                         SEQUENCE LISTING

<110>  SERVICIO ANDALUZ DE SALUD
       UNIVERSIDAD DE CRDOBA
 
<120>  Mtodo de obtencin de datos tiles para el cribado de pacientes 
       con cncer de pulmn.

<130>  P11582PC00

<150>	ES P201431814
	2014-12-10

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  626
<212>  DNA
<213>  Homo sapiens

<400>  1
acatttgctt ctgacacaac tgtgttcact agcaacctca aacagacacc atggtgcatc       60

tgactcctga ggagaagtct gccgttactg ccctgtgggg caaggtgaac gtggatgaag      120

ttggtggtga ggccctgggc aggctgctgg tggtctaccc ttggacccag aggttctttg      180

agtcctttgg ggatctgtcc actcctgatg ctgttatggg caaccctaag gtgaaggctc      240

atggcaagaa agtgctcggt gcctttagtg atggcctggc tcacctggac aacctcaagg      300

gcacctttgc cacactgagt gagctgcact gtgacaagct gcacgtggat cctgagaact      360

tcaggctcct gggcaacgtg ctggtctgtg tgctggccca tcactttggc aaagaattca      420

ccccaccagt gcaggctgcc tatcagaaag tggtggctgg tgtggctaat gccctggccc      480

acaagtatca ctaagctcgc tttcttgctg tccaatttct attaaaggtt cctttgttcc      540

ctaagtccaa ctactaaact gggggatatt atgaagggcc ttgagcatct ggattctgcc      600

taataaaaaa catttatttt cattgc                                           626


<210>  2
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Thr Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp 
65                  70                  75                  80  


Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln 
        115                 120                 125             


Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  3
<211>  2450
<212>  DNA
<213>  Homo sapiens

<400>  3
atatttcata cctttctaga aactgggtgt gatctcactg ttggtaaagc ccagcccttc       60

ccaacctgca agctcacctt ccaggactgg gcccagccca tgctctccat atataagctg      120

ctgccccgag cctgattcct agtcctgctt ctcttccctc tctcctccag cctctcacac      180

tctcctcagc tctctcatct cctggaacca tggccagcac atccaccacc atcaggagcc      240

acagcagcag ccgccggggt ttcagtgcca actcagccag gctccctggg gtcagccgct      300

ctggcttcag cagcgtctcc gtgtcccgct ccaggggcag tggtggcctg ggtggtgcat      360

gtggaggagc tggctttggc agccgcagtc tgtatggcct ggggggctcc aagaggatct      420

ccattggagg gggcagctgt gccatcagtg gcggctatgg cagcagagcc ggaggcagct      480

atggctttgg tggcgccggg agtggatttg gtttcggtgg tggagccggc attggctttg      540

gtctgggtgg tggagccggc cttgctggtg gctttggggg ccctggcttc cctgtgtgcc      600

cccctggagg catccaagag gtcaccgtca accagagtct cctgactccc ctcaacctgc      660

aaatcgatcc caccatccag cgggtgcggg ctgaggagcg tgaacagatc aagaccctca      720

acaacaagtt tgcctccttc atcgacaagg tgcggttcct ggagcagcag aacaaggttc      780

tggaaacaaa gtggaccctg ctgcaggagc agggcaccaa gactgtgagg cagaacctgg      840

agccgttgtt cgagcagtac atcaacaacc tcaggaggca gctggacagc attgtcgggg      900

aacggggccg cctggactca gagctcagag gcatgcagga cctggtggag gacttcaaga      960

acaaatatga ggatgaaatc aacaagcgca cagcagcaga gaatgaattt gtgactctga     1020

agaaggatgt ggatgctgcc tacatgaaca aggttgaact gcaagccaag gcagacactc     1080

tcacagacga gatcaacttc ctgagagcct tgtatgatgc agagctgtcc cagatgcaga     1140

cccacatctc agacacatct gtggtgctgt ccatggacaa caaccgcaac ctggacctgg     1200

acagcatcat cgctgaggtc aaggcccaat atgaggagat tgctcagaga agccgggctg     1260

aggctgagtc ctggtaccag accaagtacg aggagctgca ggtcacagca ggcagacatg     1320

gggacgacct gcgcaacacc aagcaggaga ttgctgagat caaccgcatg atccagaggc     1380

tgagatctga gatcgaccac gtcaagaagc agtgcgccaa cctgcaggcc gccattgctg     1440

atgctgagca gcgtggggag atggccctca aggatgccaa gaacaagctg gaagggctgg     1500

aggatgccct gcagaaggcc aagcaggacc tggcccggct gctgaaggag taccaggagc     1560

tgatgaatgt caagctggcc ctggacgtgg agatcgccac ctaccgcaag ctgctggagg     1620

gtgaggagtg caggctgaat ggcgaaggcg ttggacaagt caacatctct gtggtgcagt     1680

ccaccgtctc cagtggctat ggcggtgcca gtggtgtcgg cagtggctta ggcctgggtg     1740

gaggaagcag ctactcctat ggcagtggtc ttggcgttgg aggtggcttc agttccagca     1800

gtggcagagc cattgggggt ggcctcagct ctgttggagg cggcagttcc accatcaagt     1860

acaccaccac ctcctcctcc agcaggaaga gctataagca ctaaagtgcg tctgctagct     1920

ctcggtccca cagtcctcag gcccctctct ggctgcagag ccctctcctc aggttgcctt     1980

tcctctcctg gcctccagtc tcccctgctg tcccaggtag agctgggtat ggatgcttag     2040

tgccctcact tcttctctct ctctctatac catctgagca cccattgctc accatcagat     2100

caacctctga ttttacatca tgatgtaatc accactggag cttcactgtt actaaattat     2160

taatttcttg cctccagtgt tctatctctg aggctgagca ttataagaaa atgacctctg     2220

ctccttttca ttgcagaaaa ttgccagggg cttatttcag aacaacttcc acttactttc     2280

cactggctct caaactctct aacttataag tgttgtgaac ccccacccag gcagtatcca     2340

tgaaagcaca agtgactagt cctatgatgt acaaagcctg tatctctgtg atgatttctg     2400

tgctcttcgc tgtttgcaat tgctaaataa agcagattta taatacaata                2450


<210>  4
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ser Thr Ser Thr Thr Ile Arg Ser His Ser Ser Ser Arg Arg 
1               5                   10                  15      


