               SEQUENCE LISTING

<110> Sanofi Pasteur SA

<120> Neisseria meningitidis trypsin-like serine protease polypeptides and compositions thereof

<130> IDM1478

<160> 6

<170> BiSSAP 1.2

<210> 1
<211> 1815
<212> PRT
<213> Neisseria meningitidis


<400> 1
Met Lys Thr Lys Arg Phe Lys Ile Asn Ala Ile Ser Leu Ser Ile Phe 
1               5                   10                  15      
Leu Ala Tyr Ala Leu Thr Pro Tyr Ser Glu Ala Ala Leu Val Arg Asp 
            20                  25                  30          
Asp Val Asp Tyr Gln Ile Phe Arg Asp Phe Ala Glu Asn Lys Gly Lys 
        35                  40                  45              
Phe Phe Val Gly Ala Thr Asp Leu Ser Val Lys Asn Lys Gln Gly Gln 
    50                  55                  60                  
Asn Ile Gly Asn Ala Leu Ser Asn Val Pro Met Ile Asp Phe Ser Val 
65                  70                  75                  80  
Ala Asp Val Asn Arg Arg Thr Leu Thr Val Ile Asp Pro Gln Tyr Ala 
                85                  90                  95      
Val Ser Val Lys His Val Lys Gly Asp Glu Ile Ser Tyr Tyr Gly His 
            100                 105                 110         
His Asn Gly His Leu Asp Val Ser Asn Asp Glu Asn Glu Tyr Arg Ser 
        115                 120                 125             
Val Ala Gln Asn Asp Tyr Glu Pro Asn Lys Asn Trp His His Gly Asn 
    130                 135                 140                 
Gln Gly Arg Leu Glu Asp Tyr Asn Met Ala Arg Leu Asn Lys Phe Val 
145                 150                 155                 160 
Thr Glu Val Ala Pro Ile Ala Pro Thr Ser Ala Gly Gly Gly Val Glu 
                165                 170                 175     
Thr Tyr Lys Asp Lys Asn Arg Phe Ser Glu Phe Val Arg Val Gly Ala 
            180                 185                 190         
Gly Thr Gln Phe Glu Tyr Asn Ser Arg Tyr Asn Met Thr Glu Leu Ser 
        195                 200                 205             
Arg Ala Tyr Arg Tyr Ala Ile Ala Gly Thr Pro Tyr Gln Asp Val Asn 
    210                 215                 220                 
Val Thr Ser Asn Leu Asn Gln Glu Gly Leu Ile Gly Phe Gly Asp Asn 
225                 230                 235                 240 
Ser Lys His His Ser Pro Glu Lys Leu Lys Glu Val Leu Ser Gln Asn 
                245                 250                 255     
Ala Leu Thr Asn Tyr Ala Val Leu Gly Asp Ser Gly Ser Pro Leu Phe 
            260                 265                 270         
Ala Tyr Asp Lys Gln Glu Lys Arg Trp Val Phe Leu Gly Ala Tyr Asp 
        275                 280                 285             
Tyr Trp Ala Gly Tyr Gln Lys Asn Ser Trp Gln Glu Trp Asn Ile Tyr 
    290                 295                 300                 
Lys Lys Glu Phe Ala Asp Glu Ile Lys Gln Arg Asp Asn Ala Gly Thr 
305                 310                 315                 320 
Ile Lys Gly Asn Gly Glu His His Trp Lys Thr Thr Gly Thr Asn Ser 
                325                 330                 335     
His Ile Gly Ser Thr Ala Val Arg Leu Ala Asn Asn Glu Arg Asp Ala 
            340                 345                 350         
Asn Asn Gly Gln Asn Val Thr Phe Glu Asn Asn Gly Thr Leu Val Leu 
        355                 360                 365             
Asp Gln Asn Ile Asn Gln Gly Ala Gly Gly Leu Phe Phe Lys Gly Asp 
    370                 375                 380                 
Tyr Thr Val Lys Gly Ile Asn Asn Asp Ile Thr Trp Leu Gly Ala Gly 
385                 390                 395                 400 
Ile Asp Val Ala Asp Gly Lys Lys Val Val Trp Gln Val Lys Asn Pro 
                405                 410                 415     
Asn Gly Asp Arg Leu Ala Lys Ile Gly Lys Gly Thr Leu Glu Ile Asn 
            420                 425                 430         
Gly Thr Gly Val Asn Gln Gly Gln Leu Lys Val Gly Asp Gly Thr Val 
        435                 440                 445             
Ile Leu Asn Gln Gln Ala Asp Ala Asp Lys Lys Val Gln Ala Phe Ser 
    450                 455                 460                 
Gln Val Gly Ile Val Ser Gly Arg Gly Thr Leu Val Leu Asn Ser Ser 
465                 470                 475                 480 
Asn Gln Ile Asn Pro Asp Asn Leu Tyr Phe Gly Phe Arg Gly Gly Arg 
                485                 490                 495     
Leu Asp Ala Asn Gly Asn Asp Leu Thr Phe Glu His Ile Arg Asn Val 
            500                 505                 510         
Asp Glu Gly Ala Arg Ile Val Asn His Asn Thr Gly His Ala Ser Thr 
        515                 520                 525             
Ile Thr Leu Thr Gly Lys Ser Leu Ile Thr Asp Pro Lys Thr Ile Ser 
    530                 535                 540                 
Ile His Tyr Ile Gln Asn Asn Asp Asp Asp Asp Ala Gly Tyr Tyr Tyr 
545                 550                 555                 560 
Tyr Arg Pro Arg Lys Pro Ile Pro Gln Gly Lys Asp Leu Tyr Phe Lys 
                565                 570                 575     
Asn Tyr Arg Tyr Tyr Ala Leu Lys Ser Gly Gly Ser Val Asn Ala Pro 
            580                 585                 590         
Met Pro Glu Asn Gly Gln Thr Glu Asn Asn Asp Trp Ile Leu Met Gly 
        595                 600                 605             
Ser Thr Gln Glu Glu Ala Lys Lys Asn Ala Met Asn His Lys Asn Asn 
    610                 615                 620                 
Gln Arg Ile Ser Gly Phe Ser Gly Phe Phe Gly Glu Glu Asn Gly Lys 
625                 630                 635                 640 
Gly His Asn Gly Ala Leu Asn Leu Asn Phe Asn Gly Lys Ser Ala Gln 
                645                 650                 655     
Asn Arg Phe Leu Leu Thr Gly Gly Thr Asn Leu Asn Gly Lys Ile Ser 
            660                 665                 670         
Val Thr Gln Gly Asn Val Leu Leu Ser Gly Arg Pro Thr Pro His Ala 
        675                 680                 685             
Arg Asp Phe Val Asn Lys Ser Ser Ala Arg Lys Asp Ala His Phe Ser 
    690                 695                 700                 
Lys Asn Asn Glu Val Val Phe Glu Asp Asp Trp Ile Asn Arg Thr Phe 
705                 710                 715                 720 
Lys Ala Thr Glu Ile Ala Val Asn Gln Ser Ala Ser Phe Ser Ser Gly 
                725                 730                 735     
Arg Asn Val Ser Asp Ile Thr Ala Asn Ile Thr Ala Thr Asp Asn Ala 
            740                 745                 750         
Lys Val Asn Leu Gly Tyr Lys Asn Gly Asp Glu Val Cys Val Arg Ser 
        755                 760                 765             
Asp Tyr Thr Gly Tyr Val Thr Cys Asn Thr Gly Asn Leu Ser Asp Lys 
    770                 775                 780                 
Ala Leu Asn Ser Phe Gly Ala Thr Gln Ile Asn Gly Asn Val Asn Leu 
785                 790                 795                 800 
Asn Gln Asn Ala Ala Leu Val Leu Gly Lys Ala Ala Leu Trp Gly Gln 
                805                 810                 815     
Ile Gln Gly Gln Gly Asn Ser Arg Val Ser Leu Asn Gln His Ser Lys 
            820                 825                 830         
Trp His Leu Thr Gly Asp Ser Gln Val His Asn Leu Ser Leu Ala Asp 
        835                 840                 845             
Ser His Ile His Leu Asn Asn Ala Ser Asp Ala Gln Ser Ala Asn Lys 
    850                 855                 860                 
Tyr His Thr Leu Lys Ile Asn His Leu Ser Gly Asn Gly His Phe His 
865                 870                 875                 880 
Tyr Leu Thr His Leu Ala Lys Asn Leu Gly Asp Lys Val Leu Val Lys 
