                               SEQUENCE LISTING

<110> DESSAIN, SCOTT KENDALL
      HEIMBACH, BARON CHRISTOPHER
 
<120> PDK1 BINDING MOLECULES AND USES THEREOF

<130> 125201-00320

<140>
<141>

<150> 62/088,530
<151> 2014-12-05

<160> 21    

<170> PatentIn version 3.5

<210> 1
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
ggatttgggc tgcgctgggt ttttcttgtg gctattttaa aaggtgtcca gtgtgaggtg       60

cagctgttgg agtcaggggg aggcttggta cagccggggg ggtccctgag actctcctgt      120

gcagcctctg ggttcacctt tagtaacttt ggcatgacct gggtccgcca ggctccgggg      180

aaggggctgg agtgggtctc aggtgtaagt attaggggca ttgccacata ctacgcagac      240

tccgtgaagg gccggttcac catctccagg gacgattcca ggaacacgtt gtatctacaa      300

atgaacagcc tgagagccga ggacacggcc ctttattact gtgcgaccgg tgttagactc      360

cttgggcgtg agtggggcca gggaaccctg gtcaccgtct cctcggcctc caccaagggc      420

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      480

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      540

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      600

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      660

aatcacaagc ccagcaacac caaggtggac aagagagttg agcccaaatc ttgtgacaaa      720

actcacacat gcccaccgtg cccagcacct gaactcctg                             759


<210> 2
<211> 253
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Gly Phe Gly Leu Arg Trp Val Phe Leu Val Ala Ile Leu Lys Gly Val 
1               5                   10                  15      


Gln Cys Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
        35                  40                  45              


Asn Phe Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Val Ser Gly Val Ser Ile Arg Gly Ile Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Arg Asn Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr 
            100                 105                 110         


Tyr Cys Ala Thr Gly Val Arg Leu Leu Gly Arg Glu Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
    130                 135                 140                 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
145                 150                 155                 160 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
                165                 170                 175     


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
            180                 185                 190         


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
        195                 200                 205             


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
    210                 215                 220                 


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
225                 230                 235                 240 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250             


<210> 3
<211> 405
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
ggatttgggc tgcgctgggt ttttcttgtg gctattttaa aaggtgtcca gtgtgaggtg       60

cagctgttgg agtcaggggg aggcttggta cagccggggg ggtccctgag actctcctgt      120

gcagcctctg ggttcacctt tagtaacttt ggcatgacct gggtccgcca ggctccgggg      180

aaggggctgg agtgggtctc aggtgtaagt attaggggca ttgccacata ctacgcagac      240

tccgtgaagg gccggttcac catctccagg gacgattcca ggaacacgtt gtatctacaa      300

atgaacagcc tgagagccga ggacacggcc ctttattact gtgcgaccgg tgttagactc      360

cttgggcgtg agtggggcca gggaaccctg gtcaccgtct cctcg                      405


<210> 4
<211> 135
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Gly Phe Gly Leu Arg Trp Val Phe Leu Val Ala Ile Leu Lys Gly Val 
1               5                   10                  15      


Gln Cys Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
        35                  40                  45              


Asn Phe Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Val Ser Gly Val Ser Ile Arg Gly Ile Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Arg Asn Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr 
            100                 105                 110         


Tyr Cys Ala Thr Gly Val Arg Leu Leu Gly Arg Glu Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ser 
    130                 135 


<210> 5
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Gly Phe Thr Phe Ser Asn Phe Gly 
1               5               


<210> 6
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Val Ser Ile Arg Gly Ile Ala Thr 
1               5               


<210> 7
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Cys Ala Thr Gly Val Arg Leu Leu Gly Arg Glu Trp 
1               5                   10          


<210> 8
<211> 720
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
atgaggctcc ctgctcagct cctggggctg ctaatgctct gggtcccagg ttccagtggg       60

gatgttgtga tgactcagtc tccactctcc ctgcccgtcc cccttggaca gccggcctcc      120

atctcctgca ggtctagtca aagcctcgtc gacaatgatg gaaacacgta cttgaattgg      180

tttcagcaga ggccaggcca atctccaagg cgcctaattt ataaggtttc tatgcgggac      240

tctggggtcc cagacagatt caccggcagt gggtcaggca ctgatttcac actgaggatt      300

agcagggtgg aggctgacga tgttggagtt tattactgca tgcaaggtac acactggcct      360

ctcactttcg gccctgggac caaagtggag atcaaacgaa ctgtggctgc accatctgtc      420

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      480

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      540

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      600

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      660

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag      720


<210> 9
<211> 219
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Pro Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Asp Asn 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Met Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Asp Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Leu Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210> 10
<211> 399
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
atgaggctcc ctgctcagct cctggggctg ctaatgctct gggtcccagg ttccagtggg       60