Gly Phe Ser Ala Asn Ser Ala Arg Leu Pro Gly Val Ser Arg Ser Gly 
            20                  25                  30          


Phe Ser Ser Val Ser Val Ser Arg Ser Arg Gly Ser Gly Gly Leu Gly 
        35                  40                  45              


Gly Ala Cys Gly Gly Ala Gly Phe Gly Ser Arg Ser Leu Tyr Gly Leu 
    50                  55                  60                  


Gly Gly Ser Lys Arg Ile Ser Ile Gly Gly Gly Ser Cys Ala Ile Ser 
65                  70                  75                  80  


Gly Gly Tyr Gly Ser Arg Ala Gly Gly Ser Tyr Gly Phe Gly Gly Ala 
                85                  90                  95      


Gly Ser Gly Phe Gly Phe Gly Gly Gly Ala Gly Ile Gly Phe Gly Leu 
            100                 105                 110         


Gly Gly Gly Ala Gly Leu Ala Gly Gly Phe Gly Gly Pro Gly Phe Pro 
        115                 120                 125             


Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr Val Asn Gln Ser Leu 
    130                 135                 140                 


Leu Thr Pro Leu Asn Leu Gln Ile Asp Pro Thr Ile Gln Arg Val Arg 
145                 150                 155                 160 


Ala Glu Glu Arg Glu Gln Ile Lys Thr Leu Asn Asn Lys Phe Ala Ser 
                165                 170                 175     


Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Val Leu Glu 
            180                 185                 190         


Thr Lys Trp Thr Leu Leu Gln Glu Gln Gly Thr Lys Thr Val Arg Gln 
        195                 200                 205             


Asn Leu Glu Pro Leu Phe Glu Gln Tyr Ile Asn Asn Leu Arg Arg Gln 
    210                 215                 220                 


Leu Asp Ser Ile Val Gly Glu Arg Gly Arg Leu Asp Ser Glu Leu Arg 
225                 230                 235                 240 


Gly Met Gln Asp Leu Val Glu Asp Phe Lys Asn Lys Tyr Glu Asp Glu 
                245                 250                 255     


Ile Asn Lys Arg Thr Ala Ala Glu Asn Glu Phe Val Thr Leu Lys Lys 
            260                 265                 270         


Asp Val Asp Ala Ala Tyr Met Asn Lys Val Glu Leu Gln Ala Lys Ala 
        275                 280                 285             


Asp Thr Leu Thr Asp Glu Ile Asn Phe Leu Arg Ala Leu Tyr Asp Ala 
    290                 295                 300                 


Glu Leu Ser Gln Met Gln Thr His Ile Ser Asp Thr Ser Val Val Leu 
305                 310                 315                 320 


Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp Ser Ile Ile Ala Glu 
                325                 330                 335     


Val Lys Ala Gln Tyr Glu Glu Ile Ala Gln Arg Ser Arg Ala Glu Ala 
            340                 345                 350         


Glu Ser Trp Tyr Gln Thr Lys Tyr Glu Glu Leu Gln Val Thr Ala Gly 
        355                 360                 365             


Arg His Gly Asp Asp Leu Arg Asn Thr Lys Gln Glu Ile Ala Glu Ile 
    370                 375                 380                 


Asn Arg Met Ile Gln Arg Leu Arg Ser Glu Ile Asp His Val Lys Lys 
385                 390                 395                 400 


Gln Cys Ala Asn Leu Gln Ala Ala Ile Ala Asp Ala Glu Gln Arg Gly 
                405                 410                 415     


Glu Met Ala Leu Lys Asp Ala Lys Asn Lys Leu Glu Gly Leu Glu Asp 
            420                 425                 430         


Ala Leu Gln Lys Ala Lys Gln Asp Leu Ala Arg Leu Leu Lys Glu Tyr 
        435                 440                 445             


Gln Glu Leu Met Asn Val Lys Leu Ala Leu Asp Val Glu Ile Ala Thr 
    450                 455                 460                 


Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Leu Asn Gly Glu Gly 
465                 470                 475                 480 


Val Gly Gln Val Asn Ile Ser Val Val Gln Ser Thr Val Ser Ser Gly 
                485                 490                 495     


Tyr Gly Gly Ala Ser Gly Val Gly Ser Gly Leu Gly Leu Gly Gly Gly 
            500                 505                 510         


Ser Ser Tyr Ser Tyr Gly Ser Gly Leu Gly Val Gly Gly Gly Phe Ser 
        515                 520                 525             


Ser Ser Ser Gly Arg Ala Ile Gly Gly Gly Leu Ser Ser Val Gly Gly 
    530                 535                 540                 


Gly Ser Ser Thr Ile Lys Tyr Thr Thr Thr Ser Ser Ser Ser Arg Lys 
545                 550                 555                 560 


Ser Tyr Lys His 
                


<210>  5
<211>  2331
<212>  DNA
<213>  Homo sapiens

<400>  5
cgcctccagc ctctcacact ctcctaagcc ctctcatctc ctggaaccat ggccagcaca       60