                885                 890                 895     
Glu Ser Ala Ser Gly His Tyr Gln Leu His Val Gln Asp Lys Thr Gly 
            900                 905                 910         
Glu Pro Asn Gln Glu Gly Leu Asn Leu Phe Asp Ala Ser Ser Val Gln 
        915                 920                 925             
Asp Arg Ser Arg Leu Ser Val Ser Leu Ala Asn Asn His Val Asp Leu 
    930                 935                 940                 
Gly Ala Leu Arg Tyr Thr Ile Lys Thr Glu Asn Gly Ile Thr Arg Leu 
945                 950                 955                 960 
Tyr Asn Pro Tyr Ala Glu Asn Arg Arg Arg Val Lys Pro Ala Pro Ser 
                965                 970                 975     
Pro Ala Thr Asn Thr Ala Ser Gln Ala Gln Lys Ala Thr Gln Thr Asp 
            980                 985                 990         
Gly Ala Gln Ile Ala Lys Pro Gln Asn Ile Val Val Ala Pro Pro Ser 
        995                 1000                1005            
Pro Gln Ala Asn Gln Ala Glu Glu Ala Lys Arg Gln Gln Ala Lys Ala 
    1010                1015                1020                
Glu Gln Val Lys Arg Gln Gln Ala Glu Ala Glu Arg Lys Ser Ala Glu 
1025                1030                1035                1040
Leu Ala Lys Gln Lys Ala Glu Ala Glu Arg Glu Ala Arg Glu Leu Ala 
                1045                1050                1055    
Thr Arg Gln Lys Ala Glu Gln Glu Arg Ser Ser Ala Glu Leu Ala Arg 
            1060                1065                1070        
Arg His Glu Lys Glu Arg Glu Ala Ala Glu Leu Ser Ala Lys Gln Lys 
        1075                1080                1085            
Val Glu Ala Glu Arg Glu Ala Gln Ala Leu Ala Val Arg Arg Lys Ala 
    1090                1095                1100                
Glu Ala Glu Glu Ala Lys Arg Gln Ala Ala Glu Leu Ala Arg Arg His 
1105                1110                1115                1120
Glu Lys Glu Arg Glu Ala Ala Glu Leu Ser Ala Lys Gln Arg Val Gly 
                1125                1130                1135    
Glu Glu Glu Arg Arg Gln Thr Ala Gln Ser Gln Pro Gln Arg Arg Lys 
            1140                1145                1150        
Arg Arg Ala Ala Pro Gln Asp Tyr Met Ala Ala Ser Gln Asp Arg Pro 
        1155                1160                1165            
Lys Arg Arg Gly His Arg Ser Val Gln Gln Asn Asn Val Glu Ile Ala 
    1170                1175                1180                
Gln Ala Gln Ala Glu Leu Ala Arg Arg Gln Gln Glu Glu Arg Lys Ala 
1185                1190                1195                1200
Ala Glu Leu Leu Ala Lys Gln Arg Ala Glu Ala Glu Arg Glu Ala Gln 
                1205                1210                1215    
Ala Leu Ala Ala Arg Arg Lys Ala Glu Ala Glu Glu Ala Lys Arg Gln 
            1220                1225                1230        
Ala Ala Glu Leu Ala His Arg Gln Glu Ala Glu Arg Lys Ala Ala Glu 
        1235                1240                1245            
Leu Ser Ala Asn Gln Lys Ala Ala Ala Glu Ala Gln Ala Leu Ala Ala 
    1250                1255                1260                
Arg Gln Gln Lys Ala Leu Ala Arg Gln Gln Glu Glu Ala Arg Lys Ala 
1265                1270                1275                1280
Ala Glu Leu Ala Val Lys Gln Lys Ala Glu Thr Glu Arg Lys Thr Ala 
                1285                1290                1295    
Glu Leu Ala Lys Gln Arg Ala Ala Ala Glu Ala Ala Lys Arg Gln Gln 
            1300                1305                1310        
Glu Ala Arg Gln Thr Ala Glu Leu Ala Arg Arg Gln Glu Ala Glu Arg 
        1315                1320                1325            
Gln Ala Ala Glu Leu Ser Ala Lys Gln Lys Ala Glu Thr Asp Arg Glu 
    1330                1335                1340                
Ala Ala Glu Ser Ala Lys Arg Lys Ala Glu Glu Glu Glu His Arg Gln 
1345                1350                1355                1360
Ala Ala Gln Ser Gln Pro Gln Arg Arg Lys Arg Arg Ala Ala Pro Gln 
                1365                1370                1375    
Asp Tyr Met Ala Ala Ser Gln Asn Arg Pro Lys Arg Arg Gly Arg Arg 
            1380                1385                1390        
Ser Thr Leu Pro Ala Pro Pro Ser Pro Ser Phe Asp Ser Ser Ala Tyr 
        1395                1400                1405            
Ala Ala Pro Arg Ala Leu His Asn Pro Asp Trp Tyr Glu Asn Asp Tyr 
    1410                1415                1420                
Glu Glu Ile Pro Leu Asp Ala Leu Glu Asp Glu Asn Val Ser Glu Ser 
1425                1430                1435                1440
Val Asp Thr Ser Asp Lys Gln Pro Gln Asp Asn Thr Glu Leu His Glu 
                1445                1450                1455    
Lys Tyr Glu Asn Asp Tyr Glu Glu Ile Pro Leu Asp Ala Leu Glu Asp 
            1460                1465                1470        
Glu Asp Val Ser Glu Ser Val Asp Thr Ser Asp Lys Gln Pro Gln Asp 
        1475                1480                1485            
Asn Thr Glu Leu His Glu Lys Val Glu Thr Val Ser Leu Gln Pro Arg 
    1490                1495                1500                
Ala Ala Gln Pro Arg Ala Gln Ala Ala Thr Gln Leu Gln Ala Gln Ala 
1505                1510                1515                1520
Ala Ala Gln Ala Asp Ala Val Ser Thr Asn Thr Asn Ser Ala Leu Ser 
                1525                1530                1535    
Asp Ala Met Ala Ser Thr Gln Ser Ile Leu Leu Asp Thr Gly Ala Ser 
            1540                1545                1550        
Leu Thr Arg His Ile Ala Gln Lys Ser Arg Ala Asp Ala Glu Lys Asn 
        1555                1560                1565            
Ser Val Trp Met Ser Asn Thr Gly Tyr Gly Arg Asp Tyr Ala Ser Ala 
    1570                1575                1580                
Gln Tyr Arg Arg Phe Ser Ser Lys Arg Thr Gln Thr Gln Ile Gly Ile 
1585                1590                1595                1600
Asp Arg Ser Leu Ser Glu Asn Met Gln Ile Gly Gly Val Leu Thr Tyr 
                1605                1610                1615    
Ser Asp Ser Gln His Thr Phe Asp Gln Ala Ser Gly Lys Asn Thr Phe 
            1620                1625                1630        
Val Gln Ala Asn Leu Tyr Gly Lys Tyr Tyr Leu Asn Asp Ala Trp Tyr 
        1635                1640                1645            
Val Ala Gly Asp Ile Gly Ala Gly Ser Leu Arg Ser Arg Leu Gln Thr 
    1650                1655                1660                
Gln Gln Lys Ala Asn Phe Asn Arg Ala Ser Ile Gln Thr Gly Leu Thr 
1665                1670                1675                1680
Leu Gly Asn Thr Leu Lys Ile Asn Gln Phe Glu Ile Val Pro Ser Ala 
                1685                1690                1695    
Gly Ile Arg Tyr Ser Arg Leu Ser Ser Ala Asp Tyr Lys Leu Gly Asn 
            1700                1705                1710        
Asp Ser Val Lys Val Ser Ser Met Ser Val Lys Thr Leu Thr Ala Gly 
        1715                1720                1725            
Leu Asp Phe Ala Tyr Arg Phe Lys Val Gly Asn Leu Thr Val Lys Pro 
    1730                1735                1740                
Leu Leu Ser Ala Ala Tyr Phe Ala Asn Tyr Gly Lys Gly Gly Val Asn 
1745                1750                1755                1760
Val Gly Gly Asn Ser Phe Val Tyr Lys Ala Asp Asn Gln Gln Gln Tyr 
                1765                1770                1775    
Ser Ala Gly Ala Ala Leu Leu Tyr Arg Asn Val Thr Leu Asn Val Asn 
            1780                1785                1790        
Gly Ser Ile Thr Lys Gly Lys Gln Leu Glu Lys Gln Lys Ser Gly Gln 
        1795                1800                1805            
Ile Lys Ile Gln Ile Arg Phe 
    1810                1815

