Thr Cys Cys Asp Thr Asp Leu Cys Asn Ala Ser Gly 
                85                  90                  95      


Ala His Ala Leu Gln Pro Ala Ala Ala Ile Leu Ala Leu Leu Pro Ala 
            100                 105                 110         


Leu Gly Leu Leu Leu Trp Gly Pro Gly Gln Leu 
        115                 120             


<210>  49
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  49
tcgtcgtttt gtcgttttgt cgtt                                              24


<210>  50
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50
tcgtcgtttt tcggtgcttt t                                                 21


<210>  51
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  51
tcgtcgtttt tcggtcgttt t                                                 21


