                         SEQUENCE LISTING

<110>  ALERE TECHNOLOGIES GMBH
 
<120>  Anti-carbapenem antibodies and uses thereof

<130>  A 15093-WO

<150<  US 62/090,561

<151>  11.12.2014

<150>  GB 1503387.1

<151>  27.02.2015

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of anti-NDM antibody

<400>  1

Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Arg Gly Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Lys Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Gly Ser Gly Asn Thr His Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Thr Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Asp Leu Gly Ser Trp Phe Ala Asn Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  2
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of anti-NDM antibody

<400>  2

Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Arg Gly Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Gly Ser Gly Asn Thr His Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Thr Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Asp Leu Gly Ser Trp Phe Ala Asn Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  3
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of anti-NDM antibody

<400>  3

Gln Val Gln Leu Gln Gln Ser Glu Ala Asp Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asn Ser 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Asn Pro Gly Asp Gly Asn Thr Lys Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Val Ile Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Glu Arg Glu Thr Pro Leu Trp Ser Phe Val Tyr Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  4
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of anti-NDM antibody

<400>  4

Glu Ile Gln Leu Gln Gln Ser Gly Ala Glu Phe Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Asn Asn Gly Arg Ser Asp Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Asn Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Ser Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  5
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of anti-NDM antibody

<400>  5

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Asn Val Ser Leu Ser Cys Arg Ala Gly Gln Ser Ile Tyr Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile Ile Lys Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  6
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of anti-NDM antibody

<400>  6

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Tyr Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  7
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of anti-NDM antibody

<400>  7

Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  8
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of anti-NDM antibody

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Thr Thr Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  9
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of anti-KPC antibody

<400>  9

Gln Val Gln Leu Gln Gln Ser Arg Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Thr Tyr 
            20                  25                  30          


His Met Tyr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Ile Pro Ser Asn Gly Asp Ser Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Gln Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Lys Lys Leu Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  10
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of anti-KPC antibody

<400>  10

Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Thr Leu 
            20                  25                  30          


Asn Ile Asn Trp Val Lys Gln Lys Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Gly Ser Asp Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Val Arg Ser Pro Asn Trp Val Tyr Trp Gly Gln Gly Ser Ser Leu Thr 
            100                 105                 110         


Gly Ser Ser 
        115 


<210>  11
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of anti-KPC antibody

<400>  11

Glu Ile Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Val Ser Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Arg Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Ala Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Gly Leu Ile Thr Thr Met Ala Gly Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  12
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of anti-KPC antibody

<400>  12

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Phe Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Gly Gly Tyr Phe Asp Tyr Phe Pro Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  13
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of anti-KPC antibody

<400>  13

Gln Val Val Leu Thr Gln Ser Pro Ala Ile Ile Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Met Trp Ile Tyr 
        35                  40                  45              


Gly Ile Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105         


<210>  14
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of anti-KPC antibody

<400>  14

Asp Val Glu Met Thr Gln Ser His Ser Phe Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Thr Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Leu Glu Ser Leu Ile Ala Ser Gln Ala 
    50                  55                  60                  


Val Asp Leu Gly Gln Ile Ser Leu Ser Pro Leu Ala Met Cys Ser Leu 
65                  70                  75                  80  


Lys Thr Trp His Ile Ile Ser Val Asn Asn Ile Ala Pro Ile Leu Ser 
                85                  90                  95      


Arg Ser Glu Gly Gly Pro Ser Trp Lys Asn Gly 
            100                 105         


<210>  15
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of anti-KPC antibody

<400>  15

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Gln Gly Lys Ser Pro His Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Arg Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Asp Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  16
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of anti-KPC antibody

<400>  16

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln His Asn Glu Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  17
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of anti-VIM antibody

<400>  17

Gln Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Arg Ser Tyr 
            20                  25                  30          


Gly Ile Thr Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Glu Ser Asn Ile Ser Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Thr Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Asp Gly Ser Tyr Ile Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  18
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of anti-VIM antibody

<400>  18

Gln Val His Val Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Arg Thr Arg Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Thr Thr Ala Ser 
65                  70                  75                  80  


Met Gln Leu Ser Asn Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr His Ser Tyr Tyr Asp Leu Asp Gly Gly Leu Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 