gatgttgtga tgactcagtc tccactctcc ctgcccgtcc cccttggaca gccggcctcc      120

atctcctgca ggtctagtca aagcctcgtc gacaatgatg gaaacacgta cttgaattgg      180

tttcagcaga ggccaggcca atctccaagg cgcctaattt ataaggtttc tatgcgggac      240

tctggggtcc cagacagatt caccggcagt gggtcaggca ctgatttcac actgaggatt      300

agcagggtgg aggctgacga tgttggagtt tattactgca tgcaaggtac acactggcct      360

ctcactttcg gccctgggac caaagtggag atcaaacga                             399


<210> 11
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Pro Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Asp Asn 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Met Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Asp Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Leu Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210> 12
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Gln Ser Leu Val Asp Asn Asp Gly Asn Thr Tyr 
1               5                   10      


<210> 13
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Lys Val Ser 
1           


<210> 14
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Cys Met Gln Gly Thr His Trp Pro Leu Thr Phe 
1               5                   10      


<210> 15
<211> 262
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Phe Gly Leu Arg Trp Val Phe Leu Val Ala Ile Leu Lys Gly Val Gln 
1               5                   10                  15      


Cys Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            20                  25                  30          


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn 
        35                  40                  45              


Phe Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    50                  55                  60                  


Val Ser Gly Val Ser Ile Arg Gly Ile Ala Thr Tyr Tyr Ala Asp Ser 
65                  70                  75                  80  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Arg Asn Thr Leu 
                85                  90                  95      


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr 
            100                 105                 110         


Cys Ala Thr Gly Val Arg Leu Leu Gly Arg Glu Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu 
145                 150                 155                 160 


Pro Val Pro Leu Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln 
                165                 170                 175     


Ser Leu Val Asp Asn Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln 
            180                 185                 190         


Arg Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr Lys Val Ser Met Arg 
        195                 200                 205             


Asp Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Asp Asp Val Gly Val Tyr 
225                 230                 235                 240 


Tyr Cys Met Gln Gly Thr His Trp Pro Leu Thr Phe Gly Pro Gly Thr 
                245                 250                 255     


Lys Val Glu Ile Lys Arg 
            260         


<210> 16
<211> 556
<212> PRT
<213> Homo sapiens

<400> 16
Met Ala Arg Thr Thr Ser Gln Leu Tyr Asp Ala Val Pro Ile Gln Ser 
1               5                   10                  15      


Ser Val Val Leu Cys Ser Cys Pro Ser Pro Ser Met Val Arg Thr Gln 
            20                  25                  30          


Thr Glu Ser Ser Thr Pro Pro Gly Ile Pro Gly Gly Ser Arg Gln Gly 
        35                  40                  45              


Pro Ala Met Asp Gly Thr Ala Ala Glu Pro Arg Pro Gly Ala Gly Ser 
    50                  55                  60                  


Leu Gln His Ala Gln Pro Pro Pro Gln Pro Arg Lys Lys Arg Pro Glu 
65                  70                  75                  80  


Asp Phe Lys Phe Gly Lys Ile Leu Gly Glu Gly Ser Phe Ser Thr Val 
                85                  90                  95      


Val Leu Ala Arg Glu Leu Ala Thr Ser Arg Glu Tyr Ala Ile Lys Ile 
            100                 105                 110         


Leu Glu Lys Arg His Ile Ile Lys Glu Asn Lys Val Pro Tyr Val Thr 
        115                 120                 125             


Arg Glu Arg Asp Val Met Ser Arg Leu Asp His Pro Phe Phe Val Lys 
    130                 135                 140                 


Leu Tyr Phe Thr Phe Gln Asp Asp Glu Lys Leu Tyr Phe Gly Leu Ser 
145                 150                 155                 160 


Tyr Ala Lys Asn Gly Glu Leu Leu Lys Tyr Ile Arg Lys Ile Gly Ser 
                165                 170                 175     