<210> 2
<211> 5448
<212> DNA
<213> Neisseria meningitidis

<220> 
<221> source
<222> 1..5448
<223> /mol_type="unassigned DNA"
      /organism="Neisseria meningitidis"

<400> 2
atgaaaacca aacgttttaa aattaacgcc atatccttat ccatctttct tgcctatgcc       60

cttacgccat actcagaagc ggcattggtc agagacgatg tcgattatca aatattccgt      120

gactttgcag aaaacaaagg caaatttttt gtcggcgcaa ccgatttatc agtgaaaaac      180

aaacaaggtc aaaacatcgg caacgcatta tccaacgtac cgatgattga ttttagcgtt      240

gcagatgtca acagacgtac attaaccgtc atcgatcccc agtatgccgt cagcgtcaaa      300

catgtaaaag gagacgaaat ctcttattac gggcatcaca atgggcactt agatgttagc      360

aatgatgaaa acgaatatcg ttcagttgca caaaatgact acgaaccaaa taaaaattgg      420

catcacggta atcaaggtcg tcttgaagac tacaacatgg cacgccttaa taaattcgta      480

acagaagtcg cacctattgc accaaccagt gcaggcggcg gcgttgaaac ctataaagat      540

aaaaaccgtt tttctgagtt tgtgcgagtt ggagcaggta cgcaatttga atataacagc      600

cgctacaata tgacagagct ttcacgagct tatcgttatg ccattgcagg tacgccttat      660

caagacgtga atgtcacatc gaatctaaat caagaaggct tgattggctt cggtgataat      720

tcaaaacatc attccccaga aaaactcaaa gaagttttat ctcaaaacgc attgactaac      780

tatgctgtgt taggcgatag cggttcacca ttatttgctt atgataaaca agaaaaacgc      840

tgggtctttt taggtgctta cgattattgg gcaggctatc aaaaaaactc ttggcaagaa      900

tggaatatct ataaaaaaga atttgcagat gaaatcaaac aacgcgataa cgccggcacc      960

atcaaaggta atggagaaca tcattggaaa accacgggca caaacagcca tatcggttcg     1020

acagcggtaa ggcttgccaa caatgaaagg gatgcaaaca acggacagaa tgttaccttt     1080

gaaaacaacg gcactttggt attggatcaa aacatcaacc aaggcgcggg cggtctgttt     1140

ttcaaaggcg attacacagt caaaggtata aataatgaca tcacttggct aggtgcgggg     1200

attgatgttg ccgacggcaa aaaagtcgtt tggcaagtca aaaatccgaa tggcgacaga     1260

ttggcaaaaa tcggcaaagg cacattagaa ataaacggca caggcgttaa ccaagggcaa     1320

ttaaaagtcg gcgacggtac ggttattctg aatcaacaag ccgatgccga caaaaaagtc     1380

caggctttct cccaagtcgg cattgtcagc ggacgcggta cattggtatt aaatagttca     1440

aatcagatta atcccgataa cctatatttc ggtttccgtg gcggtcgttt ggatgccaat     1500

ggcaatgact tgacttttga acacatccgc aacgtggatg aaggcgcgcg cattgtcaac     1560

cacaacacag gccacgcctc cacaatcacg ctaacgggta aatctttgat taccgatccc     1620

aaaaccatct ctattcatta tattcaaaat aatgatgatg acgatgctgg ttattactat     1680

taccgcccta ggaaaccgat tccacaaggc aaagatcttt atttcaaaaa ctaccgttat     1740

tacgccctaa aatccggcgg cagcgtgaac gcaccgatgc ccgaaaacgg acaaacggaa     1800

aataacgact ggattttaat gggcagcaca caagaagaag ccaagaaaaa cgcgatgaac     1860

cacaaaaaca atcagcgtat tagcggtttt agcggtttct ttggcgaaga aaacggaaaa     1920

ggacataacg gtgcattaaa ccttaatttc aacggcaaaa gcgcgcaaaa ccgtttcttg     1980

ttaacaggcg gcactaattt aaacggaaaa ataagcgtaa ctcaaggcaa tgtcttgtta     2040

tcaggtcgtc caacaccaca cgcaagagat tttgtgaaca aatcttcagc ccgaaaagac     2100

gcacatttct ccaaaaacaa tgaagtcgta tttgaagacg actggataaa ccgcacattc     2160

aaagccacag aaattgcggt taatcaatcc gcatcattct cttccggcag aaatgtatcc     2220

gacatcaccg ccaacatcac cgcaacagac aacgccaaag taaatttggg ttacaaaaac     2280

ggcgatgagg tttgcgtgcg ctcggactat accggttacg ttacctgcaa cacaggcaac     2340

ttatccgata aggctttaaa cagctttgga gcgacacaga ttaacggcaa tgtgaatctg     2400

aaccagaatg cggcattggt cttgggcaag gctgcattat gggggcaaat tcaagggcaa     2460

ggaaacagcc gtgtcagcct aaaccaacat agcaaatggc atttgaccgg cgacagccaa     2520

gtacacaatc tgtcattggc ggatagccat attcatttga acaatgcctc cgatgcgcaa     2580

agtgcaaata aataccacac gctcaaaatc aatcatttat ccggtaacgg gcattttcat     2640

tatctgacgc acctggcgaa aaatcttggg gataaagtgc ttgtgaagga atccgcatcc     2700

ggtcattatc agctccatgt tcaagataaa acaggcgaac ccaatcagga agggctgaat     2760

ctctttgatg catcatccgt acaagaccgc tcccgccttt ctgtttcctt ggcgaataac     2820

catgtagatt taggggcatt gcgttataca atcaaaacag aaaacggtat tacccgattg     2880

tacaatcctt atgccgagaa ccgccgccga gtcaaaccgg ccccgtctcc tgccacaaac     2940

acggcttctc aagcacaaaa ggcaacacaa acggacggtg cacaaattgc caagcctcaa     3000

aatatcgtcg tcgcaccgcc tagcccgcag gcaaatcaag ccgaagaagc aaaacgccag     3060

caagcaaaag cggagcaagt gaagcgtcag caagcagaag cagagcgtaa atcggcagag     3120

ttagcaaaac aaaaagcaga agccgaacgc gaagcaagag agctggcgac ccgccaaaaa     3180

gcagaacaag aacgcagcag cgccgaactt gcacgtcgac atgaaaaaga acgcgaagcg     3240

gcagagttgt cggcaaaaca aaaagtcgaa gccgaacgtg aggctcaagc attggcggta     3300

cgccgaaaag cagaagccga agaggcaaaa cgccaagctg cagagcttgc acgccggcat     3360

gaaaaagaac gcgaagcggc agagttgtcg gcaaaacaaa gggtcgggga agaggaacgc     3420

cgtcaaacag cccaatccca gccgcaacgc cgcaaacgcc gtgccgcacc gcaggattat     3480

atggcagctt cccaagaccg tcctaaacgc cgcggacacc gttcggtaca gcaaaacaat     3540

gtggaaattg cccaagccca agcagaactt gcgcgccgac agcaggaaga acgcaaagcg     3600

gcagagttgt tggcaaaaca aagggcagaa gccgaacgtg aagctcaagc attggctgcg     3660

cgccgaaaag cagaagccga agaggcaaaa cgccaagctg ccgaacttgc acatcgccag     3720

gaagcagaac gcaaagcggc agaattgtcg gcaaaccaaa aagccgcagc tgaagcccaa     3780

gcattggcgg cacgccaaca aaaagccctt gcgcgtcaac aggaagaagc acgaaaagct     3840

gcagagttag ccgtcaaaca aaaagcggaa accgaacgca aaaccgccga acttgccaag     3900

caaagggcag cagccgaagc agcaaaacgc cagcaagaag ctcgccagac cgccgaactt     3960

gcacgtcgtc aagaagcgga acgccaagca gcagagttgt cggcaaaaca aaaagccgaa     4020

acagatcgag aagcggcaga atcggcgaaa cgaaaagctg aggaagaaga gcaccgtcaa     4080

gcagcccaat cccagccgca acgccgaaaa cgccgtgccg cacctcagga ttatatggca     4140

gcttcccaaa atcgtccgaa acgtcgcgga cgcagatcta ctctgccggc accgccctcg     4200

ccatcatttg attcgtcagc ttacgcagca cccagggcct tgcataatcc ggactggtat     4260

gaaaatgact atgaagaaat ccccttggat gcgttggaag atgaaaatgt atctgaatca     4320

gttgacacat cagacaaaca gcctcaagac aatacggaac ttcatgaaaa atatgaaaat     4380

gattatgaag aaatcccctt ggatgcgttg gaagatgaag atgtatccga atcggttgac     4440

acatcagaca aacagcctca agacaatacg gaacttcatg aaaaagttga gacagtgagt     4500

ttgcaaccaa gagccgcgca gccgcgagcc caagccgcca ctcagctgca agcccaagcc     4560

gccgcgcaag ccgatgcagt cagcaccaat accaactcgg ctttatctga cgcaatggca     4620

agcacgcaat ctatcttgtt ggatacaggt gcttcattaa cacggcacat tgcacaaaaa     4680

tcacgcgctg atgccgaaaa aaacagtgtt tggatgtcga acaccggtta tggtcgtgat     4740

tatgcttccg cacaatatcg ccggtttagt tcgaaacgca cgcaaacaca aatcggcatt     4800

gaccgcagct tgtccgaaaa tatgcagata ggcggcgtat tgacttactc tgacagtcag     4860