tccaccacca tcaggagcca cagcagcagc cgccggggtt tcagtgccaa ctcagccagg      120

ctccctgggg tcagccgctc tggcttcagc agcatctccg tgtcccgctc caggggcagt      180

ggtggcctgg gtggcgcatg tggaggagct ggctttggca gccgcagtct gtatggcctg      240

gggggctcca agaggatctc cattggaggg ggcagctgtg ccatcagtgg cggctatggc      300

agcagagccg gaggcagcta tggctttggt ggcgccggga gtggatttgg tttcggtggt      360

ggagccggca ttggctttgg tctgggtggt ggagccggcc ttgctggtgg ctttgggggc      420

cctggcttcc ctgtgtgccc ccctggaggc atccaagagg tcactgtcaa ccagagtctc      480

ctgactcccc tcaacctgca aattgacccc gccatccagc gggtgcgggc cgaggagcgt      540

gagcagatca agaccctcaa caacaagttt gcctccttca tcgacaaggt gcggttccta      600

gagcagcaga acaaggttct ggacaccaag tggaccctgc tgcaggagca gggcaccaag      660

actgtgaggc agaacctgga gccgttgttc gagcagtaca tcaacaacct caggaggcag      720

ctggacaaca tcgtggggga acggggtcgt ctggactcgg agctgagaaa catgcaggac      780

ctggtggagg acctcaagaa caaatatgag gatgaaatca acaagcgcac agcagcagag      840

aatgaatttg tgactctgaa gaaggatgtg gatgctgcct acatgaacaa ggttgaactg      900

caagccaagg cagacactct tacagatgag atcaacttcc tgagagcctt gtatgatgca      960

gagctgtccc agatgcagac ccacatctca gacacatccg tggtgctatc catggacaac     1020

aaccgcaacc tggacctgga cagcatcatc gctgaggtca aggcccaata tgaggagatt     1080

gctcagagga gcagggctga ggctgagtcc tggtaccaga caaagtacga ggagctgcag     1140

atcacagcag gcagacatgg ggacgacctg cgcaacacca agcaggagat tgctgagatc     1200

aaccgcatga tccagaggct gagatctgag atcgaccacg tcaagaagca gtgtgccaac     1260

ctacaggccg ccattgctga tgctgagcag cgtggggaga tggccctcaa ggatgctaag     1320

aacaagctgg aagggctgga ggatgccctg cagaaggcca agcaggacct ggcccggctg     1380

ctgaaggagt accaggagct gatgaacgtc aagctggccc tggatgtgga gatcgccacc     1440

taccgcaagc tgctggaggg cgaggagtgc aggctgaatg gcgaaggcgt tggacaagtc     1500

aacatctctg tagtgcagtc caccgtctcc agtggctatg gcggtgccag cggtgtcggc     1560

agtggcttag gcctgggtgg aggaagcagc tactcctatg gcagtggtct tggcgttgga     1620

ggcggcttta gttccagcag cggcagagcc actgggggtg gcctcagctc tgttggaggc     1680

ggcagttcca ccatcaagta caccaccacc tcctcctcca gcaggaagag ctacaagcac     1740

tgaagtgctg ccgccagctc tcagtcccac agctctcagg cccctctctg gcagcagagc     1800

cctctcctca ggttgcttgt cctcccctgg cctccagtct cccctgccct cccgggtaga     1860

gctgggatgc cctcactttt cttctcatca atacctgttc cactgagctc ctgttgctta     1920

ccatcaagtc aacagttatc agcactcaga catgcgaatg tcctttttag ttcccgtatt     1980

attacaggta tctgagtctg ccataattct gagaagaaaa tgacctatat ccccataaga     2040

actgaaactc agtctaggtc cagctgcaga tgaggagtcc tctctttaat tgctaaccat     2100

cctgcccatt atagctacac tcaggagttc tcatctgaca agtcagttgt cctgatcttc     2160

tcttgcagtg tccctgaatg gcaagtgatg taccttctga tgcagtctgc attcctgcac     2220

tgctttctct gctctctttg ccttcttttg ttctgttgaa taaagcatat tgagaatgtg     2280

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a              2331


<210>  6
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ser Thr Ser Thr Thr Ile Arg Ser His Ser Ser Ser Arg Arg 
1               5                   10                  15      


Gly Phe Ser Ala Asn Ser Ala Arg Leu Pro Gly Val Ser Arg Ser Gly 
            20                  25                  30          


Phe Ser Ser Ile Ser Val Ser Arg Ser Arg Gly Ser Gly Gly Leu Gly 
        35                  40                  45              


Gly Ala Cys Gly Gly Ala Gly Phe Gly Ser Arg Ser Leu Tyr Gly Leu 
    50                  55                  60                  


Gly Gly Ser Lys Arg Ile Ser Ile Gly Gly Gly Ser Cys Ala Ile Ser 
65                  70                  75                  80  


Gly Gly Tyr Gly Ser Arg Ala Gly Gly Ser Tyr Gly Phe Gly Gly Ala 
                85                  90                  95      


Gly Ser Gly Phe Gly Phe Gly Gly Gly Ala Gly Ile Gly Phe Gly Leu 
            100                 105                 110         


Gly Gly Gly Ala Gly Leu Ala Gly Gly Phe Gly Gly Pro Gly Phe Pro 
        115                 120                 125             


Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr Val Asn Gln Ser Leu 
    130                 135                 140                 


Leu Thr Pro Leu Asn Leu Gln Ile Asp Pro Ala Ile Gln Arg Val Arg 
145                 150                 155                 160 


Ala Glu Glu Arg Glu Gln Ile Lys Thr Leu Asn Asn Lys Phe Ala Ser 
                165                 170                 175     


Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Val Leu Asp 
            180                 185                 190         


Thr Lys Trp Thr Leu Leu Gln Glu Gln Gly Thr Lys Thr Val Arg Gln 
        195                 200                 205             


Asn Leu Glu Pro Leu Phe Glu Gln Tyr Ile Asn Asn Leu Arg Arg Gln 
    210                 215                 220                 


Leu Asp Asn Ile Val Gly Glu Arg Gly Arg Leu Asp Ser Glu Leu Arg 
225                 230                 235                 240 


Asn Met Gln Asp Leu Val Glu Asp Leu Lys Asn Lys Tyr Glu Asp Glu 
                245                 250                 255     


Ile Asn Lys Arg Thr Ala Ala Glu Asn Glu Phe Val Thr Leu Lys Lys 
            260                 265                 270         


Asp Val Asp Ala Ala Tyr Met Asn Lys Val Glu Leu Gln Ala Lys Ala 
        275                 280                 285             


Asp Thr Leu Thr Asp Glu Ile Asn Phe Leu Arg Ala Leu Tyr Asp Ala 
    290                 295                 300                 


Glu Leu Ser Gln Met Gln Thr His Ile Ser Asp Thr Ser Val Val Leu 
305                 310                 315                 320 


Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp Ser Ile Ile Ala Glu 
                325                 330                 335     


Val Lys Ala Gln Tyr Glu Glu Ile Ala Gln Arg Ser Arg Ala Glu Ala 
            340                 345                 350         


Glu Ser Trp Tyr Gln Thr Lys Tyr Glu Glu Leu Gln Ile Thr Ala Gly 
        355                 360                 365             


Arg His Gly Asp Asp Leu Arg Asn Thr Lys Gln Glu Ile Ala Glu Ile 
    370                 375                 380                 


Asn Arg Met Ile Gln Arg Leu Arg Ser Glu Ile Asp His Val Lys Lys 
385                 390                 395                 400 