<210>  19
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of anti-VIM antibody

<400>  19

Gln Val Gln Leu Gln Gln Pro Gly Ser Val Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Asn Ser Gly Lys Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Val Ala Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Tyr Ser Leu Tyr Asp Phe Thr Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  20
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of anti-VIM antibody

<400>  20

Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Val Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Tyr Pro Ala Ser Gly Lys Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Ile Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Val Val Tyr Phe Cys 
                85                  90                  95      


Val Arg Ser Gly Tyr Asp Gly Ser Tyr Gly Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  21
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of anti-VIM antibody

<400>  21

Gln Ile Val Leu Thr Gln Ser Pro Thr Thr Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Asn Ile Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Ser Asn 
            20                  25                  30          


Phe Leu His Gly Tyr Gln Gln Lys Pro Gly Phe Ser Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Thr Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Gly Thr Met Glu 
65                  70                  75                  80  


Ala Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Gly Asp Ser Leu Pro 
                85                  90                  95      


Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 


<210>  22
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of anti-VIM antibody

<400>  22

Asp Val Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Thr Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln His 
                85                  90                  95      


Phe Tyr Asn Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  23
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of anti-VIM antibody

<400>  23

Asp Ile Lys Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Glu Asn Val Gly Thr Phe 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Leu Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Lys Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Ala Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Ser Phe Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  24
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of anti-VIM antibody

<400>  24

Gln Ile Val Leu Thr Gln Ser Pro Thr Thr Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Ile Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Phe Ser Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Thr Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Gly Thr Met Glu 
65                  70                  75                  80  


Ala Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Gly Ser Thr Ile Pro 
                85                  90                  95      


Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 


<210>  25
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of anti-OXA-48 antibody

<400>  25

Asp Val Gln Leu Gln Gln Ser Gly Pro Glu Met Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Phe Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Val Asn Gly Asn Asn Gly Asp Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Leu Ala Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  26
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of anti-OXA-48 antibody

<400>  26

Gln Val Gln Leu Lys Gln Ser Gly Asp Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Ala Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Arg Gly Tyr 
            20                  25                  30          


Arg Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Ser Asp Thr Asn Tyr Asn Gly Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Ile Leu Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Trp Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Arg Val Ser Ser 
        115     


<210>  27
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of anti-OXA-48 antibody

<400>  27

Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Gly Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr Lys Phe Lys Ser Tyr 
            20                  25                  30          


Gly Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Gly Ser Gly Tyr Ile Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Gln Gly Glu Ala Thr Leu Thr Ser Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Gly Arg Leu Gly Asp Gly Tyr Phe Phe Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  28
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of anti-OXA-48 antibody

<400>  28

Gln Val Lys Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Asp Tyr Thr Phe Ser Gly Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Asp Pro Gly Asn Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Leu Thr Ala Asp Lys Leu Ser Tyr Thr Ala Tyr 
65                  70                  75                  80  


Met His Val Ser Ser Leu Ile Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Met Tyr Ser Asn Leu Ile Asp Tyr Trp Gly Arg Gly Thr 
            100                 105                 110         


Thr Leu Thr Leu Ser Ser 
        115             


<210>  29
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of anti-OXA-48 antibody

<400>  29

Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Ser Ile Ser Cys Arg Ala Ile Lys Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Thr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys His Gln Ser Asn 
                85                  90                  95      


Glu Ala Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  30
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of anti-OXA-48 antibody

<400>  30

Asp Val Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Lys Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys Arg 
        


<210>  31
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of anti-OXA-48 antibody

<400>  31

Gln Ile Val Leu Thr Gln Ser Pro Thr Thr Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Ile Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Phe Ser Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Gly Ser Gly Val Pro Val Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Gly Thr Met Glu 
65                  70                  75                  80  


Ala Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Gly Ser Ser Ile Pro 
                85                  90                  95      


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 


<210>  32
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of anti-OXA-48 antibody

<400>  32

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Pro Trp Tyr Gln Gln Lys Val Gly Glu Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


His Trp Ala Ser Asp Arg Ile Thr Gly Ile Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Tyr Phe Thr Leu Thr Ile Thr Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Thr Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Trp 
            100                 105             