catacttttg atcaggcgag cggcaaaaat acttttgtgc aagccaacct ttatggtaag     4920

tattatttaa atgatgcttg gtatgtggcc ggcgatattg gtgcaggcag cttgagaagc     4980

cggttacaaa cgcagcaaaa agcaaacttt aaccgagcaa gcatccaaac cggccttact     5040

ttgggcaata cgctgaaaat caatcaattc gagattgtcc ccagtgcggg gatccgttac     5100

agccgcctgt catctgcaga ttacaagttg ggtaacgaca gtgttaaagt aagttctatg     5160

tcagtgaaaa cactaacggc cggactggat tttgcttatc ggtttaaagt cggcaacctt     5220

accgtaaaac ccttgttatc tgcagcttac tttgccaatt atggcaaagg cggcgtgaat     5280

gtgggcggta attccttcgt ctataaagca gataatcaac agcaatattc agcaggtgcc     5340

gcgttactgt accgtaatgt tacattaaac gtaaatggca gtattacaaa aggaaaacaa     5400

ttggaaaaac aaaaatccgg acaaattaaa atacagattc gtttctaa                  5448


<210> 3
<211> 1457
<212> PRT
<213> Neisseria meningitidis


<400> 3
Met Lys Thr Thr Asp Lys Arg Thr Thr Glu Thr His Arg Lys Ala Pro 
1               5                   10                  15      
Lys Thr Gly Arg Ile Arg Phe Ser Pro Ala Tyr Leu Ala Ile Cys Leu 
            20                  25                  30          
Ser Phe Gly Ile Leu Pro Gln Ala Trp Ala Gly His Thr Tyr Phe Gly 
        35                  40                  45              
Ile Asn Tyr Gln Tyr Tyr Arg Asp Phe Ala Glu Asn Lys Gly Lys Phe 
    50                  55                  60                  
Ala Val Gly Ala Lys Asp Ile Glu Val Tyr Asn Lys Lys Gly Glu Leu 
65                  70                  75                  80  
Val Gly Lys Ser Met Thr Lys Ala Pro Met Ile Asp Phe Ser Val Val 
                85                  90                  95      
Ser Arg Asn Gly Val Ala Ala Leu Val Gly Asp Gln Tyr Ile Val Ser 
            100                 105                 110         
Val Ala His Asn Gly Gly Tyr Asn Asn Val Asp Phe Gly Ala Glu Gly 
        115                 120                 125             
Arg Asn Pro Asp Gln His Arg Phe Thr Tyr Lys Ile Val Lys Arg Asn 
    130                 135                 140                 
Asn Tyr Lys Ala Gly Thr Lys Gly His Pro Tyr Gly Gly Asp Tyr His 
145                 150                 155                 160 
Met Pro Arg Leu His Lys Phe Val Thr Asp Ala Glu Pro Val Glu Met 
                165                 170                 175     
Thr Ser Tyr Met Asp Gly Arg Lys Tyr Ile Asp Gln Asn Asn Tyr Pro 
            180                 185                 190         
Asp Arg Val Arg Ile Gly Ala Gly Arg Gln Tyr Trp Arg Ser Asp Glu 
        195                 200                 205             
Asp Glu Pro Asn Asn Arg Glu Ser Ser Tyr His Ile Ala Ser Ala Tyr 
    210                 215                 220                 
Ser Trp Leu Val Gly Gly Asn Thr Phe Ala Gln Asn Gly Ser Gly Gly 
225                 230                 235                 240 
Gly Thr Val Asn Leu Gly Ser Glu Lys Ile Lys His Ser Pro Tyr Gly 
                245                 250                 255     
Phe Leu Pro Thr Gly Gly Ser Phe Gly Asp Ser Gly Ser Pro Met Phe 
            260                 265                 270         
Ile Tyr Asp Ala Gln Lys Gln Lys Trp Leu Ile Asn Gly Val Leu Gln 
        275                 280                 285             
Thr Gly Asn Pro Tyr Ile Gly Lys Ser Asn Gly Phe Gln Leu Val Arg 
    290                 295                 300                 
Lys Asp Trp Phe Tyr Asp Glu Ile Phe Ala Gly Asp Thr His Ser Val 
305                 310                 315                 320 
Phe Tyr Glu Pro Arg Gln Asn Gly Lys Tyr Ser Phe Asn Asp Asp Asn 
                325                 330                 335     
Asn Gly Thr Gly Lys Ile Asn Ala Lys His Glu His Asn Ser Leu Pro 
            340                 345                 350         
Asn Arg Leu Lys Thr Arg Thr Val Gln Leu Phe Asn Val Ser Leu Ser 
        355                 360                 365             
Glu Thr Ala Arg Glu Pro Val Tyr His Ala Ala Gly Gly Val Asn Ser 
    370                 375                 380                 
Tyr Arg Pro Arg Leu Asn Asn Gly Glu Asn Ile Ser Phe Ile Asp Glu 
385                 390                 395                 400 
Gly Lys Gly Glu Leu Ile Leu Thr Ser Asn Ile Asn Gln Gly Ala Gly 
                405                 410                 415     
Gly Leu Tyr Phe Gln Gly Asp Phe Thr Val Ser Pro Glu Asn Asn Glu 
            420                 425                 430         
Thr Trp Gln Gly Ala Gly Val His Ile Ser Glu Asp Ser Thr Val Thr 
        435                 440                 445             
Trp Lys Val Asn Gly Val Ala Asn Asp Arg Leu Ser Lys Ile Gly Lys 
    450                 455                 460                 
Gly Thr Leu His Val Gln Ala Lys Gly Glu Asn Gln Gly Ser Ile Ser 
465                 470                 475                 480 
Val Gly Asp Gly Thr Val Ile Leu Asp Gln Gln Ala Asp Asp Lys Gly 
                485                 490                 495     
Lys Lys Gln Ala Phe Ser Glu Ile Gly Leu Val Ser Gly Arg Gly Thr 
            500                 505                 510         
Val Gln Leu Asn Ala Asp Asn Gln Phe Asn Pro Asp Lys Leu Tyr Phe 
        515                 520                 525             
Gly Phe Arg Gly Gly Arg Leu Asp Leu Asn Gly His Ser Leu Ser Phe 
    530                 535                 540                 
His Arg Ile Gln Asn Thr Asp Glu Gly Ala Met Ile Val Asn His Asn 
545                 550                 555                 560 
Gln Asp Lys Glu Ser Thr Val Thr Ile Thr Gly Asn Lys Asp Ile Ala 
                565                 570                 575     
Thr Thr Gly Asn Asn Asn Ser Leu Asp Ser Lys Lys Glu Ile Ala Tyr 
            580                 585                 590         
Asn Gly Trp Phe Gly Glu Lys Asp Thr Thr Lys Thr Asn Gly Arg Leu 
        595                 600                 605             
Asn Leu Val Tyr Gln Pro Ala Ala Glu Asp Arg Thr Leu Leu Leu Ser 
    610                 615                 620                 
Gly Gly Thr Asn Leu Asn Gly Asn Ile Thr Gln Thr Asn Gly Lys Leu 
625                 630                 635                 640 
Phe Phe Ser Gly Arg Pro Thr Pro His Ala Tyr Asn His Leu Asn Asp 
                645                 650                 655     
His Trp Ser Gln Lys Glu Gly Ile Pro Arg Gly Glu Ile Val Trp Asp 
            660                 665                 670         
Asn Asp Trp Ile Asn Arg Thr Phe Lys Ala Glu Asn Phe Gln Ile Lys 