Phe Asp Glu Thr Cys Thr Arg Phe Tyr Thr Ala Glu Ile Val Ser Ala 
            180                 185                 190         


Leu Glu Tyr Leu His Gly Lys Gly Ile Ile His Arg Asp Leu Lys Pro 
        195                 200                 205             


Glu Asn Ile Leu Leu Asn Glu Asp Met His Ile Gln Ile Thr Asp Phe 
    210                 215                 220                 


Gly Thr Ala Lys Val Leu Ser Pro Glu Ser Lys Gln Ala Arg Ala Asn 
225                 230                 235                 240 


Ser Phe Val Gly Thr Ala Gln Tyr Val Ser Pro Glu Leu Leu Thr Glu 
                245                 250                 255     


Lys Ser Ala Cys Lys Ser Ser Asp Leu Trp Ala Leu Gly Cys Ile Ile 
            260                 265                 270         


Tyr Gln Leu Val Ala Gly Leu Pro Pro Phe Arg Ala Gly Asn Glu Tyr 
        275                 280                 285             


Leu Ile Phe Gln Lys Ile Ile Lys Leu Glu Tyr Asp Phe Pro Glu Lys 
    290                 295                 300                 


Phe Phe Pro Lys Ala Arg Asp Leu Val Glu Lys Leu Leu Val Leu Asp 
305                 310                 315                 320 


Ala Thr Lys Arg Leu Gly Cys Glu Glu Met Glu Gly Tyr Gly Pro Leu 
                325                 330                 335     


Lys Ala His Pro Phe Phe Glu Ser Val Thr Trp Glu Asn Leu His Gln 
            340                 345                 350         


Gln Thr Pro Pro Lys Leu Thr Ala Tyr Leu Pro Ala Met Ser Glu Asp 
        355                 360                 365             


Asp Glu Asp Cys Tyr Gly Asn Tyr Asp Asn Leu Leu Ser Gln Phe Gly 
    370                 375                 380                 


Cys Met Gln Val Ser Ser Ser Ser Ser Ser His Ser Leu Ser Ala Ser 
385                 390                 395                 400 


Asp Thr Gly Leu Pro Gln Arg Ser Gly Ser Asn Ile Glu Gln Tyr Ile 
                405                 410                 415     


His Asp Leu Asp Ser Asn Ser Phe Glu Leu Asp Leu Gln Phe Ser Glu 
            420                 425                 430         


Asp Glu Lys Arg Leu Leu Leu Glu Lys Gln Ala Gly Gly Asn Pro Trp 
        435                 440                 445             


His Gln Phe Val Glu Asn Asn Leu Ile Leu Lys Met Gly Pro Val Asp 
    450                 455                 460                 


Lys Arg Lys Gly Leu Phe Ala Arg Arg Arg Gln Leu Leu Leu Thr Glu 
465                 470                 475                 480 


Gly Pro His Leu Tyr Tyr Val Asp Pro Val Asn Lys Val Leu Lys Gly 
                485                 490                 495     


Glu Ile Pro Trp Ser Gln Glu Leu Arg Pro Glu Ala Lys Asn Phe Lys 
            500                 505                 510         


Thr Phe Phe Val His Thr Pro Asn Arg Thr Tyr Tyr Leu Met Asp Pro 
        515                 520                 525             


Ser Gly Asn Ala His Lys Trp Cys Arg Lys Ile Gln Glu Val Trp Arg 
    530                 535                 540                 


Gln Arg Tyr Gln Ser His Pro Asp Ala Ala Val Gln 
545                 550                 555     


<210> 17
<211> 506
<212> PRT
<213> Homo sapiens

<400> 17
Met Asp Gly Thr Ala Ala Glu Pro Arg Pro Gly Ala Gly Ser Leu Gln 
1               5                   10                  15      


His Ala Gln Pro Pro Pro Gln Pro Arg Lys Lys Arg Pro Glu Asp Phe 
            20                  25                  30          


Lys Phe Gly Lys Ile Leu Gly Glu Gly Ser Phe Ser Thr Val Val Leu 
        35                  40                  45              


Ala Arg Glu Leu Ala Thr Ser Arg Glu Tyr Ala Ile Lys Ile Leu Glu 
    50                  55                  60                  


Lys Arg His Ile Ile Lys Glu Asn Lys Val Pro Tyr Val Thr Arg Glu 
65                  70                  75                  80  