Gln Cys Ala Asn Leu Gln Ala Ala Ile Ala Asp Ala Glu Gln Arg Gly 
                405                 410                 415     


Glu Met Ala Leu Lys Asp Ala Lys Asn Lys Leu Glu Gly Leu Glu Asp 
            420                 425                 430         


Ala Leu Gln Lys Ala Lys Gln Asp Leu Ala Arg Leu Leu Lys Glu Tyr 
        435                 440                 445             


Gln Glu Leu Met Asn Val Lys Leu Ala Leu Asp Val Glu Ile Ala Thr 
    450                 455                 460                 


Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Leu Asn Gly Glu Gly 
465                 470                 475                 480 


Val Gly Gln Val Asn Ile Ser Val Val Gln Ser Thr Val Ser Ser Gly 
                485                 490                 495     


Tyr Gly Gly Ala Ser Gly Val Gly Ser Gly Leu Gly Leu Gly Gly Gly 
            500                 505                 510         


Ser Ser Tyr Ser Tyr Gly Ser Gly Leu Gly Val Gly Gly Gly Phe Ser 
        515                 520                 525             


Ser Ser Ser Gly Arg Ala Thr Gly Gly Gly Leu Ser Ser Val Gly Gly 
    530                 535                 540                 


Gly Ser Ser Thr Ile Lys Tyr Thr Thr Thr Ser Ser Ser Ser Arg Lys 
545                 550                 555                 560 


Ser Tyr Lys His 
                


<210>  7
<211>  2345
<212>  DNA
<213>  Homo sapiens

<400>  7
cgcctccagc ctccaacgct cgccacagcc ctctcatctc ctggaaccat ggccagcaca       60

tccaccacca tcaggagcca cagcagcagc cgccggggtt tcagtgccaa ctcagccagg      120

ctccctgggg tcagccgctc tggcttcagc agcatctccg tgtcccgctc caggggcagt      180

ggtggcctgg gtggtgcatg tggaggagct ggctttggca gccgcagtct gtatggcctg      240

gggggctcca agaggatctc cattggaggg ggcagctgtg ccatcagtgg cggctatggc      300

agcagagccg gaggcagcta tggctttggt ggcgccggga gtggatttgg tttcggtggt      360

ggagccggca ttggctttgg tctgggtggt ggagccggcc ttgctggtgg ctttgggggc      420

cctggcttcc ctgtgtgccc ccctggaggc atccaagagg tcaccgtcaa ccagagtctc      480

ctgactcccc tcaacctgca aattgacccc gccatccagc gggtgcgggc cgaggagcgt      540

gagcagatca agaccctcaa caacaagttt gcctccttca tcgacaaggt gcggttccta      600

gagcagcaga acaaggttct ggacaccaag tggaccctgc tgcaggagca gggcaccaag      660

actgtgaggc agaacctgga gccgttgttc gagcagtaca tcaacaacct caggaggcag      720

ctggacagca tcgtcgggga acggggccgc ctggactcgg agctgagaaa catgcaggac      780

ctggtggagg acctcaagaa caaatatgag gatgaaatca acaagcgcac agcagcagag      840

aatgaatttg tgactctgaa gaaggatgtg gatgctgcct acatgaacaa ggttgaactg      900

caagccaagg cagacactct cacagatgag atcaacttcc tgagagcctt gtatgatgca      960

gagctgtccc agatgcagac ccacatctca gacacatccg tggtgctatc catggacaac     1020

aaccgcaacc tggacctgga cagcatcatc gctgaggtca aggcccaata cgaggagatt     1080

gctcagagga gccgggctga ggctgagtcc tggtaccaga ccaagtacga ggagctgcag     1140

gtcacagcag gcagacatgg ggacgacctg cgcaacacca agcaggagat tgctgagatc     1200

aaccgcatga tccagaggct gagatctgag atcgaccatg tcaagaagca gtgtgccagc     1260

ctgcaggctg ccattgctga tgctgagcag cgtggggaga tggcactcaa ggatgctaag     1320

aacaagctgg aagggctgga ggatgccctg cagaaggcca agcaggacct ggcccggctg     1380

ctgaaggagt accaggagct gatgaatgtc aagctggccc tggatgtgga gatcgccacc     1440

taccgcaagc tgctggaggg cgaggagtgc aggctgaatg gcgaaggcgt tggacaagtc     1500

aacgtctctg tagtacagtc caccatctcc agtggctatg gcggtgccag cggtgtcggc     1560

agtggcttag gcctgggtgg aggaagcagc tactcctatg gcagtggtct tggcattgga     1620

ggtggcttca gttccagcag tggcagagcc attgggggtg gcctcagctc tgttggaggc     1680

ggcagttcca ccatcaagta caccaccacc tcctcctcca gcaggaagag ctacaagcac     1740

taaagtgctg cctccagctc tcggtcccac agtcctcagg cccttctctg gctgcagagc     1800

cgtctcctca ggttgcctat cctctcctgg cctctagtct tccctgctct ccgaggtaga     1860

gctgggtatg gatgcttagt gccctcactt ctctctgtct atacctgccc catctgagca     1920

cccattgctc accatcagat caacctttga ttttacatca taatgtattc accaatggag     1980

cttcactttg ttactaaatt attaatttct tgcctccaaa attgttctct ctgaggctga     2040

gcattataag aaaatgatct ctgttccttt tcattactga aaatcgcctg gggcttattt     2100

cagaacaact tccacttatt ttccattggc ccccaaactc cctaagttaa aagtattgtg     2160

aacccccgcc ccgcagtatg catggaagca caagtgacta gtcgtatgat gtacacagtc     2220

tttctccctg tgatgatttc tctgctcttt gctctttgta atttctaaat aaagcaggtt     2280

ttagaataaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2340

aaaaa                                                                 2345


<210>  8
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Ser Thr Ser Thr Thr Ile Arg Ser His Ser Ser Ser Arg Arg 
1               5                   10                  15      


Gly Phe Ser Ala Asn Ser Ala Arg Leu Pro Gly Val Ser Arg Ser Gly 
            20                  25                  30          


Phe Ser Ser Ile Ser Val Ser Arg Ser Arg Gly Ser Gly Gly Leu Gly 
        35                  40                  45              


Gly Ala Cys Gly Gly Ala Gly Phe Gly Ser Arg Ser Leu Tyr Gly Leu 
    50                  55                  60                  