        675                 680                 685             
Gly Gly Gln Ala Val Val Ser Arg Asn Val Ala Lys Val Lys Gly Asp 
    690                 695                 700                 
Trp His Leu Ser Asn His Ala Gln Ala Val Phe Gly Val Ala Pro His 
705                 710                 715                 720 
Gln Ser His Thr Ile Cys Thr Arg Ser Asp Trp Thr Gly Leu Thr Asn 
                725                 730                 735     
Cys Val Glu Lys Thr Ile Thr Asp Asp Lys Val Ile Ala Ser Leu Thr 
            740                 745                 750         
Lys Thr Asp Ile Ser Gly Asn Val Asp Leu Ala Asp His Ala His Leu 
        755                 760                 765             
Asn Leu Thr Gly Leu Ala Thr Leu Asn Gly Asn Leu Ser Ala Asn Gly 
    770                 775                 780                 
Asp Thr Arg Tyr Thr Val Ser His Asn Ala Thr Gln Asn Gly Asn Leu 
785                 790                 795                 800 
Ser Leu Val Gly Asn Ala Gln Ala Thr Phe Asn Gln Ala Thr Leu Asn 
                805                 810                 815     
Gly Asn Thr Ser Ala Ser Gly Asn Ala Ser Phe Asn Leu Ser Asp His 
            820                 825                 830         
Ala Val Gln Asn Gly Ser Leu Thr Leu Ser Gly Asn Ala Lys Ala Asn 
        835                 840                 845             
Val Ser His Ser Ala Leu Asn Gly Asn Val Ser Leu Ala Asp Lys Ala 
    850                 855                 860                 
Val Phe His Phe Glu Ser Ser Arg Phe Thr Gly Gln Ile Ser Gly Gly 
865                 870                 875                 880 
Lys Asp Thr Ala Leu His Leu Lys Asp Ser Glu Trp Thr Leu Pro Ser 
                885                 890                 895     
Gly Thr Glu Leu Gly Asn Leu Asn Leu Asp Asn Ala Thr Ile Thr Leu 
            900                 905                 910         
Asn Ser Ala Tyr Arg His Asp Ala Ala Gly Ala Gln Thr Gly Ser Ala 
        915                 920                 925             
Thr Asp Ala Pro Arg Arg Arg Ser Arg Arg Ser Arg Arg Ser Leu Leu 
    930                 935                 940                 
Ser Val Thr Pro Pro Thr Ser Val Glu Ser Arg Phe Asn Thr Leu Thr 
945                 950                 955                 960 
Val Asn Gly Lys Leu Asn Gly Gln Gly Thr Phe Arg Phe Met Ser Glu 
                965                 970                 975     
Leu Phe Gly Tyr Arg Ser Asp Lys Leu Lys Leu Ala Glu Ser Ser Glu 
            980                 985                 990         
Gly Thr Tyr Thr Leu Ala Val Asn Asn Thr Gly Asn Glu Pro Ala Ser 
        995                 1000                1005            
Leu Glu Gln Leu Thr Val Val Glu Gly Lys Asp Asn Lys Pro Leu Ser 
    1010                1015                1020                
Glu Asn Leu Asn Phe Thr Leu Gln Asn Glu His Val Asp Ala Gly Ala 
1025                1030                1035                1040
Trp Arg Tyr Gln Leu Ile Arg Lys Asp Gly Glu Phe Arg Leu His Asn 
                1045                1050                1055    
Pro Val Lys Glu Gln Glu Leu Ser Asp Lys Leu Gly Lys Ala Glu Ala 
            1060                1065                1070        
Lys Lys Gln Ala Glu Lys Asp Asn Ala Gln Ser Leu Asp Ala Leu Ile 
        1075                1080                1085            
Ala Ala Gly Arg Asp Ala Val Glu Lys Thr Glu Ser Val Ala Glu Pro 
    1090                1095                1100                
Ala Arg Gln Ala Gly Gly Glu Asn Val Gly Ile Met Gln Ala Glu Glu 
1105                1110                1115                1120
Glu Lys Lys Arg Val Gln Ala Asp Lys Asp Thr Ala Leu Ala Lys Gln 
                1125                1130                1135    
Arg Glu Ala Glu Thr Arg Pro Ala Thr Thr Ala Phe Pro Arg Ala Arg 
            1140                1145                1150        
Arg Ala Arg Arg Asp Leu Pro Gln Leu Gln Pro Gln Pro Gln Pro Gln 
        1155                1160                1165            
Pro Gln Arg Asp Leu Ile Ser Arg Tyr Ala Asn Ser Gly Leu Ser Glu 
    1170                1175                1180                
Phe Ser Ala Thr Leu Asn Ser Val Phe Ala Val Gln Asp Glu Leu Asp 
1185                1190                1195                1200
Arg Val Phe Ala Glu Asp Arg Arg Asn Ala Val Trp Thr Ser Gly Ile 
                1205                1210                1215    
Arg Asp Thr Lys His Tyr Arg Ser Gln Asp Phe Arg Ala Tyr Arg Gln 
            1220                1225                1230        
Gln Thr Asp Leu Arg Gln Ile Gly Met Gln Lys Asn Leu Gly Ser Gly 
        1235                1240                1245            
Arg Val Gly Ile Leu Phe Ser His Asn Arg Thr Glu Asn Thr Phe Asp 
    1250                1255                1260                
Asp Gly Ile Gly Asn Ser Ala Arg Leu Ala His Gly Ala Val Phe Gly 
1265                1270                1275                1280
Gln Tyr Gly Ile Asp Arg Phe Tyr Ile Gly Ile Ser Ala Gly Ala Gly 
                1285                1290                1295    
Phe Ser Ser Gly Ser Leu Ser Asp Gly Ile Gly Gly Lys Ile Arg Arg 
            1300                1305                1310        
Arg Val Leu His Tyr Gly Ile Gln Ala Arg Tyr Arg Ala Gly Phe Gly 
        1315                1320                1325            
Gly Phe Gly Ile Glu Pro His Ile Gly Ala Thr Arg Tyr Phe Val Gln 
    1330                1335                1340                
Lys Ala Asp Tyr Arg Tyr Glu Asn Val Asn Ile Ala Thr Pro Gly Leu 
1345                1350                1355                1360
Ala Phe Asn Arg Tyr Arg Ala Gly Ile Lys Ala Asp Tyr Ser Phe Lys 
                1365                1370                1375    
Pro Ala Gln His Ile Ser Ile Thr Pro Tyr Leu Ser Leu Ser Tyr Thr 
            1380                1385                1390        
Asp Ala Ala Ser Gly Lys Val Arg Thr Arg Val Asn Thr Ala Val Leu 
        1395                1400                1405            
Ala Gln Asp Phe Gly Lys Thr Arg Ser Ala Glu Trp Gly Val Asn Ala 
    1410                1415                1420                
Glu Ile Lys Gly Phe Thr Leu Ser Leu His Ala Ala Ala Ala Lys Gly 
1425                1430                1435                1440
Pro Gln Leu Glu Ala Gln His Ser Ala Gly Ile Lys Leu Gly Tyr Arg 
                1445                1450                1455    
Trp 
    