<210>  33
<211>  270
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  33

Met Glu Leu Pro Asn Ile Met His Pro Val Ala Lys Leu Ser Thr Ala 
1               5                   10                  15      


Leu Ala Ala Ala Leu Met Leu Ser Gly Cys Met Pro Gly Glu Ile Arg 
            20                  25                  30          


Pro Thr Ile Gly Gln Gln Met Glu Thr Gly Asp Gln Arg Phe Gly Asp 
        35                  40                  45              


Leu Val Phe Arg Gln Leu Ala Pro Asn Val Trp Gln His Thr Ser Tyr 
    50                  55                  60                  


Leu Asp Met Pro Gly Phe Gly Ala Val Ala Ser Asn Gly Leu Ile Val 
65                  70                  75                  80  


Arg Asp Gly Gly Arg Val Leu Val Val Asp Thr Ala Trp Thr Asp Asp 
                85                  90                  95      


Gln Thr Ala Gln Ile Leu Asn Trp Ile Lys Gln Glu Ile Asn Leu Pro 
            100                 105                 110         


Val Ala Leu Ala Val Val Thr His Ala His Gln Asp Lys Met Gly Gly 
        115                 120                 125             


Met Asp Ala Leu His Ala Ala Gly Ile Ala Thr Tyr Ala Asn Ala Leu 
    130                 135                 140                 


Ser Asn Gln Leu Ala Pro Gln Glu Gly Met Val Ala Ala Gln His Ser 
145                 150                 155                 160 


Leu Thr Phe Ala Ala Asn Gly Trp Val Glu Pro Ala Thr Ala Pro Asn 
                165                 170                 175     


Phe Gly Pro Leu Lys Val Phe Tyr Pro Gly Pro Gly His Thr Ser Asp 
            180                 185                 190         


Asn Ile Thr Val Gly Ile Asp Gly Thr Asp Ile Ala Phe Gly Gly Cys 
        195                 200                 205             


Leu Ile Lys Asp Ser Lys Ala Lys Ser Leu Gly Asn Leu Gly Asp Ala 
    210                 215                 220                 


Asp Thr Glu His Tyr Ala Ala Ser Ala Arg Ala Phe Gly Ala Ala Phe 
225                 230                 235                 240 


Pro Lys Ala Ser Met Ile Val Met Ser His Ser Ala Pro Asp Ser Arg 
                245                 250                 255     


Ala Ala Ile Thr His Thr Ala Arg Met Ala Asp Lys Leu Arg 
            260                 265                 270 


<210>  34
<211>  293
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  34

Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro 
1               5                   10                  15      


Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro 
            20                  25                  30          


Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala 
        35                  40                  45              


Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg 
    50                  55                  60                  


Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu 
65                  70                  75                  80  


Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr 
                85                  90                  95      


Gly Lys Asn Ala Leu Val Arg Trp Ser Pro Ile Ser Glu Lys Tyr Leu 
            100                 105                 110         


Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr 
        115                 120                 125             


Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro 
    130                 135                 140                 


Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg 
145                 150                 155                 160 


Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala 
                165                 170                 175     


Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu 
            180                 185                 190         


Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp 
        195                 200                 205             


Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val 
    210                 215                 220                 


Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Gly Tyr 
225                 230                 235                 240 


Gly Thr Ala Asn Asp Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro 
                245                 250                 255     


Ile Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys His 
            260                 265                 270         


Ser Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu 
        275                 280                 285             


Gly Val Asn Gly Gln 
    290             


<210>  35
<211>  266
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  35

Met Leu Lys Val Ile Ser Ser Leu Leu Val Tyr Met Thr Ala Ser Val 
1               5                   10                  15      


Met Ala Val Ala Ser Pro Leu Ala His Ser Gly Glu Pro Ser Gly Glu 
            20                  25                  30          


Tyr Pro Thr Val Asn Glu Ile Pro Val Gly Glu Val Arg Leu Tyr Gln 
        35                  40                  45              


Ile Ala Asp Gly Val Trp Ser His Ile Ala Thr Gln Ser Phe Asp Gly 
    50                  55                  60                  