Arg Asp Val Met Ser Arg Leu Asp His Pro Phe Phe Val Lys Leu Tyr 
                85                  90                  95      


Phe Thr Phe Gln Asp Asp Glu Lys Leu Tyr Phe Gly Leu Ser Tyr Ala 
            100                 105                 110         


Lys Asn Gly Glu Leu Leu Lys Tyr Ile Arg Lys Ile Gly Ser Phe Asp 
        115                 120                 125             


Glu Thr Cys Thr Arg Phe Tyr Thr Ala Glu Ile Val Ser Ala Leu Glu 
    130                 135                 140                 


Tyr Leu His Gly Lys Gly Ile Ile His Arg Asp Leu Lys Pro Glu Asn 
145                 150                 155                 160 


Ile Leu Leu Asn Glu Asp Met His Ile Gln Ile Thr Asp Phe Gly Thr 
                165                 170                 175     


Ala Lys Val Leu Ser Pro Glu Ser Lys Gln Ala Arg Ala Asn Ser Phe 
            180                 185                 190         


Val Gly Thr Ala Gln Tyr Val Ser Pro Glu Leu Leu Thr Glu Lys Ser 
        195                 200                 205             


Ala Cys Lys Ser Ser Asp Leu Trp Ala Leu Gly Cys Ile Ile Tyr Gln 
    210                 215                 220                 


Leu Val Ala Gly Leu Pro Pro Phe Arg Ala Gly Asn Glu Tyr Leu Ile 
225                 230                 235                 240 


Phe Gln Lys Ile Ile Lys Leu Glu Tyr Asp Phe Pro Glu Lys Phe Phe 
                245                 250                 255     


Pro Lys Ala Arg Asp Leu Val Glu Lys Leu Leu Val Leu Asp Ala Thr 
            260                 265                 270         


Lys Arg Leu Gly Cys Glu Glu Met Glu Gly Tyr Gly Pro Leu Lys Ala 
        275                 280                 285             


His Pro Phe Phe Glu Ser Val Thr Trp Glu Asn Leu His Gln Gln Thr 
    290                 295                 300                 


Pro Pro Lys Leu Thr Ala Tyr Leu Pro Ala Met Ser Glu Asp Asp Glu 
305                 310                 315                 320 


Asp Cys Tyr Gly Asn Tyr Asp Asn Leu Leu Ser Gln Phe Gly Cys Met 
                325                 330                 335     


Gln Val Ser Ser Ser Ser Ser Ser His Ser Leu Ser Ala Ser Asp Thr 
            340                 345                 350         


Gly Leu Pro Gln Arg Ser Gly Ser Asn Ile Glu Gln Tyr Ile His Asp 
        355                 360                 365             


Leu Asp Ser Asn Ser Phe Glu Leu Asp Leu Gln Phe Ser Glu Asp Glu 
    370                 375                 380                 


Lys Arg Leu Leu Leu Glu Lys Gln Ala Gly Gly Asn Pro Trp His Gln 
385                 390                 395                 400 


Phe Val Glu Asn Asn Leu Ile Leu Lys Met Gly Pro Val Asp Lys Arg 
                405                 410                 415     


Lys Gly Leu Phe Ala Arg Arg Arg Gln Leu Leu Leu Thr Glu Gly Pro 
            420                 425                 430         


His Leu Tyr Tyr Val Asp Pro Val Asn Lys Val Leu Lys Gly Glu Ile 
        435                 440                 445             


Pro Trp Ser Gln Glu Leu Arg Pro Glu Ala Lys Asn Phe Lys Thr Phe 
    450                 455                 460                 


Phe Val His Thr Pro Asn Arg Thr Tyr Tyr Leu Met Asp Pro Ser Gly 
465                 470                 475                 480 


Asn Ala His Lys Trp Cys Arg Lys Ile Gln Glu Val Trp Arg Gln Arg 
                485                 490                 495     


Tyr Gln Ser His Pro Asp Ala Ala Val Gln 
            500                 505     


<210> 18
<211> 530
<212> PRT
<213> Homo sapiens

<400> 18
Met Ala Arg Thr Thr Ser Gln Leu Tyr Asp Ala Val Pro Ile Gln Ser 
1               5                   10                  15      


Ser Val Val Leu Cys Ser Cys Pro Ser Pro Ser Met Val Arg Thr Gln 
            20                  25                  30          