Gly Gly Ser Lys Arg Ile Ser Ile Gly Gly Gly Ser Cys Ala Ile Ser 
65                  70                  75                  80  


Gly Gly Tyr Gly Ser Arg Ala Gly Gly Ser Tyr Gly Phe Gly Gly Ala 
                85                  90                  95      


Gly Ser Gly Phe Gly Phe Gly Gly Gly Ala Gly Ile Gly Phe Gly Leu 
            100                 105                 110         


Gly Gly Gly Ala Gly Leu Ala Gly Gly Phe Gly Gly Pro Gly Phe Pro 
        115                 120                 125             


Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr Val Asn Gln Ser Leu 
    130                 135                 140                 


Leu Thr Pro Leu Asn Leu Gln Ile Asp Pro Ala Ile Gln Arg Val Arg 
145                 150                 155                 160 


Ala Glu Glu Arg Glu Gln Ile Lys Thr Leu Asn Asn Lys Phe Ala Ser 
                165                 170                 175     


Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Val Leu Asp 
            180                 185                 190         


Thr Lys Trp Thr Leu Leu Gln Glu Gln Gly Thr Lys Thr Val Arg Gln 
        195                 200                 205             


Asn Leu Glu Pro Leu Phe Glu Gln Tyr Ile Asn Asn Leu Arg Arg Gln 
    210                 215                 220                 


Leu Asp Ser Ile Val Gly Glu Arg Gly Arg Leu Asp Ser Glu Leu Arg 
225                 230                 235                 240 


Asn Met Gln Asp Leu Val Glu Asp Leu Lys Asn Lys Tyr Glu Asp Glu 
                245                 250                 255     


Ile Asn Lys Arg Thr Ala Ala Glu Asn Glu Phe Val Thr Leu Lys Lys 
            260                 265                 270         


Asp Val Asp Ala Ala Tyr Met Asn Lys Val Glu Leu Gln Ala Lys Ala 
        275                 280                 285             


Asp Thr Leu Thr Asp Glu Ile Asn Phe Leu Arg Ala Leu Tyr Asp Ala 
    290                 295                 300                 


Glu Leu Ser Gln Met Gln Thr His Ile Ser Asp Thr Ser Val Val Leu 
305                 310                 315                 320 


Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp Ser Ile Ile Ala Glu 
                325                 330                 335     


Val Lys Ala Gln Tyr Glu Glu Ile Ala Gln Arg Ser Arg Ala Glu Ala 
            340                 345                 350         


Glu Ser Trp Tyr Gln Thr Lys Tyr Glu Glu Leu Gln Val Thr Ala Gly 
        355                 360                 365             


Arg His Gly Asp Asp Leu Arg Asn Thr Lys Gln Glu Ile Ala Glu Ile 
    370                 375                 380                 


Asn Arg Met Ile Gln Arg Leu Arg Ser Glu Ile Asp His Val Lys Lys 
385                 390                 395                 400 


Gln Cys Ala Ser Leu Gln Ala Ala Ile Ala Asp Ala Glu Gln Arg Gly 
                405                 410                 415     


Glu Met Ala Leu Lys Asp Ala Lys Asn Lys Leu Glu Gly Leu Glu Asp 
            420                 425                 430         


Ala Leu Gln Lys Ala Lys Gln Asp Leu Ala Arg Leu Leu Lys Glu Tyr 
        435                 440                 445             


Gln Glu Leu Met Asn Val Lys Leu Ala Leu Asp Val Glu Ile Ala Thr 
    450                 455                 460                 


Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Leu Asn Gly Glu Gly 
465                 470                 475                 480 


Val Gly Gln Val Asn Val Ser Val Val Gln Ser Thr Ile Ser Ser Gly 
                485                 490                 495     


Tyr Gly Gly Ala Ser Gly Val Gly Ser Gly Leu Gly Leu Gly Gly Gly 
            500                 505                 510         


Ser Ser Tyr Ser Tyr Gly Ser Gly Leu Gly Ile Gly Gly Gly Phe Ser 
        515                 520                 525             


Ser Ser Ser Gly Arg Ala Ile Gly Gly Gly Leu Ser Ser Val Gly Gly 
    530                 535                 540                 


Gly Ser Ser Thr Ile Lys Tyr Thr Thr Thr Ser Ser Ser Ser Arg Lys 
545                 550                 555                 560 


Ser Tyr Lys His 
                


<210>  9
<211>  2162
<212>  DNA
<213>  Homo sapiens

<400>  9
cactccctgg gctaaacagc atcaccatgt ctgttcgata cagctcaagc aagcactact       60