<210> 4
<211> 4374
<212> DNA
<213> Neisseria meningitidis

<220> 
<221> source
<222> 1..4374
<223> /mol_type="unassigned DNA"
      /organism="Neisseria meningitidis"

<400> 4
atgaaaacaa ccgacaaacg gacaaccgaa acacaccgca aagccccgaa aaccggccgc       60

atccgcttct cgcctgctta cttagccata tgcctgtcgt tcggcattct tccccaagcc      120

tgggcgggac acacttattt cggcatcaac taccaatact atcgcgactt tgccgaaaat      180

aaaggcaagt ttgcagtcgg ggcgaaagat attgaggttt acaacaaaaa aggggagttg      240

gtcggcaaat caatgacaaa agccccgatg attgattttt ctgtggtgtc gcgtaacggc      300

gtggcggcat tggtgggcga tcaatatatt gtgagcgtgg cacataacgg cggctataac      360

aacgttgatt ttggtgcgga aggaagaaat cccgatcaac atcgttttac ttataaaatt      420

gtgaaacgga ataattataa agcagggact aaaggccatc cttatggcgg cgattatcat      480

atgccgcgtt tgcataaatt tgtcacagat gcagaacctg ttgaaatgac cagttatatg      540

gatgggcgga aatatatcga tcaaaataat taccctgacc gtgttcgtat tggggcaggc      600

aggcaatatt ggcgatctga tgaagatgag cccaataacc gcgaaagttc atatcatatt      660

gcaagtgcgt attcttggct cgttggtggc aatacctttg cacaaaatgg atcaggtggt      720

ggcacagtca acttaggtag tgaaaaaatt aaacatagcc catatggttt tttaccaaca      780

ggaggctcat ttggcgacag tggctcacca atgtttatct atgatgccca aaagcaaaag      840

tggttaatta atggggtatt gcaaacgggc aacccctata taggaaaaag caatggcttc      900

cagctggttc gtaaagattg gttctatgat gaaatctttg ctggagatac ccattcagta      960

ttctacgaac cacgtcaaaa tgggaaatac tcttttaacg acgataataa tggcacagga     1020

aaaatcaatg ccaaacatga acacaattct ctgcctaata gattaaaaac acgaaccgtt     1080

caattgttta atgtttcttt atccgagaca gcaagagaac ctgtttatca tgctgcaggt     1140

ggtgtcaaca gttatcgacc cagactgaat aatggagaaa atatttcctt tattgacgaa     1200

ggaaaaggcg aattgatact taccagcaac atcaatcaag gtgctggagg attatatttc     1260

caaggagatt ttacggtctc gcctgaaaat aacgaaactt ggcaaggcgc gggcgttcat     1320

atcagtgaag acagtaccgt tacttggaaa gtaaacggcg tggcaaacga ccgcctgtcc     1380

aaaatcggca aaggcacgct gcacgttcaa gccaaagggg aaaaccaagg ctcgatcagc     1440

gtgggcgacg gtacagtcat tttggatcag caggcagacg ataaaggcaa aaaacaagcc     1500

tttagtgaaa tcggcttggt cagcggcagg ggtacggtgc aactgaatgc cgataatcag     1560

ttcaaccccg acaaactcta tttcggcttt cgcggcggac gtttggattt aaacgggcat     1620

tcgctttcgt tccaccgtat tcaaaatacc gatgaagggg cgatgattgt caaccacaat     1680

caagacaaag aatccaccgt taccattaca ggcaataaag atattgctac aaccggcaat     1740

aacaacagct tggatagcaa aaaagaaatt gcctacaacg gttggtttgg cgagaaagat     1800

acgaccaaaa cgaacgggcg gctcaacctt gtttaccagc ccgccgcaga agaccgcacc     1860

ctgctgcttt ccggcggaac aaatttaaac ggcaacatca cgcaaacaaa cggcaaactg     1920

tttttcagcg gcagaccaac accgcacgcc tacaatcatt taaacgacca ttggtcgcaa     1980

aaagagggca ttcctcgcgg ggaaatcgtg tgggacaacg actggatcaa ccgcacattt     2040

aaagcggaaa acttccaaat taaaggcgga caggcggtgg tttcccgcaa tgttgccaaa     2100

gtgaaaggcg attggcattt gagcaatcac gcccaagcag tttttggtgt cgcaccgcat     2160

caaagccaca caatctgtac acgttcggac tggacgggtc tgacaaattg tgtcgaaaaa     2220

accattaccg acgataaagt gattgcttca ttgactaaga ccgacatcag cggcaatgtc     2280

gatcttgccg atcacgctca tttaaatctc acagggcttg ccacactcaa cggcaatctt     2340

agtgcaaatg gcgatacacg ttatacagtc agccacaacg ccacccaaaa cggcaacctt     2400

agcctcgtgg gcaatgccca agcaacattt aatcaagcca cattaaacgg caacacatcg     2460

gcttcgggca atgcttcatt taatctaagc gaccacgccg tacaaaacgg cagtctgacg     2520

ctttccggca acgctaaggc aaacgtaagc cattccgcac tcaacggtaa tgtctcccta     2580

gccgataagg cagtattcca ttttgaaagc agccgcttta ccggacaaat cagcggcggc     2640

aaggatacgg cattacactt aaaagacagc gaatggacgc tgccgtcagg cacggaatta     2700

ggcaatttaa accttgacaa cgccaccatt acactcaatt ccgcctatcg ccacgatgcg     2760

gcaggggcgc aaaccggcag tgcgacagat gcgccgcgcc gccgttcgcg ccgttcgcgc     2820

cgttccctat tatccgttac accgccaact tcggtagaat cccgtttcaa cacgctgacg     2880

gtaaacggca aattgaacgg tcagggaaca ttccgcttta tgtcggaact cttcggctac     2940

cgcagcgaca aattgaagct ggcggaaagt tccgaaggca cttacacctt ggcggtcaac     3000

aataccggca acgaacctgc aagcctcgaa caattgacgg tagtggaagg aaaagacaac     3060

aaaccgctgt ccgaaaacct taatttcacc ctgcaaaacg aacacgtcga tgccggcgcg     3120

tggcgttacc aactcatccg caaagacggc gagttccgcc tgcataatcc ggtcaaagaa     3180

caagagcttt ccgacaaact cggcaaggca gaagccaaaa aacaggcgga aaaagacaac     3240

gcgcaaagcc ttgacgcgct gattgcggcc gggcgcgatg ccgtcgaaaa gacagaaagc     3300

gttgccgaac cggcccggca ggcaggcggg gaaaatgtcg gcattatgca ggcggaggaa     3360

gagaaaaaac gggtgcaggc ggataaagac accgccttgg cgaaacagcg cgaagcggaa     3420

acccggccgg ctaccaccgc cttcccccgc gcccgccgcg cccgccggga tttgccgcaa     3480

ctgcaacccc aaccgcagcc ccaaccgcag cgcgacctga tcagccgtta tgccaatagc     3540

ggtttgagtg aattttccgc cacgctcaac agcgttttcg ccgtacagga cgaattagac     3600

cgcgtatttg ccgaagaccg ccgcaacgcc gtttggacaa gcggcatccg ggacaccaaa     3660

cactaccgtt cgcaagattt ccgcgcctac cgccaacaaa ccgacctgcg ccaaatcggt     3720

atgcagaaaa acctcggcag cgggcgcgtc ggcatcctgt tttcgcacaa ccggaccgaa     3780

aacaccttcg acgacggcat cggcaactcg gcacggcttg cccacggcgc cgttttcggg     3840

caatacggca tcgacaggtt ctacatcggc atcagcgcgg gcgcgggttt tagcagcggc     3900

agcctttcag acggcatcgg aggcaaaatc cgccgccgcg tgctgcatta cggcattcag     3960

gcacgatacc gcgccggttt cggcggattc ggcatcgaac cgcacatcgg cgcaacgcgc     4020

tatttcgtcc aaaaagcgga ttaccgctac gaaaacgtca atatcgccac ccccggcctt     4080

gcattcaacc gctaccgcgc gggcattaag gcagattatt cattcaaacc ggcgcaacac     4140

atttccatca cgccttattt gagcctgtcc tataccgatg ccgcttcggg caaagtccga     4200

acacgcgtca ataccgccgt attggctcag gatttcggca aaacccgcag tgcggaatgg     4260

ggcgtaaacg ccgaaatcaa aggtttcacg ctgtccctcc acgctgccgc cgccaaaggc     4320

ccgcaactgg aagcgcaaca cagcgcgggc atcaaattag gctaccgctg gtaa           4374


<210> 5
<211> 1431
<212> PRT
<213> Neisseria meningitidis


<400> 5
Met Arg Phe Thr His Thr Thr Pro Phe Cys Ser Val Leu Ser Thr Leu 
1               5                   10                  15      
Gly Leu Phe Ala Val Ser Pro Ala Tyr Ser Ser Ile Val Arg Asn Asp 
            20                  25                  30          
Val Asp Tyr Gln Tyr Phe Arg Asp Phe Ala Glu Asn Lys Gly Ala Phe 
        35                  40                  45              
Thr Val Gly Ala Ser Asn Ile Ser Ile Gln Asp Lys Gln Gly Lys Ile 
    50                  55                  60                  
Leu Gly Arg Val Leu Asn Gly Ile Pro Met Pro Asp Phe Arg Val Ser 
65                  70                  75                  80  
Asn Arg Gln Thr Ala Ile Ala Thr Leu Val His Pro Gln Tyr Val Asn 
                85                  90                  95      
Ser Val Lys His Asn Val Gly Tyr Gly Ser Ile Gln Phe Gly Asn Asp 
            100                 105                 110         
Thr Gln Asn Pro Glu Glu Gln Ala Tyr Thr Tyr Arg Leu Val Ser Arg 
        115                 120                 125             
Asn Pro His Pro Asp Tyr Asp Tyr His Leu Pro Arg Leu Asn Lys Leu 
    130                 135                 140                 
Val Thr Glu Ile Ser Pro Thr Ala Leu Ser Ser Val Pro Leu Leu Gly 
145                 150                 155                 160 
Asn Gly Gln Pro Lys Ala Asn Ala Tyr Leu Asp Thr Asp Arg Phe Pro 
                165                 170                 175     
Tyr Phe Val Arg Leu Gly Ser Gly Thr Gln Gln Val Arg Lys Ala Asp 
            180                 185                 190         
Gly Thr Arg Thr Arg Thr Ala Pro Ala Tyr Gln Tyr Leu Thr Gly Gly 
        195                 200                 205             
Thr Pro Leu Lys Val Leu Gly Phe Gln Asn His Gly Leu Leu Val Gly 
    210                 215                 220                 
Gly Ser Leu Thr Asp Gln Pro Leu Asn Thr Tyr Ala Ile Ala Gly Asp 
225                 230                 235                 240 
Ser Gly Ser Pro Leu Phe Ala Phe Asp Lys His Glu Asn Arg Trp Val 
                245                 250                 255     
Leu Ala Gly Val Leu Ser Thr Tyr Ala Gly Phe Asp Asn Phe Phe Asn 
            260                 265                 270         
Lys Tyr Ile Val Thr Gln Pro Glu Phe Ile Arg Ser Thr Ile Arg Gln 
        275                 280                 285             
Tyr Glu Thr Arg Leu Asp Val Gly Leu Thr Thr Asn Glu Leu Ile Trp 
    290                 295                 300                 
Arg Asp Asn Gly Asn Gly Asn Ser Thr Leu Gln Gly Leu Asn Glu Arg 
305                 310                 315                 320 
Ile Thr Leu Pro Ile Ala Asn Pro Ser Leu Ala Pro Gln Asn Asp Ser 
                325                 330                 335     
Arg His Met Pro Ser Glu Asp Ala Gly Lys Thr Leu Ile Leu Ser Ser 
            340                 345                 350         
Arg Phe Asp Asn Lys Thr Leu Met Leu Ala Asp Asn Ile Asn Gln Gly 