Thr Glu Ser Ser Thr Pro Pro Gly Ile Pro Gly Gly Ser Arg Gln Gly 
        35                  40                  45              


Pro Ala Met Asp Gly Thr Ala Ala Glu Pro Arg Pro Gly Ala Gly Ser 
    50                  55                  60                  


Leu Gln His Ala Gln Pro Pro Pro Gln Pro Arg Lys Lys Arg Pro Glu 
65                  70                  75                  80  


Asp Phe Lys Phe Gly Lys Ile Leu Gly Glu Gly Ser Phe Ser Thr Val 
                85                  90                  95      


Val Leu Ala Arg Glu Leu Ala Thr Ser Arg Glu Tyr Ala Ile Lys Ile 
            100                 105                 110         


Leu Glu Lys Arg His Ile Ile Lys Glu Asn Lys Val Pro Tyr Val Thr 
        115                 120                 125             


Arg Glu Arg Asp Val Met Ser Arg Leu Asp His Pro Phe Phe Val Lys 
    130                 135                 140                 


Leu Tyr Phe Thr Phe Gln Asp Asp Glu Lys Leu Tyr Phe Gly Leu Ser 
145                 150                 155                 160 


Tyr Ala Lys Asn Gly Glu Leu Leu Lys Tyr Ile Arg Lys Ile Gly Ser 
                165                 170                 175     


Phe Asp Glu Thr Cys Thr Arg Phe Tyr Thr Ala Glu Ile Val Ser Ala 
            180                 185                 190         


Leu Glu Tyr Leu His Gly Lys Gly Ile Ile His Arg Asp Leu Lys Pro 
        195                 200                 205             


Glu Asn Ile Leu Leu Asn Glu Asp Met His Ile Gln Ile Thr Asp Phe 
    210                 215                 220                 


Gly Thr Ala Lys Val Leu Ser Pro Glu Ser Lys Gln Ala Asp Leu Trp 
225                 230                 235                 240 


Ala Leu Gly Cys Ile Ile Tyr Gln Leu Val Ala Gly Leu Pro Pro Phe 
                245                 250                 255     


Arg Ala Gly Asn Glu Tyr Leu Ile Phe Gln Lys Ile Ile Lys Leu Glu 
            260                 265                 270         


Tyr Asp Phe Pro Glu Lys Phe Phe Pro Lys Ala Arg Asp Leu Val Glu 
        275                 280                 285             


Lys Leu Leu Val Leu Asp Ala Thr Lys Arg Leu Gly Cys Glu Glu Met 
    290                 295                 300                 


Glu Gly Tyr Gly Pro Leu Lys Ala His Pro Phe Phe Glu Ser Val Thr 
305                 310                 315                 320 


Trp Glu Asn Leu His Gln Gln Thr Pro Pro Lys Leu Thr Ala Tyr Leu 
                325                 330                 335     


Pro Ala Met Ser Glu Asp Asp Glu Asp Cys Tyr Gly Asn Tyr Asp Asn 
            340                 345                 350         


Leu Leu Ser Gln Phe Gly Cys Met Gln Val Ser Ser Ser Ser Ser Ser 
        355                 360                 365             


His Ser Leu Ser Ala Ser Asp Thr Gly Leu Pro Gln Arg Ser Gly Ser 
    370                 375                 380                 


Asn Ile Glu Gln Tyr Ile His Asp Leu Asp Ser Asn Ser Phe Glu Leu 
385                 390                 395                 400 


Asp Leu Gln Phe Ser Glu Asp Glu Lys Arg Leu Leu Leu Glu Lys Gln 
                405                 410                 415     


Ala Gly Gly Asn Pro Trp His Gln Phe Val Glu Asn Asn Leu Ile Leu 
            420                 425                 430         


Lys Met Gly Pro Val Asp Lys Arg Lys Gly Leu Phe Ala Arg Arg Arg 
        435                 440                 445             


Gln Leu Leu Leu Thr Glu Gly Pro His Leu Tyr Tyr Val Asp Pro Val 
    450                 455                 460                 


Asn Lys Val Leu Lys Gly Glu Ile Pro Trp Ser Gln Glu Leu Arg Pro 
465                 470                 475                 480 


Glu Ala Lys Asn Phe Lys Thr Phe Phe Val His Thr Pro Asn Arg Thr 
                485                 490                 495     