cttcctcccg cagtggagga ggaggaggag gaggaggatg tggaggagga ggaggagtgt      120

catccctaag aatttctagc agcaaaggct cccttggtgg aggatttagc tcaggggggt      180

tcagtggtgg ctcttttagc cgtgggagct ctggtggggg ctgctttggg ggctcatcag      240

gtggctatgg aggattagga ggttttggtg gaggtagctt tcgtggaagc tatggaagta      300

gcagctttgg tgggagttat ggaggcagct ttggaggggg cagtttcgga ggtggcagct      360

ttggtggggg cagctttggt ggaggcggct ttggtggagg cggctttgga ggaggctttg      420

gtggtggatt tggaggagat ggtggccttc tctctggaaa tgaaaaagta accatgcaga      480

atctgaatga ccgcctggct tcctacttgg acaaagttcg ggctctggaa gaatcaaact      540

atgagctgga aggcaaaatc aaggagtggt atgaaaagca tggcaactca catcaggggg      600

agcctcgtga ctacagcaaa tactacaaaa ccatcgatga ccttaaaaat cagattctca      660

acctaacaac tgataatgcc aacatcctgc ttcagatcga caatgccagg ctggcagctg      720

atgacttcag gctgaagtat gagaatgagg tagctctgcg ccagagcgtg gaggctgaca      780

tcaacggcct gcgtagggtg ctggatgagc tgaccctgac caaggctgac ctggagatgc      840

aaattgagag cctgactgaa gagctggcct atctgaagaa gaaccacgag gaggaaatga      900

aagaccttcg aaatgtgtcc actggtgatg tgaatgtgga aatgaatgct gccccgggtg      960

ttgatctgac tcaacttctg aataacatga gaagccaata tgaacaactt gctgaacaaa     1020

accgcaaaga tgctgaagcc tggttcaatg aaaagagcaa ggaactgact acagaaattg     1080

ataataacat tgaacagata tccagctata aatctgagat tactgaattg agacgtaatg     1140

tacaagctct ggagatagaa ctacagtccc aactggcctt gaaacaatcc ctggaagcct     1200

ccttggcaga aacagaaggt cgctactgtg tgcagctctc acagattcag gcccagatat     1260

ccgctctgga agaacagttg caacagattc gagctgaaac cgagtgccag aatactgaat     1320

accaacaact cctggatatt aagatccgac tggagaatga aattcaaacc taccgcagcc     1380

tgctagaagg agagggaagt tccggaggcg gcggacgcgg cggcggaagt ttcggcggcg     1440

gctacggcgg cggaagctcc ggcggcggaa gctccggcgg cggccacggc ggcggccacg     1500

gcggcagttc cggcggcggc tacggaggcg gaagctccgg cggcggaagc tccggcggcg     1560

gctacggggg cggaagctcc agcggcggcc acggcggcag ttccagcggc ggctacggtg     1620

gtggcagttc cggcggcggc ggcggcggct acgggggcgg cagctccggc ggcggcagca     1680

gctccggcgg cggatacggc ggcggcagct ccagcggagg ccacaagtcc tcctcttccg     1740

ggtccgtggg cgagtcttca tctaagggac caagatacta acaaaaccag agtaatcaag     1800

acaattattg aagaggtggc gcccgacggt agagttcttt catctatggt tgaatcagaa     1860

accaagaaac actactatta aactgcatca agaggaaaga gtctcccttc acacagacca     1920

ttatttacag atgcatggaa aacaaagtct ccaagaaaac acttctgtct tgatggtcta     1980

tggaaataga ccttgaaaat aaggtgtcta caaggtgttt tgtggtttct gtatttcttc     2040

ttttcacttt accagaaagt gttctttaat ggaaagaaaa acaactttct gttctcattt     2100

actaatgaat ttcaataaac tttcttactg atgcaaacta aaaaaaaaaa aaaaaaaaaa     2160

aa                                                                    2162


<210>  10
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Val Arg Tyr Ser Ser Ser Lys His Tyr Ser Ser Ser Arg Ser 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Cys Gly Gly Gly Gly Gly Val Ser 
            20                  25                  30          


Ser Leu Arg Ile Ser Ser Ser Lys Gly Ser Leu Gly Gly Gly Phe Ser 
        35                  40                  45              


Ser Gly Gly Phe Ser Gly Gly Ser Phe Ser Arg Gly Ser Ser Gly Gly 
    50                  55                  60                  


Gly Cys Phe Gly Gly Ser Ser Gly Gly Tyr Gly Gly Leu Gly Gly Phe 
65                  70                  75                  80  


Gly Gly Gly Ser Phe Arg Gly Ser Tyr Gly Ser Ser Ser Phe Gly Gly 
                85                  90                  95      


Ser Tyr Gly Gly Ser Phe Gly Gly Gly Ser Phe Gly Gly Gly Ser Phe 
            100                 105                 110         


Gly Gly Gly Ser Phe Gly Gly Gly Gly Phe Gly Gly Gly Gly Phe Gly 
        115                 120                 125             


Gly Gly Phe Gly Gly Gly Phe Gly Gly Asp Gly Gly Leu Leu Ser Gly 
    130                 135                 140                 


Asn Glu Lys Val Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser Tyr 
145                 150                 155                 160 


Leu Asp Lys Val Arg Ala Leu Glu Glu Ser Asn Tyr Glu Leu Glu Gly 
                165                 170                 175     


Lys Ile Lys Glu Trp Tyr Glu Lys His Gly Asn Ser His Gln Gly Glu 
            180                 185                 190         


Pro Arg Asp Tyr Ser Lys Tyr Tyr Lys Thr Ile Asp Asp Leu Lys Asn 
        195                 200                 205             


Gln Ile Leu Asn Leu Thr Thr Asp Asn Ala Asn Ile Leu Leu Gln Ile 
    210                 215                 220                 


Asp Asn Ala Arg Leu Ala Ala Asp Asp Phe Arg Leu Lys Tyr Glu Asn 
225                 230                 235                 240 


Glu Val Ala Leu Arg Gln Ser Val Glu Ala Asp Ile Asn Gly Leu Arg 
                245                 250                 255     


Arg Val Leu Asp Glu Leu Thr Leu Thr Lys Ala Asp Leu Glu Met Gln 
            260                 265                 270         


Ile Glu Ser Leu Thr Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu 
        275                 280                 285             


Glu Glu Met Lys Asp Leu Arg Asn Val Ser Thr Gly Asp Val Asn Val 
    290                 295                 300                 


Glu Met Asn Ala Ala Pro Gly Val Asp Leu Thr Gln Leu Leu Asn Asn 
305                 310                 315                 320 


Met Arg Ser Gln Tyr Glu Gln Leu Ala Glu Gln Asn Arg Lys Asp Ala 
                325                 330                 335     


Glu Ala Trp Phe Asn Glu Lys Ser Lys Glu Leu Thr Thr Glu Ile Asp 
            340                 345                 350         


Asn Asn Ile Glu Gln Ile Ser Ser Tyr Lys Ser Glu Ile Thr Glu Leu 
        355                 360                 365             


Arg Arg Asn Val Gln Ala Leu Glu Ile Glu Leu Gln Ser Gln Leu Ala 
    370                 375                 380                 


Leu Lys Gln Ser Leu Glu Ala Ser Leu Ala Glu Thr Glu Gly Arg Tyr 
385                 390                 395                 400 


Cys Val Gln Leu Ser Gln Ile Gln Ala Gln Ile Ser Ala Leu Glu Glu 
                405                 410                 415     


Gln Leu Gln Gln Ile Arg Ala Glu Thr Glu Cys Gln Asn Thr Glu Tyr 
            420                 425                 430         


Gln Gln Leu Leu Asp Ile Lys Ile Arg Leu Glu Asn Glu Ile Gln Thr 
        435                 440                 445             


Tyr Arg Ser Leu Leu Glu Gly Glu Gly Ser Ser Gly Gly Gly Gly Arg 
    450                 455                 460                 