        355                 360                 365             
Ala Gly Ala Leu Gln Phe Asp Ser Asn Phe Thr Val Val Gly Lys Asn 
    370                 375                 380                 
His Thr Trp Gln Gly Ala Gly Val Ile Val Ala Asp Gly Lys Arg Val 
385                 390                 395                 400 
Phe Trp Gln Val Ser Asn Pro Lys Gly Asp Arg Leu Ser Lys Leu Gly 
                405                 410                 415     
Ala Gly Thr Leu Ile Ala Asn Gly Gln Gly Ile Asn Gln Gly Asp Ile 
            420                 425                 430         
Ser Ile Gly Glu Gly Thr Val Val Leu Ala Gln Lys Ala Ala Ser Asp 
        435                 440                 445             
Gly Ser Lys Gln Ala Phe Asn Gln Val Gly Ile Thr Ser Gly Arg Gly 
    450                 455                 460                 
Thr Ala Val Leu Ala Asp Ser Gln Gln Ile Lys Pro Glu Asn Leu Tyr 
465                 470                 475                 480 
Phe Gly Phe Arg Gly Gly Arg Leu Asp Leu Asn Gly Asn Asn Leu Ala 
                485                 490                 495     
Phe Thr His Ile Arg His Ala Asp Gly Gly Ala Gln Ile Val Asn His 
            500                 505                 510         
Asn Pro Asp Gln Ala Ala Thr Leu Thr Leu Thr Gly Asn Pro Val Leu 
        515                 520                 525             
Ser Pro Glu His Val Glu Trp Val Gln Trp Gly Asn Arg Pro Gln Gly 
    530                 535                 540                 
Asn Ala Ala Val Tyr Glu Tyr Ile Asn Pro His Arg Asn Arg Arg Thr 
545                 550                 555                 560 
Asp Tyr Phe Ile Leu Lys Pro Gly Gly Asn Pro Arg Glu Phe Phe Pro 
                565                 570                 575     
Leu Asn Met Lys Asn Ser Thr Ser Trp Gln Phe Ile Gly Asn Asn Arg 
            580                 585                 590         
Gln Gln Ala Ala Glu Gln Val Ala Gln Ala Glu Asn Ala Arg Pro Asp 
        595                 600                 605             
Leu Ile Thr Phe Gly Gly Tyr Leu Gly Glu Asn Ala Gln Thr Gly Lys 
    610                 615                 620                 
Ala Ala Pro Ser Tyr Ser Lys Thr Asn Glu Ala Ala Ile Glu Lys Thr 
625                 630                 635                 640 
Arg His Ile Ala Asn Ala Ala Val Tyr Gly Arg Pro Glu Tyr Arg Tyr 
                645                 650                 655     
Asn Gly Ala Leu Asn Leu His Tyr Arg Pro Lys Arg Thr Asp Ser Thr 
            660                 665                 670         
Leu Leu Leu Asn Gly Gly Met Asn Leu Asn Gly Glu Val Leu Ile Glu 
        675                 680                 685             
Gly Gly Asn Met Ile Val Ser Gly Arg Pro Val Pro His Ala Tyr Asp 
    690                 695                 700                 
His Gln Ala Lys Arg Glu Pro Val Leu Glu Asn Glu Trp Thr Asp Gly 
705                 710                 715                 720 
Ser Phe Lys Ala Ala Arg Phe Thr Leu Arg Asn His Ala Arg Leu Thr 
                725                 730                 735     
Ala Gly Arg Asn Thr Ala His Leu Asp Gly Asp Ile Thr Ala Tyr Asp 
            740                 745                 750         
Leu Ser Gly Ile Asp Leu Gly Phe Thr Gln Gly Lys Thr Pro Glu Cys 
        755                 760                 765             
Tyr Arg Ser Tyr His Ser Gly Ser Thr His Cys Thr Pro Asn Ala Val 
    770                 775                 780                 
Leu Lys Ala Glu Asn Tyr Arg Ala Leu Pro Ala Thr Gln Val Arg Gly 
785                 790                 795                 800 
Asp Ile Thr Leu Asn Asp Arg Ser Glu Leu Arg Leu Gly Lys Ala His 
                805                 810                 815     
Leu Tyr Gly Ser Ile Arg Ala Gly Lys Asp Thr Ala Val Arg Met Glu 
            820                 825                 830         
Ala Asp Ser Asn Trp Thr Leu Ser Gln Ser Ser His Thr Gly Ala Leu 
        835                 840                 845             
Thr Leu Asp Gly Ala Gln Ile Thr Leu Asn Pro Asp Phe Ala Asn Asn 
    850                 855                 860                 
Thr His Asn Asn Arg Phe Asn Thr Leu Thr Val Asn Gly Thr Leu Asp 
865                 870                 875                 880 
Gly Phe Gly Thr Phe Arg Phe Leu Thr Gly Ile Val Arg Lys Gln Asn 
                885                 890                 895     
Ala Pro Pro Leu Lys Leu Glu Gly Asp Ser Arg Gly Ala Phe Gln Ile 
            900                 905                 910         
His Val Lys Asn Thr Gly Gln Glu Pro Gln Thr Thr Glu Ser Leu Ala 
        915                 920                 925             
Leu Val Ser Leu Asn Pro Lys His Ser His Gln Ala Arg Phe Thr Leu 
    930                 935                 940                 
Gln Asn Gly Tyr Ala Asp Leu Gly Ala Tyr Arg Tyr Ile Leu Arg Lys 
945                 950                 955                 960 
Asn Asn Asn Gly Tyr Ser Leu Tyr Asn Pro Leu Lys Glu Ala Glu Leu 
                965                 970                 975     
Gln Ile Glu Ala Thr Arg Ala Glu His Glu Arg Asn Gln Gln Ala Tyr 
            980                 985                 990         
Asn Gln Leu Gln Ala Thr Asp Ile Ser Arg Gln Val Gln His Asp Ser 
        995                 1000                1005            
Asp Ala Thr Arg Gln Ala Leu Gln Ala Trp Gln Asn Ser Gln Thr Glu 
    1010                1015                1020                
Leu Ala Arg Ile Asp Ser Gln Val Gln Tyr Leu Ser Ala Gln Leu Lys 
1025                1030                1035                1040
Gln Thr Asp Pro Leu Thr Gly Ile Leu Thr Arg Ala Gln Asn Leu Cys 
                1045                1050                1055    
Ala Ala Gln Gly Tyr Ser Ala Asp Ile Cys Arg Gln Val Ala Lys Ala 
            1060                1065                1070        
Ala Asp Thr Asn Asp Leu Thr Leu Phe Glu Thr Glu Leu Asp Thr Tyr 
        1075                1080                1085            
Ile Glu Arg Val Glu Met Ala Glu Ser Glu Leu Asp Lys Ala Arg Gln 
    1090                1095                1100                
Gly Gly Asp Ala Gln Ala Val Glu Thr Ala Arg His Ala Tyr Leu Asn 
1105                1110                1115                1120
Ala Leu Asn Arg Leu Ser Arg Gln Ile His Ser Leu Lys Thr Gly Val 
                1125                1130                1135    
Ala Gly Ile Arg Met Pro Asn Leu Ala Glu Leu Ile Ser Arg Ser Ala 
            1140                1145                1150        
Asn Thr Ala Val Ser Glu Gln Ala Ala Tyr Asn Thr Gly Arg Gln Gln 
        1155                1160                1165            
Ala Gly Arg Arg Ile Asp Arg His Leu Thr Asp Pro Gln Gln Gln Asn 
    1170                1175                1180                
Ile Trp Leu Glu Thr Gly Thr Gln Gln Thr Asp Tyr His Ser Gly Thr 
1185                1190                1195                1200
His Arg Pro Tyr Gln Gln Thr Thr Asn Tyr Ala His Ile Gly Ile Gln 
                1205                1210                1215    
Thr Gly Ile Thr Asp Arg Leu Ser Val Gly Thr Ile Leu Thr Asp Glu 
            1220                1225                1230        
Arg Thr Asn Asn Arg Phe Asp Glu Gly Val Ser Ala Arg Asn Arg Ser 
        1235                1240                1245            
Asn Gly Ala His Leu Phe Val Lys Gly Glu Asn Gly Ala Leu Phe Ala 
    1250                1255                1260                
Ala Ala Asp Leu Gly Tyr Ser Asn Ser Arg Thr Arg Phe Thr Asp Tyr 
1265                1270                1275                1280
Asp Gly Ala Ala Val Arg Arg His Ala Trp Asp Ala Gly Ile Asn Thr 
                1285                1290                1295    
Gly Ile Lys Ile Asp Thr Gly Ile Asn Leu Arg Pro Tyr Ala Gly Ile 
            1300                1305                1310        
Arg Ile Asn Arg Ser Asn Gly Asn Arg Tyr Val Leu Asp Gly Ala Glu 
        1315                1320                1325            
Ile Asn Ser Pro Ala Gln Ile Gln Thr Thr Trp His Ala Gly Ile Arg 
    1330                1335                1340                
Leu Asp Lys Thr Val Glu Leu Gly Gln Ala Lys Leu Thr Pro Ala Phe 
1345                1350                1355                1360
Ser Ser Asp Tyr Tyr His Thr Arg Gln Asn Ser Gly Ser Ala Leu Ser 
                1365                1370                1375    
Val Asn Asp Arg Thr Leu Leu Gln Gln Ala Ala His Gly Thr Leu His 
            1380                1385                1390        
Thr Leu Gln Ile Asp Ala Gly Tyr Lys Gly Trp Asn Ala Lys Leu His 
        1395                1400                1405            
Ala Ala Tyr Gly Lys Asp Ser Asn Thr Ala Arg His Lys Gln Ala Gly 
    1410                1415                1420                
Ile Lys Ile Gly Tyr Asn Trp 
1425                1430    