Tyr Tyr Leu Met Asp Pro Ser Gly Asn Ala His Lys Trp Cys Arg Lys 
            500                 505                 510         


Ile Gln Glu Val Trp Arg Gln Arg Tyr Gln Ser His Pro Asp Ala Ala 
        515                 520                 525             


Val Gln 
    530 


<210> 19
<211> 429
<212> PRT
<213> Homo sapiens

<400> 19
Met Ala Arg Thr Thr Ser Gln Leu Tyr Asp Ala Val Pro Ile Gln Ser 
1               5                   10                  15      


Ser Val Val Leu Cys Ser Cys Pro Ser Pro Ser Met Val Arg Thr Gln 
            20                  25                  30          


Thr Glu Ser Ser Thr Pro Pro Gly Ile Pro Gly Gly Ser Arg Gln Gly 
        35                  40                  45              


Pro Ala Met Asp Gly Thr Ala Ala Glu Pro Arg Pro Gly Ala Gly Ser 
    50                  55                  60                  


Leu Gln His Ala Gln Pro Pro Pro Gln Pro Arg Lys Lys Arg Pro Glu 
65                  70                  75                  80  


Asp Phe Lys Phe Gly Lys Ile Leu Gly Glu Gly Ser Phe Ser Thr Val 
                85                  90                  95      


Val Leu Ala Arg Glu Leu Ala Thr Ser Arg Glu Tyr Ala Thr Arg Ala 
            100                 105                 110         


Asn Ser Phe Val Gly Thr Ala Gln Tyr Val Ser Pro Glu Leu Leu Thr 
        115                 120                 125             


Glu Lys Ser Ala Cys Lys Ser Ser Asp Leu Trp Ala Leu Gly Cys Ile 
    130                 135                 140                 


Ile Tyr Gln Leu Val Ala Gly Leu Pro Pro Phe Arg Ala Gly Asn Glu 
145                 150                 155                 160 


Tyr Leu Ile Phe Gln Lys Ile Ile Lys Leu Glu Tyr Asp Phe Pro Glu 
                165                 170                 175     


Lys Phe Phe Pro Lys Ala Arg Asp Leu Val Glu Lys Leu Leu Val Leu 
            180                 185                 190         


Asp Ala Thr Lys Arg Leu Gly Cys Glu Glu Met Glu Gly Tyr Gly Pro 
        195                 200                 205             


Leu Lys Ala His Pro Phe Phe Glu Ser Val Thr Trp Glu Asn Leu His 
    210                 215                 220                 


Gln Gln Thr Pro Pro Lys Leu Thr Ala Tyr Leu Pro Ala Met Ser Glu 
225                 230                 235                 240 


Asp Asp Glu Asp Cys Tyr Gly Asn Tyr Asp Asn Leu Leu Ser Gln Phe 
                245                 250                 255     


Gly Cys Met Gln Val Ser Ser Ser Ser Ser Ser His Ser Leu Ser Ala 
            260                 265                 270         


Ser Asp Thr Gly Leu Pro Gln Arg Ser Gly Ser Asn Ile Glu Gln Tyr 
        275                 280                 285             


Ile His Asp Leu Asp Ser Asn Ser Phe Glu Leu Asp Leu Gln Phe Ser 
    290                 295                 300                 


Glu Asp Glu Lys Arg Leu Leu Leu Glu Lys Gln Ala Gly Gly Asn Pro 
305                 310                 315                 320 


Trp His Gln Phe Val Glu Asn Asn Leu Ile Leu Lys Met Gly Pro Val 
                325                 330                 335     


Asp Lys Arg Lys Gly Leu Phe Ala Arg Arg Arg Gln Leu Leu Leu Thr 
            340                 345                 350         


Glu Gly Pro His Leu Tyr Tyr Val Asp Pro Val Asn Lys Val Leu Lys 
        355                 360                 365             


Gly Glu Ile Pro Trp Ser Gln Glu Leu Arg Pro Glu Ala Lys Asn Phe 
    370                 375                 380                 


Lys Thr Phe Phe Val His Thr Pro Asn Arg Thr Tyr Tyr Leu Met Asp 
385                 390                 395                 400 


Pro Ser Gly Asn Ala His Lys Trp Cys Arg Lys Ile Gln Glu Val Trp 
                405                 410                 415     


Arg Gln Arg Tyr Gln Ser His Pro Asp Ala Ala Val Gln 
            420                 425                 