Gly Gly Gly Ser Phe Gly Gly Gly Tyr Gly Gly Gly Ser Ser Gly Gly 
465                 470                 475                 480 


Gly Ser Ser Gly Gly Gly His Gly Gly Gly His Gly Gly Ser Ser Gly 
                485                 490                 495     


Gly Gly Tyr Gly Gly Gly Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly 
            500                 505                 510         


Tyr Gly Gly Gly Ser Ser Ser Gly Gly His Gly Gly Ser Ser Ser Gly 
        515                 520                 525             


Gly Tyr Gly Gly Gly Ser Ser Gly Gly Gly Gly Gly Gly Tyr Gly Gly 
    530                 535                 540                 


Gly Ser Ser Gly Gly Gly Ser Ser Ser Gly Gly Gly Tyr Gly Gly Gly 
545                 550                 555                 560 


Ser Ser Ser Gly Gly His Lys Ser Ser Ser Ser Gly Ser Val Gly Glu 
                565                 570                 575     


Ser Ser Ser Lys Gly Pro Arg Tyr 
            580                 


<210>  11
<211>  2150
<212>  DNA
<213>  Homo sapiens

<400>  11
gctaaacagc atcaccatgt ctgttcgata cagctcaagc aagcactact cttcctcccg       60

cagtggagga ggaggaggag gaggaggatg tggaggagga ggaggagtgt catccctaag      120

aatttctagc agcaaaggct cccttggtgg aggatttagc tcaggggggt tcagtggtgg      180

ctcttttagc cgtgggagct ctggtggggg ctgctttggg ggctcatcag gtggctatgg      240

aggattagga ggttttggtg gaggtagctt tcgtggaagc tatggaagta gcagctttgg      300

tgggagttat ggaggcatct ttggaggggg cagtttcgga ggtggcagct ttggtggggg      360

cagctttggt ggaggcggct ttggtggagg cggctttgga ggaggctttg gtggtggatt      420

tggaggagat ggtggccttc tctctggaaa tgaaaaagta accatgcaga atctgaatga      480

ccgcctggct tcctacttgg acaaagttcg ggctctggaa gaatcaaact atgagctgga      540

aggcaaaatc aaggagtggt atgaaaagca tggcaactca catcaggggg agcctcgtga      600

ctacagcaaa tactacaaaa ccatcgatga ccttaaaaat cagattctca acctaacaac      660

tgataatgcc aacatcctgc ttcagatcga caatgccagg ctggcagctg atgacttcag      720

gctgaagtat gagaatgagg tagctctgcg ccagagcgtg gaggctgaca tcaacggcct      780

gcgtagggtg ctggatgagc tgaccctgac caaggctgac ctggagatgc aaattgagag      840

cctgactgaa gagctggcct atctgaagaa gaaccacgag gaggaaatga aagaccttcg      900

aaatgtgtcc actggtgatg tgaatgtgga aatgaatgct gccccgggtg ttgatctgac      960

tcaacttctg aataacatga gaagccaata tgaacaactt gctgaacaaa accgcaaaga     1020

tgctgaagcc tggttcaatg aaaagagcaa ggaactgact acagaaattg ataataacat     1080

tgaacagata tccagctata aatctgagat tactgaattg agacgtaatg tacaagctct     1140

ggagatagaa ctacagtccc aactggcctt gaaacaatcc ctggaagcct ccttggcaga     1200

aacagaaggt cgctactgtg tgcagctctc acagattcag gcccagatat ccgctctgga     1260

agaacagttg caacagattc gagctgaaac cgagtgccag aatactgaat accaacaact     1320

cctggatatt aagatccgac tggagaatga aattcaaacc taccgcagcc tgctagaagg     1380

agagggaagt tccggaggcg gcggacgcgg cggcggaagt ttcggcggcg gctacggcgg     1440

cggaagctcc ggcggcggaa gctccggcgg cggccacggc ggcggccacg gcggcagttc     1500

cggcggcggc tacggaggcg gaagctccgg cggcggaagc tccggcggcg gctacggggg     1560

cggaagctcc agcggcggcc acggcggcag ttccagcggc ggctacggtg gtggcagttc     1620

cggcggcggc ggcggcggct acgggggcgg cagctccggc ggcggcagca gctccggcgg     1680

cggatacggc ggcggcagct ccagcggagg ccacaagtcc tcctcttccg ggtccgtggg     1740

cgagtcttca tctaagggac caaggtcagc agaaactagc tgggatacta acaaaaccag     1800

agtaatcaag acaattattg aagaggtggc gcccgacggt agagttcttt catctatggt     1860

tgaatcagaa accaagaaac actactatta aactgcatca agaggaaaga gtctcccttc     1920

acacagacca ttatttacag atgcatggaa aacaaagtct ccaagaaaac acttctgtct     1980

tgatggtcta tggaaataga ccttgaaaat aaggtgtcta caaggtgttt tgtggtttct     2040

gtatttcttc ttttcacttt accagaaagt gttctttaat ggaaagaaaa acaactttct     2100

gttctcattt actaatgaat ttcaataaac tttcttactg atgcaaacta                2150


<210>  12
<211>  624
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Val Arg Tyr Ser Ser Ser Lys His Tyr Ser Ser Ser Arg Ser 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Cys Gly Gly Gly Gly Gly Val Ser 
            20                  25                  30          


Ser Leu Arg Ile Ser Ser Ser Lys Gly Ser Leu Gly Gly Gly Phe Ser 
        35                  40                  45              


Ser Gly Gly Phe Ser Gly Gly Ser Phe Ser Arg Gly Ser Ser Gly Gly 
    50                  55                  60                  


Gly Cys Phe Gly Gly Ser Ser Gly Gly Tyr Gly Gly Leu Gly Gly Phe 
65                  70                  75                  80  


Gly Gly Gly Ser Phe Arg Gly Ser Tyr Gly Ser Ser Ser Phe Gly Gly 
                85                  90                  95      


Ser Tyr Gly Gly Ile Phe Gly Gly Gly Ser Phe Gly Gly Gly Ser Phe 
            100                 105                 110         


Gly Gly Gly Ser Phe Gly Gly Gly Gly Phe Gly Gly Gly Gly Phe Gly 
        115                 120                 125             


Gly Gly Phe Gly Gly Gly Phe Gly Gly Asp Gly Gly Leu Leu Ser Gly 
    130                 135                 140                 