Ala Val Tyr Pro Ser Asn Gly Leu Ile Val Arg Asp Gly Asp Glu Leu 
65                  70                  75                  80  


Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys Asn Thr Ala Ala Leu Leu 
                85                  90                  95      


Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ala Val Ser 
            100                 105                 110         


Thr His Phe His Asp Asp Arg Val Gly Gly Val Asp Val Leu Arg Ala 
        115                 120                 125             


Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Thr Arg Arg Leu Ala Glu 
    130                 135                 140                 


Ala Glu Gly Asn Glu Ile Pro Thr His Ser Leu Glu Gly Leu Ser Ser 
145                 150                 155                 160 


Ser Gly Asp Ala Val Arg Phe Gly Pro Val Glu Leu Phe Tyr Pro Gly 
                165                 170                 175     


Ala Ala His Ser Thr Asp Asn Leu Val Val Tyr Val Pro Ser Ala Asn 
            180                 185                 190         


Val Leu Tyr Gly Gly Cys Ala Val His Glu Leu Ser Ser Thr Ser Ala 
        195                 200                 205             


Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Thr Ser Val Glu 
    210                 215                 220                 


Arg Ile Gln Lys His Tyr Pro Glu Ala Glu Val Val Ile Pro Gly His 
225                 230                 235                 240 


Gly Leu Pro Gly Gly Leu Asp Leu Leu Gln His Thr Ala Asn Val Val 
                245                 250                 255     


Lys Ala His Lys Asn Arg Ser Val Ala Glu 
            260                 265     


<210>  36
<211>  265
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  36

Met Arg Val Leu Ala Leu Ser Ala Val Phe Leu Val Ala Ser Ile Ile 
1               5                   10                  15      


Gly Met Pro Ala Val Ala Lys Glu Trp Gln Glu Asn Lys Ser Trp Asn 
            20                  25                  30          


Ala His Phe Thr Glu His Lys Ser Gln Gly Val Val Val Leu Trp Asn 
        35                  40                  45              


Glu Asn Lys Gln Gln Gly Phe Thr Asn Asn Leu Lys Arg Ala Asn Gln 
    50                  55                  60                  


Ala Phe Leu Pro Ala Ser Thr Phe Lys Ile Pro Asn Ser Leu Ile Ala 
65                  70                  75                  80  


Leu Asp Leu Gly Val Val Lys Asp Glu His Gln Val Phe Lys Trp Asp 
                85                  90                  95      


Gly Gln Thr Arg Asp Ile Ala Thr Trp Asn Arg Asp His Asn Leu Ile 
            100                 105                 110         


Thr Ala Met Lys Tyr Ser Val Val Pro Val Tyr Gln Glu Phe Ala Arg 
        115                 120                 125             


Gln Ile Gly Glu Ala Arg Met Ser Lys Met Leu His Ala Phe Asp Tyr 
    130                 135                 140                 


Gly Asn Glu Asp Ile Ser Gly Asn Val Asp Ser Phe Trp Leu Asp Gly 
145                 150                 155                 160 


Gly Ile Arg Ile Ser Ala Thr Glu Gln Ile Ser Phe Leu Arg Lys Leu 
                165                 170                 175     


Tyr His Asn Lys Leu His Val Ser Glu Arg Ser Gln Arg Ile Val Lys 
            180                 185                 190         


Gln Ala Met Leu Thr Glu Ala Asn Gly Asp Tyr Ile Ile Arg Ala Lys 
        195                 200                 205             


Thr Gly Tyr Ser Thr Arg Ile Glu Pro Lys Ile Gly Trp Trp Val Gly 
    210                 215                 220                 


Trp Val Glu Leu Asp Asp Asn Val Trp Phe Phe Ala Met Asn Met Asp 
225                 230                 235                 240 


Met Pro Thr Ser Asp Gly Leu Gly Leu Arg Gln Ala Ile Thr Lys Glu 
                245                 250                 255     


Val Leu Lys Gln Glu Lys Ile Ile Pro 
            260                 265 