<210> 6
<211> 4296
<212> DNA
<213> Neisseria meningitidis

<220> 
<221> source
<222> 1..4296
<223> /mol_type="unassigned DNA"
      /organism="Neisseria meningitidis"

<400> 6
atgcgcttca cacacaccac cccattttgt tccgtattgt ccaccctcgg tctttttgcc       60

gtttcccctg cttactcatc cattgtccgc aacgatgtcg attaccaata ttttcgcgac      120

tttgccgaaa ataaaggcgc gttcaccgta ggtgcaagca atatttccat ccaagacaag      180

caaggcaaaa tattaggcag ggttctcaac ggcatcccca tgcccgactt ccgcgtcagc      240

aaccgccaaa ccgccatcgc caccctggtt cacccccaat acgtcaacag tgtcaaacac      300

aacgtcggct acggttccat acaattcggc aacgacaccc aaaatccaga agaacaagcc      360

tatacctacc gcctcgtatc acgcaacccg cacccggact acgactacca ccttccccgc      420

ctcaacaaac tggttaccga aatctcacct accgcactca gcagcgtacc cttgcttgga      480

aacggccagc caaaggccaa tgcctacctc gataccgacc gcttccccta ctttgtacga      540

ctcggctcag gcacgcaaca agtccgcaaa gcagacggca cgcgtacacg aaccgccccg      600

gcataccaat acctgaccgg cggcacgccg ctgaaagtat tggggttcca aaaccacggc      660

ttactcgtcg gcggcagcct gaccgaccaa ccccttaaca cctacgcaat cgccggagac      720

agcggttccc ccctgtttgc cttcgacaag catgaaaacc gctgggtgct tgcgggcgta      780

ctcagcacct acgccggctt cgataatttc ttcaacaaat acatcgtcac gcaacccgaa      840

ttcatccgtt ccaccatccg ccaatacgaa acccggctgg atgtcgggct gaccaccaac      900

gaactcatat ggcgcgacaa cggtaatggc aacagcaccc tgcaagggct caacgaacgc      960

atcaccctgc ccattgcaaa cccttcgctt gccccacaaa acgacagcag gcacatgccg     1020

tctgaagatg ccggcaaaac gctcatccta tccagcaggt tcgacaacaa aacactgatg     1080

ctggcagaca atatcaacca aggcgcaggc gcattgcagt tcgacagcaa cttcaccgtc     1140

gtcggtaaaa accacacatg gcaaggtgca ggcgttatcg tagccgacgg caaacgcgtc     1200

ttctggcaag tcagcaaccc caaaggcgac cggctctcca aactgggcgc aggcacgctt     1260

atcgccaacg gacaaggcat caaccagggc gacatcagca tcggggaagg cactgtcgta     1320

ctcgcccaaa aagctgcttc agacggcagc aaacaagcat tcaaccaagt cggcatcacc     1380

agcggcaggg gcacggccgt cctcgccgac agccagcaaa tcaaacccga aaacctctat     1440

ttcggcttca ggggcggacg gctcgacctc aacggcaaca accttgcctt tacccatatc     1500

cgccatgcgg acggcggcgc gcaaatcgtc aatcacaacc ctgaccaagc cgcgacactg     1560

acgctgaccg gcaaccccgt cctcagtccc gagcatgtcg agtgggtgca atggggcaac     1620

cgtccgcaag gcaacgcggc ggtttacgaa tacatcaacc cgcaccgcaa ccgtcggacc     1680

gactacttca tactcaaacc cggcggcaac ccgcgcgaat ttttcccgtt aaatatgaaa     1740

aactcaacaa gctggcaatt tatcggcaac aacaggcaac aggccgccga acaagtcgcc     1800

caagccgaaa atgcccgccc cgacctgatt accttcggcg gatacttggg tgaaaacgcg     1860

caaacgggca aagccgcgcc gagttacagc aaaaccaatg aagcagccat agaaaaaacc     1920

cgccatatcg caaatgccgc cgtatacggc cggcccgaat accgttacaa cggcgcactc     1980

aacctgcact atcgtcccaa acgcaccgac agcacgctgt tgctcaacgg cggcatgaac     2040

cttaacgggg aagtcttgat tgagggcggc aatatgattg tgtcaggcag gcccgtaccc     2100

catgcctacg accaccaggc caaacgcgaa cccgttcttg aaaacgaatg gaccgacggc     2160

agcttcaagg ctgcacggtt caccctgcga aaccatgccc gactgacggc agggcgcaat     2220

accgcgcatc tggacggcga cataaccgca tacgatctgt ccggcatcga cctcggcttt     2280

acccaaggca aaacaccgga atgctaccgc tcctaccata gcggcagcac ccactgcaca     2340

cccaacgccg ttttaaaagc cgaaaactat cgtgcactac ctgcaacgca agtacgcggc     2400

gacattaccc ttaacgaccg ttcagagctc cgcctgggca aagcacacct gtacggcagc     2460

atccgtgccg gcaaagacac cgcagtccgc atggaagcag acagcaactg gacactttcc     2520

cagtccagcc acaccggcgc actgacgctt gacggcgcac aaattaccct gaaccccgat     2580

ttcgccaata atacacacaa caaccgcttc aacacactga ccgtcaacgg cacacttgac     2640

gggttcggca cattccgatt cctgaccggc atcgtccgaa aacaaaatgc cccccccctc     2700

aaactggaag gggacagccg cggcgcattc caaatccacg tcaaaaacac cggacaagaa     2760

cctcaaacaa ccgaatcgct tgcacttgtg agcctcaatc cgaaacacag ccaccaagcc     2820

cgattcaccc tccaaaacgg ctatgccgat ttgggtgcct accgctacat cctccgcaaa     2880

aacaacaacg gatacagcct gtacaacccg ctcaaagagg ccgaacttca aattgaagcc     2940

acgcgtgcgg aacatgagcg caaccaacag gcatacaacc aattacaggc aaccgacatc     3000

agcagacagg ttcaacatga ctctgacgcg accaggcagg cactacaggc ctggcagaac     3060

agtcaaaccg aacttgcccg catcgacagc caagtccaat atctgtccgc ccaattgaaa     3120

cagacagacc cgctgaccgg cattctgacg cgtgcccaaa acctgtgtgc cgcacaagga     3180

tacagtgccg atatctgccg tcaggttgcc aaagccgccg acacgaacga cctgacactc     3240

ttcgaaaccg aactggatac gtatatagaa cgtgtagaaa tggccgaatc cgaacttgac     3300

aaagcacggc aaggcggcga tgcgcaagcc gtcgaaacag cccggcacgc ctacctgaac     3360

gcactcaacc gtctgtcccg acaaatccac agtttgaaaa ccggcgttgc cggcatccgt     3420

atgccgaacc tggccgaact gatcagccgg tcggccaaca ccgccgtttc cgaacaggcc     3480

gcctacaata ccggccggca acaggcggga cgccgcatcg accgccacct taccgatccg     3540

cagcagcaaa acatctggct ggaaaccggt acgcaacaaa ccgactacca tagcggcaca     3600

caccgtccct accaacaaac taccaactat gcacatatcg gcatccaaac cggcatcacc     3660

gaccgtctca gtgtcggtac gattttaacc gatgagcgca caaacaaccg ttttgatgaa     3720

ggcgtatccg cccgaaaccg cagcaacggc gcacatctgt tcgtcaaagg ggaaaacggc     3780

gcactctttg ccgcggcaga tttaggctac agcaacagcc gtacccgatt taccgattat     3840

gacggggctg ccgtccgccg ccacgcatgg gatgcaggca tcaacaccgg catcaaaatc     3900

gataccggca tcaacctcag accctatgcc ggcatccgta taaaccgcag caacggcaac     3960

cggtacgtac tcgacggcgc agagataaac agcccggcgc aaatccaaac cacatggcat     4020

gccggcatcc gtctcgataa aaccgtcgaa ctgggtcaag ccaagctgac ccccgccttc     4080

agcagcgatt actaccatac ccgccaaaac agcggttccg ccctcagcgt caacgaccgt     4140

accttactgc agcaagccgc ccacggcaca ctgcataccc tgcaaatcga cgccggatac     4200

aaaggctgga acgccaaact tcatgccgct tacggcaaag acagcaacac cgcccgccac     4260

aaacaggcag gaatcaaaat aggctacaac tggtaa                               4296