Asn Glu Lys Val Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser Tyr 
145                 150                 155                 160 


Leu Asp Lys Val Arg Ala Leu Glu Glu Ser Asn Tyr Glu Leu Glu Gly 
                165                 170                 175     


Lys Ile Lys Glu Trp Tyr Glu Lys His Gly Asn Ser His Gln Gly Glu 
            180                 185                 190         


Pro Arg Asp Tyr Ser Lys Tyr Tyr Lys Thr Ile Asp Asp Leu Lys Asn 
        195                 200                 205             


Gln Ile Leu Asn Leu Thr Thr Asp Asn Ala Asn Ile Leu Leu Gln Ile 
    210                 215                 220                 


Asp Asn Ala Arg Leu Ala Ala Asp Asp Phe Arg Leu Lys Tyr Glu Asn 
225                 230                 235                 240 


Glu Val Ala Leu Arg Gln Ser Val Glu Ala Asp Ile Asn Gly Leu Arg 
                245                 250                 255     


Arg Val Leu Asp Glu Leu Thr Leu Thr Lys Ala Asp Leu Glu Met Gln 
            260                 265                 270         


Ile Glu Ser Leu Thr Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu 
        275                 280                 285             


Glu Glu Met Lys Asp Leu Arg Asn Val Ser Thr Gly Asp Val Asn Val 
    290                 295                 300                 


Glu Met Asn Ala Ala Pro Gly Val Asp Leu Thr Gln Leu Leu Asn Asn 
305                 310                 315                 320 


Met Arg Ser Gln Tyr Glu Gln Leu Ala Glu Gln Asn Arg Lys Asp Ala 
                325                 330                 335     


Glu Ala Trp Phe Asn Glu Lys Ser Lys Glu Leu Thr Thr Glu Ile Asp 
            340                 345                 350         


Asn Asn Ile Glu Gln Ile Ser Ser Tyr Lys Ser Glu Ile Thr Glu Leu 
        355                 360                 365             


Arg Arg Asn Val Gln Ala Leu Glu Ile Glu Leu Gln Ser Gln Leu Ala 
    370                 375                 380                 


Leu Lys Gln Ser Leu Glu Ala Ser Leu Ala Glu Thr Glu Gly Arg Tyr 
385                 390                 395                 400 


Cys Val Gln Leu Ser Gln Ile Gln Ala Gln Ile Ser Ala Leu Glu Glu 
                405                 410                 415     


Gln Leu Gln Gln Ile Arg Ala Glu Thr Glu Cys Gln Asn Thr Glu Tyr 
            420                 425                 430         


Gln Gln Leu Leu Asp Ile Lys Ile Arg Leu Glu Asn Glu Ile Gln Thr 
        435                 440                 445             


Tyr Arg Ser Leu Leu Glu Gly Glu Gly Ser Ser Gly Gly Gly Gly Arg 
    450                 455                 460                 


Gly Gly Gly Ser Phe Gly Gly Gly Tyr Gly Gly Gly Ser Ser Gly Gly 
465                 470                 475                 480 


Gly Ser Ser Gly Gly Gly His Gly Gly Gly His Gly Gly Ser Ser Gly 
                485                 490                 495     


Gly Gly Tyr Gly Gly Gly Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly 
            500                 505                 510         


Tyr Gly Gly Gly Ser Ser Ser Gly Gly His Gly Gly Ser Ser Ser Gly 
        515                 520                 525             


Gly Tyr Gly Gly Gly Ser Ser Gly Gly Gly Gly Gly Gly Tyr Gly Gly 
    530                 535                 540                 


Gly Ser Ser Gly Gly Gly Ser Ser Ser Gly Gly Gly Tyr Gly Gly Gly 
545                 550                 555                 560 


Ser Ser Ser Gly Gly His Lys Ser Ser Ser Ser Gly Ser Val Gly Glu 
                565                 570                 575     


Ser Ser Ser Lys Gly Pro Arg Ser Ala Glu Thr Ser Trp Asp Thr Asn 
            580                 585                 590         


Lys Thr Arg Val Ile Lys Thr Ile Ile Glu Glu Val Ala Pro Asp Gly 
        595                 600                 605             


Arg Val Leu Ser Ser Met Val Glu Ser Glu Thr Lys Lys His Tyr Tyr 
    610                 615                 620                 


<210>  13
<211>  437
<212>  DNA
<213>  Homo sapiens

<400>  13
atgtctggtc gtggcaaaca aggaggcaag gcccgcgcca aggccaagtc gcgctcgtcc       60

cgcgctggcc tccagttccc ggtagggcga gtgcaccgct tgctgcgcaa aggcaactac      120

gcggagcggg tgggggccgg cgcgcccgtc tacatggcgg cggtcctcga gtacctgacc      180

gccgagatcc tggagctggc gggcaacgcg gctcgggaca acaagaagac gcgcatcatc      240

cctcgtcacc tccagctggc catccgcaac gacgaggaac tgaacaagct gctgggcaaa      300

gtcaccatcg cccagggcgg cgttttgcct aacatccagg ccgttctgtt accaaagaaa      360

accgaaagcc acaaagccaa aagcaaataa atgcagacaa acaaaccaag accaaaggct      420

ctttttagag ccaccca                                                     437


<210>  14
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ser Gly Arg Gly Lys Gln Gly Gly Lys Ala Arg Ala Lys Ala Lys 
1               5                   10                  15      


Ser Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val His 
            20                  25                  30          


Arg Leu Leu Arg Lys Gly Asn Tyr Ala Glu Arg Val Gly Ala Gly Ala 
        35                  40                  45              


Pro Val Tyr Met Ala Ala Val Leu Glu Tyr Leu Thr Ala Glu Ile Leu 
    50                  55                  60                  


Glu Leu Ala Gly Asn Ala Ala Arg Asp Asn Lys Lys Thr Arg Ile Ile 
65                  70                  75                  80  


Pro Arg His Leu Gln Leu Ala Ile Arg Asn Asp Glu Glu Leu Asn Lys 
                85                  90                  95      


Leu Leu Gly Lys Val Thr Ile Ala Gln Gly Gly Val Leu Pro Asn Ile 
            100                 105                 110         


Gln Ala Val Leu Leu Pro Lys Lys Thr Glu Ser His Lys Ala Lys Ser 
        115                 120                 125             


Lys 
    