<210> 20
<211> 454
<212> PRT
<213> Homo sapiens

<400> 20
Met Ala Arg Thr Thr Ser Gln Leu Tyr Asp Ala Val Pro Ile Gln Ser 
1               5                   10                  15      


Ser Val Val Leu Cys Ser Cys Pro Ser Pro Ser Met Val Arg Thr Gln 
            20                  25                  30          


Thr Glu Ser Ser Thr Pro Pro Gly Ile Pro Gly Gly Ser Arg Gln Gly 
        35                  40                  45              


Pro Ala Met Asp Gly Thr Ala Ala Glu Pro Arg Pro Gly Ala Gly Ser 
    50                  55                  60                  


Leu Gln His Ala Gln Pro Pro Pro Gln Pro Arg Lys Lys Arg Pro Glu 
65                  70                  75                  80  


Asp Phe Lys Phe Gly Lys Ile Leu Gly Glu Gly Ser Phe Ser Thr Val 
                85                  90                  95      


Val Leu Ala Arg Glu Leu Ala Thr Ser Arg Glu Tyr Ala Ile Lys Ile 
            100                 105                 110         


Leu Glu Lys Arg His Ile Ile Lys Glu Asn Lys Val Pro Tyr Val Thr 
        115                 120                 125             


Arg Glu Arg Asp Val Met Ser Arg Leu Asp His Pro Phe Phe Val Lys 
    130                 135                 140                 


Leu Tyr Phe Thr Phe Gln Asp Asp Glu Lys Leu Tyr Phe Gly Leu Ser 
145                 150                 155                 160 


Tyr Ala Lys Asn Gly Glu Leu Leu Lys Tyr Ile Arg Lys Ile Gly Ser 
                165                 170                 175     


Phe Asp Glu Thr Cys Thr Arg Phe Tyr Thr Ala Glu Ile Val Ser Ala 
            180                 185                 190         


Leu Glu Tyr Leu His Gly Lys Gly Ile Ile His Arg Asp Leu Lys Pro 
        195                 200                 205             


Glu Asn Ile Leu Leu Asn Glu Asp Met His Ile Gln Ile Thr Asp Phe 
    210                 215                 220                 


Gly Thr Ala Lys Val Leu Ser Pro Glu Ser Lys Gln Ala Arg Ala Asn 
225                 230                 235                 240 


Ser Phe Val Gly Thr Ala Gln Tyr Val Ser Pro Glu Leu Leu Thr Glu 
                245                 250                 255     


Lys Ser Ala Cys Lys Ser Ser Asp Leu Trp Ala Leu Gly Cys Ile Ile 
            260                 265                 270         


Tyr Gln Leu Val Ala Gly Leu Pro Pro Phe Arg Ala Gly Asn Glu Tyr 
        275                 280                 285             


Leu Ile Phe Gln Lys Ile Ile Lys Leu Glu Tyr Asp Phe Pro Glu Lys 
    290                 295                 300                 


Phe Phe Pro Lys Ala Arg Asp Leu Val Glu Lys Leu Leu Val Leu Asp 
305                 310                 315                 320 


Ala Thr Lys Arg Leu Gly Cys Glu Glu Met Glu Gly Tyr Gly Pro Leu 
                325                 330                 335     


Lys Ala His Pro Phe Phe Glu Ser Val Thr Trp Glu Asn Leu His Gln 
            340                 345                 350         


Gln Thr Pro Pro Lys Leu Thr Ala Tyr Leu Pro Ala Met Ser Glu Asp 
        355                 360                 365             


Asp Glu Asp Cys Tyr Gly Asn Tyr Asp Asn Leu Leu Ser Gln Phe Gly 
    370                 375                 380                 


Cys Met Gln Val Ser Ser Ser Ser Ser Ser His Ser Leu Ser Ala Ser 
385                 390                 395                 400 


Asp Thr Gly Leu Pro Gln Arg Ser Gly Ser Asn Ile Glu Gln Tyr Ile 
                405                 410                 415     


His Asp Leu Asp Ser Asn Ser Phe Glu Leu Asp Leu Gln Phe Ser Glu 
            420                 425                 430         


Asp Glu Lys Arg Leu Leu Leu Glu Lys Gln Ala Gly Gly Asn Pro Cys 
        435                 440                 445             


Leu Thr Gly Arg Ile Ile 
    450                 


<210> 21
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


